AU2008220785B2 - New use of glutaminyl cyclase inhibitors - Google Patents
New use of glutaminyl cyclase inhibitors Download PDFInfo
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- AU2008220785B2 AU2008220785B2 AU2008220785A AU2008220785A AU2008220785B2 AU 2008220785 B2 AU2008220785 B2 AU 2008220785B2 AU 2008220785 A AU2008220785 A AU 2008220785A AU 2008220785 A AU2008220785 A AU 2008220785A AU 2008220785 B2 AU2008220785 B2 AU 2008220785B2
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- methyl
- dimethoxy
- methoxy
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
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- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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Applications Claiming Priority (5)
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| US89226507P | 2007-03-01 | 2007-03-01 | |
| US60/892,265 | 2007-03-01 | ||
| US11/685,881 | 2007-03-14 | ||
| US11/685,881 US7732162B2 (en) | 2003-05-05 | 2007-03-14 | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| PCT/EP2008/052411 WO2008104580A1 (en) | 2007-03-01 | 2008-02-28 | New use of glutaminyl cyclase inhibitors |
Publications (2)
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| AU2008220785A1 AU2008220785A1 (en) | 2008-09-04 |
| AU2008220785B2 true AU2008220785B2 (en) | 2013-02-21 |
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| AU2008220785A Active AU2008220785B2 (en) | 2007-03-01 | 2008-02-28 | New use of glutaminyl cyclase inhibitors |
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| CN (1) | CN101668525A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008220785B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2679446C (cg-RX-API-DMAC7.html) |
| EA (1) | EA200901140A1 (cg-RX-API-DMAC7.html) |
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| MX (1) | MX2009009234A (cg-RX-API-DMAC7.html) |
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| WO (1) | WO2008104580A1 (cg-RX-API-DMAC7.html) |
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| US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
| JP5203360B2 (ja) | 2006-06-23 | 2013-06-05 | アボット・ラボラトリーズ | ヒスタミンｈ３受容体調節剤としてのシクロプロピルアミン誘導体 |
| KR20140133897A (ko) * | 2007-03-01 | 2014-11-20 | 프로비오드룩 아게 | 글루타미닐 사이클라제 저해제의 신규 용도 |
| US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
| UA108742C2 (uk) * | 2009-09-23 | 2015-06-10 | Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1 | |
| JP2013519891A (ja) * | 2010-02-18 | 2013-05-30 | プロビオドルグ エージー | ピログルタミン酸修飾ｍｃｐ−１を決定することにより炎症性疾患を診断する方法及びグルタミニルシクラーゼの阻害剤のスクリーニング方法 |
| WO2012037258A1 (en) | 2010-09-16 | 2012-03-22 | Abbott Laboratories | Processes for preparing 1,2-substituted cyclopropyl derivatives |
| CN105384691B (zh) * | 2015-10-26 | 2018-06-29 | 深圳大学 | 一种谷氨酰胺酰基环化酶抑制剂的制备方法及应用 |
| CN105384692B (zh) * | 2015-10-26 | 2018-06-29 | 深圳大学 | 一种谷氨酰胺酰基环化酶抑制剂 |
| EP3747438A1 (en) * | 2017-07-24 | 2020-12-09 | Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis | Treating pathological conditions by direct and indirect targeting of sirpa - cd47 interaction |
| KR102230832B1 (ko) * | 2019-06-17 | 2021-03-24 | (주) 메디프론디비티 | N-치환된 티오우레아 또는 우레아 유도체 및 이를 유효성분으로 함유하는 글루타미닐 사이클레이즈 활성 관련 질환의 예방 또는 치료용 약학적 조성물 |
| CN118019737A (zh) | 2021-06-24 | 2024-05-10 | 英矽智能科技知识产权有限公司 | 用于治疗疾病的β-内酰胺衍生物 |
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- 2008-02-28 AU AU2008220785A patent/AU2008220785B2/en active Active
- 2008-02-28 KR KR1020097018475A patent/KR20090115951A/ko not_active Ceased
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- 2008-02-28 EP EP11192085A patent/EP2481408A3/en not_active Withdrawn
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| WO2004098591A2 (en) * | 2003-05-05 | 2004-11-18 | Probiodrug Ag | Inhibitors of glutaminyl cyclase and their use in the treatment of neurological diseases |
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| NZ579310A (en) | 2012-03-30 |
| CA2679446C (en) | 2016-05-17 |
| IL200315A0 (en) | 2010-04-29 |
| WO2008104580A1 (en) | 2008-09-04 |
| MX2009009234A (es) | 2009-12-01 |
| JP2010520168A (ja) | 2010-06-10 |
| ZA200905537B (en) | 2010-10-27 |
| EP2117540A1 (en) | 2009-11-18 |
| IL200315A (en) | 2017-08-31 |
| KR20090115951A (ko) | 2009-11-10 |
| CA2679446A1 (en) | 2008-09-04 |
| JP5930573B2 (ja) | 2016-06-15 |
| EA200901140A1 (ru) | 2010-04-30 |
| CN101668525A (zh) | 2010-03-10 |
| AU2008220785A1 (en) | 2008-09-04 |
| EP2481408A2 (en) | 2012-08-01 |
| EP2481408A3 (en) | 2013-01-09 |
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