UY27243A1 - Combinaciones inmunoterapéuticas para el tratamiento de tumores que sobre-expresan gangliósidos - Google Patents

Combinaciones inmunoterapéuticas para el tratamiento de tumores que sobre-expresan gangliósidos

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Publication number
UY27243A1
UY27243A1 UY27243A UY27243A UY27243A1 UY 27243 A1 UY27243 A1 UY 27243A1 UY 27243 A UY27243 A UY 27243A UY 27243 A UY27243 A UY 27243A UY 27243 A1 UY27243 A1 UY 27243A1
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UY
Uruguay
Prior art keywords
antibody
vaccines
active ingredient
tumors
present
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UY27243A
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English (en)
Inventor
Molina Luis E Fernandez
Vazquez Lopez Ana Maria
Perez Rodriguez Rolando
Perez Gonzalez Alexix
Carr Pcrez Adriana
Diaz Rodriguez Yildian
Fernandez Mauro A Alfonso
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Centro Inmunologia Molecular
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Publication date
Application filed by Centro Inmunologia Molecular filed Critical Centro Inmunologia Molecular
Publication of UY27243A1 publication Critical patent/UY27243A1/es

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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/739—Lipopolysaccharides
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001169—Tumor associated carbohydrates
    • A61K39/001171—Gangliosides, e.g. GM2, GD2 or GD3
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3084—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
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    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
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    • C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
    • C07K16/4266—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig against anti-tumor receptor Ig
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • C12N5/0694—Cells of blood, e.g. leukemia cells, myeloma cells
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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Abstract

La presente invención se relaciona con el campo de la inmunología y más específicamente con la inmunoterapia de cáncer, particularmente con combinaciones inmunoterapéuticas y métodos de tratamiento para impedir el crecimiento de células tumorales y/ o eliminar dichas células. Los métodos descritos en la presente invención se basan en el efecto terapéutico obtenido por la combinación de vacunas idiotípicas cuyo principio activo es un anticuerpo antigangliósido ( Ab1) o versiones recombinantes de dicho anticuerpo, con vacunas idiotípicas cuyo principio activo es un anticuerpo anti-idiotipo obtenido contra un anticuerpo antigangliósido (Ab2) o versiones recombinantes del mismo, o con vacunas cuyo principio activo es uno o más gangliósidos. Se describen combinaciones de estas vacunas que provocan un sinergismo del efecto anti-tumoral que induce cada una de las vacunas por separado, y los procedimientos referidos pueden ser aplicados a pacientes en diferentes estudios clínicos de tumores que sobre-expresan gangliósidos. La presente invención también se relaciona con la obtención de los anticuerpos recombinantes (quiméricos y humanizados) a partir del anticuerpo murino anti-gangliósido, P3(Ab1) y de su anticuerpo anti-idiotipo 1E10(Ab2).
UY27243A 2001-04-06 2002-04-05 Combinaciones inmunoterapéuticas para el tratamiento de tumores que sobre-expresan gangliósidos UY27243A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU2001008420010084A CU23007A1 (es) 2001-04-06 2001-04-06 Combinaciones inmunoterapéuticas para el tratamiencombinaciones inmunoterapéuticas para el tratamiento de tumores que sobre-expresan gangliósidos to de tumores que sobre-expresan gangliósidos

Publications (1)

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UY27243A1 true UY27243A1 (es) 2002-09-30

Family

ID=40291118

Family Applications (2)

Application Number Title Priority Date Filing Date
UY27242A UY27242A1 (es) 2001-04-06 2002-04-05 Anticuerpos recombinantes asociados a gangliosidos. su uso en el diasnostico y tratamiento de tumores
UY27243A UY27243A1 (es) 2001-04-06 2002-04-05 Combinaciones inmunoterapéuticas para el tratamiento de tumores que sobre-expresan gangliósidos

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UY27242A UY27242A1 (es) 2001-04-06 2002-04-05 Anticuerpos recombinantes asociados a gangliosidos. su uso en el diasnostico y tratamiento de tumores

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US (3) US20050069535A1 (es)
EP (3) EP1384726B1 (es)
JP (2) JP4366080B2 (es)
KR (3) KR100863509B1 (es)
CN (3) CN101054417B (es)
AR (2) AR033123A1 (es)
AT (3) ATE477279T1 (es)
AU (3) AU2002308348B2 (es)
BG (2) BG66293B1 (es)
BR (3) BR0208676B1 (es)
CA (2) CA2443372C (es)
CU (1) CU23007A1 (es)
CZ (2) CZ296276B6 (es)
DE (2) DE60223547T2 (es)
DK (2) DK1384726T3 (es)
EA (2) EA006936B1 (es)
EC (2) ECSP034788A (es)
ES (2) ES2296986T3 (es)
HK (3) HK1066818A1 (es)
HR (2) HRP20030806B1 (es)
HU (2) HU228106B1 (es)
IL (2) IL158246A0 (es)
IS (2) IS6965A (es)
MX (2) MXPA03008739A (es)
MY (3) MY145703A (es)
NO (2) NO20034437L (es)
NZ (2) NZ528598A (es)
PE (1) PE20020972A1 (es)
PL (2) PL208109B1 (es)
PT (2) PT1384726E (es)
SG (1) SG161737A1 (es)
SI (2) SI1411064T1 (es)
SK (2) SK287783B6 (es)
UA (3) UA75393C2 (es)
UY (2) UY27242A1 (es)
WO (2) WO2002081496A2 (es)
ZA (2) ZA200307585B (es)

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