ATE352631T1 - Heterologe expression von neisseria proteine - Google Patents
Heterologe expression von neisseria proteineInfo
- Publication number
- ATE352631T1 ATE352631T1 AT01914109T AT01914109T ATE352631T1 AT E352631 T1 ATE352631 T1 AT E352631T1 AT 01914109 T AT01914109 T AT 01914109T AT 01914109 T AT01914109 T AT 01914109T AT E352631 T1 ATE352631 T1 AT E352631T1
- Authority
- AT
- Austria
- Prior art keywords
- expression
- heterologue
- proteins
- neisseria
- neisseria proteins
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 241000588653 Neisseria Species 0.000 title 1
- 241000588652 Neisseria gonorrhoeae Species 0.000 abstract 1
- 241000588650 Neisseria meningitidis Species 0.000 abstract 1
- 230000030570 cellular localization Effects 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0004695A GB0004695D0 (en) | 2000-02-28 | 2000-02-28 | Protein expression |
| GB0027675A GB0027675D0 (en) | 2000-11-13 | 2000-11-13 | Protein Expression |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE352631T1 true ATE352631T1 (de) | 2007-02-15 |
Family
ID=26243750
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08075111T ATE503837T1 (de) | 2000-02-28 | 2001-02-28 | Hybride expression neisserscher proteine |
| AT01914109T ATE352631T1 (de) | 2000-02-28 | 2001-02-28 | Heterologe expression von neisseria proteine |
| AT01914098T ATE387502T1 (de) | 2000-02-28 | 2001-02-28 | Hybride expression von neisseria proteinen |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08075111T ATE503837T1 (de) | 2000-02-28 | 2001-02-28 | Hybride expression neisserscher proteine |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01914098T ATE387502T1 (de) | 2000-02-28 | 2001-02-28 | Hybride expression von neisseria proteinen |
Country Status (19)
| Country | Link |
|---|---|
| US (9) | US20040092711A1 (OSRAM) |
| EP (6) | EP2270030B1 (OSRAM) |
| JP (8) | JP4846160B2 (OSRAM) |
| CN (7) | CN1201011C (OSRAM) |
| AT (3) | ATE503837T1 (OSRAM) |
| AU (4) | AU2001239478B2 (OSRAM) |
| BR (2) | BR0108711A (OSRAM) |
| CA (5) | CA2400562C (OSRAM) |
| CY (6) | CY1106532T1 (OSRAM) |
| DE (3) | DE60126249T2 (OSRAM) |
| DK (4) | DK1790660T3 (OSRAM) |
| ES (5) | ES2391153T3 (OSRAM) |
| LU (1) | LU92240I2 (OSRAM) |
| MX (2) | MXPA02008314A (OSRAM) |
| NL (1) | NL300605I2 (OSRAM) |
| NZ (2) | NZ521396A (OSRAM) |
| PT (4) | PT1261723E (OSRAM) |
| RU (2) | RU2299906C2 (OSRAM) |
| WO (2) | WO2001064922A2 (OSRAM) |
Families Citing this family (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998012332A1 (en) | 1996-09-17 | 1998-03-26 | Chiron Corporation | Compositions and methods for treating intracellular diseases |
| DK1047784T4 (en) * | 1998-01-14 | 2015-06-15 | Novartis Vaccines & Diagnostic | NEISSERA meningitidis ANTIGENS |
| MX343752B (es) | 1998-05-01 | 2016-11-22 | Novartis Vaccines & Diagnostics Inc | Antigenos de neisseria meningitidis y composiciones que los contienen. |
