CU22702A1 - Anticuerpos monoclonales anti - idiotipo, su uso en la inmunoterapia activa de tumores malignos, hibridoma que los produce y composiciones que los contienen - Google Patents
Anticuerpos monoclonales anti - idiotipo, su uso en la inmunoterapia activa de tumores malignos, hibridoma que los produce y composiciones que los contienenInfo
- Publication number
- CU22702A1 CU22702A1 CU1997119A CU1997119A CU22702A1 CU 22702 A1 CU22702 A1 CU 22702A1 CU 1997119 A CU1997119 A CU 1997119A CU 1997119 A CU1997119 A CU 1997119A CU 22702 A1 CU22702 A1 CU 22702A1
- Authority
- CU
- Cuba
- Prior art keywords
- idiotipo
- malignum
- hybridoma
- tumors
- compositions
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 210000004408 hybridoma Anatomy 0.000 title 1
- 238000009169 immunotherapy Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 241001529936 Murinae Species 0.000 abstract 2
- 230000003302 anti-idiotype Effects 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 abstract 1
- 150000002270 gangliosides Chemical class 0.000 abstract 1
- 239000002955 immunomodulating agent Substances 0.000 abstract 1
- 229940121354 immunomodulator Drugs 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
- C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
- C07K16/4266—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig against anti-tumor receptor Ig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invención se relaciona con anticuerpos monoclonales anti-idiotipos y su uso como inmunomoduladores. Más particularmente, la presente invención a un anticuerpo monoclonal murino, el cual fue desarrollado contra un anticuerpo monoclonal murino que reacciona con gangliósidos portadores de ácido siálico N-glicolilados y con los antígenos expresados en células tumorales, y su efecto inhibitorio que sobre el crecimiento tumoral.
Priority Applications (22)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU1997119A CU22702A1 (es) | 1997-10-21 | 1997-10-21 | Anticuerpos monoclonales anti - idiotipo, su uso en la inmunoterapia activa de tumores malignos, hibridoma que los produce y composiciones que los contienen |
US09/015,540 US6063379A (en) | 1993-12-09 | 1998-01-29 | Anti-idiotypic monoclonal antibodies and compositions including the anti-idiotypic monoclonal antibodies |
ARP980105212A AR017369A1 (es) | 1997-10-21 | 1998-10-20 | Anticuerpos monoclonales anti-idiotipos, su uso en la inmunoterapia activa de tumores malignos, y composiciones que los contienen |
CO98060820A CO5060487A1 (es) | 1997-10-21 | 1998-10-20 | Anticuerpos anti-idiotipos contra anticuerpos que reconocen gangliosidos portadores de acido sialico n-glicolilado y com posiciones que los contienen |
SI9830866T SI1027375T1 (sl) | 1997-10-21 | 1998-10-21 | Anti-idiotipska monoklonska protitelesa, njihova uporaba v aktivni imunoterapiji malignih tumorjev in sestavki, ki jih vsebujejo |
BR9812974-0A BR9812974A (pt) | 1997-10-21 | 1998-10-21 | Anticorpos monoclonais antiidiotìpicos, seu uso na imunoterapia ativa de tumores malignos e composições contendo os mesmos |
EA200000442A EA003366B1 (ru) | 1997-10-21 | 1998-10-21 | Антиидиотипические моноклональные антитела, их применение в активной иммунотерапии злокачественных опухолей и содержащие их композиции |
ES98952503T ES2274584T3 (es) | 1997-10-21 | 1998-10-21 | Anticuerpos monoclonales anti-idiotipicos, su uso en inmunoterapia activa de tumores malignos y composiciones que contienen los mismos. |
DE69836096T DE69836096T2 (de) | 1997-10-21 | 1998-10-21 | Anti-idiotypische monoklonale antikörper, deren verwendung zur aktiven immuntherapie bösartiger tumoren, und zusammensetzungen die diese enthalten |
