BG61306B1 - Method for the preparation and/or purification of clavulanic acid and its pharmaceutically acceptable salt - Google Patents

Method for the preparation and/or purification of clavulanic acid and its pharmaceutically acceptable salt Download PDF

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Publication number
BG61306B1
BG61306B1 BG99639/95A BG9963995A BG61306B1 BG 61306 B1 BG61306 B1 BG 61306B1 BG 99639/95 A BG99639/95 A BG 99639/95A BG 9963995 A BG9963995 A BG 9963995A BG 61306 B1 BG61306 B1 BG 61306B1
Authority
BG
Bulgaria
Prior art keywords
clavulanic acid
salt
organic solvent
solution
tertiary octylamine
Prior art date
Application number
BG99639/95A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG99639A (bg
Inventor
Michael Allen Cook
Robert Bennett Wilkins
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27450891&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG61306(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB929212379A external-priority patent/GB9212379D0/en
Priority claimed from GB929222841A external-priority patent/GB9222841D0/en
Priority claimed from GB929226061A external-priority patent/GB9226061D0/en
Priority claimed from GB929226282A external-priority patent/GB9226282D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of BG99639A publication Critical patent/BG99639A/bg
Publication of BG61306B1 publication Critical patent/BG61306B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60C—VEHICLE TYRES; TYRE INFLATION; TYRE CHANGING; CONNECTING VALVES TO INFLATABLE ELASTIC BODIES IN GENERAL; DEVICES OR ARRANGEMENTS RELATED TO TYRES
    • B60C27/00—Non-skid devices temporarily attachable to resilient tyres or resiliently-tyred wheels
    • B60C27/006—Non-skid devices temporarily attachable to resilient tyres or resiliently-tyred wheels provided with protective parts, e.g. rubber elements to protect the rim portion
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60C—VEHICLE TYRES; TYRE INFLATION; TYRE CHANGING; CONNECTING VALVES TO INFLATABLE ELASTIC BODIES IN GENERAL; DEVICES OR ARRANGEMENTS RELATED TO TYRES
    • B60C27/00—Non-skid devices temporarily attachable to resilient tyres or resiliently-tyred wheels
    • B60C27/06—Non-skid devices temporarily attachable to resilient tyres or resiliently-tyred wheels extending over the complete circumference of the tread, e.g. made of chains or cables

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BG99639/95A 1992-06-11 1994-10-20 Method for the preparation and/or purification of clavulanic acid and its pharmaceutically acceptable salt BG61306B1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB929212379A GB9212379D0 (en) 1992-06-11 1992-06-11 Novel process
GB929222841A GB9222841D0 (en) 1992-10-31 1992-10-31 Novel process
GB929226061A GB9226061D0 (en) 1992-12-14 1992-12-14 Novel process
GB929226282A GB9226282D0 (en) 1992-12-17 1992-12-17 Novel process
PCT/GB1993/001206 WO1993025557A1 (en) 1992-06-11 1993-06-07 Process for the preparation of clavulanic acid

Publications (2)

Publication Number Publication Date
BG99639A BG99639A (bg) 1996-02-28
BG61306B1 true BG61306B1 (en) 1997-05-30

Family

ID=27450891

Family Applications (3)

Application Number Title Priority Date Filing Date
BG99639/95A BG61306B1 (en) 1992-06-11 1994-10-20 Method for the preparation and/or purification of clavulanic acid and its pharmaceutically acceptable salt
BG99131A BG60999B1 (en) 1992-06-11 1994-10-20 Method for the preparation of clavulanic acid
BG99640A BG61190B1 (bg) 1992-06-11 1995-05-16 Метод за получаване и/или пречистване на клавуланова киселина или нейна фармацевтично приемлива сол или естер

Family Applications After (2)

Application Number Title Priority Date Filing Date
BG99131A BG60999B1 (en) 1992-06-11 1994-10-20 Method for the preparation of clavulanic acid
BG99640A BG61190B1 (bg) 1992-06-11 1995-05-16 Метод за получаване и/или пречистване на клавуланова киселина или нейна фармацевтично приемлива сол или естер

Country Status (35)