| US20070026021A1 (en) * | 1998-05-01 | 2007-02-01 | Chiron S.R.I. | Neisseria meningitidis antigens and compositions |
| JP4812942B2 (ja) * | 1999-02-26 | 2011-11-09 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル | CGモチーフを含むオリゴヌクレオチドを用いるNeisseria抗原殺菌活性の増強 |
| JP2003518363A (ja) | 1999-04-30 | 2003-06-10 | カイロン エセ.ピー.アー. | 保存されたナイセリア抗原 |
| GB9911683D0 (en) * | 1999-05-19 | 1999-07-21 | Chiron Spa | Antigenic peptides |
| WO2000071725A2 (en) | 1999-05-19 | 2000-11-30 | Chiron S.P.A. | Combination neisserial compositions |
| PT2275551E (pt) | 1999-10-29 | 2015-06-29 | Novartis Vaccines & Diagnostic | Péptidos antigénicos de neisseria |
| GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
| NZ520466A (en) * | 2000-01-17 | 2003-09-26 | Chiron S | Outer membrane vesicle (OMV) vaccine comprising n. meningitidis serogroup B outer membrane proteins |
| ATE503837T1 (de) * | 2000-02-28 | 2011-04-15 | Novartis Vaccines & Diagnostic | Hybride expression neisserscher proteine |
| JP2004529643A (ja) * | 2001-04-17 | 2004-09-30 | カイロン コーポレイション | 機能活性抗体を誘発する髄膜炎菌性bエピトープの分子模倣物 |
| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| US6928463B1 (en) * | 2001-07-06 | 2005-08-09 | Nortel Networks Limited | Broadband content delivery via personal content tunnel |
| GB0118249D0 (en) | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
| CA2452836C (en) * | 2001-07-27 | 2012-11-27 | Chiron Srl | Meningococcus adhesins nada, app and orf 40 |
| GB0121591D0 (en) * | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
| AU2014201962B2 (en) * | 2001-09-06 | 2016-06-09 | Glaxosmithkline Vaccines S.R.L. | Hybrid and tandem expression of Neisserial proteins |
| CA2462646C (en) * | 2001-10-03 | 2013-02-12 | Chiron Corporation | Adjuvanted meningococcus compositions |
| AR045702A1 (es) | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
| US7838015B2 (en) | 2001-10-03 | 2010-11-23 | Novartis Vaccines And Diagnostics, Inc. | Adjuvanted meningococcus compositions |
| MX339524B (es) * | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| DE20321889U1 (de) | 2002-08-02 | 2012-03-12 | Glaxosmithkline Biologicals S.A. | Impfstoffzusammensetzung |
| US7785608B2 (en) | 2002-08-30 | 2010-08-31 | Wyeth Holdings Corporation | Immunogenic compositions for the prevention and treatment of meningococcal disease |
| ATE492288T1 (de) | 2002-10-11 | 2011-01-15 | Novartis Vaccines & Diagnostic | Polypeptidimpstoffe zum breiten schutz gegen hypervirulente meningokokken-linien |
| ATE352316T1 (de) | 2002-11-01 | 2007-02-15 | Glaxosmithkline Biolog Sa | Immunogene zusammensetzung |
| ATE466875T1 (de) | 2002-11-15 | 2010-05-15 | Novartis Vaccines & Diagnostic | Unerwartete oberflächenproteine in neisseria meningitidis |
| GB0227346D0 (en) * | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| CN102302776B (zh) * | 2003-01-30 | 2014-06-18 | 诺华疫苗和诊断有限公司 | 抗多种脑膜炎球菌血清组的可注射性疫苗 |
