ZA200400973B - Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient. - Google Patents
Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient. Download PDFInfo
- Publication number
- ZA200400973B ZA200400973B ZA200400973A ZA200400973A ZA200400973B ZA 200400973 B ZA200400973 B ZA 200400973B ZA 200400973 A ZA200400973 A ZA 200400973A ZA 200400973 A ZA200400973 A ZA 200400973A ZA 200400973 B ZA200400973 B ZA 200400973B
- Authority
- ZA
- South Africa
- Prior art keywords
- phenyl
- methyl
- propanoic acid
- carbamoyl
- butyl
- Prior art date
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- -1 Carboxylic acid derivative compounds Chemical class 0.000 title claims description 66
- 150000001875 compounds Chemical class 0.000 title claims description 61
- 239000004480 active ingredient Substances 0.000 title description 4
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 125000002947 alkylene group Chemical group 0.000 claims description 145
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 102
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 96
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 65
- 229910052757 nitrogen Inorganic materials 0.000 claims description 51
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 50
- 125000004429 atom Chemical group 0.000 claims description 48
- 229910052760 oxygen Inorganic materials 0.000 claims description 48
- 229910052717 sulfur Inorganic materials 0.000 claims description 48
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 45
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 45
- 239000001301 oxygen Substances 0.000 claims description 45
- 239000011593 sulfur Substances 0.000 claims description 45
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 44
- 229910052739 hydrogen Inorganic materials 0.000 claims description 40
- 239000001257 hydrogen Substances 0.000 claims description 40
- 229910052736 halogen Inorganic materials 0.000 claims description 35
- 150000002367 halogens Chemical class 0.000 claims description 35
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 35
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 33
- 229910052799 carbon Inorganic materials 0.000 claims description 31
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 30
- 150000003839 salts Chemical class 0.000 claims description 27
- 125000001424 substituent group Chemical group 0.000 claims description 26
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 23
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims description 22
- 206010028980 Neoplasm Diseases 0.000 claims description 20
- 201000011510 cancer Diseases 0.000 claims description 20
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 20
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 19
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 18
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 18
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 17
- 125000000304 alkynyl group Chemical group 0.000 claims description 17
- 231100000252 nontoxic Toxicity 0.000 claims description 17
- 230000003000 nontoxic effect Effects 0.000 claims description 17
- 125000002252 acyl group Chemical group 0.000 claims description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 15
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 14
- 125000004043 oxo group Chemical group O=* 0.000 claims description 14
- 150000003431 steroids Chemical class 0.000 claims description 13
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims description 12
- 206010027476 Metastases Diseases 0.000 claims description 12
- 125000004450 alkenylene group Chemical group 0.000 claims description 12
- 230000009401 metastasis Effects 0.000 claims description 12
- 108020003175 receptors Proteins 0.000 claims description 12
- 102000005962 receptors Human genes 0.000 claims description 12
- 125000003545 alkoxy group Chemical group 0.000 claims description 11
- 125000000217 alkyl group Chemical group 0.000 claims description 11
- 125000004419 alkynylene group Chemical group 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- 150000003536 tetrazoles Chemical class 0.000 claims description 10
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 9
- 208000002193 Pain Diseases 0.000 claims description 9
- 208000035475 disorder Diseases 0.000 claims description 9
- 206010003210 Arteriosclerosis Diseases 0.000 claims description 8
- 208000004454 Hyperalgesia Diseases 0.000 claims description 8
- 125000004414 alkyl thio group Chemical group 0.000 claims description 8
- 210000000988 bone and bone Anatomy 0.000 claims description 8
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 8
- 210000000056 organ Anatomy 0.000 claims description 8
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims description 7
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 7
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims description 7
- 201000010099 disease Diseases 0.000 claims description 7
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims description 6
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims description 6
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims description 6
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 6
- 125000005842 heteroatom Chemical group 0.000 claims description 6
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 6
- 125000006591 (C2-C6) alkynylene group Chemical group 0.000 claims description 5
- 208000024827 Alzheimer disease Diseases 0.000 claims description 5
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 5
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims description 5
- 208000011231 Crohn disease Diseases 0.000 claims description 5
- 206010012438 Dermatitis atopic Diseases 0.000 claims description 5
- 206010012442 Dermatitis contact Diseases 0.000 claims description 5
- 206010019233 Headaches Diseases 0.000 claims description 5
- 206010036018 Pollakiuria Diseases 0.000 claims description 5
- 208000001647 Renal Insufficiency Diseases 0.000 claims description 5
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 5
- 208000002205 allergic conjunctivitis Diseases 0.000 claims description 5
- 230000033115 angiogenesis Effects 0.000 claims description 5
- 208000006673 asthma Diseases 0.000 claims description 5
- 208000024998 atopic conjunctivitis Diseases 0.000 claims description 5
- 201000008937 atopic dermatitis Diseases 0.000 claims description 5
- 208000010247 contact dermatitis Diseases 0.000 claims description 5
- 201000006370 kidney failure Diseases 0.000 claims description 5
- 201000008383 nephritis Diseases 0.000 claims description 5
- 208000010110 spontaneous platelet aggregation Diseases 0.000 claims description 5
- 208000022934 urinary frequency Diseases 0.000 claims description 5
- 230000036318 urination frequency Effects 0.000 claims description 5
- 125000006590 (C2-C6) alkenylene group Chemical group 0.000 claims description 4
- 206010000242 Abortion threatened Diseases 0.000 claims description 4
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- 208000037260 Atherosclerotic Plaque Diseases 0.000 claims description 4
- 208000020084 Bone disease Diseases 0.000 claims description 4
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- 206010012735 Diarrhoea Diseases 0.000 claims description 4
- 208000005171 Dysmenorrhea Diseases 0.000 claims description 4
- 206010013935 Dysmenorrhoea Diseases 0.000 claims description 4
- 208000005189 Embolism Diseases 0.000 claims description 4
- 201000009273 Endometriosis Diseases 0.000 claims description 4
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- 206010018691 Granuloma Diseases 0.000 claims description 4
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- 208000037147 Hypercalcaemia Diseases 0.000 claims description 4
- 208000035154 Hyperesthesia Diseases 0.000 claims description 4
- 206010020772 Hypertension Diseases 0.000 claims description 4
- 208000011200 Kawasaki disease Diseases 0.000 claims description 4
- 208000004852 Lung Injury Diseases 0.000 claims description 4
- 208000034486 Multi-organ failure Diseases 0.000 claims description 4
- 208000010718 Multiple Organ Failure Diseases 0.000 claims description 4
- 206010030113 Oedema Diseases 0.000 claims description 4
- 206010036595 Premature delivery Diseases 0.000 claims description 4
- 206010036618 Premenstrual syndrome Diseases 0.000 claims description 4
- 208000003251 Pruritus Diseases 0.000 claims description 4
- 201000004681 Psoriasis Diseases 0.000 claims description 4
- 208000012545 Psychophysiologic disease Diseases 0.000 claims description 4
- 206010037660 Pyrexia Diseases 0.000 claims description 4
- 208000004680 Rectal Fistula Diseases 0.000 claims description 4
- 206010039085 Rhinitis allergic Diseases 0.000 claims description 4
- 206010051379 Systemic Inflammatory Response Syndrome Diseases 0.000 claims description 4
- 208000007536 Thrombosis Diseases 0.000 claims description 4
- 208000025865 Ulcer Diseases 0.000 claims description 4
- 208000024780 Urticaria Diseases 0.000 claims description 4
- 206010046996 Varicose vein Diseases 0.000 claims description 4
- 201000004810 Vascular dementia Diseases 0.000 claims description 4
- 102100026383 Vasopressin-neurophysin 2-copeptin Human genes 0.000 claims description 4
- 230000004913 activation Effects 0.000 claims description 4
- 201000010105 allergic rhinitis Diseases 0.000 claims description 4
- 206010053552 allodynia Diseases 0.000 claims description 4
- 206010002156 anal fistula Diseases 0.000 claims description 4
- 208000011775 arteriosclerosis disease Diseases 0.000 claims description 4
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 4
- 201000001883 cholelithiasis Diseases 0.000 claims description 4
- 201000010064 diabetes insipidus Diseases 0.000 claims description 4
- 238000000502 dialysis Methods 0.000 claims description 4
- YUCFVHQCAFKDQG-UHFFFAOYSA-N fluoromethane Chemical compound F[CH] YUCFVHQCAFKDQG-UHFFFAOYSA-N 0.000 claims description 4
- 208000007565 gingivitis Diseases 0.000 claims description 4
- 230000000148 hypercalcaemia Effects 0.000 claims description 4
- 208000030915 hypercalcemia disease Diseases 0.000 claims description 4
- 208000026278 immune system disease Diseases 0.000 claims description 4
- 208000017169 kidney disease Diseases 0.000 claims description 4
- 201000003723 learning disability Diseases 0.000 claims description 4
- 208000001725 mucocutaneous lymph node syndrome Diseases 0.000 claims description 4
- 208000029744 multiple organ dysfunction syndrome Diseases 0.000 claims description 4
- 208000010125 myocardial infarction Diseases 0.000 claims description 4
- 208000031225 myocardial ischemia Diseases 0.000 claims description 4
- 210000005036 nerve Anatomy 0.000 claims description 4
- 210000002569 neuron Anatomy 0.000 claims description 4
- 208000003278 patent ductus arteriosus Diseases 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 4
- 230000035755 proliferation Effects 0.000 claims description 4
- 208000020016 psychiatric disease Diseases 0.000 claims description 4
- 230000009467 reduction Effects 0.000 claims description 4
- 230000001850 reproductive effect Effects 0.000 claims description 4
- 206010039083 rhinitis Diseases 0.000 claims description 4
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- 230000009885 systemic effect Effects 0.000 claims description 4
- 208000002419 toxicodendron dermatitis Diseases 0.000 claims description 4
- 231100000397 ulcer Toxicity 0.000 claims description 4
- 230000002485 urinary effect Effects 0.000 claims description 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 3
- 150000001412 amines Chemical class 0.000 claims description 3
- 101150114348 cycs gene Proteins 0.000 claims description 3
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 3
- 125000000623 heterocyclic group Chemical group 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 201000002282 venous insufficiency Diseases 0.000 claims description 3
- ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 claims description 2
- PCJFEVUKVKQSSL-UHFFFAOYSA-N 2h-1,2,4-oxadiazol-5-one Chemical compound O=C1N=CNO1 PCJFEVUKVKQSSL-UHFFFAOYSA-N 0.000 claims description 2
- IGAVZWMNOPFOCW-UHFFFAOYSA-N 2h-1,2,4-thiadiazol-5-one Chemical compound O=C1NC=NS1 IGAVZWMNOPFOCW-UHFFFAOYSA-N 0.000 claims description 2
- YSVFAMDLJASIGW-UHFFFAOYSA-N 5h-1,2,3,5-oxathiadiazole 2-oxide Chemical compound O=S1NC=NO1 YSVFAMDLJASIGW-UHFFFAOYSA-N 0.000 claims description 2
- 125000003320 C2-C6 alkenyloxy group Chemical group 0.000 claims description 2
- 125000005133 alkynyloxy group Chemical group 0.000 claims description 2
- 125000002837 carbocyclic group Chemical group 0.000 claims description 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 63
- DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 claims 63
- 235000019260 propionic acid Nutrition 0.000 claims 63
- LKJPYSCBVHEWIU-UHFFFAOYSA-N N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide Chemical compound C=1C=C(C#N)C(C(F)(F)F)=CC=1NC(=O)C(O)(C)CS(=O)(=O)C1=CC=C(F)C=C1 LKJPYSCBVHEWIU-UHFFFAOYSA-N 0.000 claims 23
- JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 claims 13
- 125000004494 ethyl ester group Chemical group 0.000 claims 7
- 208000028169 periodontal disease Diseases 0.000 claims 6
- 239000000126 substance Substances 0.000 claims 6
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims 4
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 125000001325 propanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 claims 4
- 208000005641 Adenomyosis Diseases 0.000 claims 3
- 208000006069 Corneal Opacity Diseases 0.000 claims 3
- 206010014418 Electrolyte imbalance Diseases 0.000 claims 3
- 206010015150 Erythema Diseases 0.000 claims 3
- 241001123008 Leukoma Species 0.000 claims 3
- 206010067125 Liver injury Diseases 0.000 claims 3
- 206010028748 Nasal obstruction Diseases 0.000 claims 3
- 206010064050 Polymenorrhagia Diseases 0.000 claims 3
- 208000005985 Threatened Abortion Diseases 0.000 claims 3
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- 206010069363 Traumatic lung injury Diseases 0.000 claims 3
- 231100000354 acute hepatitis Toxicity 0.000 claims 3
- 230000036506 anxiety Effects 0.000 claims 3
- 239000008280 blood Substances 0.000 claims 3
- 210000004369 blood Anatomy 0.000 claims 3
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- 230000030833 cell death Effects 0.000 claims 3
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- 230000008030 elimination Effects 0.000 claims 3
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- 231100000321 erythema Toxicity 0.000 claims 3
- 231100000753 hepatic injury Toxicity 0.000 claims 3
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- 201000010875 transient cerebral ischemia Diseases 0.000 claims 3
- 238000002054 transplantation Methods 0.000 claims 3
- XYXFJVUTWBYVNA-UHFFFAOYSA-N 1-(3,4-difluorophenyl)sulfonyl-3-[[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]methyl]urea Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)NCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CN1N=CC=C1 XYXFJVUTWBYVNA-UHFFFAOYSA-N 0.000 claims 2
- PELNAJMIORGITF-UHFFFAOYSA-N 1-(benzenesulfonyl)-3-[[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]methyl]urea Chemical compound C=1C=CC=CC=1S(=O)(=O)NC(=O)NCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CN1C=CC=N1 PELNAJMIORGITF-UHFFFAOYSA-N 0.000 claims 2
- RXUKKEFOSBJYMV-UHFFFAOYSA-N 2-(3-hydroxypropyl)-n-(3-methyl-1-phenylbutyl)-5-(phenoxymethyl)benzamide Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCCO)=CC=1COC1=CC=CC=C1 RXUKKEFOSBJYMV-UHFFFAOYSA-N 0.000 claims 2
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims 2
- VAOOMXHPPBCWPF-UHFFFAOYSA-N 3-[4-(methanesulfonamido)-2-(2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound CS(=O)(=O)NC1=CC=C(CCC(O)=O)C(OCCC=2C=C3C=CC=CC3=CC=2)=C1 VAOOMXHPPBCWPF-UHFFFAOYSA-N 0.000 claims 2
- WRLIEFHKRDZNTJ-UHFFFAOYSA-N 3-[4-[[2,4-bis(trifluoromethyl)phenyl]methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=C(C(F)(F)F)C=C1C(F)(F)F WRLIEFHKRDZNTJ-UHFFFAOYSA-N 0.000 claims 2
- IPWMWQIQORUVDM-UHFFFAOYSA-N 5-[2-[2-(4-methyl-2-phenylpentoxy)-4-(phenoxymethyl)phenyl]ethyl]-2h-tetrazole Chemical compound C=1C=CC=CC=1C(CC(C)C)COC(C(=CC=1)CCC=2NN=NN=2)=CC=1COC1=CC=CC=C1 IPWMWQIQORUVDM-UHFFFAOYSA-N 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 150000004702 methyl esters Chemical class 0.000 claims 2
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 claims 2
- AGSLLLYIIIJZJA-UHFFFAOYSA-N n-[1-(4-fluorophenyl)-3-methylbutyl]-2-(3-hydroxypropyl)-5-(phenoxymethyl)benzamide Chemical compound C=1C=C(F)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCCO)=CC=1COC1=CC=CC=C1 AGSLLLYIIIJZJA-UHFFFAOYSA-N 0.000 claims 2
- 230000003449 preventive effect Effects 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- CMKDEDORGBLPQC-MDZDMXLPSA-N (e)-3-[2-(2-benzamidoethoxy)-4-(pyrazol-1-ylmethyl)phenyl]prop-2-enoic acid Chemical compound C1=C(OCCNC(=O)C=2C=CC=CC=2)C(/C=C/C(=O)O)=CC=C1CN1C=CC=N1 CMKDEDORGBLPQC-MDZDMXLPSA-N 0.000 claims 1
- DBJSQDDLIPQGMI-MDZDMXLPSA-N (e)-3-[2-(2-hydroxy-3-phenoxypropoxy)-4-(pyrazol-1-ylmethyl)phenyl]prop-2-enoic acid Chemical compound C=1C(CN2N=CC=C2)=CC=C(\C=C\C(O)=O)C=1OCC(O)COC1=CC=CC=C1 DBJSQDDLIPQGMI-MDZDMXLPSA-N 0.000 claims 1
- LWDHVHCQQLCUFV-VAWYXSNFSA-N (e)-3-[2-(2-methoxy-2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]prop-2-enoic acid Chemical compound C=1C=C2C=CC=CC2=CC=1C(OC)COC(C(=CC=1)\C=C\C(O)=O)=CC=1CN1C=CC=N1 LWDHVHCQQLCUFV-VAWYXSNFSA-N 0.000 claims 1
- PDCVDUIICPSRQT-ZHACJKMWSA-N (e)-3-[2-(2-methoxy-3-phenoxypropoxy)-4-(pyrazol-1-ylmethyl)phenyl]prop-2-enoic acid Chemical compound C=1C(CN2N=CC=C2)=CC=C(\C=C\C(O)=O)C=1OCC(OC)COC1=CC=CC=C1 PDCVDUIICPSRQT-ZHACJKMWSA-N 0.000 claims 1
- DGOVKNCDEPIMDQ-VAWYXSNFSA-N (e)-3-[2-(2-naphthalen-1-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]prop-2-enoic acid Chemical compound C1=C(OCCC=2C3=CC=CC=C3C=CC=2)C(/C=C/C(=O)O)=CC=C1CN1C=CC=N1 DGOVKNCDEPIMDQ-VAWYXSNFSA-N 0.000 claims 1
- GNYRRSIQXMFLSN-ZRDIBKRKSA-N (e)-3-[2-(2-naphthalen-2-ylethoxy)-4-(2-oxopyrrolidin-1-yl)phenyl]prop-2-enoic acid Chemical compound C1=C(OCCC=2C=C3C=CC=CC3=CC=2)C(/C=C/C(=O)O)=CC=C1N1CCCC1=O GNYRRSIQXMFLSN-ZRDIBKRKSA-N 0.000 claims 1
- HHJYFJGRTMWIMW-CCEZHUSRSA-N (e)-3-[2-(2-naphthalen-2-ylethoxy)-4-(phenoxymethyl)phenyl]prop-2-enoic acid Chemical compound C1=C(OCCC=2C=C3C=CC=CC3=CC=2)C(/C=C/C(=O)O)=CC=C1COC1=CC=CC=C1 HHJYFJGRTMWIMW-CCEZHUSRSA-N 0.000 claims 1
- DAZSISWMTCUANG-CCEZHUSRSA-N (e)-3-[2-(2-naphthalen-2-ylethoxy)-4-(phenylcarbamoyl)phenyl]prop-2-enoic acid Chemical compound C1=C(OCCC=2C=C3C=CC=CC3=CC=2)C(/C=C/C(=O)O)=CC=C1C(=O)NC1=CC=CC=C1 DAZSISWMTCUANG-CCEZHUSRSA-N 0.000 claims 1
- BAXFMLZOUPMNQW-ZHACJKMWSA-N (e)-3-[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]prop-2-enoic acid Chemical compound C1=C(OCCC=2C=C3C=CC=CC3=CC=2)C(/C=C/C(=O)O)=CC=C1CN1C=CC=N1 BAXFMLZOUPMNQW-ZHACJKMWSA-N 0.000 claims 1
- XGKGVJIBKHFKMF-VAWYXSNFSA-N (e)-3-[2-(2-naphthalen-2-ylethoxy)-4-(thiophen-2-ylmethyl)phenyl]prop-2-enoic acid Chemical compound C1=C(OCCC=2C=C3C=CC=CC3=CC=2)C(/C=C/C(=O)O)=CC=C1CC1=CC=CS1 XGKGVJIBKHFKMF-VAWYXSNFSA-N 0.000 claims 1
- IUFUZFZBQCQRIC-MDZDMXLPSA-N (e)-3-[2-(2-naphthalen-2-ylethoxy)-4-(thiophen-3-ylmethyl)phenyl]prop-2-enoic acid Chemical compound C1=C(OCCC=2C=C3C=CC=CC3=CC=2)C(/C=C/C(=O)O)=CC=C1CC=1C=CSC=1 IUFUZFZBQCQRIC-MDZDMXLPSA-N 0.000 claims 1
- IXFAJVJBLAGTDS-FYWRMAATSA-N (e)-3-[2-(2-naphthalen-2-ylethoxy)-4-phenylmethoxyphenyl]prop-2-enoic acid Chemical compound C1=C(OCCC=2C=C3C=CC=CC3=CC=2)C(/C=C/C(=O)O)=CC=C1OCC1=CC=CC=C1 IXFAJVJBLAGTDS-FYWRMAATSA-N 0.000 claims 1
- ARYKMVKAKGRDIV-PKNBQFBNSA-N (e)-3-[2-(2-naphthalen-2-yloxyethyl)-4-(pyrazol-1-ylmethyl)phenyl]prop-2-enoic acid Chemical compound C1=C(CCOC=2C=C3C=CC=CC3=CC=2)C(/C=C/C(=O)O)=CC=C1CN1C=CC=N1 ARYKMVKAKGRDIV-PKNBQFBNSA-N 0.000 claims 1
- LTGBSDAYRLAFAT-VAWYXSNFSA-N (e)-3-[2-(2-naphthalen-2-ylpropoxy)-4-(pyrazol-1-ylmethyl)phenyl]prop-2-enoic acid Chemical compound C=1C=C2C=CC=CC2=CC=1C(C)COC(C(=CC=1)\C=C\C(O)=O)=CC=1CN1C=CC=N1 LTGBSDAYRLAFAT-VAWYXSNFSA-N 0.000 claims 1
- LRVBFTAFGBXKHJ-MDZDMXLPSA-N (e)-3-[2-(2-phenylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]prop-2-enoic acid Chemical compound C1=C(OCCC=2C=CC=CC=2)C(/C=C/C(=O)O)=CC=C1CN1C=CC=N1 LRVBFTAFGBXKHJ-MDZDMXLPSA-N 0.000 claims 1
- UPVSIUBKAPKUEE-OUKQBFOZSA-N (e)-3-[2-(3-naphthalen-2-ylpropoxy)-4-(pyrazol-1-ylmethyl)phenyl]prop-2-enoic acid Chemical compound C1=C(OCCCC=2C=C3C=CC=CC3=CC=2)C(/C=C/C(=O)O)=CC=C1CN1C=CC=N1 UPVSIUBKAPKUEE-OUKQBFOZSA-N 0.000 claims 1
- DUPZKNKTGWMRIJ-OUKQBFOZSA-N (e)-3-[2-(3-phenylpropyl)-4-(pyrazol-1-ylmethyl)phenyl]prop-2-enoic acid Chemical compound C1=C(CCCC=2C=CC=CC=2)C(/C=C/C(=O)O)=CC=C1CN1C=CC=N1 DUPZKNKTGWMRIJ-OUKQBFOZSA-N 0.000 claims 1
- JUCKHDRDJRUTMA-FOCLMDBBSA-N (e)-3-[2-(naphthalen-1-ylmethylcarbamoyl)-4-(phenoxymethyl)phenyl]prop-2-enoic acid Chemical compound C1=C(C(=O)NCC=2C3=CC=CC=C3C=CC=2)C(/C=C/C(=O)O)=CC=C1COC1=CC=CC=C1 JUCKHDRDJRUTMA-FOCLMDBBSA-N 0.000 claims 1
- IGZUJWJKOUVCCV-VAWYXSNFSA-N (e)-3-[2-(naphthalen-1-ylmethylcarbamoyl)-4-(pyrazol-1-ylmethyl)phenyl]prop-2-enoic acid Chemical compound C1=C(C(=O)NCC=2C3=CC=CC=C3C=CC=2)C(/C=C/C(=O)O)=CC=C1CN1C=CC=N1 IGZUJWJKOUVCCV-VAWYXSNFSA-N 0.000 claims 1
- FDLIGVMZGBDMAC-ZHACJKMWSA-N (e)-3-[2-(naphthalen-2-ylmethoxy)-4-(pyrazol-1-ylmethyl)phenyl]prop-2-enoic acid Chemical compound C1=C(OCC=2C=C3C=CC=CC3=CC=2)C(/C=C/C(=O)O)=CC=C1CN1C=CC=N1 FDLIGVMZGBDMAC-ZHACJKMWSA-N 0.000 claims 1
- BASHREBKZTWARE-ZHACJKMWSA-N (e)-3-[2-(naphthalen-2-ylmethoxymethyl)-4-(pyrazol-1-ylmethyl)phenyl]prop-2-enoic acid Chemical compound C1=C(COCC=2C=C3C=CC=CC3=CC=2)C(/C=C/C(=O)O)=CC=C1CN1C=CC=N1 BASHREBKZTWARE-ZHACJKMWSA-N 0.000 claims 1
- FZLDDRZNOQFNTF-CCEZHUSRSA-N (e)-3-[2-(naphthalen-2-ylmethyl)-4-(phenoxymethyl)phenyl]prop-2-enoic acid Chemical compound C1=C(CC=2C=C3C=CC=CC3=CC=2)C(/C=C/C(=O)O)=CC=C1COC1=CC=CC=C1 FZLDDRZNOQFNTF-CCEZHUSRSA-N 0.000 claims 1
- LGAPOPZRMXBNKY-ZHACJKMWSA-N (e)-3-[2-(naphthalen-2-ylmethyl)-4-(pyrazol-1-ylmethyl)phenyl]prop-2-enoic acid Chemical compound C1=C(CC=2C=C3C=CC=CC3=CC=2)C(/C=C/C(=O)O)=CC=C1CN1C=CC=N1 LGAPOPZRMXBNKY-ZHACJKMWSA-N 0.000 claims 1
- CDJQYBJNHGADLJ-CCEZHUSRSA-N (e)-3-[2-(naphthalen-2-ylmethylcarbamoyl)-4-(phenoxymethyl)phenyl]prop-2-enoic acid Chemical compound C1=C(C(=O)NCC=2C=C3C=CC=CC3=CC=2)C(/C=C/C(=O)O)=CC=C1COC1=CC=CC=C1 CDJQYBJNHGADLJ-CCEZHUSRSA-N 0.000 claims 1
- MVNNQZZTPSSSRU-ZHACJKMWSA-N (e)-3-[2-(naphthalen-2-ylmethylcarbamoyl)-4-(pyrazol-1-ylmethyl)phenyl]prop-2-enoic acid Chemical compound C1=C(C(=O)NCC=2C=C3C=CC=CC3=CC=2)C(/C=C/C(=O)O)=CC=C1CN1C=CC=N1 MVNNQZZTPSSSRU-ZHACJKMWSA-N 0.000 claims 1
- NEGWADAAWBEFKD-ZHACJKMWSA-N (e)-3-[2-[(2-naphthalen-2-ylacetyl)amino]-4-(pyrazol-1-ylmethyl)phenyl]prop-2-enoic acid Chemical compound C1=C(NC(=O)CC=2C=C3C=CC=CC3=CC=2)C(/C=C/C(=O)O)=CC=C1CN1C=CC=N1 NEGWADAAWBEFKD-ZHACJKMWSA-N 0.000 claims 1
- TUYKMTMBIUKUBT-FOCLMDBBSA-N (e)-3-[2-[(3-methyl-1-phenylbutyl)carbamoyl]-4-(phenoxymethyl)phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)\C=C\C(O)=O)=CC=1COC1=CC=CC=C1 TUYKMTMBIUKUBT-FOCLMDBBSA-N 0.000 claims 1
- RBSYQABNZULGRB-FOCLMDBBSA-N (e)-3-[2-[(4-methyl-2-phenylpentanoyl)amino]-4-(phenoxymethyl)phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)C(=O)NC(C(=CC=1)\C=C\C(O)=O)=CC=1COC1=CC=CC=C1 RBSYQABNZULGRB-FOCLMDBBSA-N 0.000 claims 1
- BTYAIBVIXHOBDX-IUZWSJCJSA-N (e)-3-[2-[(e)-4-phenylbut-3-enoxy]-4-(pyrazol-1-ylmethyl)phenyl]prop-2-enoic acid Chemical compound C1=C(OCC\C=C\C=2C=CC=CC=2)C(/C=C/C(=O)O)=CC=C1CN1C=CC=N1 BTYAIBVIXHOBDX-IUZWSJCJSA-N 0.000 claims 1
- TXCPSHSHUJDGGN-CMDGGOBGSA-N (e)-3-[2-[2-(2,3-dihydro-1,4-benzodioxin-3-yl)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]prop-2-enoic acid Chemical compound C1=C(OCCC2OC3=CC=CC=C3OC2)C(/C=C/C(=O)O)=CC=C1CN1C=CC=N1 TXCPSHSHUJDGGN-CMDGGOBGSA-N 0.000 claims 1
- BBNMGOAMHUSXPS-CSKARUKUSA-N (e)-3-[2-[2-(3,4-dihydro-2h-chromen-2-yl)ethoxy]-4-(imidazol-1-ylmethyl)phenyl]prop-2-enoic acid Chemical compound C1=C(OCCC2OC3=CC=CC=C3CC2)C(/C=C/C(=O)O)=CC=C1CN1C=CN=C1 BBNMGOAMHUSXPS-CSKARUKUSA-N 0.000 claims 1
- RUCOQAKDGFQSIK-BQYQJAHWSA-N (e)-3-[2-[2-(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)ethoxy]-4-(imidazol-1-ylmethyl)phenyl]prop-2-enoic acid Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)CCOC(C(=CC=1)\C=C\C(O)=O)=CC=1CN1C=CN=C1 RUCOQAKDGFQSIK-BQYQJAHWSA-N 0.000 claims 1
- CUSJRLUHZFGFSF-CMDGGOBGSA-N (e)-3-[2-[2-(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]prop-2-enoic acid Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)CCOC(C(=CC=1)\C=C\C(O)=O)=CC=1CN1C=CC=N1 CUSJRLUHZFGFSF-CMDGGOBGSA-N 0.000 claims 1
- FNAXIKJOZGKFOQ-BQYQJAHWSA-N (e)-3-[2-[2-(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)ethoxy]-4-(triazol-1-ylmethyl)phenyl]prop-2-enoic acid Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)CCOC(C(=CC=1)\C=C\C(O)=O)=CC=1CN1C=CN=N1 FNAXIKJOZGKFOQ-BQYQJAHWSA-N 0.000 claims 1
- AGBFXXLSTQJNBZ-BQYQJAHWSA-N (e)-3-[2-[2-(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)ethoxy]-4-(triazol-2-ylmethyl)phenyl]prop-2-enoic acid Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)CCOC(C(=CC=1)\C=C\C(O)=O)=CC=1CN1N=CC=N1 AGBFXXLSTQJNBZ-BQYQJAHWSA-N 0.000 claims 1
- SRRPBIDZWDYNEJ-CMDGGOBGSA-N (e)-3-[2-[2-(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)ethoxy]-4-[(2-methylimidazol-1-yl)methyl]phenyl]prop-2-enoic acid Chemical compound CC1=NC=CN1CC1=CC=C(\C=C\C(O)=O)C(OCCC2(C)OC3=C(C)C(C)=C(O)C(C)=C3CC2)=C1 SRRPBIDZWDYNEJ-CMDGGOBGSA-N 0.000 claims 1
- BAQYMRVJACKALV-ZHACJKMWSA-N (e)-3-[2-[2-[benzoyl(methyl)amino]ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(=O)N(C)CCOC(C(=CC=1)\C=C\C(O)=O)=CC=1CN1C=CC=N1 BAQYMRVJACKALV-ZHACJKMWSA-N 0.000 claims 1
- KCGWLEPLVIITSH-CCEZHUSRSA-N (e)-3-[2-[benzylsulfonyl(methyl)amino]-4-(phenoxymethyl)phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1CS(=O)(=O)N(C)C(C(=CC=1)\C=C\C(O)=O)=CC=1COC1=CC=CC=C1 KCGWLEPLVIITSH-CCEZHUSRSA-N 0.000 claims 1
- HXJKWCPFOADVNK-JLHYYAGUSA-N (e)-3-[2-[benzylsulfonyl(methyl)amino]-4-(pyrazol-1-ylmethyl)phenyl]-n-(3,4-difluorophenyl)sulfonylprop-2-enamide Chemical compound C=1C=CC=CC=1CS(=O)(=O)N(C)C(C(=CC=1)\C=C\C(=O)NS(=O)(=O)C=2C=C(F)C(F)=CC=2)=CC=1CN1C=CC=N1 HXJKWCPFOADVNK-JLHYYAGUSA-N 0.000 claims 1
- XYVVERQHWOIXCN-SAPNQHFASA-N (e)-3-[2-benzyl-4-(phenoxymethyl)phenyl]-n-(5-bromo-2-methoxyphenyl)sulfonylprop-2-enamide Chemical compound COC1=CC=C(Br)C=C1S(=O)(=O)NC(=O)\C=C\C(C(=C1)CC=2C=CC=CC=2)=CC=C1COC1=CC=CC=C1 XYVVERQHWOIXCN-SAPNQHFASA-N 0.000 claims 1
- HMGHCBANIJGKQE-BUHFOSPRSA-N (e)-3-[2-benzyl-4-(phenoxymethyl)phenyl]prop-2-enoic acid Chemical compound C1=C(CC=2C=CC=CC=2)C(/C=C/C(=O)O)=CC=C1COC1=CC=CC=C1 HMGHCBANIJGKQE-BUHFOSPRSA-N 0.000 claims 1
- KZJPCLIMFGEABU-JLHYYAGUSA-N (e)-3-[2-benzyl-4-(pyrazol-1-ylmethyl)phenyl]-n-(5-bromo-2-methoxyphenyl)sulfonylprop-2-enamide Chemical compound COC1=CC=C(Br)C=C1S(=O)(=O)NC(=O)\C=C\C(C(=C1)CC=2C=CC=CC=2)=CC=C1CN1N=CC=C1 KZJPCLIMFGEABU-JLHYYAGUSA-N 0.000 claims 1
- MDRIEONMZPTAOK-CMDGGOBGSA-N (e)-3-[3-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)thiophen-2-yl]prop-2-enoic acid Chemical compound C=1C=C2C=CC=CC2=CC=1CCOC1=C(/C=C/C(=O)O)SC=C1CN1C=CC=N1 MDRIEONMZPTAOK-CMDGGOBGSA-N 0.000 claims 1
- KCEIPWMLSPDTOL-CMDGGOBGSA-N (e)-3-[4-(2-naphthalen-2-ylethoxy)-5-(pyrazol-1-ylmethyl)thiophen-3-yl]prop-2-enoic acid Chemical compound C=1C=C2C=CC=CC2=CC=1CCOC=1C(/C=C/C(=O)O)=CSC=1CN1C=CC=N1 KCEIPWMLSPDTOL-CMDGGOBGSA-N 0.000 claims 1
- XOBFNKFQEVVBAB-FMIVXFBMSA-N (e)-3-[4-(cyanomethyl)-2-(2-naphthalen-2-ylethoxy)phenyl]-n-(3,4-difluorophenyl)sulfonylprop-2-enamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)\C=C\C1=CC=C(CC#N)C=C1OCCC1=CC=C(C=CC=C2)C2=C1 XOBFNKFQEVVBAB-FMIVXFBMSA-N 0.000 claims 1
- FUZPKGCVIAXTBU-MDZDMXLPSA-N (e)-3-[4-(cyanomethyl)-2-(2-naphthalen-2-ylethoxy)phenyl]prop-2-enoic acid Chemical compound OC(=O)\C=C\C1=CC=C(CC#N)C=C1OCCC1=CC=C(C=CC=C2)C2=C1 FUZPKGCVIAXTBU-MDZDMXLPSA-N 0.000 claims 1
- NREVODCYJWFTAE-BQYQJAHWSA-N (e)-3-[4-(hydroxymethyl)-2-[2-(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)ethoxy]phenyl]prop-2-enoic acid Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)CCOC1=CC(CO)=CC=C1\C=C\C(O)=O NREVODCYJWFTAE-BQYQJAHWSA-N 0.000 claims 1
- FWXQQZNZBVPPNL-OUKQBFOZSA-N (e)-3-[4-(imidazol-1-ylmethyl)-2-(6-phenoxyhexoxy)phenyl]prop-2-enoic acid Chemical compound C1=C(OCCCCCCOC=2C=CC=CC=2)C(/C=C/C(=O)O)=CC=C1CN1C=CN=C1 FWXQQZNZBVPPNL-OUKQBFOZSA-N 0.000 claims 1
- VRNLXRLGJZVWJP-BQYQJAHWSA-N (e)-3-[4-(imidazol-1-ylmethyl)-2-[2-(2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)ethoxy]phenyl]prop-2-enoic acid Chemical compound O1C2=C(C)C(C)=CC(C)=C2CCC1(C)CCOC(C(=CC=1)\C=C\C(O)=O)=CC=1CN1C=CN=C1 VRNLXRLGJZVWJP-BQYQJAHWSA-N 0.000 claims 1
- WIZUBUGGIFUGBL-CMDGGOBGSA-N (e)-3-[4-(imidazol-1-ylmethyl)-2-[2-(6-methoxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)ethoxy]phenyl]prop-2-enoic acid Chemical compound C1CC2=C(C)C(OC)=C(C)C(C)=C2OC1(C)CCOC(C(=CC=1)\C=C\C(O)=O)=CC=1CN1C=CN=C1 WIZUBUGGIFUGBL-CMDGGOBGSA-N 0.000 claims 1
