AU2001276619A1 - Immunisation against chlamydia pneumoniae - Google Patents

Immunisation against chlamydia pneumoniae

Info

Publication number
AU2001276619A1
AU2001276619A1 AU2001276619A AU7661901A AU2001276619A1 AU 2001276619 A1 AU2001276619 A1 AU 2001276619A1 AU 2001276619 A AU2001276619 A AU 2001276619A AU 7661901 A AU7661901 A AU 7661901A AU 2001276619 A1 AU2001276619 A1 AU 2001276619A1
Authority
AU
Australia
Prior art keywords
chlamydia pneumoniae
against chlamydia
immunisation against
immunisation
pneumoniae
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001276619A
Inventor
Guido Grandi
Giulio Ratti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GSK Vaccines SRL
Original Assignee
Chiron SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0016363A external-priority patent/GB0016363D0/en
Priority claimed from GB0017047A external-priority patent/GB0017047D0/en
Priority claimed from GB0017983A external-priority patent/GB0017983D0/en
Priority claimed from GB0019368A external-priority patent/GB0019368D0/en
Priority claimed from GB0020440A external-priority patent/GB0020440D0/en
Priority claimed from GB0022583A external-priority patent/GB0022583D0/en
Priority claimed from GB0027549A external-priority patent/GB0027549D0/en
Priority claimed from GB0031706A external-priority patent/GB0031706D0/en
Application filed by Chiron SRL filed Critical Chiron SRL
Publication of AU2001276619A1 publication Critical patent/AU2001276619A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/295Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Chlamydiales (O)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The published genomic of Chlamydia pneumoniae reveals over 1000 putative encoded proteins but does not itself indicate which of these might to useful antigens for immunisation and vaccination or for diagnosis. This difficulty is addressed by the invention, which provides a number of C . pneumoniae protein sequences suitable for vaccine production and development and/or for diagnostic purposes.
AU2001276619A 2000-07-03 2001-07-03 Immunisation against chlamydia pneumoniae Abandoned AU2001276619A1 (en)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
GB0016363 2000-07-03
GB0016363A GB0016363D0 (en) 2000-07-03 2000-07-03 Immunisation against chlamydia pneumoniae
GB0017047A GB0017047D0 (en) 2000-07-11 2000-07-11 Immunisation against chlamydia pneumoniae
GB0017047 2000-07-11
GB0017983A GB0017983D0 (en) 2000-07-21 2000-07-21 Immunisation against chlamydia pneumoniae
GB0017983 2000-07-21
GB0019368A GB0019368D0 (en) 2000-08-07 2000-08-07 Immunisation against chlamydia pneumoniae
GB0019368 2000-08-07
GB0020440A GB0020440D0 (en) 2000-08-18 2000-08-18 Immunisation against chlamydia pneumoniae
GB0020440 2000-08-18
GB0022583 2000-09-14
GB0022583A GB0022583D0 (en) 2000-09-14 2000-09-14 Immunisation against chlamydia pneumoniae
GB0027549A GB0027549D0 (en) 2000-11-10 2000-11-10 Immunisation against chlamydia pneumoniae
GB0027549 2000-11-10
GB0031706 2000-12-22
GB0031706A GB0031706D0 (en) 2000-12-22 2000-12-22 Immunisation against chlamydia pneumoniae
PCT/IB2001/001445 WO2002002606A2 (en) 2000-07-03 2001-07-03 Immunisation against chlamydia pneumoniae

Publications (1)

Publication Number Publication Date
AU2001276619A1 true AU2001276619A1 (en) 2002-01-14

Family

ID=27571146

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001276619A Abandoned AU2001276619A1 (en) 2000-07-03 2001-07-03 Immunisation against chlamydia pneumoniae

Country Status (8)

Country Link
US (4) US20040005667A1 (en)
EP (2) EP1297005B1 (en)
JP (2) JP2004502415A (en)
AT (1) ATE440861T1 (en)
AU (1) AU2001276619A1 (en)
CA (1) CA2414884A1 (en)
DE (1) DE60139690D1 (en)
WO (1) WO2002002606A2 (en)