Country Link
EP (7) EP0747383A3 (ja)
JP (3) JPH07507324A (ja)
KR (1) KR0162264B1 (ja)
CN (3) CN1037967C (ja)
AP (3) AP473A (ja)
AT (3) ATE157981T1 (ja)
AU (3) AU4342793A (ja)
BG (3) BG61306B1 (ja)
CA (2) CA2160768A1 (ja)
CS (1) CS202194A3 (ja)
CY (1) CY1895A (ja)
CZ (5) CZ267594A3 (ja)
DE (6) DE69306574T2 (ja)
DK (5) DK0672670T3 (ja)
ES (3) ES2106615T3 (ja)
FI (7) FI944031A (ja)
GB (2) GB2287025B (ja)
GR (4) GR950300070T1 (ja)
HK (4) HK6996A (ja)
HU (3) HUT69374A (ja)
IL (1) IL105966A (ja)
LU (1) LU88567A1 (ja)
MA (1) MA22907A1 (ja)
MX (1) MX9303441A (ja)
MY (1) MY131501A (ja)
NL (1) NL9320037A (ja)
NO (3) NO943093L (ja)
PT (2) PT101710A (ja)
RO (3) RO111193B1 (ja)
RU (1) RU2081121C1 (ja)
SE (5) SE9404290L (ja)
SI (1) SI9300296B (ja)
SK (3) SK278367B6 (ja)
UY (1) UY24154A1 (ja)
WO (1) WO1993025557A1 (ja)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (de) 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
AT399155B (de) * 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
KR100200239B1 (ko) * 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
US5821364A (en) * 1993-03-26 1998-10-13 Gist-Brocades N.V. Diamine salts of clavulanic acid
US5741903A (en) * 1993-03-26 1998-04-21 Gist-Brocades N.V. Diamine salts for purification of clavulanic acid
RO112113B1 (ro) * 1993-03-26 1997-05-30 Gist Brocades Nv Saruri diaminice ale acidului clavulanic si procedeu pentru prepararea acestora
US5760218A (en) * 1993-03-26 1998-06-02 Gist-Brocades N.V. Diamine salts of clavulanic acid
DK0658558T3 (da) 1993-11-17 2001-04-17 Biochemie Gmbh Adskillelse af cephalosporinisomere
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9426261D0 (en) * 1994-12-24 1995-02-22 Spurcourt Ltd Clavulanic acid salts
PL321871A1 (en) * 1995-02-25 1997-12-22 Spurcourt Ltd Clavulanic salts and compositions containing them as well as method of obtaining such salts
SI9500134B (sl) 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
SI9500265A1 (en) 1995-08-28 1997-02-28 Lek Tovarna Farmacevtskih Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
ZA975198B (en) * 1996-06-13 1997-12-15 Smithkline Beecham Corp Improved process for preparing potassium clavulanate.
PL333247A1 (en) * 1996-11-11 1999-11-22 Gist Brocades Bv Method of manufacturing of salts and esters of clavulan acid
AT404728B (de) * 1996-11-27 1999-02-25 Biochemie Gmbh Verfahren zur herstellung von clavulansäure-aminsalzen
DZ2456A1 (fr) * 1997-04-04 2003-01-18 Smithkline Beecham Plc Procédé de préparation de sels de l'acide clavulanique.
EP1095046A1 (en) * 1998-07-16 2001-05-02 Dsm N.V. Improved process for the preparation of salts and esters of clavulanic acid
US6440708B1 (en) * 1998-09-29 2002-08-27 Dsm N.V. Fermentation of clavulanic acid at a controlled level of ammonia
DE19917428A1 (de) * 1999-04-19 2000-10-26 Clariant Gmbh Flammwidrige phosphormodifizierte Epoxidharze