- XFCQPMIQGQERNI-JLHYYAGUSA-N (e)-3-[4-[(4-acetylpiperazin-1-yl)methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]-n-(3,4-difluorophenyl)sulfonylprop-2-enamide Chemical compound C1CN(C(=O)C)CCN1CC(C=C1OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1\C=C\C(=O)NS(=O)(=O)C1=CC=C(F)C(F)=C1 XFCQPMIQGQERNI-JLHYYAGUSA-N 0.000 claims 1
- OLSLTEJRGBJPMB-VAWYXSNFSA-N (e)-3-[4-[(dimethylamino)methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]prop-2-enoic acid Chemical compound CN(C)CC1=CC=C(\C=C\C(O)=O)C(OCCC=2C=C3C=CC=CC3=CC=2)=C1 OLSLTEJRGBJPMB-VAWYXSNFSA-N 0.000 claims 1
- QGEXKIJAAGYWJU-FOCLMDBBSA-N (e)-3-[4-[(n-acetylanilino)methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]prop-2-enoic acid Chemical compound C=1C=C(\C=C\C(O)=O)C(OCCC=2C=C3C=CC=CC3=CC=2)=CC=1CN(C(=O)C)C1=CC=CC=C1 QGEXKIJAAGYWJU-FOCLMDBBSA-N 0.000 claims 1
- ACWYCOYYRWTEOY-FOCLMDBBSA-N (e)-3-[4-[(n-methylsulfonylanilino)methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]prop-2-enoic acid Chemical compound C=1C=C(\C=C\C(O)=O)C(OCCC=2C=C3C=CC=CC3=CC=2)=CC=1CN(S(=O)(=O)C)C1=CC=CC=C1 ACWYCOYYRWTEOY-FOCLMDBBSA-N 0.000 claims 1
- RRCNZWREZJNWLS-FOCLMDBBSA-N (e)-3-[4-[[benzoyl(methyl)amino]methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]prop-2-enoic acid Chemical compound C=1C=C(\C=C\C(O)=O)C(OCCC=2C=C3C=CC=CC3=CC=2)=CC=1CN(C)C(=O)C1=CC=CC=C1 RRCNZWREZJNWLS-FOCLMDBBSA-N 0.000 claims 1
- XBAKMNBJSNMAPW-SAPNQHFASA-N (e)-3-[4-benzyl-2-(2-naphthalen-2-ylethoxy)phenyl]-n-(3,4-difluorophenyl)sulfonylprop-2-enamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)\C=C\C(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CC1=CC=CC=C1 XBAKMNBJSNMAPW-SAPNQHFASA-N 0.000 claims 1
- WUSLPNBZMRDEEB-CCEZHUSRSA-N (e)-3-[4-benzyl-2-(2-naphthalen-2-ylethoxy)phenyl]prop-2-enoic acid Chemical compound C1=C(OCCC=2C=C3C=CC=CC3=CC=2)C(/C=C/C(=O)O)=CC=C1CC1=CC=CC=C1 WUSLPNBZMRDEEB-CCEZHUSRSA-N 0.000 claims 1
- DQHBDZQXMKXOEC-JLHYYAGUSA-N (e)-n-(3,4-difluorophenyl)sulfonyl-3-[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]prop-2-enamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)\C=C\C(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CN1N=CC=C1 DQHBDZQXMKXOEC-JLHYYAGUSA-N 0.000 claims 1
- NJGLOMGBJNRYST-FMIVXFBMSA-N (e)-n-(3,4-difluorophenyl)sulfonyl-3-[2-(2-naphthalen-2-ylethoxy)-4-(thiophen-3-ylmethyl)phenyl]prop-2-enamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)\C=C\C(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CC1=CSC=C1 NJGLOMGBJNRYST-FMIVXFBMSA-N 0.000 claims 1
- HLBREGNCTWIVFA-SDNWHVSQSA-N (e)-n-(3,4-difluorophenyl)sulfonyl-3-[2-(2-naphthalen-2-ylethoxy)-4-[(2-oxopyrrolidin-1-yl)methyl]phenyl]prop-2-enamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)\C=C\C(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CN1C(=O)CCC1 HLBREGNCTWIVFA-SDNWHVSQSA-N 0.000 claims 1
- NMJHGZVFEAHPCW-NTCAYCPXSA-N (e)-n-(3,4-difluorophenyl)sulfonyl-3-[2-(3-phenylpropyl)-4-(pyrazol-1-ylmethyl)phenyl]prop-2-enamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)\C=C\C(C(=C1)CCCC=2C=CC=CC=2)=CC=C1CN1N=CC=C1 NMJHGZVFEAHPCW-NTCAYCPXSA-N 0.000 claims 1
- YCIXXAWJXUOQMV-ZHACJKMWSA-N (e)-n-(3,4-difluorophenyl)sulfonyl-3-[3-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)thiophen-2-yl]prop-2-enamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)\C=C\C1=C(OCCC=2C=C3C=CC=CC3=CC=2)C(CN2N=CC=C2)=CS1 YCIXXAWJXUOQMV-ZHACJKMWSA-N 0.000 claims 1
- PKSJIDHRUIKSQR-OBGWFSINSA-N (e)-n-(5-bromo-2-methoxyphenyl)sulfonyl-3-[2-(naphthalen-2-ylmethyl)-4-(phenoxymethyl)phenyl]prop-2-enamide Chemical compound COC1=CC=C(Br)C=C1S(=O)(=O)NC(=O)\C=C\C(C(=C1)CC=2C=C3C=CC=CC3=CC=2)=CC=C1COC1=CC=CC=C1 PKSJIDHRUIKSQR-OBGWFSINSA-N 0.000 claims 1
- PCUGDZKVCLOZFS-SDNWHVSQSA-N (e)-n-(5-bromo-2-methoxyphenyl)sulfonyl-3-[2-(naphthalen-2-ylmethyl)-4-(pyrazol-1-ylmethyl)phenyl]prop-2-enamide Chemical compound COC1=CC=C(Br)C=C1S(=O)(=O)NC(=O)\C=C\C(C(=C1)CC=2C=C3C=CC=CC3=CC=2)=CC=C1CN1N=CC=C1 PCUGDZKVCLOZFS-SDNWHVSQSA-N 0.000 claims 1
- ACWGIYZEMLBIDO-FMQUCBEESA-N (e)-n-(benzenesulfonyl)-3-[2-(naphthalen-2-ylmethyl)-4-(phenoxymethyl)phenyl]prop-2-enamide Chemical compound C=1C=C(COC=2C=CC=CC=2)C=C(CC=2C=C3C=CC=CC3=CC=2)C=1/C=C/C(=O)NS(=O)(=O)C1=CC=CC=C1 ACWGIYZEMLBIDO-FMQUCBEESA-N 0.000 claims 1
- WMQGDDUHYMWHBP-FOCLMDBBSA-N (e)-n-(benzenesulfonyl)-3-[2-(naphthalen-2-ylmethyl)-4-(pyrazol-1-ylmethyl)phenyl]prop-2-enamide Chemical compound C=1C=C(CN2N=CC=C2)C=C(CC=2C=C3C=CC=CC3=CC=2)C=1/C=C/C(=O)NS(=O)(=O)C1=CC=CC=C1 WMQGDDUHYMWHBP-FOCLMDBBSA-N 0.000 claims 1
- CLOJZEZWXXXPAC-FOCLMDBBSA-N (e)-n-(benzenesulfonyl)-3-[2-[benzylsulfonyl(methyl)amino]-4-(pyrazol-1-ylmethyl)phenyl]prop-2-enamide Chemical compound C=1C=CC=CC=1CS(=O)(=O)N(C)C(C(=CC=1)\C=C\C(=O)NS(=O)(=O)C=2C=CC=CC=2)=CC=1CN1C=CC=N1 CLOJZEZWXXXPAC-FOCLMDBBSA-N 0.000 claims 1
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- NJWZTMVGBJROAJ-UHFFFAOYSA-N 2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)benzoic acid Chemical compound C1=C(OCCC=2C=C3C=CC=CC3=CC=2)C(C(=O)O)=CC=C1CN1C=CC=N1 NJWZTMVGBJROAJ-UHFFFAOYSA-N 0.000 claims 1
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- PDIGCRBAWRHHCI-QZQOTICOSA-N 2-[(e)-3-(benzenesulfonamido)-3-oxoprop-1-enyl]-n-(3-methyl-1-phenylbutyl)-5-(phenoxymethyl)benzamide Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)\C=C\C(=O)NS(=O)(=O)C=2C=CC=CC=2)=CC=1COC1=CC=CC=C1 PDIGCRBAWRHHCI-QZQOTICOSA-N 0.000 claims 1
- HHRMBRSJANWCJM-UHFFFAOYSA-N 2-[1-(2-naphthalen-1-ylpropanoyl)indol-3-yl]acetic acid Chemical compound C1=CC=C2C(C(C(=O)N3C4=CC=CC=C4C(CC(O)=O)=C3)C)=CC=CC2=C1 HHRMBRSJANWCJM-UHFFFAOYSA-N 0.000 claims 1
- MLHHOMJLGODXBA-UHFFFAOYSA-N 2-[1-benzyl-3-[(3-methyl-1-phenylbutyl)carbamoyl]indol-4-yl]acetic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C1=C(CC(O)=O)C=CC=C11)=CN1CC1=CC=CC=C1 MLHHOMJLGODXBA-UHFFFAOYSA-N 0.000 claims 1
- JUZWEMPFFFBUCL-UHFFFAOYSA-N 2-[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenoxy]acetic acid Chemical compound C1=C(OCCC=2C=C3C=CC=CC3=CC=2)C(OCC(=O)O)=CC=C1CN1C=CC=N1 JUZWEMPFFFBUCL-UHFFFAOYSA-N 0.000 claims 1
- GHVRDPIKQDTQNH-UHFFFAOYSA-N 2-[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]acetic acid Chemical compound C1=C(OCCC=2C=C3C=CC=CC3=CC=2)C(CC(=O)O)=CC=C1CN1C=CC=N1 GHVRDPIKQDTQNH-UHFFFAOYSA-N 0.000 claims 1
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- FPDJNJJOBYSLJL-UHFFFAOYSA-N 2-[2-(3-naphthalen-2-ylpropyl)-4-(pyrazol-1-ylmethyl)phenoxy]acetic acid Chemical compound C1=C(CCCC=2C=C3C=CC=CC3=CC=2)C(OCC(=O)O)=CC=C1CN1C=CC=N1 FPDJNJJOBYSLJL-UHFFFAOYSA-N 0.000 claims 1
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- AHMSBPYEAHQKMU-UHFFFAOYSA-N 2-[2-(naphthalen-2-ylmethyl)-3-oxo-5-(phenoxymethyl)-1h-isoindol-1-yl]acetic acid Chemical compound C=1C=C2C(CC(=O)O)N(CC=3C=C4C=CC=CC4=CC=3)C(=O)C2=CC=1COC1=CC=CC=C1 AHMSBPYEAHQKMU-UHFFFAOYSA-N 0.000 claims 1
- YDWHUMMREXLHIG-UHFFFAOYSA-N 2-[2-(naphthalen-2-ylmethyl)-3-oxo-5-(pyrazol-1-ylmethyl)-1h-isoindol-1-yl]acetic acid Chemical compound C=1C=C2C(CC(=O)O)N(CC=3C=C4C=CC=CC4=CC=3)C(=O)C2=CC=1CN1C=CC=N1 YDWHUMMREXLHIG-UHFFFAOYSA-N 0.000 claims 1
- RPUVBENUEXDESD-UHFFFAOYSA-N 2-[2-[(3-methyl-1-phenylbutyl)carbamoyl]-4-(phenoxymethyl)phenoxy]acetic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)OCC(O)=O)=CC=1COC1=CC=CC=C1 RPUVBENUEXDESD-UHFFFAOYSA-N 0.000 claims 1
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- NFGWBYHGPVUURT-UHFFFAOYSA-N 2-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenoxy]acetic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)OCC(O)=O)=CC=1COC1=CC=CC=C1 NFGWBYHGPVUURT-UHFFFAOYSA-N 0.000 claims 1
- INCFXZDKZAZMBU-UHFFFAOYSA-N 2-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-phenylmethoxyphenoxy]acetic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)OCC(O)=O)=CC=1OCC1=CC=CC=C1 INCFXZDKZAZMBU-UHFFFAOYSA-N 0.000 claims 1
- ZFFFCFHRRZXODT-UHFFFAOYSA-N 2-[2-methyl-1-(2-naphthalen-1-ylpropanoyl)indol-3-yl]acetic acid Chemical compound C1=CC=C2C(C(C(=O)N3C4=CC=CC=C4C(CC(O)=O)=C3C)C)=CC=CC2=C1 ZFFFCFHRRZXODT-UHFFFAOYSA-N 0.000 claims 1
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- DCPBZRXCYLMZMW-UHFFFAOYSA-N 2-[3-(benzenesulfonamido)-3-oxopropyl]-n-(3-methyl-1-phenylbutyl)-5-(pyrazol-1-ylmethyl)benzamide Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(=O)NS(=O)(=O)C=2C=CC=CC=2)=CC=1CN1C=CC=N1 DCPBZRXCYLMZMW-UHFFFAOYSA-N 0.000 claims 1
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- YCZKAYHICXGMIT-UHFFFAOYSA-N 2-[3-(benzenesulfonamido)-3-oxopropyl]-n-[1-(3,5-dimethoxyphenyl)-3-methylbutyl]-5-(pyrazol-1-ylmethyl)benzamide Chemical compound COC1=CC(OC)=CC(C(CC(C)C)NC(=O)C=2C(=CC=C(CN3N=CC=C3)C=2)CCC(=O)NS(=O)(=O)C=2C=CC=CC=2)=C1 YCZKAYHICXGMIT-UHFFFAOYSA-N 0.000 claims 1
- XLQIPEADHMRBOF-UHFFFAOYSA-N 2-[3-(benzenesulfonamido)-3-oxopropyl]-n-[1-(3,5-dimethylphenyl)-3-methylbutyl]-5-(pyrazol-1-ylmethyl)benzamide Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(=O)NS(=O)(=O)C=2C=CC=CC=2)=CC=1CN1C=CC=N1 XLQIPEADHMRBOF-UHFFFAOYSA-N 0.000 claims 1
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- CRZPLYPFNJWVIV-UHFFFAOYSA-N 2-[3-[(2,6-difluorophenyl)sulfonylamino]-3-oxopropyl]-n-[1-(4-fluorophenyl)-3-methylbutyl]-5-(phenoxymethyl)benzamide Chemical compound C=1C=C(F)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(=O)NS(=O)(=O)C=2C(=CC=CC=2F)F)=CC=1COC1=CC=CC=C1 CRZPLYPFNJWVIV-UHFFFAOYSA-N 0.000 claims 1
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- XWLGVQUGCZFUOW-UHFFFAOYSA-N 2-[3-[(3,4-difluorophenyl)sulfonylamino]-3-oxopropyl]-n-(naphthalen-1-ylmethyl)-5-(pyrazol-1-ylmethyl)benzamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)C(=O)NCC=2C3=CC=CC=C3C=CC=2)=CC=C1CN1N=CC=C1 XWLGVQUGCZFUOW-UHFFFAOYSA-N 0.000 claims 1
- DFJOIFVBIVWERI-UHFFFAOYSA-N 2-[3-[(3,4-difluorophenyl)sulfonylamino]-3-oxopropyl]-n-(naphthalen-2-ylmethyl)-5-(pyrazol-1-ylmethyl)benzamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)C(=O)NCC=2C=C3C=CC=CC3=CC=2)=CC=C1CN1N=CC=C1 DFJOIFVBIVWERI-UHFFFAOYSA-N 0.000 claims 1
- MSESDMMRRPJIEX-UHFFFAOYSA-N 2-[3-[(3,4-difluorophenyl)sulfonylamino]-3-oxopropyl]-n-[1-(3,5-dimethoxyphenyl)-3-methylbutyl]-5-(pyrazol-1-ylmethyl)benzamide Chemical compound COC1=CC(OC)=CC(C(CC(C)C)NC(=O)C=2C(=CC=C(CN3N=CC=C3)C=2)CCC(=O)NS(=O)(=O)C=2C=C(F)C(F)=CC=2)=C1 MSESDMMRRPJIEX-UHFFFAOYSA-N 0.000 claims 1
- SBFJRMXRUOFECZ-UHFFFAOYSA-N 2-[3-[(3,4-difluorophenyl)sulfonylamino]-3-oxopropyl]-n-[1-(3,5-dimethylphenyl)-3-methylbutyl]-5-(morpholin-4-ylmethyl)benzamide Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(=O)NS(=O)(=O)C=2C=C(F)C(F)=CC=2)=CC=1CN1CCOCC1 SBFJRMXRUOFECZ-UHFFFAOYSA-N 0.000 claims 1
- TZOXBMKVHJXENH-UHFFFAOYSA-N 2-[3-[(3,4-difluorophenyl)sulfonylamino]-3-oxopropyl]-n-[1-(3,5-dimethylphenyl)-3-methylbutyl]-5-(pyrazol-1-ylmethyl)benzamide Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(=O)NS(=O)(=O)C=2C=C(F)C(F)=CC=2)=CC=1CN1C=CC=N1 TZOXBMKVHJXENH-UHFFFAOYSA-N 0.000 claims 1
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- UBQQJQVCNJZAGN-UHFFFAOYSA-N 2-[3-[(3-cyanophenyl)sulfonylamino]-3-oxopropyl]-n-[1-(4-fluorophenyl)-3-methylbutyl]-5-(phenoxymethyl)benzamide Chemical compound C=1C=C(F)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(=O)NS(=O)(=O)C=2C=C(C=CC=2)C#N)=CC=1COC1=CC=CC=C1 UBQQJQVCNJZAGN-UHFFFAOYSA-N 0.000 claims 1
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- FZJCXUSOLSEALW-UHFFFAOYSA-N 2-[3-[(4-butoxyphenyl)sulfonylamino]-3-oxopropyl]-n-[1-(4-fluorophenyl)-3-methylbutyl]-5-(phenoxymethyl)benzamide Chemical compound C1=CC(OCCCC)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)C(=O)NC(CC(C)C)C=2C=CC(F)=CC=2)=CC=C1COC1=CC=CC=C1 FZJCXUSOLSEALW-UHFFFAOYSA-N 0.000 claims 1
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- ZZKQVVZXWIMWFS-UHFFFAOYSA-N 2-[3-[(4-cyanophenyl)sulfonylamino]-3-oxopropyl]-n-[1-(4-fluorophenyl)-3-methylbutyl]-5-(phenoxymethyl)benzamide Chemical compound C=1C=C(F)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(=O)NS(=O)(=O)C=2C=CC(=CC=2)C#N)=CC=1COC1=CC=CC=C1 ZZKQVVZXWIMWFS-UHFFFAOYSA-N 0.000 claims 1
- WANFHOVEEMLSTF-UHFFFAOYSA-N 2-[3-[(4-ethylphenyl)sulfonylamino]-3-oxopropyl]-n-[1-(4-fluorophenyl)-3-methylbutyl]-5-(phenoxymethyl)benzamide Chemical compound C1=CC(CC)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)C(=O)NC(CC(C)C)C=2C=CC(F)=CC=2)=CC=C1COC1=CC=CC=C1 WANFHOVEEMLSTF-UHFFFAOYSA-N 0.000 claims 1
- WMPMZXBEUQIJJS-UHFFFAOYSA-N 2-[3-[(5-bromo-2-methoxyphenyl)sulfonylamino]-3-oxopropyl]-n-(3-methyl-1-phenylbutyl)-5-(phenoxymethyl)benzamide Chemical compound COC1=CC=C(Br)C=C1S(=O)(=O)NC(=O)CCC(C(=C1)C(=O)NC(CC(C)C)C=2C=CC=CC=2)=CC=C1COC1=CC=CC=C1 WMPMZXBEUQIJJS-UHFFFAOYSA-N 0.000 claims 1
- AYVYTVWYSTXEAO-UHFFFAOYSA-N 2-[3-[[5-(benzamidomethyl)thiophen-2-yl]sulfonylamino]-3-oxopropyl]-n-[1-(4-fluorophenyl)-3-methylbutyl]-5-(phenoxymethyl)benzamide Chemical compound C=1C=C(F)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(=O)NS(=O)(=O)C=2SC(CNC(=O)C=3C=CC=CC=3)=CC=2)=CC=1COC1=CC=CC=C1 AYVYTVWYSTXEAO-UHFFFAOYSA-N 0.000 claims 1
- RWOPCBGYDYWWDD-UHFFFAOYSA-N 2-[3-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]-3-oxopropyl]-n-[1-(4-fluorophenyl)-3-methylbutyl]-5-(phenoxymethyl)benzamide Chemical compound C=1C=C(F)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(=O)NS(=O)(=O)C=2C3=CC=CC(=C3C=CC=2)N(C)C)=CC=1COC1=CC=CC=C1 RWOPCBGYDYWWDD-UHFFFAOYSA-N 0.000 claims 1
- WWJAWXADTOUHIR-UHFFFAOYSA-N 2-[4-[(2-chloro-6-fluorophenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenoxy]acetic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)OCC(O)=O)=CC=1OCC1=C(F)C=CC=C1Cl WWJAWXADTOUHIR-UHFFFAOYSA-N 0.000 claims 1
- GFBBHIGHTZLXIQ-UHFFFAOYSA-N 2-[4-[(2-methoxyphenoxy)methyl]-2-[(3-methyl-1-phenylbutyl)carbamoyl]phenoxy]acetic acid Chemical compound COC1=CC=CC=C1OCC1=CC=C(OCC(O)=O)C(C(=O)NC(CC(C)C)C=2C=CC=CC=2)=C1 GFBBHIGHTZLXIQ-UHFFFAOYSA-N 0.000 claims 1
- JCKQABMCHUHURK-UHFFFAOYSA-N 2-[4-[(2-methylphenoxy)methyl]-2-[(3-methyl-1-phenylbutyl)carbamoyl]phenoxy]acetic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)OCC(O)=O)=CC=1COC1=CC=CC=C1C JCKQABMCHUHURK-UHFFFAOYSA-N 0.000 claims 1
- BIYAQHWVRFSDJS-UHFFFAOYSA-N 2-[4-[(3-cyanophenoxy)methyl]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenoxy]acetic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)OCC(O)=O)=CC=1COC1=CC=CC(C#N)=C1 BIYAQHWVRFSDJS-UHFFFAOYSA-N 0.000 claims 1
- HLPHXQRZPJTQGJ-UHFFFAOYSA-N 2-[5-[(4-cyanophenoxy)methyl]-2-(naphthalen-2-ylmethyl)-3-oxo-1h-isoindol-1-yl]acetic acid Chemical compound C=1C=C2C(CC(=O)O)N(CC=3C=C4C=CC=CC4=CC=3)C(=O)C2=CC=1COC1=CC=C(C#N)C=C1 HLPHXQRZPJTQGJ-UHFFFAOYSA-N 0.000 claims 1
- PHXCHYYJVDCYEP-UHFFFAOYSA-N 2-[7-[(3-methyl-1-phenylbutyl)carbamoyl]-1h-indol-3-yl]acetic acid Chemical compound C=1C=CC=2C(CC(O)=O)=CNC=2C=1C(=O)NC(CC(C)C)C1=CC=CC=C1 PHXCHYYJVDCYEP-UHFFFAOYSA-N 0.000 claims 1
- LKZXPELYNJOYFG-UHFFFAOYSA-N 2-[7-[(3-methyl-1-phenylbutyl)carbamoyl]-2,3-dihydroindol-1-yl]acetic acid Chemical compound C=1C=CC=2CCN(CC(O)=O)C=2C=1C(=O)NC(CC(C)C)C1=CC=CC=C1 LKZXPELYNJOYFG-UHFFFAOYSA-N 0.000 claims 1
- SQARYQLJXKYBIW-UHFFFAOYSA-N 2-[7-[(3-methyl-1-phenylbutyl)carbamoyl]indol-1-yl]acetic acid Chemical compound C=1C=CC=2C=CN(CC(O)=O)C=2C=1C(=O)NC(CC(C)C)C1=CC=CC=C1 SQARYQLJXKYBIW-UHFFFAOYSA-N 0.000 claims 1
- SDOYVBSGTGNJCV-UHFFFAOYSA-N 2-[7-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-1-benzofuran-2-yl]acetic acid Chemical compound C=1C=CC=2C=C(CC(O)=O)OC=2C=1C(=O)NC(CC(C)C)C1=CC(C)=CC(C)=C1 SDOYVBSGTGNJCV-UHFFFAOYSA-N 0.000 claims 1
- LOWPLGIPGINIFW-UHFFFAOYSA-N 2-[7-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-2,3-dihydroindol-1-yl]acetic acid Chemical compound C=1C=CC=2CCN(CC(O)=O)C=2C=1C(=O)NC(CC(C)C)C1=CC(C)=CC(C)=C1 LOWPLGIPGINIFW-UHFFFAOYSA-N 0.000 claims 1
- YRUZSNYARHXOHW-UHFFFAOYSA-N 2-[8-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-3,4-dihydro-2h-quinolin-1-yl]acetic acid Chemical compound C=1C=CC=2CCCN(CC(O)=O)C=2C=1C(=O)NC(CC(C)C)C1=CC(C)=CC(C)=C1 YRUZSNYARHXOHW-UHFFFAOYSA-N 0.000 claims 1
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- SLFYHLKVQLZJTG-UHFFFAOYSA-N 2-[[2-(2-naphthalen-1-ylpropanoylamino)-4-(pyridin-3-yloxymethyl)phenyl]methyl]benzoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CC=2C(=CC=CC=2)C(O)=O)=CC=1COC1=CC=CN=C1 SLFYHLKVQLZJTG-UHFFFAOYSA-N 0.000 claims 1
- VXORVPMLFLWEFY-UHFFFAOYSA-N 2-[[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)benzoyl]amino]acetic acid Chemical compound C1=C(OCCC=2C=C3C=CC=CC3=CC=2)C(C(=O)NCC(=O)O)=CC=C1CN1C=CC=N1 VXORVPMLFLWEFY-UHFFFAOYSA-N 0.000 claims 1
- BHCJZNGDYXVVII-UHFFFAOYSA-N 2-[[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]methoxy]acetic acid Chemical compound C1=C(OCCC=2C=C3C=CC=CC3=CC=2)C(COCC(=O)O)=CC=C1CN1C=CC=N1 BHCJZNGDYXVVII-UHFFFAOYSA-N 0.000 claims 1
- GWYMPOSQAAYCEP-UHFFFAOYSA-N 2-[[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]methyl]benzoic acid Chemical compound OC(=O)C1=CC=CC=C1CC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CN1N=CC=C1 GWYMPOSQAAYCEP-UHFFFAOYSA-N 0.000 claims 1
- PNKRGDVBYIJGKW-UHFFFAOYSA-N 2-[[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]methylamino]acetic acid Chemical compound C1=C(OCCC=2C=C3C=CC=CC3=CC=2)C(CNCC(=O)O)=CC=C1CN1C=CC=N1 PNKRGDVBYIJGKW-UHFFFAOYSA-N 0.000 claims 1
- PVOZXQRBNBUHGL-UHFFFAOYSA-N 2-[[2-(2-phenylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]methyl]benzoic acid Chemical compound OC(=O)C1=CC=CC=C1CC(C(=C1)OCCC=2C=CC=CC=2)=CC=C1CN1N=CC=C1 PVOZXQRBNBUHGL-UHFFFAOYSA-N 0.000 claims 1
- GGZJSGKXOAMLNK-UHFFFAOYSA-N 2-[[2-(4-methyl-2-phenylpentoxy)-4-(pyrazol-1-ylmethyl)phenyl]methyl]benzoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)COC(C(=CC=1)CC=2C(=CC=CC=2)C(O)=O)=CC=1CN1C=CC=N1 GGZJSGKXOAMLNK-UHFFFAOYSA-N 0.000 claims 1
- PDCAPCPQVFLPQV-UHFFFAOYSA-N 2-[[2-[(2-naphthalen-1-ylacetyl)amino]-4-(phenoxymethyl)phenyl]methyl]benzoic acid Chemical compound OC(=O)C1=CC=CC=C1CC(C(=C1)NC(=O)CC=2C3=CC=CC=C3C=CC=2)=CC=C1COC1=CC=CC=C1 PDCAPCPQVFLPQV-UHFFFAOYSA-N 0.000 claims 1
- DAJATHUWKYAFNB-UHFFFAOYSA-N 2-[[2-[(3-methyl-1-phenylbutyl)carbamoyl]-4-(phenoxymethyl)phenyl]methoxy]acetic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)COCC(O)=O)=CC=1COC1=CC=CC=C1 DAJATHUWKYAFNB-UHFFFAOYSA-N 0.000 claims 1
- BBESWZILOPSLPV-UHFFFAOYSA-N 2-[[2-[(4-methyl-2-naphthalen-1-ylpentanoyl)amino]-4-(methylsulfonylmethyl)phenyl]methyl]benzoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(CC(C)C)C(=O)NC1=CC(CS(C)(=O)=O)=CC=C1CC1=CC=CC=C1C(O)=O BBESWZILOPSLPV-UHFFFAOYSA-N 0.000 claims 1
- OMDUHMNVGDSZOV-UHFFFAOYSA-N 2-[[2-[(4-methyl-2-naphthalen-1-ylpentanoyl)amino]-4-(phenoxymethyl)phenyl]methyl]benzoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(CC(C)C)C(=O)NC(C(=CC=1)CC=2C(=CC=CC=2)C(O)=O)=CC=1COC1=CC=CC=C1 OMDUHMNVGDSZOV-UHFFFAOYSA-N 0.000 claims 1
- WXTQSWUTEXDKIF-UHFFFAOYSA-N 2-[[2-[(4-methyl-2-naphthalen-1-ylpentanoyl)amino]-4-(pyrazol-1-ylmethyl)phenyl]methyl]benzoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(CC(C)C)C(=O)NC(C(=CC=1)CC=2C(=CC=CC=2)C(O)=O)=CC=1CN1C=CC=N1 WXTQSWUTEXDKIF-UHFFFAOYSA-N 0.000 claims 1
- WEIMZMHNIJUTDE-UHFFFAOYSA-N 2-[[2-[(4-methyl-2-naphthalen-1-ylpentanoyl)amino]-4-methylsulfonyloxyphenyl]methyl]benzoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(CC(C)C)C(=O)NC1=CC(OS(C)(=O)=O)=CC=C1CC1=CC=CC=C1C(O)=O WEIMZMHNIJUTDE-UHFFFAOYSA-N 0.000 claims 1
- HJJYJECVUUUJGP-UHFFFAOYSA-N 2-[[2-[(4-methyl-2-phenylpentanoyl)amino]-4-(phenoxymethyl)phenyl]methyl]benzoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)C(=O)NC(C(=CC=1)CC=2C(=CC=CC=2)C(O)=O)=CC=1COC1=CC=CC=C1 HJJYJECVUUUJGP-UHFFFAOYSA-N 0.000 claims 1
- BJHKXZGHKGOKHK-UHFFFAOYSA-N 2-[[2-[2-(3,5-dimethylphenyl)-4-methylpentoxy]-4-(pyrazol-1-ylmethyl)phenyl]methyl]benzoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)COC(C(=CC=1)CC=2C(=CC=CC=2)C(O)=O)=CC=1CN1C=CC=N1 BJHKXZGHKGOKHK-UHFFFAOYSA-N 0.000 claims 1
- XCLYWMFOIXTZGP-UHFFFAOYSA-N 2-[[2-[2-(4-fluoronaphthalen-1-yl)propanoylamino]-4-(phenoxymethyl)phenyl]methyl]benzoic acid Chemical compound C=1C=C(F)C2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CC=2C(=CC=CC=2)C(O)=O)=CC=1COC1=CC=CC=C1 XCLYWMFOIXTZGP-UHFFFAOYSA-N 0.000 claims 1
- RVYORWAPMLTYIL-UHFFFAOYSA-N 2-[[2-[[2-(3,5-dimethylphenyl)-4-methylpentanoyl]amino]-4-(phenoxymethyl)phenyl]methyl]benzoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)C(=O)NC(C(=CC=1)CC=2C(=CC=CC=2)C(O)=O)=CC=1COC1=CC=CC=C1 RVYORWAPMLTYIL-UHFFFAOYSA-N 0.000 claims 1
- JTUXLDCWMVCAKR-UHFFFAOYSA-N 2-[[2-[[2-(4-fluoronaphthalen-1-yl)acetyl]amino]-4-(phenoxymethyl)phenyl]methyl]benzoic acid Chemical compound OC(=O)C1=CC=CC=C1CC(C(=C1)NC(=O)CC=2C3=CC=CC=C3C(F)=CC=2)=CC=C1COC1=CC=CC=C1 JTUXLDCWMVCAKR-UHFFFAOYSA-N 0.000 claims 1
- KLAKXHLNKYHSTP-UHFFFAOYSA-N 2-[[4-(hydroxymethyl)-2-[(4-methyl-2-naphthalen-1-ylpentanoyl)amino]phenyl]methyl]benzoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(CC(C)C)C(=O)NC1=CC(CO)=CC=C1CC1=CC=CC=C1C(O)=O KLAKXHLNKYHSTP-UHFFFAOYSA-N 0.000 claims 1
- MKAQVHLCNJVHHF-UHFFFAOYSA-N 2-[[4-(methanesulfonamido)-2-[(4-methyl-2-naphthalen-1-ylpentanoyl)amino]phenyl]methyl]benzoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(CC(C)C)C(=O)NC1=CC(NS(C)(=O)=O)=CC=C1CC1=CC=CC=C1C(O)=O MKAQVHLCNJVHHF-UHFFFAOYSA-N 0.000 claims 1
- KZUWLMVGHSXMGP-UHFFFAOYSA-N 2-[[4-(methoxymethyl)-2-[(4-methyl-2-naphthalen-1-ylpentanoyl)amino]phenyl]methyl]benzoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(CC(C)C)C(=O)NC1=CC(COC)=CC=C1CC1=CC=CC=C1C(O)=O KZUWLMVGHSXMGP-UHFFFAOYSA-N 0.000 claims 1
- IVJPMRSJZUTJKM-UHFFFAOYSA-N 2-[[4-(phenoxymethyl)-2-(2-phenylpropanoylamino)phenyl]methyl]benzoic acid Chemical compound C=1C=CC=CC=1C(C)C(=O)NC(C(=CC=1)CC=2C(=CC=CC=2)C(O)=O)=CC=1COC1=CC=CC=C1 IVJPMRSJZUTJKM-UHFFFAOYSA-N 0.000 claims 1
- JTALYOPXXRAHLU-UHFFFAOYSA-N 2-[[4-[(2-chloro-5-methylphenoxy)methyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]methyl]benzoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CC=2C(=CC=CC=2)C(O)=O)=CC=1COC1=CC(C)=CC=C1Cl JTALYOPXXRAHLU-UHFFFAOYSA-N 0.000 claims 1
- LOIIXNBTYPMSNS-UHFFFAOYSA-N 2-[[4-[(2-methylphenoxy)methyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]methyl]benzoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CC=2C(=CC=CC=2)C(O)=O)=CC=1COC1=CC=CC=C1C LOIIXNBTYPMSNS-UHFFFAOYSA-N 0.000 claims 1
- MLYCQCWQLOWRSO-UHFFFAOYSA-N 2-[[4-[(3-cyanophenoxy)methyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]methyl]benzoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CC=2C(=CC=CC=2)C(O)=O)=CC=1COC1=CC=CC(C#N)=C1 MLYCQCWQLOWRSO-UHFFFAOYSA-N 0.000 claims 1
- VJXSKPUELCXCKJ-UHFFFAOYSA-N 2-[[4-[methyl(methylsulfonyl)amino]-2-[(4-methyl-2-naphthalen-1-ylpentanoyl)amino]phenyl]methyl]benzoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(CC(C)C)C(=O)NC1=CC(N(C)S(C)(=O)=O)=CC=C1CC1=CC=CC=C1C(O)=O VJXSKPUELCXCKJ-UHFFFAOYSA-N 0.000 claims 1
- AEGKDWVDVSBUTG-UHFFFAOYSA-N 2-[[4-acetamido-2-[(4-methyl-2-naphthalen-1-ylpentanoyl)amino]phenyl]methyl]benzoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(CC(C)C)C(=O)NC1=CC(NC(C)=O)=CC=C1CC1=CC=CC=C1C(O)=O AEGKDWVDVSBUTG-UHFFFAOYSA-N 0.000 claims 1
- KVPNIWRFWGOWNF-UHFFFAOYSA-N 2-[methyl-[[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]methyl]amino]acetic acid Chemical compound C1=C(OCCC=2C=C3C=CC=CC3=CC=2)C(CN(CC(O)=O)C)=CC=C1CN1C=CC=N1 KVPNIWRFWGOWNF-UHFFFAOYSA-N 0.000 claims 1
- UTQSTLMOQDXQLT-UHFFFAOYSA-N 2-[methylsulfonyl-[[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]methyl]amino]acetic acid Chemical compound C1=C(OCCC=2C=C3C=CC=CC3=CC=2)C(CN(CC(O)=O)S(=O)(=O)C)=CC=C1CN1C=CC=N1 UTQSTLMOQDXQLT-UHFFFAOYSA-N 0.000 claims 1
- LYGLYFUBLZCHCT-UHFFFAOYSA-N 2h-1,2,4-oxadiazole-5-thione Chemical compound SC1=NC=NO1 LYGLYFUBLZCHCT-UHFFFAOYSA-N 0.000 claims 1
- MUWGYZTVQXWMPQ-UHFFFAOYSA-N 3-[1-(2-naphthalen-1-ylpropanoyl)indol-3-yl]propanoic acid Chemical compound C1=CC=C2C(C(C(=O)N3C4=CC=CC=C4C(CCC(O)=O)=C3)C)=CC=CC2=C1 MUWGYZTVQXWMPQ-UHFFFAOYSA-N 0.000 claims 1
- PSTSROIGCKLJDY-UHFFFAOYSA-N 3-[1-[(3-cyanophenyl)methyl]-3-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]indol-4-yl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C1=C(CCC(O)=O)C=CC=C11)=CN1CC1=CC=CC(C#N)=C1 PSTSROIGCKLJDY-UHFFFAOYSA-N 0.000 claims 1
- KBXRTXYLRUULLE-UHFFFAOYSA-N 3-[1-benzyl-3-[(3-methyl-1-phenylbutyl)carbamoyl]indol-4-yl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C1=C(CCC(O)=O)C=CC=C11)=CN1CC1=CC=CC=C1 KBXRTXYLRUULLE-UHFFFAOYSA-N 0.000 claims 1
- QNADFUQYEPFRCC-UHFFFAOYSA-N 3-[1-benzyl-3-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]indol-4-yl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C1=C(CCC(O)=O)C=CC=C11)=CN1CC1=CC=CC=C1 QNADFUQYEPFRCC-UHFFFAOYSA-N 0.000 claims 1
- OSQJDOOBMAGXFO-UHFFFAOYSA-N 3-[2-(1-naphthalen-1-ylpropylcarbamoyl)-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(CC)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 OSQJDOOBMAGXFO-UHFFFAOYSA-N 0.000 claims 1
- YZEQVZIWPYQDOI-UHFFFAOYSA-N 3-[2-(1-naphthalen-2-ylethylcarbamoyl)-4-phenoxyphenyl]propanoic acid Chemical compound C=1C=C2C=CC=CC2=CC=1C(C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OC1=CC=CC=C1 YZEQVZIWPYQDOI-UHFFFAOYSA-N 0.000 claims 1
- WFNVWICDRIMRDI-UHFFFAOYSA-N 3-[2-(2-anilino-2-oxoethoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCC(=O)NC=2C=CC=CC=2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 WFNVWICDRIMRDI-UHFFFAOYSA-N 0.000 claims 1
- SLNIADDQDCUDSD-UHFFFAOYSA-N 3-[2-(2-anilinoethoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCCNC=2C=CC=CC=2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 SLNIADDQDCUDSD-UHFFFAOYSA-N 0.000 claims 1
- JBPFKJBUCHDKDU-UHFFFAOYSA-N 3-[2-(2-benzamido-4-methylpentoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(=O)NC(CC(C)C)COC(C(=CC=1)CCC(O)=O)=CC=1CN1C=CC=N1 JBPFKJBUCHDKDU-UHFFFAOYSA-N 0.000 claims 1
- BWTYUSBUZBQXCB-UHFFFAOYSA-N 3-[2-(2-benzamidoethoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCCNC(=O)C=2C=CC=CC=2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 BWTYUSBUZBQXCB-UHFFFAOYSA-N 0.000 claims 1
- BQDJXUKZSTYTQB-UHFFFAOYSA-N 3-[2-(2-carbazol-9-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCCN2C3=CC=CC=C3C3=CC=CC=C32)C(CCC(=O)O)=CC=C1CN1C=CC=N1 BQDJXUKZSTYTQB-UHFFFAOYSA-N 0.000 claims 1
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- IFKPGGJFDMCGEW-UHFFFAOYSA-N 3-[2-(5-phenylpentoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCCCCCC=2C=CC=CC=2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 IFKPGGJFDMCGEW-UHFFFAOYSA-N 0.000 claims 1
- XNCKVMQWUWOAFY-UHFFFAOYSA-N 3-[2-(5-phenylpentyl)-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(CCCCCC=2C=CC=CC=2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 XNCKVMQWUWOAFY-UHFFFAOYSA-N 0.000 claims 1
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- NQTJTVQCLHETBE-UHFFFAOYSA-N 3-[2-[(2-cyclopropyl-1-phenylethyl)carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C1=C(C(=O)NC(CC2CC2)C=2C=CC=CC=2)C(CCC(=O)O)=CC=C1COC1=CC=CC=C1 NQTJTVQCLHETBE-UHFFFAOYSA-N 0.000 claims 1
- KRXYJIFERNOADD-UHFFFAOYSA-N 3-[2-[(2-methoxy-2-phenylethyl)carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(OC)CNC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 KRXYJIFERNOADD-UHFFFAOYSA-N 0.000 claims 1
- XLEYZHTVSAIJHV-UHFFFAOYSA-N 3-[2-[(3-hydroxy-3-methyl-1-phenylbutyl)carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)(O)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 XLEYZHTVSAIJHV-UHFFFAOYSA-N 0.000 claims 1
- QIZFGKHZAGUMOI-UHFFFAOYSA-N 3-[2-[(3-methyl-1-naphthalen-1-ylbutyl)carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 QIZFGKHZAGUMOI-UHFFFAOYSA-N 0.000 claims 1
- SLBJXCBBAZEMCY-UHFFFAOYSA-N 3-[2-[(3-methyl-1-naphthalen-1-ylbutyl)carbamoyl]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1CN1C=CC=N1 SLBJXCBBAZEMCY-UHFFFAOYSA-N 0.000 claims 1
- NOADSQXSZQGXEL-UHFFFAOYSA-N 3-[2-[(3-methyl-1-naphthalen-1-ylbutyl)carbamoyl]-4-(pyridin-3-yloxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CN=C1 NOADSQXSZQGXEL-UHFFFAOYSA-N 0.000 claims 1
- GJJDYJNHQMALND-UHFFFAOYSA-N 3-[2-[(3-methyl-1-naphthalen-1-ylbutyl)carbamoyl]-4-phenoxyphenyl]propanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OC1=CC=CC=C1 GJJDYJNHQMALND-UHFFFAOYSA-N 0.000 claims 1
- ACKADIYQMIHUPO-UHFFFAOYSA-N 3-[2-[(3-methyl-1-phenylbutyl)carbamoyl]-4-(1,3-thiazol-2-ylsulfanylmethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1CSC1=NC=CS1 ACKADIYQMIHUPO-UHFFFAOYSA-N 0.000 claims 1
- WLKLHYDRXWHAKN-UHFFFAOYSA-N 3-[2-[(3-methyl-1-phenylbutyl)carbamoyl]-4-(1-phenoxyethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1C(C)OC1=CC=CC=C1 WLKLHYDRXWHAKN-UHFFFAOYSA-N 0.000 claims 1
- FEJQTCWTTKHYAA-UHFFFAOYSA-N 3-[2-[(3-methyl-1-phenylbutyl)carbamoyl]-4-(2-phenoxyethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1CCOC1=CC=CC=C1 FEJQTCWTTKHYAA-UHFFFAOYSA-N 0.000 claims 1
- UCTYTSZFMIQHCE-UHFFFAOYSA-N 3-[2-[(3-methyl-1-phenylbutyl)carbamoyl]-4-(2-phenylethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1CCC1=CC=CC=C1 UCTYTSZFMIQHCE-UHFFFAOYSA-N 0.000 claims 1
- HSHFSMZZWDOMPK-UHFFFAOYSA-N 3-[2-[(3-methyl-1-phenylbutyl)carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 HSHFSMZZWDOMPK-UHFFFAOYSA-N 0.000 claims 1
