YU48741B - Derivati i analozi 2-dezoksi-2,3-didehidro-n-acetil-neuraminske kiseline i postupak za njihovo dobijanje - Google Patents

Derivati i analozi 2-dezoksi-2,3-didehidro-n-acetil-neuraminske kiseline i postupak za njihovo dobijanje

Info

Publication number
YU48741B
YU48741B YU74591A YU74591A YU48741B YU 48741 B YU48741 B YU 48741B YU 74591 A YU74591 A YU 74591A YU 74591 A YU74591 A YU 74591A YU 48741 B YU48741 B YU 48741B
Authority
YU
Yugoslavia
Prior art keywords
hydrogen
didehydro
deoxy
analogues
derivatives
Prior art date
Application number
YU74591A
Other languages
English (en)
Other versions
YU74591A (sh
Inventor
Itzstein Von
Wen-Yang Wu
Tho Van Phan
Basil Danylec
Betty Jin
Original Assignee
Biota Scientific Management Pty Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biota Scientific Management Pty Ltd. filed Critical Biota Scientific Management Pty Ltd.
Priority to SI9110745A priority Critical patent/SI9110745B/sl
Priority to HRP-745/91A priority patent/HRP930455B1/xx
Publication of YU74591A publication Critical patent/YU74591A/sh
Publication of YU48741B publication Critical patent/YU48741B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Jedinjenje, naznačeno time, što ima formulu (1b) u kojoj R36 je (alk)x NR6bR7b, ili CN ili N3, gde alk je nesupstituisan ili supstituisan metilen, x je 0 ili 1 R6b je vodonik, C1-6alkil, aril, aralkil, amidin, NR7bR8b ili nezasićen ili zasićen prsten koji sadrži jedan ili više heteroatoma (kao što su azot, kiseonik ili sumpor), R7b je vodonik, C1-6alkil ili alil, ili NR6bR7b obrazuje opciono supstituisan 5-to ili 6-točlani prsten koji opciono sadrži jedan ili više dodatnih heteroatoma, R8b je vodonik ili C1-6alkil i R4b je NHCOR9b, gde je R9b vodonik, supstituisan ili nesupstituisan C1-4 alkil ili aril. - Prijava sadrži još 6 nezavisnih i 3 zavisna zahteva.
YU74591A 1990-04-24 1991-04-24 Derivati i analozi 2-dezoksi-2,3-didehidro-n-acetil-neuraminske kiseline i postupak za njihovo dobijanje YU48741B (sh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI9110745A SI9110745B (en) 1990-04-24 1991-04-24 Anti-viral compounds.
HRP-745/91A HRP930455B1 (en) 1990-04-24 1993-03-23 Antiviral compounds

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPJ980090 1990-04-24
AUPK289690 1990-10-19
AUPK453791 1991-02-11

Publications (2)

Publication Number Publication Date
YU74591A YU74591A (sh) 1994-06-24
YU48741B true YU48741B (sh) 1999-09-27

Family

ID=27157556

Family Applications (1)

Application Number Title Priority Date Filing Date
YU74591A YU48741B (sh) 1990-04-24 1991-04-24 Derivati i analozi 2-dezoksi-2,3-didehidro-n-acetil-neuraminske kiseline i postupak za njihovo dobijanje

Country Status (37)

Country Link
US (2) US5360817A (sh)
EP (2) EP0786458B1 (sh)
JP (1) JP2944750B2 (sh)
KR (1) KR0169496B1 (sh)
CN (3) CN1036849C (sh)
AP (1) AP249A (sh)
AT (2) ATE161253T1 (sh)
AU (2) AU7533891A (sh)
BG (1) BG62092B1 (sh)
CA (2) CA2291994C (sh)
CY (1) CY2186B1 (sh)
CZ (1) CZ288492B6 (sh)
DE (3) DE19975068I2 (sh)
DK (1) DK0526543T3 (sh)
ES (2) ES2113881T3 (sh)
FI (2) FI105478B (sh)
GR (1) GR3026225T3 (sh)
HK (2) HK1003834A1 (sh)
HU (2) HU219355B (sh)
IE (2) IE980526A1 (sh)
IL (1) IL97936A (sh)
LU (1) LU90468I2 (sh)
MY (1) MY107843A (sh)
NL (1) NL990030I2 (sh)
NO (3) NO302751B1 (sh)
NZ (1) NZ237936A (sh)
OA (1) OA09679A (sh)
PL (3) PL166918B1 (sh)
PT (1) PT97460B (sh)
RU (1) RU2119487C1 (sh)
SG (1) SG43170A1 (sh)
SI (1) SI9110745B (sh)
SK (1) SK282950B6 (sh)
UA (1) UA41252C2 (sh)
WO (1) WO1991016320A1 (sh)
YU (1) YU48741B (sh)
ZA (1) ZA913086B (sh)