Families Citing this family (147)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7141244B1 (en) * 1992-03-02 2006-11-28 Chiron Srl Helicobacter pylori proteins useful for vaccines and diagnostics
ATE229978T1 (en) * 1994-07-01 2003-01-15 Chiron Corp HELICOBACTER PROTEINS AND VACCINES
ES2283012T3 (en) * 1996-01-04 2007-10-16 Novartis Vaccines And Diagnostics, Inc. HELICOBACTER PYLORI BACTERIOFERRITINE.
CA2340283A1 (en) 1998-08-20 2000-03-02 Aventis Pasteur Limited Nucleic acid molecules encoding pomp91a protein of chlamydia
US6686339B1 (en) 1998-08-20 2004-02-03 Aventis Pasteur Limited Nucleic acid molecules encoding inclusion membrane protein C of Chlamydia
EP1105490A1 (en) 1998-08-20 2001-06-13 Aventis Pasteur Limited Nucleic acid molecules encoding inclusion membrane protein c of chlamydia
US6649370B1 (en) 1998-10-28 2003-11-18 Aventis Pasteur Limited Chlamydia antigens and corresponding DNA fragments and uses thereof
US6607730B1 (en) 1998-11-02 2003-08-19 Aventis Pasteur Limited/Aventis Pasteur Limitee Chlamydia antigens and corresponding DNA fragments and uses thereof
AU3790900A (en) 1998-12-01 2000-06-19 Aventis Pasteur Limited Chlamydia antigens and corresponding DNA fragments and uses thereof
US20020061848A1 (en) 2000-07-20 2002-05-23 Ajay Bhatia Compounds and methods for treatment and diagnosis of chlamydial infection
IL143531A0 (en) 1998-12-08 2002-04-21 Corixa Corp Polypeptides containing an antigenic portion of a chlamydia antigen, dna sequences encoding said polypeptides and pharmaceutical compositions and vaccines containing the same
GB9828000D0 (en) 1998-12-18 1999-02-10 Chiron Spa Antigens
US7297341B1 (en) 1998-12-23 2007-11-20 Sanofi Pasteur Limited Chlamydia antigens and corresponding DNA fragments and uses thereof
ATE384738T1 (en) 1998-12-28 2008-02-15 Aventis Pasteur CHLAMYDIA ANTIGENS, CORRESPONDING DNA FRAGMENTS AND THEIR USES
US6808713B1 (en) 1998-12-28 2004-10-26 Aventis Pasteur Limited Chlamydia antigens and corresponding DNA fragments and uses thereof
GB9902555D0 (en) 1999-02-05 1999-03-24 Neutec Pharma Plc Medicament
AU775695B2 (en) 1999-03-12 2004-08-12 Aventis Pasteur Limited Chlamydia antigens and corresponding DNA fragments and uses thereof
CA2373021A1 (en) 1999-05-03 2000-11-09 Aventis Pasteur Limited Chlamydia antigens and corresponding dna fragments and uses thereof
JP4667694B2 (en) 1999-09-20 2011-04-13 サノフィ、パストゥール、リミテッド Chlamydia antigen and corresponding DNA fragments and uses thereof
US6632663B1 (en) 1999-09-22 2003-10-14 Aventis Pasteur Limited DNA immunization against chlamydia infection
EP1240331B1 (en) 1999-12-22 2010-04-07 Aventis Pasteur Limited Chlamydia antigens and corresponding dna fragments and uses thereof
PT2270030E (en) 2000-02-28 2012-07-24 Novartis Vaccines & Diagnostic Heterologous expression of neisserial proteins
US20020132994A1 (en) * 2000-04-04 2002-09-19 Murdin Andrew D. Chlamydia antigens and corresponding DNA fragments and uses thereof
US20020071831A1 (en) * 2000-04-04 2002-06-13 Murdin Andrew D. Chlamydia antigens and corresponding DNA fragments and uses thereof
EP1278855B1 (en) 2000-04-21 2008-03-12 Corixa Corporation Compounds and methods for treatment and diagnosis of chlamydial infection
EP1282718B1 (en) 2000-05-08 2006-12-20 Sanofi Pasteur Limited Chlamydia antigens and corresponding dna fragments and uses thereof
