ATE553758T1 - Hemmer für die produktion und freisetzung entzündlicher zytokine - Google Patents

Hemmer für die produktion und freisetzung entzündlicher zytokine

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Publication number
ATE553758T1
ATE553758T1 AT07015076T AT07015076T ATE553758T1 AT E553758 T1 ATE553758 T1 AT E553758T1 AT 07015076 T AT07015076 T AT 07015076T AT 07015076 T AT07015076 T AT 07015076T AT E553758 T1 ATE553758 T1 AT E553758T1
Authority
AT
Austria
Prior art keywords
inhibitors
release
production
inflammatory cytokine
group
Prior art date
Application number
AT07015076T
Other languages
English (en)
Inventor
Susumu Muto
Tatsuo Nagano
Tomomi Saotome
Akiko Itai
Original Assignee
Inst Med Molecular Design Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Med Molecular Design Inc filed Critical Inst Med Molecular Design Inc
Application granted granted Critical
Publication of ATE553758T1 publication Critical patent/ATE553758T1/de

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A61K31/055—Phenols the aromatic ring being substituted by halogen
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
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    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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JP4217981B2 (ja) 2005-02-08 2009-02-04 Ｓｍｃ株式会社 直動・回転複合アクチュエータ
JP4217916B2 (ja) 2006-02-15 2009-02-04 三菱ふそうトラック・バス株式会社 ハイブリッド電気自動車の制御装置

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CN1489458A (zh) 2004-04-14
EP1844766B1 (de) 2012-04-18
US20080249071A1 (en) 2008-10-09
EA011719B1 (ru) 2009-04-28
UA82827C2 (en) 2008-05-26
US20100274051A1 (en) 2010-10-28
HK1063433A1 (en) 2004-12-31
US20040259877A1 (en) 2004-12-23
CA2431083C (en) 2011-08-09
JP4224566B2 (ja) 2009-02-18
EP1847263A3 (de) 2009-08-26
CA2431083A1 (en) 2002-06-27
EP1847263A2 (de) 2007-10-24
CN101849953B (zh) 2012-04-25
CN100370975C (zh) 2008-02-27
AU2002222683B2 (en) 2006-09-21
EP1352650A1 (de) 2003-10-15
AU2268302A (en) 2002-07-01
AU2002222683B9 (en) 2021-12-23
EP1844766A3 (de) 2009-04-29
WO2002049632A1 (fr) 2002-06-27
KR20030070063A (ko) 2003-08-27
US8263657B2 (en) 2012-09-11
US20090192122A2 (en) 2009-07-30
EP1844766A2 (de) 2007-10-17
US8097759B2 (en) 2012-01-17
US20080318956A1 (en) 2008-12-25
JPWO2002049632A1 (ja) 2004-04-15
EP1352650B1 (de) 2012-03-07
EA200300695A1 (ru) 2003-12-25
ATE548031T1 (de) 2012-03-15
EP1352650A4 (de) 2005-07-20
CN101849953A (zh) 2010-10-06
KR101088557B1 (ko) 2011-12-05
KR20090090406A (ko) 2009-08-25

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