TR200100082T2 - Klavulanik asit tuz ve esterlerinin hazırlanması için geliştirilmiş yöntem - Google Patents
Klavulanik asit tuz ve esterlerinin hazırlanması için geliştirilmiş yöntemInfo
- Publication number
- TR200100082T2 TR200100082T2 TR2001/00082T TR200100082T TR200100082T2 TR 200100082 T2 TR200100082 T2 TR 200100082T2 TR 2001/00082 T TR2001/00082 T TR 2001/00082T TR 200100082 T TR200100082 T TR 200100082T TR 200100082 T2 TR200100082 T2 TR 200100082T2
- Authority
- TR
- Turkey
- Prior art keywords
- clavulanic acid
- esters
- amine
- preparation
- acid salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Klavulanik asidin bir amin tuzunun üretimi ve bunlarin farmakolojik olarak kabul edilebilir tuz ve esterlerine dönüsmesi için saglanan bir islemdir. Klavulanik asidin amin tuzunun kristallestirilmesi safhasi süresince, ya çözelti ihtiva eden klavulanik asit, seçimlik olarak bir yardimci çözücü ile, amine eklenir veya her iki tepkileyici kristallestirme kabina birlikte eklenirler. Bu kristallestirme islemi için ayrica sicaklik profili(zamanla azalan), ekleme hizi profili, amin/klavulanik asit orani profili(zamanla artan) uygulamasi saglanmistir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98202390 | 1998-07-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200100082T2 true TR200100082T2 (tr) | 2001-06-21 |
Family
ID=8233939
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2001/00082T TR200100082T2 (tr) | 1998-07-16 | 1999-07-13 | Klavulanik asit tuz ve esterlerinin hazırlanması için geliştirilmiş yöntem |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1095046A1 (tr) |
CN (1) | CN1312814A (tr) |
AU (1) | AU5411099A (tr) |
CA (1) | CA2337072A1 (tr) |
TR (1) | TR200100082T2 (tr) |
WO (1) | WO2000004028A1 (tr) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1284978B2 (en) * | 2000-05-13 | 2008-09-10 | Smithkline Beecham Plc | Process for the purification of a salt of clavulanic acid |
CN101548018A (zh) * | 2006-12-01 | 2009-09-30 | 帝斯曼知识产权资产管理有限公司 | 一种用于制备克拉维酸的方法 |
CN103304583B (zh) * | 2013-07-09 | 2016-01-20 | 山东新时代药业有限公司 | 一种从克拉维酸胺盐结晶母液中回收克拉维酸的方法 |
CN104450813B (zh) * | 2014-11-22 | 2017-04-12 | 太原理工大学 | 一种二苯甲胺的合成方法 |
CN109305978A (zh) * | 2017-07-26 | 2019-02-05 | 山东睿鹰先锋制药有限公司 | 一种制备克拉维酸盐的新方法 |
CN109535184B (zh) * | 2017-09-21 | 2020-11-20 | 联邦制药(内蒙古)有限公司 | 一种克拉维酸叔辛胺制备克拉维酸钾的方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1578739A (en) * | 1976-07-23 | 1980-11-05 | Beecham Group Ltd | Amine salts of clavulanic acid methods for their preparation and compositions containing them |
ES2010143A6 (es) * | 1989-03-01 | 1989-10-16 | Pharma Mar S A Pharmar | Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp. |
AT400033B (de) * | 1992-03-10 | 1995-09-25 | Biochemie Gmbh | Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben |
AT399155B (de) * | 1992-03-26 | 1995-03-27 | Lek Tovarna Farmacevtskih | Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung |
SI9300296B (sl) * | 1992-06-11 | 1998-06-30 | Smithkline Beecham P.L.C. | Postopek in intermedianti za pripravo klavulanske kisline |
KR100200239B1 (ko) * | 1992-10-21 | 1999-06-15 | 김충환 | 클라불란산 칼륨염의 제조방법 |
GB9305565D0 (en) * | 1993-03-18 | 1993-05-05 | Smithkline Beecham Plc | Novel compounds and processes |
US5741903A (en) * | 1993-03-26 | 1998-04-21 | Gist-Brocades N.V. | Diamine salts for purification of clavulanic acid |
SK279918B6 (sk) * | 1993-03-26 | 1999-05-07 | Gist-Brocades N.V. | Soli kyseliny klavulánovej s diamínmi, spôsob ich |
EP0937084A1 (en) * | 1996-11-11 | 1999-08-25 | Gist-Brocades B.V. | Process for the preparation of salts and esters of clavulanic acid |
AU1234999A (en) * | 1997-11-10 | 1999-05-31 | Gist-Brocades B.V. | Crystallization of beta-lactam compounds |
-
1999
- 1999-07-13 CA CA002337072A patent/CA2337072A1/en not_active Abandoned
- 1999-07-13 EP EP99940010A patent/EP1095046A1/en not_active Withdrawn
- 1999-07-13 WO PCT/EP1999/005026 patent/WO2000004028A1/en not_active Application Discontinuation
- 1999-07-13 TR TR2001/00082T patent/TR200100082T2/tr unknown
- 1999-07-13 AU AU54110/99A patent/AU5411099A/en not_active Abandoned
- 1999-07-13 CN CN 99809491 patent/CN1312814A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
CN1312814A (zh) | 2001-09-12 |
CA2337072A1 (en) | 2000-01-27 |
EP1095046A1 (en) | 2001-05-02 |
WO2000004028A1 (en) | 2000-01-27 |
AU5411099A (en) | 2000-02-07 |
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