GB0003305D0 (en) 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
WO2001087891A1 (en) 2000-05-13 2001-11-22 Smithkline Beecham P.L.C. Process for the purification of a salt of clavulanic acid
ITMI20011764A1 (it) * 2001-08-10 2003-02-10 Dinamite Dipharma Spa Metodo per l'ottenimento del pemirolast ad elevata purezza
GB201010439D0 (en) * 2010-06-21 2010-08-04 Arch Timber Protection Ltd A method
CN103304583B (zh) * 2013-07-09 2016-01-20 山东新时代药业有限公司 一种从克拉维酸胺盐结晶母液中回收克拉维酸的方法
CN105384758B (zh) * 2015-12-01 2018-05-01 国药集团威奇达药业有限公司 克拉维酸胺盐的制备方法
EP3613866B1 (en) 2017-04-19 2022-12-14 Nippon Light Metal Company, Ltd. Al-si-fe aluminum alloy casting material and production method therefor
CN109305978A (zh) * 2017-07-26 2019-02-05 山东睿鹰先锋制药有限公司 一种制备克拉维酸盐的新方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508977A (en) 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
GB1507978A (en) 1974-03-28 1978-04-19 Dunlop Ltd Pneumatic tyre and wheel rim assemblies
GB1543563A (en) 1975-02-07 1979-04-04 Glaxo Lab Ltd Beta-lactam antibiotic in purified form
GB1508978A (en) 1975-04-11 1978-04-26 Beecham Group Ltd Esters of clavulanic acid
GB1578739A (en) 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
EP0002312B1 (en) * 1977-11-26 1982-02-03 Beecham Group Plc Derivatives of clavulanic acid and pharmaceutical compositions containing them
BE862211A (fr) 1977-12-22 1978-06-22 Beecham Group Ltd Agents antibacteriens
JPS5562993A (en) 1978-11-07 1980-05-12 Idemitsu Petrochem Co Ltd Operation of olefin manufacturing equipment
JPS55162993A (en) * 1979-06-07 1980-12-18 Sanraku Inc Preparation of culavulanic acid
DE3063683D1 (en) * 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
AR245221A1 (es) * 1984-10-27 1993-12-30 Beecham Group Plc Un metodo para la produccion de acido clavulanico por fermentacion de s. clavuligerus
ES2010143A6 (es) 1989-03-01 1989-10-16 Pharma Mar S A Pharmar Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.
FR2644543A1 (ja) 1989-03-17 1990-09-21 Renault
PT94908B (pt) 1990-08-03 1998-05-29 Portela & Ca Lda Processo para a preparacao de derivados carboxilicos beta-lactamicos altamente purificados estaveis e hipoalergenicos
AT400033B (de) * 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
AT399155B (de) * 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl) 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
KR100200239B1 (ko) * 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
GB9305565D0 (en) * 1993-03-18 1993-05-05 Smithkline Beecham Plc Novel compounds and processes
RO112113B1 (ro) * 1993-03-26 1997-05-30 Gist Brocades Nv Saruri diaminice ale acidului clavulanic si procedeu pentru prepararea acestora
EP0887178A1 (de) 1997-06-27 1998-12-30 Pamag Ag Verfahren zum Bündeln von Seitenfaltbeuteln und Vorrichtung zur Durchführung des Verfahrens