EP1297005B1 (en) 2000-07-03 2009-08-26 Novartis Vaccines and Diagnostics S.r.l. Immunisation against chlamydia pneumoniae
GB0024200D0 (en) * 2000-10-03 2000-11-15 Smithkline Beecham Sa Component vaccine
US20030059896A1 (en) * 2000-12-21 2003-03-27 Shire Biochem Inc. Novel chlamydia antigens and corresponding DNA fragments
US7082569B2 (en) 2001-01-17 2006-07-25 Outlooksoft Corporation Systems and methods providing dynamic spreadsheet functionality
GB0107658D0 (en) 2001-03-27 2001-05-16 Chiron Spa Streptococcus pneumoniae
GB0107661D0 (en) 2001-03-27 2001-05-16 Chiron Spa Staphylococcus aureus
EP1604688B1 (en) 2001-06-05 2010-02-03 CureVac GmbH Stabilised tumour-antigen mRNA with increased G/C-content
GB0115176D0 (en) 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
GB0118249D0 (en) 2001-07-26 2001-09-19 Chiron Spa Histidine vaccines
GB0121591D0 (en) 2001-09-06 2001-10-24 Chiron Spa Hybrid and tandem expression of neisserial proteins
EP1423142A1 (en) * 2001-08-31 2004-06-02 Chiron SRL. Helicobacter pylori vaccination with a combination of caga, vaca and nap proteins
ES2312649T3 (en) 2001-12-12 2009-03-01 Novartis Vaccines And Diagnostics S.R.L. IMMUNIZATION AGAINST CHLAMYDIA TRACHOMATIS.
DE10162480A1 (en) 2001-12-19 2003-08-07 Ingmar Hoerr The application of mRNA for use as a therapeutic agent against tumor diseases
AU2003235707A1 (en) * 2002-01-18 2003-07-30 Curevac Gmbh Immunogenic preparations and vaccines on the basis of mrna
GB0203403D0 (en) 2002-02-13 2002-04-03 Chiron Spa Chlamydia cytotoxic-T cell epitopes
GB0220194D0 (en) 2002-08-30 2002-10-09 Chiron Spa Improved vesicles
ES2649048T3 (en) 2002-11-01 2018-01-09 Glaxosmithkline Biologicals S.A. Drying procedure
EP2279746B1 (en) 2002-11-15 2013-10-02 Novartis Vaccines and Diagnostics S.r.l. Surface proteins in neisseria meningitidis
GB0227346D0 (en) 2002-11-22 2002-12-31 Chiron Spa 741
CA2520124A1 (en) 2003-03-28 2004-10-14 Chiron Corporation Use of benzazole compounds for immunopotentiation
GB0308198D0 (en) 2003-04-09 2003-05-14 Chiron Srl ADP-ribosylating bacterial toxin
PL1631264T5 (en) 2003-06-02 2018-09-28 Glaxosmithkline Biologicals Sa Immunogenic compositions based on biodegradable microparticles comprising a diphtheria- and a tetanus toxoid
US7350597B2 (en) * 2003-08-19 2008-04-01 At-Balance Americas Llc Drilling system and method
JP2007511227A (en) * 2003-11-21 2007-05-10 サノフィ パストゥール リミテッド Immunity against Chlamydia infection
WO2005084306A2 (en) * 2004-03-02 2005-09-15 Chiron Corporation Immunogenic compositions for chlamydia pneunomiae
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
EP2612679A1 (en) 2004-07-29 2013-07-10 Novartis Vaccines and Diagnostics, Inc. Immunogenic compositions for gram positive bacteria such as streptococcus agalactiae
DE102004042546A1 (en) * 2004-09-02 2006-03-09 Curevac Gmbh Combination therapy for immune stimulation
GB0424092D0 (en) 2004-10-29 2004-12-01 Chiron Srl Immunogenic bacterial vesicles with outer membrane proteins
GB0502096D0 (en) 2005-02-01 2005-03-09 Chiron Srl Purification of streptococcal capsular polysaccharide
GB0502095D0 (en) 2005-02-01 2005-03-09 Chiron Srl Conjugation of streptococcal capsular saccharides
CN101203529A (en) 2005-02-18 2008-06-18 诺华疫苗和诊断公司 Proteins and nucleic acids from meningitis/sepsis-associated escherichia coli