Families Citing this family (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2081068C (en) * 1991-10-23 2005-11-29 Laurence Mark Von Itzstein Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of .alpha.-d-neuraminic acid
GB9126725D0 (en) * 1991-12-17 1992-02-12 Glaxo Group Ltd Process
GB9220327D0 (en) * 1992-09-25 1992-11-11 Glaxo Group Ltd Process
GB9220241D0 (en) * 1992-09-25 1992-11-11 Glaxo Group Ltd Process
GB9312531D0 (en) * 1993-06-17 1993-08-04 Glaxo Group Ltd Process
US5958973A (en) * 1993-09-03 1999-09-28 Gilead Sciences, Inc. Polyhydroxy benzoic acid derivatives and their use as neuraminidase inhibitors
GB9325841D0 (en) 1993-12-17 1994-02-23 Glaxo Group Ltd Chemical compounds
GB9400206D0 (en) * 1994-01-07 1994-03-02 Glaxo Group Ltd Chemical compound
AUPM354694A0 (en) * 1994-01-27 1994-02-17 Biota Scientific Management Pty Ltd Chemical compounds
US5453533A (en) * 1994-04-14 1995-09-26 The University Of Alabama At Birmingham Inhibitors of influenza virus neuraminidase and methods of making and using the same
US5985859A (en) * 1994-04-14 1999-11-16 The University Of Alabama Methods of inhibiting bacterial sialidase
WO1995032955A1 (fr) * 1994-05-27 1995-12-07 Daikin Industries, Ltd. Acide 7-fluoro-2, 3-didehydrosialique et intermediaire pour la synthese de cet acide
GB9410817D0 (en) * 1994-05-28 1994-07-20 Glaxo Group Ltd Medicaments
AUPM725794A0 (en) * 1994-08-03 1994-08-25 Biota Scientific Management Pty Ltd Chemical compounds
US5556963A (en) * 1994-08-05 1996-09-17 Oklahoma Medical Research Foundation Synthesis of 4-alkoxy-N-acetylneuraminic acid
GB9416365D0 (en) * 1994-08-12 1994-10-05 Glaxo Group Ltd Medicaments
US5512596A (en) * 1994-09-02 1996-04-30 Gilead Sciences, Inc. Aromatic compounds
US5475109A (en) * 1994-10-17 1995-12-12 Merck & Co., Inc. Dioxobutanoic acid derivatives as inhibitors of influenza endonuclease
US5866601A (en) * 1995-02-27 1999-02-02 Gilead Sciences, Inc. Carbocyclic compounds
AU4259500A (en) * 1995-02-27 2000-08-31 Gilead Sciences, Inc. Novel compounds and methods for synthesis and therapy
CN101143859A (zh) * 1995-02-27 2008-03-19 吉里德科学公司 新颖化合物,其合成方法及治疗用途
WO1996026933A1 (en) * 1995-02-27 1996-09-06 Gilead Sciences, Inc. Novel selective inhibitors of viral or bacterial neuraminidases
CA2546660C (en) * 1995-02-27 2009-08-11 Gilead Sciences Inc. Selective inhibitors of viral or bacterial neuraminidase
US5602277A (en) * 1995-03-30 1997-02-11 Biocryst Pharmaceuticals, Inc. Substituted benzene derivatives useful as neuraminidase inhibitors
US5714509A (en) * 1995-05-03 1998-02-03 The University Of Alabama Inhibitors of bacterial sialidase and methods of making and using the same
WO1996036628A1 (en) * 1995-05-19 1996-11-21 Biota Scientific Management Pty. Ltd. 6-carboxamido dihydropyran derivatives
GB9516276D0 (en) * 1995-08-08 1995-10-11 Biota Scient Management Chemical compounds
JPH0967270A (ja) * 1995-08-31 1997-03-11 Res Dev Corp Of Japan 水晶体混濁の予防および治療法、並びにそのための薬 剤
US5763483A (en) * 1995-12-29 1998-06-09 Gilead Sciences, Inc. Carbocyclic compounds
DE69721242T2 (de) * 1996-03-01 2004-01-29 Biota Scient Management Verfahren zum nachweis von influenza-virus und dazu verwendbare verbindungen
US6093816A (en) 1996-06-27 2000-07-25 Isis Pharmaceuticals, Inc. Cationic lipids
US6451766B1 (en) 1996-07-22 2002-09-17 Sankyo Company, Limited Neuraminic acid derivatives, their preparation and their medical use