| ATE516306T1 (de) | 2003-08-13 | 2011-07-15 | Novartis Vaccines & Diagnostic | Verbessertes verfahren zur reinigung von tfpi und tfpi-analogen |
| GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
| CN103405761A (zh) | 2003-10-02 | 2013-11-27 | 诺华疫苗和诊断有限公司 | 多种脑膜炎球菌血清群的液体疫苗 |
| GB0408977D0 (en) | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
| GB0409748D0 (en) | 2004-04-30 | 2004-06-09 | Chiron Srl | Lactoferrin cleavage |
| GB0419408D0 (en) * | 2004-09-01 | 2004-10-06 | Chiron Srl | 741 chimeric polypeptides |
| GB0424092D0 (en) | 2004-10-29 | 2004-12-01 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
| PL2351772T3 (pl) | 2005-02-18 | 2017-01-31 | Glaxosmithkline Biologicals Sa | Białka i kwasy nukleinowe z bakterii Escherichia coli związanej z zapaleniem opon mózgowo-rdzeniowych/posocznicą |
| NZ560929A (en) | 2005-02-18 | 2009-12-24 | Novartis Vaccines & Diagnostic | Immunogens from uropathogenic escherichia coli |
| CN100475965C (zh) * | 2005-07-22 | 2009-04-08 | 上海高科联合生物技术研发有限公司 | 一种大肠杆菌高效外分泌表达溶葡萄球菌酶的方法 |
| GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
| EP1962902A2 (en) * | 2005-12-06 | 2008-09-03 | Universita Degli Studi di Padova | Methods and compositions relating to adhesins as adjuvants |
| US20100166788A1 (en) | 2006-08-16 | 2010-07-01 | Novartis Vaccines And Diagnostics | Immunogens from uropathogenic escherichia coli |
| AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
| GB0700562D0 (en) | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
| GB0713880D0 (en) | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
| ATE553774T1 (de) | 2007-10-19 | 2012-05-15 | Novartis Ag | Meningokokkenimpfstoffformulierungen |
| US9579372B2 (en) | 2008-02-21 | 2017-02-28 | Glaxosmithkline Biologicals Sa | Meningococcal fHBP polypeptides |
| KR101208778B1 (ko) | 2008-03-03 | 2012-12-05 | 노파르티스 아게 | Tlr 활성 조정제로서의 화합물 및 조성물 |
| RU2360926C9 (ru) * | 2008-03-17 | 2009-09-10 | Всеволод Иванович Киселев | ГИБРИДНЫЙ БЕЛОК CFP10-ESAT6, ИНДУЦИРУЮЩИЙ РЕАКЦИЮ ГИПЕРЧУВСТВИТЕЛЬНОСТИ ЗАМЕДЛЕННОГО ТИПА В ОТНОШЕНИИ M.Tuberculosis, КОДИРУЮЩАЯ ЕГО ХИМЕРНАЯ НУКЛЕИНОВАЯ КИСЛОТА И РЕКОМБИНАНТНЫЙ ПЛАЗМИДНЫЙ ЭКСПРЕССИРУЮЩИЙ ВЕКТОР, ЕЕ СОДЕРЖАЩИЙ, СПОСОБ ПОЛУЧЕНИЯ ГИБРИДНОГО БЕЛКА И ДОЗИРОВАННАЯ ЛЕКАРСТВЕННАЯ ФОРМА ДЛЯ ВНУТРИКОЖНОЙ ИНЪЕКЦИИ НА ЕГО ОСНОВЕ |
| WO2009150531A1 (en) * | 2008-06-09 | 2009-12-17 | Novartis Ag | Antibodies against neisserial factor h binding protein |
| JP5487463B2 (ja) * | 2008-08-08 | 2014-05-07 | 独立行政法人産業技術総合研究所 | 非拡散植物ウイルスベクター |
| HRP20201076T1 (hr) | 2009-03-24 | 2020-10-30 | Glaxosmithkline Biologicals Sa | Adjuvantni vezujući protein meningokokalnog faktora h |
| WO2010144734A1 (en) | 2009-06-10 | 2010-12-16 | Novartis Ag | Benzonaphthyridine-containing vaccines |
| EP2443250B8 (en) | 2009-06-16 | 2016-09-21 | GlaxoSmithKline Biologicals SA | High-throughput complement-mediated antibody-dependent and opsonic bactericidal assays |
