ATE146180T1 - Zwischenprodukte in einem verfahren zur reinigung von clavulansäure - Google Patents

Zwischenprodukte in einem verfahren zur reinigung von clavulansäure

Info

Publication number
ATE146180T1
ATE146180T1 AT93913311T AT93913311T ATE146180T1 AT E146180 T1 ATE146180 T1 AT E146180T1 AT 93913311 T AT93913311 T AT 93913311T AT 93913311 T AT93913311 T AT 93913311T AT E146180 T1 ATE146180 T1 AT E146180T1
Authority
AT
Austria
Prior art keywords
intermediate products
clavulanic acid
purifying clavulanic
purifying
acid
Prior art date
Application number
AT93913311T
Other languages
English (en)
Inventor
Michael Allen Cook
Robert Bennett Wilkins
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27450891&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE146180(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB929212379A external-priority patent/GB9212379D0/en
Priority claimed from GB929222841A external-priority patent/GB9222841D0/en
Priority claimed from GB929226061A external-priority patent/GB9226061D0/en
Priority claimed from GB929226282A external-priority patent/GB9226282D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Application granted granted Critical
Publication of ATE146180T1 publication Critical patent/ATE146180T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60C—VEHICLE TYRES; TYRE INFLATION; TYRE CHANGING; CONNECTING VALVES TO INFLATABLE ELASTIC BODIES IN GENERAL; DEVICES OR ARRANGEMENTS RELATED TO TYRES
    • B60C27/00—Non-skid devices temporarily attachable to resilient tyres or resiliently-tyred wheels
    • B60C27/006—Non-skid devices temporarily attachable to resilient tyres or resiliently-tyred wheels provided with protective parts, e.g. rubber elements to protect the rim portion
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60C—VEHICLE TYRES; TYRE INFLATION; TYRE CHANGING; CONNECTING VALVES TO INFLATABLE ELASTIC BODIES IN GENERAL; DEVICES OR ARRANGEMENTS RELATED TO TYRES
    • B60C27/00—Non-skid devices temporarily attachable to resilient tyres or resiliently-tyred wheels
    • B60C27/06—Non-skid devices temporarily attachable to resilient tyres or resiliently-tyred wheels extending over the complete circumference of the tread, e.g. made of chains or cables
AT93913311T 1992-06-11 1993-06-07 Zwischenprodukte in einem verfahren zur reinigung von clavulansäure ATE146180T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB929212379A GB9212379D0 (en) 1992-06-11 1992-06-11 Novel process
GB929222841A GB9222841D0 (en) 1992-10-31 1992-10-31 Novel process
GB929226061A GB9226061D0 (en) 1992-12-14 1992-12-14 Novel process
GB929226282A GB9226282D0 (en) 1992-12-17 1992-12-17 Novel process

Publications (1)

Publication Number Publication Date
ATE146180T1 true ATE146180T1 (de) 1996-12-15

Family

ID=27450891

Family Applications (3)

Application Number Title Priority Date Filing Date
AT95201085T ATE134192T1 (de) 1992-06-11 1993-06-07 Verfahren zur herstellung von clavulansäure
AT95201084T ATE157981T1 (de) 1992-06-11 1993-06-07 Verfahren zur herstellung von kalium clavulanat
AT93913311T ATE146180T1 (de) 1992-06-11 1993-06-07 Zwischenprodukte in einem verfahren zur reinigung von clavulansäure

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AT95201085T ATE134192T1 (de) 1992-06-11 1993-06-07 Verfahren zur herstellung von clavulansäure
AT95201084T ATE157981T1 (de) 1992-06-11 1993-06-07 Verfahren zur herstellung von kalium clavulanat

Country Status (35)