PT823428E (pt) * 1996-07-22 2002-04-29 Sankyo Co Derivados do acido neuraminico sua preparacao e sua utilizacao em medicina
US6340702B1 (en) 1996-07-22 2002-01-22 Sankyo Company, Limited Neuraminic acid derivatives, their preparation and their medical use
PT934939E (pt) * 1996-08-13 2003-07-31 Sankyo Co Compostos de acido neuraminico
US6518438B2 (en) 1996-08-23 2003-02-11 Gilead Sciences, Inc. Preparation of cyclohexene carboxylate derivatives
US5859284A (en) * 1996-08-23 1999-01-12 Gilead Sciences, Inc. Preparation of carbocyclic compounds
WO1998011083A1 (fr) * 1996-09-10 1998-03-19 Daikin Industries, Ltd. Acides sialiques 2,7-dideoxy-7-fluoro- 2, 3-didehydro a quadruple substitution
US5719020A (en) * 1996-09-25 1998-02-17 Oklahoma Medical Research Foundation 4,7-dialkoxy N-acetylneuraminic acid derivatives and methods for detection of influenza type A and B viruses in clinical specimens
CN1238762A (zh) * 1996-10-21 1999-12-15 吉里德科学公司 哌啶化合物
US5994377A (en) 1996-10-21 1999-11-30 Gilead Sciences, Inc. Piperidine compounds
CA2271249C (en) 1996-11-14 2010-07-20 Biota Scientific Management Pty. Ltd. Macromolecular neuraminidase-binding compounds
US5886213A (en) * 1997-08-22 1999-03-23 Gilead Sciences, Inc. Preparation of carbocyclic compounds
JP3390965B2 (ja) 1997-09-12 2003-03-31 理化学研究所 糖結合スフィンゴシンを含有するポリマー化合物
US20040053999A1 (en) * 1997-09-17 2004-03-18 Bischofberger Norbert W. Novel compounds and methods for synthesis and therapy
WO1999014185A1 (en) * 1997-09-17 1999-03-25 Gilead Sciences, Inc. Compounds containing six-membered rings, processes for their preparation, and their use as medicaments
US20030129146A1 (en) * 1997-10-31 2003-07-10 Vincent Fischetti The use of bacterial phage associated lysing proteins for treating bacterial dental caries
TW477783B (en) * 1997-12-12 2002-03-01 Gilead Sciences Inc Novel compounds useful as neuraminidase inhibitors and pharmaceutical compositions containing same
US6518305B1 (en) 1998-04-23 2003-02-11 Abbott Laboratories Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
WO1999054290A1 (en) * 1998-04-23 1999-10-28 Abbott Laboratories Inhibitors of neuraminidases
US6455571B1 (en) 1998-04-23 2002-09-24 Abbott Laboratories Inhibitors of neuraminidases
TR200100068T2 (tr) 1998-07-15 2001-06-21 Jomaa,Hassan Fosforlu organik bileşikler ve kullanımları
US6303764B1 (en) 1998-09-24 2001-10-16 Zymetx, Inc. Synthesis of 4,7-dialkyl chromogenic glycosides of N-acetylneuraminic acids
US6664235B1 (en) 1999-08-20 2003-12-16 Riken Medicaments comprising sialic acid derivatives as active ingredients
US6420552B1 (en) 1999-09-10 2002-07-16 Zymetx, Inc. Syntheses of 4-alkyl chromogenic glycosides and 7-alkyl chromogenic glycosides of N-acetylneuraminic acids
US6593314B1 (en) 1999-10-19 2003-07-15 Abbott Laboratories Neuraminidase inhibitors
WO2001029020A2 (en) * 1999-10-19 2001-04-26 Abbott Laboratories Neuraminidase inhibitors
US6627396B1 (en) * 1999-10-28 2003-09-30 The Regents Of The University Of California Influenza sensor
JP2004509835A (ja) 2000-03-06 2004-04-02 ユニヴァーシティ　オブ　ケンタッキー　リサーチ　ファンデーション 血液癌前駆細胞を障害する方法およびその関連化合物
GB0015324D0 (en) * 2000-06-22 2000-08-16 Biota Scient Management Medicaments
AUPR001000A0 (en) 2000-09-08 2000-10-05 Biota Scientific Management Pty Ltd Novel chemical compounds and their use
EP1438387A4 (en) * 2001-09-14 2004-10-13 Momenta Pharmaceuticals Inc METHODS OF MAKING GLYCOMOLECULES WITH IMPROVED ACTIVITY, AND USES THEREOF
