IN191236B - - Google Patents
Info
- Publication number
- IN191236B IN191236B IN775DE1999A IN191236B IN 191236 B IN191236 B IN 191236B IN 775DE1999 A IN775DE1999 A IN 775DE1999A IN 191236 B IN191236 B IN 191236B
- Authority
- IN
- India
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN775DE1999 IN191236B (es) | 1999-05-25 | 1999-05-25 | |
PCT/IB2000/000014 WO2000071116A1 (en) | 1999-05-25 | 2000-01-06 | Process for the production of amorphous atorvastatin calcium |
CNA2005100525833A CN1680315A (zh) | 1999-05-25 | 2000-01-06 | 无定形阿托伐斯汀钙的制备方法 |
US09/979,475 US6528660B1 (en) | 1999-05-25 | 2000-01-06 | Process for the production of amorphous atorvastatin calcium |
DK00900300T DK1185264T3 (da) | 1999-05-25 | 2000-01-06 | Fremgangsmåde til fremstilling af amorft atorvastatin-calcium |
AT00900300T ATE362759T1 (de) | 1999-05-25 | 2000-01-06 | Verfahren zur herstellung von amorphem atorvastatin kalzium |
EP00900300A EP1185264B1 (en) | 1999-05-25 | 2000-01-06 | Process for the production of amorphous atorvastatin calcium |
ES00900300T ES2284472T3 (es) | 1999-05-25 | 2000-01-06 | Procedimiento para la produccion de atorvastatina clacica amorfa. |
DE60034946T DE60034946T2 (de) | 1999-05-25 | 2000-01-06 | Verfahren zur herstellung von amorphem atorvastatin kalzium |
AU19967/00A AU778962B2 (en) | 1999-05-25 | 2000-01-06 | Process for the production of amorphous atorvastatin calcium |
PT00900300T PT1185264E (pt) | 1999-05-25 | 2000-01-06 | Processo para a produção de atorvastatina de cálcio amorfa |
BR0010923-1A BR0010923A (pt) | 1999-05-25 | 2000-01-06 | Processo para a produção de atorvastatina de cálcio amorfa |
CNB008080275A CN1196679C (zh) | 1999-05-25 | 2000-01-06 | 无定形阿托伐斯汀钙的制备方法 |
MYPI20002283A MY133511A (en) | 1999-05-25 | 2000-05-24 | Process for the production of amorphous atorvastatin calcium |
ZA200109656A ZA200109656B (en) | 1999-05-25 | 2001-11-23 | Process for the production of amorphous atorvastatin calcium. |
HK02106699.9A HK1045118A1 (zh) | 1999-05-25 | 2002-09-12 | 無定形的阿伐他汀鈣的製備方法 |
US10/378,574 US20030149279A1 (en) | 1999-05-25 | 2003-03-03 | Process for the production of amorphous atorvastatin calcium |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN775DE1999 IN191236B (es) | 1999-05-25 | 1999-05-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
IN191236B true IN191236B (es) | 2003-10-11 |
Family
ID=11091180
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN775DE1999 IN191236B (es) | 1999-05-25 | 1999-05-25 |
Country Status (15)
Country | Link |
---|---|
US (2) | US6528660B1 (es) |
EP (1) | EP1185264B1 (es) |
CN (2) | CN1196679C (es) |
AT (1) | ATE362759T1 (es) |
AU (1) | AU778962B2 (es) |
BR (1) | BR0010923A (es) |
DE (1) | DE60034946T2 (es) |
DK (1) | DK1185264T3 (es) |
ES (1) | ES2284472T3 (es) |
HK (1) | HK1045118A1 (es) |
IN (1) | IN191236B (es) |
MY (1) | MY133511A (es) |
PT (1) | PT1185264E (es) |
WO (1) | WO2000071116A1 (es) |
ZA (1) | ZA200109656B (es) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7411075B1 (en) | 2000-11-16 | 2008-08-12 | Teva Pharmaceutical Industries Ltd. | Polymorphic form of atorvastatin calcium |
SI20425A (sl) | 1999-12-10 | 2001-06-30 | LEK tovarna farmacevtskih in kemi�nih izdelkov d.d. | Priprava amorfnega atorvastatina |
