UY24285A1 - Procedimiento para la preparación de ácido cristalino - Google Patents

Procedimiento para la preparación de ácido cristalino

Info

Publication number
UY24285A1
UY24285A1 UY24285A UY24285A UY24285A1 UY 24285 A1 UY24285 A1 UY 24285A1 UY 24285 A UY24285 A UY 24285A UY 24285 A UY24285 A UY 24285A UY 24285 A1 UY24285 A1 UY 24285A1
Authority
UY
Uruguay
Prior art keywords
preparation
phenylamino
fluorophenyl
pyrrole
dihydroxy
Prior art date
Application number
UY24285A
Other languages
English (en)
Inventor
Christopher Briggs
jennings A
Robert WADE
Rex Allen
Kikuko Harasawa
Kazuo Ichikawa
Kazuo Minohara
Shinsuke Nakagawa
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21696090&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY24285(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of UY24285A1 publication Critical patent/UY24285A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Un proceso para la preparación de atorvastatina cristalina de forma l caracterizado por comprender: a- tratar una solución acuosa de una sal basica de ácido [R-(R*, R*)]-2-(4-fluorofenil)beta, gamma-dihidroxi-5-(1-metil etil)-3-fenil-4-[(fenilamino)carbonil]1H-pirrol-1-heptanoico con una sal de calcio; y b- aislar la atorvastatina cristalina de forma l. Un proceso caracterizado por que en el paso (a) se agregan semillas de atorvastina critalina de forma l durante o después de tratar la solución acuosa de una sal básica de ácido [R-(R*, R*)]-2-(4-fluorofenil)beta, gamma-dihidroxi-5-(1-metiletil)-3-fenil-4-(fenilamino)carbonil] 1H-pirrol-1-heptanoico con una sal de calcio, también se caracteriza por su difracción de polvo en rayos X y/o por su RMN de estado sólido y sus composiciones farmacéuticas que sirven como agente para tratar la hiperlipidemia e hipercolesterolemia.
UY24285A 1995-07-17 1996-07-17 Procedimiento para la preparación de ácido cristalino UY24285A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US145295P 1995-07-17 1995-07-17

Publications (1)

Publication Number Publication Date
UY24285A1 true UY24285A1 (es) 1997-01-17

Family

ID=21696090

Family Applications (2)

Application Number Title Priority Date Filing Date
UY24285A UY24285A1 (es) 1995-07-17 1996-07-17 Procedimiento para la preparación de ácido cristalino
UY24985A UY24985A1 (es) 1995-07-17 1998-04-30 Formas cristalinas hidratadas de atorvastatina forma i

Family Applications After (1)

Application Number Title Priority Date Filing Date
UY24985A UY24985A1 (es) 1995-07-17 1998-04-30 Formas cristalinas hidratadas de atorvastatina forma i

Country Status (38)

Country Link
US (1) US5969156A (es)
EP (2) EP1148049B1 (es)
JP (4) JP3296564B2 (es)
KR (2) KR100389518B1 (es)
CN (1) CN1087288C (es)
AR (2) AR003459A1 (es)
AT (3) ATE208375T1 (es)
AU (1) AU725424B2 (es)
BG (1) BG63630B1 (es)
BR (1) BR9609872A (es)
CA (1) CA2220018C (es)
CO (1) CO4700443A1 (es)
CY (1) CY2358B1 (es)
CZ (3) CZ294740B6 (es)
DE (2) DE69634054T2 (es)
DK (2) DK1148049T3 (es)
EA (1) EA000474B1 (es)
EE (1) EE03606B1 (es)
ES (2) ES2233526T3 (es)
GE (1) GEP20002029B (es)
HK (1) HK1018052A1 (es)
HR (1) HRP960339B1 (es)
HU (1) HU223599B1 (es)
IL (7) IL128864A (es)
MX (1) MX9709099A (es)
NO (1) NO309898B1 (es)
NZ (1) NZ312907A (es)
PE (1) PE1898A1 (es)
PL (1) PL193479B1 (es)
PT (2) PT848705E (es)
RO (1) RO120070B1 (es)
SI (2) SI0848705T1 (es)
SK (1) SK284202B6 (es)
TW (1) TW486467B (es)
UA (1) UA51661C2 (es)
UY (2) UY24285A1 (es)
WO (1) WO1997003959A1 (es)
ZA (1) ZA966044B (es)

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