- GRNWLLAOYLZCNX-UHFFFAOYSA-N 3-[2-[(3-methyl-1-phenylbutyl)carbamoyl]-4-(phenylmethoxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COCC1=CC=CC=C1 GRNWLLAOYLZCNX-UHFFFAOYSA-N 0.000 claims 1
- GNANZLBSNRGXFA-UHFFFAOYSA-N 3-[2-[(3-methyl-1-phenylbutyl)carbamoyl]-4-(phenylsulfanylmethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1CSC1=CC=CC=C1 GNANZLBSNRGXFA-UHFFFAOYSA-N 0.000 claims 1
- JSVCEKQWZPFNHF-UHFFFAOYSA-N 3-[2-[(3-methyl-1-phenylbutyl)carbamoyl]-4-(pyrazin-2-yloxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CN=CC=N1 JSVCEKQWZPFNHF-UHFFFAOYSA-N 0.000 claims 1
- XLVQXHBJLLDIHP-UHFFFAOYSA-N 3-[2-[(3-methyl-1-phenylbutyl)carbamoyl]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1CN1C=CC=N1 XLVQXHBJLLDIHP-UHFFFAOYSA-N 0.000 claims 1
- QHPCHAOVJYAJBG-UHFFFAOYSA-N 3-[2-[(3-methyl-1-phenylbutyl)carbamoyl]-4-(pyridin-2-yloxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=N1 QHPCHAOVJYAJBG-UHFFFAOYSA-N 0.000 claims 1
- VUJHYQCPWQWGHE-UHFFFAOYSA-N 3-[2-[(3-methyl-1-phenylbutyl)carbamoyl]-4-(pyridin-3-yloxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CN=C1 VUJHYQCPWQWGHE-UHFFFAOYSA-N 0.000 claims 1
- XGMWFTWTWPBFMZ-UHFFFAOYSA-N 3-[2-[(3-methyl-1-phenylbutyl)carbamoyl]-4-(pyridin-4-yloxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=NC=C1 XGMWFTWTWPBFMZ-UHFFFAOYSA-N 0.000 claims 1
- KXGDRCSLPINIEE-UHFFFAOYSA-N 3-[2-[(3-methyl-1-phenylbutyl)carbamoyl]-4-(pyrimidin-2-yloxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=NC=CC=N1 KXGDRCSLPINIEE-UHFFFAOYSA-N 0.000 claims 1
- UAYYHNQCGYZLAU-UHFFFAOYSA-N 3-[2-[(3-methyl-1-phenylbutyl)carbamoyl]-4-[(2-methylpyridin-3-yl)oxymethyl]phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CN=C1C UAYYHNQCGYZLAU-UHFFFAOYSA-N 0.000 claims 1
- GCOQVBSRJXDZCT-UHFFFAOYSA-N 3-[2-[(3-methyl-1-phenylbutyl)carbamoyl]-4-methylsulfonyloxyphenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C1=CC(OS(C)(=O)=O)=CC=C1CCC(O)=O GCOQVBSRJXDZCT-UHFFFAOYSA-N 0.000 claims 1
- HEVAOXZPYXKZPP-UHFFFAOYSA-N 3-[2-[(3-methyl-1-phenylbutyl)carbamoyl]-4-phenylmethoxyphenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=CC=C1 HEVAOXZPYXKZPP-UHFFFAOYSA-N 0.000 claims 1
- SXTWFDBCKSPVOX-UHFFFAOYSA-N 3-[2-[(3-methyl-1-phenylbutyl)carbamoyl]-4-propan-2-ylsulfonyloxyphenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C1=CC(OS(=O)(=O)C(C)C)=CC=C1CCC(O)=O SXTWFDBCKSPVOX-UHFFFAOYSA-N 0.000 claims 1
- SPIMBIBITSUVIT-UHFFFAOYSA-N 3-[2-[(3-methyl-1-phenylbutyl)sulfamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NS(=O)(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 SPIMBIBITSUVIT-UHFFFAOYSA-N 0.000 claims 1
- UJNIRYZIZVESPG-UHFFFAOYSA-N 3-[2-[(3-methyl-1-thiophen-2-ylbutyl)carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=CSC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 UJNIRYZIZVESPG-UHFFFAOYSA-N 0.000 claims 1
- HSGYFYQTBPHEPP-UHFFFAOYSA-N 3-[2-[(3-methyl-1-thiophen-3-ylbutyl)carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C1=CSC=C1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 HSGYFYQTBPHEPP-UHFFFAOYSA-N 0.000 claims 1
- ONHZOILOJYDTFF-UHFFFAOYSA-N 3-[2-[(4-fluoronaphthalen-1-yl)methylcarbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C1=C(C(=O)NCC=2C3=CC=CC=C3C(F)=CC=2)C(CCC(=O)O)=CC=C1COC1=CC=CC=C1 ONHZOILOJYDTFF-UHFFFAOYSA-N 0.000 claims 1
- WRIYVYUDHQNPOV-UHFFFAOYSA-N 3-[2-[(4-methoxynaphthalen-1-yl)methylcarbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C12=CC=CC=C2C(OC)=CC=C1CNC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 WRIYVYUDHQNPOV-UHFFFAOYSA-N 0.000 claims 1
- XOACQTOEVJGFFE-UHFFFAOYSA-N 3-[2-[(4-methyl-1-phenylpentan-2-yl)carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C(COC=2C=CC=CC=2)=CC=C(CCC(O)=O)C=1C(=O)NC(CC(C)C)CC1=CC=CC=C1 XOACQTOEVJGFFE-UHFFFAOYSA-N 0.000 claims 1
- BNSSKXLVHGORSB-UHFFFAOYSA-N 3-[2-[(4-methyl-2-naphthalen-1-ylpentanoyl)amino]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(CC(C)C)C(=O)NC(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 BNSSKXLVHGORSB-UHFFFAOYSA-N 0.000 claims 1
- LHDJVOXXIXZQEG-UHFFFAOYSA-N 3-[2-[(4-methyl-2-phenylpentanoyl)amino]-4-phenoxyphenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)C(=O)NC(C(=CC=1)CCC(O)=O)=CC=1OC1=CC=CC=C1 LHDJVOXXIXZQEG-UHFFFAOYSA-N 0.000 claims 1
- KTPLHLHZWFTGNV-UHFFFAOYSA-N 3-[2-[(4-methyl-2-phenylpentyl)carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)CNC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 KTPLHLHZWFTGNV-UHFFFAOYSA-N 0.000 claims 1
- DMWYQDPWIUHXGL-UHFFFAOYSA-N 3-[2-[(4-naphthalen-1-yloxan-4-yl)carbamoyl]-4-phenoxyphenyl]propanoic acid Chemical compound C1=C(C(=O)NC2(CCOCC2)C=2C3=CC=CC=C3C=CC=2)C(CCC(=O)O)=CC=C1OC1=CC=CC=C1 DMWYQDPWIUHXGL-UHFFFAOYSA-N 0.000 claims 1
- IUGPZZNURHHDFY-UHFFFAOYSA-N 3-[2-[(naphthalene-2-carbonylamino)methyl]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(CNC(=O)C=2C=C3C=CC=CC3=CC=2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 IUGPZZNURHHDFY-UHFFFAOYSA-N 0.000 claims 1
- BQFGPVRXAYQNJL-UHFFFAOYSA-N 3-[2-[1-(4-fluorophenyl)ethylcarbamoyl]-4-phenoxyphenyl]propanoic acid Chemical compound C=1C=C(F)C=CC=1C(C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OC1=CC=CC=C1 BQFGPVRXAYQNJL-UHFFFAOYSA-N 0.000 claims 1
- ZEBDLBWUKHCEAD-UHFFFAOYSA-N 3-[2-[2-(1-benzofuran-2-yl)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCCC=2OC3=CC=CC=C3C=2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 ZEBDLBWUKHCEAD-UHFFFAOYSA-N 0.000 claims 1
- NXHSVFYJNXNULX-UHFFFAOYSA-N 3-[2-[2-(1-benzothiophen-2-yl)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCCC=2SC3=CC=CC=C3C=2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 NXHSVFYJNXNULX-UHFFFAOYSA-N 0.000 claims 1
- YHKFOFSPBMTEQL-UHFFFAOYSA-N 3-[2-[2-(1-benzothiophen-3-yl)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCCC=2C3=CC=CC=C3SC=2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 YHKFOFSPBMTEQL-UHFFFAOYSA-N 0.000 claims 1
- CKBICMZLBPAOIP-UHFFFAOYSA-N 3-[2-[2-(1-methylindol-2-yl)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C=1C2=CC=CC=C2N(C)C=1CCOC(C(=CC=1)CCC(O)=O)=CC=1CN1C=CC=N1 CKBICMZLBPAOIP-UHFFFAOYSA-N 0.000 claims 1
- DOSINWAEMZTSNC-UHFFFAOYSA-N 3-[2-[2-(1-methylindol-3-yl)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C12=CC=CC=C2N(C)C=C1CCOC(C(=CC=1)CCC(O)=O)=CC=1CN1C=CC=N1 DOSINWAEMZTSNC-UHFFFAOYSA-N 0.000 claims 1
- PSROAZHDVIFHHA-UHFFFAOYSA-N 3-[2-[2-(2-methylbenzimidazol-1-yl)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound CC1=NC2=CC=CC=C2N1CCOC(C(=CC=1)CCC(O)=O)=CC=1CN1C=CC=N1 PSROAZHDVIFHHA-UHFFFAOYSA-N 0.000 claims 1
- RXOPOUQKTICFBY-UHFFFAOYSA-N 3-[2-[2-(2-methylimidazol-1-yl)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound CC1=NC=CN1CCOC1=CC(CN2N=CC=C2)=CC=C1CCC(O)=O RXOPOUQKTICFBY-UHFFFAOYSA-N 0.000 claims 1
- SMUJNXDTDGGBGW-UHFFFAOYSA-N 3-[2-[2-(3,4-dihydro-2h-chromen-2-yl)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCCC2OC3=CC=CC=C3CC2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 SMUJNXDTDGGBGW-UHFFFAOYSA-N 0.000 claims 1
- PDPZTPZDZVOMCK-UHFFFAOYSA-N 3-[2-[2-(3,5-dimethylphenyl)-4-methylpentoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)COC(C(=CC=1)CCC(O)=O)=CC=1CN1C=CC=N1 PDPZTPZDZVOMCK-UHFFFAOYSA-N 0.000 claims 1
- SOOFWZLNWOHJOC-UHFFFAOYSA-N 3-[2-[2-(3-morpholin-4-ylphenyl)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCCC=2C=C(C=CC=2)N2CCOCC2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 SOOFWZLNWOHJOC-UHFFFAOYSA-N 0.000 claims 1
- SZVSGHGCMKUXPQ-UHFFFAOYSA-N 3-[2-[2-(3-phenylphenyl)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCCC=2C=C(C=CC=2)C=2C=CC=CC=2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 SZVSGHGCMKUXPQ-UHFFFAOYSA-N 0.000 claims 1
- XGUFAKDKYBCWJN-UHFFFAOYSA-N 3-[2-[2-(3-piperidin-1-ylphenyl)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCCC=2C=C(C=CC=2)N2CCCCC2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 XGUFAKDKYBCWJN-UHFFFAOYSA-N 0.000 claims 1
- ZYHWHBZLJWYPIN-UHFFFAOYSA-N 3-[2-[2-(4-fluoro-3-methylphenyl)-4-methylpentoxy]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(F)C(C)=CC=1C(CC(C)C)COC(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 ZYHWHBZLJWYPIN-UHFFFAOYSA-N 0.000 claims 1
- IQNBRDUHHUWQEK-UHFFFAOYSA-N 3-[2-[2-(4-fluoro-3-methylphenyl)-4-methylpentoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C=1C=C(F)C(C)=CC=1C(CC(C)C)COC(C(=CC=1)CCC(O)=O)=CC=1CN1C=CC=N1 IQNBRDUHHUWQEK-UHFFFAOYSA-N 0.000 claims 1
- PDHJFCFVRHATKK-UHFFFAOYSA-N 3-[2-[2-(4-fluoronaphthalen-1-yl)propanoylamino]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(F)C2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 PDHJFCFVRHATKK-UHFFFAOYSA-N 0.000 claims 1
- FEUSGLSVJPLTDT-UHFFFAOYSA-N 3-[2-[2-(4-phenyl-3,6-dihydro-2h-pyridin-1-yl)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCCN2CC=C(CC2)C=2C=CC=CC=2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 FEUSGLSVJPLTDT-UHFFFAOYSA-N 0.000 claims 1
- YYTVDXWROQVAJD-UHFFFAOYSA-N 3-[2-[2-(4-phenylphenyl)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCCC=2C=CC(=CC=2)C=2C=CC=CC=2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 YYTVDXWROQVAJD-UHFFFAOYSA-N 0.000 claims 1
- OVEXJDLHAPWJRU-UHFFFAOYSA-N 3-[2-[2-(4-phenylpiperazin-1-yl)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCCN2CCN(CC2)C=2C=CC=CC=2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 OVEXJDLHAPWJRU-UHFFFAOYSA-N 0.000 claims 1
- UCNOJVQHAZDPSJ-UHFFFAOYSA-N 3-[2-[2-(4-phenylpiperidin-1-yl)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCCN2CCC(CC2)C=2C=CC=CC=2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 UCNOJVQHAZDPSJ-UHFFFAOYSA-N 0.000 claims 1
- UQASBIJQVUQIRE-UHFFFAOYSA-N 3-[2-[2-(6-methoxynaphthalen-2-yl)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=CC2=CC(OC)=CC=C2C=C1CCOC(C(=CC=1)CCC(O)=O)=CC=1CN1C=CC=N1 UQASBIJQVUQIRE-UHFFFAOYSA-N 0.000 claims 1
- CHXHSBYJZRBQPN-UHFFFAOYSA-N 3-[2-[2-(7-methoxy-1,3-benzodioxol-5-yl)-4-methylpentoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C=1C=2OCOC=2C(OC)=CC=1C(CC(C)C)COC(C(=CC=1)CCC(O)=O)=CC=1CN1C=CC=N1 CHXHSBYJZRBQPN-UHFFFAOYSA-N 0.000 claims 1
- DQQMZAYUPLMLDM-UHFFFAOYSA-N 3-[2-[2-(9-methylcarbazol-2-yl)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C2N(C)C3=CC=CC=C3C2=CC=C1CCOC(C(=CC=1)CCC(O)=O)=CC=1CN1C=CC=N1 DQQMZAYUPLMLDM-UHFFFAOYSA-N 0.000 claims 1
- OTTZAJJZOSQSTP-UHFFFAOYSA-N 3-[2-[2-(9-oxoacridin-10-yl)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCCN2C3=CC=CC=C3C(=O)C3=CC=CC=C32)C(CCC(=O)O)=CC=C1CN1C=CC=N1 OTTZAJJZOSQSTP-UHFFFAOYSA-N 0.000 claims 1
- XZUSTJKLTFWGQW-UHFFFAOYSA-N 3-[2-[2-(benzenesulfonamido)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCCNS(=O)(=O)C=2C=CC=CC=2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 XZUSTJKLTFWGQW-UHFFFAOYSA-N 0.000 claims 1
- AJNKSEPLIGPFCT-UHFFFAOYSA-N 3-[2-[2-(benzimidazol-1-yl)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]-n-(3,4-difluorophenyl)sulfonylpropanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCN2C3=CC=CC=C3N=C2)=CC=C1CN1N=CC=C1 AJNKSEPLIGPFCT-UHFFFAOYSA-N 0.000 claims 1
- HGDKJGDWJDXTDM-UHFFFAOYSA-N 3-[2-[2-(benzimidazol-1-yl)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCCN2C3=CC=CC=C3N=C2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 HGDKJGDWJDXTDM-UHFFFAOYSA-N 0.000 claims 1
- YIQZOESMDJOXJN-UHFFFAOYSA-N 3-[2-[2-(benzotriazol-1-yl)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]-n-(3,4-difluorophenyl)sulfonylpropanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCN2C3=CC=CC=C3N=N2)=CC=C1CN1N=CC=C1 YIQZOESMDJOXJN-UHFFFAOYSA-N 0.000 claims 1
- UYZAIZPZMHBUFN-UHFFFAOYSA-N 3-[2-[2-(benzotriazol-1-yl)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCCN2C3=CC=CC=C3N=N2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 UYZAIZPZMHBUFN-UHFFFAOYSA-N 0.000 claims 1
- USQJPMVIUXFHSF-UHFFFAOYSA-N 3-[2-[2-(benzotriazol-2-yl)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]-n-(3,4-difluorophenyl)sulfonylpropanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCN2N=C3C=CC=CC3=N2)=CC=C1CN1N=CC=C1 USQJPMVIUXFHSF-UHFFFAOYSA-N 0.000 claims 1
- GDSBJDXLMVWXJN-UHFFFAOYSA-N 3-[2-[2-(benzotriazol-2-yl)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCCN2N=C3C=CC=CC3=N2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 GDSBJDXLMVWXJN-UHFFFAOYSA-N 0.000 claims 1
- HOLJPAFKMUMYEX-UHFFFAOYSA-N 3-[2-[2-(benzylamino)-2-oxoethoxy]-4-(pyrazol-1-ylmethyl)phenyl]-n-(3,4-difluorophenyl)sulfonylpropanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCC(=O)NCC=2C=CC=CC=2)=CC=C1CN1N=CC=C1 HOLJPAFKMUMYEX-UHFFFAOYSA-N 0.000 claims 1
- XLCQRGXIHVPXSI-UHFFFAOYSA-N 3-[2-[2-(benzylamino)-2-oxoethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCC(=O)NCC=2C=CC=CC=2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 XLCQRGXIHVPXSI-UHFFFAOYSA-N 0.000 claims 1
- WSLXRDIRROMXTI-UHFFFAOYSA-N 3-[2-[2-(n-acetylanilino)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1N(C(=O)C)CCOC(C(=CC=1)CCC(O)=O)=CC=1CN1C=CC=N1 WSLXRDIRROMXTI-UHFFFAOYSA-N 0.000 claims 1
- MQEOCYCUYIGVIS-UHFFFAOYSA-N 3-[2-[2-(n-benzylanilino)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCCN(CC=2C=CC=CC=2)C=2C=CC=CC=2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 MQEOCYCUYIGVIS-UHFFFAOYSA-N 0.000 claims 1
- RPYQWTDIFLJFTG-UHFFFAOYSA-N 3-[2-[2-(n-ethylanilino)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1N(CC)CCOC(C(=CC=1)CCC(O)=O)=CC=1CN1C=CC=N1 RPYQWTDIFLJFTG-UHFFFAOYSA-N 0.000 claims 1
- VBYLOCHKWYDPHY-UHFFFAOYSA-N 3-[2-[2-(n-methylanilino)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1N(C)CCOC(C(=CC=1)CCC(O)=O)=CC=1CN1C=CC=N1 VBYLOCHKWYDPHY-UHFFFAOYSA-N 0.000 claims 1
- CYUMSQCDIJEXPG-UHFFFAOYSA-N 3-[2-[2-(n-methylsulfonylanilino)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1N(S(=O)(=O)C)CCOC(C(=CC=1)CCC(O)=O)=CC=1CN1C=CC=N1 CYUMSQCDIJEXPG-UHFFFAOYSA-N 0.000 claims 1
- LNIQYEUEWHILNO-UHFFFAOYSA-N 3-[2-[2-(n-phenylanilino)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCCN(C=2C=CC=CC=2)C=2C=CC=CC=2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 LNIQYEUEWHILNO-UHFFFAOYSA-N 0.000 claims 1
- PDKONRJOMOJCEG-UHFFFAOYSA-N 3-[2-[2-(n-propylanilino)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1N(CCC)CCOC(C(=CC=1)CCC(O)=O)=CC=1CN1C=CC=N1 PDKONRJOMOJCEG-UHFFFAOYSA-N 0.000 claims 1
- BILMUHWIYCFYKM-UHFFFAOYSA-N 3-[2-[2-(naphthalen-1-ylamino)-2-oxoethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCC(=O)NC=2C3=CC=CC=C3C=CC=2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 BILMUHWIYCFYKM-UHFFFAOYSA-N 0.000 claims 1
- YPZHKFYAUMHYOZ-UHFFFAOYSA-N 3-[2-[2-(naphthalen-2-ylamino)-2-oxoethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCC(=O)NC=2C=C3C=CC=CC3=CC=2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 YPZHKFYAUMHYOZ-UHFFFAOYSA-N 0.000 claims 1
- UDRRIDGVWARRND-UHFFFAOYSA-N 3-[2-[2-(naphthalene-1-carbonylamino)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCCNC(=O)C=2C3=CC=CC=C3C=CC=2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 UDRRIDGVWARRND-UHFFFAOYSA-N 0.000 claims 1
- BESLNLIZDILHDT-UHFFFAOYSA-N 3-[2-[2-(naphthalene-2-carbonylamino)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCCNC(=O)C=2C=C3C=CC=CC3=CC=2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 BESLNLIZDILHDT-UHFFFAOYSA-N 0.000 claims 1
- RDMMHNXALMBJFL-UHFFFAOYSA-N 3-[2-[2-[(2-chlorobenzoyl)amino]ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCCNC(=O)C=2C(=CC=CC=2)Cl)C(CCC(=O)O)=CC=C1CN1C=CC=N1 RDMMHNXALMBJFL-UHFFFAOYSA-N 0.000 claims 1
- XXOMUQVPBYOANL-UHFFFAOYSA-N 3-[2-[2-[(2-methoxybenzoyl)amino]ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound COC1=CC=CC=C1C(=O)NCCOC1=CC(CN2N=CC=C2)=CC=C1CCC(O)=O XXOMUQVPBYOANL-UHFFFAOYSA-N 0.000 claims 1
- ONONIEJAKVOWGW-UHFFFAOYSA-N 3-[2-[2-[(2-methylbenzoyl)amino]ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound CC1=CC=CC=C1C(=O)NCCOC1=CC(CN2N=CC=C2)=CC=C1CCC(O)=O ONONIEJAKVOWGW-UHFFFAOYSA-N 0.000 claims 1
- YATIVYZJCZNACA-UHFFFAOYSA-N 3-[2-[2-[(3-chlorobenzoyl)amino]ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCCNC(=O)C=2C=C(Cl)C=CC=2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 YATIVYZJCZNACA-UHFFFAOYSA-N 0.000 claims 1
- RQYPQLNSYBKCGU-UHFFFAOYSA-N 3-[2-[2-[(3-methylbenzoyl)amino]ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound CC1=CC=CC(C(=O)NCCOC=2C(=CC=C(CN3N=CC=C3)C=2)CCC(O)=O)=C1 RQYPQLNSYBKCGU-UHFFFAOYSA-N 0.000 claims 1
- MMCKELNXRFZTRT-UHFFFAOYSA-N 3-[2-[2-[(4-chlorobenzoyl)amino]ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCCNC(=O)C=2C=CC(Cl)=CC=2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 MMCKELNXRFZTRT-UHFFFAOYSA-N 0.000 claims 1
- CTPXPILTKPPZTM-UHFFFAOYSA-N 3-[2-[2-[(4-methoxybenzoyl)amino]ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=CC(OC)=CC=C1C(=O)NCCOC1=CC(CN2N=CC=C2)=CC=C1CCC(O)=O CTPXPILTKPPZTM-UHFFFAOYSA-N 0.000 claims 1
- LSMBDDVLMHBAOM-UHFFFAOYSA-N 3-[2-[2-[(4-methylbenzoyl)amino]ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=CC(C)=CC=C1C(=O)NCCOC1=CC(CN2N=CC=C2)=CC=C1CCC(O)=O LSMBDDVLMHBAOM-UHFFFAOYSA-N 0.000 claims 1
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- LIWHBQNMTVOPDU-UHFFFAOYSA-N 3-[2-[2-[3-(4-methylpiperazin-1-yl)phenyl]ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1CN(C)CCN1C1=CC=CC(CCOC=2C(=CC=C(CN3N=CC=C3)C=2)CCC(O)=O)=C1 LIWHBQNMTVOPDU-UHFFFAOYSA-N 0.000 claims 1
- OWRGKJQMCRATNP-UHFFFAOYSA-N 3-[2-[2-[benzenesulfonyl(methyl)amino]ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1S(=O)(=O)N(C)CCOC(C(=CC=1)CCC(O)=O)=CC=1CN1C=CC=N1 OWRGKJQMCRATNP-UHFFFAOYSA-N 0.000 claims 1
- YPKBBTBTXHRLKO-UHFFFAOYSA-N 3-[2-[2-[benzyl(ethyl)amino]ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1CN(CC)CCOC(C(=CC=1)CCC(O)=O)=CC=1CN1C=CC=N1 YPKBBTBTXHRLKO-UHFFFAOYSA-N 0.000 claims 1
- ZXEZDIGMTIDQKY-UHFFFAOYSA-N 3-[2-[2-[benzyl(methyl)amino]ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1CN(C)CCOC(C(=CC=1)CCC(O)=O)=CC=1CN1C=CC=N1 ZXEZDIGMTIDQKY-UHFFFAOYSA-N 0.000 claims 1
- IXQSPYHREOXLGU-UHFFFAOYSA-N 3-[2-[2-[n-(2-cyanoethyl)anilino]ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCCN(CCC#N)C=2C=CC=CC=2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 IXQSPYHREOXLGU-UHFFFAOYSA-N 0.000 claims 1
- VYRCGNYAGOHEKZ-UHFFFAOYSA-N 3-[2-[2-[n-(2-hydroxyethyl)anilino]ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1N(CCO)CCOC(C(=CC=1)CCC(O)=O)=CC=1CN1C=CC=N1 VYRCGNYAGOHEKZ-UHFFFAOYSA-N 0.000 claims 1
- QIIPDILGFCAJKZ-UHFFFAOYSA-N 3-[2-[2-oxo-2-(1-phenylethylamino)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(C)NC(=O)COC(C(=CC=1)CCC(O)=O)=CC=1CN1C=CC=N1 QIIPDILGFCAJKZ-UHFFFAOYSA-N 0.000 claims 1
- NGJXJJQUATVWFZ-UHFFFAOYSA-N 3-[2-[3-(n-methylanilino)propoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1N(C)CCCOC(C(=CC=1)CCC(O)=O)=CC=1CN1C=CC=N1 NGJXJJQUATVWFZ-UHFFFAOYSA-N 0.000 claims 1
- DMIVKACESZUVJS-OLVCOQPYSA-N 3-[2-[[(1r)-1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-(3-methoxyphenoxy)phenyl]butanoic acid Chemical compound COC1=CC=CC(OC=2C=C(C(C(C)CC(O)=O)=CC=2)C(=O)N[C@H](CC(C)C)C=2C=C(C)C=C(C)C=2)=C1 DMIVKACESZUVJS-OLVCOQPYSA-N 0.000 claims 1
- ALKDPZDQOKEMAM-MUUNZHRXSA-N 3-[2-[[(1r)-1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound N([C@H](CC(C)C)C=1C=C(C)C=C(C)C=1)C(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 ALKDPZDQOKEMAM-MUUNZHRXSA-N 0.000 claims 1
- XURCUAXYHRFYLY-HHHXNRCGSA-N 3-[2-[[(1r)-1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(2,3,6-trifluorophenyl)methoxy]phenyl]propanoic acid Chemical compound N([C@H](CC(C)C)C=1C=C(C)C=C(C)C=1)C(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=C(F)C=CC(F)=C1F XURCUAXYHRFYLY-HHHXNRCGSA-N 0.000 claims 1
- PNWCSJWFVDCOGF-MUUNZHRXSA-N 3-[2-[[(1r)-1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(2-ethoxyphenoxy)methyl]phenyl]propanoic acid Chemical compound CCOC1=CC=CC=C1OCC1=CC=C(CCC(O)=O)C(C(=O)N[C@H](CC(C)C)C=2C=C(C)C=C(C)C=2)=C1 PNWCSJWFVDCOGF-MUUNZHRXSA-N 0.000 claims 1
- IRRPSRISINBCFR-GDLZYMKVSA-N 3-[2-[[(1r)-1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(2-ethylphenoxy)methyl]phenyl]propanoic acid Chemical compound CCC1=CC=CC=C1OCC1=CC=C(CCC(O)=O)C(C(=O)N[C@H](CC(C)C)C=2C=C(C)C=C(C)C=2)=C1 IRRPSRISINBCFR-GDLZYMKVSA-N 0.000 claims 1
- GZDWUKOMCIOVJR-HHHXNRCGSA-N 3-[2-[[(1r)-1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(2-fluorophenoxy)methyl]phenyl]propanoic acid Chemical compound N([C@H](CC(C)C)C=1C=C(C)C=C(C)C=1)C(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1F GZDWUKOMCIOVJR-HHHXNRCGSA-N 0.000 claims 1
- PUQCPIMXFYPCIE-MUUNZHRXSA-N 3-[2-[[(1r)-1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(2-methylphenoxy)methyl]phenyl]propanoic acid Chemical compound N([C@H](CC(C)C)C=1C=C(C)C=C(C)C=1)C(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1C PUQCPIMXFYPCIE-MUUNZHRXSA-N 0.000 claims 1
- JZCWPRMKQDJDBN-MUUNZHRXSA-N 3-[2-[[(1r)-1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(3-fluorophenoxy)methyl]phenyl]propanoic acid Chemical compound N([C@H](CC(C)C)C=1C=C(C)C=C(C)C=1)C(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC(F)=C1 JZCWPRMKQDJDBN-MUUNZHRXSA-N 0.000 claims 1
- UGNHEAQVFRJTQQ-MUUNZHRXSA-N 3-[2-[[(1r)-1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(4-fluorophenoxy)methyl]phenyl]propanoic acid Chemical compound N([C@H](CC(C)C)C=1C=C(C)C=C(C)C=1)C(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=C(F)C=C1 UGNHEAQVFRJTQQ-MUUNZHRXSA-N 0.000 claims 1
- DFFDZNHRSQXENZ-MUUNZHRXSA-N 3-[2-[[(1r)-1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-phenylmethoxyphenyl]propanoic acid Chemical compound N([C@H](CC(C)C)C=1C=C(C)C=C(C)C=1)C(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=CC=C1 DFFDZNHRSQXENZ-MUUNZHRXSA-N 0.000 claims 1
- IGFWKNSNGQFMTD-GOSISDBHSA-N 3-[2-[[(1r)-1-(4-methylphenyl)ethyl]carbamoyl]-4-phenoxyphenyl]propanoic acid Chemical compound N([C@H](C)C=1C=CC(C)=CC=1)C(=O)C(C(=CC=1)CCC(O)=O)=CC=1OC1=CC=CC=C1 IGFWKNSNGQFMTD-GOSISDBHSA-N 0.000 claims 1
- UREIMFBBBPBBOI-MRXNPFEDSA-N 3-[2-[[(1r)-1-(4-nitrophenyl)ethyl]carbamoyl]-4-phenoxyphenyl]propanoic acid Chemical compound N([C@H](C)C=1C=CC(=CC=1)[N+]([O-])=O)C(=O)C(C(=CC=1)CCC(O)=O)=CC=1OC1=CC=CC=C1 UREIMFBBBPBBOI-MRXNPFEDSA-N 0.000 claims 1
- VPXMPIBOESHHAF-HXUWFJFHSA-N 3-[2-[[(1r)-1-naphthalen-1-ylethyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound N([C@H](C)C=1C2=CC=CC=C2C=CC=1)C(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 VPXMPIBOESHHAF-HXUWFJFHSA-N 0.000 claims 1
- NHGWCLKIVFBVFP-LJQANCHMSA-N 3-[2-[[(1r)-1-naphthalen-1-ylethyl]carbamoyl]-4-phenoxyphenyl]propanoic acid Chemical compound N([C@H](C)C=1C2=CC=CC=C2C=CC=1)C(=O)C(C(=CC=1)CCC(O)=O)=CC=1OC1=CC=CC=C1 NHGWCLKIVFBVFP-LJQANCHMSA-N 0.000 claims 1
- VPXMPIBOESHHAF-FQEVSTJZSA-N 3-[2-[[(1s)-1-naphthalen-1-ylethyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound N([C@@H](C)C=1C2=CC=CC=C2C=CC=1)C(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 VPXMPIBOESHHAF-FQEVSTJZSA-N 0.000 claims 1
- ZYKGIGFBQREYKX-UHFFFAOYSA-N 3-[2-[[1-(1,3-benzodioxol-4-yl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC=2OCOC=2C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 ZYKGIGFBQREYKX-UHFFFAOYSA-N 0.000 claims 1
- QLDVEIFQNUNSFV-UHFFFAOYSA-N 3-[2-[[1-(1,3-benzodioxol-5-yl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C2OCOC2=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 QLDVEIFQNUNSFV-UHFFFAOYSA-N 0.000 claims 1
- AAXFIMOISUHJSR-UHFFFAOYSA-N 3-[2-[[1-(2,3-difluorophenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC(F)=C(F)C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 AAXFIMOISUHJSR-UHFFFAOYSA-N 0.000 claims 1
- XRJORJOEXYTMGE-UHFFFAOYSA-N 3-[2-[[1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C2OCCOC2=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 XRJORJOEXYTMGE-UHFFFAOYSA-N 0.000 claims 1
- QHGSWQUJQJCFAQ-UHFFFAOYSA-N 3-[2-[[1-(2,3-dimethoxyphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound COC1=CC=CC(C(CC(C)C)NC(=O)C=2C(=CC=C(COC=3C=CC=CC=3)C=2)CCC(O)=O)=C1OC QHGSWQUJQJCFAQ-UHFFFAOYSA-N 0.000 claims 1
- XTSYDBGMRAUNFZ-UHFFFAOYSA-N 3-[2-[[1-(2,3-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC(C)=C(C)C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 XTSYDBGMRAUNFZ-UHFFFAOYSA-N 0.000 claims 1
- XKIBSNIVJKVSHJ-UHFFFAOYSA-N 3-[2-[[1-(2,4-diethoxy-3-methylphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound CCOC1=C(C)C(OCC)=CC=C1C(CC(C)C)NC(=O)C1=CC(COC=2C=CC=CC=2)=CC=C1CCC(O)=O XKIBSNIVJKVSHJ-UHFFFAOYSA-N 0.000 claims 1
- FYKNAZJZSBZWPF-UHFFFAOYSA-N 3-[2-[[1-(2,4-difluorophenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(F)C=C(F)C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 FYKNAZJZSBZWPF-UHFFFAOYSA-N 0.000 claims 1
- QLZSCSMDSZXRIO-UHFFFAOYSA-N 3-[2-[[1-(2,4-dimethoxyphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound COC1=CC(OC)=CC=C1C(CC(C)C)NC(=O)C1=CC(COC=2C=CC=CC=2)=CC=C1CCC(O)=O QLZSCSMDSZXRIO-UHFFFAOYSA-N 0.000 claims 1
- MVLOACPGPINNJT-UHFFFAOYSA-N 3-[2-[[1-(2,4-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(C)C=C(C)C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 MVLOACPGPINNJT-UHFFFAOYSA-N 0.000 claims 1
- XZLDMWMKRJVEIU-UHFFFAOYSA-N 3-[2-[[1-(2,5-difluorophenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C(F)=CC=C(F)C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 XZLDMWMKRJVEIU-UHFFFAOYSA-N 0.000 claims 1
- VNXHRPUQXMOAFF-UHFFFAOYSA-N 3-[2-[[1-(2,5-dimethoxyphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound COC1=CC=C(OC)C(C(CC(C)C)NC(=O)C=2C(=CC=C(COC=3C=CC=CC=3)C=2)CCC(O)=O)=C1 VNXHRPUQXMOAFF-UHFFFAOYSA-N 0.000 claims 1
- AONRZGSDLNUXDP-UHFFFAOYSA-N 3-[2-[[1-(2,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C(C)=CC=C(C)C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 AONRZGSDLNUXDP-UHFFFAOYSA-N 0.000 claims 1
- ITINWLZSSDPNDT-UHFFFAOYSA-N 3-[2-[[1-(2-chloro-3,4-dimethoxyphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound ClC1=C(OC)C(OC)=CC=C1C(CC(C)C)NC(=O)C1=CC(COC=2C=CC=CC=2)=CC=C1CCC(O)=O ITINWLZSSDPNDT-UHFFFAOYSA-N 0.000 claims 1
- ZJLDKBPPAGSEIR-UHFFFAOYSA-N 3-[2-[[1-(2-chloro-4-fluorophenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(F)C=C(Cl)C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 ZJLDKBPPAGSEIR-UHFFFAOYSA-N 0.000 claims 1
- MAAMUVBOLFVZCQ-UHFFFAOYSA-N 3-[2-[[1-(2-chloro-6-fluorophenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound FC=1C=CC=C(Cl)C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 MAAMUVBOLFVZCQ-UHFFFAOYSA-N 0.000 claims 1
- NGJSUXPVXJJXGO-UHFFFAOYSA-N 3-[2-[[1-(2-fluoro-4,5-dimethoxyphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C1=C(OC)C(OC)=CC(F)=C1C(CC(C)C)NC(=O)C1=CC(COC=2C=CC=CC=2)=CC=C1CCC(O)=O NGJSUXPVXJJXGO-UHFFFAOYSA-N 0.000 claims 1
- XCNHANCTSPNOHZ-UHFFFAOYSA-N 3-[2-[[1-(2-fluoro-4-methoxyphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound FC1=CC(OC)=CC=C1C(CC(C)C)NC(=O)C1=CC(COC=2C=CC=CC=2)=CC=C1CCC(O)=O XCNHANCTSPNOHZ-UHFFFAOYSA-N 0.000 claims 1
- BPKQQZBXGZCBNJ-UHFFFAOYSA-N 3-[2-[[1-(2-fluoro-5-methoxyphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound COC1=CC=C(F)C(C(CC(C)C)NC(=O)C=2C(=CC=C(COC=3C=CC=CC=3)C=2)CCC(O)=O)=C1 BPKQQZBXGZCBNJ-UHFFFAOYSA-N 0.000 claims 1
- ZUASJMLJMPWKTC-UHFFFAOYSA-N 3-[2-[[1-(2-fluorophenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC=C(F)C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 ZUASJMLJMPWKTC-UHFFFAOYSA-N 0.000 claims 1
- KUCZKCPBBRFXSS-UHFFFAOYSA-N 3-[2-[[1-(2-methoxy-5-methylphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound COC1=CC=C(C)C=C1C(CC(C)C)NC(=O)C1=CC(COC=2C=CC=CC=2)=CC=C1CCC(O)=O KUCZKCPBBRFXSS-UHFFFAOYSA-N 0.000 claims 1
- ALGGHMKJRRYWGC-UHFFFAOYSA-N 3-[2-[[1-(2-methoxyphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound COC1=CC=CC=C1C(CC(C)C)NC(=O)C1=CC(COC=2C=CC=CC=2)=CC=C1CCC(O)=O ALGGHMKJRRYWGC-UHFFFAOYSA-N 0.000 claims 1
- ZZFGJZPZWSOMMI-UHFFFAOYSA-N 3-[2-[[1-(3,4-diethoxyphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C1=C(OCC)C(OCC)=CC=C1C(CC(C)C)NC(=O)C1=CC(COC=2C=CC=CC=2)=CC=C1CCC(O)=O ZZFGJZPZWSOMMI-UHFFFAOYSA-N 0.000 claims 1
- HRIVQOQOXZBHSD-UHFFFAOYSA-N 3-[2-[[1-(3,4-difluorophenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(F)C(F)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 HRIVQOQOXZBHSD-UHFFFAOYSA-N 0.000 claims 1
- MOTOKILOGAVSPV-UHFFFAOYSA-N 3-[2-[[1-(3,4-dimethoxyphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C1=C(OC)C(OC)=CC=C1C(CC(C)C)NC(=O)C1=CC(COC=2C=CC=CC=2)=CC=C1CCC(O)=O MOTOKILOGAVSPV-UHFFFAOYSA-N 0.000 claims 1
- QPNYAFGLQDXISG-UHFFFAOYSA-N 3-[2-[[1-(3,4-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(C)C(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 QPNYAFGLQDXISG-UHFFFAOYSA-N 0.000 claims 1
- CJODOKPDAJOKEM-UHFFFAOYSA-N 3-[2-[[1-(3,5-dichlorophenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C(Cl)=CC(Cl)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 CJODOKPDAJOKEM-UHFFFAOYSA-N 0.000 claims 1
- REBKSXOXFFOVNC-UHFFFAOYSA-N 3-[2-[[1-(3,5-difluorophenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C(F)=CC(F)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 REBKSXOXFFOVNC-UHFFFAOYSA-N 0.000 claims 1
- XOWIMBRARWJXRI-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethoxyphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound COC1=CC(OC)=CC(C(CC(C)C)NC(=O)C=2C(=CC=C(COC=3C=CC=CC=3)C=2)CCC(O)=O)=C1 XOWIMBRARWJXRI-UHFFFAOYSA-N 0.000 claims 1
