BG64531B1 - Заместени бензенсулфонамидни производни като прекурсори на cox-2 инхибитори - Google Patents

Заместени бензенсулфонамидни производни като прекурсори на cox-2 инхибитори Download PDF

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BG64531B1
BG64531B1 BG102916A BG10291698A BG64531B1 BG 64531 B1 BG64531 B1 BG 64531B1 BG 102916 A BG102916 A BG 102916A BG 10291698 A BG10291698 A BG 10291698A BG 64531 B1 BG64531 B1 BG 64531B1
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Bulgaria
Prior art keywords
phenyl
sulfonyl
methyl
phenylisoxazol
alkyl
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BG102916A
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Bulgarian (bg)
English (en)
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BG102916A (en
Inventor
John Talley
James Malecha
Stephen Bertenshaw
Matthew Graneto
Jeffrey Carter
Jinglin Li
Srinivasan Nagarajan
David Brown
Jr. Donald Rogier
Thomas Penning
Ish Khanna
Xiangdong Xu
Richard Weier
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G.D.Searle & Co
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Publication of BG102916A publication Critical patent/BG102916A/xx
Publication of BG64531B1 publication Critical patent/BG64531B1/bg

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    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/635Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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    • C07C311/30Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/39Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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BG102916A 1996-04-12 1998-11-12 Заместени бензенсулфонамидни производни като прекурсори на cox-2 инхибитори BG64531B1 (bg)

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US63151496A 1996-04-12 1996-04-12

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