ES2194203T3 - Ligando del receptor tie-2 (ligando-4 de tie) y su uso. - Google Patents
Ligando del receptor tie-2 (ligando-4 de tie) y su uso.Info
- Publication number
- ES2194203T3 ES2194203T3 ES97930162T ES97930162T ES2194203T3 ES 2194203 T3 ES2194203 T3 ES 2194203T3 ES 97930162 T ES97930162 T ES 97930162T ES 97930162 T ES97930162 T ES 97930162T ES 2194203 T3 ES2194203 T3 ES 2194203T3
- Authority
- ES
- Spain
- Prior art keywords
- tie
- procedure
- growth
- binding
- receiver
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102100022014 Angiopoietin-1 receptor Human genes 0.000 title 1
- 101000753291 Homo sapiens Angiopoietin-1 receptor Proteins 0.000 title 1
- 230000012010 growth Effects 0.000 abstract 3
- 230000004069 differentiation Effects 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 101100478175 Arabidopsis thaliana SPEAR2 gene Proteins 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 210000004204 blood vessel Anatomy 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/165—Coronaviridae, e.g. avian infectious bronchitis virus
- C07K14/17—Porcine transmissible gastroenteritis virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/515—Angiogenesic factors; Angiogenin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Cell Biology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA PRESENTE INVENCION PROPORCIONA UNA MOLECULA DE ACIDO NUCLEICO AISLADA, QUE CODIFICA PARA UN MIEMBRO DE LA FAMILIA DE LIGANDOS TIE. LA INVENCION PROPORCIONA ASIMISMO UNA MOLECULA DE ACIDO NUCLEICO AISLADA QUE CODIFICA PARA EL LIGANDO TIE-3 O TIE4. ASIMISMO, SE PROPORCIONA UN ANTICUERPO QUE SE UNE ESPECIFICAMENTE A DICHOS LIGANDOS, Y UN ANTAGONISTA DE TIE; COMPOSICIONES TERAPEUTICAS ASI COMO UN PROCEDIMIENTO PARA BLOQUEAR EL CRECIMIENTO DE LOS VASOS SANGUINEOS, UN PROCEDIMIENTO PARA FAVORECER LA NEOVASCULARIZACION; UN PROCEDIMIENTO PARA INCREMENTAR EL CRECIMIENTO O DIFERENCIACION DE UNA CELULA QUE EXPRESA EL RECEPTOR TIE; UN PROCEDIMIENTO PARA BLOQUEAR EL CRECIMIENTO O DIFERENCIACION DE UNA CELULA QUE EXPRESA EL FACTOR TIE; Y UN PROCEDIMIENTO PARA ATENUAR O PREVENIR EL CRECIMIENTO TUMORAL EN HUMANOS.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/665,926 US5851797A (en) | 1996-06-19 | 1996-06-19 | Tie ligand-3, methods of making and uses thereof |
US2108796P | 1996-07-02 | 1996-07-02 | |
US2299996P | 1996-08-02 | 1996-08-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2194203T3 true ES2194203T3 (es) | 2003-11-16 |
Family
ID=27361571
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97930162T Expired - Lifetime ES2194203T3 (es) | 1996-06-19 | 1997-06-19 | Ligando del receptor tie-2 (ligando-4 de tie) y su uso. |
Country Status (20)
Country | Link |
---|---|
US (2) | US6432667B1 (es) |
EP (1) | EP0939809B1 (es) |
JP (1) | JP2000513932A (es) |
KR (1) | KR20000022028A (es) |
CN (1) | CN1227603A (es) |
AT (1) | ATE235551T1 (es) |
AU (1) | AU724467B2 (es) |
CA (1) | CA2258526A1 (es) |
CZ (1) | CZ421898A3 (es) |
DE (1) | DE69720241T2 (es) |
DK (1) | DK0939809T3 (es) |
ES (1) | ES2194203T3 (es) |
FI (1) | FI982745A (es) |
HU (1) | HUP0004320A3 (es) |
IL (1) | IL127623A0 (es) |
NO (1) | NO985904L (es) |
NZ (1) | NZ333374A (es) |
PL (1) | PL330705A1 (es) |
PT (1) | PT939809E (es) |
WO (1) | WO1997048804A2 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6350450B1 (en) | 1997-09-19 | 2002-02-26 | Genentech, Inc. | TIE ligand homologue antibody |
US5972338A (en) | 1997-09-19 | 1999-10-26 | Genentech, Inc. | Tie ligands homologues |
US6057435A (en) * | 1997-09-19 | 2000-05-02 | Genentech, Inc. | Tie ligand homologues |
US6030831A (en) * | 1997-09-19 | 2000-02-29 | Genetech, Inc. | Tie ligand homologues |