- OOWXTDYAVUBDIW-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethoxyphenyl)-3-methylbutyl]carbamoyl]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound COC1=CC(OC)=CC(C(CC(C)C)NC(=O)C=2C(=CC=C(CN3N=CC=C3)C=2)CCC(O)=O)=C1 OOWXTDYAVUBDIW-UHFFFAOYSA-N 0.000 claims 1
- WEDPISMOXXKWNZ-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-(2-phenylethenyl)phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1C=CC1=CC=CC=C1 WEDPISMOXXKWNZ-UHFFFAOYSA-N 0.000 claims 1
- WKDADHREOZASGE-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-(2-phenylethoxy)phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCCC1=CC=CC=C1 WKDADHREOZASGE-UHFFFAOYSA-N 0.000 claims 1
- MSGWTSCRZRXCNE-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-(2-pyrazol-1-ylacetyl)phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1C(=O)CN1C=CC=N1 MSGWTSCRZRXCNE-UHFFFAOYSA-N 0.000 claims 1
- VPRYLAHDAIKCLF-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-(2-pyrazol-1-ylethyl)phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1CCN1C=CC=N1 VPRYLAHDAIKCLF-UHFFFAOYSA-N 0.000 claims 1
- OVKYBUOEDQHXNI-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-(3-phenylpropoxy)phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCCCC1=CC=CC=C1 OVKYBUOEDQHXNI-UHFFFAOYSA-N 0.000 claims 1
- RLWGJDCNOLWVIG-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-(9h-fluoren-2-ylmethoxy)phenyl]propanoic acid Chemical compound C=1C(OCC=2C=C3C(C4=CC=CC=C4C3)=CC=2)=CC=C(CCC(O)=O)C=1C(=O)NC(CC(C)C)C1=CC(C)=CC(C)=C1 RLWGJDCNOLWVIG-UHFFFAOYSA-N 0.000 claims 1
- TZAWYBGBGTVSPT-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-(furan-2-ylmethoxy)phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=CO1 TZAWYBGBGTVSPT-UHFFFAOYSA-N 0.000 claims 1
- JFICBGPIKAWWGM-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-(naphthalen-1-ylmethoxy)phenyl]propanoic acid Chemical compound C=1C(OCC=2C3=CC=CC=C3C=CC=2)=CC=C(CCC(O)=O)C=1C(=O)NC(CC(C)C)C1=CC(C)=CC(C)=C1 JFICBGPIKAWWGM-UHFFFAOYSA-N 0.000 claims 1
- RXQWWNIIQGYCPL-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxycarbonylamino)phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1NC(=O)OC1=CC=CC=C1 RXQWWNIIQGYCPL-UHFFFAOYSA-N 0.000 claims 1
- ALKDPZDQOKEMAM-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 ALKDPZDQOKEMAM-UHFFFAOYSA-N 0.000 claims 1
- DMWKAWOBOISDPA-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-(phenylcarbamoyl)phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1C(=O)NC1=CC=CC=C1 DMWKAWOBOISDPA-UHFFFAOYSA-N 0.000 claims 1
- MMFOUEHSJUWTJX-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-(phenylcarbamoylamino)phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1NC(=O)NC1=CC=CC=C1 MMFOUEHSJUWTJX-UHFFFAOYSA-N 0.000 claims 1
- VJJDXJBSTIOWCQ-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-(phenylmethoxycarbonylamino)phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1NC(=O)OCC1=CC=CC=C1 VJJDXJBSTIOWCQ-UHFFFAOYSA-N 0.000 claims 1
- KAMJCLPZLJOYFY-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1CN1C=CC=N1 KAMJCLPZLJOYFY-UHFFFAOYSA-N 0.000 claims 1
- GHYYWBKTACZBAG-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-(pyridin-3-yloxymethyl)phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CN=C1 GHYYWBKTACZBAG-UHFFFAOYSA-N 0.000 claims 1
- MTMVHBMMVIZSEP-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(2,3,4,5,6-pentafluorophenoxy)methyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=C(F)C(F)=C(F)C(F)=C1F MTMVHBMMVIZSEP-UHFFFAOYSA-N 0.000 claims 1
- ONNXIWUSOHUSGW-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(2,3,4,5,6-pentafluorophenyl)methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=C(F)C(F)=C(F)C(F)=C1F ONNXIWUSOHUSGW-UHFFFAOYSA-N 0.000 claims 1
- GFOJORYZAPZDBP-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(2,3,5,6-tetrafluorophenoxy)methyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=C(F)C(F)=CC(F)=C1F GFOJORYZAPZDBP-UHFFFAOYSA-N 0.000 claims 1
- IFTUTOPCDUBZDZ-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(2,3,5,6-tetrafluorophenyl)methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=C(F)C(F)=CC(F)=C1F IFTUTOPCDUBZDZ-UHFFFAOYSA-N 0.000 claims 1
- VLHUGDJLDKAHFM-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(2,3,5-trifluorophenyl)methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC(F)=CC(F)=C1F VLHUGDJLDKAHFM-UHFFFAOYSA-N 0.000 claims 1
- JRYOOZNMOGPFGX-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(2,3,6-trifluorophenoxy)methyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=C(F)C=CC(F)=C1F JRYOOZNMOGPFGX-UHFFFAOYSA-N 0.000 claims 1
- XURCUAXYHRFYLY-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(2,3,6-trifluorophenyl)methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=C(F)C=CC(F)=C1F XURCUAXYHRFYLY-UHFFFAOYSA-N 0.000 claims 1
- ICMVTUJRGKYXLR-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(2,4,5-trimethylphenyl)methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC(C)=C(C)C=C1C ICMVTUJRGKYXLR-UHFFFAOYSA-N 0.000 claims 1
- GJHVNXQQTOOIRS-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(2,4,6-trifluorophenyl)methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=C(F)C=C(F)C=C1F GJHVNXQQTOOIRS-UHFFFAOYSA-N 0.000 claims 1
- AJDGBSPSJOBEGM-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(2-ethyl-5-methylpyrazol-3-yl)methoxy]phenyl]propanoic acid Chemical compound CCN1N=C(C)C=C1COC1=CC=C(CCC(O)=O)C(C(=O)NC(CC(C)C)C=2C=C(C)C=C(C)C=2)=C1 AJDGBSPSJOBEGM-UHFFFAOYSA-N 0.000 claims 1
- IRMZMUZCPYZCND-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(2-ethylphenyl)methoxy]phenyl]propanoic acid Chemical compound CCC1=CC=CC=C1COC1=CC=C(CCC(O)=O)C(C(=O)NC(CC(C)C)C=2C=C(C)C=C(C)C=2)=C1 IRMZMUZCPYZCND-UHFFFAOYSA-N 0.000 claims 1
- FETWWDDMZRMSNX-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(2-fluoro-5-methoxyphenyl)methoxy]phenyl]propanoic acid Chemical compound COC1=CC=C(F)C(COC=2C=C(C(CCC(O)=O)=CC=2)C(=O)NC(CC(C)C)C=2C=C(C)C=C(C)C=2)=C1 FETWWDDMZRMSNX-UHFFFAOYSA-N 0.000 claims 1
- HOCMEXGYXHRFEQ-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(2-fluoro-5-methylphenoxy)methyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC(C)=CC=C1F HOCMEXGYXHRFEQ-UHFFFAOYSA-N 0.000 claims 1
- ABDFKXJDOCPUNH-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(2-fluoro-6-methoxyphenoxy)methyl]phenyl]propanoic acid Chemical compound COC1=CC=CC(F)=C1OCC1=CC=C(CCC(O)=O)C(C(=O)NC(CC(C)C)C=2C=C(C)C=C(C)C=2)=C1 ABDFKXJDOCPUNH-UHFFFAOYSA-N 0.000 claims 1
- GZDWUKOMCIOVJR-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(2-fluorophenoxy)methyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1F GZDWUKOMCIOVJR-UHFFFAOYSA-N 0.000 claims 1
- LKQZSRBFLFASRE-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(2-fluorophenyl)methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=CC=C1F LKQZSRBFLFASRE-UHFFFAOYSA-N 0.000 claims 1
- RFGGOBQCGHAPAT-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(2-methoxy-5-methylphenoxy)methyl]phenyl]propanoic acid Chemical compound COC1=CC=C(C)C=C1OCC1=CC=C(CCC(O)=O)C(C(=O)NC(CC(C)C)C=2C=C(C)C=C(C)C=2)=C1 RFGGOBQCGHAPAT-UHFFFAOYSA-N 0.000 claims 1
- FPJPJFWNTWKYPZ-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(2-methoxynaphthalen-1-yl)methoxy]phenyl]propanoic acid Chemical compound COC1=CC=C2C=CC=CC2=C1COC(C=1)=CC=C(CCC(O)=O)C=1C(=O)NC(CC(C)C)C1=CC(C)=CC(C)=C1 FPJPJFWNTWKYPZ-UHFFFAOYSA-N 0.000 claims 1
- QZNQZQBZJIZFSU-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(2-methoxyphenoxy)methyl]phenyl]propanoic acid Chemical compound COC1=CC=CC=C1OCC1=CC=C(CCC(O)=O)C(C(=O)NC(CC(C)C)C=2C=C(C)C=C(C)C=2)=C1 QZNQZQBZJIZFSU-UHFFFAOYSA-N 0.000 claims 1
- LWIMTZQWIMXTRA-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(2-methoxyphenyl)methoxy]phenyl]propanoic acid Chemical compound COC1=CC=CC=C1COC1=CC=C(CCC(O)=O)C(C(=O)NC(CC(C)C)C=2C=C(C)C=C(C)C=2)=C1 LWIMTZQWIMXTRA-UHFFFAOYSA-N 0.000 claims 1
- PUQCPIMXFYPCIE-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(2-methylphenoxy)methyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1C PUQCPIMXFYPCIE-UHFFFAOYSA-N 0.000 claims 1
- UVLVWCHWMVBLMF-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(2-methylphenyl)methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=CC=C1C UVLVWCHWMVBLMF-UHFFFAOYSA-N 0.000 claims 1
- AWSPKWKKHIXJGG-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(2-phenoxyphenyl)methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=CC=C1OC1=CC=CC=C1 AWSPKWKKHIXJGG-UHFFFAOYSA-N 0.000 claims 1
- ULOLXEDTORDQEM-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(2-phenylphenyl)methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=CC=C1C1=CC=CC=C1 ULOLXEDTORDQEM-UHFFFAOYSA-N 0.000 claims 1
- WFXWUAQGQICCKJ-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(3,4,5-trifluorophenyl)methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC(F)=C(F)C(F)=C1 WFXWUAQGQICCKJ-UHFFFAOYSA-N 0.000 claims 1
- LICZEXUAWLCGFX-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(3-ethoxyphenyl)methoxy]phenyl]propanoic acid Chemical compound CCOC1=CC=CC(COC=2C=C(C(CCC(O)=O)=CC=2)C(=O)NC(CC(C)C)C=2C=C(C)C=C(C)C=2)=C1 LICZEXUAWLCGFX-UHFFFAOYSA-N 0.000 claims 1
- PRPFAHXBRQEBRX-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(3-fluoro-2-methylphenyl)methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=CC(F)=C1C PRPFAHXBRQEBRX-UHFFFAOYSA-N 0.000 claims 1
- QWYGQDDFTMGANV-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(3-fluoro-4-methylphenyl)methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=C(C)C(F)=C1 QWYGQDDFTMGANV-UHFFFAOYSA-N 0.000 claims 1
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- XHQMBWJHKYTBIW-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(3-methoxy-4-methylphenyl)methoxy]phenyl]propanoic acid Chemical compound C1=C(C)C(OC)=CC(COC=2C=C(C(CCC(O)=O)=CC=2)C(=O)NC(CC(C)C)C=2C=C(C)C=C(C)C=2)=C1 XHQMBWJHKYTBIW-UHFFFAOYSA-N 0.000 claims 1
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- VQNOXGXKPGYDCD-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(3-methylphenoxy)methyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC(C)=C1 VQNOXGXKPGYDCD-UHFFFAOYSA-N 0.000 claims 1
- OUFHYXAPUYHBEN-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(3-methylphenyl)methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=CC(C)=C1 OUFHYXAPUYHBEN-UHFFFAOYSA-N 0.000 claims 1
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- SYUCIKHWXXCYCM-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(4-fluoro-3-methoxyphenyl)methoxy]phenyl]propanoic acid Chemical compound C1=C(F)C(OC)=CC(COC=2C=C(C(CCC(O)=O)=CC=2)C(=O)NC(CC(C)C)C=2C=C(C)C=C(C)C=2)=C1 SYUCIKHWXXCYCM-UHFFFAOYSA-N 0.000 claims 1
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- YDXONEXIIXVUPP-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(4-methoxy-2-methylphenyl)methoxy]phenyl]propanoic acid Chemical compound CC1=CC(OC)=CC=C1COC1=CC=C(CCC(O)=O)C(C(=O)NC(CC(C)C)C=2C=C(C)C=C(C)C=2)=C1 YDXONEXIIXVUPP-UHFFFAOYSA-N 0.000 claims 1
- VBSAJSWRCVNKTQ-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(4-methoxynaphthalen-1-yl)methoxy]phenyl]propanoic acid Chemical compound C12=CC=CC=C2C(OC)=CC=C1COC(C=1)=CC=C(CCC(O)=O)C=1C(=O)NC(CC(C)C)C1=CC(C)=CC(C)=C1 VBSAJSWRCVNKTQ-UHFFFAOYSA-N 0.000 claims 1
- DSKZESYGXOGKHJ-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(4-methoxyphenoxy)methyl]phenyl]propanoic acid Chemical compound C1=CC(OC)=CC=C1OCC1=CC=C(CCC(O)=O)C(C(=O)NC(CC(C)C)C=2C=C(C)C=C(C)C=2)=C1 DSKZESYGXOGKHJ-UHFFFAOYSA-N 0.000 claims 1
- IVTHOCVCKRQUJP-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(4-methoxyphenyl)methoxy]phenyl]propanoic acid Chemical compound C1=CC(OC)=CC=C1COC1=CC=C(CCC(O)=O)C(C(=O)NC(CC(C)C)C=2C=C(C)C=C(C)C=2)=C1 IVTHOCVCKRQUJP-UHFFFAOYSA-N 0.000 claims 1
- ZXVRSTJAKHZMKR-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(4-methylnaphthalen-1-yl)methoxy]phenyl]propanoic acid Chemical compound C=1C(OCC=2C3=CC=CC=C3C(C)=CC=2)=CC=C(CCC(O)=O)C=1C(=O)NC(CC(C)C)C1=CC(C)=CC(C)=C1 ZXVRSTJAKHZMKR-UHFFFAOYSA-N 0.000 claims 1
- FTAFMJDXEACGGN-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(4-methylphenoxy)methyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=C(C)C=C1 FTAFMJDXEACGGN-UHFFFAOYSA-N 0.000 claims 1
- WAKKNTSZMBESFJ-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(4-methylphenyl)methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=C(C)C=C1 WAKKNTSZMBESFJ-UHFFFAOYSA-N 0.000 claims 1
- IMBFVXJKIBRGIJ-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(4-methylsulfanylphenyl)methoxy]phenyl]propanoic acid Chemical compound C1=CC(SC)=CC=C1COC1=CC=C(CCC(O)=O)C(C(=O)NC(CC(C)C)C=2C=C(C)C=C(C)C=2)=C1 IMBFVXJKIBRGIJ-UHFFFAOYSA-N 0.000 claims 1
- CRVULHOFWPWWTR-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(4-methylsulfonylphenyl)methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=C(S(C)(=O)=O)C=C1 CRVULHOFWPWWTR-UHFFFAOYSA-N 0.000 claims 1
- GNNBUXVKGHLJNT-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(4-pentylphenyl)methoxy]phenyl]propanoic acid Chemical compound C1=CC(CCCCC)=CC=C1COC1=CC=C(CCC(O)=O)C(C(=O)NC(CC(C)C)C=2C=C(C)C=C(C)C=2)=C1 GNNBUXVKGHLJNT-UHFFFAOYSA-N 0.000 claims 1
- SJLRATGYNZEPIO-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(4-phenoxyphenyl)methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC(C=C1)=CC=C1OC1=CC=CC=C1 SJLRATGYNZEPIO-UHFFFAOYSA-N 0.000 claims 1
- BUDGMGABVWSDQT-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(4-phenylmethoxyphenyl)methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC(C=C1)=CC=C1OCC1=CC=CC=C1 BUDGMGABVWSDQT-UHFFFAOYSA-N 0.000 claims 1
- CFPWMURWTJHSEK-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(4-phenylphenyl)methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC(C=C1)=CC=C1C1=CC=CC=C1 CFPWMURWTJHSEK-UHFFFAOYSA-N 0.000 claims 1
- FKPSNVIFRABYBW-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(4-propan-2-ylphenyl)methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=C(C(C)C)C=C1 FKPSNVIFRABYBW-UHFFFAOYSA-N 0.000 claims 1
- ZQFZXRDRRIORBP-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(4-pyridin-2-ylphenyl)methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC(C=C1)=CC=C1C1=CC=CC=N1 ZQFZXRDRRIORBP-UHFFFAOYSA-N 0.000 claims 1
- QVUJOHOAAXRSNR-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[(5-fluoro-2-methylphenyl)methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC(F)=CC=C1C QVUJOHOAAXRSNR-UHFFFAOYSA-N 0.000 claims 1
- AMEDRCADUKVFDI-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCCC(=C(O1)C)N=C1C1=CC=CC=C1 AMEDRCADUKVFDI-UHFFFAOYSA-N 0.000 claims 1
- XLTHRBCJWILOLR-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[[2-(trifluoromethoxy)phenyl]methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=CC=C1OC(F)(F)F XLTHRBCJWILOLR-UHFFFAOYSA-N 0.000 claims 1
- TWTXNNVUCWGJRF-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[[2-(trifluoromethyl)phenyl]methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=CC=C1C(F)(F)F TWTXNNVUCWGJRF-UHFFFAOYSA-N 0.000 claims 1
- SKDAWLHNGHWICK-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[[2-fluoro-4-(trifluoromethyl)phenyl]methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=C(C(F)(F)F)C=C1F SKDAWLHNGHWICK-UHFFFAOYSA-N 0.000 claims 1
- SOVAVEZOWPYMIY-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC(C(F)(F)F)=CC=C1F SOVAVEZOWPYMIY-UHFFFAOYSA-N 0.000 claims 1
- OVZPCLVOKHGUCN-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[[2-fluoro-6-(trifluoromethyl)phenyl]methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=C(F)C=CC=C1C(F)(F)F OVZPCLVOKHGUCN-UHFFFAOYSA-N 0.000 claims 1
- NPIRBIVPGPPHIM-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[[3-(4-methoxyphenoxy)phenyl]methoxy]phenyl]propanoic acid Chemical compound C1=CC(OC)=CC=C1OC1=CC=CC(COC=2C=C(C(CCC(O)=O)=CC=2)C(=O)NC(CC(C)C)C=2C=C(C)C=C(C)C=2)=C1 NPIRBIVPGPPHIM-UHFFFAOYSA-N 0.000 claims 1
- PQETYGJIVJUJCY-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[[3-(4-methylphenoxy)phenyl]methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC(C=1)=CC=CC=1OC1=CC=C(C)C=C1 PQETYGJIVJUJCY-UHFFFAOYSA-N 0.000 claims 1
- RPGMMQMABPDGAN-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[[3-(hydroxymethyl)phenoxy]methyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC(CO)=C1 RPGMMQMABPDGAN-UHFFFAOYSA-N 0.000 claims 1
- OWYWTFDSQABSTI-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[[3-(methoxymethyl)phenoxy]methyl]phenyl]propanoic acid Chemical compound COCC1=CC=CC(OCC=2C=C(C(CCC(O)=O)=CC=2)C(=O)NC(CC(C)C)C=2C=C(C)C=C(C)C=2)=C1 OWYWTFDSQABSTI-UHFFFAOYSA-N 0.000 claims 1
- LMAWAZKWMYIFST-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[[3-(methylcarbamoyl)phenoxy]methyl]phenyl]propanoic acid Chemical compound CNC(=O)C1=CC=CC(OCC=2C=C(C(CCC(O)=O)=CC=2)C(=O)NC(CC(C)C)C=2C=C(C)C=C(C)C=2)=C1 LMAWAZKWMYIFST-UHFFFAOYSA-N 0.000 claims 1
- ARFDGTPPDLPRON-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[[3-(trifluoromethoxy)phenyl]methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=CC(OC(F)(F)F)=C1 ARFDGTPPDLPRON-UHFFFAOYSA-N 0.000 claims 1
- KCBDIFLXXLGLOM-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[[3-(trifluoromethyl)phenyl]methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=CC(C(F)(F)F)=C1 KCBDIFLXXLGLOM-UHFFFAOYSA-N 0.000 claims 1
- JPMPUILIHDZLEV-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[[3-(trifluoromethylsulfanyl)phenyl]methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=CC(SC(F)(F)F)=C1 JPMPUILIHDZLEV-UHFFFAOYSA-N 0.000 claims 1
- NUDNSLRRLYGHCD-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[[3-[3-(trifluoromethyl)phenoxy]phenyl]methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC(C=1)=CC=CC=1OC1=CC=CC(C(F)(F)F)=C1 NUDNSLRRLYGHCD-UHFFFAOYSA-N 0.000 claims 1
- GELZQXIDSZOWKV-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[[3-fluoro-4-(trifluoromethyl)phenyl]methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=C(C(F)(F)F)C(F)=C1 GELZQXIDSZOWKV-UHFFFAOYSA-N 0.000 claims 1
- HMWCDYJEASKVEI-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[[3-fluoro-5-(trifluoromethyl)phenyl]methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC(F)=CC(C(F)(F)F)=C1 HMWCDYJEASKVEI-UHFFFAOYSA-N 0.000 claims 1
- YKXSBILEHARWPP-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[[4-(2-methylpropyl)phenyl]methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=C(CC(C)C)C=C1 YKXSBILEHARWPP-UHFFFAOYSA-N 0.000 claims 1
- VCZFVDMREQQGCK-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[[4-(4-propylphenyl)phenyl]methoxy]phenyl]propanoic acid Chemical compound C1=CC(CCC)=CC=C1C(C=C1)=CC=C1COC1=CC=C(CCC(O)=O)C(C(=O)NC(CC(C)C)C=2C=C(C)C=C(C)C=2)=C1 VCZFVDMREQQGCK-UHFFFAOYSA-N 0.000 claims 1
- JQINODQNAIQSBO-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[[4-(trifluoromethoxy)phenyl]methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=C(OC(F)(F)F)C=C1 JQINODQNAIQSBO-UHFFFAOYSA-N 0.000 claims 1
- SVPQCAHEHCHVMV-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[[4-(trifluoromethylsulfanyl)phenyl]methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=C(SC(F)(F)F)C=C1 SVPQCAHEHCHVMV-UHFFFAOYSA-N 0.000 claims 1
- QMOYCYIPCLYOCD-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[[4-[(4-fluorophenyl)methoxy]phenyl]methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC(C=C1)=CC=C1OCC1=CC=C(F)C=C1 QMOYCYIPCLYOCD-UHFFFAOYSA-N 0.000 claims 1
- XPAAZVLRIDJEEN-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-[[4-fluoro-3-(trifluoromethyl)phenyl]methoxy]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=C(F)C(C(F)(F)F)=C1 XPAAZVLRIDJEEN-UHFFFAOYSA-N 0.000 claims 1
- XNTSBVOETDBBMR-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-phenoxyphenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OC1=CC=CC=C1 XNTSBVOETDBBMR-UHFFFAOYSA-N 0.000 claims 1
- DFFDZNHRSQXENZ-UHFFFAOYSA-N 3-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-phenylmethoxyphenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=CC=C1 DFFDZNHRSQXENZ-UHFFFAOYSA-N 0.000 claims 1
- FWASKMZBRDMIFV-UHFFFAOYSA-N 3-[2-[[1-(3-chloro-4-fluorophenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(F)C(Cl)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 FWASKMZBRDMIFV-UHFFFAOYSA-N 0.000 claims 1
- VPTKQCSHGRXJBG-UHFFFAOYSA-N 3-[2-[[1-(3-chlorophenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC(Cl)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 VPTKQCSHGRXJBG-UHFFFAOYSA-N 0.000 claims 1
- RCNNOLTZBKGMGS-UHFFFAOYSA-N 3-[2-[[1-(3-ethylphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound CCC1=CC=CC(C(CC(C)C)NC(=O)C=2C(=CC=C(COC=3C=CC=CC=3)C=2)CCC(O)=O)=C1 RCNNOLTZBKGMGS-UHFFFAOYSA-N 0.000 claims 1
- IWRFOKCKOVMJGN-UHFFFAOYSA-N 3-[2-[[1-(3-fluoro-2-methylphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC(F)=C(C)C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 IWRFOKCKOVMJGN-UHFFFAOYSA-N 0.000 claims 1
- WWXJECJLRYIVOD-UHFFFAOYSA-N 3-[2-[[1-(3-fluoro-4-methoxyphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C1=C(F)C(OC)=CC=C1C(CC(C)C)NC(=O)C1=CC(COC=2C=CC=CC=2)=CC=C1CCC(O)=O WWXJECJLRYIVOD-UHFFFAOYSA-N 0.000 claims 1
- OWFLBMKLSVEXQW-UHFFFAOYSA-N 3-[2-[[1-(3-fluoro-4-methylphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(C)C(F)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 OWFLBMKLSVEXQW-UHFFFAOYSA-N 0.000 claims 1
- ZKWLYZRHRQHRJH-UHFFFAOYSA-N 3-[2-[[1-(3-fluorophenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC(F)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 ZKWLYZRHRQHRJH-UHFFFAOYSA-N 0.000 claims 1
- HQKJWIPMGGAVGS-UHFFFAOYSA-N 3-[2-[[1-(3-methoxyphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound COC1=CC=CC(C(CC(C)C)NC(=O)C=2C(=CC=C(COC=3C=CC=CC=3)C=2)CCC(O)=O)=C1 HQKJWIPMGGAVGS-UHFFFAOYSA-N 0.000 claims 1
- OVFPIKRHJVHLNB-UHFFFAOYSA-N 3-[2-[[1-(4-acetamidophenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(NC(C)=O)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 OVFPIKRHJVHLNB-UHFFFAOYSA-N 0.000 claims 1
- BLWCKKBBDFTXQX-UHFFFAOYSA-N 3-[2-[[1-(4-butoxyphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C1=CC(OCCCC)=CC=C1C(CC(C)C)NC(=O)C1=CC(COC=2C=CC=CC=2)=CC=C1CCC(O)=O BLWCKKBBDFTXQX-UHFFFAOYSA-N 0.000 claims 1
- DYACSKUAMMZKOY-UHFFFAOYSA-N 3-[2-[[1-(4-butylphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C1=CC(CCCC)=CC=C1C(CC(C)C)NC(=O)C1=CC(COC=2C=CC=CC=2)=CC=C1CCC(O)=O DYACSKUAMMZKOY-UHFFFAOYSA-N 0.000 claims 1
- MSASBJUWVVTLTP-UHFFFAOYSA-N 3-[2-[[1-(4-chloro-2-fluorophenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(Cl)C=C(F)C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 MSASBJUWVVTLTP-UHFFFAOYSA-N 0.000 claims 1
- YOLNGCRHCOHOGQ-UHFFFAOYSA-N 3-[2-[[1-(4-chloro-3-fluorophenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(Cl)C(F)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 YOLNGCRHCOHOGQ-UHFFFAOYSA-N 0.000 claims 1
- LIHNAFWESVHZMA-UHFFFAOYSA-N 3-[2-[[1-(4-chlorophenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(Cl)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 LIHNAFWESVHZMA-UHFFFAOYSA-N 0.000 claims 1
- FBRGSUYFQKZWQR-UHFFFAOYSA-N 3-[2-[[1-(4-cyanophenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(C#N)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 FBRGSUYFQKZWQR-UHFFFAOYSA-N 0.000 claims 1
- AELVMSMJPUCPDO-UHFFFAOYSA-N 3-[2-[[1-(4-ethoxy-3-methoxyphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C1=C(OC)C(OCC)=CC=C1C(CC(C)C)NC(=O)C1=CC(COC=2C=CC=CC=2)=CC=C1CCC(O)=O AELVMSMJPUCPDO-UHFFFAOYSA-N 0.000 claims 1
- IAIVBZAWLWBFTB-UHFFFAOYSA-N 3-[2-[[1-(4-ethoxyphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C1=CC(OCC)=CC=C1C(CC(C)C)NC(=O)C1=CC(COC=2C=CC=CC=2)=CC=C1CCC(O)=O IAIVBZAWLWBFTB-UHFFFAOYSA-N 0.000 claims 1
- CHDBLABFMCZCMD-UHFFFAOYSA-N 3-[2-[[1-(4-ethylphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C1=CC(CC)=CC=C1C(CC(C)C)NC(=O)C1=CC(COC=2C=CC=CC=2)=CC=C1CCC(O)=O CHDBLABFMCZCMD-UHFFFAOYSA-N 0.000 claims 1
- YTJQSAHVAKEXRX-UHFFFAOYSA-N 3-[2-[[1-(4-ethylsulfanylphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C1=CC(SCC)=CC=C1C(CC(C)C)NC(=O)C1=CC(COC=2C=CC=CC=2)=CC=C1CCC(O)=O YTJQSAHVAKEXRX-UHFFFAOYSA-N 0.000 claims 1
- UDBHTCORIYCJLG-UHFFFAOYSA-N 3-[2-[[1-(4-fluoro-2-methylphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(F)C=C(C)C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 UDBHTCORIYCJLG-UHFFFAOYSA-N 0.000 claims 1
- PFPFPRXUFLKLGR-UHFFFAOYSA-N 3-[2-[[1-(4-fluoro-3-methylphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(F)C(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 PFPFPRXUFLKLGR-UHFFFAOYSA-N 0.000 claims 1
- RSZDXFVVEUWMQH-UHFFFAOYSA-N 3-[2-[[1-(4-fluoro-3-methylphenyl)-3-methylbutyl]carbamoyl]-4-[(2-methylphenoxy)methyl]phenyl]propanoic acid Chemical compound C=1C=C(F)C(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1C RSZDXFVVEUWMQH-UHFFFAOYSA-N 0.000 claims 1
- PVWBVWDWGDUJCX-UHFFFAOYSA-N 3-[2-[[1-(4-fluorophenyl)-3-methylbutyl]carbamoyl]-4-(pyridin-3-yloxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(F)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CN=C1 PVWBVWDWGDUJCX-UHFFFAOYSA-N 0.000 claims 1
- VSAMWUNEGFPPQM-UHFFFAOYSA-N 3-[2-[[1-(4-fluorophenyl)-3-methylbutyl]carbamoyl]-4-[(2-methoxyphenoxy)methyl]phenyl]propanoic acid Chemical compound COC1=CC=CC=C1OCC1=CC=C(CCC(O)=O)C(C(=O)NC(CC(C)C)C=2C=CC(F)=CC=2)=C1 VSAMWUNEGFPPQM-UHFFFAOYSA-N 0.000 claims 1
- MAHMPJZTQATKAD-UHFFFAOYSA-N 3-[2-[[1-(4-fluorophenyl)-3-methylbutyl]carbamoyl]-4-[(2-methylphenoxy)methyl]phenyl]propanoic acid Chemical compound C=1C=C(F)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1C MAHMPJZTQATKAD-UHFFFAOYSA-N 0.000 claims 1
- QHSYGKUGFLDHTC-UHFFFAOYSA-N 3-[2-[[1-(4-methoxy-2,3-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound CC1=C(C)C(OC)=CC=C1C(CC(C)C)NC(=O)C1=CC(COC=2C=CC=CC=2)=CC=C1CCC(O)=O QHSYGKUGFLDHTC-UHFFFAOYSA-N 0.000 claims 1
- LGNWUOPUOAUJEX-UHFFFAOYSA-N 3-[2-[[1-(4-methoxy-2,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C1=C(C)C(OC)=CC(C)=C1C(CC(C)C)NC(=O)C1=CC(COC=2C=CC=CC=2)=CC=C1CCC(O)=O LGNWUOPUOAUJEX-UHFFFAOYSA-N 0.000 claims 1
- YNYUWURHWWPLDJ-UHFFFAOYSA-N 3-[2-[[1-(4-methoxy-3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C1=C(C)C(OC)=C(C)C=C1C(CC(C)C)NC(=O)C1=CC(COC=2C=CC=CC=2)=CC=C1CCC(O)=O YNYUWURHWWPLDJ-UHFFFAOYSA-N 0.000 claims 1
- YZYXNEKGJISLEM-UHFFFAOYSA-N 3-[2-[[1-(4-methoxy-3-methylphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C1=C(C)C(OC)=CC=C1C(CC(C)C)NC(=O)C1=CC(COC=2C=CC=CC=2)=CC=C1CCC(O)=O YZYXNEKGJISLEM-UHFFFAOYSA-N 0.000 claims 1
- MSUUCHWGFSNMJS-UHFFFAOYSA-N 3-[2-[[1-(4-tert-butylphenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(C(C)(C)C)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 MSUUCHWGFSNMJS-UHFFFAOYSA-N 0.000 claims 1
- SNBFTOWHOXXRMH-UHFFFAOYSA-N 3-[2-[[1-(7-methoxy-1,3-benzodioxol-5-yl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=2OCOC=2C(OC)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 SNBFTOWHOXXRMH-UHFFFAOYSA-N 0.000 claims 1
- SBEMDPFMTVUZFU-UHFFFAOYSA-N 3-[2-[[1-(7-methoxy-1,3-benzodioxol-5-yl)-3-methylbutyl]carbamoyl]-4-[(2-methylphenoxy)methyl]phenyl]propanoic acid Chemical compound C=1C=2OCOC=2C(OC)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1C SBEMDPFMTVUZFU-UHFFFAOYSA-N 0.000 claims 1
- ANNJOGOXCBZPCT-UHFFFAOYSA-N 3-[2-[[1-[2,4-bis(trifluoromethyl)phenyl]-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(C(F)(F)F)C=C(C(F)(F)F)C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 ANNJOGOXCBZPCT-UHFFFAOYSA-N 0.000 claims 1
- MBJPGWIGRNYVBN-UHFFFAOYSA-N 3-[2-[[1-[2-(difluoromethoxy)phenyl]-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC=C(OC(F)F)C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 MBJPGWIGRNYVBN-UHFFFAOYSA-N 0.000 claims 1
- VQOJRIZXOWLJHA-UHFFFAOYSA-N 3-[2-[[1-[2-chloro-5-(trifluoromethyl)phenyl]-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C(C(F)(F)F)=CC=C(Cl)C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 VQOJRIZXOWLJHA-UHFFFAOYSA-N 0.000 claims 1
- RVYSBFLMPFIFSH-UHFFFAOYSA-N 3-[2-[[1-[2-fluoro-4-(trifluoromethyl)phenyl]-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(C(F)(F)F)C=C(F)C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 RVYSBFLMPFIFSH-UHFFFAOYSA-N 0.000 claims 1
- BCXMRZSTEFBZED-UHFFFAOYSA-N 3-[2-[[1-[3,5-bis(trifluoromethyl)phenyl]-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C(C(F)(F)F)=CC(C(F)(F)F)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 BCXMRZSTEFBZED-UHFFFAOYSA-N 0.000 claims 1
- WIRJDSFCSUNLAH-UHFFFAOYSA-N 3-[2-[[1-[3-fluoro-4-(trifluoromethyl)phenyl]-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(C(F)(F)F)C(F)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 WIRJDSFCSUNLAH-UHFFFAOYSA-N 0.000 claims 1
- BCWGHIPBCVXSKW-UHFFFAOYSA-N 3-[2-[[1-[3-fluoro-5-(trifluoromethyl)phenyl]-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C(F)=CC(C(F)(F)F)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 BCWGHIPBCVXSKW-UHFFFAOYSA-N 0.000 claims 1
- ZQBRIRQPVDZDPX-UHFFFAOYSA-N 3-[2-[[1-[4-(diethylamino)phenyl]-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C1=CC(N(CC)CC)=CC=C1C(CC(C)C)NC(=O)C1=CC(COC=2C=CC=CC=2)=CC=C1CCC(O)=O ZQBRIRQPVDZDPX-UHFFFAOYSA-N 0.000 claims 1