Country Link
EP (7) EP0806426A1 (de)
JP (3) JPH07507324A (de)
KR (1) KR0162264B1 (de)
CN (3) CN1037967C (de)
AP (3) AP471A (de)
AT (3) ATE134192T1 (de)
AU (3) AU4342793A (de)
BG (3) BG60999B1 (de)
CA (2) CA2117538A1 (de)
CS (1) CS202194A3 (de)
CY (1) CY1895A (de)
CZ (5) CZ125495A3 (de)
DE (6) DE4345286A1 (de)
DK (5) DK0672669T3 (de)
ES (3) ES2095059T3 (de)
FI (7) FI944031A (de)
GB (2) GB2287026B (de)
GR (4) GR950300070T1 (de)
HK (4) HK6996A (de)
HU (3) HU212583B (de)
IL (1) IL105966A (de)
LU (1) LU88567A1 (de)
MA (1) MA22907A1 (de)
MX (1) MX9303441A (de)
MY (1) MY131501A (de)
NL (1) NL9320037A (de)
NO (3) NO943093L (de)
PT (2) PT101710A (de)
RO (3) RO111191B1 (de)
RU (1) RU2081121C1 (de)
SE (5) SE9404290L (de)
SI (1) SI9300296B (de)
SK (3) SK278367B6 (de)
UY (1) UY24154A1 (de)
WO (1) WO1993025557A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (de) 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
AT399155B (de) * 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
KR100200239B1 (ko) * 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
AU682030B2 (en) * 1993-03-26 1997-09-18 Dsm N.V. Diamine salts of clavulanic acid
US5741903A (en) * 1993-03-26 1998-04-21 Gist-Brocades N.V. Diamine salts for purification of clavulanic acid
US5821364A (en) * 1993-03-26 1998-10-13 Gist-Brocades N.V. Diamine salts of clavulanic acid
US5760218A (en) * 1993-03-26 1998-06-02 Gist-Brocades N.V. Diamine salts of clavulanic acid
EP0658558B1 (de) 1993-11-17 2001-01-24 Biochemie Gesellschaft M.B.H. Trennung von Cephalosporinisomeren
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9426261D0 (en) * 1994-12-24 1995-02-22 Spurcourt Ltd Clavulanic acid salts
AP9701116A0 (en) * 1995-02-25 1997-10-31 Spurcourt Ltd Clavulanic acid salts
SI9500134B (sl) * 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
SI9500265A1 (en) 1995-08-28 1997-02-28 Lek Tovarna Farmacevtskih Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
ZA975198B (en) * 1996-06-13 1997-12-15 Smithkline Beecham Corp Improved process for preparing potassium clavulanate.
EP0937084A1 (de) * 1996-11-11 1999-08-25 Gist-Brocades B.V. Verfahren zur herstellung von clavulansäure-salzen und estern
AT404728B (de) * 1996-11-27 1999-02-25 Biochemie Gmbh Verfahren zur herstellung von clavulansäure-aminsalzen
DZ2456A1 (fr) 1997-04-04 2003-01-18 Smithkline Beecham Plc Procédé de préparation de sels de l'acide clavulanique.
EP1095046A1 (de) * 1998-07-16 2001-05-02 Dsm N.V. Verbessertes verfahren zur herstellung von clavulansäure-salzen und -estern
US6440708B1 (en) 1998-09-29 2002-08-27 Dsm N.V. Fermentation of clavulanic acid at a controlled level of ammonia
DE19917428A1 (de) * 1999-04-19 2000-10-26 Clariant Gmbh Flammwidrige phosphormodifizierte Epoxidharze
GB0003305D0 (en) 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
CN1222528C (zh) 2000-05-13 2005-10-12 史密斯克莱·比奇曼公司 提纯克拉布兰酸盐的方法
ITMI20011764A1 (it) * 2001-08-10 2003-02-10 Dinamite Dipharma Spa Metodo per l'ottenimento del pemirolast ad elevata purezza
GB201010439D0 (en) * 2010-06-21 2010-08-04 Arch Timber Protection Ltd A method
CN103304583B (zh) * 2013-07-09 2016-01-20 山东新时代药业有限公司 一种从克拉维酸胺盐结晶母液中回收克拉维酸的方法
CN105384758B (zh) * 2015-12-01 2018-05-01 国药集团威奇达药业有限公司 克拉维酸胺盐的制备方法
US11603582B2 (en) 2017-04-19 2023-03-14 Nippon Light Metal Company, Ltd. Al—Si—Fe-based aluminum alloy casting material and method for producing the same
CN109305978A (zh) * 2017-07-26 2019-02-05 山东睿鹰先锋制药有限公司 一种制备克拉维酸盐的新方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508977A (en) * 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
GB1507978A (en) 1974-03-28 1978-04-19 Dunlop Ltd Pneumatic tyre and wheel rim assemblies
GB1543563A (en) 1975-02-07 1979-04-04 Glaxo Lab Ltd Beta-lactam antibiotic in purified form
GB1508978A (en) 1975-04-11 1978-04-26 Beecham Group Ltd Esters of clavulanic acid
GB1578739A (en) * 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
EP0002312B1 (de) * 1977-11-26 1982-02-03 Beecham Group Plc Clavulansäure-derivate sowie sie enthaltende pharmazeutische Zusammensetzungen
BE862211A (fr) 1977-12-22 1978-06-22 Beecham Group Ltd Agents antibacteriens
JPS5562993A (en) 1978-11-07 1980-05-12 Idemitsu Petrochem Co Ltd Operation of olefin manufacturing equipment
JPS55162993A (en) 1979-06-07 1980-12-18 Sanraku Inc Preparation of culavulanic acid
DE3063683D1 (en) 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
MX7417E (es) * 1984-10-27 1988-10-14 Antibioticos Sa Metodo para la preparacion de acido clavulanico y sus derivados
ES2010143A6 (es) * 1989-03-01 1989-10-16 Pharma Mar S A Pharmar Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.
FR2644543A1 (de) 1989-03-17 1990-09-21 Renault
PT94908B (pt) 1990-08-03 1998-05-29 Portela & Ca Lda Processo para a preparacao de derivados carboxilicos beta-lactamicos altamente purificados estaveis e hipoalergenicos
AT400033B (de) * 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
AT399155B (de) * 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
KR100200239B1 (ko) * 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
GB9305565D0 (en) * 1993-03-18 1993-05-05 Smithkline Beecham Plc Novel compounds and processes
AU682030B2 (en) * 1993-03-26 1997-09-18 Dsm N.V. Diamine salts of clavulanic acid
EP0887178A1 (de) 1997-06-27 1998-12-30 Pamag Ag Verfahren zum Bündeln von Seitenfaltbeuteln und Vorrichtung zur Durchführung des Verfahrens