US6348350B1 (en) | 1997-09-19 | 2002-02-19 | Genentech, Inc. | Ligand homologues |
WO1999067382A2 (en) * | 1998-06-24 | 1999-12-29 | Compugen Ltd. | Angiopoietin-like growth factor sequences |
ES2242437T3 (es) * | 1998-11-20 | 2005-11-01 | Genentech, Inc. | Utilizaciones de agonistas y antagonistas del receptor eph para el tratamiento de trastornos vasculares. |
SI1135153T1 (es) * | 1998-11-20 | 2005-08-31 | Genentech Inc | |
EP1141294B1 (en) | 1998-12-23 | 2005-03-02 | Regeneron Pharmaceuticals, Inc. | Method of enhancing the biological activity of ligands |
US7052695B2 (en) | 2001-10-25 | 2006-05-30 | Regeneron Pharmaceuticals, Inc. | Angiopoietins and methods of treating hypertension |
US8298532B2 (en) | 2004-01-16 | 2012-10-30 | Regeneron Pharmaceuticals, Inc. | Fusion polypeptides capable of activating receptors |
US7296991B2 (en) * | 2004-12-10 | 2007-11-20 | Irwin Jere F | Adjustable extruder die assembly die lip adjustment apparatus |
US20080119367A1 (en) * | 2004-12-17 | 2008-05-22 | Mayo Foundation For Medical Education And Research | Prognosis of Renal Cell Carcinoma |
WO2007030658A2 (en) * | 2005-09-08 | 2007-03-15 | Children's Hospital Medical Center | Compositions useful for and methods of modulating angiogenesis |
US20080080059A1 (en) * | 2006-09-28 | 2008-04-03 | Pacific Biosciences Of California, Inc. | Modular optical components and systems incorporating same |
CA3038602C (en) | 2015-09-29 | 2023-12-05 | ProdrugXtend Pty Ltd | Extended-release formulations comprising 6-thioguanine |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5332671A (en) | 1989-05-12 | 1994-07-26 | Genetech, Inc. | Production of vascular endothelial cell growth factor and DNA encoding same |
WO1994000469A1 (en) | 1992-06-26 | 1994-01-06 | Immunex Corporation | Novel tyrosine kinase |
CN1173991C (zh) | 1992-11-13 | 2004-11-03 | 马克斯普朗克科学促进协会 | 作为血管内皮生长因子受体的f1k-1 |
US5643755A (en) * | 1994-10-07 | 1997-07-01 | Regeneron Pharmaceuticals Inc. | Nucleic acid encoding tie-2 ligand |
US5814464A (en) * | 1994-10-07 | 1998-09-29 | Regeneron Pharma | Nucleic acids encoding TIE-2 ligand-2 |
NZ300808A (en) * | 1994-12-23 | 1999-04-29 | Ludwig Inst Cancer Res | A method of detecting a ligand capable of binding the receptor protein nyk |
ATE273384T1 (de) | 1995-04-06 | 2004-08-15 | Regeneron Pharma | Tie-2 liganden, herstellungsverfahren und verwendung |
US5851797A (en) * | 1996-06-19 | 1998-12-22 | Regeneron Pharmaceuticals, Inc. | Tie ligand-3, methods of making and uses thereof |
-
1997
- 1997-06-19 EP EP97930162A patent/EP0939809B1/en not_active Expired - Lifetime
- 1997-06-19 US US09/202,491 patent/US6432667B1/en not_active Expired - Lifetime
- 1997-06-19 NZ NZ333374A patent/NZ333374A/en unknown
- 1997-06-19 CZ CZ984218A patent/CZ421898A3/cs unknown
- 1997-06-19 JP JP10503376A patent/JP2000513932A/ja not_active Withdrawn
- 1997-06-19 CN CN97197208A patent/CN1227603A/zh active Pending
- 1997-06-19 HU HU0004320A patent/HUP0004320A3/hu unknown
- 1997-06-19 AU AU34061/97A patent/AU724467B2/en not_active Ceased
- 1997-06-19 KR KR1019980710426A patent/KR20000022028A/ko not_active Application Discontinuation
- 1997-06-19 CA CA002258526A patent/CA2258526A1/en not_active Abandoned
- 1997-06-19 DK DK97930162T patent/DK0939809T3/da active
- 1997-06-19 AT AT97930162T patent/ATE235551T1/de not_active IP Right Cessation
- 1997-06-19 PL PL97330705A patent/PL330705A1/xx unknown
- 1997-06-19 ES ES97930162T patent/ES2194203T3/es not_active Expired - Lifetime
- 1997-06-19 IL IL12762397A patent/IL127623A0/xx unknown
- 1997-06-19 DE DE69720241T patent/DE69720241T2/de not_active Expired - Fee Related
- 1997-06-19 WO PCT/US1997/010728 patent/WO1997048804A2/en not_active Application Discontinuation