- YZHPRZXXJIBSPL-UHFFFAOYSA-N 3-[2-[[1-[4-(difluoromethoxy)phenyl]-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(OC(F)F)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 YZHPRZXXJIBSPL-UHFFFAOYSA-N 0.000 claims 1
- HZMOOHGTLIHKLF-UHFFFAOYSA-N 3-[2-[[1-[4-(dimethylamino)-2-methoxyphenyl]-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound COC1=CC(N(C)C)=CC=C1C(CC(C)C)NC(=O)C1=CC(COC=2C=CC=CC=2)=CC=C1CCC(O)=O HZMOOHGTLIHKLF-UHFFFAOYSA-N 0.000 claims 1
- LOLIKOKKROEJPZ-UHFFFAOYSA-N 3-[2-[[1-[4-(dimethylamino)phenyl]-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(N(C)C)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 LOLIKOKKROEJPZ-UHFFFAOYSA-N 0.000 claims 1
- HZDSMFLQHJHGKS-UHFFFAOYSA-N 3-[2-[[1-[4-fluoro-2-(trifluoromethyl)phenyl]-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(F)C=C(C(F)(F)F)C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 HZDSMFLQHJHGKS-UHFFFAOYSA-N 0.000 claims 1
- LBWGYQUCFCIDCC-UHFFFAOYSA-N 3-[2-[[2-(3,5-dimethylphenyl)-4-methylpentanoyl]amino]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)C(=O)NC(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 LBWGYQUCFCIDCC-UHFFFAOYSA-N 0.000 claims 1
- OXPHUQQUACDQPZ-UHFFFAOYSA-N 3-[2-[[2-(4-fluoro-3-methylphenyl)-4-methylpentanoyl]amino]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(F)C(C)=CC=1C(CC(C)C)C(=O)NC(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 OXPHUQQUACDQPZ-UHFFFAOYSA-N 0.000 claims 1
- HMPMQFFFVOYXLV-UHFFFAOYSA-N 3-[2-[[2-(7-methoxy-1,3-benzodioxol-5-yl)-4-methylpentanoyl]amino]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=2OCOC=2C(OC)=CC=1C(CC(C)C)C(=O)NC(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 HMPMQFFFVOYXLV-UHFFFAOYSA-N 0.000 claims 1
- NVAQBMXBXQWTSK-UHFFFAOYSA-N 3-[2-[[3-methyl-1-(1-methylpyrrol-2-yl)butyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=CN(C)C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 NVAQBMXBXQWTSK-UHFFFAOYSA-N 0.000 claims 1
- SEGSWGWHKANQFW-UHFFFAOYSA-N 3-[2-[[3-methyl-1-(2,3,4-trifluorophenyl)butyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(F)C(F)=C(F)C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 SEGSWGWHKANQFW-UHFFFAOYSA-N 0.000 claims 1
- ZRROQGSYCMOGCX-UHFFFAOYSA-N 3-[2-[[3-methyl-1-(2,3,4-trimethoxyphenyl)butyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound COC1=C(OC)C(OC)=CC=C1C(CC(C)C)NC(=O)C1=CC(COC=2C=CC=CC=2)=CC=C1CCC(O)=O ZRROQGSYCMOGCX-UHFFFAOYSA-N 0.000 claims 1
- BMSQNBJCZANFPS-UHFFFAOYSA-N 3-[2-[[3-methyl-1-(2,3,6-trifluorophenyl)butyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound FC=1C=CC(F)=C(F)C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 BMSQNBJCZANFPS-UHFFFAOYSA-N 0.000 claims 1
- DNMLDEPBMLGWSY-UHFFFAOYSA-N 3-[2-[[3-methyl-1-(2,4,5-trifluorophenyl)butyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C(F)=C(F)C=C(F)C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 DNMLDEPBMLGWSY-UHFFFAOYSA-N 0.000 claims 1
- XYYNJBFYOINIEO-UHFFFAOYSA-N 3-[2-[[3-methyl-1-(2,4,5-trimethoxyphenyl)butyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C1=C(OC)C(OC)=CC(OC)=C1C(CC(C)C)NC(=O)C1=CC(COC=2C=CC=CC=2)=CC=C1CCC(O)=O XYYNJBFYOINIEO-UHFFFAOYSA-N 0.000 claims 1
- DNYAKQOCHZBHCM-UHFFFAOYSA-N 3-[2-[[3-methyl-1-(2,4,6-trifluorophenyl)butyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound FC=1C=C(F)C=C(F)C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 DNYAKQOCHZBHCM-UHFFFAOYSA-N 0.000 claims 1
- VWAJGZMJLDKULL-UHFFFAOYSA-N 3-[2-[[3-methyl-1-(2-methylphenyl)butyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC=C(C)C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 VWAJGZMJLDKULL-UHFFFAOYSA-N 0.000 claims 1
- MRBVJMKSUKRWEO-UHFFFAOYSA-N 3-[2-[[3-methyl-1-(3,4,5-trifluorophenyl)butyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C(F)=C(F)C(F)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 MRBVJMKSUKRWEO-UHFFFAOYSA-N 0.000 claims 1
- KOSVUBTZPMOYMW-UHFFFAOYSA-N 3-[2-[[3-methyl-1-(3-methylphenyl)butyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 KOSVUBTZPMOYMW-UHFFFAOYSA-N 0.000 claims 1
- UDNRHJYCSWKDII-UHFFFAOYSA-N 3-[2-[[3-methyl-1-(3-methylthiophen-2-yl)butyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound S1C=CC(C)=C1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 UDNRHJYCSWKDII-UHFFFAOYSA-N 0.000 claims 1
- VAEAJSSUIUDENU-UHFFFAOYSA-N 3-[2-[[3-methyl-1-(3-propan-2-yloxyphenyl)butyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC(OC(C)C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 VAEAJSSUIUDENU-UHFFFAOYSA-N 0.000 claims 1
- VLHQZWGHSYIIBF-UHFFFAOYSA-N 3-[2-[[3-methyl-1-(3-propan-2-ylphenyl)butyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC(C(C)C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 VLHQZWGHSYIIBF-UHFFFAOYSA-N 0.000 claims 1
- CDBREVYLTWFNCI-UHFFFAOYSA-N 3-[2-[[3-methyl-1-(4-methylphenyl)butyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(C)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 CDBREVYLTWFNCI-UHFFFAOYSA-N 0.000 claims 1
- YODQSMIIGWCNDB-UHFFFAOYSA-N 3-[2-[[3-methyl-1-(4-methylsulfanylphenyl)butyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C1=CC(SC)=CC=C1C(CC(C)C)NC(=O)C1=CC(COC=2C=CC=CC=2)=CC=C1CCC(O)=O YODQSMIIGWCNDB-UHFFFAOYSA-N 0.000 claims 1
- UJHWRMXQWOBSSL-UHFFFAOYSA-N 3-[2-[[3-methyl-1-(4-methylsulfonylphenyl)butyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(S(C)(=O)=O)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 UJHWRMXQWOBSSL-UHFFFAOYSA-N 0.000 claims 1
- ZBXQLIMRMDOCOY-UHFFFAOYSA-N 3-[2-[[3-methyl-1-(4-propan-2-yloxyphenyl)butyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(OC(C)C)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 ZBXQLIMRMDOCOY-UHFFFAOYSA-N 0.000 claims 1
- DXLHKKYGJNHXGA-UHFFFAOYSA-N 3-[2-[[3-methyl-1-(4-propoxyphenyl)butyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C1=CC(OCCC)=CC=C1C(CC(C)C)NC(=O)C1=CC(COC=2C=CC=CC=2)=CC=C1CCC(O)=O DXLHKKYGJNHXGA-UHFFFAOYSA-N 0.000 claims 1
- NONHGMUHQXKIDT-UHFFFAOYSA-N 3-[2-[[3-methyl-1-(4-propylphenyl)butyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C1=CC(CCC)=CC=C1C(CC(C)C)NC(=O)C1=CC(COC=2C=CC=CC=2)=CC=C1CCC(O)=O NONHGMUHQXKIDT-UHFFFAOYSA-N 0.000 claims 1
- YTRYGGQQROFYEM-UHFFFAOYSA-N 3-[2-[[3-methyl-1-(4-pyrrolidin-1-ylphenyl)butyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(N2CCCC2)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 YTRYGGQQROFYEM-UHFFFAOYSA-N 0.000 claims 1
- JWYLVNMHBLFSPV-UHFFFAOYSA-N 3-[2-[[3-methyl-1-(5-methylfuran-2-yl)butyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(C)OC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 JWYLVNMHBLFSPV-UHFFFAOYSA-N 0.000 claims 1
- JSGXNLHDYPBDFZ-UHFFFAOYSA-N 3-[2-[[3-methyl-1-[3-(trifluoromethoxy)phenyl]butyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC(OC(F)(F)F)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 JSGXNLHDYPBDFZ-UHFFFAOYSA-N 0.000 claims 1
- FJAJNPTVVSIQEH-UHFFFAOYSA-N 3-[2-[[3-methyl-1-[3-(trifluoromethyl)phenyl]butyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC(C(F)(F)F)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 FJAJNPTVVSIQEH-UHFFFAOYSA-N 0.000 claims 1
- RBGWFZMYXOTIIQ-UHFFFAOYSA-N 3-[2-[[3-methyl-1-[3-(trifluoromethylsulfanyl)phenyl]butyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC(SC(F)(F)F)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 RBGWFZMYXOTIIQ-UHFFFAOYSA-N 0.000 claims 1
- WNCPPUAOJHMPLY-UHFFFAOYSA-N 3-[2-[[3-methyl-1-[4-(2-methylpropyl)phenyl]butyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(CC(C)C)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 WNCPPUAOJHMPLY-UHFFFAOYSA-N 0.000 claims 1
- PCJFJHAHBDUYEM-UHFFFAOYSA-N 3-[2-[[3-methyl-1-[4-(trifluoromethoxy)phenyl]butyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(OC(F)(F)F)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 PCJFJHAHBDUYEM-UHFFFAOYSA-N 0.000 claims 1
- PUGHDSORZNLDBF-UHFFFAOYSA-N 3-[2-[[3-methyl-1-[4-(trifluoromethyl)phenyl]butyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(C(F)(F)F)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 PUGHDSORZNLDBF-UHFFFAOYSA-N 0.000 claims 1
- OMPTZZMKBIAISZ-UHFFFAOYSA-N 3-[2-[[3-methyl-1-[4-(trifluoromethylsulfanyl)phenyl]butyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C(SC(F)(F)F)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 OMPTZZMKBIAISZ-UHFFFAOYSA-N 0.000 claims 1
- WIMPNTXPARWKDR-UHFFFAOYSA-N 3-[2-[[4-(3,5-dimethylphenyl)oxan-4-yl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound CC1=CC(C)=CC(C2(CCOCC2)NC(=O)C=2C(=CC=C(COC=3C=CC=CC=3)C=2)CCC(O)=O)=C1 WIMPNTXPARWKDR-UHFFFAOYSA-N 0.000 claims 1
- NYXBUKAYAWANAO-UHFFFAOYSA-N 3-[2-[[4-(3,5-dimethylphenyl)oxan-4-yl]carbamoyl]-4-[(2,3,6-trifluorophenyl)methoxy]phenyl]propanoic acid Chemical compound CC1=CC(C)=CC(C2(CCOCC2)NC(=O)C=2C(=CC=C(OCC=3C(=C(F)C=CC=3F)F)C=2)CCC(O)=O)=C1 NYXBUKAYAWANAO-UHFFFAOYSA-N 0.000 claims 1
- YDMJZCFQDQEZBP-UHFFFAOYSA-N 3-[2-[[4-(3,5-dimethylphenyl)oxan-4-yl]carbamoyl]-4-[(2-fluorophenoxy)methyl]phenyl]propanoic acid Chemical compound CC1=CC(C)=CC(C2(CCOCC2)NC(=O)C=2C(=CC=C(COC=3C(=CC=CC=3)F)C=2)CCC(O)=O)=C1 YDMJZCFQDQEZBP-UHFFFAOYSA-N 0.000 claims 1
- WPHCNHAWHMZFOG-UHFFFAOYSA-N 3-[2-[[4-(3,5-dimethylphenyl)oxan-4-yl]carbamoyl]-4-[(3-fluorophenoxy)methyl]phenyl]propanoic acid Chemical compound CC1=CC(C)=CC(C2(CCOCC2)NC(=O)C=2C(=CC=C(COC=3C=C(F)C=CC=3)C=2)CCC(O)=O)=C1 WPHCNHAWHMZFOG-UHFFFAOYSA-N 0.000 claims 1
- QRSGHEBBKFTPGF-UHFFFAOYSA-N 3-[2-[[4-(3,5-dimethylphenyl)oxan-4-yl]carbamoyl]-4-phenoxyphenyl]propanoic acid Chemical compound CC1=CC(C)=CC(C2(CCOCC2)NC(=O)C=2C(=CC=C(OC=3C=CC=CC=3)C=2)CCC(O)=O)=C1 QRSGHEBBKFTPGF-UHFFFAOYSA-N 0.000 claims 1
- XKPSVNZHVNYSJC-UHFFFAOYSA-N 3-[2-[[4-(3,5-dimethylphenyl)oxan-4-yl]carbamoyl]-4-phenylmethoxyphenyl]propanoic acid Chemical compound CC1=CC(C)=CC(C2(CCOCC2)NC(=O)C=2C(=CC=C(OCC=3C=CC=CC=3)C=2)CCC(O)=O)=C1 XKPSVNZHVNYSJC-UHFFFAOYSA-N 0.000 claims 1
- QMNOODWYPPBPIS-UHFFFAOYSA-N 3-[2-[acetyl(2-naphthalen-2-ylethyl)amino]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C2C=CC=CC2=CC=1CCN(C(=O)C)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 QMNOODWYPPBPIS-UHFFFAOYSA-N 0.000 claims 1
- SIHHLWURWZEKNJ-UHFFFAOYSA-N 3-[2-[benzyl(methyl)carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C(COC=2C=CC=CC=2)=CC=C(CCC(O)=O)C=1C(=O)N(C)CC1=CC=CC=C1 SIHHLWURWZEKNJ-UHFFFAOYSA-N 0.000 claims 1
- RQKHQNLMHCSEEH-UHFFFAOYSA-N 3-[2-[benzyl(propyl)carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C(COC=2C=CC=CC=2)=CC=C(CCC(O)=O)C=1C(=O)N(CCC)CC1=CC=CC=C1 RQKHQNLMHCSEEH-UHFFFAOYSA-N 0.000 claims 1
- KSYMKBPLMSHJHL-UHFFFAOYSA-N 3-[2-[methyl(2-naphthalen-2-ylethyl)amino]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=C2C=CC=CC2=CC=1CCN(C)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 KSYMKBPLMSHJHL-UHFFFAOYSA-N 0.000 claims 1
- LBNXXEZWDPBVQQ-UHFFFAOYSA-N 3-[2-methyl-1-(2-naphthalen-1-ylpropanoyl)indol-3-yl]propanoic acid Chemical compound C1=CC=C2C(C(C(=O)N3C4=CC=CC=C4C(CCC(O)=O)=C3C)C)=CC=CC2=C1 LBNXXEZWDPBVQQ-UHFFFAOYSA-N 0.000 claims 1
- BFDVDVPVAPELGW-UHFFFAOYSA-N 3-[3-[(3-cyanophenoxy)methyl]-5-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]prop-2-enoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C=C(C=CC(O)=O)C=1)=CC=1COC1=CC=CC(C#N)=C1 BFDVDVPVAPELGW-UHFFFAOYSA-N 0.000 claims 1
- AMIRJENPUCHTAI-UHFFFAOYSA-N 3-[3-[(3-cyanophenoxy)methyl]-5-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C=1)=CC(CCC(O)=O)=CC=1COC1=CC=CC(C#N)=C1 AMIRJENPUCHTAI-UHFFFAOYSA-N 0.000 claims 1
- LAFLTELFOGAPHG-UHFFFAOYSA-N 3-[3-[2-[2-[(3-methoxybenzoyl)amino]ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoylsulfamoyl]benzoic acid Chemical compound COC1=CC=CC(C(=O)NCCOC=2C(=CC=C(CN3N=CC=C3)C=2)CCC(=O)NS(=O)(=O)C=2C=C(C=CC=2)C(O)=O)=C1 LAFLTELFOGAPHG-UHFFFAOYSA-N 0.000 claims 1
- KXWLASZYJBRHBP-UHFFFAOYSA-N 3-[3-benzyl-1-[2-[(3-methyl-1-phenylbutyl)amino]-2-oxoethyl]indol-7-yl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)CN(C1=C(CCC(O)=O)C=CC=C11)C=C1CC1=CC=CC=C1 KXWLASZYJBRHBP-UHFFFAOYSA-N 0.000 claims 1
- PHPAHRYXYZGRHM-UHFFFAOYSA-N 3-[3-methyl-2-[(3-methyl-1-phenylbutyl)carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=C(C)C=1COC1=CC=CC=C1 PHPAHRYXYZGRHM-UHFFFAOYSA-N 0.000 claims 1
- NDRAQHPMNLFHOX-UHFFFAOYSA-N 3-[4-(1,3-benzodioxol-2-yl)-2-[(3-methyl-1-phenylbutyl)carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C2OC3=CC=CC=C3O2)=CC=C(CCC(O)=O)C=1C(=O)NC(CC(C)C)C1=CC=CC=C1 NDRAQHPMNLFHOX-UHFFFAOYSA-N 0.000 claims 1
- CIZQJGICNJWQIH-UHFFFAOYSA-N 3-[4-(1,3-benzothiazol-2-yl)-2-[(3-methyl-1-phenylbutyl)carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C=2SC3=CC=CC=C3N=2)=CC=C(CCC(O)=O)C=1C(=O)NC(CC(C)C)C1=CC=CC=C1 CIZQJGICNJWQIH-UHFFFAOYSA-N 0.000 claims 1
- KLQWYXKBABMMAF-AREMUKBSSA-N 3-[4-(1,3-benzothiazol-2-yloxy)-2-[[(1r)-1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C1([C@H](NC(=O)C=2C(=CC=C(OC=3SC4=CC=CC=C4N=3)C=2)CCC(O)=O)CC(C)C)=CC(C)=CC(C)=C1 KLQWYXKBABMMAF-AREMUKBSSA-N 0.000 claims 1
- AEFBAWKFLQANRG-UHFFFAOYSA-N 3-[4-(1,3-dihydroisoindol-2-yl)-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(N2CC3=CC=CC=C3C2)=CC=C(CCC(O)=O)C=1C(=O)NC(CC(C)C)C1=CC(C)=CC(C)=C1 AEFBAWKFLQANRG-UHFFFAOYSA-N 0.000 claims 1
- LDYXJSOOTOECNS-LJQANCHMSA-N 3-[4-(2-cyanophenoxy)-2-[[(1r)-1-naphthalen-1-ylethyl]carbamoyl]phenyl]propanoic acid Chemical compound N([C@H](C)C=1C2=CC=CC=C2C=CC=1)C(=O)C(C(=CC=1)CCC(O)=O)=CC=1OC1=CC=CC=C1C#N LDYXJSOOTOECNS-LJQANCHMSA-N 0.000 claims 1
- ZOMWUFZSNAHRRZ-UHFFFAOYSA-N 3-[4-(2-hydroxypropan-2-yl)-2-(2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound CC(C)(O)C1=CC=C(CCC(O)=O)C(OCCC=2C=C3C=CC=CC3=CC=2)=C1 ZOMWUFZSNAHRRZ-UHFFFAOYSA-N 0.000 claims 1
- SGINURJKIURAEG-HXUWFJFHSA-N 3-[4-(4-methylphenoxy)-2-[[(1r)-1-naphthalen-1-ylethyl]carbamoyl]phenyl]propanoic acid Chemical compound N([C@H](C)C=1C2=CC=CC=C2C=CC=1)C(=O)C(C(=CC=1)CCC(O)=O)=CC=1OC1=CC=C(C)C=C1 SGINURJKIURAEG-HXUWFJFHSA-N 0.000 claims 1
- KMFYNEKPXZYHGP-UHFFFAOYSA-N 3-[4-(anilinomethyl)-2-[(3-methyl-1-phenylbutyl)carbamoyl]phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1CNC1=CC=CC=C1 KMFYNEKPXZYHGP-UHFFFAOYSA-N 0.000 claims 1
- SEYCIWHNRIBEJD-UHFFFAOYSA-N 3-[4-(anilinomethyl)-2-[2-(4-fluoronaphthalen-1-yl)propanoylamino]phenyl]propanoic acid Chemical compound C=1C=C(F)C2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCC(O)=O)=CC=1CNC1=CC=CC=C1 SEYCIWHNRIBEJD-UHFFFAOYSA-N 0.000 claims 1
- UWVXHAYBGOXRDD-UHFFFAOYSA-N 3-[4-(benzenesulfonamido)-2-(2-naphthalen-2-ylethoxy)phenyl]-n-(3,4-difluorophenyl)sulfonylpropanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1NS(=O)(=O)C1=CC=CC=C1 UWVXHAYBGOXRDD-UHFFFAOYSA-N 0.000 claims 1
- YYMVTPBDYRKCFO-UHFFFAOYSA-N 3-[4-(benzenesulfonamido)-2-(2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound C1=C(OCCC=2C=C3C=CC=CC3=CC=2)C(CCC(=O)O)=CC=C1NS(=O)(=O)C1=CC=CC=C1 YYMVTPBDYRKCFO-UHFFFAOYSA-N 0.000 claims 1
- SOGRUFQYBBNFJH-UHFFFAOYSA-N 3-[4-(benzenesulfonamido)-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1NS(=O)(=O)C1=CC=CC=C1 SOGRUFQYBBNFJH-UHFFFAOYSA-N 0.000 claims 1
- RPCBDZVVYOZBJB-UHFFFAOYSA-N 3-[4-(benzenesulfonylmethyl)-2-(2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound C1=C(OCCC=2C=C3C=CC=CC3=CC=2)C(CCC(=O)O)=CC=C1CS(=O)(=O)C1=CC=CC=C1 RPCBDZVVYOZBJB-UHFFFAOYSA-N 0.000 claims 1
- REANRJAHIZZARG-UHFFFAOYSA-N 3-[4-(benzenesulfonyloxy)-2-[(3-methyl-1-phenylbutyl)carbamoyl]phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OS(=O)(=O)C1=CC=CC=C1 REANRJAHIZZARG-UHFFFAOYSA-N 0.000 claims 1
- BOOKTQJOYNLCJP-UHFFFAOYSA-N 3-[4-(benzimidazol-1-ylmethyl)-2-(2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound C1=CC=CC2=CC(CCOC3=CC(CN4C5=CC=CC=C5N=C4)=CC=C3CCC(=O)O)=CC=C21 BOOKTQJOYNLCJP-UHFFFAOYSA-N 0.000 claims 1
- ZZVGYKBTLBPNGE-UHFFFAOYSA-N 3-[4-(benzylamino)-2-[(3-methyl-1-phenylbutyl)carbamoyl]phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1NCC1=CC=CC=C1 ZZVGYKBTLBPNGE-UHFFFAOYSA-N 0.000 claims 1
- JGJHXWVYHLSGIN-UHFFFAOYSA-N 3-[4-(benzylamino)-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1NCC1=CC=CC=C1 JGJHXWVYHLSGIN-UHFFFAOYSA-N 0.000 claims 1
- CWRWZCDSFHLPLX-UHFFFAOYSA-N 3-[4-(cyclopropylmethoxymethyl)-2-[(3-methyl-1-phenylbutyl)carbamoyl]phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COCC1CC1 CWRWZCDSFHLPLX-UHFFFAOYSA-N 0.000 claims 1
- RIOSLPMQWIWWGJ-UHFFFAOYSA-N 3-[4-(dibenzylamino)-2-[(3-methyl-1-phenylbutyl)carbamoyl]phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1N(CC=1C=CC=CC=1)CC1=CC=CC=C1 RIOSLPMQWIWWGJ-UHFFFAOYSA-N 0.000 claims 1
- OIWBEJCANFGXST-UHFFFAOYSA-N 3-[4-(hydroxymethyl)-2-(2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound OCC1=CC=C(CCC(O)=O)C(OCCC=2C=C3C=CC=CC3=CC=2)=C1 OIWBEJCANFGXST-UHFFFAOYSA-N 0.000 claims 1
- SKHHNLRRBHZLMQ-UHFFFAOYSA-N 3-[4-(indol-1-ylmethyl)-2-[(3-methyl-1-phenylbutyl)carbamoyl]phenyl]propanoic acid Chemical compound C=1C(CN2C3=CC=CC=C3C=C2)=CC=C(CCC(O)=O)C=1C(=O)NC(CC(C)C)C1=CC=CC=C1 SKHHNLRRBHZLMQ-UHFFFAOYSA-N 0.000 claims 1
- PADJNPSSIDADIU-UHFFFAOYSA-N 3-[4-(methanesulfonamido)-2-[(3-methyl-1-phenylbutyl)carbamoyl]phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C1=CC(NS(C)(=O)=O)=CC=C1CCC(O)=O PADJNPSSIDADIU-UHFFFAOYSA-N 0.000 claims 1
- ZNHWXYVFCRSTRU-UHFFFAOYSA-N 3-[4-(methoxycarbonylamino)-2-[(3-methyl-1-phenylbutyl)carbamoyl]phenyl]propanoic acid Chemical compound COC(=O)NC1=CC=C(CCC(O)=O)C(C(=O)NC(CC(C)C)C=2C=CC=CC=2)=C1 ZNHWXYVFCRSTRU-UHFFFAOYSA-N 0.000 claims 1
- DWXRRYOVIQHBNP-UHFFFAOYSA-N 3-[4-(methoxymethyl)-2-[(3-methyl-1-phenylbutyl)carbamoyl]phenyl]propanoic acid Chemical compound COCC1=CC=C(CCC(O)=O)C(C(=O)NC(CC(C)C)C=2C=CC=CC=2)=C1 DWXRRYOVIQHBNP-UHFFFAOYSA-N 0.000 claims 1
- JPMYTILRJOOTLZ-UHFFFAOYSA-N 3-[4-(morpholin-4-ylmethyl)-2-(2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound C1=C(OCCC=2C=C3C=CC=CC3=CC=2)C(CCC(=O)O)=CC=C1CN1CCOCC1 JPMYTILRJOOTLZ-UHFFFAOYSA-N 0.000 claims 1
- BWFKJMIVJDOCKH-UHFFFAOYSA-N 3-[4-(phenoxymethyl)-2-(1-phenylbutylcarbamoyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CCC)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 BWFKJMIVJDOCKH-UHFFFAOYSA-N 0.000 claims 1
- ONYZBXNUJWRHLM-UHFFFAOYSA-N 3-[4-(phenoxymethyl)-2-(1-phenylethylcarbamoyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 ONYZBXNUJWRHLM-UHFFFAOYSA-N 0.000 claims 1
- ALZVZLLGVSCBSU-UHFFFAOYSA-N 3-[4-(phenoxymethyl)-2-(1-phenylpropan-2-ylcarbamoyl)phenyl]propanoic acid Chemical compound C=1C(COC=2C=CC=CC=2)=CC=C(CCC(O)=O)C=1C(=O)NC(C)CC1=CC=CC=C1 ALZVZLLGVSCBSU-UHFFFAOYSA-N 0.000 claims 1
- BUWAGMJUQPCWLH-UHFFFAOYSA-N 3-[4-(phenoxymethyl)-2-(1-phenylpropylcarbamoyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 BUWAGMJUQPCWLH-UHFFFAOYSA-N 0.000 claims 1
- FAIWHEKWQGRGFV-UHFFFAOYSA-N 3-[4-(phenoxymethyl)-2-(2-phenylbutanoylamino)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC)C(=O)NC(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 FAIWHEKWQGRGFV-UHFFFAOYSA-N 0.000 claims 1
- RSTJOTNIYSIDGK-UHFFFAOYSA-N 3-[4-(phenoxymethyl)-2-(2-phenylethoxy)phenyl]propanoic acid Chemical compound C1=C(OCCC=2C=CC=CC=2)C(CCC(=O)O)=CC=C1COC1=CC=CC=C1 RSTJOTNIYSIDGK-UHFFFAOYSA-N 0.000 claims 1
- BZUNQYCTNHWATL-UHFFFAOYSA-N 3-[4-(phenoxymethyl)-2-(2-phenylethylcarbamoyl)phenyl]propanoic acid Chemical compound C1=C(C(=O)NCCC=2C=CC=CC=2)C(CCC(=O)O)=CC=C1COC1=CC=CC=C1 BZUNQYCTNHWATL-UHFFFAOYSA-N 0.000 claims 1
- ZJGVWOCAJZWFKS-UHFFFAOYSA-N 3-[4-(phenoxymethyl)-2-(2-phenylpentanoylamino)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CCC)C(=O)NC(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 ZJGVWOCAJZWFKS-UHFFFAOYSA-N 0.000 claims 1
- MWUAQJJXLKDAGG-UHFFFAOYSA-N 3-[4-(phenoxymethyl)-2-(2-phenylpropanoylamino)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(C)C(=O)NC(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 MWUAQJJXLKDAGG-UHFFFAOYSA-N 0.000 claims 1
- GMWBIXYKNBHCMQ-UHFFFAOYSA-N 3-[4-(phenoxymethyl)-2-(2-phenylpropylcarbamoyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(C)CNC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1 GMWBIXYKNBHCMQ-UHFFFAOYSA-N 0.000 claims 1
- DZESJNWNQOUTOI-UHFFFAOYSA-N 3-[4-(phenoxymethyl)-2-(3-phenylmorpholine-4-carbonyl)phenyl]propanoic acid Chemical compound C1=C(C(=O)N2C(COCC2)C=2C=CC=CC=2)C(CCC(=O)O)=CC=C1COC1=CC=CC=C1 DZESJNWNQOUTOI-UHFFFAOYSA-N 0.000 claims 1
- VVSGZNJSYRFNQC-UHFFFAOYSA-N 3-[4-(phenoxymethyl)-2-(3-phenylpropoxy)phenyl]propanoic acid Chemical compound C1=C(OCCCC=2C=CC=CC=2)C(CCC(=O)O)=CC=C1COC1=CC=CC=C1 VVSGZNJSYRFNQC-UHFFFAOYSA-N 0.000 claims 1
- SBLNJMYTRDXYFK-UHFFFAOYSA-N 3-[4-(phenoxymethyl)-2-(4-phenoxypiperidine-1-carbonyl)phenyl]propanoic acid Chemical compound C1=C(C(=O)N2CCC(CC2)OC=2C=CC=CC=2)C(CCC(=O)O)=CC=C1COC1=CC=CC=C1 SBLNJMYTRDXYFK-UHFFFAOYSA-N 0.000 claims 1
- VNHPGGOCKJZACX-UHFFFAOYSA-N 3-[4-(phenoxymethyl)-2-(4-phenylbutoxy)phenyl]propanoic acid Chemical compound C1=C(OCCCCC=2C=CC=CC=2)C(CCC(=O)O)=CC=C1COC1=CC=CC=C1 VNHPGGOCKJZACX-UHFFFAOYSA-N 0.000 claims 1
- YYDDLVYQIXLOFF-UHFFFAOYSA-N 3-[4-(phenoxymethyl)-2-(phenylcarbamoyl)phenyl]propanoic acid Chemical compound C1=C(C(=O)NC=2C=CC=CC=2)C(CCC(=O)O)=CC=C1COC1=CC=CC=C1 YYDDLVYQIXLOFF-UHFFFAOYSA-N 0.000 claims 1
- YKIXGFKMFKPFLY-UHFFFAOYSA-N 3-[4-(phenoxymethyl)-2-(quinolin-4-ylmethylcarbamoyl)phenyl]propanoic acid Chemical compound C1=C(C(=O)NCC=2C3=CC=CC=C3N=CC=2)C(CCC(=O)O)=CC=C1COC1=CC=CC=C1 YKIXGFKMFKPFLY-UHFFFAOYSA-N 0.000 claims 1
- JAMRGFFZHRIYRD-UHFFFAOYSA-N 3-[4-(pyrazol-1-ylmethyl)-2-(2-thiophen-2-ylethoxy)phenyl]propanoic acid Chemical compound C1=C(OCCC=2SC=CC=2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 JAMRGFFZHRIYRD-UHFFFAOYSA-N 0.000 claims 1
- CWQHCHGWDQTRSY-UHFFFAOYSA-N 3-[4-(pyrazol-1-ylmethyl)-2-(2-thiophen-3-ylethoxy)phenyl]propanoic acid Chemical compound C1=C(OCCC2=CSC=C2)C(CCC(=O)O)=CC=C1CN1C=CC=N1 CWQHCHGWDQTRSY-UHFFFAOYSA-N 0.000 claims 1
- PDNZLRVETPTCJR-UHFFFAOYSA-N 3-[4-[(1-methylimidazol-2-yl)sulfanylmethyl]-2-[(3-methyl-1-phenylbutyl)carbamoyl]phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1CSC1=NC=CN1C PDNZLRVETPTCJR-UHFFFAOYSA-N 0.000 claims 1
- APHBRNQRHHSZCW-UHFFFAOYSA-N 3-[4-[(2,3-difluoro-4-methylphenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=C(C)C(F)=C1F APHBRNQRHHSZCW-UHFFFAOYSA-N 0.000 claims 1
- DAPQMHVIKFLWDP-UHFFFAOYSA-N 3-[4-[(2,3-difluorophenoxy)methyl]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC(F)=C1F DAPQMHVIKFLWDP-UHFFFAOYSA-N 0.000 claims 1
- MWRBUZSZITXELN-UHFFFAOYSA-N 3-[4-[(2,3-difluorophenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=CC(F)=C1F MWRBUZSZITXELN-UHFFFAOYSA-N 0.000 claims 1
- FYBAHLWROKCLIB-UHFFFAOYSA-N 3-[4-[(2,3-dimethoxyphenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound COC1=CC=CC(COC=2C=C(C(CCC(O)=O)=CC=2)C(=O)NC(CC(C)C)C=2C=C(C)C=C(C)C=2)=C1OC FYBAHLWROKCLIB-UHFFFAOYSA-N 0.000 claims 1
- HOMFCSJQXCDBSC-UHFFFAOYSA-N 3-[4-[(2,3-dimethylphenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=CC(C)=C1C HOMFCSJQXCDBSC-UHFFFAOYSA-N 0.000 claims 1
- ANXDYLMRCATVOP-HHHXNRCGSA-N 3-[4-[(2,4-difluorophenoxy)methyl]-2-[[(1r)-1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound N([C@H](CC(C)C)C=1C=C(C)C=C(C)C=1)C(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=C(F)C=C1F ANXDYLMRCATVOP-HHHXNRCGSA-N 0.000 claims 1
- ANXDYLMRCATVOP-UHFFFAOYSA-N 3-[4-[(2,4-difluorophenoxy)methyl]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=C(F)C=C1F ANXDYLMRCATVOP-UHFFFAOYSA-N 0.000 claims 1
- RWQSKNCJVSFDQR-UHFFFAOYSA-N 3-[4-[(2,4-difluorophenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=C(F)C=C1F RWQSKNCJVSFDQR-UHFFFAOYSA-N 0.000 claims 1
- RLWOFQGRKDQZTH-UHFFFAOYSA-N 3-[4-[(2,4-dimethylphenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=C(C)C=C1C RLWOFQGRKDQZTH-UHFFFAOYSA-N 0.000 claims 1
- JXQCWQARWIDLTK-UHFFFAOYSA-N 3-[4-[(2,5-dichlorophenoxy)methyl]-2-(naphthalen-1-ylmethylcarbamoyl)phenyl]propanoic acid Chemical compound C1=C(C(=O)NCC=2C3=CC=CC=C3C=CC=2)C(CCC(=O)O)=CC=C1COC1=CC(Cl)=CC=C1Cl JXQCWQARWIDLTK-UHFFFAOYSA-N 0.000 claims 1
- LNSVYJAGCGWYIA-UHFFFAOYSA-N 3-[4-[(2,5-dichlorophenoxy)methyl]-2-[[4-(3,5-dimethylphenyl)oxan-4-yl]carbamoyl]phenyl]propanoic acid Chemical compound CC1=CC(C)=CC(C2(CCOCC2)NC(=O)C=2C(=CC=C(COC=3C(=CC=C(Cl)C=3)Cl)C=2)CCC(O)=O)=C1 LNSVYJAGCGWYIA-UHFFFAOYSA-N 0.000 claims 1
- CFJYVEVOBAHNGZ-UHFFFAOYSA-N 3-[4-[(2,5-diethoxyphenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound CCOC1=CC=C(OCC)C(COC=2C=C(C(CCC(O)=O)=CC=2)C(=O)NC(CC(C)C)C=2C=C(C)C=C(C)C=2)=C1 CFJYVEVOBAHNGZ-UHFFFAOYSA-N 0.000 claims 1
- HBYFBACSFISHGZ-UHFFFAOYSA-N 3-[4-[(2,5-difluorophenoxy)methyl]-2-[(3-methyl-1-naphthalen-1-ylbutyl)carbamoyl]phenyl]propanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC(F)=CC=C1F HBYFBACSFISHGZ-UHFFFAOYSA-N 0.000 claims 1
- DRMBYGMYALWGEU-UHFFFAOYSA-N 3-[4-[(2,5-difluorophenoxy)methyl]-2-[(4-naphthalen-1-yloxan-4-yl)carbamoyl]phenyl]propanoic acid Chemical compound C1=C(C(=O)NC2(CCOCC2)C=2C3=CC=CC=C3C=CC=2)C(CCC(=O)O)=CC=C1COC1=CC(F)=CC=C1F DRMBYGMYALWGEU-UHFFFAOYSA-N 0.000 claims 1
- WJWSOMYLMUTCOD-HHHXNRCGSA-N 3-[4-[(2,5-difluorophenoxy)methyl]-2-[[(1r)-1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound N([C@H](CC(C)C)C=1C=C(C)C=C(C)C=1)C(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC(F)=CC=C1F WJWSOMYLMUTCOD-HHHXNRCGSA-N 0.000 claims 1
- WJWSOMYLMUTCOD-UHFFFAOYSA-N 3-[4-[(2,5-difluorophenoxy)methyl]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC(F)=CC=C1F WJWSOMYLMUTCOD-UHFFFAOYSA-N 0.000 claims 1
- ZJEPVDJGRFWUSE-UHFFFAOYSA-N 3-[4-[(2,5-difluorophenoxy)methyl]-2-[[1-(3,5-dimethylphenyl)cyclohexyl]carbamoyl]phenyl]propanoic acid Chemical compound CC1=CC(C)=CC(C2(CCCCC2)NC(=O)C=2C(=CC=C(COC=3C(=CC=C(F)C=3)F)C=2)CCC(O)=O)=C1 ZJEPVDJGRFWUSE-UHFFFAOYSA-N 0.000 claims 1
- AFDWETHXMODYTI-UHFFFAOYSA-N 3-[4-[(2,5-difluorophenoxy)methyl]-2-[[4-(3,5-dimethylphenyl)-1-ethylpiperidin-4-yl]carbamoyl]phenyl]propanoic acid Chemical compound C1CN(CC)CCC1(C=1C=C(C)C=C(C)C=1)NC(=O)C1=CC(COC=2C(=CC=C(F)C=2)F)=CC=C1CCC(O)=O AFDWETHXMODYTI-UHFFFAOYSA-N 0.000 claims 1
- LSAATAPZGYBHKP-UHFFFAOYSA-N 3-[4-[(2,5-difluorophenoxy)methyl]-2-[[4-(3,5-dimethylphenyl)-1-methylpiperidin-4-yl]carbamoyl]phenyl]propanoic acid Chemical compound C1CN(C)CCC1(C=1C=C(C)C=C(C)C=1)NC(=O)C1=CC(COC=2C(=CC=C(F)C=2)F)=CC=C1CCC(O)=O LSAATAPZGYBHKP-UHFFFAOYSA-N 0.000 claims 1
- PXSJAAJSWKHDTA-UHFFFAOYSA-N 3-[4-[(2,5-difluorophenoxy)methyl]-2-[[4-(3,5-dimethylphenyl)-1-methylsulfonylpiperidin-4-yl]carbamoyl]phenyl]propanoic acid Chemical compound CC1=CC(C)=CC(C2(CCN(CC2)S(C)(=O)=O)NC(=O)C=2C(=CC=C(COC=3C(=CC=C(F)C=3)F)C=2)CCC(O)=O)=C1 PXSJAAJSWKHDTA-UHFFFAOYSA-N 0.000 claims 1
- NMLAXFBPYJBZIC-UHFFFAOYSA-N 3-[4-[(2,5-difluorophenoxy)methyl]-2-[[4-(3,5-dimethylphenyl)-2,6-dimethylheptan-4-yl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC(F)=CC=C1F NMLAXFBPYJBZIC-UHFFFAOYSA-N 0.000 claims 1
- RGTSUOWFOXNMOT-UHFFFAOYSA-N 3-[4-[(2,5-difluorophenoxy)methyl]-2-[[4-(3-methylphenyl)oxan-4-yl]carbamoyl]phenyl]propanoic acid Chemical compound CC1=CC=CC(C2(CCOCC2)NC(=O)C=2C(=CC=C(COC=3C(=CC=C(F)C=3)F)C=2)CCC(O)=O)=C1 RGTSUOWFOXNMOT-UHFFFAOYSA-N 0.000 claims 1
- FSHMKQQPHJSZCT-UHFFFAOYSA-N 3-[4-[(2,5-difluorophenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC(F)=CC=C1F FSHMKQQPHJSZCT-UHFFFAOYSA-N 0.000 claims 1
- UQGHEEWLKXFVCL-UHFFFAOYSA-N 3-[4-[(2,5-dimethylphenoxy)methyl]-2-(naphthalen-1-ylmethylcarbamoyl)phenyl]propanoic acid Chemical compound CC1=CC=C(C)C(OCC=2C=C(C(CCC(O)=O)=CC=2)C(=O)NCC=2C3=CC=CC=C3C=CC=2)=C1 UQGHEEWLKXFVCL-UHFFFAOYSA-N 0.000 claims 1
- CZGCGANYIFZAMH-UHFFFAOYSA-N 3-[4-[(2,5-dimethylphenoxy)methyl]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC(C)=CC=C1C CZGCGANYIFZAMH-UHFFFAOYSA-N 0.000 claims 1
- PJSHBLRXNSSICV-UHFFFAOYSA-N 3-[4-[(2,5-dimethylphenoxy)methyl]-2-[[4-(3,5-dimethylphenyl)oxan-4-yl]carbamoyl]phenyl]propanoic acid Chemical compound CC1=CC=C(C)C(OCC=2C=C(C(CCC(O)=O)=CC=2)C(=O)NC2(CCOCC2)C=2C=C(C)C=C(C)C=2)=C1 PJSHBLRXNSSICV-UHFFFAOYSA-N 0.000 claims 1
- TZTBTJOTQVKRMN-UHFFFAOYSA-N 3-[4-[(2,5-dimethylphenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC(C)=CC=C1C TZTBTJOTQVKRMN-UHFFFAOYSA-N 0.000 claims 1
- YQXPHUWJIAKOMU-UHFFFAOYSA-N 3-[4-[(2,6-difluorophenoxy)methyl]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=C(F)C=CC=C1F YQXPHUWJIAKOMU-UHFFFAOYSA-N 0.000 claims 1
- OMCJZAUXZKPGLE-UHFFFAOYSA-N 3-[4-[(2,6-difluorophenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=C(F)C=CC=C1F OMCJZAUXZKPGLE-UHFFFAOYSA-N 0.000 claims 1
- XVZZTCNGTNXLBC-UHFFFAOYSA-N 3-[4-[(2,6-dimethylphenoxy)methyl]-2-(naphthalen-1-ylmethylcarbamoyl)phenyl]propanoic acid Chemical compound CC1=CC=CC(C)=C1OCC1=CC=C(CCC(O)=O)C(C(=O)NCC=2C3=CC=CC=C3C=CC=2)=C1 XVZZTCNGTNXLBC-UHFFFAOYSA-N 0.000 claims 1
- XELLZKIKROTBAC-UHFFFAOYSA-N 3-[4-[(2,6-dimethylphenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=C(C)C=CC=C1C XELLZKIKROTBAC-UHFFFAOYSA-N 0.000 claims 1
- VIDBRMMZNQYWAH-UHFFFAOYSA-N 3-[4-[(2-acetylphenoxy)methyl]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1C(C)=O VIDBRMMZNQYWAH-UHFFFAOYSA-N 0.000 claims 1
- DGGYRJLZDJUPRO-UHFFFAOYSA-N 3-[4-[(2-benzylphenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=CC=C1CC1=CC=CC=C1 DGGYRJLZDJUPRO-UHFFFAOYSA-N 0.000 claims 1