SI2351772T1 (en) 2005-02-18 2016-11-30 Glaxosmithkline Biologicals Sa Proteins and nucleic acids from meningitis/sepsis-associated Escherichia coli
EP2357000A1 (en) 2005-10-18 2011-08-17 Novartis Vaccines and Diagnostics, Inc. Mucosal and systemic immunizations with alphavirus replicon particles
WO2007081447A2 (en) 2005-11-22 2007-07-19 Novartis Vaccines And Diagnostics, Inc. Norovirus and sapovirus antigens
CA2637598A1 (en) 2006-01-18 2007-02-14 University Of Chicago Compositions and methods related to staphylococcal bacterium proteins
ES2536426T3 (en) 2006-03-23 2015-05-25 Novartis Ag Imidazoquinoxaline compounds as immunomodulators
BRPI0711557A2 (en) * 2006-05-05 2011-11-08 Perkinelmer Las Inc methods for determining an amount of a first analyte in a sample by mass spectroscopy and for screening blood by mass spectroscopy for at least one disorder, and, solid substrate
JP2010500399A (en) 2006-08-16 2010-01-07 ノバルティス アーゲー Immunogen from Urinary Pathogenic Escherichia coli
GB0700562D0 (en) 2007-01-11 2007-02-21 Novartis Vaccines & Diagnostic Modified Saccharides
KR101621837B1 (en) 2007-09-12 2016-05-17 노파르티스 아게 Gas57 mutant antigens and gas57 antibodies
CN104292312A (en) 2007-12-21 2015-01-21 诺华股份有限公司 Mutant forms of streptolysin o
US8466167B2 (en) 2008-03-03 2013-06-18 Irm Llc Compounds and compositions as TLR activity modulators
CN102159242A (en) 2008-09-18 2011-08-17 诺华有限公司 Vaccine adjuvant combinations
ES2586308T3 (en) 2008-10-27 2016-10-13 Glaxosmithkline Biologicals Sa Purification procedure of a group A Streptococcus carbohydrate
US8585505B2 (en) 2008-12-15 2013-11-19 Tetris Online, Inc. Inter-game interactive hybrid asynchronous computer game infrastructure
AU2010203223B9 (en) 2009-01-05 2015-10-08 Epitogenesis Inc. Adjuvant compositions and methods of use
AU2010204139A1 (en) 2009-01-12 2011-08-11 Novartis Ag Cna_B domain antigens in vaccines against gram positive bacteria
US8568732B2 (en) 2009-03-06 2013-10-29 Novartis Ag Chlamydia antigens
ITMI20090946A1 (en) 2009-05-28 2010-11-29 Novartis Ag EXPRESSION OF RECOMBINANT PROTEINS
TR201802380T4 (en) 2009-06-10 2018-03-21 Glaxosmithkline Biologicals Sa Vaccines containing benzonaphthyridine.
ES2596653T3 (en) 2009-06-16 2017-01-11 Glaxosmithkline Biologicals Sa Opsonization bactericidal and antibody-dependent assays mediated by high-performance complement
JP2013503148A (en) 2009-08-27 2013-01-31 ノバルティス アーゲー Adjuvants containing aluminum, oligonucleotides and polycations
TWI445708B (en) 2009-09-02 2014-07-21 Irm Llc Compounds and compositions as tlr activity modulators
AU2010290896B2 (en) 2009-09-02 2014-07-03 Glaxosmithkline Biologicals S.A. Immunogenic compositions including TLR activity modulators
CA2779798C (en) 2009-09-30 2019-03-19 Novartis Ag Conjugation of staphylococcus aureus type 5 and type 8 capsular polysaccharides
JP5914344B2 (en) 2009-10-30 2016-05-11 ノバルティス アーゲー Purification of Staphylococcus aureus type 5 and type 8 capsular saccharides
WO2011057148A1 (en) 2009-11-05 2011-05-12 Irm Llc Compounds and compositions as tlr-7 activity modulators
JP5814933B2 (en) 2009-12-15 2015-11-17 ノバルティス アーゲー Homogeneous suspension of immune enhancing compounds and uses thereof
EP2549990A1 (en) 2010-03-23 2013-01-30 Irm Llc Compounds (cystein based lipopeptides) and compositions as tlr2 agonists used for treating infections, inflammations, respiratory diseases etc.
