MX339926B - (20r, 25s)-metilen-19,26-dinor-1a,25-dihidroxivitamina d3 en forma cristalina. - Google Patents

(20r, 25s)-metilen-19,26-dinor-1a,25-dihidroxivitamina d3 en forma cristalina.

Info

Publication number
MX339926B
MX339926B MX2013003375A MX2013003375A MX339926B MX 339926 B MX339926 B MX 339926B MX 2013003375 A MX2013003375 A MX 2013003375A MX 2013003375 A MX2013003375 A MX 2013003375A MX 339926 B MX339926 B MX 339926B
Authority
MX
Mexico
Prior art keywords
dinor
dihydroxyvitamin
methylene
crystalline form
solvent
Prior art date
Application number
MX2013003375A
Other languages
English (en)
Other versions
MX2013003375A (es
Inventor
F Deluca Hector
B Thoden James
Grzywacz Pawel
Holden Hazel
Original Assignee
Wisconsin Alumni Res Found *
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found * filed Critical Wisconsin Alumni Res Found *
Publication of MX2013003375A publication Critical patent/MX2013003375A/es
Publication of MX339926B publication Critical patent/MX339926B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un método para purificar (20R,25S)-2-metilen-19,26-dinor-1a,25-dih idroxivitamina D3 para obtener (20R,25S)-2-metilen-19,26-dinor-1a, 25-dihidroxivitamina D3 en forma cristalina. El método incluye las etapas de preparar un solvente de metanol y agua, disolver un producto que contiene (20R,25S)-2-metilen-19,26-dinor-1a,25-dihidr oxivitamina D3 para purificarse en el solvente, enfriar el solvente y él producto disuelto debajo de temperatura ambiente durante una cantidad suficiente de tiempo para formar un precipitado de los cristales de (20R,25S)-2-metilen-19,26-dinor-1a ,25-dihidroxivitamina D3, y recuperar los cristales de (20R,25S)-2-metilen-19,26-dinor-1a,25-dihidroxivitamina D3.
MX2013003375A 2010-09-30 2011-09-28 (20r, 25s)-metilen-19,26-dinor-1a,25-dihidroxivitamina d3 en forma cristalina. MX339926B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38853610P 2010-09-30 2010-09-30
PCT/US2011/053693 WO2012044689A1 (en) 2010-09-30 2011-09-28 (20R,25S)-2-METHYLENE-19,26-DINOR-1α, 25-DIHYDROXYVITAMIN D3 IN CRYSTALLINE FORM

Publications (2)

Publication Number Publication Date
MX2013003375A MX2013003375A (es) 2013-05-01
MX339926B true MX339926B (es) 2016-06-16

Family

ID=44906365

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013003375A MX339926B (es) 2010-09-30 2011-09-28 (20r, 25s)-metilen-19,26-dinor-1a,25-dihidroxivitamina d3 en forma cristalina.

Country Status (8)

Country Link
US (1) US8404874B2 (es)
EP (1) EP2630121A1 (es)
JP (1) JP2013540764A (es)
AU (1) AU2011308911B2 (es)
CA (1) CA2805292A1 (es)
MX (1) MX339926B (es)
NZ (1) NZ606180A (es)
WO (1) WO2012044689A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6329901B2 (ja) * 2011-08-30 2018-05-23 ウイスコンシン アラムニ リサーチ ファンデーション １α−ヒドロキシ−２０−メチル−２−メチレン−１９，２４，２５，２６，２７−ペンタノルビタミンＤ３の結晶化
EP2746252A1 (en) * 2012-12-21 2014-06-25 Wisconsin Alumni Research Foundation (WARF) Crystallization of 1alpha-hydroxy-2-methylene- 18,19-dinor-homopregnacalciferol
AU2012268858B2 (en) * 2012-12-21 2017-03-09 Wisconsin Alumni Research Foundation Crystallization of 1a-hydroxy-2-methylene-18,19-dinor-homopregnacalciferol
EP3697757A1 (en) 2017-10-17 2020-08-26 Wisconsin Alumni Research Foundation Proceduce for crystallization of (22e)-(24r)-2-methylene-22-dehydro-1a,24-25-trihydroxy-19-nor-vitamin d3

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5086191A (en) 1991-05-28 1992-02-04 Wisconsin Alumni Research Foundation Intermediates for the synthesis of 19-nor vitamin D compounds
DE69400495T2 (de) 1993-04-05 1997-04-30 Wisconsin Alumni Res Found 19-Nor-vitamin-D3-Verbindung mit einem Substituent an die 2. Stelle
SI1148049T1 (en) * 1995-07-17 2005-02-28 Warner-Lambert Company Crystalline R-(R*,R*)$-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4- (phenylamino)carbonyl -1H-pyrrole-1-heptanoic acid hemi calcium salt (atorvastatin)
US5843928A (en) 1997-03-17 1998-12-01 Wisconsin Alumni Research Foundation 2-alkylidene-19-nor-vitamin D compounds
US6673372B1 (en) * 1998-06-11 2004-01-06 Bristol-Myers Squibb Pharma Company Crystalline Efavirenz
US20040072886A1 (en) * 2002-04-15 2004-04-15 Dr. Reddy's Laboratories Limited Novel crystalline forms of (S)-N- (1-Carboxy-2-methyl-prop-1-yl) -N-pentanoyl-N- [2' -(1H-tetrazol-5-yl)- biphenyl-4-yl methyl] amine (Valsartan)
CA2489991A1 (en) * 2002-06-21 2003-12-31 Dr. Reddy's Laboratories Limited Amorphous form of(-)-}2-}4-}(4-chlorophenyl)-phenyl methyl}-1-piperazinyl|ethoxy| acetic acid dihydrochloride (levocetririzine dihydrochloride)
CA2393720C (en) * 2002-07-12 2010-09-14 Eli Lilly And Company Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
WO2007042799A1 (en) * 2005-10-10 2007-04-19 Cipla Limited Novel crystalline forms
US7528122B2 (en) 2006-02-02 2009-05-05 Wisconsin Alumni Research Foundation Vitamin D analog—NEL, methods and uses thereof
US7803789B2 (en) * 2006-02-02 2010-09-28 Wisconsin Alumni Research Foundation Vitamin D analog—RAK, methods and uses thereof
AU2008345085A1 (en) * 2007-12-28 2009-07-09 Wisconsin Alumni Research Foundation 2-methylene-(20S,25S)-19,26-dinor-vitamin D analogs
AU2008345084A1 (en) * 2007-12-28 2009-07-09 Wisconsin Alumni Research Foundation 2-methylene-(20S,25R)-19,26-dinor-vitamin D analogs

Also Published As

Publication number Publication date
WO2012044689A1 (en) 2012-04-05
MX2013003375A (es) 2013-05-01
CA2805292A1 (en) 2012-04-05
US20120083614A1 (en) 2012-04-05
NZ606180A (en) 2014-10-31
AU2011308911B2 (en) 2014-10-02
JP2013540764A (ja) 2013-11-07
EP2630121A1 (en) 2013-08-28
US8404874B2 (en) 2013-03-26
AU2011308911A1 (en) 2013-01-31

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