NO970581L - Fremgangsmåte for fremstilling av 4-oksoimidazoliniumsalter - Google Patents

Fremgangsmåte for fremstilling av 4-oksoimidazoliniumsalter

Info

Publication number
NO970581L
NO970581L NO970581A NO970581A NO970581L NO 970581 L NO970581 L NO 970581L NO 970581 A NO970581 A NO 970581A NO 970581 A NO970581 A NO 970581A NO 970581 L NO970581 L NO 970581L
Authority
NO
Norway
Prior art keywords
rog
preparation
strong acid
oxoimidazolinium
salts
Prior art date
Application number
NO970581A
Other languages
English (en)
Other versions
NO970581D0 (no
NO306674B1 (no
Inventor
Barry Jackson
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag filed Critical Lonza Ag
Publication of NO970581D0 publication Critical patent/NO970581D0/no
Publication of NO970581L publication Critical patent/NO970581L/no
Publication of NO306674B1 publication Critical patent/NO306674B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/29—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups and acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C07C255/44—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms at least one of the singly-bound nitrogen atoms being acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

4-Oksoimidazoliniumsalte: med den generelle forme!. hvori Rog Renten uavhengig av hverandre betyr C_-aikyl, C-io-alkenyl, C.i_7-cyk!oalk>'l eller eventuelt substituiert aryl, arylalkyl, heteroary! eller heteroarylalkyl, eller Rog Rsammen med karbonatomet som forbinder dem danner en tre- til syv-leddet mettet eller umettet karbocyklisk eller heterocyklisk ring, Ren C-alkylgruppe, C--alkenylgruppe, C--cykloalkylgruppe, arylgruppe, arylalkylgruppe eller heteroarylgruppe og A" er et anion av en sterk syre, fremstilles ved cyklisering av et a-acylamino-nitril i et ikke-vandig løsningsmiddel i nærvær en lavere alkohol og en sterk syre. Forbindelseene er mellomprodukter for farmasøytiske virkestoffer som for eksempel Angiotensin II-antagonister.
NO970581A 1996-02-09 1997-02-07 FremgangsmÕte for fremstilling av 4-oksoimidazoliniumsalter NO306674B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH33296 1996-02-09

Publications (3)

Publication Number Publication Date
NO970581D0 NO970581D0 (no) 1997-02-07
NO970581L true NO970581L (no) 1997-08-11
NO306674B1 NO306674B1 (no) 1999-12-06

Family

ID=4184613

Family Applications (1)

Application Number Title Priority Date Filing Date
NO970581A NO306674B1 (no) 1996-02-09 1997-02-07 FremgangsmÕte for fremstilling av 4-oksoimidazoliniumsalter

Country Status (18)

