ES8101563A1 - Un procedimiento para la preparacion de nuevos derivados he-terociclicos - Google Patents

Un procedimiento para la preparacion de nuevos derivados he-terociclicos

Info

Publication number
ES8101563A1
ES8101563A1 ES488676A ES488676A ES8101563A1 ES 8101563 A1 ES8101563 A1 ES 8101563A1 ES 488676 A ES488676 A ES 488676A ES 488676 A ES488676 A ES 488676A ES 8101563 A1 ES8101563 A1 ES 8101563A1
Authority
ES
Spain
Prior art keywords
hydrogen
substituted
image
nitrogen atom
atom form
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES488676A
Other languages
English (en)
Other versions
ES488676A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES8101563A1 publication Critical patent/ES8101563A1/es
Publication of ES488676A0 publication Critical patent/ES488676A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/12—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE DERIVADOS HETEROCICLICOS. CONSISTE EN REDUCIR UN COMPUESTO DE FORMULA GENERAL (I) (EN QUE AL MENOS UNO DE LOS RADICALES D, D'' D'''' REPRESENTA UN GRUPO REDUCIBLE). SIENDO DE: R1R2NALQ; D'' REPRESENTA -CH2HH2-, -CONH- O -CH-N-; D'''' REPRESENTA NR4R5 O UN GRUPO -NR4COR1. OPCIONALMENTE SE OBTIENE LA SAL CORRESPONDIENTE DEL COMPUESTO OBTENIDO. *FORMULA* EL COMPUESTO OBTENIDO SE OBTIENE INICIALMENTE COMO BASE LIBRE. TRATAMIENTO DE ULCERAS GASTRICAS Y PEPTICAS, PROFILAXIS DE PROCESOS QUIRURGICOS, TRATAMIENTO DE CONDICIONES ALERGICAS E INFLAMATORIAS DE LA PIEL.
ES488676A 1978-04-26 1980-02-16 Un procedimiento para la preparacion de nuevos derivados he-terociclicos Granted ES488676A0 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1646878 1978-04-26
GB7847689 1978-12-08
GB7907422 1979-03-02

Publications (2)

Publication Number Publication Date
ES8101563A1 true ES8101563A1 (es) 1980-12-16
ES488676A0 ES488676A0 (es) 1980-12-16

Family

ID=27257387

Family Applications (4)

Application Number Title Priority Date Filing Date
ES479988A Granted ES479988A0 (es) 1978-04-26 1979-04-26 Un procedimiento para la preparacion de nuevos derivados - hete rociclicos.
ES488677A Granted ES488677A0 (es) 1978-04-26 1980-02-16 Un procedimiento para la preparacion de nuevos derivados he-terociclicos
ES488676A Granted ES488676A0 (es) 1978-04-26 1980-02-16 Un procedimiento para la preparacion de nuevos derivados he-terociclicos
ES488678A Expired ES8101565A1 (es) 1978-04-26 1980-02-16 Un procedimiento para la preparacion de nuevos derivados he-terociclicos

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES479988A Granted ES479988A0 (es) 1978-04-26 1979-04-26 Un procedimiento para la preparacion de nuevos derivados - hete rociclicos.
ES488677A Granted ES488677A0 (es) 1978-04-26 1980-02-16 Un procedimiento para la preparacion de nuevos derivados he-terociclicos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES488678A Expired ES8101565A1 (es) 1978-04-26 1980-02-16 Un procedimiento para la preparacion de nuevos derivados he-terociclicos

Country Status (20)