WO2011133433A2 (en) * 2010-04-16 2011-10-27 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Real time pcr assay for detection of bacterial respiratory pathogens
SI3243526T1 (en) 2010-07-06 2020-02-28 Glaxosmithkline Biologicals S.A. Delivery of rna to trigger multiple immune pathways
EP2591114B1 (en) 2010-07-06 2016-06-08 GlaxoSmithKline Biologicals SA Immunisation of large mammals with low doses of rna
US9770463B2 (en) 2010-07-06 2017-09-26 Glaxosmithkline Biologicals Sa Delivery of RNA to different cell types
SI4005592T1 (en) 2010-07-06 2023-03-31 Glaxosmithkline Biologicals S.A. Virion-like delivery particles for self-replicating rna molecules
US9192661B2 (en) 2010-07-06 2015-11-24 Novartis Ag Delivery of self-replicating RNA using biodegradable polymer particles
BR112013000244A2 (en) 2010-07-06 2016-05-17 Novartis Ag lipid liposomes having advantageous pka for administration of rna
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
WO2012031046A2 (en) 2010-08-31 2012-03-08 Novartis Ag Lipids suitable for liposomal delivery of protein-coding rna
ES2938866T3 (en) 2010-08-31 2023-04-17 Glaxosmithkline Biologicals Sa Pegylated liposomes for delivery of RNA encoding immunogen
CN103313725B (en) 2010-09-01 2016-06-29 诺华有限公司 Immunostimulant absorption insoluble petal ion
GB201101665D0 (en) 2011-01-31 2011-03-16 Novartis Ag Immunogenic compositions
CN104531812A (en) 2010-10-01 2015-04-22 现代治疗公司 Engineered nucleic acids and methods of use thereof
ES2716243T3 (en) 2010-10-11 2019-06-11 Glaxosmithkline Biologicals Sa Antigen Supply Platforms
WO2012082914A1 (en) 2010-12-14 2012-06-21 Novartis Ag Flow cytometry analysis of materials adsorbed to metal salts
EP2655389A2 (en) 2010-12-24 2013-10-30 Novartis AG Compounds
EP2667852B1 (en) 2011-01-27 2016-11-09 GlaxoSmithKline Biologicals SA Adjuvant nanoemulsions with crystallisation inhibitors
EP2680885B8 (en) 2011-03-02 2018-07-25 GlaxoSmithKline Biologicals SA Combination vaccines with lower doses of antigen and/or adjuvant
WO2012129483A1 (en) 2011-03-24 2012-09-27 Novartis Ag Adjuvant nanoemulsions with phospholipids
WO2012135805A2 (en) 2011-03-31 2012-10-04 modeRNA Therapeutics Delivery and formulation of engineered nucleic acids
CA2836468C (en) 2011-05-17 2021-05-04 The Rockefeller University Human immunodeficiency virus neutralizing antibodies and methods of use thereof
BR112013032410A2 (en) * 2011-06-24 2017-01-17 Epitogenesis Inc pharmaceutical compositions comprising a combination of selection vehicles, vitamins, tannins and flavonoids as antigen specific immunomodulators
SG10201605537XA (en) 2011-07-06 2016-09-29 Novartis Ag Liposomes having useful n:p ratio for delivery of rna molecules
EP3854413A1 (en) 2011-07-06 2021-07-28 GlaxoSmithKline Biologicals SA Immunogenic combination compositions and uses thereof
DK2750707T3 (en) 2011-08-31 2019-02-11 Glaxosmithkline Biologicals Sa PEGYLED LIPOSOMES FOR DELIVERING IMMUNOGEN-CODING RNA
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
WO2013038375A2 (en) 2011-09-14 2013-03-21 Novartis Ag Methods for making saccharide-protein glycoconjugates
RU2707251C2 (en) 2011-10-03 2019-11-25 Модерна Терапьютикс, Инк. Modified nucleosides, nucleotides and nucleic acids and use thereof
