MXPA04001253A - Derivados de acidos carboxilicos y agente farmaceutico que comprende los mismos como ingrediente activo. - Google Patents

Derivados de acidos carboxilicos y agente farmaceutico que comprende los mismos como ingrediente activo.

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Publication number
MXPA04001253A
MXPA04001253A MXPA04001253A MXPA04001253A MXPA04001253A MX PA04001253 A MXPA04001253 A MX PA04001253A MX PA04001253 A MXPA04001253 A MX PA04001253A MX PA04001253 A MXPA04001253 A MX PA04001253A MX PA04001253 A MXPA04001253 A MX PA04001253A
Authority
MX
Mexico
Prior art keywords
compounds
alkylene
carboxylic acid
drugs
active ingredient
Prior art date
Application number
MXPA04001253A
Other languages
English (en)
Inventor
Tani Kousuke
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Publication of MXPA04001253A publication Critical patent/MXPA04001253A/es

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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
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Abstract

Se describe un derivado de acido carboxilico de la formula (I): (ver formula) en donde R1 es -COOH, -COOR6, etc; A es un enlace sencillo, alquileno, etc; R2 es alquilo, alcoxi, etc; B es un anillo carbociclico o un anillo heterociclico; Q es alquileno-Cyc2, etc; D es una cadena de enlace; y R3 es alquilo, un anillo carbociclico o un anillo heterociclico, o una sal no toxica del mismo. El compuesto de la formula (I) (ver formula) que se enlaza al receptor PGE2, especialmente los subtipos EP3 y/o EP4 y muestra la actividad antagonista, son utiles para la prevencion y/o tratamiento de enfermedades que inducen el dolor, comezon, urticaria, alergia, frecuencia urinaria, disturbios de orina, enfermedad de Alzheimer, cancer, dismenorrea, endometriosis, etc.
MXPA04001253A 2001-08-09 2002-08-08 Derivados de acidos carboxilicos y agente farmaceutico que comprende los mismos como ingrediente activo. MXPA04001253A (es)

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PCT/JP2002/008120 WO2003016254A1 (fr) 2001-08-09 2002-08-08 Composes derives d'acide carboxylique et medicaments comprenant ces composes comme principe actif

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