- 1997-06-19 PT PT97930162T patent/PT939809E/pt unknown
-
1998
- 1998-12-16 NO NO985904A patent/NO985904L/no not_active Application Discontinuation
- 1998-12-18 FI FI982745A patent/FI982745A/fi unknown
-
2002
- 2002-08-08 US US10/214,812 patent/US6881395B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69720241D1 (de) | 2003-04-30 |
ATE235551T1 (de) | 2003-04-15 |
JP2000513932A (ja) | 2000-10-24 |
EP0939809B1 (en) | 2003-03-26 |
DE69720241T2 (de) | 2003-12-11 |
EP0939809A2 (en) | 1999-09-08 |
IL127623A0 (en) | 1999-10-28 |
HUP0004320A2 (hu) | 2001-06-28 |
WO1997048804A3 (en) | 1998-04-09 |
NZ333374A (en) | 2000-06-23 |
KR20000022028A (ko) | 2000-04-25 |
PL330705A1 (en) | 1999-05-24 |
AU3406197A (en) | 1998-01-07 |
PT939809E (pt) | 2003-08-29 |
FI982745A0 (fi) | 1998-12-18 |
DK0939809T3 (da) | 2003-07-21 |
FI982745A (fi) | 1999-02-04 |
US6432667B1 (en) | 2002-08-13 |
AU724467B2 (en) | 2000-09-21 |
WO1997048804A2 (en) | 1997-12-24 |
NO985904L (no) | 1999-02-19 |
NO985904D0 (no) | 1998-12-16 |
CN1227603A (zh) | 1999-09-01 |
HUP0004320A3 (en) | 2005-11-28 |
CZ421898A3 (cs) | 1999-05-12 |
US20030064470A1 (en) | 2003-04-03 |
CA2258526A1 (en) | 1997-12-24 |
US6881395B2 (en) | 2005-04-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2194203T3 (es) | Ligando del receptor tie-2 (ligando-4 de tie) y su uso. | |
ES2058083T3 (es) | Anticuerpos monoclonales contra el factor humano de la necrosis tumoral (tnf) y su empleo. | |
TR200100149T2 (tr) | Dual anjiyotensin endotelin alıcı antagonistleri olarak bifenil-sülfonamitler | |
ES2154354T3 (es) | Ligandos tie-2, metodos para obtenerlos y sus usos. | |
AR027060A1 (es) | Bases de mannich de 1-naftol y 2-naftol sustituidos, procedimiento para su preparacion, medicamentos que contienen estos compuestos, asi como el uso deestos compuestos para la fabricacion de medicamentos | |
CR8673A (es) | Compuestos de difenil-ox-indol-2-ona y su uso en el tratamiento del cancer | |
BR0209689A (pt) | Uso de fragmento de hmg como agente anti-inflamatório | |
MX9307974A (es) | Nuevos derivados de acido hidroxiiminoalquilindolcarboxilico, su obtencion y uso. | |
BRPI0510716A (pt) | uso de um agente de ligação bi-especìfico, agente de ligação bi-especìfico, composição de um agente de ligação bi-especìfico, e, kit | |
EA200000251A1 (ru) | Производные резорцинола | |
EA200200530A1 (ru) | Гетероциклические замещенные пиразолоны | |
ES2185705T3 (es) | Proteina bifuncional, preparacion y uso. | |
EA199800563A1 (ru) | Антагонисты гормона, высвобождающего гонадотропин | |
CY1114944T1 (el) | Σταθεροποιημενα αλφα ελικοειδη πεπτιδια και χρησεις αυτων | |
CR10147A (es) | "ligandos que tienen especificidad de enlace para vegf y/o egfr y métodos de uso de los mismos" | |
AR030760A1 (es) | Nuevos acidos y polipeptidos nucleicos receptores | |
PE20060127A1 (es) | Sistema de entrega de farmacos constituido por copolimero de polietileno acetato de vinilo | |
SV2002000249A (es) | Derivados de tiazolilamida ref, lea 34082-sv | |
ES2126618T3 (es) | Procedimiento para el aislamiento y cultivo de celulas transformadas asi como empleo de estas celulas para la obtencion de anticuerpos especificos para el individuo. | |
DE69524103T2 (de) | Fluorinierte 2-nitroimidazole analoge zur detektion von hypoxischen tumorzellen | |
PA8633601A1 (es) | Profarmacos de esteroides con accion androgenica | |
WO2003105773A3 (en) | MUTATIONS OF PDGFRA ACTIVATED AS DIAGNOSTIC MARKERS AND THERAPEUTIC TARGETS | |
CO5150178A1 (es) | Bromohidrato de eletriptan monohidrato y procedimiento para su preparacion | |
WO2005080426A3 (en) | Protein ligands for nkg2d and ul16 receptors and uses thereof | |
BR9710849A (pt) | Vacina contendo uma peróxi-redoxina e/ou uma beta-tubulina. |