JP2006241024A (ja) * 2005-03-01 2006-09-14 Takashi Suzuki 新規シアル酸誘導体
TW200811098A (en) 2006-04-27 2008-03-01 Astrazeneca Ab Chemical compounds
CN100471848C (zh) * 2006-06-05 2009-03-25 中国医学科学院医药生物技术研究所 一组长链烷氧烷基取代唾液酸衍生物及其制备方法
US20080063722A1 (en) * 2006-09-08 2008-03-13 Advanced Inhalation Research, Inc. Composition of a Spray-Dried Powder for Pulmonary Delivery of a Long Acting Neuraminidase Inhibitor (LANI)
AU2008208865B2 (en) 2007-01-23 2013-01-24 Therapicon Srl Antiviral compounds
US20080194801A1 (en) * 2007-02-14 2008-08-14 Swanson Basil I Robust multidentate ligands for diagnosis and anti-viral drugs for influenza and related viruses
US7981930B2 (en) * 2007-03-13 2011-07-19 Adamas Pharmaceuticals, Inc. Compositions and kits for treating influenza
US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
PT2137655E (pt) 2007-04-16 2012-09-14 Momenta Pharmaceuticals Inc Produtos de glicoproteína definidos e métodos relacionados
US7888337B2 (en) 2007-08-31 2011-02-15 Academia Sinica Synthesis of oseltamivir containing phosphonate congeners with anti-influenza activity
US20120058937A9 (en) 2008-04-15 2012-03-08 Tsrl, Inc. Prodrugs of Neuraminidase Inhibitors
ES2442024T3 (es) 2008-07-15 2014-02-07 Academia Sinica Matrices de glucano sobre portaobjetos de vidrio revestidos con aluminio de tipo PTFE y métodos relacionados
JP2012510456A (ja) 2008-11-28 2012-05-10 シプラ・リミテッド ザナミビルの製造方法及び該方法に使用するための中間体
TWI491416B (zh) 2008-12-24 2015-07-11 Daiichi Sankyo Co Ltd 吸入用乾燥粉末醫藥組成物
EP2228054A1 (en) 2009-03-13 2010-09-15 ITALFARMACO S.p.A. Riluzole aqueous suspensions
CA3059832C (en) * 2009-05-04 2021-11-23 Ian Schoenhofen Method of producing non-2-enonate compounds
EA201101564A1 (ru) 2009-05-15 2012-07-30 Редкс Фарма Лимитед Редокс производные лекарственных средств
EP2454268B1 (en) 2009-07-15 2014-09-10 The University Of British Columbia 2,3-fluorinated glycosides as neuraminidase inhibitors and their use as anti-virals
US20120202877A1 (en) * 2009-07-16 2012-08-09 Mark Von Itzstein Anti-influenza agents
IT1396620B1 (it) 2009-11-25 2012-12-14 Therapicon Srl Analoghi chimerici
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
JP2011136964A (ja) * 2009-12-28 2011-07-14 Gifu Univ ノイラミン酸誘導体、シアリダーゼ活性阻害剤及び抗インフルエンザ薬
EP2556163B1 (en) 2010-04-07 2016-08-10 Momenta Pharmaceuticals, Inc. Method for quantifying high mannose containing glycoforms
WO2011130332A1 (en) 2010-04-12 2011-10-20 Academia Sinica Glycan arrays for high throughput screening of viruses
KR101745386B1 (ko) 2010-05-10 2017-06-09 아카데미아 시니카 항-인플루엔자 활성을 가진 자나미비르 포스포네이트 동족체 및 인플루엔자 바이러스의 오셀타미비르 감수성을 확인하는 방법
CN101921251B (zh) * 2010-09-21 2011-10-05 仙居县圃瑞药业有限公司 扎那米韦中间体的精制工艺方法
CN102464640A (zh) * 2010-10-29 2012-05-23 江苏正大天晴药业股份有限公司 扎那米韦的制备方法
AT510585B1 (de) 2010-11-18 2012-05-15 Apeptico Forschung & Entwicklung Gmbh Zusammensetzung umfassend ein peptid und ein hemmstoff der viralen neuraminidase
WO2012114350A1 (en) 2011-02-24 2012-08-30 Cadila Healthcare Limited Process for the preparation of zanamivir
CN103782168B (zh) 2011-03-12 2016-03-16 动量制药公司 在糖蛋白产品中包含n-乙酰己糖胺的n-聚醣
WO2012142492A2 (en) * 2011-04-15 2012-10-18 University Of Georgia Research Foundation, Inc. Methods for inhibiting virus replication
KR101369584B1 (ko) 2011-04-19 2014-03-06 일양약품주식회사 페닐-이속사졸 유도체 및 그의 제조방법
WO2013093458A2 (en) 2011-12-21 2013-06-27 Redx Pharma Limited Antiviral drug derivatives