Country Link
US (3) US4318913A (es)
AR (1) AR228941A1 (es)
AT (1) AT376212B (es)
AU (1) AU531224B2 (es)
CA (1) CA1143727A (es)
CH (1) CH647767A5 (es)
DE (2) DE2917026A1 (es)
DK (1) DK173579A (es)
ES (4) ES479988A0 (es)
FI (1) FI791360A (es)
FR (1) FR2432511B1 (es)
IL (1) IL57178A (es)
IT (1) IT1162304B (es)
LU (1) LU81192A1 (es)
NL (1) NL7903313A (es)
NO (1) NO791387L (es)
NZ (1) NZ190299A (es)
PH (1) PH19534A (es)
SE (1) SE7903698L (es)
YU (2) YU100379A (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR228941A1 (es) * 1978-04-26 1983-05-13 Glaxo Group Ltd Procedimiento para preparar nuevos derivados de 3,5-diamino-1,2,4-triazol que son activos contra receptores histaminicos
FI68395C (fi) * 1979-03-02 1985-09-10 Glaxo Group Ltd Foerfarande foer framstaellning av farmakologiskt verksamma trazolfoereningar
ES496164A0 (es) * 1979-10-22 1982-04-01 Glaxo Group Ltd Un procedimiento para la produccion de nuevos derivados heterociclicos,.
US4777179A (en) * 1979-10-23 1988-10-11 Glaxo Group Limited Heterocyclic derivatives, processes for the use thereof and pharmaceutical compositions containing them
FR2477150A1 (fr) * 1980-02-28 1981-09-04 Glaxo Group Ltd Nouveaux derives heterocycliques, procedes pour leur preparation et compositions pharmaceutiques les comportant
DE3173130D1 (en) * 1980-08-27 1986-01-16 Glaxo Group Ltd Amino-1,2,4-triazole derivatives, processes for their preparation and pharmaceutical compositions containing them
PT74235B (en) * 1980-12-30 1984-01-04 Glaxo Group Ltd Process for the preparation of a furan derivative
DK558181A (da) * 1981-01-30 1982-07-31 Smithkline Corp Fremgangsmaade til fremstilling af 3,5-diamino-1,2,4-triazoler
US4526973A (en) * 1981-05-18 1985-07-02 Bristol-Myers Company Chemical compounds
US4522943A (en) * 1981-05-18 1985-06-11 Bristol-Myers Company Chemical compounds
IE53068B1 (en) * 1981-06-15 1988-05-25 Merck & Co Inc Diamino isothiazole-1-oxides and -1,1-dioxides as gastic secretion inhibitors
EP0070743A3 (en) * 1981-07-22 1983-10-12 Glaxo Group Limited Pharmaceutical compositions containing compounds having action on histamine receptors
CA1192545A (en) * 1982-02-16 1985-08-27 Glaxo Group Limited Heterocyclic derivatives as histamine h.sub.2- antagonists
US4485104A (en) * 1982-02-24 1984-11-27 Glaxo Group Limited 1,2,4-Triazole-3-amines and their pharmaceutical use
US4482552A (en) * 1982-02-26 1984-11-13 Glaxo Group Limited Triazole compounds and their pharmaceutical use
EP0089765A3 (en) * 1982-03-17 1984-05-23 Smith Kline & French Laboratories Limited Pyridine derivatives
US4520025A (en) * 1982-07-21 1985-05-28 William H. Rorer, Inc. Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses
US4543352A (en) * 1983-04-29 1985-09-24 William H. Rorer, Inc. Naphthalene aminoalkylene ethers and thioethers, and their pharmaceutical uses
US4529723A (en) * 1983-04-29 1985-07-16 William H. Rorer, Inc. Bicyclic benzenoid aminoalkylene ethers and thioethers, pharmaceutical compositions and use
US4481360A (en) * 1983-08-26 1984-11-06 The Upjohn Company 4H-1,2,4-Triazol-3-yl compounds
DE3336410A1 (de) * 1983-10-06 1985-04-18 Ludwig Heumann & Co GmbH, 8500 Nürnberg Sulfenamidderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3404786A1 (de) * 1984-02-10 1985-08-14 Ludwig Heumann & Co GmbH, 8500 Nürnberg Neue alkanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltendes arzneimittel
US4812451A (en) * 1984-10-19 1989-03-14 A. H. Robins Company, Incorporated 1-(aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl)-α,.alpha.
US4812452A (en) * 1984-10-19 1989-03-14 A. H. Robins Company, Incorporated 1-((aminoalkyl and aminoalkylamino) carbonyl and thiocarbonyl)-α,α-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles
EP0226653B1 (de) * 1985-12-20 1989-02-22 LITEF GmbH Verfahren zur Kurswinkelbestimmung mittels und zur automatischen Kalibration eines in einem Luftfahrzeug fest montierten Dreiachsen-Magnetometers
US4988828A (en) * 1987-11-27 1991-01-29 Fujirebio Kabushiki Kaisha Phenoxypropyl derivatives
US5028716A (en) * 1989-01-30 1991-07-02 Taisho Pharmaceutical Co., Ltd. 3,5-diamino-1,2,4-triazole derivatives
GB9009437D0 (en) * 1990-04-26 1990-06-20 Glaxo Group Ltd Chemical compounds
EP4196793A1 (en) 2020-08-11 2023-06-21 Université de Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1419994A (en) 1973-05-03 1976-01-07 Smith Kline French Lab Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them
SU557574A1 (ru) 1975-07-02 1978-03-05 Ордена Трудового Красного Знамени Научно-Исследовательский Институт Экспериментальной Медицины Амн Ссср Способ получени 3-амино-5-(2-аминоэтил)-1,2,4-триазола
SU596577A1 (ru) 1976-02-23 1978-03-05 Ордена Трудового Красного Знамени Научно-Исследовательский Институт Экспериментальной Медицины -Метил- "/4-(5 амино-1,2,4триазолил-3)-бутил/-тиомочевина, про вл юща антигистаминовую активность, и способ ее получени
GB1565966A (en) * 1976-08-04 1980-04-23 Allen & Hanburys Ltd Aminoalkyl furan derivatives
IE46886B1 (en) * 1977-05-17 1983-10-19 Allen & Hanburys Ltd Aminoalkyl-benzene derivatives
GB1601459A (en) * 1977-05-17 1981-10-28 Allen & Hanburys Ltd Aminoalkyl thiophene derivatives
US4115860A (en) * 1977-06-02 1978-09-19 Lockheed Electronics Co., Inc. Plural load power controller with time-shared processor
DE2835695A1 (de) 1977-08-29 1979-03-15 Yamanouchi Pharma Co Ltd Neue heterocyclische verbindungen, verfahren zu ihrer herstellung und arzneimittel, die diese enthalten
AR228941A1 (es) * 1978-04-26 1983-05-13 Glaxo Group Ltd Procedimiento para preparar nuevos derivados de 3,5-diamino-1,2,4-triazol que son activos contra receptores histaminicos
US4293557A (en) * 1979-07-03 1981-10-06 Teikoku Hormone Mfg. Co., Ltd. Antiulcer phenoxypropylamine derivatives
EP0040696B1 (en) * 1980-04-30 1986-08-27 Merck & Co. Inc. Aminothiadiazoles as gastric secretion inhibitors
US4390701A (en) * 1981-05-18 1983-06-28 Bristol-Myers Company 1-Amino-2-[3-(3-piperidinomethylphenoxy)propylamino]cyclobutene-3,4-dione
GR77847B (es) * 1981-12-14 1984-09-25 American Home Prod
JPS6067474A (ja) * 1983-09-24 1985-04-17 Wakamoto Pharmaceut Co Ltd 新規な１，３，４−チアジアゾ−ル誘導体及びそれを有効成分とする抗潰瘍剤
DE3513184A1 (de) * 1985-04-12 1986-10-16 Ludwig Heumann & Co GmbH, 8500 Nürnberg 1,3,4-thiadiazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
FI791360A (fi) 1979-10-27
US4318913A (en) 1982-03-09
YU16183A (en) 1983-04-30
IL57178A (en) 1984-11-30
NZ190299A (en) 1982-05-31
IT7948856A0 (it) 1979-04-26
DE2954639C2 (es) 1990-09-27
NO791387L (no) 1979-10-29
SE7903698L (sv) 1979-10-27
FR2432511A1 (fr) 1980-02-29
LU81192A1 (fr) 1980-05-07
YU100379A (en) 1983-04-30
ES8101564A1 (es) 1980-12-16
CH647767A5 (de) 1985-02-15
DK173579A (da) 1979-10-27
US4764612A (en) 1988-08-16
ES488678A0 (es) 1980-12-16
IL57178A0 (en) 1979-07-25
CA1143727A (en) 1983-03-29
ES8101565A1 (es) 1980-12-16
PH19534A (en) 1986-05-20
DE2917026A1 (de) 1979-11-08
AU4648279A (en) 1979-11-01
ES488676A0 (es) 1980-12-16
ATA316679A (de) 1984-03-15
US4442110A (en) 1984-04-10
ES488677A0 (es) 1980-12-16
AR228941A1 (es) 1983-05-13
NL7903313A (nl) 1979-10-30
FR2432511B1 (fr) 1986-04-25
AU531224B2 (en) 1983-08-18
AT376212B (de) 1984-10-25
ES8102104A1 (es) 1980-08-16
ES479988A0 (es) 1980-08-16
IT1162304B (it) 1987-03-25

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