Country Link
US (1) US5698704A (no)
EP (1) EP0789019B1 (no)
JP (1) JP4224629B2 (no)
KR (1) KR100490220B1 (no)
CN (1) CN1071747C (no)
AT (1) ATE202090T1 (no)
CA (1) CA2196263C (no)
CZ (1) CZ291500B6 (no)
DE (1) DE59703745D1 (no)
DK (1) DK0789019T3 (no)
ES (1) ES2158385T3 (no)
GR (1) GR3036558T3 (no)
HU (1) HU225694B1 (no)
NO (1) NO306674B1 (no)
PL (1) PL191419B1 (no)
PT (1) PT789019E (no)
SK (1) SK282845B6 (no)
TW (1) TW407152B (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU218681B (hu) * 1997-07-25 2000-10-30 Sanofi-Synthelabo Eljárás 1,3-diaza-spiro(4,4)non-1-én-4-on-származékok előállitására és 1-ciano-1-(acil-amino)-ciklopentán intermedierek
HU218680B (hu) * 1997-07-25 2000-10-30 Sanofi-Synthelabo Eljárás 1,3-diaza-spiro[4,4]non-1-én-4-on-származékok előállítására és 1-ciano-1-(acil-amino)-ciklopentán intermedierek
JP2002507611A (ja) * 1998-03-25 2002-03-12 ブリストル−マイヤーズ スクイブ カンパニー イミダゾロン食欲抑制薬：ｉｉ．フェニル誘導体
EP0945441A3 (de) * 1998-03-27 2002-07-17 Degussa AG Verfahren zur Herstellung von cyclischen 4-Oxoamidinen
US5910595A (en) * 1998-06-26 1999-06-08 Salsbury Chemicals, Inc. Process for preparing oximidazoles
JP4505329B2 (ja) * 2002-09-04 2010-07-21 メルク フロスト カナダ リミテツド カテプシンシステインプロテアーゼ阻害薬
US9126998B2 (en) 2012-11-05 2015-09-08 Bayer Pharma AG Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use
US9624214B2 (en) 2012-11-05 2017-04-18 Bayer Pharma Aktiengesellschaft Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use
US8796305B2 (en) 2012-11-05 2014-08-05 Bayer Pharma Aktiengesellschaft Carboxy-substituted imidazo[1,2-a]pyridinecarboxamides and their use
US8778964B2 (en) 2012-11-05 2014-07-15 Bayer Pharma Aktiengesellschaft Hydroxy-substituted imidazo[1,2-a]-pyridinecarboxamides and their use
CA2914100A1 (en) 2013-06-04 2014-12-11 Bayer Pharma Aktiengesellschaft 3-aryl-substituted imidazo[1,2-a]pyridines and the use thereof
US9422285B2 (en) 2013-08-08 2016-08-23 Bayer Pharma Aktiengesellschaft Substituted pyrazolo[1,5-A]-pyridine-3-carboxamides and use thereof
CA2939793A1 (en) 2014-02-19 2015-08-27 Bayer Pharma Aktiengesellschaft 3-(pyrimidine-2-yl)imidazo[1,2-a]pyridines
US9771360B2 (en) 2014-03-21 2017-09-26 Bayer Pharma Aktiengesellschaft Cyano-substituted imidazo[1,2-A]pyridinecarboxamides and their use
CA2969265A1 (en) 2014-12-02 2016-06-09 Bayer Pharma Aktiengesellschaft Substituted pyrazolo[1,5-a]pyridines and imidazo[1,2-a]pyrazines and their use
CA2969268A1 (en) 2014-12-02 2016-06-09 Bayer Pharma Aktiengesellschaft Heteroaryl-substituted imidazo[1,2-a]pyridines and their use
CN107567446A (zh) 2015-02-05 2018-01-09 拜耳制药股份公司 取代的吡唑并[1,5‑a]吡啶‑3‑甲酰胺及其用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4709036A (en) * 1985-06-13 1987-11-24 American Cyanamid Company Process for the preparation of herbicidal 2-(4,4-disubstituted-5-oxo-2-imidazolin-2-yl)benzoic, nicotinic and quinoline-3-carboxylic acids, esters and salts
IE910913A1 (en) * 1990-03-20 1991-09-25 Sanofi Sa N-substituted heterocyclic derivates, their preparation¹and pharmaceutical compositions containing them
JPH06510762A (ja) * 1991-08-19 1994-12-01 イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー アンジオテンシン２受容体遮断イミダゾリノン誘導体

Also Published As

Publication number Publication date
HU9700380D0 (en) 1997-03-28
JP4224629B2 (ja) 2009-02-18
PL191419B1 (pl) 2006-05-31
HUP9700380A3 (en) 1998-04-28
PT789019E (pt) 2001-11-30
HUP9700380A2 (en) 1997-10-28
PL318370A1 (en) 1997-08-18
CZ291500B6 (cs) 2003-03-12
NO970581D0 (no) 1997-02-07
CA2196263C (en) 2004-10-26
KR970061874A (ko) 1997-09-12
HU225694B1 (en) 2007-06-28
NO306674B1 (no) 1999-12-06
DE59703745D1 (de) 2001-07-19
EP0789019A1 (de) 1997-08-13
TW407152B (en) 2000-10-01
JPH09227527A (ja) 1997-09-02
SK282845B6 (sk) 2002-12-03
DK0789019T3 (da) 2001-09-03
CN1071747C (zh) 2001-09-26
ATE202090T1 (de) 2001-06-15
US5698704A (en) 1997-12-16
CZ38697A3 (en) 1997-08-13
GR3036558T3 (en) 2001-12-31
KR100490220B1 (ko) 2005-09-08
CN1162595A (zh) 1997-10-22
SK16097A3 (en) 1997-09-10
ES2158385T3 (es) 2001-09-01
EP0789019B1 (de) 2001-06-13
CA2196263A1 (en) 1997-08-10

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