- FOISUJHPPYCWQY-UHFFFAOYSA-N 3-[4-[(2-chloro-3,6-difluorophenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=C(F)C=CC(F)=C1Cl FOISUJHPPYCWQY-UHFFFAOYSA-N 0.000 claims 1
- ZPPXRRDCLWMUPK-UHFFFAOYSA-N 3-[4-[(2-chloro-4,5-difluorophenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC(F)=C(F)C=C1Cl ZPPXRRDCLWMUPK-UHFFFAOYSA-N 0.000 claims 1
- UBYKQBZRDWDMTJ-UHFFFAOYSA-N 3-[4-[(2-chloro-4-fluorophenoxy)methyl]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=C(F)C=C1Cl UBYKQBZRDWDMTJ-UHFFFAOYSA-N 0.000 claims 1
- PYLYSLNSCWEYEK-UHFFFAOYSA-N 3-[4-[(2-chloro-4-fluorophenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=C(F)C=C1Cl PYLYSLNSCWEYEK-UHFFFAOYSA-N 0.000 claims 1
- MMORCVRQFIOOFM-UHFFFAOYSA-N 3-[4-[(2-chloro-5-fluorophenoxy)methyl]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC(F)=CC=C1Cl MMORCVRQFIOOFM-UHFFFAOYSA-N 0.000 claims 1
- DZEGRBBZNMUFAL-UHFFFAOYSA-N 3-[4-[(2-chloro-5-fluorophenoxy)methyl]-2-[[4-(3,5-dimethylphenyl)oxan-4-yl]carbamoyl]phenyl]propanoic acid Chemical compound CC1=CC(C)=CC(C2(CCOCC2)NC(=O)C=2C(=CC=C(COC=3C(=CC=C(F)C=3)Cl)C=2)CCC(O)=O)=C1 DZEGRBBZNMUFAL-UHFFFAOYSA-N 0.000 claims 1
- IJQNCXFQJPROGP-UHFFFAOYSA-N 3-[4-[(2-chloro-5-methylphenoxy)methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound CC1=CC=C(Cl)C(OCC=2C=C(OCCC=3C=C4C=CC=CC4=CC=3)C(CCC(O)=O)=CC=2)=C1 IJQNCXFQJPROGP-UHFFFAOYSA-N 0.000 claims 1
- KXWCVCSECXIIBD-UHFFFAOYSA-N 3-[4-[(2-chloro-5-methylphenoxy)methyl]-2-(2-phenylethoxy)phenyl]-n-(3,4-difluorophenyl)sulfonylpropanamide Chemical compound CC1=CC=C(Cl)C(OCC=2C=C(OCCC=3C=CC=CC=3)C(CCC(=O)NS(=O)(=O)C=3C=C(F)C(F)=CC=3)=CC=2)=C1 KXWCVCSECXIIBD-UHFFFAOYSA-N 0.000 claims 1
- CHDOHKBSIGORAN-UHFFFAOYSA-N 3-[4-[(2-chloro-5-methylphenoxy)methyl]-2-(naphthalen-1-ylmethylcarbamoyl)phenyl]propanoic acid Chemical compound CC1=CC=C(Cl)C(OCC=2C=C(C(CCC(O)=O)=CC=2)C(=O)NCC=2C3=CC=CC=C3C=CC=2)=C1 CHDOHKBSIGORAN-UHFFFAOYSA-N 0.000 claims 1
- ZLADZAALOCBYNE-UHFFFAOYSA-N 3-[4-[(2-chloro-5-methylphenoxy)methyl]-2-[1-(3,5-dimethylphenyl)ethylcarbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC(C)=CC=C1Cl ZLADZAALOCBYNE-UHFFFAOYSA-N 0.000 claims 1
- VFQBVKWRSXFFSR-UHFFFAOYSA-N 3-[4-[(2-chloro-5-methylphenoxy)methyl]-2-[[1-(3,5-dimethylphenyl)-2-methoxyethyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(COC)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC(C)=CC=C1Cl VFQBVKWRSXFFSR-UHFFFAOYSA-N 0.000 claims 1
- ZNYFYNGXSDCBPG-UHFFFAOYSA-N 3-[4-[(2-chloro-5-methylphenoxy)methyl]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC(C)=CC=C1Cl ZNYFYNGXSDCBPG-UHFFFAOYSA-N 0.000 claims 1
- CVARAYKIDYYIHT-UHFFFAOYSA-N 3-[4-[(2-chloro-5-methylphenoxy)methyl]-2-[[1-(4-fluoro-3-methylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C=C(F)C(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC(C)=CC=C1Cl CVARAYKIDYYIHT-UHFFFAOYSA-N 0.000 claims 1
- XIQILPPXODYYMZ-UHFFFAOYSA-N 3-[4-[(2-chloro-5-methylphenoxy)methyl]-2-[[1-(4-fluorophenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C=C(F)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC(C)=CC=C1Cl XIQILPPXODYYMZ-UHFFFAOYSA-N 0.000 claims 1
- RNUMSJIFAZEABI-UHFFFAOYSA-N 3-[4-[(2-chloro-5-methylphenoxy)methyl]-2-[[2-cyclopropyl-1-(3,5-dimethylphenyl)ethyl]carbamoyl]phenyl]propanoic acid Chemical compound CC1=CC=C(Cl)C(OCC=2C=C(C(CCC(O)=O)=CC=2)C(=O)NC(CC2CC2)C=2C=C(C)C=C(C)C=2)=C1 RNUMSJIFAZEABI-UHFFFAOYSA-N 0.000 claims 1
- FOAFRYRTDDXMFO-UHFFFAOYSA-N 3-[4-[(2-chloro-5-methylphenoxy)methyl]-2-[[4-(3,5-dimethylphenyl)oxan-4-yl]carbamoyl]phenyl]propanoic acid Chemical compound CC1=CC=C(Cl)C(OCC=2C=C(C(CCC(O)=O)=CC=2)C(=O)NC2(CCOCC2)C=2C=C(C)C=C(C)C=2)=C1 FOAFRYRTDDXMFO-UHFFFAOYSA-N 0.000 claims 1
- UVZITXSTOUKJSL-UHFFFAOYSA-N 3-[4-[(2-chloro-5-methylsulfanylphenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound CSC1=CC=C(Cl)C(COC=2C=C(C(CCC(O)=O)=CC=2)C(=O)NC(CC(C)C)C=2C=C(C)C=C(C)C=2)=C1 UVZITXSTOUKJSL-UHFFFAOYSA-N 0.000 claims 1
- DNFADWAZJSREQV-UHFFFAOYSA-N 3-[4-[(2-chloro-6-fluoro-3-methylphenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=C(F)C=CC(C)=C1Cl DNFADWAZJSREQV-UHFFFAOYSA-N 0.000 claims 1
- IWTANLHNQCSLQE-MUUNZHRXSA-N 3-[4-[(2-chloro-6-fluorophenyl)methoxy]-2-[[(1r)-1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound N([C@H](CC(C)C)C=1C=C(C)C=C(C)C=1)C(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=C(F)C=CC=C1Cl IWTANLHNQCSLQE-MUUNZHRXSA-N 0.000 claims 1
- IWTANLHNQCSLQE-UHFFFAOYSA-N 3-[4-[(2-chloro-6-fluorophenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=C(F)C=CC=C1Cl IWTANLHNQCSLQE-UHFFFAOYSA-N 0.000 claims 1
- YJALOEKYALBWNQ-UHFFFAOYSA-N 3-[4-[(2-chloro-6-fluorophenyl)methoxy]-2-[[4-(3,5-dimethylphenyl)oxan-4-yl]carbamoyl]phenyl]propanoic acid Chemical compound CC1=CC(C)=CC(C2(CCOCC2)NC(=O)C=2C(=CC=C(OCC=3C(=CC=CC=3F)Cl)C=2)CCC(O)=O)=C1 YJALOEKYALBWNQ-UHFFFAOYSA-N 0.000 claims 1
- KKZPZHANUCUCJH-UHFFFAOYSA-N 3-[4-[(2-chlorophenoxy)methyl]-2-(naphthalen-1-ylmethylcarbamoyl)phenyl]propanoic acid Chemical compound C1=C(C(=O)NCC=2C3=CC=CC=C3C=CC=2)C(CCC(=O)O)=CC=C1COC1=CC=CC=C1Cl KKZPZHANUCUCJH-UHFFFAOYSA-N 0.000 claims 1
- MXQJLUASAXQHCM-HHHXNRCGSA-N 3-[4-[(2-chlorophenoxy)methyl]-2-[[(1r)-1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound N([C@H](CC(C)C)C=1C=C(C)C=C(C)C=1)C(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1Cl MXQJLUASAXQHCM-HHHXNRCGSA-N 0.000 claims 1
- MXQJLUASAXQHCM-UHFFFAOYSA-N 3-[4-[(2-chlorophenoxy)methyl]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1Cl MXQJLUASAXQHCM-UHFFFAOYSA-N 0.000 claims 1
- VNDUMTTXGNXDGD-UHFFFAOYSA-N 3-[4-[(2-chlorophenoxy)methyl]-2-[[1-(4-fluorophenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C=C(F)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1Cl VNDUMTTXGNXDGD-UHFFFAOYSA-N 0.000 claims 1
- IWNDCXNXKFSZHP-UHFFFAOYSA-N 3-[4-[(2-chlorophenoxy)methyl]-2-[[4-(3,5-dimethylphenyl)oxan-4-yl]carbamoyl]phenyl]propanoic acid Chemical compound CC1=CC(C)=CC(C2(CCOCC2)NC(=O)C=2C(=CC=C(COC=3C(=CC=CC=3)Cl)C=2)CCC(O)=O)=C1 IWNDCXNXKFSZHP-UHFFFAOYSA-N 0.000 claims 1
- MFYXLZCTDSRYEI-UHFFFAOYSA-N 3-[4-[(2-chlorophenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=CC=C1Cl MFYXLZCTDSRYEI-UHFFFAOYSA-N 0.000 claims 1
- ZQJASUOLZOJNPQ-UHFFFAOYSA-N 3-[4-[(2-cyanophenoxy)methyl]-2-(naphthalen-1-ylmethylcarbamoyl)phenyl]propanoic acid Chemical compound C1=C(C(=O)NCC=2C3=CC=CC=C3C=CC=2)C(CCC(=O)O)=CC=C1COC1=CC=CC=C1C#N ZQJASUOLZOJNPQ-UHFFFAOYSA-N 0.000 claims 1
- LMHJZQZWNNKCMM-UHFFFAOYSA-N 3-[4-[(2-cyanophenoxy)methyl]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1C#N LMHJZQZWNNKCMM-UHFFFAOYSA-N 0.000 claims 1
- UIIQFDMVZOSTSN-UHFFFAOYSA-N 3-[4-[(2-cyanophenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=CC=C1C#N UIIQFDMVZOSTSN-UHFFFAOYSA-N 0.000 claims 1
- PYYGOOSWMXHMAP-UHFFFAOYSA-N 3-[4-[(2-cyanopyridin-3-yl)oxymethyl]-2-(2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound C1=C(OCCC=2C=C3C=CC=CC3=CC=2)C(CCC(=O)O)=CC=C1COC1=CC=CN=C1C#N PYYGOOSWMXHMAP-UHFFFAOYSA-N 0.000 claims 1
- FXHPGTFGRBOJCN-UHFFFAOYSA-N 3-[4-[(2-formylphenoxy)methyl]-2-(naphthalen-1-ylmethylcarbamoyl)phenyl]propanoic acid Chemical compound C1=C(C(=O)NCC=2C3=CC=CC=C3C=CC=2)C(CCC(=O)O)=CC=C1COC1=CC=CC=C1C=O FXHPGTFGRBOJCN-UHFFFAOYSA-N 0.000 claims 1
- WCTXRJJPXWIFOG-UHFFFAOYSA-N 3-[4-[(2-hydroxyphenoxy)methyl]-2-[(3-methyl-1-phenylbutyl)carbamoyl]phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1O WCTXRJJPXWIFOG-UHFFFAOYSA-N 0.000 claims 1
- AQSCYVVWPBUYQP-UHFFFAOYSA-N 3-[4-[(2-methoxyphenoxy)methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound COC1=CC=CC=C1OCC1=CC=C(CCC(O)=O)C(OCCC=2C=C3C=CC=CC3=CC=2)=C1 AQSCYVVWPBUYQP-UHFFFAOYSA-N 0.000 claims 1
- UFIRYFZWVRNVTK-UHFFFAOYSA-N 3-[4-[(2-methoxyphenoxy)methyl]-2-(naphthalen-1-ylmethylcarbamoyl)phenyl]propanoic acid Chemical compound COC1=CC=CC=C1OCC1=CC=C(CCC(O)=O)C(C(=O)NCC=2C3=CC=CC=C3C=CC=2)=C1 UFIRYFZWVRNVTK-UHFFFAOYSA-N 0.000 claims 1
- KFGWZSIZWOFDNE-UHFFFAOYSA-N 3-[4-[(2-methylanilino)methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound CC1=CC=CC=C1NCC1=CC=C(CCC(O)=O)C(OCCC=2C=C3C=CC=CC3=CC=2)=C1 KFGWZSIZWOFDNE-UHFFFAOYSA-N 0.000 claims 1
- XOZGOBKUISPAJD-UHFFFAOYSA-N 3-[4-[(2-methylphenoxy)methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound CC1=CC=CC=C1OCC1=CC=C(CCC(O)=O)C(OCCC=2C=C3C=CC=CC3=CC=2)=C1 XOZGOBKUISPAJD-UHFFFAOYSA-N 0.000 claims 1
- PXBSWLWSABSOPH-UHFFFAOYSA-N 3-[4-[(2-methylphenoxy)methyl]-2-(naphthalen-1-ylmethylcarbamoyl)phenyl]propanoic acid Chemical compound CC1=CC=CC=C1OCC1=CC=C(CCC(O)=O)C(C(=O)NCC=2C3=CC=CC=C3C=CC=2)=C1 PXBSWLWSABSOPH-UHFFFAOYSA-N 0.000 claims 1
- PSDMAEMSFCEEJX-UHFFFAOYSA-N 3-[4-[(2-methylphenoxy)methyl]-2-[(3-methyl-1-phenylbutyl)carbamoyl]phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC=C1C PSDMAEMSFCEEJX-UHFFFAOYSA-N 0.000 claims 1
- FCWGFRDXAPLQNA-UHFFFAOYSA-N 3-[4-[(2-methylphenyl)sulfanylmethyl]-2-(naphthalen-1-ylmethylcarbamoyl)phenyl]propanoic acid Chemical compound C1(=CC=CC2=CC=CC=C12)CNC(=O)C1=C(C=CC(=C1)CSC1=C(C=CC=C1)C)CCC(=O)O FCWGFRDXAPLQNA-UHFFFAOYSA-N 0.000 claims 1
- CTDJSSCVTADPAU-UHFFFAOYSA-N 3-[4-[(2-methylpyridin-3-yl)oxymethyl]-2-(2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound CC1=NC=CC=C1OCC1=CC=C(CCC(O)=O)C(OCCC=2C=C3C=CC=CC3=CC=2)=C1 CTDJSSCVTADPAU-UHFFFAOYSA-N 0.000 claims 1
- ZZVOTZYARHKZJB-UHFFFAOYSA-N 3-[4-[(2-methylsulfonylphenoxy)methyl]-2-(naphthalen-1-ylmethylcarbamoyl)phenyl]propanoic acid Chemical compound CS(=O)(=O)C1=CC=CC=C1OCC1=CC=C(CCC(O)=O)C(C(=O)NCC=2C3=CC=CC=C3C=CC=2)=C1 ZZVOTZYARHKZJB-UHFFFAOYSA-N 0.000 claims 1
- XDKCNPZMFPXSIB-UHFFFAOYSA-N 3-[4-[(3,4-diethoxyphenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C1=C(OCC)C(OCC)=CC=C1COC1=CC=C(CCC(O)=O)C(C(=O)NC(CC(C)C)C=2C=C(C)C=C(C)C=2)=C1 XDKCNPZMFPXSIB-UHFFFAOYSA-N 0.000 claims 1
- AETRTPVWFFIQJU-UHFFFAOYSA-N 3-[4-[(3,4-difluorophenoxy)methyl]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=C(F)C(F)=C1 AETRTPVWFFIQJU-UHFFFAOYSA-N 0.000 claims 1
- GHIFWKQKCRRSBQ-UHFFFAOYSA-N 3-[4-[(3,4-difluorophenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=C(F)C(F)=C1 GHIFWKQKCRRSBQ-UHFFFAOYSA-N 0.000 claims 1
- XYQLTODFSKVEQR-UHFFFAOYSA-N 3-[4-[(3,4-dimethylphenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=C(C)C(C)=C1 XYQLTODFSKVEQR-UHFFFAOYSA-N 0.000 claims 1
- XQYOJCNMIBBAEQ-UHFFFAOYSA-N 3-[4-[(3,5-difluorophenoxy)methyl]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC(F)=CC(F)=C1 XQYOJCNMIBBAEQ-UHFFFAOYSA-N 0.000 claims 1
- RESNPKDHEXBDAO-UHFFFAOYSA-N 3-[4-[(3,5-difluorophenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC(F)=CC(F)=C1 RESNPKDHEXBDAO-UHFFFAOYSA-N 0.000 claims 1
- JPIZVBIBRKDZAX-UHFFFAOYSA-N 3-[4-[(3,5-dimethylphenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC(C)=CC(C)=C1 JPIZVBIBRKDZAX-UHFFFAOYSA-N 0.000 claims 1
- XQOMWOUDAJQLFB-UHFFFAOYSA-N 3-[4-[(3,5-dimethylpyrazol-1-yl)methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound N1=C(C)C=C(C)N1CC1=CC=C(CCC(O)=O)C(OCCC=2C=C3C=CC=CC3=CC=2)=C1 XQOMWOUDAJQLFB-UHFFFAOYSA-N 0.000 claims 1
- MKHSCJZETIFCLK-UHFFFAOYSA-N 3-[4-[(3,5-ditert-butyl-2-methoxyphenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C1=C(C(C)(C)C)C=C(C(C)(C)C)C(OC)=C1COC1=CC=C(CCC(O)=O)C(C(=O)NC(CC(C)C)C=2C=C(C)C=C(C)C=2)=C1 MKHSCJZETIFCLK-UHFFFAOYSA-N 0.000 claims 1
- ANOIVXXKYNECAL-UHFFFAOYSA-N 3-[4-[(3-carbamoylphenoxy)methyl]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC(C(N)=O)=C1 ANOIVXXKYNECAL-UHFFFAOYSA-N 0.000 claims 1
- NYMKOBBYFBHYQY-UHFFFAOYSA-N 3-[4-[(3-chloro-2,6-difluorophenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=C(F)C=CC(Cl)=C1F NYMKOBBYFBHYQY-UHFFFAOYSA-N 0.000 claims 1
- ZXBFQPQBTDEODA-UHFFFAOYSA-N 3-[4-[(3-chloro-2-fluorophenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=CC(Cl)=C1F ZXBFQPQBTDEODA-UHFFFAOYSA-N 0.000 claims 1
- SYDMMKZBSKPAEX-UHFFFAOYSA-N 3-[4-[(3-chloro-2-methylphenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=CC(Cl)=C1C SYDMMKZBSKPAEX-UHFFFAOYSA-N 0.000 claims 1
- VRBAIJLJFPPYHD-UHFFFAOYSA-N 3-[4-[(3-chloro-4-fluorophenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=C(F)C(Cl)=C1 VRBAIJLJFPPYHD-UHFFFAOYSA-N 0.000 claims 1
- VSONIJBYVAGXHF-MUUNZHRXSA-N 3-[4-[(3-chlorophenoxy)methyl]-2-[[(1r)-1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound N([C@H](CC(C)C)C=1C=C(C)C=C(C)C=1)C(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC(Cl)=C1 VSONIJBYVAGXHF-MUUNZHRXSA-N 0.000 claims 1
- VSONIJBYVAGXHF-UHFFFAOYSA-N 3-[4-[(3-chlorophenoxy)methyl]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC(Cl)=C1 VSONIJBYVAGXHF-UHFFFAOYSA-N 0.000 claims 1
- PGDWRXBLXPPJRU-UHFFFAOYSA-N 3-[4-[(3-chlorophenoxy)methyl]-2-[[4-(3,5-dimethylphenyl)oxan-4-yl]carbamoyl]phenyl]propanoic acid Chemical compound CC1=CC(C)=CC(C2(CCOCC2)NC(=O)C=2C(=CC=C(COC=3C=C(Cl)C=CC=3)C=2)CCC(O)=O)=C1 PGDWRXBLXPPJRU-UHFFFAOYSA-N 0.000 claims 1
- MTTRZXVGMSHHKZ-UHFFFAOYSA-N 3-[4-[(3-chlorophenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=CC(Cl)=C1 MTTRZXVGMSHHKZ-UHFFFAOYSA-N 0.000 claims 1
- YEIMNQNPRGIPFD-UHFFFAOYSA-N 3-[4-[(3-cyano-5-methoxyphenoxy)methyl]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound N#CC1=CC(OC)=CC(OCC=2C=C(C(CCC(O)=O)=CC=2)C(=O)NC(CC(C)C)C=2C=C(C)C=C(C)C=2)=C1 YEIMNQNPRGIPFD-UHFFFAOYSA-N 0.000 claims 1
- FTSZPLAXIXQAND-UHFFFAOYSA-N 3-[4-[(3-cyanoanilino)methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound C1=C(OCCC=2C=C3C=CC=CC3=CC=2)C(CCC(=O)O)=CC=C1CNC1=CC=CC(C#N)=C1 FTSZPLAXIXQAND-UHFFFAOYSA-N 0.000 claims 1
- RGGIWLFQJAXHQH-UHFFFAOYSA-N 3-[4-[(3-cyanophenoxy)methyl]-2-(2-hydroxy-2-naphthalen-2-ylethoxy)phenyl]-n-(3,4-difluorophenyl)sulfonylpropanamide Chemical compound C=1C=C2C=CC=CC2=CC=1C(O)COC(C(=CC=1)CCC(=O)NS(=O)(=O)C=2C=C(F)C(F)=CC=2)=CC=1COC1=CC=CC(C#N)=C1 RGGIWLFQJAXHQH-UHFFFAOYSA-N 0.000 claims 1
- IKMWSMHRJCHVJC-UHFFFAOYSA-N 3-[4-[(3-cyanophenoxy)methyl]-2-(2-hydroxy-2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound C=1C=C2C=CC=CC2=CC=1C(O)COC(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC(C#N)=C1 IKMWSMHRJCHVJC-UHFFFAOYSA-N 0.000 claims 1
- QSSPZGSVTXRALP-UHFFFAOYSA-N 3-[4-[(3-cyanophenoxy)methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]-n-(3,4-dichlorophenyl)sulfonylpropanamide Chemical compound C1=C(Cl)C(Cl)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1COC1=CC=CC(C#N)=C1 QSSPZGSVTXRALP-UHFFFAOYSA-N 0.000 claims 1
- WLWLJPIELFZZBY-UHFFFAOYSA-N 3-[4-[(3-cyanophenoxy)methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]-n-(3,4-difluorophenyl)sulfonylpropanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1COC1=CC=CC(C#N)=C1 WLWLJPIELFZZBY-UHFFFAOYSA-N 0.000 claims 1
- JNSKNPSETNMHDD-UHFFFAOYSA-N 3-[4-[(3-cyanophenoxy)methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]-n-(3-cyanophenyl)sulfonylpropanamide Chemical compound C=1C=CC(C#N)=CC=1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1COC1=CC=CC(C#N)=C1 JNSKNPSETNMHDD-UHFFFAOYSA-N 0.000 claims 1
- HLERTKDNHCIDKC-UHFFFAOYSA-N 3-[4-[(3-cyanophenoxy)methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound C1=C(OCCC=2C=C3C=CC=CC3=CC=2)C(CCC(=O)O)=CC=C1COC1=CC=CC(C#N)=C1 HLERTKDNHCIDKC-UHFFFAOYSA-N 0.000 claims 1
- BSJFVFJXOWKDLC-UHFFFAOYSA-N 3-[4-[(3-cyanophenoxy)methyl]-2-(2-phenylethoxy)phenyl]-n-(3,4-difluorophenyl)sulfonylpropanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2C=CC=CC=2)=CC=C1COC1=CC=CC(C#N)=C1 BSJFVFJXOWKDLC-UHFFFAOYSA-N 0.000 claims 1
- YERPPDDYTBHOTI-UHFFFAOYSA-N 3-[4-[(3-cyanophenoxy)methyl]-2-(2-phenylethoxy)phenyl]propanoic acid Chemical compound C1=C(OCCC=2C=CC=CC=2)C(CCC(=O)O)=CC=C1COC1=CC=CC(C#N)=C1 YERPPDDYTBHOTI-UHFFFAOYSA-N 0.000 claims 1
- MRTUALWZCOHYAP-UHFFFAOYSA-N 3-[4-[(3-cyanophenoxy)methyl]-2-(naphthalen-1-ylmethylcarbamoyl)phenyl]propanoic acid Chemical compound C1=C(C(=O)NCC=2C3=CC=CC=C3C=CC=2)C(CCC(=O)O)=CC=C1COC1=CC=CC(C#N)=C1 MRTUALWZCOHYAP-UHFFFAOYSA-N 0.000 claims 1
- DNLGAZKMGLAEMG-UHFFFAOYSA-N 3-[4-[(3-cyanophenoxy)methyl]-2-[(3-methyl-1-naphthalen-1-ylbutyl)carbamoyl]phenyl]propanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC(C#N)=C1 DNLGAZKMGLAEMG-UHFFFAOYSA-N 0.000 claims 1
- YCQSKUBDAOBOMC-UHFFFAOYSA-N 3-[4-[(3-cyanophenoxy)methyl]-2-[1-(3,5-dimethylphenyl)butylcarbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CCC)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC(C#N)=C1 YCQSKUBDAOBOMC-UHFFFAOYSA-N 0.000 claims 1
- HWEICVLLATUATA-UHFFFAOYSA-N 3-[4-[(3-cyanophenoxy)methyl]-2-[1-(3,5-dimethylphenyl)propylcarbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC(C#N)=C1 HWEICVLLATUATA-UHFFFAOYSA-N 0.000 claims 1
- LOJQEPYOFFMVAJ-UHFFFAOYSA-N 3-[4-[(3-cyanophenoxy)methyl]-2-[2-(4-fluoro-3-methylphenyl)-4-methylpentoxy]phenyl]propanoic acid Chemical compound C=1C=C(F)C(C)=CC=1C(CC(C)C)COC(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC(C#N)=C1 LOJQEPYOFFMVAJ-UHFFFAOYSA-N 0.000 claims 1
- RTNUVYOOKJGYIN-GDLZYMKVSA-N 3-[4-[(3-cyanophenoxy)methyl]-2-[[(1r)-1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound N([C@H](CC(C)C)C=1C=C(C)C=C(C)C=1)C(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC(C#N)=C1 RTNUVYOOKJGYIN-GDLZYMKVSA-N 0.000 claims 1
- HKMMZKDOAJRAAE-UHFFFAOYSA-N 3-[4-[(3-cyanophenoxy)methyl]-2-[[1-(3,4-dimethoxyphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C1=C(OC)C(OC)=CC=C1C(CC(C)C)NC(=O)C1=CC(COC=2C=C(C=CC=2)C#N)=CC=C1CCC(O)=O HKMMZKDOAJRAAE-UHFFFAOYSA-N 0.000 claims 1
- YHFGSQZOEVZWFA-UHFFFAOYSA-N 3-[4-[(3-cyanophenoxy)methyl]-2-[[1-(3,5-difluorophenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(F)=CC(F)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC(C#N)=C1 YHFGSQZOEVZWFA-UHFFFAOYSA-N 0.000 claims 1
- NUUHFUGXPRSJOH-UHFFFAOYSA-N 3-[4-[(3-cyanophenoxy)methyl]-2-[[1-(3,5-dimethoxyphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound COC1=CC(OC)=CC(C(CC(C)C)NC(=O)C=2C(=CC=C(COC=3C=C(C=CC=3)C#N)C=2)CCC(O)=O)=C1 NUUHFUGXPRSJOH-UHFFFAOYSA-N 0.000 claims 1
- RTNUVYOOKJGYIN-UHFFFAOYSA-N 3-[4-[(3-cyanophenoxy)methyl]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC(C#N)=C1 RTNUVYOOKJGYIN-UHFFFAOYSA-N 0.000 claims 1
- GDWMTIHMWHKREU-UHFFFAOYSA-N 3-[4-[(3-cyanophenoxy)methyl]-2-[[1-(3-methoxyphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound COC1=CC=CC(C(CC(C)C)NC(=O)C=2C(=CC=C(COC=3C=C(C=CC=3)C#N)C=2)CCC(O)=O)=C1 GDWMTIHMWHKREU-UHFFFAOYSA-N 0.000 claims 1
- AQFQEYKSALVFDX-UHFFFAOYSA-N 3-[4-[(3-cyanophenoxy)methyl]-2-[[1-(4-fluoro-3-methylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C=C(F)C(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC(C#N)=C1 AQFQEYKSALVFDX-UHFFFAOYSA-N 0.000 claims 1
- QJALELWCHCKRGI-UHFFFAOYSA-N 3-[4-[(3-cyanophenoxy)methyl]-2-[[1-(4-fluorophenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C=C(F)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC(C#N)=C1 QJALELWCHCKRGI-UHFFFAOYSA-N 0.000 claims 1
- PZUIPRHJTPPKCO-UHFFFAOYSA-N 3-[4-[(3-cyanophenoxy)methyl]-2-[[3-methyl-1-(3-methylphenyl)butyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC(C#N)=C1 PZUIPRHJTPPKCO-UHFFFAOYSA-N 0.000 claims 1
- XAAZXWPSDAHOQI-UHFFFAOYSA-N 3-[4-[(3-cyanophenoxy)methyl]-2-[[4-(3,5-dimethylphenyl)oxan-4-yl]carbamoyl]phenyl]propanoic acid Chemical compound CC1=CC(C)=CC(C2(CCOCC2)NC(=O)C=2C(=CC=C(COC=3C=C(C=CC=3)C#N)C=2)CCC(O)=O)=C1 XAAZXWPSDAHOQI-UHFFFAOYSA-N 0.000 claims 1
- GLNPKEPBUWIYIY-UHFFFAOYSA-N 3-[4-[(3-cyanophenyl)methoxy]-2-[(3-methyl-1-phenylbutyl)carbamoyl]phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=CC(C#N)=C1 GLNPKEPBUWIYIY-UHFFFAOYSA-N 0.000 claims 1
- LVGBHHNNHKSRKS-UHFFFAOYSA-N 3-[4-[(3-cyanophenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=CC(C#N)=C1 LVGBHHNNHKSRKS-UHFFFAOYSA-N 0.000 claims 1
- WMWFMPNTAGVKRS-UHFFFAOYSA-N 3-[4-[(3-methyl-2-oxoimidazolidin-1-yl)methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound O=C1N(C)CCN1CC1=CC=C(CCC(O)=O)C(OCCC=2C=C3C=CC=CC3=CC=2)=C1 WMWFMPNTAGVKRS-UHFFFAOYSA-N 0.000 claims 1
- FYGFBZPHRFRBRN-UHFFFAOYSA-N 3-[4-[(4-acetylpiperazin-1-yl)methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]-n-(3,4-difluorophenyl)sulfonylpropanamide Chemical compound C1CN(C(=O)C)CCN1CC(C=C1OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CCC(=O)NS(=O)(=O)C1=CC=C(F)C(F)=C1 FYGFBZPHRFRBRN-UHFFFAOYSA-N 0.000 claims 1
- CWFPVCKEWRTVKD-UHFFFAOYSA-N 3-[4-[(4-acetylpiperazin-1-yl)methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound C1CN(C(=O)C)CCN1CC1=CC=C(CCC(O)=O)C(OCCC=2C=C3C=CC=CC3=CC=2)=C1 CWFPVCKEWRTVKD-UHFFFAOYSA-N 0.000 claims 1
- YFCPEAHJQFZKBJ-UHFFFAOYSA-N 3-[4-[(4-butylphenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C1=CC(CCCC)=CC=C1COC1=CC=C(CCC(O)=O)C(C(=O)NC(CC(C)C)C=2C=C(C)C=C(C)C=2)=C1 YFCPEAHJQFZKBJ-UHFFFAOYSA-N 0.000 claims 1
- ZANITTLMEJTUOG-UHFFFAOYSA-N 3-[4-[(4-chloro-2,6-difluorophenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=C(F)C=C(Cl)C=C1F ZANITTLMEJTUOG-UHFFFAOYSA-N 0.000 claims 1
- QHVNYIADTMHQME-UHFFFAOYSA-N 3-[4-[(4-chloro-2-methoxyphenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound COC1=CC(Cl)=CC=C1COC1=CC=C(CCC(O)=O)C(C(=O)NC(CC(C)C)C=2C=C(C)C=C(C)C=2)=C1 QHVNYIADTMHQME-UHFFFAOYSA-N 0.000 claims 1
- IQMGHXKDJBUCOL-UHFFFAOYSA-N 3-[4-[(4-chloro-3-fluorophenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=C(Cl)C(F)=C1 IQMGHXKDJBUCOL-UHFFFAOYSA-N 0.000 claims 1
- GDNZFYOGEPYRIK-UHFFFAOYSA-N 3-[4-[(4-chlorophenoxy)methyl]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=C(Cl)C=C1 GDNZFYOGEPYRIK-UHFFFAOYSA-N 0.000 claims 1
- CPZXKMLSUGDHDJ-UHFFFAOYSA-N 3-[4-[(4-chlorophenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=C(Cl)C=C1 CPZXKMLSUGDHDJ-UHFFFAOYSA-N 0.000 claims 1
- WUMJSOHUBQXRNX-UHFFFAOYSA-N 3-[4-[(4-cyano-3-fluorophenoxy)methyl]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=C(C#N)C(F)=C1 WUMJSOHUBQXRNX-UHFFFAOYSA-N 0.000 claims 1
- XWKSWMRPJUAMIZ-UHFFFAOYSA-N 3-[4-[(4-cyanophenoxy)methyl]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=C(C#N)C=C1 XWKSWMRPJUAMIZ-UHFFFAOYSA-N 0.000 claims 1
- QNLPDXCXYHOZLX-UHFFFAOYSA-N 3-[4-[(4-fluorophenoxy)methyl]-2-[(3-methyl-1-naphthalen-1-ylbutyl)carbamoyl]phenyl]propanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=C(F)C=C1 QNLPDXCXYHOZLX-UHFFFAOYSA-N 0.000 claims 1
- YDSHBGQXEOTEJJ-UHFFFAOYSA-N 3-[4-[(4-methylimidazol-1-yl)methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound C1=NC(C)=CN1CC1=CC=C(CCC(O)=O)C(OCCC=2C=C3C=CC=CC3=CC=2)=C1 YDSHBGQXEOTEJJ-UHFFFAOYSA-N 0.000 claims 1
- NAGGDWUBGLHCFK-UHFFFAOYSA-N 3-[4-[(4-methylpiperazin-1-yl)methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound C1CN(C)CCN1CC1=CC=C(CCC(O)=O)C(OCCC=2C=C3C=CC=CC3=CC=2)=C1 NAGGDWUBGLHCFK-UHFFFAOYSA-N 0.000 claims 1
- LGCHSYKQHXHMGL-UHFFFAOYSA-N 3-[4-[(4-methylpyrazol-1-yl)methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound C1=C(C)C=NN1CC1=CC=C(CCC(O)=O)C(OCCC=2C=C3C=CC=CC3=CC=2)=C1 LGCHSYKQHXHMGL-UHFFFAOYSA-N 0.000 claims 1
- PYZVUTZHAZDOFN-UHFFFAOYSA-N 3-[4-[(4-tert-butylphenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=C(C(C)(C)C)C=C1 PYZVUTZHAZDOFN-UHFFFAOYSA-N 0.000 claims 1
- QNBRUOLXJVHQPW-UHFFFAOYSA-N 3-[4-[(5-chloro-2-methoxyphenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound COC1=CC=C(Cl)C=C1COC1=CC=C(CCC(O)=O)C(C(=O)NC(CC(C)C)C=2C=C(C)C=C(C)C=2)=C1 QNBRUOLXJVHQPW-UHFFFAOYSA-N 0.000 claims 1
- MUKZOHTZFRIMDI-UHFFFAOYSA-N 3-[4-[(6-chloro-2-fluoro-3-methylphenyl)methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=C(Cl)C=CC(C)=C1F MUKZOHTZFRIMDI-UHFFFAOYSA-N 0.000 claims 1
- RQPFZDPWVWOVLR-UHFFFAOYSA-N 3-[4-[(6-methylpyridin-3-yl)oxymethyl]-2-(2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound C1=NC(C)=CC=C1OCC1=CC=C(CCC(O)=O)C(OCCC=2C=C3C=CC=CC3=CC=2)=C1 RQPFZDPWVWOVLR-UHFFFAOYSA-N 0.000 claims 1
- VIBBOXFPUHCOEK-UHFFFAOYSA-N 3-[4-[(furan-2-carbonylamino)methyl]-2-[(3-methyl-1-phenylbutyl)carbamoyl]phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1CNC(=O)C1=CC=CO1 VIBBOXFPUHCOEK-UHFFFAOYSA-N 0.000 claims 1
- XULCURZHAFKYAS-UHFFFAOYSA-N 3-[4-[(n-ethylanilino)methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound C=1C=C(CCC(O)=O)C(OCCC=2C=C3C=CC=CC3=CC=2)=CC=1CN(CC)C1=CC=CC=C1 XULCURZHAFKYAS-UHFFFAOYSA-N 0.000 claims 1
- JLSWGKBGQRCMFK-UHFFFAOYSA-N 3-[4-[(n-methylanilino)methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound C=1C=C(CCC(O)=O)C(OCCC=2C=C3C=CC=CC3=CC=2)=CC=1CN(C)C1=CC=CC=C1 JLSWGKBGQRCMFK-UHFFFAOYSA-N 0.000 claims 1
- RENFVKBGOQMNEB-UHFFFAOYSA-N 3-[4-[[2,5-bis(trifluoromethyl)phenyl]methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC(C(F)(F)F)=CC=C1C(F)(F)F RENFVKBGOQMNEB-UHFFFAOYSA-N 0.000 claims 1
- XKBZTOWWAWECEG-UHFFFAOYSA-N 3-[4-[[2-(4-chlorophenyl)sulfanylphenyl]methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=CC=C1SC1=CC=C(Cl)C=C1 XKBZTOWWAWECEG-UHFFFAOYSA-N 0.000 claims 1
- RKHIUDRHSXTXGA-UHFFFAOYSA-N 3-[4-[[2-(hydroxymethyl)phenoxy]methyl]-2-(naphthalen-1-ylmethylcarbamoyl)phenyl]propanoic acid Chemical compound OCC1=CC=CC=C1OCC1=CC=C(CCC(O)=O)C(C(=O)NCC=2C3=CC=CC=C3C=CC=2)=C1 RKHIUDRHSXTXGA-UHFFFAOYSA-N 0.000 claims 1
- NXYMUBGPFAELPL-UHFFFAOYSA-N 3-[4-[[2-(methoxymethyl)phenoxy]methyl]-2-(naphthalen-1-ylmethylcarbamoyl)phenyl]propanoic acid Chemical compound COCC1=CC=CC=C1OCC1=CC=C(CCC(O)=O)C(C(=O)NCC=2C3=CC=CC=C3C=CC=2)=C1 NXYMUBGPFAELPL-UHFFFAOYSA-N 0.000 claims 1
- FAZGVMKOPXGVIO-UHFFFAOYSA-N 3-[4-[[2-chloro-5-(trifluoromethyl)phenyl]methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC(C(F)(F)F)=CC=C1Cl FAZGVMKOPXGVIO-UHFFFAOYSA-N 0.000 claims 1
- VENZLUIWWSYIFL-UHFFFAOYSA-N 3-[4-[[3-(4-tert-butylphenoxy)phenyl]methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC(C=1)=CC=CC=1OC1=CC=C(C(C)(C)C)C=C1 VENZLUIWWSYIFL-UHFFFAOYSA-N 0.000 claims 1
- NPZVKPVQVDPRHA-UHFFFAOYSA-N 3-[4-[[3-(dimethylamino)phenyl]methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=CC(N(C)C)=C1 NPZVKPVQVDPRHA-UHFFFAOYSA-N 0.000 claims 1
- YFEUTVRDINLQNB-UHFFFAOYSA-N 3-[4-[[3-(dimethylcarbamoyl)phenoxy]methyl]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=CC(C(=O)N(C)C)=C1 YFEUTVRDINLQNB-UHFFFAOYSA-N 0.000 claims 1
- KLSRGZJEWRNOCF-UHFFFAOYSA-N 3-[4-[[3-chloro-2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC(C(F)(F)F)=CC(Cl)=C1F KLSRGZJEWRNOCF-UHFFFAOYSA-N 0.000 claims 1
- PXVLOVDERUDPIF-UHFFFAOYSA-N 3-[4-[[4-(2-amino-2-oxoethyl)phenoxy]methyl]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1COC1=CC=C(CC(N)=O)C=C1 PXVLOVDERUDPIF-UHFFFAOYSA-N 0.000 claims 1
- NCXUPSXOAYQZID-UHFFFAOYSA-N 3-[4-[[4-(difluoromethoxy)phenyl]methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=C(OC(F)F)C=C1 NCXUPSXOAYQZID-UHFFFAOYSA-N 0.000 claims 1
- JBVDDOMZNDOIKJ-UHFFFAOYSA-N 3-[4-[[4-chloro-3-(trifluoromethyl)phenyl]methoxy]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1OCC1=CC=C(Cl)C(C(F)(F)F)=C1 JBVDDOMZNDOIKJ-UHFFFAOYSA-N 0.000 claims 1
- PMXGIRJFTUBPQQ-UHFFFAOYSA-N 3-[4-[[acetyl(methyl)amino]methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound CC(=O)N(C)CC1=CC=C(CCC(O)=O)C(OCCC=2C=C3C=CC=CC3=CC=2)=C1 PMXGIRJFTUBPQQ-UHFFFAOYSA-N 0.000 claims 1
- UGKKNKJQKKKELJ-UHFFFAOYSA-N 3-[4-[[ethoxycarbonyl(methyl)amino]methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound CCOC(=O)N(C)CC1=CC=C(CCC(O)=O)C(OCCC=2C=C3C=CC=CC3=CC=2)=C1 UGKKNKJQKKKELJ-UHFFFAOYSA-N 0.000 claims 1
- QMDTZBZVYWLQKG-UHFFFAOYSA-N 3-[4-[acetyl(benzyl)amino]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1N(C(C)=O)CC1=CC=CC=C1 QMDTZBZVYWLQKG-UHFFFAOYSA-N 0.000 claims 1
- LVSUILGFBYKODX-UHFFFAOYSA-N 3-[4-[benzoyl(methyl)amino]-2-(2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound C=1C=C(CCC(O)=O)C(OCCC=2C=C3C=CC=CC3=CC=2)=CC=1N(C)C(=O)C1=CC=CC=C1 LVSUILGFBYKODX-UHFFFAOYSA-N 0.000 claims 1
- AEIQZIOXGLMHLI-UHFFFAOYSA-N 3-[4-[benzyl(methyl)amino]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1N(C)CC1=CC=CC=C1 AEIQZIOXGLMHLI-UHFFFAOYSA-N 0.000 claims 1
- BKMXZFMHRVHFLK-UHFFFAOYSA-N 3-[4-[benzyl(methylsulfonyl)amino]-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1N(S(C)(=O)=O)CC1=CC=CC=C1 BKMXZFMHRVHFLK-UHFFFAOYSA-N 0.000 claims 1
- UDHXQFQRZBMHBA-UHFFFAOYSA-N 3-[4-[methyl(methylsulfonyl)amino]-2-(2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound CS(=O)(=O)N(C)C1=CC=C(CCC(O)=O)C(OCCC=2C=C3C=CC=CC3=CC=2)=C1 UDHXQFQRZBMHBA-UHFFFAOYSA-N 0.000 claims 1
- KEQVVWRWVRRHTL-UHFFFAOYSA-N 3-[4-[methyl(methylsulfonyl)amino]-2-[(3-methyl-1-phenylbutyl)carbamoyl]phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C1=CC(N(C)S(C)(=O)=O)=CC=C1CCC(O)=O KEQVVWRWVRRHTL-UHFFFAOYSA-N 0.000 claims 1
- WWVYXMYWPOGNNB-UHFFFAOYSA-N 3-[4-acetamido-2-(2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound CC(=O)NC1=CC=C(CCC(O)=O)C(OCCC=2C=C3C=CC=CC3=CC=2)=C1 WWVYXMYWPOGNNB-UHFFFAOYSA-N 0.000 claims 1
- CRFXFCYSUAIBIV-UHFFFAOYSA-N 3-[4-benzamido-2-(2-naphthalen-2-ylethoxy)phenyl]propanoic acid Chemical compound C1=C(OCCC=2C=C3C=CC=CC3=CC=2)C(CCC(=O)O)=CC=C1NC(=O)C1=CC=CC=C1 CRFXFCYSUAIBIV-UHFFFAOYSA-N 0.000 claims 1
- GAFSDLLIAKSFHC-UHFFFAOYSA-N 3-[4-benzamido-2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(O)=O)=CC=1NC(=O)C1=CC=CC=C1 GAFSDLLIAKSFHC-UHFFFAOYSA-N 0.000 claims 1
- LXJXJKKRSJSMFP-UHFFFAOYSA-N 3-[4-cyano-2-[(3-methyl-1-phenylbutyl)carbamoyl]phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C1=CC(C#N)=CC=C1CCC(O)=O LXJXJKKRSJSMFP-UHFFFAOYSA-N 0.000 claims 1
- MDNSUTSBLNKAQD-UHFFFAOYSA-N 3-[4-phenoxy-2-(4-phenylbutan-2-ylcarbamoyl)phenyl]propanoic acid Chemical compound C=1C(OC=2C=CC=CC=2)=CC=C(CCC(O)=O)C=1C(=O)NC(C)CCC1=CC=CC=C1 MDNSUTSBLNKAQD-UHFFFAOYSA-N 0.000 claims 1