CN107954963A (zh) 2012-01-19 2018-04-24 不列颠哥伦比亚大学 3’平伏氟取代的神经氨酸酶抑制剂化合物、组合物及其用作抗病毒剂的方法
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
US9695244B2 (en) 2012-06-01 2017-07-04 Momenta Pharmaceuticals, Inc. Methods related to denosumab
AU2013306098A1 (en) 2012-08-18 2015-02-12 Academia Sinica Cell-permeable probes for identification and imaging of sialidases
US9227990B2 (en) 2012-10-29 2016-01-05 Cipla Limited Antiviral phosphonate analogues and process for preparation thereof
WO2014149067A1 (en) 2013-03-15 2014-09-25 Momenta Pharmaceuticals, Inc. Methods related to ctla4-fc fusion proteins
ES2708759T3 (es) 2013-05-13 2019-04-11 Momenta Pharmaceuticals Inc Procedimientos para el tratamiento de la neurodegeneración
US10086054B2 (en) 2013-06-26 2018-10-02 Academia Sinica RM2 antigens and use thereof
WO2014210564A1 (en) 2013-06-27 2014-12-31 Academia Sinica Glycan conjugates and use thereof
CN103396957B (zh) * 2013-07-11 2015-08-19 中国海洋大学 一种来源于鲤链霉菌的海洋微生物多糖及其制备方法
JP6486368B2 (ja) 2013-09-06 2019-03-20 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ 改変されたグリコシル基を含む糖脂質を用いたヒトｉＮＫＴ細胞の活性化
CN104418876B (zh) * 2013-09-09 2019-05-17 中国科学院上海有机化学研究所 扎那米韦和拉那米韦的中间体及其合成方法
US20160257754A1 (en) 2013-10-16 2016-09-08 Momenta Pharmaceuticals Inc. Sialylated glycoproteins
JP6453050B2 (ja) * 2013-11-15 2019-01-16 国立大学法人富山大学 ２−デオキシ−２，３−ジデヒドロシアル酸誘導体およびその製造法
US9982041B2 (en) 2014-01-16 2018-05-29 Academia Sinica Compositions and methods for treatment and detection of cancers
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
EP3129767B1 (en) 2014-03-27 2021-09-01 Academia Sinica Reactive labelling compounds and uses thereof
PE20170185A1 (es) 2014-05-12 2017-04-01 Glaxosmithkline Intellectual Property (No 2) Ltd Composiciones farmaceuticas para tratar enfermedades infecciosas
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
KR20240096599A (ko) 2014-05-27 2024-06-26 아카데미아 시니카 항-ｃｄ20 글리코항체 및 이의 용도
CA2950423A1 (en) 2014-05-27 2015-12-03 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
CN106661099A (zh) 2014-05-27 2017-05-10 中央研究院 抗her2醣抗体及其用途
WO2015184001A1 (en) 2014-05-28 2015-12-03 Academia Sinica Anti-tnf-alpha glycoantibodies and uses thereof
NL2013420B1 (en) * 2014-09-05 2016-09-27 Univ Griffith Antiviral agents and uses thereof.
KR102422375B1 (ko) 2014-09-08 2022-07-18 아카데미아 시니카 당지질을 사용한 인간 iNKT 세포 활성화
US10328143B2 (en) 2014-10-24 2019-06-25 Peptidream Inc. Hemagglutinin-binding peptide
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
AU2015378564A1 (en) 2015-01-24 2017-07-13 Academia Sinica Novel glycan conjugates and methods of use thereof
JP2019515876A (ja) 2016-03-08 2019-06-13 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ Ｎ−グリカンおよびそのアレイのモジュール合成のための方法
CA3034057A1 (en) 2016-08-22 2018-03-01 CHO Pharma Inc. Antibodies, binding fragments, and methods of use
CN106520864A (zh) * 2016-09-28 2017-03-22 南京农业大学 一种酶法合成唾液酸类似物的方法及其应用
WO2018213933A1 (en) * 2017-05-25 2018-11-29 The Governors Of The University Of Alberta Methods of preventing or treating atherosclerosis with inhibitors of specific isoenzymes of human neuraminidase
WO2021209563A1 (en) 2020-04-16 2021-10-21 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
WO2023119230A1 (en) 2021-12-22 2023-06-29 L'oreal Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use
WO2023118896A1 (en) 2021-12-23 2023-06-29 Subintro Limited Novel antiviral compositions comprising oleic acid

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