AU2012335208B2 (en) 2011-11-07 2017-08-31 Glaxosmithkline Biologicals S.A. Carrier molecule comprising a spr0096 and a spr2021 antigen
KR20140102759A (en) 2011-12-16 2014-08-22 모더나 세라퓨틱스, 인코포레이티드 Modified nucleoside, nucleotide, and nucleic acid compositions
JP2015510872A (en) 2012-03-07 2015-04-13 ノバルティス アーゲー Enhanced formulation of Streptococcus pneumoniae antigen
ES2597755T3 (en) 2012-03-07 2017-01-20 Glaxosmithkline Biologicals Sa Arginine salts of a TLR7 agonist
RU2014140521A (en) 2012-03-08 2016-04-27 Новартис Аг ADJUVANT COMPOSITIONS OF BOOSTER VACCINES
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
EP2833892A4 (en) 2012-04-02 2016-07-20 Moderna Therapeutics Inc Modified polynucleotides for the production of oncology-related proteins and peptides
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
JP2015518845A (en) 2012-05-22 2015-07-06 ノバルティス アーゲー Neisseria meningitidis serogroup X conjugate
MX363529B (en) 2012-09-18 2019-03-27 Novartis Ag Outer membrane vesicles.
JP6144355B2 (en) 2012-11-26 2017-06-07 モデルナティエックス インコーポレイテッドModernaTX,Inc. Chemically modified mRNA
CN105188747A (en) 2013-02-01 2015-12-23 葛兰素史密斯克莱生物公司 Intradermal delivery of immunological compositions comprising TOLL-like receptor agonists
BR112015021791B1 (en) 2013-03-08 2022-08-30 Novartis Ag CATIONIC LIPID COMPOUNDS AND LIPID AND PHARMACEUTICAL COMPOSITIONS
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
WO2015048744A2 (en) 2013-09-30 2015-04-02 Moderna Therapeutics, Inc. Polynucleotides encoding immune modulating polypeptides
US10323076B2 (en) 2013-10-03 2019-06-18 Modernatx, Inc. Polynucleotides encoding low density lipoprotein receptor
ES2806575T3 (en) 2013-11-01 2021-02-18 Curevac Ag Modified RNA with decreased immunostimulatory properties
EP3872066A1 (en) 2013-12-19 2021-09-01 Novartis AG Lipids and lipid compositions for the delivery of active agents
EP3083579B1 (en) 2013-12-19 2022-01-26 Novartis AG Lipids and lipid compositions for the delivery of active agents
US10342761B2 (en) 2014-07-16 2019-07-09 Novartis Ag Method of encapsulating a nucleic acid in a lipid nanoparticle host
WO2016037053A1 (en) 2014-09-05 2016-03-10 Novartis Ag Lipids and lipid compositions for the delivery of active agents
EP3061826A1 (en) 2015-02-27 2016-08-31 Novartis AG Flavivirus replicons
ES2937963T3 (en) 2015-07-21 2023-04-03 Modernatx Inc Infectious disease vaccines
US11364292B2 (en) 2015-07-21 2022-06-21 Modernatx, Inc. CHIKV RNA vaccines
EP3364950A4 (en) 2015-10-22 2019-10-23 ModernaTX, Inc. Tropical disease vaccines
WO2017083337A1 (en) * 2015-11-10 2017-05-18 Ohio State Innovation Foundation Methods and compositions related to accelerated humoral affinity
EP3439704A1 (en) 2016-04-05 2019-02-13 GSK Vaccines S.r.l. Immunogenic compositions
EP3681514A4 (en) 2017-09-14 2021-07-14 ModernaTX, Inc. Zika virus rna vaccines
KR20200123436A (en) 2018-02-12 2020-10-29 이니뮨 코퍼레이션 Toll-like receptor ligand
IL302449A (en) 2020-11-04 2023-06-01 Eligo Bioscience Cutibacterium acnes recombinant phages, method of production and uses thereof
WO2023021427A1 (en) 2021-08-16 2023-02-23 Glaxosmithkline Biologicals Sa Freeze-drying of lipid nanoparticles (lnps) encapsulating rna and formulations thereof
WO2023021421A1 (en) 2021-08-16 2023-02-23 Glaxosmithkline Biologicals Sa Low-dose lyophilized rna vaccines and methods for preparing and using the same