IL156055A0 (en) | 2000-11-30 | 2003-12-23 | Teva Pharma | Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms |
US7501450B2 (en) | 2000-11-30 | 2009-03-10 | Teva Pharaceutical Industries Ltd. | Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms |
WO2002057228A1 (en) * | 2001-01-17 | 2002-07-25 | Biocon India Limited | Atorvastatin calcium |
SI20814A (sl) * | 2001-01-23 | 2002-08-31 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Priprava amorfnega atorvastatina |
IN190564B (es) * | 2001-04-11 | 2003-08-09 | Cadila Heathcare Ltd | |
RS100003A (en) * | 2001-06-29 | 2007-02-05 | Warner-Lambert Company, | Crystalline forms of /r-(r*,r*)-2-(4- fluorphenyl)-beta,delta -dihydroxy-5(1- methylethyl)-phenyl-4-/phenylamino) carbonyl/-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin) |
CA2456095C (en) | 2001-08-31 | 2010-05-11 | Morepen Laboratories Ltd. | An improved process for the preparation of amorphous atorvastatin calcium salt (2:1) |
UA77990C2 (en) * | 2001-12-12 | 2007-02-15 | Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid | |
CZ296967B6 (cs) | 2002-02-01 | 2006-08-16 | Zentiva, A.S. | Zpusob výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu) |
ITMI20020907A1 (it) * | 2002-04-29 | 2003-10-29 | Chemi Spa | Processo di preparazione della forma amorfa del sale di calcio della atorvastatina |
WO2003099785A1 (en) * | 2002-05-28 | 2003-12-04 | Cadila Healthcare Limited | Process for the preparation of amorphous atorvastatin calcium |
CA2520740C (en) | 2003-04-11 | 2012-06-05 | Lek Pharmaceuticals D.D. | Process for the preparation of amorphous calcium salt of atorvastatin |
AU2004234057A1 (en) * | 2003-04-29 | 2004-11-11 | Akzo Nobel N.V. | Antisolvent solidification process |
US7790197B2 (en) | 2003-06-09 | 2010-09-07 | Warner-Lambert Company Llc | Pharmaceutical compositions of atorvastatin |
US7655692B2 (en) | 2003-06-12 | 2010-02-02 | Pfizer Inc. | Process for forming amorphous atorvastatin |
US20050271717A1 (en) | 2003-06-12 | 2005-12-08 | Alfred Berchielli | Pharmaceutical compositions of atorvastatin |
CA2456430A1 (en) * | 2004-01-28 | 2005-07-28 | Brantford Chemicals Inc. | Improved process for the preparation of amorphous atorvastatin calcium |
CZ298382B6 (cs) * | 2004-03-10 | 2007-09-12 | Zentiva, A. S. | Zpusob prípravy amorfní formy hemivápenaté soli atorvastatinu a její stabilizace |
US7241800B2 (en) * | 2004-03-17 | 2007-07-10 | Mai De Ltd. | Anhydrous amorphous form of fluvastatin sodium |
PT1727795E (pt) | 2004-03-17 | 2012-04-11 | Ranbaxy Lab Ltd | Processo para a produção de atorvastatina cálcica na forma amorfa |
KR100829268B1 (ko) * | 2004-04-16 | 2008-05-13 | 화이자 프로덕츠 인코포레이티드 | 비정질 아토바스타틴 칼슘의 제조 방법 |
JP2007536373A (ja) | 2004-05-05 | 2007-12-13 | ファイザー・プロダクツ・インク | アトルバスタチンの塩形態 |
RU2412191C2 (ru) * | 2004-07-16 | 2011-02-20 | Лек Фармасьютиклз Д.Д. | Продукты окислительной деструкции кальций аторвастатина |
MX2007000765A (es) | 2004-07-20 | 2007-03-28 | Warner Lambert Co | Formas cristalinas de sal de calcio del acido (r-(r*, r*))-2- (4-fluorofenil)- beta,gama- dihidroxi-5- (1-metiletil)-3 -fenil-4-((fenilamino) (carbonil)-1ih -pirrol-1- heptanoico (2:1). |
CA2578722C (en) | 2004-08-27 | 2010-02-02 | Biocon Limited | Process for atorvastatin calcium amorphous |