- YQANSFVIEDMPLO-OAQYLSRUSA-N 3-[4-phenoxy-2-[[(1r)-1-(4-phenylphenyl)ethyl]carbamoyl]phenyl]propanoic acid Chemical compound N([C@H](C)C=1C=CC(=CC=1)C=1C=CC=CC=1)C(=O)C(C(=CC=1)CCC(O)=O)=CC=1OC1=CC=CC=C1 YQANSFVIEDMPLO-OAQYLSRUSA-N 0.000 claims 1
- MGZGGVILDSZUTI-QGZVFWFLSA-N 3-[4-phenoxy-2-[[(1r)-1-phenylethyl]carbamoyl]phenyl]propanoic acid Chemical compound N([C@H](C)C=1C=CC=CC=1)C(=O)C(C(=CC=1)CCC(O)=O)=CC=1OC1=CC=CC=C1 MGZGGVILDSZUTI-QGZVFWFLSA-N 0.000 claims 1
- VHKRELMXRYVLIU-UHFFFAOYSA-N 3-[5-chloro-2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound C1=C(OCCC=2C=C3C=CC=CC3=CC=2)C(CCC(=O)O)=CC(Cl)=C1CN1C=CC=N1 VHKRELMXRYVLIU-UHFFFAOYSA-N 0.000 claims 1
- SSARZRFUKOWBQW-UHFFFAOYSA-N 3-[5-methoxy-2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanoic acid Chemical compound COC1=CC(CCC(O)=O)=C(OCCC=2C=C3C=CC=CC3=CC=2)C=C1CN1C=CC=N1 SSARZRFUKOWBQW-UHFFFAOYSA-N 0.000 claims 1
- JNWRXWISXCTDEB-UHFFFAOYSA-N 3-[5-methoxy-2-[(3-methyl-1-phenylbutyl)carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound COC1=CC(CCC(O)=O)=C(C(=O)NC(CC(C)C)C=2C=CC=CC=2)C=C1COC1=CC=CC=C1 JNWRXWISXCTDEB-UHFFFAOYSA-N 0.000 claims 1
- XPBROOJDGXYLLI-UHFFFAOYSA-N 3-[5-methyl-2-[(3-methyl-1-phenylbutyl)carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C(C(=CC=1C)CCC(O)=O)=CC=1COC1=CC=CC=C1 XPBROOJDGXYLLI-UHFFFAOYSA-N 0.000 claims 1
- QIOUMQLKBWFVGE-UHFFFAOYSA-N 3-[6-cyano-1-(2-naphthalen-1-ylpropanoyl)indol-3-yl]-n-(3,4-difluorophenyl)sulfonylpropanamide Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)N(C1=CC(=CC=C11)C#N)C=C1CCC(=O)NS(=O)(=O)C1=CC=C(F)C(F)=C1 QIOUMQLKBWFVGE-UHFFFAOYSA-N 0.000 claims 1
- GLCXILZCSQANSM-UHFFFAOYSA-N 3-[6-cyano-1-(2-naphthalen-1-ylpropanoyl)indol-3-yl]propanoic acid Chemical compound C1=CC=C2C(C(C(=O)N3C4=CC(=CC=C4C(CCC(O)=O)=C3)C#N)C)=CC=CC2=C1 GLCXILZCSQANSM-UHFFFAOYSA-N 0.000 claims 1
- BVPLXIBOATTYNJ-UHFFFAOYSA-N 3-[7-[(3-methyl-1-phenylbutyl)carbamoyl]-2,3-dihydroindol-1-yl]propanoic acid Chemical compound C=1C=CC=2CCN(CCC(O)=O)C=2C=1C(=O)NC(CC(C)C)C1=CC=CC=C1 BVPLXIBOATTYNJ-UHFFFAOYSA-N 0.000 claims 1
- OCLCKYWXXYGDFR-UHFFFAOYSA-N 3-[8-[(3-methyl-1-phenylbutyl)carbamoyl]-3,4-dihydro-2h-quinolin-1-yl]propanoic acid Chemical compound C=1C=CC=2CCCN(CCC(O)=O)C=2C=1C(=O)NC(CC(C)C)C1=CC=CC=C1 OCLCKYWXXYGDFR-UHFFFAOYSA-N 0.000 claims 1
- VQKVOQAQRWHGBO-UHFFFAOYSA-N 3-chloro-n-[2-[2-[3-[(3,4-difluorophenyl)sulfonylamino]-3-oxopropyl]-5-(pyrazol-1-ylmethyl)phenoxy]ethyl]benzamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCNC(=O)C=2C=C(Cl)C=CC=2)=CC=C1CN1N=CC=C1 VQKVOQAQRWHGBO-UHFFFAOYSA-N 0.000 claims 1
- JNOKSUZETRHXFU-UHFFFAOYSA-N 3-methoxy-n-[2-[2-[3-[(3-methoxyphenyl)sulfonylamino]-3-oxopropyl]-5-(pyrazol-1-ylmethyl)phenoxy]ethyl]benzamide Chemical compound COC1=CC=CC(C(=O)NCCOC=2C(=CC=C(CN3N=CC=C3)C=2)CCC(=O)NS(=O)(=O)C=2C=C(OC)C=CC=2)=C1 JNOKSUZETRHXFU-UHFFFAOYSA-N 0.000 claims 1
- FTHQIQALINOMHO-UHFFFAOYSA-N 3-methoxy-n-[2-[2-[3-[(3-methylphenyl)sulfonylamino]-3-oxopropyl]-5-(pyrazol-1-ylmethyl)phenoxy]ethyl]benzamide Chemical compound COC1=CC=CC(C(=O)NCCOC=2C(=CC=C(CN3N=CC=C3)C=2)CCC(=O)NS(=O)(=O)C=2C=C(C)C=CC=2)=C1 FTHQIQALINOMHO-UHFFFAOYSA-N 0.000 claims 1
- CQKAITCJPBUCGH-UHFFFAOYSA-N 3-methoxy-n-[2-[2-[3-[(3-nitrophenyl)sulfonylamino]-3-oxopropyl]-5-(pyrazol-1-ylmethyl)phenoxy]ethyl]benzamide Chemical compound COC1=CC=CC(C(=O)NCCOC=2C(=CC=C(CN3N=CC=C3)C=2)CCC(=O)NS(=O)(=O)C=2C=C(C=CC=2)[N+]([O-])=O)=C1 CQKAITCJPBUCGH-UHFFFAOYSA-N 0.000 claims 1
- UYFIKFGOTKGJMS-UHFFFAOYSA-N 3-methoxy-n-[2-[2-[3-[(4-methylphenyl)sulfonylamino]-3-oxopropyl]-5-(pyrazol-1-ylmethyl)phenoxy]ethyl]benzamide Chemical compound COC1=CC=CC(C(=O)NCCOC=2C(=CC=C(CN3N=CC=C3)C=2)CCC(=O)NS(=O)(=O)C=2C=CC(C)=CC=2)=C1 UYFIKFGOTKGJMS-UHFFFAOYSA-N 0.000 claims 1
- ZAZJYFGXYUVFKK-UHFFFAOYSA-N 3-methoxy-n-[2-[2-[3-oxo-3-[[3-(trifluoromethyl)phenyl]sulfonylamino]propyl]-5-(pyrazol-1-ylmethyl)phenoxy]ethyl]benzamide Chemical compound COC1=CC=CC(C(=O)NCCOC=2C(=CC=C(CN3N=CC=C3)C=2)CCC(=O)NS(=O)(=O)C=2C=C(C=CC=2)C(F)(F)F)=C1 ZAZJYFGXYUVFKK-UHFFFAOYSA-N 0.000 claims 1
- QFYAXBXYFPGSEP-UHFFFAOYSA-N 4-[(3-methyl-1-phenylbutyl)carbamoyl]-1-benzofuran-2-carboxylic acid Chemical compound C=1C=CC=2OC(C(O)=O)=CC=2C=1C(=O)NC(CC(C)C)C1=CC=CC=C1 QFYAXBXYFPGSEP-UHFFFAOYSA-N 0.000 claims 1
- XCGLQTYWKCCHKU-UHFFFAOYSA-N 4-[2-(1-naphthalen-1-ylpropylcarbamoyl)-4-phenoxyphenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(CC)NC(=O)C(C(=CC=1)CCCC(O)=O)=CC=1OC1=CC=CC=C1 XCGLQTYWKCCHKU-UHFFFAOYSA-N 0.000 claims 1
- GULPIFVRXVYDPB-UHFFFAOYSA-N 4-[2-(2-naphthalen-1-ylpropanoylamino)-4-(phenoxymethyl)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1COC1=CC=CC=C1 GULPIFVRXVYDPB-UHFFFAOYSA-N 0.000 claims 1
- LVJXXRMOBAYPLX-UHFFFAOYSA-N 4-[2-(2-naphthalen-1-ylpropanoylamino)-4-(phenylcarbamoyl)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1C(=O)NC1=CC=CC=C1 LVJXXRMOBAYPLX-UHFFFAOYSA-N 0.000 claims 1
- VMFJRGBSBLJFGY-UHFFFAOYSA-N 4-[2-(2-naphthalen-1-ylpropanoylamino)-4-(phenylmethoxymethyl)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1COCC1=CC=CC=C1 VMFJRGBSBLJFGY-UHFFFAOYSA-N 0.000 claims 1
- GKEZKOCHRVQYPJ-UHFFFAOYSA-N 4-[2-(2-naphthalen-1-ylpropanoylamino)-4-(phenylsulfanylmethyl)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1CSC1=CC=CC=C1 GKEZKOCHRVQYPJ-UHFFFAOYSA-N 0.000 claims 1
- KEJSFGFUXJGBQF-UHFFFAOYSA-N 4-[2-(2-naphthalen-1-ylpropanoylamino)-4-(pyridin-2-yloxymethyl)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1COC1=CC=CC=N1 KEJSFGFUXJGBQF-UHFFFAOYSA-N 0.000 claims 1
- TWNPCHLETHBOMG-UHFFFAOYSA-N 4-[2-(2-naphthalen-1-ylpropanoylamino)-4-(pyridin-3-yloxymethyl)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1COC1=CC=CN=C1 TWNPCHLETHBOMG-UHFFFAOYSA-N 0.000 claims 1
- VFLOZWSXVVKUBJ-UHFFFAOYSA-N 4-[2-(2-naphthalen-1-ylpropanoylamino)-4-[(2,4,6-trifluorophenoxy)methyl]phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1COC1=C(F)C=C(F)C=C1F VFLOZWSXVVKUBJ-UHFFFAOYSA-N 0.000 claims 1
- FWUWYXWNRABZCJ-UHFFFAOYSA-N 4-[2-(2-naphthalen-1-ylpropanoylamino)-4-[(2-oxopyridin-1-yl)methyl]phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1CN1C=CC=CC1=O FWUWYXWNRABZCJ-UHFFFAOYSA-N 0.000 claims 1
- NKULESNBRJUEME-UHFFFAOYSA-N 4-[2-(2-naphthalen-1-ylpropanoylamino)-4-[(2-propan-2-yloxyphenoxy)methyl]phenyl]butanoic acid Chemical compound CC(C)OC1=CC=CC=C1OCC1=CC=C(CCCC(O)=O)C(NC(=O)C(C)C=2C3=CC=CC=C3C=CC=2)=C1 NKULESNBRJUEME-UHFFFAOYSA-N 0.000 claims 1
- QGKOOABQMVPNFT-UHFFFAOYSA-N 4-[2-(2-naphthalen-1-ylpropanoylamino)-4-[(5-oxo-7,8-dihydro-6h-naphthalen-2-yl)oxymethyl]phenyl]butanoic acid Chemical compound C1=CC=C2C(C(C(=O)NC=3C(=CC=C(COC=4C=C5CCCC(=O)C5=CC=4)C=3)CCCC(O)=O)C)=CC=CC2=C1 QGKOOABQMVPNFT-UHFFFAOYSA-N 0.000 claims 1
- YQTSYPFUCASZNN-UHFFFAOYSA-N 4-[2-(2-naphthalen-1-ylpropanoylamino)-4-[[4-(1,2,4-triazol-1-yl)phenoxy]methyl]phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1COC(C=C1)=CC=C1N1C=NC=N1 YQTSYPFUCASZNN-UHFFFAOYSA-N 0.000 claims 1
- MPIXKAMXTUYFRF-UHFFFAOYSA-N 4-[2-(2-naphthalen-1-ylpropanoylamino)-4-[[4-(trifluoromethyl)phenyl]sulfanylmethyl]phenyl]butanoic acid Chemical compound C1(=CC=CC2=CC=CC=C12)C(C(=O)NC1=C(C=CC(=C1)CSC1=CC=C(C=C1)C(F)(F)F)CCCC(=O)O)C MPIXKAMXTUYFRF-UHFFFAOYSA-N 0.000 claims 1
- BYHUMBVKFMJJPQ-UHFFFAOYSA-N 4-[2-(2-naphthalen-1-ylpropanoylamino)-4-phenoxyphenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1OC1=CC=CC=C1 BYHUMBVKFMJJPQ-UHFFFAOYSA-N 0.000 claims 1
- KQIWYNIQEACBST-UHFFFAOYSA-N 4-[2-(2-naphthalen-1-ylpropanoylamino)-4-phenylmethoxyphenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1OCC1=CC=CC=C1 KQIWYNIQEACBST-UHFFFAOYSA-N 0.000 claims 1
- PMZQZDABBIZIOF-UHFFFAOYSA-N 4-[2-(2-naphthalen-1-ylpropanoylamino)-4-phenylphenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1C1=CC=CC=C1 PMZQZDABBIZIOF-UHFFFAOYSA-N 0.000 claims 1
- ONAGVLNKMZQLAH-UHFFFAOYSA-N 4-[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]butanoic acid Chemical compound C1=C(OCCC=2C=C3C=CC=CC3=CC=2)C(CCCC(=O)O)=CC=C1CN1C=CC=N1 ONAGVLNKMZQLAH-UHFFFAOYSA-N 0.000 claims 1
- QGDIYORNBOOXRW-UHFFFAOYSA-N 4-[2-[(3-methyl-1-naphthalen-1-ylbutyl)carbamoyl]-4-(phenoxymethyl)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCCC(O)=O)=CC=1COC1=CC=CC=C1 QGDIYORNBOOXRW-UHFFFAOYSA-N 0.000 claims 1
- FOKMKWHOJGERKB-UHFFFAOYSA-N 4-[2-[(3-methyl-1-naphthalen-1-ylbutyl)carbamoyl]-4-phenoxyphenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(CC(C)C)NC(=O)C(C(=CC=1)CCCC(O)=O)=CC=1OC1=CC=CC=C1 FOKMKWHOJGERKB-UHFFFAOYSA-N 0.000 claims 1
- XDOSAXDBHKDTGY-UHFFFAOYSA-N 4-[2-[(4-methyl-2-naphthalen-1-ylpentanoyl)amino]-4-(phenoxymethyl)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(CC(C)C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1COC1=CC=CC=C1 XDOSAXDBHKDTGY-UHFFFAOYSA-N 0.000 claims 1
- SOQGVGNUNTXGAF-UHFFFAOYSA-N 4-[2-[(4-methyl-2-naphthalen-1-ylpentanoyl)amino]-4-(pyrazol-1-ylmethyl)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(CC(C)C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1CN1C=CC=N1 SOQGVGNUNTXGAF-UHFFFAOYSA-N 0.000 claims 1
- PRONNXMHQCNNDX-UHFFFAOYSA-N 4-[2-[(4-methyl-2-naphthalen-1-ylpentanoyl)amino]-4-phenoxyphenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(CC(C)C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1OC1=CC=CC=C1 PRONNXMHQCNNDX-UHFFFAOYSA-N 0.000 claims 1
- BCVLTKWZKDIGQZ-UHFFFAOYSA-N 4-[2-[(4-methyl-2-phenylpentanoyl)amino]-4-phenoxyphenyl]butanoic acid Chemical compound C=1C=CC=CC=1C(CC(C)C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1OC1=CC=CC=C1 BCVLTKWZKDIGQZ-UHFFFAOYSA-N 0.000 claims 1
- CAINCQLTGLNWKW-UHFFFAOYSA-N 4-[2-[(4-naphthalen-1-yloxan-4-yl)carbamoyl]-4-phenoxyphenyl]butanoic acid Chemical compound C1=C(C(=O)NC2(CCOCC2)C=2C3=CC=CC=C3C=CC=2)C(CCCC(=O)O)=CC=C1OC1=CC=CC=C1 CAINCQLTGLNWKW-UHFFFAOYSA-N 0.000 claims 1
- CAFRDIXUIXWPMV-UHFFFAOYSA-N 4-[2-[2-(2-chlorophenyl)propanoylamino]-4-(phenoxymethyl)phenyl]butanoic acid Chemical compound C=1C=CC=C(Cl)C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1COC1=CC=CC=C1 CAFRDIXUIXWPMV-UHFFFAOYSA-N 0.000 claims 1
- PFMIWETVPIMNRB-UHFFFAOYSA-N 4-[2-[2-(4-chlorophenyl)propanoylamino]-4-(phenoxymethyl)phenyl]butanoic acid Chemical compound C=1C=C(Cl)C=CC=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1COC1=CC=CC=C1 PFMIWETVPIMNRB-UHFFFAOYSA-N 0.000 claims 1
- OZKUZHMZTIUNLH-UHFFFAOYSA-N 4-[2-[2-(4-fluoronaphthalen-1-yl)propanoylamino]-4-(phenoxymethyl)phenyl]butanoic acid Chemical compound C=1C=C(F)C2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1COC1=CC=CC=C1 OZKUZHMZTIUNLH-UHFFFAOYSA-N 0.000 claims 1
- PNIDTYCKEFEZOW-UHFFFAOYSA-N 4-[2-[2-(4-fluoronaphthalen-1-yl)propanoylamino]-4-(pyrazol-1-ylmethyl)phenyl]butanoic acid Chemical compound C=1C=C(F)C2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1CN1C=CC=N1 PNIDTYCKEFEZOW-UHFFFAOYSA-N 0.000 claims 1
- GZFQZTAKJOTQIA-UHFFFAOYSA-N 4-[2-[2-(4-fluorophenyl)propanoylamino]-4-(phenoxymethyl)phenyl]butanoic acid Chemical compound C=1C=C(F)C=CC=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1COC1=CC=CC=C1 GZFQZTAKJOTQIA-UHFFFAOYSA-N 0.000 claims 1
- GXBMUXYYEZWAMV-UHFFFAOYSA-N 4-[2-[2-(4-methoxyphenyl)propanoylamino]-4-(phenoxymethyl)phenyl]butanoic acid Chemical compound C1=CC(OC)=CC=C1C(C)C(=O)NC1=CC(COC=2C=CC=CC=2)=CC=C1CCCC(O)=O GXBMUXYYEZWAMV-UHFFFAOYSA-N 0.000 claims 1
- ZGSTUIGHLSKYQI-UHFFFAOYSA-N 4-[2-[2-(4-methylphenyl)propanoylamino]-4-(phenoxymethyl)phenyl]butanoic acid Chemical compound C=1C=C(C)C=CC=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1COC1=CC=CC=C1 ZGSTUIGHLSKYQI-UHFFFAOYSA-N 0.000 claims 1
- YTUXYXGOPSUTIL-LJQANCHMSA-N 4-[2-[[(1r)-1-naphthalen-1-ylethyl]carbamoyl]-4-(2-nitrophenoxy)phenyl]butanoic acid Chemical compound N([C@H](C)C=1C2=CC=CC=C2C=CC=1)C(=O)C(C(=CC=1)CCCC(O)=O)=CC=1OC1=CC=CC=C1[N+]([O-])=O YTUXYXGOPSUTIL-LJQANCHMSA-N 0.000 claims 1
- URLKMSTWYSOALI-LJQANCHMSA-N 4-[2-[[(1r)-1-naphthalen-1-ylethyl]carbamoyl]-4-(4-nitrophenoxy)phenyl]butanoic acid Chemical compound N([C@H](C)C=1C2=CC=CC=C2C=CC=1)C(=O)C(C(=CC=1)CCCC(O)=O)=CC=1OC1=CC=C([N+]([O-])=O)C=C1 URLKMSTWYSOALI-LJQANCHMSA-N 0.000 claims 1
- GNMQMHNTRICULH-HXUWFJFHSA-N 4-[2-[[(1r)-1-naphthalen-1-ylethyl]carbamoyl]-4-phenoxyphenyl]butanoic acid Chemical compound N([C@H](C)C=1C2=CC=CC=C2C=CC=1)C(=O)C(C(=CC=1)CCCC(O)=O)=CC=1OC1=CC=CC=C1 GNMQMHNTRICULH-HXUWFJFHSA-N 0.000 claims 1
- VGWSFEYNMXESGK-LJQANCHMSA-N 4-[2-[[(1r)-1-naphthalen-1-ylethyl]carbamoyl]-4-pyridin-2-yloxyphenyl]butanoic acid Chemical compound N([C@H](C)C=1C2=CC=CC=C2C=CC=1)C(=O)C(C(=CC=1)CCCC(O)=O)=CC=1OC1=CC=CC=N1 VGWSFEYNMXESGK-LJQANCHMSA-N 0.000 claims 1
- KDCCVMNYHOQQHB-UHFFFAOYSA-N 4-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-phenoxyphenyl]butanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCCC(O)=O)=CC=1OC1=CC=CC=C1 KDCCVMNYHOQQHB-UHFFFAOYSA-N 0.000 claims 1
- DVYZHMUEJDJYEC-UHFFFAOYSA-N 4-[2-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-4-phenylmethoxyphenyl]butanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCCC(O)=O)=CC=1OCC1=CC=CC=C1 DVYZHMUEJDJYEC-UHFFFAOYSA-N 0.000 claims 1
- MTGGPMDXYWANIZ-UHFFFAOYSA-N 4-[2-[[1-(4-fluoro-3-methylphenyl)-3-methylbutyl]carbamoyl]-4-phenoxyphenyl]butanoic acid Chemical compound C=1C=C(F)C(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCCC(O)=O)=CC=1OC1=CC=CC=C1 MTGGPMDXYWANIZ-UHFFFAOYSA-N 0.000 claims 1
- NFLRJXDECRAYKB-UHFFFAOYSA-N 4-[2-[[4-(3,5-dimethylphenyl)oxan-4-yl]carbamoyl]-4-phenoxyphenyl]butanoic acid Chemical compound CC1=CC(C)=CC(C2(CCOCC2)NC(=O)C=2C(=CC=C(OC=3C=CC=CC=3)C=2)CCCC(O)=O)=C1 NFLRJXDECRAYKB-UHFFFAOYSA-N 0.000 claims 1
- MBJDAKZAFYYIQG-UHFFFAOYSA-N 4-[3-[(3-cyanophenoxy)methyl]-5-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]phenyl]butanoic acid Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C=1)=CC(CCCC(O)=O)=CC=1COC1=CC=CC(C#N)=C1 MBJDAKZAFYYIQG-UHFFFAOYSA-N 0.000 claims 1
- XUOFDXPMEQAHGX-HXUWFJFHSA-N 4-[4-(2-acetamidophenoxy)-2-[[(1r)-1-naphthalen-1-ylethyl]carbamoyl]phenyl]butanoic acid Chemical compound N([C@H](C)C=1C2=CC=CC=C2C=CC=1)C(=O)C(C(=CC=1)CCCC(O)=O)=CC=1OC1=CC=CC=C1NC(C)=O XUOFDXPMEQAHGX-HXUWFJFHSA-N 0.000 claims 1
- YWWJZCDAJVEHBA-HXUWFJFHSA-N 4-[4-(2-acetylphenoxy)-2-[[(1r)-1-naphthalen-1-ylethyl]carbamoyl]phenyl]butanoic acid Chemical compound N([C@H](C)C=1C2=CC=CC=C2C=CC=1)C(=O)C(C(=CC=1)CCCC(O)=O)=CC=1OC1=CC=CC=C1C(C)=O YWWJZCDAJVEHBA-HXUWFJFHSA-N 0.000 claims 1
- MAAYVELOJHTOMN-LJQANCHMSA-N 4-[4-(2-aminophenoxy)-2-[[(1r)-1-naphthalen-1-ylethyl]carbamoyl]phenyl]butanoic acid Chemical compound N([C@H](C)C=1C2=CC=CC=C2C=CC=1)C(=O)C(C(=CC=1)CCCC(O)=O)=CC=1OC1=CC=CC=C1N MAAYVELOJHTOMN-LJQANCHMSA-N 0.000 claims 1
- KOOPHHLADINYRP-HXUWFJFHSA-N 4-[4-(2-cyanophenoxy)-2-[[(1r)-1-naphthalen-1-ylethyl]carbamoyl]phenyl]butanoic acid Chemical compound N([C@H](C)C=1C2=CC=CC=C2C=CC=1)C(=O)C(C(=CC=1)CCCC(O)=O)=CC=1OC1=CC=CC=C1C#N KOOPHHLADINYRP-HXUWFJFHSA-N 0.000 claims 1
- WESHJYSVNWNVKA-LJQANCHMSA-N 4-[4-(2-fluorophenoxy)-2-[[(1r)-1-naphthalen-1-ylethyl]carbamoyl]phenyl]butanoic acid Chemical compound N([C@H](C)C=1C2=CC=CC=C2C=CC=1)C(=O)C(C(=CC=1)CCCC(O)=O)=CC=1OC1=CC=CC=C1F WESHJYSVNWNVKA-LJQANCHMSA-N 0.000 claims 1
- IPLSCPLCTDPORM-LJQANCHMSA-N 4-[4-(3-fluorophenoxy)-2-[[(1r)-1-naphthalen-1-ylethyl]carbamoyl]phenyl]butanoic acid Chemical compound N([C@H](C)C=1C2=CC=CC=C2C=CC=1)C(=O)C(C(=CC=1)CCCC(O)=O)=CC=1OC1=CC=CC(F)=C1 IPLSCPLCTDPORM-LJQANCHMSA-N 0.000 claims 1
- SOIPSEXZXLSRNW-HXUWFJFHSA-N 4-[4-(3-methoxyphenoxy)-2-[[(1r)-1-naphthalen-1-ylethyl]carbamoyl]phenyl]butanoic acid Chemical compound COC1=CC=CC(OC=2C=C(C(CCCC(O)=O)=CC=2)C(=O)N[C@H](C)C=2C3=CC=CC=C3C=CC=2)=C1 SOIPSEXZXLSRNW-HXUWFJFHSA-N 0.000 claims 1
- OWDDZMBVXCHNIP-HXUWFJFHSA-N 4-[4-(4-acetamidophenoxy)-2-[[(1r)-1-naphthalen-1-ylethyl]carbamoyl]phenyl]butanoic acid Chemical compound N([C@H](C)C=1C2=CC=CC=C2C=CC=1)C(=O)C(C(=CC=1)CCCC(O)=O)=CC=1OC1=CC=C(NC(C)=O)C=C1 OWDDZMBVXCHNIP-HXUWFJFHSA-N 0.000 claims 1
- CGKOEGPDRYQHKP-HXUWFJFHSA-N 4-[4-(4-acetylphenoxy)-2-[[(1r)-1-naphthalen-1-ylethyl]carbamoyl]phenyl]butanoic acid Chemical compound N([C@H](C)C=1C2=CC=CC=C2C=CC=1)C(=O)C(C(=CC=1)CCCC(O)=O)=CC=1OC1=CC=C(C(C)=O)C=C1 CGKOEGPDRYQHKP-HXUWFJFHSA-N 0.000 claims 1
- BPVGVPHOWJTALR-LJQANCHMSA-N 4-[4-(4-aminophenoxy)-2-[[(1r)-1-naphthalen-1-ylethyl]carbamoyl]phenyl]butanoic acid Chemical compound N([C@H](C)C=1C2=CC=CC=C2C=CC=1)C(=O)C(C(=CC=1)CCCC(O)=O)=CC=1OC1=CC=C(N)C=C1 BPVGVPHOWJTALR-LJQANCHMSA-N 0.000 claims 1
- LGJWEWHXTOLMIA-LJQANCHMSA-N 4-[4-(4-carbamoylphenoxy)-2-[[(1r)-1-naphthalen-1-ylethyl]carbamoyl]phenyl]butanoic acid Chemical compound N([C@H](C)C=1C2=CC=CC=C2C=CC=1)C(=O)C(C(=CC=1)CCCC(O)=O)=CC=1OC1=CC=C(C(N)=O)C=C1 LGJWEWHXTOLMIA-LJQANCHMSA-N 0.000 claims 1
- ILECWJQUGWBGFR-HXUWFJFHSA-N 4-[4-(4-cyanophenoxy)-2-[[(1r)-1-naphthalen-1-ylethyl]carbamoyl]phenyl]butanoic acid Chemical compound N([C@H](C)C=1C2=CC=CC=C2C=CC=1)C(=O)C(C(=CC=1)CCCC(O)=O)=CC=1OC1=CC=C(C#N)C=C1 ILECWJQUGWBGFR-HXUWFJFHSA-N 0.000 claims 1
- BVBOYIBGQRMPJV-LJQANCHMSA-N 4-[4-(4-fluorophenoxy)-2-[[(1r)-1-naphthalen-1-ylethyl]carbamoyl]phenyl]butanoic acid Chemical compound N([C@H](C)C=1C2=CC=CC=C2C=CC=1)C(=O)C(C(=CC=1)CCCC(O)=O)=CC=1OC1=CC=C(F)C=C1 BVBOYIBGQRMPJV-LJQANCHMSA-N 0.000 claims 1
- AIMORUKIWPLICM-HXUWFJFHSA-N 4-[4-(4-methoxyphenoxy)-2-[[(1r)-1-naphthalen-1-ylethyl]carbamoyl]phenyl]butanoic acid Chemical compound C1=CC(OC)=CC=C1OC1=CC=C(CCCC(O)=O)C(C(=O)N[C@H](C)C=2C3=CC=CC=C3C=CC=2)=C1 AIMORUKIWPLICM-HXUWFJFHSA-N 0.000 claims 1
- ZLZHWVBNPFPJMV-HXUWFJFHSA-N 4-[4-(4-methylsulfonylphenoxy)-2-[[(1r)-1-naphthalen-1-ylethyl]carbamoyl]phenyl]butanoic acid Chemical compound N([C@H](C)C=1C2=CC=CC=C2C=CC=1)C(=O)C(C(=CC=1)CCCC(O)=O)=CC=1OC1=CC=C(S(C)(=O)=O)C=C1 ZLZHWVBNPFPJMV-HXUWFJFHSA-N 0.000 claims 1
- QAFKSANHYOYZRC-UHFFFAOYSA-N 4-[4-(acetamidomethyl)-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC1=CC(CNC(C)=O)=CC=C1CCCC(O)=O QAFKSANHYOYZRC-UHFFFAOYSA-N 0.000 claims 1
- KHMJPMYQKKDJCO-UHFFFAOYSA-N 4-[4-(aminomethyl)-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC1=CC(CN)=CC=C1CCCC(O)=O KHMJPMYQKKDJCO-UHFFFAOYSA-N 0.000 claims 1
- FORQCLNVDBTNEW-UHFFFAOYSA-N 4-[4-(anilinomethyl)-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1CNC1=CC=CC=C1 FORQCLNVDBTNEW-UHFFFAOYSA-N 0.000 claims 1
- YSTVYXWDHCKDFY-UHFFFAOYSA-N 4-[4-(anilinomethyl)-2-[2-(4-fluoronaphthalen-1-yl)propanoylamino]phenyl]butanoic acid Chemical compound C=1C=C(F)C2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1CNC1=CC=CC=C1 YSTVYXWDHCKDFY-UHFFFAOYSA-N 0.000 claims 1
- GALSVYGBJDJYEQ-UHFFFAOYSA-N 4-[4-(benzamidomethyl)-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1CNC(=O)C1=CC=CC=C1 GALSVYGBJDJYEQ-UHFFFAOYSA-N 0.000 claims 1
- LCCDNOGNZHPXJI-UHFFFAOYSA-N 4-[4-(benzamidomethyl)-2-(2-phenylpropanoylamino)phenyl]butanoic acid Chemical compound C=1C=CC=CC=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1CNC(=O)C1=CC=CC=C1 LCCDNOGNZHPXJI-UHFFFAOYSA-N 0.000 claims 1
- SMEAGGVXOKGSKP-UHFFFAOYSA-N 4-[4-(benzamidomethyl)-2-[2-(4-fluoronaphthalen-1-yl)propanoylamino]phenyl]butanoic acid Chemical compound C=1C=C(F)C2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1CNC(=O)C1=CC=CC=C1 SMEAGGVXOKGSKP-UHFFFAOYSA-N 0.000 claims 1
- CUSBYPJNYUQNAH-UHFFFAOYSA-N 4-[4-(benzenesulfonamido)-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1NS(=O)(=O)C1=CC=CC=C1 CUSBYPJNYUQNAH-UHFFFAOYSA-N 0.000 claims 1
- LFMPMODPEMENKE-UHFFFAOYSA-N 4-[4-(benzylcarbamoyl)-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1C(=O)NCC1=CC=CC=C1 LFMPMODPEMENKE-UHFFFAOYSA-N 0.000 claims 1
- LJPJXFKNLDZEPJ-UHFFFAOYSA-N 4-[4-(hydroxymethyl)-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC1=CC(CO)=CC=C1CCCC(O)=O LJPJXFKNLDZEPJ-UHFFFAOYSA-N 0.000 claims 1
- ZACFMOAZNODACR-UHFFFAOYSA-N 4-[4-(methoxymethyl)-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound COCC1=CC=C(CCCC(O)=O)C(NC(=O)C(C)C=2C3=CC=CC=C3C=CC=2)=C1 ZACFMOAZNODACR-UHFFFAOYSA-N 0.000 claims 1
- CZUFVJPBZBDRER-UHFFFAOYSA-N 4-[4-(methylsulfanylmethyl)-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound CSCC1=CC=C(CCCC(O)=O)C(NC(=O)C(C)C=2C3=CC=CC=C3C=CC=2)=C1 CZUFVJPBZBDRER-UHFFFAOYSA-N 0.000 claims 1
- RCHIDLNKKFKSBN-UHFFFAOYSA-N 4-[4-(methylsulfinylmethyl)-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC1=CC(CS(C)=O)=CC=C1CCCC(O)=O RCHIDLNKKFKSBN-UHFFFAOYSA-N 0.000 claims 1
- DPNUZIOMXQDTGM-UHFFFAOYSA-N 4-[4-(methylsulfonylmethyl)-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC1=CC(CS(C)(=O)=O)=CC=C1CCCC(O)=O DPNUZIOMXQDTGM-UHFFFAOYSA-N 0.000 claims 1
- MCNDYTIJSCBBTC-UHFFFAOYSA-N 4-[4-(phenoxymethyl)-2-(2-phenylpropanoylamino)phenyl]butanoic acid Chemical compound C=1C=CC=CC=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1COC1=CC=CC=C1 MCNDYTIJSCBBTC-UHFFFAOYSA-N 0.000 claims 1
- MNDPPHHNEDWPIW-UHFFFAOYSA-N 4-[4-[(2-chloro-4,5-dimethylphenoxy)methyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1COC1=CC(C)=C(C)C=C1Cl MNDPPHHNEDWPIW-UHFFFAOYSA-N 0.000 claims 1
- ZOQVHZYSCUQMKY-UHFFFAOYSA-N 4-[4-[(2-fluoro-6-methoxyphenoxy)methyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound COC1=CC=CC(F)=C1OCC1=CC=C(CCCC(O)=O)C(NC(=O)C(C)C=2C3=CC=CC=C3C=CC=2)=C1 ZOQVHZYSCUQMKY-UHFFFAOYSA-N 0.000 claims 1
- QFFUTDRVQOGJCA-UHFFFAOYSA-N 4-[4-[(2-methoxy-5-methylphenoxy)methyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound COC1=CC=C(C)C=C1OCC1=CC=C(CCCC(O)=O)C(NC(=O)C(C)C=2C3=CC=CC=C3C=CC=2)=C1 QFFUTDRVQOGJCA-UHFFFAOYSA-N 0.000 claims 1
- UKDMKXCKZISHSS-UHFFFAOYSA-N 4-[4-[(2-methoxyphenoxy)methyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound COC1=CC=CC=C1OCC1=CC=C(CCCC(O)=O)C(NC(=O)C(C)C=2C3=CC=CC=C3C=CC=2)=C1 UKDMKXCKZISHSS-UHFFFAOYSA-N 0.000 claims 1
- BZRVHDXQCDQRFZ-UHFFFAOYSA-N 4-[4-[(2-methyl-1,3-benzothiazol-5-yl)oxymethyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound C1=CC=C2C(C(C(=O)NC=3C(=CC=C(COC=4C=C5N=C(C)SC5=CC=4)C=3)CCCC(O)=O)C)=CC=CC2=C1 BZRVHDXQCDQRFZ-UHFFFAOYSA-N 0.000 claims 1
- DUCUDJAGTFSPKD-UHFFFAOYSA-N 4-[4-[(3,5-dimethoxyphenoxy)methyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound COC1=CC(OC)=CC(OCC=2C=C(NC(=O)C(C)C=3C4=CC=CC=C4C=CC=3)C(CCCC(O)=O)=CC=2)=C1 DUCUDJAGTFSPKD-UHFFFAOYSA-N 0.000 claims 1
- TVCVHOVYYRQMOE-UHFFFAOYSA-N 4-[4-[(3-acetylphenoxy)methyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1COC1=CC=CC(C(C)=O)=C1 TVCVHOVYYRQMOE-UHFFFAOYSA-N 0.000 claims 1
- KNSZSJLIPJAOKH-UHFFFAOYSA-N 4-[4-[(3-chloro-5-methoxyphenoxy)methyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound COC1=CC(Cl)=CC(OCC=2C=C(NC(=O)C(C)C=3C4=CC=CC=C4C=CC=3)C(CCCC(O)=O)=CC=2)=C1 KNSZSJLIPJAOKH-UHFFFAOYSA-N 0.000 claims 1
- NUIPQSZDNTWPDR-UHFFFAOYSA-N 4-[4-[(3-cyanophenoxy)methyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1COC1=CC=CC(C#N)=C1 NUIPQSZDNTWPDR-UHFFFAOYSA-N 0.000 claims 1
- ILBBWMZEJLDPKZ-UHFFFAOYSA-N 4-[4-[(3-cyanophenoxy)methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]-n-(3,4-difluorophenyl)sulfonylbutanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1COC1=CC=CC(C#N)=C1 ILBBWMZEJLDPKZ-UHFFFAOYSA-N 0.000 claims 1
- DLEOTFMVCYOXDG-UHFFFAOYSA-N 4-[4-[(3-cyanophenoxy)methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]butanoic acid Chemical compound C1=C(OCCC=2C=C3C=CC=CC3=CC=2)C(CCCC(=O)O)=CC=C1COC1=CC=CC(C#N)=C1 DLEOTFMVCYOXDG-UHFFFAOYSA-N 0.000 claims 1
- SAKPMZWMQLGZBQ-UHFFFAOYSA-N 4-[4-[(3-cyanophenoxy)methyl]-2-(2-phenylethoxy)phenyl]-n-(3,4-difluorophenyl)sulfonylbutanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCCC(C(=C1)OCCC=2C=CC=CC=2)=CC=C1COC1=CC=CC(C#N)=C1 SAKPMZWMQLGZBQ-UHFFFAOYSA-N 0.000 claims 1
- LKQAHPNSXJWLRM-UHFFFAOYSA-N 4-[4-[(3-cyanophenoxy)methyl]-2-(2-phenylethoxy)phenyl]butanoic acid Chemical compound C1=C(OCCC=2C=CC=CC=2)C(CCCC(=O)O)=CC=C1COC1=CC=CC(C#N)=C1 LKQAHPNSXJWLRM-UHFFFAOYSA-N 0.000 claims 1
- OURCFDSDGKQAKQ-UHFFFAOYSA-N 4-[4-[(3-fluorophenoxy)methyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1COC1=CC=CC(F)=C1 OURCFDSDGKQAKQ-UHFFFAOYSA-N 0.000 claims 1
- HNFLMPPLGDMHEP-UHFFFAOYSA-N 4-[4-[(3-methoxyphenoxy)methyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound COC1=CC=CC(OCC=2C=C(NC(=O)C(C)C=3C4=CC=CC=C4C=CC=3)C(CCCC(O)=O)=CC=2)=C1 HNFLMPPLGDMHEP-UHFFFAOYSA-N 0.000 claims 1
- JLTIDDLJJISPIO-UHFFFAOYSA-N 4-[4-[(3-methyl-5-propan-2-ylphenoxy)methyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound CC(C)C1=CC(C)=CC(OCC=2C=C(NC(=O)C(C)C=3C4=CC=CC=C4C=CC=3)C(CCCC(O)=O)=CC=2)=C1 JLTIDDLJJISPIO-UHFFFAOYSA-N 0.000 claims 1
- GPCYOPOAUILIHS-UHFFFAOYSA-N 4-[4-[(4-acetamido-2-chlorophenoxy)methyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1COC1=CC=C(NC(C)=O)C=C1Cl GPCYOPOAUILIHS-UHFFFAOYSA-N 0.000 claims 1
- DWKSLRLEAKGCHW-UHFFFAOYSA-N 4-[4-[(4-bromophenoxy)methyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1COC1=CC=C(Br)C=C1 DWKSLRLEAKGCHW-UHFFFAOYSA-N 0.000 claims 1
- UYEHPPAGMOXOHS-UHFFFAOYSA-N 4-[4-[(4-cyano-2-methoxyphenoxy)methyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound COC1=CC(C#N)=CC=C1OCC1=CC=C(CCCC(O)=O)C(NC(=O)C(C)C=2C3=CC=CC=C3C=CC=2)=C1 UYEHPPAGMOXOHS-UHFFFAOYSA-N 0.000 claims 1
- FAIJCBDKRNKFGB-UHFFFAOYSA-N 4-[4-[(4-cyanophenoxy)methyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1COC1=CC=C(C#N)C=C1 FAIJCBDKRNKFGB-UHFFFAOYSA-N 0.000 claims 1
- RYUZEJOOEKUPSY-UHFFFAOYSA-N 4-[4-[(4-ethyl-2-methoxyphenoxy)methyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound COC1=CC(CC)=CC=C1OCC1=CC=C(CCCC(O)=O)C(NC(=O)C(C)C=2C3=CC=CC=C3C=CC=2)=C1 RYUZEJOOEKUPSY-UHFFFAOYSA-N 0.000 claims 1
- NLPMLOFTOGGEJD-UHFFFAOYSA-N 4-[4-[(cyclopropanecarbonylamino)methyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1CNC(=O)C1CC1 NLPMLOFTOGGEJD-UHFFFAOYSA-N 0.000 claims 1
- IDEYTZRYSCCBSR-UHFFFAOYSA-N 4-[4-[(ethoxycarbonylamino)methyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound CCOC(=O)NCC1=CC=C(CCCC(O)=O)C(NC(=O)C(C)C=2C3=CC=CC=C3C=CC=2)=C1 IDEYTZRYSCCBSR-UHFFFAOYSA-N 0.000 claims 1
- BQOJAYCYZMKMJK-UHFFFAOYSA-N 4-[4-[(furan-2-carbonylamino)methyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1CNC(=O)C1=CC=CO1 BQOJAYCYZMKMJK-UHFFFAOYSA-N 0.000 claims 1
- BKAGYCORMGQMGY-HXUWFJFHSA-N 4-[4-[2-(methanesulfonamido)phenoxy]-2-[[(1r)-1-naphthalen-1-ylethyl]carbamoyl]phenyl]butanoic acid Chemical compound N([C@H](C)C=1C2=CC=CC=C2C=CC=1)C(=O)C(C(=CC=1)CCCC(O)=O)=CC=1OC1=CC=CC=C1NS(C)(=O)=O BKAGYCORMGQMGY-HXUWFJFHSA-N 0.000 claims 1
- XPKGVBOLWGPJIH-HXUWFJFHSA-N 4-[4-[4-(methanesulfonamido)phenoxy]-2-[[(1r)-1-naphthalen-1-ylethyl]carbamoyl]phenyl]butanoic acid Chemical compound N([C@H](C)C=1C2=CC=CC=C2C=CC=1)C(=O)C(C(=CC=1)CCCC(O)=O)=CC=1OC1=CC=C(NS(C)(=O)=O)C=C1 XPKGVBOLWGPJIH-HXUWFJFHSA-N 0.000 claims 1
- ZPOIZNZRBLAGFM-UHFFFAOYSA-N 4-[4-[[(3,5-difluorobenzoyl)amino]methyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1CNC(=O)C1=CC(F)=CC(F)=C1 ZPOIZNZRBLAGFM-UHFFFAOYSA-N 0.000 claims 1
- KUHSBVGVJPEGSZ-UHFFFAOYSA-N 4-[4-[[(3-chloro-4-fluorobenzoyl)amino]methyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1CNC(=O)C1=CC=C(F)C(Cl)=C1 KUHSBVGVJPEGSZ-UHFFFAOYSA-N 0.000 claims 1
- JPRNZYPDSSSJJQ-UHFFFAOYSA-N 4-[4-[[(3-chlorobenzoyl)amino]methyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1CNC(=O)C1=CC=CC(Cl)=C1 JPRNZYPDSSSJJQ-UHFFFAOYSA-N 0.000 claims 1
- OCBYVNLURXWPRL-UHFFFAOYSA-N 4-[4-[[(3-ethoxybenzoyl)amino]methyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound CCOC1=CC=CC(C(=O)NCC=2C=C(NC(=O)C(C)C=3C4=CC=CC=C4C=CC=3)C(CCCC(O)=O)=CC=2)=C1 OCBYVNLURXWPRL-UHFFFAOYSA-N 0.000 claims 1
- ZLLKCQNIHIKQJP-UHFFFAOYSA-N 4-[4-[[(3-fluorobenzoyl)amino]methyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1CNC(=O)C1=CC=CC(F)=C1 ZLLKCQNIHIKQJP-UHFFFAOYSA-N 0.000 claims 1
- YPZSQCHWOBMPKG-UHFFFAOYSA-N 4-[4-[[(3-methoxybenzoyl)amino]methyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound COC1=CC=CC(C(=O)NCC=2C=C(NC(=O)C(C)C=3C4=CC=CC=C4C=CC=3)C(CCCC(O)=O)=CC=2)=C1 YPZSQCHWOBMPKG-UHFFFAOYSA-N 0.000 claims 1
- LIWHPSFQBLKCNS-UHFFFAOYSA-N 4-[4-[[(4-fluorobenzoyl)amino]methyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1CNC(=O)C1=CC=C(F)C=C1 LIWHPSFQBLKCNS-UHFFFAOYSA-N 0.000 claims 1
- RYZKBPFMTAJTQD-UHFFFAOYSA-N 4-[4-[[methyl(methylsulfonyl)amino]methyl]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC1=CC(CN(C)S(C)(=O)=O)=CC=C1CCCC(O)=O RYZKBPFMTAJTQD-UHFFFAOYSA-N 0.000 claims 1
- HVKCQFPPYPIBAO-UHFFFAOYSA-N 4-[4-[benzoyl(methyl)amino]-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1N(C)C(=O)C1=CC=CC=C1 HVKCQFPPYPIBAO-UHFFFAOYSA-N 0.000 claims 1
- NNVUKPRYRAWMOC-UHFFFAOYSA-N 4-[4-benzamido-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoic acid Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)NC(C(=CC=1)CCCC(O)=O)=CC=1NC(=O)C1=CC=CC=C1 NNVUKPRYRAWMOC-UHFFFAOYSA-N 0.000 claims 1
- FBGOTOMPTZQIIH-UHFFFAOYSA-N 4-[4-cyano-2-(naphthalene-1-carbonylamino)phenyl]butanoic acid Chemical compound OC(=O)CCCC1=CC=C(C#N)C=C1NC(=O)C1=CC=CC2=CC=CC=C12 FBGOTOMPTZQIIH-UHFFFAOYSA-N 0.000 claims 1
- PDUNMBJGQUPICB-HXUWFJFHSA-N 4-[4-cyclohexyloxy-2-[[(1r)-1-naphthalen-1-ylethyl]carbamoyl]phenyl]butanoic acid Chemical compound N([C@H](C)C=1C2=CC=CC=C2C=CC=1)C(=O)C(C(=CC=1)CCCC(O)=O)=CC=1OC1CCCCC1 PDUNMBJGQUPICB-HXUWFJFHSA-N 0.000 claims 1