Also Published As

Publication number Publication date
SE503077C2 (sv) 1996-03-18
JPH07507324A (ja) 1995-08-10
CZ19396A3 (en) 1997-08-13
AP471A (en) 1996-03-06
HU9402405D0 (en) 1994-10-28
RO111192B1 (ro) 1996-07-30
HU9500610D0 (en) 1995-04-28
AU4342793A (en) 1994-01-04
RU2081121C1 (ru) 1997-06-10
ES2095059T3 (es) 1997-02-01
SE9600797L (sv) 1996-02-29
GB2287026A (en) 1995-09-06
HK1003222A1 (en) 1998-10-16
FI980630A0 (fi) 1998-03-20
CZ281102B6 (cs) 1996-06-12
AU1471697A (en) 1997-05-22
SI9300296A (en) 1993-12-31
EP0672670B1 (de) 1996-02-14
CS202194A3 (cs) 1994-12-15
AU665159B2 (en) 1995-12-14
AP474A (en) 1996-03-06
CZ267594A3 (en) 1997-08-13
BG61306B1 (en) 1997-05-30
NO943093L (no) 1994-12-09
SE9404290L (sv) 1995-01-16
KR950700914A (ko) 1995-02-20
SE9500718L (sv) 1995-02-27
AU680099B2 (en) 1997-07-17
FI980631A0 (fi) 1998-03-20
EP0672669B1 (de) 1997-09-10
DE69301571T2 (de) 1996-07-18
DE4392664T1 (de) 1995-06-01
FI952820A0 (fi) 1995-06-08
HK6996A (en) 1996-01-19
CA2160768A1 (en) 1993-12-12
MY131501A (en) 2007-08-30
EP0806426A1 (de) 1997-11-12
GB9508496D0 (en) 1995-06-14
DK140694A (da) 1994-12-08
HUT68775A (en) 1995-07-28
JPH08157480A (ja) 1996-06-18
EP0801069A1 (de) 1997-10-15
SE9404290D0 (sv) 1994-12-09
DK0672669T3 (da) 1997-12-22
FI103973B1 (fi) 1999-10-29
LU88567A1 (fr) 1995-06-01
SK278561B6 (en) 1997-10-08
FI952820A (fi) 1995-06-08
SE9501544L (sv) 1995-04-26
KR0162264B1 (ko) 1998-12-01
NO950758L (no) 1994-12-09
RO111191B1 (ro) 1996-07-30
CZ125495A3 (en) 1996-06-12
HU212583B (en) 1996-08-29
EP0672670A1 (de) 1995-09-20
NO178499C (no) 1997-04-01
EP0747383A3 (de) 1996-12-18
GB2287025B (en) 1997-02-26
PT101711A (pt) 1995-12-29
SK153294A3 (en) 1995-05-10
DE4345311C1 (de) 1996-02-01
ATE157981T1 (de) 1997-09-15
SE9501544D0 (sv) 1995-04-26
GR3024666T3 (en) 1997-12-31
BG99131A (bg) 1995-08-28
SE504220C2 (sv) 1996-12-09
RO111193B1 (ro) 1996-07-30
WO1993025557A1 (en) 1993-12-23
NO951725L (no) 1994-12-09
AU1473795A (en) 1995-06-22
HK1007311A1 (en) 1999-04-09
EP0699682A1 (de) 1996-03-06
GB2287025A (en) 1995-09-06
DK68595A (da) 1995-06-15
EP0747383A2 (de) 1996-12-11
SE9500718D0 (sv) 1995-02-27