US20060106230A1 (en) * | 2004-10-18 | 2006-05-18 | Michael Pinchasov | Processes for preparing amorphous atorvastatin hemi-calcium |
JP2008517992A (ja) * | 2004-10-28 | 2008-05-29 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | アモルファスのアトルバスタチンを形成する方法 |
WO2006048888A1 (en) * | 2004-11-01 | 2006-05-11 | Jubilant Organosys Limited | Novel process for the preparation of amorphous atorvastatin calcium salt |
US20090208539A1 (en) | 2004-11-22 | 2009-08-20 | Adel Penhasi | Stable atorvastatin formulations |
WO2007052296A2 (en) * | 2005-08-23 | 2007-05-10 | Kopran Research Laboratories Ltd | A process of preparing amorphous atorvastatin calcium |
US20090216029A1 (en) * | 2005-09-16 | 2009-08-27 | Yatendra Kumar | Process for the production of atorvastatin calcium in amorphous form |
CA2547216A1 (en) | 2005-09-21 | 2007-03-21 | Renuka D. Reddy | Process for annealing amorphous atorvastatin |
PT1957452E (pt) | 2005-11-21 | 2010-05-25 | Warner Lambert Co | Novas formas de ácido [r-(r*,r*)]-2-(4-fluorofenil)-b,b--di-hidroxi-5-(1-metiletil)-3-fenil-4-[(fenilamino)-carbonil]-1h-pirrole-1-heptanóico magnésico |
EP1810667A1 (en) | 2006-01-20 | 2007-07-25 | KRKA, tovarna zdravil, d.d., Novo mesto | Pharmaceutical composition comprising amorphous atorvastatin |
WO2008053312A2 (en) * | 2006-11-02 | 2008-05-08 | Cadila Pharmaceuticals Limited | Process for preparing amorphous atorvastatin hemi calcium salt and its intermediate |
US7834195B2 (en) | 2007-01-24 | 2010-11-16 | Apotex Pharmachem Inc. | Atorvastatin calcium propylene glycol solvates |
JP2010534644A (ja) * | 2007-07-27 | 2010-11-11 | シプラ・リミテッド | 医薬組成物およびその製造方法 |
EP2075246A1 (en) | 2007-12-27 | 2009-07-01 | M. J. Institute of Research | A process for preparation of amorphous form of atorvastatin hemi-calcium salt |
CN101684090B (zh) * | 2008-09-27 | 2012-12-05 | 广东东阳光药业有限公司 | 一种制备无定形阿托伐他汀钙的方法 |
US8115015B2 (en) | 2009-01-26 | 2012-02-14 | Cadila Healthcare Limited | Process for the preparation of amorphous atorvastatin calcium |
CZ201039A3 (cs) | 2010-01-19 | 2011-07-27 | Zentiva, K. S | Zpusob prumyslové výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu) s vysokým specifickým povrchem a jeho použití v lékové forme |
HUP1000299A2 (hu) | 2010-06-08 | 2012-02-28 | Nanoform Cardiovascular Therapeutics Ltd | Nanostrukturált Atorvastatint, gyógyszerészetileg elfogadott sóit és kokristályait tartalmazó készítmény és eljárás elõállításukra |
WO2016055934A1 (en) * | 2014-10-09 | 2016-04-14 | Glenmark Pharmaceuticals Limited | Amorphous form of lomitapide mesylate |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
YU44680B (en) * | 1982-07-30 | 1990-12-31 | Glaxo Lab Ltd | Process for obtaining very pure amorphous form of cephuroxim axetile |
US5097045A (en) | 1989-02-01 | 1992-03-17 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
US5149837A (en) | 1988-02-22 | 1992-09-22 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
US5245047A (en) | 1988-02-22 | 1993-09-14 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
US5003080A (en) | 1988-02-22 | 1991-03-26 | Warner-Lambert Company | Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis |
US5124482A (en) | 1988-02-22 | 1992-06-23 | Warner-Lambert Company | Process for trans-6-(2-substituted-pyrrol-1-yl)alkyl)pyran-2-one inhibitors of cholesterol synthesis |
FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
US5248793A (en) | 1990-10-17 | 1993-09-28 | Warner-Lambert Company | Process for the synthesis of (4R-cis)-1,1-dimethylethyl 6-iodomethyl or 6-(phenyl-substituted)sulfonyloxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate |
US5103024A (en) | 1990-10-17 | 1992-04-07 | Warner-Lambert Company | Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate |
US5298627A (en) | 1993-03-03 | 1994-03-29 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
EE03606B1 (et) | 1995-07-17 | 2002-02-15 | Warner-Lambert Company | Kristalliline [R-(R*,R*)]-2-(4-fluorofenüül)-beeta, delta-dihüdroksü-5-(1-metüületüül)-3-fenüül-4-[(fenüülamino)karbonüül]-1H-pürrool-1-hept aanhappehemikaltsiumsool (atorvastatiin) |
HRP960313B1 (en) * | 1995-07-17 | 2002-08-31 | Warner Lambert Co | Form iii crystalline (r- (r*, r*)-2- (4-fluorophenyl) -beta-delta-hydroxy-5-(1-methylethyl) -3-phenyl-4- ((phenylamino) carbonyl -1h-pyrrole-1-heptanoic acid calcium salt (2:1) |
HRP960312B1 (en) * | 1995-07-17 | 2001-10-31 | Warner Lambert Co | NOVEL PROCESS FOR THE PRODUCTION OF AMORPHOUS /R-(R*, R*)/-2-(4-FLUOROPHENYL)-"beta", "delta"-DIHYDROXY-5-PHENYL-4-/(PHENYLAMINO)CARBONYL/-1H-PYRROLE -1-HEPTANOIC ACID CALCIUM SALT (2 : 1) |
SI20425A (sl) * | 1999-12-10 | 2001-06-30 | LEK tovarna farmacevtskih in kemi�nih izdelkov d.d. | Priprava amorfnega atorvastatina |
-
1999
- 1999-05-25 IN IN775DE1999 patent/IN191236B/en unknown
-
2000
- 2000-01-06 AU AU19967/00A patent/AU778962B2/en not_active Ceased
- 2000-01-06 WO PCT/IB2000/000014 patent/WO2000071116A1/en active IP Right Grant
- 2000-01-06 AT AT00900300T patent/ATE362759T1/de active
- 2000-01-06 DE DE60034946T patent/DE60034946T2/de not_active Expired - Lifetime
- 2000-01-06 US US09/979,475 patent/US6528660B1/en not_active Expired - Lifetime
- 2000-01-06 ES ES00900300T patent/ES2284472T3/es not_active Expired - Lifetime
- 2000-01-06 BR BR0010923-1A patent/BR0010923A/pt not_active IP Right Cessation
- 2000-01-06 CN CNB008080275A patent/CN1196679C/zh not_active Expired - Fee Related
- 2000-01-06 DK DK00900300T patent/DK1185264T3/da active
- 2000-01-06 EP EP00900300A patent/EP1185264B1/en not_active Expired - Lifetime
- 2000-01-06 CN CNA2005100525833A patent/CN1680315A/zh active Pending
- 2000-01-06 PT PT00900300T patent/PT1185264E/pt unknown
- 2000-05-24 MY MYPI20002283A patent/MY133511A/en unknown
-
2001
- 2001-11-23 ZA ZA200109656A patent/ZA200109656B/en unknown
-
2002
- 2002-09-12 HK HK02106699.9A patent/HK1045118A1/zh unknown
-
2003
- 2003-03-03 US US10/378,574 patent/US20030149279A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU1996700A (en) | 2000-12-12 |
PT1185264E (pt) | 2007-07-10 |
DK1185264T3 (da) | 2007-08-20 |
WO2000071116A1 (en) | 2000-11-30 |
US6528660B1 (en) | 2003-03-04 |
US20030149279A1 (en) | 2003-08-07 |
CN1351493A (zh) | 2002-05-29 |
HK1045118A1 (zh) | 2002-11-15 |
EP1185264B1 (en) | 2007-05-23 |
DE60034946T2 (de) | 2008-01-17 |
AU778962B2 (en) | 2004-12-23 |
BR0010923A (pt) | 2002-07-16 |
CN1196679C (zh) | 2005-04-13 |
ES2284472T3 (es) | 2007-11-16 |
MY133511A (en) | 2007-11-30 |
ZA200109656B (en) | 2002-06-27 |
DE60034946D1 (de) | 2007-07-05 |
CN1680315A (zh) | 2005-10-12 |
EP1185264A1 (en) | 2002-03-13 |
ATE362759T1 (de) | 2007-06-15 |