- VQLLZCGNJKTGQK-UHFFFAOYSA-N 5-[(2-chloro-5-methylphenoxy)methyl]-2-[3-[(3,4-difluorophenyl)sulfonylamino]-3-oxopropyl]-n-[1-(3,5-dimethylphenyl)-3-methylbutyl]benzamide Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(=O)NS(=O)(=O)C=2C=C(F)C(F)=CC=2)=CC=1COC1=CC(C)=CC=C1Cl VQLLZCGNJKTGQK-UHFFFAOYSA-N 0.000 claims 1
- UNBGSDYWUKZSAE-UHFFFAOYSA-N 5-[(2-chloro-5-methylphenoxy)methyl]-n-[1-(3,5-dimethylphenyl)-3-methylbutyl]-2-[3-oxo-3-(2h-tetrazol-5-ylamino)propyl]benzamide Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(=O)NC=2NN=NN=2)=CC=1COC1=CC(C)=CC=C1Cl UNBGSDYWUKZSAE-UHFFFAOYSA-N 0.000 claims 1
- MTTNAEDSYZQCRD-UHFFFAOYSA-N 5-[(3-cyanophenoxy)methyl]-2-[3-[(3,4-difluorophenyl)sulfonylamino]-3-oxopropyl]-n-[1-(3,5-dimethylphenyl)-3-methylbutyl]benzamide Chemical compound C=1C(C)=CC(C)=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(=O)NS(=O)(=O)C=2C=C(F)C(F)=CC=2)=CC=1COC1=CC=CC(C#N)=C1 MTTNAEDSYZQCRD-UHFFFAOYSA-N 0.000 claims 1
- XDBLERHJZKTNCH-UHFFFAOYSA-N 5-cyano-2-[3-[(3,4-difluorophenyl)sulfonylamino]-3-oxopropyl]-n-(3-methyl-1-phenylbutyl)benzamide Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C1=CC(C#N)=CC=C1CCC(=O)NS(=O)(=O)C1=CC=C(F)C(F)=C1 XDBLERHJZKTNCH-UHFFFAOYSA-N 0.000 claims 1
- YDMCFZSFOUNQQA-UHFFFAOYSA-N 7-(2-naphthalen-1-ylpropanoylamino)-1-benzofuran-2-carboxylic acid Chemical compound C1=CC=C2C(C(C(=O)NC=3C=4OC(=CC=4C=CC=3)C(O)=O)C)=CC=CC2=C1 YDMCFZSFOUNQQA-UHFFFAOYSA-N 0.000 claims 1
- OOAXFHVFORIUKP-UHFFFAOYSA-N 7-[(2-naphthalen-1-ylacetyl)amino]-1-benzofuran-2-carboxylic acid Chemical compound C1=CC=C2C(CC(=O)NC=3C=CC=C4C=C(OC4=3)C(=O)O)=CC=CC2=C1 OOAXFHVFORIUKP-UHFFFAOYSA-N 0.000 claims 1
- YYQSYJWJMVLKLF-UHFFFAOYSA-N 7-[(3-methyl-1-phenylbutyl)carbamoyl]-1-benzofuran-2-carboxylic acid Chemical compound C=1C=CC=2C=C(C(O)=O)OC=2C=1C(=O)NC(CC(C)C)C1=CC=CC=C1 YYQSYJWJMVLKLF-UHFFFAOYSA-N 0.000 claims 1
- NVVHXEUDIQYUGJ-UHFFFAOYSA-N 7-[(3-methyl-1-phenylbutyl)carbamoyl]naphthalene-1-carboxylic acid Chemical compound C=1C=C2C=CC=C(C(O)=O)C2=CC=1C(=O)NC(CC(C)C)C1=CC=CC=C1 NVVHXEUDIQYUGJ-UHFFFAOYSA-N 0.000 claims 1
- IIBNCTHXEKNUCW-UHFFFAOYSA-N 7-[(4-methyl-2-naphthalen-1-ylpentanoyl)amino]-1-benzofuran-2-carboxylic acid Chemical compound C1=CC=C2C(C(C(=O)NC=3C=4OC(=CC=4C=CC=3)C(O)=O)CC(C)C)=CC=CC2=C1 IIBNCTHXEKNUCW-UHFFFAOYSA-N 0.000 claims 1
- YFXYRASHZYIUHU-UHFFFAOYSA-N 7-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]-1-benzofuran-2-carboxylic acid Chemical compound C=1C=CC=2C=C(C(O)=O)OC=2C=1C(=O)NC(CC(C)C)C1=CC(C)=CC(C)=C1 YFXYRASHZYIUHU-UHFFFAOYSA-N 0.000 claims 1
- OJOULGRPSICUCV-UHFFFAOYSA-N 8-[[1-(3,5-dimethylphenyl)-3-methylbutyl]carbamoyl]naphthalene-2-carboxylic acid Chemical compound C=1C=CC2=CC=C(C(O)=O)C=C2C=1C(=O)NC(CC(C)C)C1=CC(C)=CC(C)=C1 OJOULGRPSICUCV-UHFFFAOYSA-N 0.000 claims 1
- ISSYRMYDBRHJAI-UHFFFAOYSA-N N-(3,4-difluorophenyl)sulfonyl-2-[4-[(2-methyl-3H-pyrazol-1-yl)methyl]-2-(2-naphthalen-2-ylethoxy)anilino]acetamide Chemical compound CN1CC=CN1CC(C=C1OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1NCC(=O)NS(=O)(=O)C1=CC=C(F)C(F)=C1 ISSYRMYDBRHJAI-UHFFFAOYSA-N 0.000 claims 1
- 101150109738 Ptger4 gene Proteins 0.000 claims 1
- LALFFDYTAUBMAP-UHFFFAOYSA-N [4-[3-[(3,4-difluorophenyl)sulfonylamino]-3-oxopropyl]-3-[(3-methyl-1-phenylbutyl)carbamoyl]phenyl] propane-2-sulfonate Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C1=CC(OS(=O)(=O)C(C)C)=CC=C1CCC(=O)NS(=O)(=O)C1=CC=C(F)C(F)=C1 LALFFDYTAUBMAP-UHFFFAOYSA-N 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- XJMKGRLNFHPTBO-UHFFFAOYSA-N methyl 2-[3-[2-[[1-(4-fluorophenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoylsulfamoyl]benzoate Chemical compound COC(=O)C1=CC=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)C(=O)NC(CC(C)C)C=2C=CC(F)=CC=2)=CC=C1COC1=CC=CC=C1 XJMKGRLNFHPTBO-UHFFFAOYSA-N 0.000 claims 1
- UALIZTYCYZRKIK-UHFFFAOYSA-N methyl 3-[3-[2-[2-[(3-methoxybenzoyl)amino]ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanoylsulfamoyl]benzoate Chemical compound COC(=O)C1=CC=CC(S(=O)(=O)NC(=O)CCC=2C(=CC(CN3N=CC=C3)=CC=2)OCCNC(=O)C=2C=C(OC)C=CC=2)=C1 UALIZTYCYZRKIK-UHFFFAOYSA-N 0.000 claims 1
- ZEVIYZJJWRWPFH-UHFFFAOYSA-N methyl n-[4-[3-[(3,4-difluorophenyl)sulfonylamino]-3-oxopropyl]-3-[(3-methyl-1-phenylbutyl)carbamoyl]phenyl]carbamate Chemical compound C=1C=CC=CC=1C(CC(C)C)NC(=O)C1=CC(NC(=O)OC)=CC=C1CCC(=O)NS(=O)(=O)C1=CC=C(F)C(F)=C1 ZEVIYZJJWRWPFH-UHFFFAOYSA-N 0.000 claims 1
- DNCONSNSYVSDIU-UHFFFAOYSA-N n-(1-methylimidazol-2-yl)sulfonyl-3-[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound CN1C=CN=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CN1N=CC=C1 DNCONSNSYVSDIU-UHFFFAOYSA-N 0.000 claims 1
- HWYVYZUZQZLQCZ-UHFFFAOYSA-N n-(1-methylpyrrol-2-yl)sulfonyl-3-[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound CN1C=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CN1N=CC=C1 HWYVYZUZQZLQCZ-UHFFFAOYSA-N 0.000 claims 1
- GYTQVDKJIDSQCK-UHFFFAOYSA-N n-(2,5-dimethoxyphenyl)sulfonyl-3-[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound COC1=CC=C(OC)C(S(=O)(=O)NC(=O)CCC=2C(=CC(CN3N=CC=C3)=CC=2)OCCC=2C=C3C=CC=CC3=CC=2)=C1 GYTQVDKJIDSQCK-UHFFFAOYSA-N 0.000 claims 1
- CKCWPAAEMGWHFL-UHFFFAOYSA-N n-(3,4-dichlorophenyl)sulfonyl-3-[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound C1=C(Cl)C(Cl)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CN1N=CC=C1 CKCWPAAEMGWHFL-UHFFFAOYSA-N 0.000 claims 1
- ZUJNXEJHXBQKPV-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-2-[1-(2-naphthalen-1-ylpropanoyl)indol-3-yl]acetamide Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)N(C1=CC=CC=C11)C=C1CC(=O)NS(=O)(=O)C1=CC=C(F)C(F)=C1 ZUJNXEJHXBQKPV-UHFFFAOYSA-N 0.000 claims 1
- LZSSLWLFWCMPDN-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-2-[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenoxy]acetamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)COC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CN1N=CC=C1 LZSSLWLFWCMPDN-UHFFFAOYSA-N 0.000 claims 1
- KEBIAYTYCJGQLN-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-2-[2-(3-methyl-1-phenylbutyl)-3-oxo-5-(phenoxymethyl)-1h-isoindol-1-yl]acetamide Chemical compound C=1C=CC=CC=1C(CC(C)C)N(C(C1=CC(COC=2C=CC=CC=2)=CC=C11)=O)C1CC(=O)NS(=O)(=O)C1=CC=C(F)C(F)=C1 KEBIAYTYCJGQLN-UHFFFAOYSA-N 0.000 claims 1
- NEKWPIGRIZWAKI-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-2-[2-(3-naphthalen-2-ylpropyl)-4-(pyrazol-1-ylmethyl)phenoxy]acetamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)COC(C(=C1)CCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CN1N=CC=C1 NEKWPIGRIZWAKI-UHFFFAOYSA-N 0.000 claims 1
- PFCYNBCLIYCNAL-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-2-[2-methyl-1-(2-naphthalen-1-ylpropanoyl)indol-3-yl]acetamide Chemical compound C=1C=CC2=CC=CC=C2C=1C(C)C(=O)N(C1=CC=CC=C11)C(C)=C1CC(=O)NS(=O)(=O)C1=CC=C(F)C(F)=C1 PFCYNBCLIYCNAL-UHFFFAOYSA-N 0.000 claims 1
- PDVAORJKFGYUJG-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-2-[[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]methoxy]acetamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)COCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CN1N=CC=C1 PDVAORJKFGYUJG-UHFFFAOYSA-N 0.000 claims 1
- WJGUIBZLIYTUOU-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[2-(2-indazol-1-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCN2C3=CC=CC=C3C=N2)=CC=C1CN1N=CC=C1 WJGUIBZLIYTUOU-UHFFFAOYSA-N 0.000 claims 1
- YADOWAFJFUKKAB-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]prop-2-ynamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)C#CC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CN1N=CC=C1 YADOWAFJFUKKAB-UHFFFAOYSA-N 0.000 claims 1
- CBYYDCDFSINGQQ-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CN1N=CC=C1 CBYYDCDFSINGQQ-UHFFFAOYSA-N 0.000 claims 1
- LIBMRMOJDPGDBB-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[2-(2-naphthalen-2-ylethoxy)-4-(pyridin-3-yloxymethyl)phenyl]propanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1COC1=CC=CN=C1 LIBMRMOJDPGDBB-UHFFFAOYSA-N 0.000 claims 1
- VZNJBDXARQQSRL-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[2-(2-naphthalen-2-ylethoxy)-4-[(1,3-thiazol-2-ylamino)methyl]phenyl]propanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CNC1=NC=CS1 VZNJBDXARQQSRL-UHFFFAOYSA-N 0.000 claims 1
- LJDQDNPWSXPVNF-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[2-(2-naphthalen-2-ylethoxy)-4-phenoxyphenyl]propanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1OC1=CC=CC=C1 LJDQDNPWSXPVNF-UHFFFAOYSA-N 0.000 claims 1
- PMEAVZAPKBDLPB-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[2-(2-naphthalen-2-ylethoxy)-4-pyridin-2-yloxyphenyl]propanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1OC1=CC=CC=N1 PMEAVZAPKBDLPB-UHFFFAOYSA-N 0.000 claims 1
- ODDJYDFHXSKXHR-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[2-(2-phenylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2C=CC=CC=2)=CC=C1CN1N=CC=C1 ODDJYDFHXSKXHR-UHFFFAOYSA-N 0.000 claims 1
- BHHMSDZFLVGHOC-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[2-(2-piperidin-1-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCN2CCCCC2)=CC=C1CN1N=CC=C1 BHHMSDZFLVGHOC-UHFFFAOYSA-N 0.000 claims 1
- HTTARIFKBKGCIT-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[2-(3-phenylpropoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCCC=2C=CC=CC=2)=CC=C1CN1N=CC=C1 HTTARIFKBKGCIT-UHFFFAOYSA-N 0.000 claims 1
- RETSDXMRXQCPII-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[2-(4-phenylbutoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCCCC=2C=CC=CC=2)=CC=C1CN1N=CC=C1 RETSDXMRXQCPII-UHFFFAOYSA-N 0.000 claims 1
- GMNQRRGDUBCQKA-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[2-(5-phenylpent-1-enyl)-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)C=CCCCC=2C=CC=CC=2)=CC=C1CN1N=CC=C1 GMNQRRGDUBCQKA-UHFFFAOYSA-N 0.000 claims 1
- CQQSZUVBPXJVDP-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[2-(5-phenylpent-1-ynyl)-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)C#CCCCC=2C=CC=CC=2)=CC=C1CN1N=CC=C1 CQQSZUVBPXJVDP-UHFFFAOYSA-N 0.000 claims 1
- BJBVMMRJTSYDHC-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[2-(5-phenylpentoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCCCCC=2C=CC=CC=2)=CC=C1CN1N=CC=C1 BJBVMMRJTSYDHC-UHFFFAOYSA-N 0.000 claims 1
- FIAAQMNALYKJCD-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[2-[(2-naphthalen-1-ylacetyl)amino]-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)NC(=O)CC=2C3=CC=CC=C3C=CC=2)=CC=C1CN1N=CC=C1 FIAAQMNALYKJCD-UHFFFAOYSA-N 0.000 claims 1
- OJXABRLHRYWBFI-XBXARRHUSA-N n-(3,4-difluorophenyl)sulfonyl-3-[2-[(e)-3-phenylprop-2-enoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OC\C=C\C=2C=CC=CC=2)=CC=C1CN1N=CC=C1 OJXABRLHRYWBFI-XBXARRHUSA-N 0.000 claims 1
- ADTIESUREHALJE-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[2-[2-(2-methylbenzimidazol-1-yl)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound CC1=NC2=CC=CC=C2N1CCOC(C(=CC=1)CCC(=O)NS(=O)(=O)C=2C=C(F)C(F)=CC=2)=CC=1CN1C=CC=N1 ADTIESUREHALJE-UHFFFAOYSA-N 0.000 claims 1
- VVWKJHLPHXOIBG-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[2-[2-(3-morpholin-4-ylphenyl)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2C=C(C=CC=2)N2CCOCC2)=CC=C1CN1N=CC=C1 VVWKJHLPHXOIBG-UHFFFAOYSA-N 0.000 claims 1
- SNSLYECQIYTCAI-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[2-[2-(4-phenylpiperazin-1-yl)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCN2CCN(CC2)C=2C=CC=CC=2)=CC=C1CN1N=CC=C1 SNSLYECQIYTCAI-UHFFFAOYSA-N 0.000 claims 1
- FXKCOKZUXTZEOB-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[2-[2-(4-phenylpiperidin-1-yl)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCN2CCC(CC2)C=2C=CC=CC=2)=CC=C1CN1N=CC=C1 FXKCOKZUXTZEOB-UHFFFAOYSA-N 0.000 claims 1
- AZONNLPDNHJLHV-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[2-[2-(n-ethylanilino)ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound C=1C=CC=CC=1N(CC)CCOC(C(=CC=1)CCC(=O)NS(=O)(=O)C=2C=C(F)C(F)=CC=2)=CC=1CN1C=CC=N1 AZONNLPDNHJLHV-UHFFFAOYSA-N 0.000 claims 1
- YFPIAMZGBCUAJN-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[2-[2-(naphthalen-1-ylamino)-2-oxoethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCC(=O)NC=2C3=CC=CC=C3C=CC=2)=CC=C1CN1N=CC=C1 YFPIAMZGBCUAJN-UHFFFAOYSA-N 0.000 claims 1
- WHVSWOAEUTZCFO-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[2-[2-[n-(2-hydroxyethyl)anilino]ethoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound C=1C=CC=CC=1N(CCO)CCOC(C(=CC=1)CCC(=O)NS(=O)(=O)C=2C=C(F)C(F)=CC=2)=CC=1CN1C=CC=N1 WHVSWOAEUTZCFO-UHFFFAOYSA-N 0.000 claims 1
- MLHXLZGVPVGWDK-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[2-[3-(n-methylanilino)propoxy]-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound C=1C=CC=CC=1N(C)CCCOC(C(=CC=1)CCC(=O)NS(=O)(=O)C=2C=C(F)C(F)=CC=2)=CC=1CN1C=CC=N1 MLHXLZGVPVGWDK-UHFFFAOYSA-N 0.000 claims 1
- ZPOOFMIHJADIMD-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[3-(3-naphthalen-1-ylpropoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C=C1OCCCC=2C3=CC=CC=C3C=CC=2)=CC=C1CN1N=CC=C1 ZPOOFMIHJADIMD-UHFFFAOYSA-N 0.000 claims 1
- LCTAXHZXBXKVPI-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[3-(3-naphthalen-2-ylpropoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C=C1OCCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CN1N=CC=C1 LCTAXHZXBXKVPI-UHFFFAOYSA-N 0.000 claims 1
- SOFSGTIMPIVFSC-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[3-(3-phenylpropoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C=C1OCCCC=2C=CC=CC=2)=CC=C1CN1N=CC=C1 SOFSGTIMPIVFSC-UHFFFAOYSA-N 0.000 claims 1
- GFBHENTZDORTBJ-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[4-(2-hydroxypropan-2-yl)-2-(2-naphthalen-2-ylethoxy)phenyl]propanamide Chemical compound C=1C=C2C=CC=CC2=CC=1CCOC1=CC(C(C)(O)C)=CC=C1CCC(=O)NS(=O)(=O)C1=CC=C(F)C(F)=C1 GFBHENTZDORTBJ-UHFFFAOYSA-N 0.000 claims 1
- LNUGXQFESYUEMO-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[4-(hydroxymethyl)-2-(2-naphthalen-2-ylethoxy)phenyl]propanamide Chemical compound C=1C=C2C=CC=CC2=CC=1CCOC1=CC(CO)=CC=C1CCC(=O)NS(=O)(=O)C1=CC=C(F)C(F)=C1 LNUGXQFESYUEMO-UHFFFAOYSA-N 0.000 claims 1
- DQXHOEHLDULSJW-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[4-(methanesulfonamido)-2-(2-naphthalen-2-ylethoxy)phenyl]propanamide Chemical compound C=1C=C2C=CC=CC2=CC=1CCOC1=CC(NS(=O)(=O)C)=CC=C1CCC(=O)NS(=O)(=O)C1=CC=C(F)C(F)=C1 DQXHOEHLDULSJW-UHFFFAOYSA-N 0.000 claims 1
- IKFLJLTYLBSWLY-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[4-(pyrazol-1-ylmethyl)-2-(2-thiophen-2-ylethoxy)phenyl]propanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2SC=CC=2)=CC=C1CN1N=CC=C1 IKFLJLTYLBSWLY-UHFFFAOYSA-N 0.000 claims 1
- DBYBEFFSHLLDIA-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[4-(pyrazol-1-ylmethyl)-2-(2-thiophen-3-ylethoxy)phenyl]propanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC2=CSC=C2)=CC=C1CN1N=CC=C1 DBYBEFFSHLLDIA-UHFFFAOYSA-N 0.000 claims 1
- YUGBTEIHGCYTPT-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[4-[(4-methylpiperazin-1-yl)methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]propanamide Chemical compound C1CN(C)CCN1CC(C=C1OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CCC(=O)NS(=O)(=O)C1=CC=C(F)C(F)=C1 YUGBTEIHGCYTPT-UHFFFAOYSA-N 0.000 claims 1
- XFEQJTJHYVKTOT-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-3-[4-[(dimethylamino)methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]propanamide Chemical compound C=1C=C2C=CC=CC2=CC=1CCOC1=CC(CN(C)C)=CC=C1CCC(=O)NS(=O)(=O)C1=CC=C(F)C(F)=C1 XFEQJTJHYVKTOT-UHFFFAOYSA-N 0.000 claims 1
- SSVWYTOFARLINN-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-4-[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]butanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CN1N=CC=C1 SSVWYTOFARLINN-UHFFFAOYSA-N 0.000 claims 1
- ILQILKMEFXJWLG-UHFFFAOYSA-N n-(3,4-difluorophenyl)sulfonyl-5-[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]pentanamide Chemical compound C1=C(F)C(F)=CC=C1S(=O)(=O)NC(=O)CCCCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CN1N=CC=C1 ILQILKMEFXJWLG-UHFFFAOYSA-N 0.000 claims 1
- PFIDKAWCTPWFID-UHFFFAOYSA-N n-(3-chloro-4-fluorophenyl)sulfonyl-3-[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound C1=C(Cl)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CN1N=CC=C1 PFIDKAWCTPWFID-UHFFFAOYSA-N 0.000 claims 1
- VKJLQHZKRQCYQG-UHFFFAOYSA-N n-(3-chloro-4-fluorophenyl)sulfonyl-3-[4-[(3-cyanophenoxy)methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]propanamide Chemical compound C1=C(Cl)C(F)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1COC1=CC=CC(C#N)=C1 VKJLQHZKRQCYQG-UHFFFAOYSA-N 0.000 claims 1
- NHYQFTFAZLIILG-UHFFFAOYSA-N n-(3-chloro-4-methylphenyl)sulfonyl-3-[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound C1=C(Cl)C(C)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CN1N=CC=C1 NHYQFTFAZLIILG-UHFFFAOYSA-N 0.000 claims 1
- HIXLHLHTCYKIKP-UHFFFAOYSA-N n-(3-chloro-4-methylphenyl)sulfonyl-3-[4-[(3-cyanophenoxy)methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]propanamide Chemical compound C1=C(Cl)C(C)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1COC1=CC=CC(C#N)=C1 HIXLHLHTCYKIKP-UHFFFAOYSA-N 0.000 claims 1
- OMCNULAVHAQSBD-UHFFFAOYSA-N n-(3-cyanophenyl)sulfonyl-3-[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound C=1C=CC(C#N)=CC=1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CN1C=CC=N1 OMCNULAVHAQSBD-UHFFFAOYSA-N 0.000 claims 1
- VXDYGDOOQCIHFH-UHFFFAOYSA-N n-(4-methoxyphenyl)sulfonyl-3-[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CN1N=CC=C1 VXDYGDOOQCIHFH-UHFFFAOYSA-N 0.000 claims 1
- MHOWRUXMWCCMLK-UHFFFAOYSA-N n-(5-bromo-2-methoxyphenyl)sulfonyl-3-[2-(naphthalen-2-ylmethyl)-4-(phenoxymethyl)phenyl]propanamide Chemical compound COC1=CC=C(Br)C=C1S(=O)(=O)NC(=O)CCC(C(=C1)CC=2C=C3C=CC=CC3=CC=2)=CC=C1COC1=CC=CC=C1 MHOWRUXMWCCMLK-UHFFFAOYSA-N 0.000 claims 1
- WAJGCUPVSMBCII-UHFFFAOYSA-N n-(5-bromo-2-methoxyphenyl)sulfonyl-3-[2-(naphthalen-2-ylmethyl)-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound COC1=CC=C(Br)C=C1S(=O)(=O)NC(=O)CCC(C(=C1)CC=2C=C3C=CC=CC3=CC=2)=CC=C1CN1N=CC=C1 WAJGCUPVSMBCII-UHFFFAOYSA-N 0.000 claims 1
- UOWFBSNAOFFEHS-UHFFFAOYSA-N n-(5-methylfuran-2-yl)sulfonyl-3-[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound O1C(C)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CN1N=CC=C1 UOWFBSNAOFFEHS-UHFFFAOYSA-N 0.000 claims 1
- YYIPEDQUQNLWRK-UHFFFAOYSA-N n-(benzenesulfonyl)-2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)benzamide Chemical compound C=1C=C(CN2N=CC=C2)C=C(OCCC=2C=C3C=CC=CC3=CC=2)C=1C(=O)NS(=O)(=O)C1=CC=CC=C1 YYIPEDQUQNLWRK-UHFFFAOYSA-N 0.000 claims 1
- BGVGZZBUGHDVQK-UHFFFAOYSA-N n-(benzenesulfonyl)-2-[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]acetamide Chemical compound C=1C=CC=CC=1S(=O)(=O)NC(=O)CC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CN1C=CC=N1 BGVGZZBUGHDVQK-UHFFFAOYSA-N 0.000 claims 1
- UNMZXPVGFPCIMV-UHFFFAOYSA-N n-(benzenesulfonyl)-3-[2-(2-naphthalen-2-ylethoxy)-4-(phenoxymethyl)phenyl]propanamide Chemical compound C=1C=CC=CC=1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1COC1=CC=CC=C1 UNMZXPVGFPCIMV-UHFFFAOYSA-N 0.000 claims 1
- QUSZOZYYCJJSKS-UHFFFAOYSA-N n-(benzenesulfonyl)-3-[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound C=1C=CC=CC=1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CN1C=CC=N1 QUSZOZYYCJJSKS-UHFFFAOYSA-N 0.000 claims 1
- HNUMATOASNLYKC-UHFFFAOYSA-N n-(benzenesulfonyl)-3-[2-(2-phenylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound C=1C=CC=CC=1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2C=CC=CC=2)=CC=C1CN1C=CC=N1 HNUMATOASNLYKC-UHFFFAOYSA-N 0.000 claims 1
- PQEPRWUZLQUFPI-UHFFFAOYSA-N n-(benzenesulfonyl)-3-[4-(phenoxymethyl)-2-(2-phenylethoxy)phenyl]propanamide Chemical compound C=1C=CC=CC=1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2C=CC=CC=2)=CC=C1COC1=CC=CC=C1 PQEPRWUZLQUFPI-UHFFFAOYSA-N 0.000 claims 1
- YTYCXCNNPTVRSU-UHFFFAOYSA-N n-(benzenesulfonyl)-4-[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]butanamide Chemical compound C=1C=CC=CC=1S(=O)(=O)NC(=O)CCCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CN1C=CC=N1 YTYCXCNNPTVRSU-UHFFFAOYSA-N 0.000 claims 1
- HIOVZUOYYJCLAU-UHFFFAOYSA-N n-(furan-3-ylsulfonyl)-3-[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound C1=COC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CN1C=CC=N1 HIOVZUOYYJCLAU-UHFFFAOYSA-N 0.000 claims 1
- NDYDWWZLZXOBGM-UHFFFAOYSA-N n-[(3,5-dimethyl-1,2-oxazol-4-yl)sulfonyl]-3-[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound CC1=NOC(C)=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CN1N=CC=C1 NDYDWWZLZXOBGM-UHFFFAOYSA-N 0.000 claims 1
- WYCCPZIRVBEAGS-UHFFFAOYSA-N n-[(4-chloro-2,1,3-benzoxadiazol-7-yl)sulfonyl]-3-[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound C12=NON=C2C(Cl)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1CN1C=CC=N1 WYCCPZIRVBEAGS-UHFFFAOYSA-N 0.000 claims 1
- BJFSXWGXDARYOV-UHFFFAOYSA-N n-[(4-chloro-2,1,3-benzoxadiazol-7-yl)sulfonyl]-3-[4-[(3-cyanophenoxy)methyl]-2-(2-naphthalen-2-ylethoxy)phenyl]propanamide Chemical compound C12=NON=C2C(Cl)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)OCCC=2C=C3C=CC=CC3=CC=2)=CC=C1COC1=CC=CC(C#N)=C1 BJFSXWGXDARYOV-UHFFFAOYSA-N 0.000 claims 1
- YLMOCMGDRVJRLP-UHFFFAOYSA-N n-[(4-methyl-1,3-thiazol-2-yl)sulfonyl]-3-[2-(2-naphthalen-2-ylethoxy)-4-(pyrazol-1-ylmethyl)phenyl]propanamide Chemical compound CC1=CSC(S(=O)(=O)NC(=O)CCC=2C(=CC(CN3N=CC=C3)=CC=2)OCCC=2C=C3C=CC=CC3=CC=2)=N1 YLMOCMGDRVJRLP-UHFFFAOYSA-N 0.000 claims 1
- HMENWVKIVXGOIT-UHFFFAOYSA-N n-[1-(4-fluorophenyl)-3-methylbutyl]-2-(3-formamidopropyl)-5-(phenoxymethyl)benzamide Chemical compound C=1C=C(F)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCCNC=O)=CC=1COC1=CC=CC=C1 HMENWVKIVXGOIT-UHFFFAOYSA-N 0.000 claims 1
- OLQMPJIGPXABFC-UHFFFAOYSA-N n-[1-(4-fluorophenyl)-3-methylbutyl]-2-[3-(furan-3-ylsulfonylamino)-3-oxopropyl]-5-(phenoxymethyl)benzamide Chemical compound C=1C=C(F)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(=O)NS(=O)(=O)C2=COC=C2)=CC=1COC1=CC=CC=C1 OLQMPJIGPXABFC-UHFFFAOYSA-N 0.000 claims 1
- MSHUWUNMNACEJY-UHFFFAOYSA-N n-[1-(4-fluorophenyl)-3-methylbutyl]-2-[3-(hydroxyamino)-3-oxopropyl]-5-(phenoxymethyl)benzamide Chemical compound C=1C=C(F)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(=O)NO)=CC=1COC1=CC=CC=C1 MSHUWUNMNACEJY-UHFFFAOYSA-N 0.000 claims 1
- RCLZQTPKCVEKQY-UHFFFAOYSA-N n-[1-(4-fluorophenyl)-3-methylbutyl]-2-[3-(methanesulfonamido)propyl]-5-(phenoxymethyl)benzamide Chemical compound C=1C=C(F)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCCNS(C)(=O)=O)=CC=1COC1=CC=CC=C1 RCLZQTPKCVEKQY-UHFFFAOYSA-N 0.000 claims 1
- AFXXYAYOCKIHLL-UHFFFAOYSA-N n-[1-(4-fluorophenyl)-3-methylbutyl]-2-[3-(methylamino)-3-oxopropyl]-5-(phenoxymethyl)benzamide Chemical compound C1=C(C(=O)NC(CC(C)C)C=2C=CC(F)=CC=2)C(CCC(=O)NC)=CC=C1COC1=CC=CC=C1 AFXXYAYOCKIHLL-UHFFFAOYSA-N 0.000 claims 1
- ORSVHIYEKVDOPY-UHFFFAOYSA-N n-[1-(4-fluorophenyl)-3-methylbutyl]-2-[3-(naphthalen-1-ylsulfonylamino)-3-oxopropyl]-5-(phenoxymethyl)benzamide Chemical compound C=1C=C(F)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(=O)NS(=O)(=O)C=2C3=CC=CC=C3C=CC=2)=CC=1COC1=CC=CC=C1 ORSVHIYEKVDOPY-UHFFFAOYSA-N 0.000 claims 1
- GSFIIIMEKLDQBT-UHFFFAOYSA-N n-[1-(4-fluorophenyl)-3-methylbutyl]-2-[3-(naphthalen-2-ylsulfonylamino)-3-oxopropyl]-5-(phenoxymethyl)benzamide Chemical compound C=1C=C(F)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(=O)NS(=O)(=O)C=2C=C3C=CC=CC3=CC=2)=CC=1COC1=CC=CC=C1 GSFIIIMEKLDQBT-UHFFFAOYSA-N 0.000 claims 1
- FUPMXSSPDSZHDB-UHFFFAOYSA-N n-[1-(4-fluorophenyl)-3-methylbutyl]-2-[3-[(1-methylpyrrol-2-yl)sulfonylamino]-3-oxopropyl]-5-(phenoxymethyl)benzamide Chemical compound C=1C=C(F)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(=O)NS(=O)(=O)C=2N(C=CC=2)C)=CC=1COC1=CC=CC=C1 FUPMXSSPDSZHDB-UHFFFAOYSA-N 0.000 claims 1
- OGAVWWSSPREQSD-UHFFFAOYSA-N n-[1-(4-fluorophenyl)-3-methylbutyl]-2-[3-[(2-fluorophenyl)sulfonylamino]-3-oxopropyl]-5-(phenoxymethyl)benzamide Chemical compound C=1C=C(F)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(=O)NS(=O)(=O)C=2C(=CC=CC=2)F)=CC=1COC1=CC=CC=C1 OGAVWWSSPREQSD-UHFFFAOYSA-N 0.000 claims 1
- YVSZRTBEZWOQQK-UHFFFAOYSA-N n-[1-(4-fluorophenyl)-3-methylbutyl]-2-[3-[(3-methoxyphenyl)sulfonylamino]-3-oxopropyl]-5-(phenoxymethyl)benzamide Chemical compound COC1=CC=CC(S(=O)(=O)NC(=O)CCC=2C(=CC(COC=3C=CC=CC=3)=CC=2)C(=O)NC(CC(C)C)C=2C=CC(F)=CC=2)=C1 YVSZRTBEZWOQQK-UHFFFAOYSA-N 0.000 claims 1
- XLWLIHSZXCHDCR-UHFFFAOYSA-N n-[1-(4-fluorophenyl)-3-methylbutyl]-2-[3-[(3-methylphenyl)sulfonylamino]-3-oxopropyl]-5-(phenoxymethyl)benzamide Chemical compound C=1C=C(F)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(=O)NS(=O)(=O)C=2C=C(C)C=CC=2)=CC=1COC1=CC=CC=C1 XLWLIHSZXCHDCR-UHFFFAOYSA-N 0.000 claims 1
- IISLAORKLYYCLJ-UHFFFAOYSA-N n-[1-(4-fluorophenyl)-3-methylbutyl]-2-[3-[(4-fluorophenyl)sulfonylamino]-3-oxopropyl]-5-(phenoxymethyl)benzamide Chemical compound C=1C=C(F)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(=O)NS(=O)(=O)C=2C=CC(F)=CC=2)=CC=1COC1=CC=CC=C1 IISLAORKLYYCLJ-UHFFFAOYSA-N 0.000 claims 1
- DCFMHDUEPKASJB-UHFFFAOYSA-N n-[1-(4-fluorophenyl)-3-methylbutyl]-2-[3-[(4-methoxyphenyl)sulfonylamino]-3-oxopropyl]-5-(phenoxymethyl)benzamide Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)NC(=O)CCC(C(=C1)C(=O)NC(CC(C)C)C=2C=CC(F)=CC=2)=CC=C1COC1=CC=CC=C1 DCFMHDUEPKASJB-UHFFFAOYSA-N 0.000 claims 1
- IQTSGLLILDNICL-UHFFFAOYSA-N n-[1-(4-fluorophenyl)-3-methylbutyl]-2-[3-[(4-methylsulfonylphenyl)sulfonylamino]-3-oxopropyl]-5-(phenoxymethyl)benzamide Chemical compound C=1C=C(F)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(=O)NS(=O)(=O)C=2C=CC(=CC=2)S(C)(=O)=O)=CC=1COC1=CC=CC=C1 IQTSGLLILDNICL-UHFFFAOYSA-N 0.000 claims 1
- DNBSBCZFPCQMPW-UHFFFAOYSA-N n-[1-(4-fluorophenyl)-3-methylbutyl]-2-[3-[(5-methylfuran-2-yl)sulfonylamino]-3-oxopropyl]-5-(phenoxymethyl)benzamide Chemical compound C=1C=C(F)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(=O)NS(=O)(=O)C=2OC(C)=CC=2)=CC=1COC1=CC=CC=C1 DNBSBCZFPCQMPW-UHFFFAOYSA-N 0.000 claims 1
- FJIPBEVZSBUCSM-UHFFFAOYSA-N n-[1-(4-fluorophenyl)-3-methylbutyl]-2-[3-[[3-(5-methyl-3-oxo-1h-pyrazol-2-yl)phenyl]sulfonylamino]-3-oxopropyl]-5-(phenoxymethyl)benzamide Chemical compound C=1C=C(F)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(=O)NS(=O)(=O)C=2C=C(C=CC=2)N2C(C=C(C)N2)=O)=CC=1COC1=CC=CC=C1 FJIPBEVZSBUCSM-UHFFFAOYSA-N 0.000 claims 1
- ALEDQCRBXZMARM-UHFFFAOYSA-N n-[1-(4-fluorophenyl)-3-methylbutyl]-2-[3-oxo-3-(2h-tetrazol-5-ylamino)propyl]-5-(phenoxymethyl)benzamide Chemical compound C=1C=C(F)C=CC=1C(CC(C)C)NC(=O)C(C(=CC=1)CCC(=O)NC=2NN=NN=2)=CC=1COC1=CC=CC=C1 ALEDQCRBXZMARM-UHFFFAOYSA-N 0.000 claims 1
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-
2002
- 2002-08-08 JP JP2003521183A patent/JP4529119B2/ja not_active Expired - Fee Related
- 2002-08-08 BR BR0211810-6A patent/BR0211810A/pt not_active IP Right Cessation
- 2002-08-08 PL PL02368129A patent/PL368129A1/xx not_active Application Discontinuation
- 2002-08-08 IL IL16025302A patent/IL160253A0/xx unknown
- 2002-08-08 NZ NZ531153A patent/NZ531153A/en unknown
- 2002-08-08 CN CNA2008100022607A patent/CN101284773A/zh active Pending
- 2002-08-08 EP EP02755874A patent/EP1431267A4/en not_active Withdrawn
- 2002-08-08 HU HU0401963A patent/HUP0401963A3/hu unknown
- 2002-08-08 US US10/486,220 patent/US7491748B2/en not_active Expired - Fee Related
- 2002-08-08 WO PCT/JP2002/008120 patent/WO2003016254A1/ja active IP Right Grant
- 2002-08-08 CN CNA028173767A patent/CN1551866A/zh active Pending
- 2002-08-08 MX MXPA04001253A patent/MXPA04001253A/es not_active Application Discontinuation
- 2002-08-08 KR KR10-2004-7001851A patent/KR20040022238A/ko not_active Application Discontinuation
- 2002-08-08 RU RU2004106623/04A patent/RU2315746C2/ru not_active IP Right Cessation
- 2002-08-08 NZ NZ541950A patent/NZ541950A/en unknown
- 2002-08-08 CA CA002457468A patent/CA2457468A1/en not_active Abandoned
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2004
- 2004-02-05 ZA ZA200400973A patent/ZA200400973B/en unknown
- 2004-02-06 NO NO20040564A patent/NO20040564L/no not_active Application Discontinuation
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2008
- 2008-10-27 US US12/259,012 patent/US7786161B2/en not_active Expired - Fee Related
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PL368129A1 (en) | 2005-03-21 |
US7786161B2 (en) | 2010-08-31 |
US7491748B2 (en) | 2009-02-17 |
HUP0401963A3 (en) | 2006-01-30 |
US20090318703A1 (en) | 2009-12-24 |
JPWO2003016254A1 (ja) | 2004-12-02 |
CA2457468A1 (en) | 2003-02-27 |
KR20040022238A (ko) | 2004-03-11 |
JP4529119B2 (ja) | 2010-08-25 |
WO2003016254A1 (fr) | 2003-02-27 |
EP1431267A4 (en) | 2004-12-22 |
BR0211810A (pt) | 2004-08-24 |
NZ541950A (en) | 2007-02-23 |
HUP0401963A2 (hu) | 2005-01-28 |
CN1551866A (zh) | 2004-12-01 |
IL160253A0 (en) | 2004-07-25 |
RU2004106623A (ru) | 2005-07-20 |
CN101284773A (zh) | 2008-10-15 |
US20060258728A1 (en) | 2006-11-16 |
EP1431267A1 (en) | 2004-06-23 |
RU2315746C2 (ru) | 2008-01-27 |
MXPA04001253A (es) | 2004-06-03 |
NO20040564L (no) | 2004-05-10 |
NZ531153A (en) | 2005-10-28 |
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