| NZ622048A (en) | 2009-08-27 | 2015-10-30 | Novartis Ag | Hybrid polypeptides including meningococcal fhbp sequences |
| JO3257B1 (ar) | 2009-09-02 | 2018-09-16 | Novartis Ag | مركبات وتركيبات كمعدلات لفاعلية tlr |
| CN102844047B (zh) | 2009-09-02 | 2017-04-05 | 诺华股份有限公司 | 含tlr活性调节剂的免疫原性组合物 |
| CN102724988B (zh) | 2009-09-30 | 2014-09-10 | 诺华股份有限公司 | 脑膜炎球菌fHBP多肽的表达 |
| AU2010310985B2 (en) | 2009-10-27 | 2014-11-06 | Glaxosmithkline Biologicals S.A. | Modified meningococcal fHBP polypeptides |
| WO2011057148A1 (en) | 2009-11-05 | 2011-05-12 | Irm Llc | Compounds and compositions as tlr-7 activity modulators |
| CN102762206A (zh) | 2009-12-15 | 2012-10-31 | 诺华有限公司 | 免疫增强化合物的均匀悬液及其用途 |
| CA2792938C (en) | 2010-03-23 | 2018-07-31 | Irm Llc | Compounds (cystein based lipopeptides) and compositions as tlr2 agonists used for treating infections, inflammations, respiratory diseases etc. |
| US10478483B2 (en) | 2010-06-25 | 2019-11-19 | Glaxosmithkline Biologicals Sa | Combinations of meningococcal factor H binding proteins |
| FI2608805T4 (fi) | 2010-08-23 | 2025-08-07 | Wyeth Llc | NEISSERIA MENINGITIDIS rLP2086 -ANTIGEENIEN STABIILEJA FORMULAATIOITA |
| US9259462B2 (en) | 2010-09-10 | 2016-02-16 | Glaxosmithkline Biologicals Sa | Developments in meningococcal outer membrane vesicles |
| CA2809758C (en) | 2010-09-10 | 2021-07-13 | Wyeth Llc | Non-lipidated variants of neisseria meningitidis orf2086 antigens |
| GB201102090D0 (en) * | 2011-02-08 | 2011-03-23 | Univ Sheffield | Antigenic polypeptide |
| EP2750702A4 (en) | 2011-08-31 | 2015-03-04 | Childrens Hosp & Res Ct Oak | MANIPULATED SEQUENCES FOR THE EXPRESSION OF ANTIGENS IN NEISSERIA AND METHOD OF USE THEREOF |
| MX351993B (es) | 2012-03-09 | 2017-11-03 | Pfizer | Composiciones de neisseria meningitidis y metodos de las mismas. |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| CN104602704B (zh) | 2012-06-14 | 2019-08-06 | 诺华股份有限公司 | 针对血清组x脑膜炎球菌的疫苗 |
| AU2013295242C1 (en) | 2012-07-27 | 2018-08-09 | Institut National De La Sante Et De La Recherche Medicale | CD147 as receptor for pilus-mediated adhesion of meningococci to vascular endothelia |
| WO2014084432A1 (ko) * | 2012-11-30 | 2014-06-05 | 경상대학교 산학협력단 | 헬리코박터 파일로리 발현 벡터 |
| ES2685894T3 (es) | 2013-03-08 | 2018-10-15 | Pfizer Inc. | Polipéptidos de fusión inmunogénicos |
| MX380129B (es) | 2013-09-08 | 2025-03-11 | Pfizer | Composiciones de neisseria meningitidis y sus metodos |
| SG10201907875TA (en) | 2014-02-28 | 2019-09-27 | Glaxosmithkline Biologicals Sa | Modified meningococcal fhbp polypeptides |
| ES2922554T3 (es) | 2014-07-23 | 2022-09-16 | Childrens Hospital & Res Center At Oakland | Variantes de proteínas de unión al factor H y métodos de uso de las mismas |
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| GB201522153D0 (en) | 2015-12-15 | 2016-01-27 | Univ Southampton | Meningococcal infection and modified neisseria lactamica |
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