AU10199/99A AU1019999A (en) | 1997-10-21 | 1998-10-21 | Anti-idiotype monoclonal antibodies, their use in active immunotherapy of malignant tumors and compositions containing them |
PCT/CU1998/000007 WO1999020656A1 (es) | 1997-10-21 | 1998-10-21 | Anticuerpos monoclonales anti-idiotipos, su uso en la inmunoterapia activa de tumores malignos, y composiciones que los contienen |
CNB988114887A CN1210309C (zh) | 1997-10-21 | 1998-10-21 | 抗独特型单克隆抗体,其在恶性肿瘤主动免疫治疗中的应用以及含有它们的组合物 |
PT98952503T PT1027375E (pt) | 1997-10-21 | 1998-10-21 | Anticorpos monoclonais anti-idiotipo, sua utilização em imunoterapia activa de tumores malignos e composições contendo os mesmos |
EP98952503A EP1027375B1 (en) | 1997-10-21 | 1998-10-21 | Anti-idiotypic monoclonal antibodies, their use in the active immunotherapy of malignant tumors, and compositions containing them |
AT98952503T ATE341564T1 (de) | 1997-10-21 | 1998-10-21 | Anti-idiotypische monoklonale antikörper, deren verwendung zur aktiven immuntherapie bösartiger tumoren, und zusammensetzungen die diese enthalten |
KR1020007004270A KR100567209B1 (ko) | 1997-10-21 | 1998-10-21 | 안티-이디오타입 모노클로날 항체, 악성 종양의 능동면역치료법에서의 이들의 용도 및 이들을 함유하는 조성물 |
CA002308142A CA2308142C (en) | 1997-10-21 | 1998-10-21 | Anti-idiotype monoclonal antibodies, their use in active immunotherapy of malignant tumors and compositions containing them |
DK98952503T DK1027375T3 (da) | 1997-10-21 | 1998-10-21 | Anti-idiotypiske monoklonale antistoffer, anvendelse deraf til aktiv immunterapi af maligne tumorer samt præparater, som indeholder disse antistoffer |
JP2000516993A JP4304287B2 (ja) | 1997-10-21 | 1998-10-21 | 抗イディオタイプモノクローナル抗体、悪性腫瘍の能動免疫療法におけるそれらの使用、およびそれらを含有する組成物 |
US09/448,883 US6491914B1 (en) | 1993-12-09 | 1999-11-24 | Anti-idiotypic monoclonal antibodies, their use in the active immunotherapy of malignant tumors, and compositions including the anti-idiotypic monoclonal antibodies |
HK01104753A HK1034264A1 (en) | 1997-10-21 | 2001-07-10 | Anti-idiotype monoclonal antibodies, their use in active immunotherapy of malignant tumors and compositions containing them |
CY20061101788T CY1105844T1 (el) | 1997-10-21 | 2006-12-12 | Αντι-ιδιοτυπικα μονοκλωνα αντισωματα, η χρηση τους στην ενepγητικη ανοσοθepαπεια κακοηθων ογκων και συνθεσεις οι οποιες τα πepιεχουν |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU1997119A CU22702A1 (es) | 1997-10-21 | 1997-10-21 | Anticuerpos monoclonales anti - idiotipo, su uso en la inmunoterapia activa de tumores malignos, hibridoma que los produce y composiciones que los contienen |
Publications (1)
Publication Number | Publication Date |
---|---|
CU22702A1 true CU22702A1 (es) | 2001-07-31 |
Family
ID=5459399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU1997119A CU22702A1 (es) | 1993-12-09 | 1997-10-21 | Anticuerpos monoclonales anti - idiotipo, su uso en la inmunoterapia activa de tumores malignos, hibridoma que los produce y composiciones que los contienen |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP1027375B1 (es) |
JP (1) | JP4304287B2 (es) |
KR (1) | KR100567209B1 (es) |
CN (1) | CN1210309C (es) |
AR (1) | AR017369A1 (es) |
AT (1) | ATE341564T1 (es) |
AU (1) | AU1019999A (es) |
BR (1) | BR9812974A (es) |
CA (1) | CA2308142C (es) |
CO (1) | CO5060487A1 (es) |
CU (1) | CU22702A1 (es) |
CY (1) | CY1105844T1 (es) |
DE (1) | DE69836096T2 (es) |
DK (1) | DK1027375T3 (es) |
EA (1) | EA003366B1 (es) |
ES (1) | ES2274584T3 (es) |
HK (1) | HK1034264A1 (es) |
PT (1) | PT1027375E (es) |
SI (1) | SI1027375T1 (es) |
WO (1) | WO1999020656A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CU23007A1 (es) * | 2001-04-06 | 2004-12-17 | Ct De Inmunologia Molecular Ct De Inmunologia Mole | Combinaciones inmunoterapéuticas para el tratamiencombinaciones inmunoterapéuticas para el tratamiento de tumores que sobre-expresan gangliósidos to de tumores que sobre-expresan gangliósidos |
WO2011051466A1 (en) * | 2009-11-02 | 2011-05-05 | Novartis Ag | Anti-idiotypic fibronectin-based binding molecules and uses thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993010221A1 (en) * | 1991-11-13 | 1993-05-27 | The Regents Of The University Of California | Chimeric murine/human anti-idiotype monoclonal antibodies |
US5653977A (en) * | 1993-09-09 | 1997-08-05 | Uab Research Foundation | Anti-idiotypic antibody that mimics the GD2 antigen |
ES2166770T3 (es) * | 1993-12-09 | 2002-05-01 | Centro Inmunologia Molecular | Anticuerpos monoclonales contra gangliosidos y sus utilizaciones en la inmunoterapia activa especifica de tumores malignos. |
CU22420A1 (es) * | 1993-12-29 | 1996-01-31 | Centro Inmunologia Molecular | Composicion vacunal para el desarrollo de una respuesta contra gangliosidos n glicolilados y su uso para el tratamiento del cancer |
CU22585A1 (es) * | 1995-11-17 | 1999-11-03 | Centro Inmunologia Molecular | Anticuerpos monoclonales antiidiótipos (ab2) de tipo igg con alta conectividad idiotípica y composiciones farmacéuticas que los contienen. su uso como inmunoreguladores de la respuesta inmune. |
US5792455A (en) * | 1996-03-21 | 1998-08-11 | Sloan-Kettering Institute For Cancer Research | Anti-idiotypic antibody vaccines |
-
1997
- 1997-10-21 CU CU1997119A patent/CU22702A1/es unknown
-
1998
- 1998-10-20 AR ARP980105212A patent/AR017369A1/es active IP Right Grant
- 1998-10-20 CO CO98060820A patent/CO5060487A1/es unknown
- 1998-10-21 CN CNB988114887A patent/CN1210309C/zh not_active Expired - Lifetime
- 1998-10-21 SI SI9830866T patent/SI1027375T1/sl unknown
- 1998-10-21 DE DE69836096T patent/DE69836096T2/de not_active Expired - Lifetime
- 1998-10-21 DK DK98952503T patent/DK1027375T3/da active
- 1998-10-21 JP JP2000516993A patent/JP4304287B2/ja not_active Expired - Lifetime
- 1998-10-21 AT AT98952503T patent/ATE341564T1/de active
- 1998-10-21 BR BR9812974-0A patent/BR9812974A/pt not_active IP Right Cessation
- 1998-10-21 ES ES98952503T patent/ES2274584T3/es not_active Expired - Lifetime
- 1998-10-21 PT PT98952503T patent/PT1027375E/pt unknown
- 1998-10-21 WO PCT/CU1998/000007 patent/WO1999020656A1/es active IP Right Grant
- 1998-10-21 EP EP98952503A patent/EP1027375B1/en not_active Expired - Lifetime
- 1998-10-21 CA CA002308142A patent/CA2308142C/en not_active Expired - Lifetime
- 1998-10-21 KR KR1020007004270A patent/KR100567209B1/ko not_active IP Right Cessation
- 1998-10-21 AU AU10199/99A patent/AU1019999A/en not_active Abandoned
- 1998-10-21 EA EA200000442A patent/EA003366B1/ru not_active IP Right Cessation
-
2001
- 2001-07-10 HK HK01104753A patent/HK1034264A1/xx not_active IP Right Cessation
-
2006
- 2006-12-12 CY CY20061101788T patent/CY1105844T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
EA003366B1 (ru) | 2003-04-24 |
CO5060487A1 (es) | 2001-07-30 |
CN1279692A (zh) | 2001-01-10 |
EP1027375B1 (en) | 2006-10-04 |
ES2274584T3 (es) | 2007-05-16 |
DE69836096D1 (de) | 2006-11-16 |
PT1027375E (pt) | 2007-01-31 |
CA2308142A1 (en) | 1999-04-29 |
KR100567209B1 (ko) | 2006-04-03 |
KR20010031283A (ko) | 2001-04-16 |
DE69836096T2 (de) | 2007-05-16 |
CY1105844T1 (el) | 2011-02-02 |
ATE341564T1 (de) | 2006-10-15 |
CA2308142C (en) | 2005-06-14 |
BR9812974A (pt) | 2000-08-08 |
AU1019999A (en) | 1999-05-10 |
JP2001520034A (ja) | 2001-10-30 |
DK1027375T3 (da) | 2007-02-05 |
WO1999020656A1 (es) | 1999-04-29 |
CN1210309C (zh) | 2005-07-13 |
JP4304287B2 (ja) | 2009-07-29 |
SI1027375T1 (sl) | 2007-02-28 |
HK1034264A1 (en) | 2001-10-19 |
EA200000442A1 (ru) | 2000-10-30 |
EP1027375A1 (en) | 2000-08-16 |
AR017369A1 (es) | 2001-09-05 |
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