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869608A (en) * 1989-03-17 1999-02-09 The United States Of America As Represented By The Department Of Health And Human Services Nucleotide and amino acid sequences of the four variable domains of the major outer membrane proteins of Chlamydia trachomatis
PT1007685E (en) * 1997-06-23 2006-08-31 Loke Diagnostics Aps PROTEINS EXPOSED ON THE SURFACE OF CHLAMYDIA PNEUMONIAE
BR9814878A (en) * 1997-11-21 2000-10-03 Genset Sa Genetic sequence and polypeptides of chlamydia pneumoniae, fragments thereof and uses thereof, in particular for the diagnosis, prevention and treatment of infection
PT1032674E (en) * 1997-11-21 2007-03-30 Serono Genetics Inst Sa (chlamydia pneumoniae) genomic sequence and polypeptides, fragments thereof and uses thereof, in particular for the diagnosis, prevention and treatment of infection
KR100735651B1 (en) 1997-11-28 2007-07-06 세로노 제네틱스 인스티튜트 에스.에이. Chlamydia trachomatis genomic sequence and polypeptides, fragments thereof and uses thereof, in particular for the diagnosis, prevention and treatment of infection
US6248329B1 (en) * 1998-06-01 2001-06-19 Ramaswamy Chandrashekar Parasitic helminth cuticlin nucleic acid molecules and uses thereof
WO2000027994A2 (en) * 1998-11-12 2000-05-18 The Regents Of The University Of California Chlamydia pneumoniae genome sequence
US6822071B1 (en) * 1998-11-12 2004-11-23 The Regents Of The University Of California Polypeptides from Chlamydia pneumoniae and their use in the diagnosis, prevention and treatment of disease
US6565856B1 (en) 1998-12-08 2003-05-20 Corixa Corporation Compounds and methods for treatment and diagnosis of chlamydial infection
IL143531A0 (en) * 1998-12-08 2002-04-21 Corixa Corp Polypeptides containing an antigenic portion of a chlamydia antigen, dna sequences encoding said polypeptides and pharmaceutical compositions and vaccines containing the same
US20020061848A1 (en) 2000-07-20 2002-05-23 Ajay Bhatia Compounds and methods for treatment and diagnosis of chlamydial infection
GB9828000D0 (en) 1998-12-18 1999-02-10 Chiron Spa Antigens
GB9902555D0 (en) 1999-02-05 1999-03-24 Neutec Pharma Plc Medicament
CA2373021A1 (en) 1999-05-03 2000-11-09 Aventis Pasteur Limited Chlamydia antigens and corresponding dna fragments and uses thereof
JP4667694B2 (en) 1999-09-20 2011-04-13 サノフィ、パストゥール、リミテッド Chlamydia antigen and corresponding DNA fragments and uses thereof
US6632663B1 (en) 1999-09-22 2003-10-14 Aventis Pasteur Limited DNA immunization against chlamydia infection
EP1240331B1 (en) 1999-12-22 2010-04-07 Aventis Pasteur Limited Chlamydia antigens and corresponding dna fragments and uses thereof
US20020132994A1 (en) * 2000-04-04 2002-09-19 Murdin Andrew D. Chlamydia antigens and corresponding DNA fragments and uses thereof
EP1278855B1 (en) 2000-04-21 2008-03-12 Corixa Corporation Compounds and methods for treatment and diagnosis of chlamydial infection
EP1282718B1 (en) 2000-05-08 2006-12-20 Sanofi Pasteur Limited Chlamydia antigens and corresponding dna fragments and uses thereof
EP1297005B1 (en) 2000-07-03 2009-08-26 Novartis Vaccines and Diagnostics S.r.l. Immunisation against chlamydia pneumoniae