BG99640A (bg) 1996-02-28
EP0672669A1 (de) 1995-09-20
CY1895A (en) 1996-09-27
FI951414A0 (fi) 1995-03-24
SK278367B6 (en) 1997-01-08
FI961739A (fi) 1996-04-22
SE9704244D0 (sv) 1997-11-19
CN1036592C (zh) 1997-12-03
MX9303441A (es) 1994-03-31
EP0644887A1 (de) 1995-03-29
EP0644887B1 (de) 1996-12-11
FI961739A0 (fi) 1996-04-22
SE9600797D0 (sv) 1996-02-29
AU681569B3 (en) 1997-08-28
FI104488B (fi) 2000-02-15
FI944031A (fi) 1994-10-24
ES2080710T3 (es) 1996-05-16
FI103973B (fi) 1999-10-29
SI9300296B (sl) 1998-06-30
DE69313869D1 (de) 1997-10-16
CZ267694A3 (en) 1997-08-13
GB9508497D0 (en) 1995-06-14
NO943093D0 (no) 1994-08-22
CZ54495A3 (en) 1997-08-13
GB2287026B (en) 1995-11-01
BG99639A (bg) 1996-02-28
MA22907A1 (fr) 1993-12-31
FI980630A (fi) 1998-03-20
CN1112928A (zh) 1995-12-06
NO178499B (no) 1996-01-02
BG60999B1 (en) 1996-08-30
DK0644887T3 (da) 1997-06-02
GR950300070T1 (en) 1996-01-31
CN1113244A (zh) 1995-12-13
SK153394A3 (en) 1995-05-10
GR3022006T3 (en) 1997-03-31
DK170569B1 (da) 1995-10-23
FI980631A (fi) 1998-03-20
RU95112522A (ru) 1997-02-10
ES2080710T1 (es) 1996-02-16
BG61190B1 (bg) 1997-02-28
FI982790A0 (fi) 1998-12-23
DE4345286A1 (de) 1995-09-21
DE69306574D1 (de) 1997-01-23
CN1037967C (zh) 1998-04-08
DE69306574T2 (de) 1997-04-30
ES2106615T3 (es) 1997-11-01
AU1786595A (en) 1995-07-06
HK1003245A1 (en) 1998-10-16
JPH08134072A (ja) 1996-05-28
CA2117538A1 (en) 1993-12-23
NO950758D0 (no) 1995-02-27
PT101710A (pt) 1995-12-29
FI982790A (fi) 1998-12-23
FI96952C (fi) 1998-05-20
AP9300537A0 (en) 1993-07-31
UY24154A1 (es) 1996-07-23
SK99494A3 (en) 1995-04-12
IL105966A0 (en) 1993-10-20
AP473A (en) 1996-03-06
HUT69374A (en) 1995-09-28
DK0672670T3 (da) 1996-03-25
HU9501214D0 (en) 1995-06-28
CN1095069A (zh) 1994-11-16
ATE134192T1 (de) 1996-02-15
CN1041934C (zh) 1999-02-03
SK278520B6 (en) 1997-08-06
IL105966A (en) 1997-09-30
FI96952B (fi) 1996-06-14
DE69301571D1 (de) 1996-03-28
FI944031A0 (fi) 1994-09-02
GR3019006T3 (en) 1996-05-31
FI951414A (fi) 1995-03-24
DE69313869T2 (de) 1998-01-29
NL9320037A (nl) 1995-06-01
NO951725D0 (no) 1995-05-03

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee