ZA200104069B - Dispersible phospholipid stabilized microparticles. - Google Patents
Dispersible phospholipid stabilized microparticles. Download PDFInfo
- Publication number
- ZA200104069B ZA200104069B ZA200104069A ZA200104069A ZA200104069B ZA 200104069 B ZA200104069 B ZA 200104069B ZA 200104069 A ZA200104069 A ZA 200104069A ZA 200104069 A ZA200104069 A ZA 200104069A ZA 200104069 B ZA200104069 B ZA 200104069B
- Authority
- ZA
- South Africa
- Prior art keywords
- dosage form
- rapidly dispersing
- solid dosage
- dispersing solid
- water insoluble
- Prior art date
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- 150000003904 phospholipids Chemical class 0.000 title claims description 19
- 239000011859 microparticle Substances 0.000 title description 7
- 239000002245 particle Substances 0.000 claims description 35
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- 239000007909 solid dosage form Substances 0.000 claims description 15
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- 239000011347 resin Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- CBHOWTTXCQAOID-UHFFFAOYSA-L sodium ethane formaldehyde mercury(2+) molecular iodine 2-sulfidobenzoate Chemical compound [Na+].[Hg++].C[CH2-].II.C=O.[O-]C(=O)c1ccccc1[S-] CBHOWTTXCQAOID-UHFFFAOYSA-L 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000008347 soybean phospholipid Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 229940012831 stearyl alcohol Drugs 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 229940029614 triethanolamine stearate Drugs 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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US10920298P | 1998-11-20 | 1998-11-20 |
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ZA200104069A ZA200104069B (en) | 1998-11-20 | 2001-05-18 | Dispersible phospholipid stabilized microparticles. |
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EP (1) | EP1133281A1 (no) |
JP (2) | JP4809533B2 (no) |
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CN (1) | CN1287769C (no) |
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BR (1) | BR9915738A (no) |
CA (1) | CA2349203C (no) |
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HK (1) | HK1042856B (no) |
HU (1) | HUP0105089A3 (no) |
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NZ (1) | NZ511792A (no) |
PL (1) | PL201578B1 (no) |
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UA (1) | UA80652C2 (no) |
WO (1) | WO2000030616A1 (no) |
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- 1999-11-19 NZ NZ511792A patent/NZ511792A/en not_active IP Right Cessation
- 1999-11-19 PL PL348868A patent/PL201578B1/pl unknown
- 1999-11-19 BR BR9915738-1A patent/BR9915738A/pt not_active Application Discontinuation
- 1999-11-19 EP EP99960498A patent/EP1133281A1/en not_active Withdrawn
- 1999-11-19 EE EEP200100269A patent/EE05190B1/xx not_active IP Right Cessation
- 1999-11-19 HU HU0105089A patent/HUP0105089A3/hu not_active Application Discontinuation
- 1999-11-19 RU RU2001116719/15A patent/RU2233654C2/ru not_active IP Right Cessation
- 1999-11-19 WO PCT/US1999/027436 patent/WO2000030616A1/en active IP Right Grant
- 1999-11-19 AU AU17375/00A patent/AU767154B2/en not_active Ceased
- 1999-11-19 US US09/443,863 patent/US7939105B2/en not_active Expired - Lifetime
- 1999-11-19 CZ CZ20011739A patent/CZ20011739A3/cs unknown
- 1999-11-19 SK SK685-2001A patent/SK288117B6/sk not_active IP Right Cessation
- 1999-11-19 IL IL14319799A patent/IL143197A0/xx unknown
- 1999-11-19 KR KR1020017006364A patent/KR20010073232A/ko not_active Application Discontinuation
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- 1999-11-19 CN CNB998156450A patent/CN1287769C/zh not_active Expired - Fee Related
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- 2001-05-18 ZA ZA200104069A patent/ZA200104069B/en unknown
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2003
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