Also Published As

Publication number Publication date
US20100056447A1 (en) 2010-03-04
EP1297005A2 (en) 2003-04-02
ATE440861T1 (en) 2009-09-15
EP2166019A3 (en) 2010-06-09
JP2012147798A (en) 2012-08-09
US20040005667A1 (en) 2004-01-08
CA2414884A1 (en) 2002-01-10
WO2002002606A2 (en) 2002-01-10
DE60139690D1 (en) 2009-10-08
JP2004502415A (en) 2004-01-29
US20120171236A1 (en) 2012-07-05
US20070116726A1 (en) 2007-05-24
WO2002002606A3 (en) 2002-06-06
EP1297005B1 (en) 2009-08-26
EP2166019A2 (en) 2010-03-24

Similar Documents

Publication Publication Date Title
AU2001276619A1 (en) Immunisation against chlamydia pneumoniae
EP2168596A3 (en) Immunisation against chlamydia trachomatis
WO2000022430A3 (en) Neisseria genomic sequences and methods of their use
WO2000039299A3 (en) Streptococcus antigens
NO976119L (en) OMP26 antigen from Haemophilus influenzae
EP1935991A3 (en) Nucleic acid vaccines for prevention of flavivirus infection
EP1731166A3 (en) Streptococcus pneumoniae proteins and vaccines
EP2275553A3 (en) Neisserial antigenic peptides
ATE375391T1 (en) CHLAMYDIA ANTIGENS AND CORRESPONDING DNA FRAGMENTS AND THEIR USES
EP1586646A3 (en) Lawsonia intracellularis vaccine
WO2000005378A3 (en) Streptococcus suis vaccines and diagnostic tests
EP1220925B8 (en) Chlamydia antigens and corresponding dna fragments and uses thereof
CA2294701A1 (en) Surface antigens and proteins useful in compositions for the diagnosis and prevention of lyme disease
WO2004020609A3 (en) Streptococcus pneumoniae antigens for diagnosis, treatment and prevention of active infection
WO2001046225A3 (en) Chlamydia antigens and corresponding dna fragments and uses thereof
EP2172214A3 (en) Chlamydia antigens and corresponding DNA fragments and uses thereof
EP2088197A3 (en) Haemophilus influenzae antigens and corresponding DNA fragments
WO2000044392A3 (en) Identification of specific differentially expressed mycobacterial antigens
EP1020516A3 (en) Leptospira vaccine antigens for the prevention of leptospirosis
Kunkle Molecular cloning and characterization of a unique 21-kilodalton antigen of Serpulina hyodysenteriae.
EP1219635A3 (en) Chlamydia pneumoniae antigenes
TH44467A (en) Campylobacter vaccine
WO2002034782A3 (en) Endozepine-like polypeptide nov1 and nucleic acid encoding the same
WO2000046242A3 (en) 19 KILODALTON PROTEIN OF $i(HELICOBACTER PYLORI)