ATE58554T1 - Menschlicher hybridomfusionspartner zur herstellung menschlicher monoklonaler antikoerper. - Google Patents

Menschlicher hybridomfusionspartner zur herstellung menschlicher monoklonaler antikoerper.

Info

Publication number
ATE58554T1
ATE58554T1 AT85306493T AT85306493T ATE58554T1 AT E58554 T1 ATE58554 T1 AT E58554T1 AT 85306493 T AT85306493 T AT 85306493T AT 85306493 T AT85306493 T AT 85306493T AT E58554 T1 ATE58554 T1 AT E58554T1
Authority
AT
Austria
Prior art keywords
human
hybridom
production
monoclonal antibodies
fusion partner
Prior art date
Application number
AT85306493T
Other languages
English (en)
Inventor
Danuta Kozbor
Carlo M Croce
Original Assignee
Wistar Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wistar Inst filed Critical Wistar Inst
Application granted granted Critical
Publication of ATE58554T1 publication Critical patent/ATE58554T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/948—Microorganisms using viruses or cell lines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT85306493T 1984-11-20 1985-09-12 Menschlicher hybridomfusionspartner zur herstellung menschlicher monoklonaler antikoerper. ATE58554T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/673,370 US4693975A (en) 1984-11-20 1984-11-20 Human hybridroma fusion partner for production of human monoclonal antibodies
EP85306493A EP0182467B1 (de) 1984-11-20 1985-09-12 Menschlicher Hybridomfusionspartner zur Herstellung menschlicher monoklonaler Antikörper

Publications (1)

Publication Number Publication Date
ATE58554T1 true ATE58554T1 (de) 1990-12-15

Family

ID=24702377

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85306493T ATE58554T1 (de) 1984-11-20 1985-09-12 Menschlicher hybridomfusionspartner zur herstellung menschlicher monoklonaler antikoerper.

Country Status (7)

Country Link
US (1) US4693975A (de)
EP (1) EP0182467B1 (de)
JP (1) JPS61128886A (de)
AT (1) ATE58554T1 (de)
AU (1) AU577745B2 (de)
CA (1) CA1245581A (de)
DE (1) DE3580654D1 (de)