Also Published As

Publication number Publication date
DE4345311C1 (de) 1996-02-01
SK278520B6 (en) 1997-08-06
FI961739A0 (fi) 1996-04-22
AP474A (en) 1996-03-06
CZ267694A3 (en) 1997-08-13
EP0672670B1 (en) 1996-02-14
DE4392664T1 (de) 1995-06-01
CA2117538A1 (en) 1993-12-23
FI103973B1 (fi) 1999-10-29
CZ281102B6 (cs) 1996-06-12
GB2287026B (en) 1995-11-01
SE9404290L (sv) 1995-01-16
PT101711A (pt) 1995-12-29
FI951414A0 (fi) 1995-03-24
AU665159B2 (en) 1995-12-14
NO943093L (no) 1994-12-09
DE69313869D1 (de) 1997-10-16
FI980630A0 (fi) 1998-03-20
EP0747383A2 (en) 1996-12-11
MX9303441A (es) 1994-03-31
ES2095059T3 (es) 1997-02-01
AU1786595A (en) 1995-07-06
NO950758L (no) 1994-12-09
EP0806426A1 (en) 1997-11-12
RO111192B1 (ro) 1996-07-30
SK153394A3 (en) 1995-05-10
SE9600797D0 (sv) 1996-02-29
SE504220C2 (sv) 1996-12-09
NO178499C (no) 1997-04-01
FI944031A0 (fi) 1994-09-02
AU681569B3 (en) 1997-08-28
FI980630A (fi) 1998-03-20
PT101710A (pt) 1995-12-29
RU95112522A (ru) 1997-02-10
GR950300070T1 (en) 1996-01-31
SK278561B6 (en) 1997-10-08
NO951725L (no) 1994-12-09
EP0672669B1 (en) 1997-09-10
RO111193B1 (ro) 1996-07-30
DE4345286A1 (de) 1995-09-21
GB2287025A (en) 1995-09-06
HU9501214D0 (en) 1995-06-28
HK1007311A1 (en) 1999-04-09
FI980631A0 (fi) 1998-03-20
SE9600797L (sv) 1996-02-29
RU2081121C1 (ru) 1997-06-10
EP0644887A1 (en) 1995-03-29
HK1003222A1 (en) 1998-10-16
HK6996A (en) 1996-01-19
CZ125495A3 (en) 1996-06-12
JPH08157480A (ja) 1996-06-18
SK99494A3 (en) 1995-04-12
CN1095069A (zh) 1994-11-16
FI982790A (fi) 1998-12-23
ATE134192T1 (de) 1996-02-15
AP471A (en) 1996-03-06
GB2287025B (en) 1997-02-26
FI96952B (fi) 1996-06-14
GB9508497D0 (en) 1995-06-14
AU1473795A (en) 1995-06-22
LU88567A1 (fr) 1995-06-01
GR3019006T3 (en) 1996-05-31
HU212583B (en) 1996-08-29
CN1037967C (zh) 1998-04-08
IL105966A (en) 1997-09-30
DK170569B1 (da) 1995-10-23
CS202194A3 (cs) 1994-12-15
DK0644887T3 (da) 1997-06-02
GR3022006T3 (en) 1997-03-31
BG99640A (bg) 1996-02-28
SE9704244D0 (sv) 1997-11-19
EP0644887B1 (en) 1996-12-11
KR0162264B1 (ko) 1998-12-01
EP0699682A1 (en) 1996-03-06
FI982790A0 (fi) 1998-12-23
CN1112928A (zh) 1995-12-06
CN1041934C (zh) 1999-02-03
ES2080710T1 (es) 1996-02-16
HU9402405D0 (en) 1994-10-28
HUT68775A (en) 1995-07-28
BG60999B1 (en) 1996-08-30
ES2080710T3 (es) 1996-05-16
FI980631A (fi) 1998-03-20
SE9500718L (sv) 1995-02-27
FI952820A (fi) 1995-06-08
WO1993025557A1 (en) 1993-12-23
MA22907A1 (fr) 1993-12-31
EP0672669A1 (en) 1995-09-20
DE69313869T2 (de) 1998-01-29
FI944031A (fi) 1994-10-24
HK1003245A1 (en) 1998-10-16
JPH07507324A (ja) 1995-08-10
NO950758D0 (no) 1995-02-27
CN1036592C (zh) 1997-12-03
FI961739A (fi) 1996-04-22
GR3024666T3 (en) 1997-12-31
FI951414A (fi) 1995-03-24
FI952820A0 (fi) 1995-06-08
FI103973B (fi) 1999-10-29
HUT69374A (en) 1995-09-28
CZ19396A3 (en) 1997-08-13
ATE146180T1 (de) 1996-12-15
GB9508496D0 (en) 1995-06-14
SE9500718D0 (sv) 1995-02-27
AU1471697A (en) 1997-05-22
DE69306574D1 (de) 1997-01-23
BG99639A (bg) 1996-02-28
JPH08134072A (ja) 1996-05-28
DK0672669T3 (da) 1997-12-22
DE69301571D1 (de) 1996-03-28
SE9501544L (sv) 1995-04-26
MY131501A (en) 2007-08-30
BG99131A (bg) 1995-08-28
ES2106615T3 (es) 1997-11-01
SE9404290D0 (sv) 1994-12-09
SE9501544D0 (sv) 1995-04-26
DK140694A (da) 1994-12-08
CZ54495A3 (en) 1997-08-13
UY24154A1 (es) 1996-07-23
CA2160768A1 (en) 1993-12-12
SE503077C2 (sv) 1996-03-18
AU680099B2 (en) 1997-07-17
BG61190B1 (bg) 1997-02-28
KR950700914A (ko) 1995-02-20
NO178499B (no) 1996-01-02
HU9500610D0 (en) 1995-04-28
NL9320037A (nl) 1995-06-01
GB2287026A (en) 1995-09-06
ATE157981T1 (de) 1997-09-15
AP9300537A0 (en) 1993-07-31
FI96952C (fi) 1998-05-20
DK0672670T3 (da) 1996-03-25
CZ267594A3 (en) 1997-08-13
DE69306574T2 (de) 1997-04-30
SI9300296A (en) 1993-12-31
AU4342793A (en) 1994-01-04
EP0672670A1 (en) 1995-09-20
IL105966A0 (en) 1993-10-20
EP0801069A1 (en) 1997-10-15
NO943093D0 (no) 1994-08-22
RO111191B1 (ro) 1996-07-30
SK153294A3 (en) 1995-05-10
DE69301571T2 (de) 1996-07-18
AP473A (en) 1996-03-06
EP0747383A3 (en) 1996-12-18
SI9300296B (sl) 1998-06-30
NO951725D0 (no) 1995-05-03
DK68595A (da) 1995-06-15
CY1895A (en) 1996-09-27
SK278367B6 (en) 1997-01-08
CN1113244A (zh) 1995-12-13
FI104488B (fi) 2000-02-15

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