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IL70686A (en) * 1983-01-20 1988-07-31 Suntory Ltd Mutant tumor cell lines for use in the preparation of hybridomas and the hybridomas obtained therefrom
JPH0798000B2 (ja) * 1987-05-23 1995-10-25 萩原 義秀 ガン関連抗原特異的ヒト免疫グロブリン
US5001065A (en) * 1987-05-27 1991-03-19 Cetus Corporation Human cell line and triomas, antibodies, and transformants derived therefrom
JPH0249597A (ja) * 1988-04-27 1990-02-19 Kimiyoshi Tsuji モノクローナル抗体及びその利用方法
CA2002067A1 (en) * 1988-11-09 1990-05-09 Tamotsu Fukuda Parent cell line for producing human hybridomas
US6274552B1 (en) 1993-03-18 2001-08-14 Cytimmune Sciences, Inc. Composition and method for delivery of biologically-active factors
US20010055581A1 (en) * 1994-03-18 2001-12-27 Lawrence Tamarkin Composition and method for delivery of biologically-active factors
US7229841B2 (en) * 2001-04-30 2007-06-12 Cytimmune Sciences, Inc. Colloidal metal compositions and methods
US6407218B1 (en) 1997-11-10 2002-06-18 Cytimmune Sciences, Inc. Method and compositions for enhancing immune response and for the production of in vitro mabs
JP2008504216A (ja) * 2003-12-02 2008-02-14 サイトイミューン サイエンシズ インコーポレイテッド モノクローナル抗体の生成のための方法および組成物
JP4833862B2 (ja) * 2004-01-28 2011-12-07 サイトイミューン サイエンシズ インコーポレイテッド 官能化コロイド金属組成物および方法
WO2007016548A2 (en) 2005-08-01 2007-02-08 The Ohio State University Research Foundation Micro-rna-based methods and compositions for the diagnosis, prognosis and treatment of breast cancer
AU2006291165B2 (en) 2005-09-12 2013-03-14 The Ohio State University Research Foundation Compositions and methods for the diagnosis and therapy of BCL2-associated cancers
AU2007205234B2 (en) 2006-01-05 2012-07-12 The Ohio State University Research Foundation MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer
CA2635616A1 (en) 2006-01-05 2007-07-19 Carlo M. Croce Microrna expression abnormalities in pancreatic endocrine and acinar tumors
ES2508893T3 (es) 2006-01-05 2014-10-16 The Ohio State University Research Foundation Métodos basados en microARN para el diagnóstico de cánceres de estómago
EP2369011A1 (de) 2006-03-20 2011-09-28 The Ohio State University Research Foundation Miko-RNA-Fingerabdrücke während humaner Megakaryozytopoiese
EP2041317A4 (de) * 2006-07-13 2009-10-14 Univ Ohio State Res Found Mikro-rna-basierte verfahren und zusammensetzungen zur diagnose und behandlung von erkrankungen in zusammenhang mit darmkrebs
AU2007346101B2 (en) * 2006-09-19 2013-08-15 The Ohio State University Research Foundation TCL1 expression in chronic lymphocytic leukemia (CLL) regulated by miR-29 and miR-181
US8252538B2 (en) 2006-11-01 2012-08-28 The Ohio State University MicroRNA expression signature for predicting survival and metastases in hepatocellular carcinoma
WO2008094545A2 (en) 2007-01-31 2008-08-07 The Ohio State University Research Foundation Mic orna-based methods and compositions for the treatment of acute myeloid leukemia
CN101711287B (zh) 2007-06-08 2016-04-27 由卫生与公众服务部代表的美利坚合众国政府 确定肝细胞癌亚型和检测肝癌干细胞的方法
AU2008266014B2 (en) 2007-06-15 2013-06-06 The Ohio State University Research Foundation Oncogenic ALL-1 fusion proteins for targeting drosha-mediated microRNA processing
US8367632B2 (en) 2007-07-31 2013-02-05 Ohio State University Research Foundation Methods for reverting methylation by targeting methyltransferases
AU2008283997B2 (en) 2007-08-03 2014-04-10 The Ohio State University Research Foundation Ultraconserved regions encoding ncRNAs
AU2008284015B2 (en) 2007-08-03 2014-05-15 Musc Foundation For Research Development Human monoclonal antibodies and methods for producing the same
ES2562078T3 (es) 2007-08-22 2016-03-02 The Ohio State University Research Foundation Métodos y composiciones para inducir la desregulación de la fosforilación de EphA7 y ERK en leucemias agudas humanas
CA2700378A1 (en) * 2007-09-21 2009-03-29 Cytimmune Sciences, Inc. Nanotherapeutic colloidal metal compositions and methods
US20110014118A1 (en) * 2007-09-21 2011-01-20 Lawrence Tamarkin Nanotherapeutic colloidal metal compositions and methods
CA2703707A1 (en) 2007-10-26 2009-04-30 The Ohio State University Research Foundation Methods for identifying fragile histidine triad (fhit) interaction and uses thereof
WO2009062151A1 (en) 2007-11-08 2009-05-14 Cytimmune Sciences, Inc. Compositions and methods for generating antibodies
EP2307028B1 (de) 2008-06-11 2013-10-02 The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services Verwendung der mir-26-familie als prädiktiver marker für hepatozelluläres karzinom und des ansprechens auf die therapie
JP5960060B2 (ja) 2009-11-23 2016-08-02 ジ・オハイオ・ステート・ユニバーシティ 腫瘍細胞の増殖、遊走および浸潤に影響を与えるために有用な物質および方法
US8493081B2 (en) * 2009-12-08 2013-07-23 Magna Closures Inc. Wide activation angle pinch sensor section and sensor hook-on attachment principle
CN103648505B (zh) 2010-11-12 2016-09-28 俄亥俄州立大学研究基金会 与微rna-21、错配修复和结肠直肠癌相关的材料和方法
EP2640368B1 (de) 2010-11-15 2020-12-30 The Ohio State University Research Foundation Mukoadhäsive systeme mit kontrollierter freisetzung
CN103561750A (zh) 2011-03-07 2014-02-05 俄亥俄州立大学 通过microRNA-155(miR-155)诱导的增变活性使炎症与癌症关联
AU2012323924A1 (en) 2011-10-14 2014-05-29 The Ohio State University Methods and materials related to ovarian cancer
EP2790735A4 (de) 2011-12-13 2015-12-09 Ohio State Innovation Foundation Verfahren und zusammensetzungen im zusammenhang mit mir-21 und mir-29a, exosomerhemmung und krebsmetastasen
WO2013110053A1 (en) 2012-01-20 2013-07-25 The Ohio State University Breast cancer biomarker signatures for invasiveness and prognosis

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2079313A (en) * 1980-07-07 1982-01-20 Nat Res Dev Improvements in or relating to rat myeloma cell lines
CH652145A5 (de) * 1982-01-22 1985-10-31 Sandoz Ag Verfahren zur in vitro-herstellung von hybridomen welche humane monoklonale antikoerper erzeugen.
US4529694A (en) * 1982-04-16 1985-07-16 The Children's Medical Center Corporation Cell fusion
US4574116A (en) * 1983-01-13 1986-03-04 The Board Of Trustees Of The Leland Stanford Jr. University Methods and cell lines for immortalization and monoclonal antibody production by antigen-stimulated B-lymphocytes
IL70686A (en) * 1983-01-20 1988-07-31 Suntory Ltd Mutant tumor cell lines for use in the preparation of hybridomas and the hybridomas obtained therefrom
JPS59169489A (ja) * 1983-03-15 1984-09-25 Otsuka Pharmaceut Co Ltd ヒト培養株化細胞
JPS6054687A (ja) * 1983-07-19 1985-03-29 スロ−ン−ケツタリング　インステイテユ−ト　フオ−　キヤンサ−　リサ−チ ヒト　モノクロ−ン抗体の製法
NO861491L (no) * 1985-04-22 1986-10-23 Hybritech Inc Antistoff, fremgangsmaate for dets fremstilling og anvendelse for deteksjon og diagnose av canser.

Also Published As

Publication number Publication date
DE3580654D1 (de) 1991-01-03
JPS61128886A (ja) 1986-06-16
AU5007885A (en) 1986-05-29
AU577745B2 (en) 1988-09-29
CA1245581A (en) 1988-11-29
EP0182467B1 (de) 1990-11-22
EP0182467A2 (de) 1986-05-28
US4693975A (en) 1987-09-15
EP0182467A3 (en) 1987-09-16

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee