TR200505120T2 - Antimikrobiyal kuinolonlar, bunların bileşimleri ve kullanımları. - Google Patents

Antimikrobiyal kuinolonlar, bunların bileşimleri ve kullanımları.

Info

Publication number
TR200505120T2
TR200505120T2 TR2005/05120T TR200505120T TR200505120T2 TR 200505120 T2 TR200505120 T2 TR 200505120T2 TR 2005/05120 T TR2005/05120 T TR 2005/05120T TR 200505120 T TR200505120 T TR 200505120T TR 200505120 T2 TR200505120 T2 TR 200505120T2
Authority
TR
Turkey
Prior art keywords
compounds
compositions
antimicrobial quinolones
antimicrobial
quinolones
Prior art date
Application number
TR2005/05120T
Other languages
English (en)
Inventor
Ledoussal Benoit
Kim Almstead Ji-In
Lyle Gray Jeffrey
Eric Hu Xiufeng
Original Assignee
The Procter & Gamble Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Procter & Gamble Company filed Critical The Procter & Gamble Company
Publication of TR200505120T2 publication Critical patent/TR200505120T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

Söz konusu buluş, içinde X, R1, R3, R5, R6 ve R8'in istemlerde belirtildiği şekilde olduğu formül (l)'e uygun yeni antimikrobiyal terkipler bunların optik izomerleri, diastereomerleri ya da enantiomerleri ve farmasötik olarak kabul edilir tuzlan, hidratları ve biyolojik olarak hidrolize olabilir esterleri, amidleri ve imidleri ve bileşimleri ve bugibi terkiplerin kullanımları ile ilgilidir. Buluş aynca bu terkiplerden türetilen ve antimikrobiyal olarak kullanılan terkiplerle ilgilidir.
TR2005/05120T 1997-09-15 1998-09-15 Antimikrobiyal kuinolonlar, bunların bileşimleri ve kullanımları. TR200505120T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5889197P 1997-09-15 1997-09-15
US13985998A 1998-08-25 1998-08-25

Publications (1)

Publication Number Publication Date
TR200505120T2 true TR200505120T2 (tr) 2006-08-21

Family

ID=26738133

Family Applications (2)

Application Number Title Priority Date Filing Date
TR2000/01435T TR200001435T2 (tr) 1997-09-15 1998-09-15 Antimikrobiyal kuinolonlar, bunların bileşimleri ve kullanımları
TR2005/05120T TR200505120T2 (tr) 1997-09-15 1998-09-15 Antimikrobiyal kuinolonlar, bunların bileşimleri ve kullanımları.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
TR2000/01435T TR200001435T2 (tr) 1997-09-15 1998-09-15 Antimikrobiyal kuinolonlar, bunların bileşimleri ve kullanımları

Country Status (31)

Country Link
US (3) US6329391B1 (tr)
EP (1) EP1015445B1 (tr)
JP (1) JP4669607B2 (tr)
KR (1) KR100423778B1 (tr)
CN (1) CN1264837C (tr)
AR (1) AR013493A1 (tr)
AT (1) ATE423776T1 (tr)
AU (1) AU735186B2 (tr)
BR (1) BR9812644B1 (tr)
CA (1) CA2303389C (tr)
CO (1) CO4970702A1 (tr)
CY (1) CY1110255T1 (tr)
CZ (1) CZ299554B6 (tr)
DE (1) DE69840599D1 (tr)
DK (1) DK1015445T3 (tr)
ES (1) ES2321042T3 (tr)
HK (1) HK1030415A1 (tr)
HU (1) HUP0100051A3 (tr)
ID (1) ID24703A (tr)
IL (2) IL135036A0 (tr)
MY (1) MY138335A (tr)
NO (1) NO323563B1 (tr)
NZ (1) NZ503740A (tr)
PE (1) PE128799A1 (tr)
PL (1) PL339408A1 (tr)
PT (1) PT1015445E (tr)
RU (1) RU2193558C2 (tr)
SA (1) SA99191136B1 (tr)
SK (1) SK286420B6 (tr)
TR (2) TR200001435T2 (tr)
WO (1) WO1999014214A1 (tr)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6387928B1 (en) 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
ID24703A (id) * 1997-09-15 2000-08-03 Procter & Gamble Kuinolon antimikroba, komposisi dan penggunaannya
DE69925859T2 (de) * 1998-11-24 2006-05-11 Daiichi Pharmaceutical Co., Ltd. Cycloalkylsubstituierte aminomethylpyrrolidin-derivate
WO2000068229A2 (en) * 1999-05-07 2000-11-16 Wockhardt Limited (s)-benzoquinolizine carboxylic acids and their use as antibacterial agents
US6750224B1 (en) 1999-05-07 2004-06-15 Wockhardt Limited Antibacterial optically pure benzoquinolizine carboxylic acids, processes, compositions and methods of treatment
US6514986B2 (en) 2000-11-22 2003-02-04 Wockhardt Limited Chiral fluoroquinolone arginine salt forms
US6608078B2 (en) 2000-05-08 2003-08-19 Wockhardt Limited Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment
US7098219B2 (en) 2000-08-01 2006-08-29 Wockhart Limited Inhibitors of cellular efflux pumps of microbes
IL155976A0 (en) * 2000-11-20 2003-12-23 Daiichi Seiyaku Co Dehalogeno compounds
AU2002230891B2 (en) * 2000-12-14 2005-04-07 The Procter & Gamble Company Antimicrobial quinolones
US6964966B2 (en) 2001-04-25 2005-11-15 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6878713B2 (en) 2001-04-25 2005-04-12 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
WO2003099815A1 (en) 2002-05-28 2003-12-04 Wockhardt Limited Crystalline fluoroquinolone arginine salt form
US6900224B2 (en) * 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
RS20050380A (en) 2002-11-21 2007-11-15 Pfizer Products Inc., 3-amino piperidine derivatives and methods of manufacture
PT1567117E (pt) 2002-11-26 2012-05-09 Univ Chicago Prevenção e tratamento de distúrbios epiteliais mediados por micróbios
EP1632482A4 (en) * 2003-06-06 2009-10-28 Daiichi Seiyaku Co INTERMEDIATES AND PROCESS FOR THE PRODUCTION OF OPTICALLY ACTIVE QUINOLONECARBOXYLIC ACID DERIVATIVES
DK1660495T3 (da) 2003-09-04 2007-11-05 Wockhardt Ltd Benzoquinolizin-2-carboxylsyreargininsalt,tetrahydrat
DE10341534A1 (de) * 2003-09-09 2005-03-31 Bayer Chemicals Ag Difluoralkylaromaten
PT1666477E (pt) * 2003-09-10 2013-08-28 Kyorin Seiyaku Kk Derivado de 7-(4-substituído-3-ciclopropilaminometil-1- pirrolidinil) quinolonecarboxílico
ES2321722T3 (es) * 2003-09-22 2009-06-10 Janssen Pharmaceutica Nv Naftiridonas y quinolonas 7-amino alquilidenil-heterociclicas.
CN1980670A (zh) * 2004-07-02 2007-06-13 第一制药株式会社 含有喹诺酮的医药组合物
US7732612B2 (en) * 2004-09-09 2010-06-08 Janssen Pharmaceutica, N.V. 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
US20090156577A1 (en) * 2004-09-09 2009-06-18 Benjamin Davis 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
DE102006010643A1 (de) * 2006-03-08 2007-09-13 Bayer Healthcare Aktiengesellschaft Arzneimittel enthaltend Fluorchinolone
US7456279B2 (en) 2006-03-28 2008-11-25 The Procter & Gamble Company Coupling process for preparing quinolone intermediates
CN101045725B (zh) * 2006-03-28 2012-12-05 太景生物科技股份有限公司 某些喹诺酮化合物的苹果酸盐和多晶型物
BRPI0709772B8 (pt) * 2006-03-28 2021-05-25 The Protecter & Gamble Company sais de malato e polimorfos do ácido (3s,5s)-7-[3-amino-5-metil-piperidinil]-1-ciclopropil-1,4-diidro-8-metóxi-4-oxo-3-quinolinocarboxílico
CA2647457C (en) 2006-03-28 2011-05-24 The Procter & Gamble Company A hydride reduction process for preparing quinolone intermediates
TW200811153A (en) 2006-06-23 2008-03-01 Japan Tobacco Inc 6-(heterocyclyl-substituted benzyl)-4-oxoquinoline compound and use thereof as HIV integrase inhibitor
EP2149571A4 (en) * 2007-05-24 2010-09-01 Kyorin Seiyaku Kk MUTILINE DERIVATIVE WITH A RINGED, HETEROCYCLIC AND AROMATIC CARBOXYLIC ACID STRUCTURE IN A SUBSTITUTE AT POSITION 14
US7902227B2 (en) 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
US8658183B2 (en) * 2007-08-09 2014-02-25 Taigen Biotechnology Company, Ltd. Antimicrobial parenteral formulation
CN101361739B (zh) * 2007-08-09 2012-03-14 太景生物科技股份有限公司 抗菌剂的肠胃外制剂
KR20150006080A (ko) * 2008-07-01 2015-01-15 타이젠 바이오테크놀러지 컴퍼니 리미티드 항생제 내성 세균 감염의 치료
CN101618039B (zh) * 2008-07-02 2012-04-11 太景生物科技股份有限公司 肺炎的治疗药物
US20120157492A1 (en) * 2008-07-15 2012-06-21 Taigen Biotechnology Co., Ltd. Antibiotic drug
FR2936798B1 (fr) * 2008-10-03 2012-09-28 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens.
FR2937034B1 (fr) * 2008-10-10 2012-11-23 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens
FR2936951B1 (fr) * 2008-10-10 2010-12-03 Novexel Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments
WO2010077798A2 (en) * 2008-12-15 2010-07-08 Taigen Biotechnology Co., Ltd. Stereoselective synthesis of piperidine derivatives
BR112012009583A2 (pt) * 2009-10-23 2015-09-29 Vertex Pharma processo para preparação de moduladores de regulador de condutância de transmembrana de fibrose cística
TW201206889A (en) * 2010-05-11 2012-02-16 Sanofi Aventis Substituted N-alkyl and N-acyl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof
CN102746223B (zh) * 2012-07-30 2013-10-23 浙江新东港药业股份有限公司 一种氟哌酸与氯哌酸的分离方法
CN103819401B (zh) * 2012-11-19 2016-04-13 浙江中欣氟材股份有限公司 1-环丙基-4-氧代-7-氟-8-甲氧基-1,4-二氢喹啉-3-羧酸的合成方法
US20160326165A1 (en) 2013-12-26 2016-11-10 Kinki University Alkoxycarbonyl hemiacetal-type ester prodrug of pyridone carboxylic acid antibacterial drug
RU2636751C1 (ru) 2016-11-02 2017-12-01 федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) Антибактериальные средства на основе производных ципрофлоксацина
CN114008031A (zh) 2019-10-23 2022-02-01 太景生物科技股份有限公司 喹诺酮羧酸衍生物

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4017622A (en) 1972-12-18 1977-04-12 Dainippon Pharmaceutical Co., Ltd. Piperazine derivatives
JPS5186476A (en) 1975-01-17 1976-07-29 Yoshitomi Pharmaceutical Shinkina kinoronkarubonsanjudotaino seiho
JPS5845426B2 (ja) 1978-09-29 1983-10-08 杏林製薬株式会社 置換キノリンカルボン酸誘導体
JPS604820B2 (ja) 1979-02-26 1985-02-06 大塚製薬株式会社 キノリンカルボン酸誘導体
JPS5649382A (en) 1979-09-28 1981-05-02 Dainippon Pharmaceut Co Ltd 6-fluoro-7-cyclic amino-1,8-naphthylidine derivative and its salt
US5281612A (en) 1982-09-09 1994-01-25 Warner-Lambert Company Naphthyridine antibacterial agents
US4665079A (en) 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
IE55898B1 (en) 1982-09-09 1991-02-14 Warner Lambert Co Antibacterial agents
DE3248506A1 (de) 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4994599A (en) 1987-11-20 1991-02-19 Abbott Laboratories Intermediates for producing quinolone-3-carboxylic acids
JPS60221484A (ja) * 1984-04-17 1985-11-06 Fuji Photo Film Co Ltd 放射線像変換方法およびその方法に用いられる放射線像変換パネル
US4822801A (en) 1984-07-20 1989-04-18 Warner-Lambert Company 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents
US4771054A (en) 1985-01-23 1988-09-13 Warner-Lambert Company Antibacterial agents
JPS61205258A (ja) 1985-03-08 1986-09-11 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体及びその製造方法
AU5427286A (en) 1985-03-08 1986-09-11 Kyorin Pharmaceutical Co. Ltd. 7-(1-pyrrolidinyl)-3-quinolinecarboxylic acid derivatives
JPS61225181A (ja) * 1986-02-04 1986-10-06 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体及びその製造方法
DE3685157D1 (de) 1985-06-26 1992-06-11 Daiichi Seiyaku Co Pyridoncarbonsaeurederivate.
JPS6236377A (ja) * 1985-07-03 1987-02-17 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
DE3524411A1 (de) * 1985-07-09 1987-01-15 Kernforschungsz Karlsruhe Verfahren zum herstellen von spinnduesenplatten
JPS6256673A (ja) 1985-09-03 1987-03-12 Kayaba Ind Co Ltd カウンタ−バランス弁の制御装置
JPH089597B2 (ja) * 1986-01-21 1996-01-31 杏林製薬株式会社 選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法
DE3705621C2 (de) 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
JPS62205060A (ja) * 1986-03-04 1987-09-09 Kyorin Pharmaceut Co Ltd ８位置換キノロンカルボン酸誘導体
JPS62215572A (ja) 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
JPS63198664A (ja) 1986-03-31 1988-08-17 Sankyo Co Ltd キノロンカルボン酸誘導体
JPH0717608B2 (ja) 1986-04-25 1995-03-01 杏林製薬株式会社 ６−アルコキシキノロンカルボン酸誘導体
DE3704907A1 (de) 1987-02-17 1988-08-25 Bayer Ag Topisch anwendbare zubereitungen von gyrase-inhibitoren in kombination mit kortikosteroiden
JPS6416767A (en) 1987-07-09 1989-01-20 Dainippon Pharmaceutical Co 8-halogenoquinoline derivative, its ester and salt
JPS6416767U (tr) 1987-07-20 1989-01-27
JP2608413B2 (ja) 1987-07-26 1997-05-07 本多電子株式会社 超音波駆動装置
US4780468A (en) 1987-08-07 1988-10-25 Warner-Lambert Company 8-trifluoromethyl quinolones as antibacterial agents
US4921857A (en) 1987-09-18 1990-05-01 Merck & Co., Inc. 4-Oxo-4h-quinolizine-3-carboxylic acids and derivatives thereof
US4920120A (en) 1988-01-25 1990-04-24 Warner-Lambert Company Antibacterial agents
DE68920773T2 (de) * 1988-05-19 1995-05-18 Chugai Pharmaceutical Co Ltd Chinoloncarbonsäure-Derivate.
JP2844079B2 (ja) 1988-05-23 1999-01-06 塩野義製薬株式会社 ピリドンカルボン酸系抗菌剤
DE3906365A1 (de) 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
AU618823B2 (en) 1988-07-20 1992-01-09 Sankyo Company Limited 4-oxoquinoline-3-carboxylic acid derivatives, their preparation and their use
US5286723A (en) 1988-08-31 1994-02-15 Daiichi Seiyaku Co., Ltd. Spiro compound
CA2001203C (en) 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Novel antimicrobial dithiocarbamoyl quinolones
US5328908A (en) 1988-10-24 1994-07-12 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolone thioureas
EP0366189A3 (en) 1988-10-24 1992-01-02 Norwich Eaton Pharmaceuticals, Inc. Novel antimicrobial lactam-quinolones
RU2049777C1 (ru) 1989-08-16 1995-12-10 Пфайзер Инк. Азабицикло-хинолон-карбоновые кислоты или их фармацевтически приемлемые кислотно-аддитивные соли и промежуточные продукты для их получения
US5164402A (en) 1989-08-16 1992-11-17 Pfizer Inc Azabicyclo quinolone and naphthyridinone carboxylic acids
JPH03115277A (ja) 1989-09-28 1991-05-16 Banyu Pharmaceut Co Ltd ピリドンカルボン酸誘導体
CN1054980A (zh) * 1990-02-19 1991-10-02 杏林制药株式会社 具有旋光活性的8-甲氧基喹诺酮羧酸衍生物，它们的制备方法以及它们的中间体
JPH03244733A (ja) 1990-02-21 1991-10-31 Shimizu Corp 外壁の接続構造
US5116834A (en) 1990-04-12 1992-05-26 Warner-Lambert Company Quinolinecarboxylic acid antibacterial agents
EP0527889B1 (en) 1990-05-02 2000-08-02 Abbott Laboratories Quinolizinone type compounds
US5599816A (en) 1990-05-02 1997-02-04 Abbott Laboratories Quinolizinone type compounds
US5580872A (en) 1990-05-02 1996-12-03 Abbott Laboratories Quinolizinone type compounds
CS567590A3 (en) * 1990-11-16 1992-06-17 Vyzk Ustav Farm Biochem Sp Fluoroquinolone derivatives having in the position 7 4-piperidone radical or modifications thereof
US5364861A (en) 1990-11-30 1994-11-15 Warner-Lambert Company Optical isomers of 7-[3-(1,1-dialkylmethyl-1-amino-1-pyrrolidinyl]-quinolones and naphthyridones as antibacterial agents
US5072001A (en) 1990-11-30 1991-12-10 Warner-Lambert Company Certain optically active substituted 3-pyrraidine acetic acid derivatives useful as intermediates
US5258528A (en) 1990-11-30 1993-11-02 Warner-Lambert Company Individual stereoisomers of pyrrolidine methanamines substituted on the ring nitrogen by a 1-phenylethyl group
JPH04265511A (ja) 1991-02-19 1992-09-21 Sony Corp 磁気記録媒体
DE4120646A1 (de) * 1991-06-22 1992-12-24 Bayer Ag 7-isoindolinyl-chinolon- und naphthyridoncarbonsaeure-derivate
DE4123918A1 (de) 1991-07-19 1993-01-21 Bayer Ag 8-vinyl- und 8-ethinyl-chinoloncarbonsaeuren
KR930703292A (ko) 1991-12-27 1993-11-29 쿠사이 요시히로 신규 퀴놀론 유도체 또는 그의 염 및 이 화합물을 함유하는 항균제
EP0550016A1 (en) * 1991-12-31 1993-07-07 Korea Research Institute Of Chemical Technology Novel quinolone carboxylic acid derivatives and processes for preparing same
JPH05112554A (ja) 1992-02-19 1993-05-07 Chugai Pharmaceut Co Ltd 新規なキノロンカルボン酸誘導体
JPH05345777A (ja) 1992-04-16 1993-12-27 Hokuriku Seiyaku Co Ltd ７−（４，４−ジアルキル−３−アミノ置換ピロリジニル）キノロン−３−カルボン酸誘導体
NO304832B1 (no) 1992-05-27 1999-02-22 Ube Industries Aminokinolonderivater samt middel mot HIV
DE4230804A1 (de) 1992-09-15 1994-03-17 Bayer Ag 7-Isoindolinyl-chinolon- und -naphthyridon-Derivate
DE4234078A1 (de) 1992-10-09 1994-04-14 Bayer Ag Chinoloncarbonsäuren
KR0148277B1 (ko) 1993-01-18 1998-11-02 채영복 신규한 플루오르퀴놀론계 유도체 및 그의 제조방법
DE4301246A1 (de) 1993-01-19 1994-07-21 Bayer Ag Chinolon- und Naphthyridoncarbonsäurederivate
DE4301245A1 (de) 1993-01-19 1994-07-21 Bayer Ag Fluor-trifluormethylbenzoesäure-Derivate
CA2152828A1 (en) 1993-03-16 1994-07-07 Shin-Ichi Uesato 8-methoxy-quinolonecarboxylic acid derivatives
TW252107B (tr) * 1993-08-27 1995-07-21 Hokuriku Pharmacetical Co Ltd
AU689809B2 (en) 1993-10-14 1998-04-09 Abbott Laboratories Quinolizinone type compounds
JPH0780847B2 (ja) 1994-03-24 1995-08-30 大日本製薬株式会社 ビシクロアミン誘導体
KR100371723B1 (ko) 1994-08-12 2003-03-15 도야마 가가쿠 고교 가부시키가이샤 신규한퀴놀론-또는나프틸리돈-카복실산유도체또는그의염
JP3745433B2 (ja) 1995-02-02 2006-02-15 第一製薬株式会社 複素環式化合物
ES2315432T3 (es) 1995-02-02 2009-04-01 Daiichi Sankyo Company, Limited Derivados de acido piridonacarboxilico y su uso como agentes antibacterianos.
CA2212226A1 (en) 1995-02-02 1995-08-10 Katsumi Chiba Bicyclic amino group-substituted pyridonecarboxylic acid derivatives, esters thereof and salts thereof, and bicyclic amines useful as intermediates thereof
DE19512484A1 (de) 1995-04-04 1996-10-17 Bayer Ag Kohlenhydratmodifizierte Cytostatika
IL122296A0 (en) 1995-06-06 1998-04-05 Abbott Lab Quinolizinone type compounds
JPH092953A (ja) 1995-06-16 1997-01-07 Chugai Pharmaceut Co Ltd バルフロキサシン製剤
IT1279532B1 (it) 1995-07-24 1997-12-16 Mediolanum Farmaceutici Spa Derivati chinolonici non fluorurati e loro impiego come agenti antibatterici
JPH0952893A (ja) 1995-08-10 1997-02-25 Yoshitomi Pharmaceut Ind Ltd キノロンカルボン酸誘導体の工業的な製造法およびその合成中間体
JP3833738B2 (ja) 1995-11-15 2006-10-18 第一製薬株式会社 置換アミノメチルピロリジン誘導体
DE69635812T2 (de) 1995-11-22 2006-10-19 Daiichi Pharmaceutical Co., Ltd. Substituierte aminocycloalkylpyrrolidinderivate
JP2697720B2 (ja) 1995-12-27 1998-01-14 日本電気株式会社 ポラリメトリ合成開口レーダ装置
ES2188890T3 (es) 1996-02-09 2003-07-01 Toyama Chemical Co Ltd Derivados del acido quinoleincarboxilico y sus sales.
JPH09240318A (ja) 1996-03-07 1997-09-16 Mitsubishi Motors Corp インストルメントパネル取付け構造
JPH09287669A (ja) 1996-04-23 1997-11-04 Toshiba Corp 弁装置
WO1998018783A1 (fr) 1996-10-25 1998-05-07 Daiichi Pharmaceutical Co., Ltd. Derives d'amine tricycliques
US6274592B1 (en) 1997-02-04 2001-08-14 Senju Pharmaceutical Co., Ltd. Method for stabilizing arylcarboxylic acid, stabilizer thereof and aqueous solution containing stabilized arylcarboxylic acid
CA2289605A1 (en) 1997-05-21 1998-11-26 Daiichi Pharmaceutical Co., Ltd. Cis-substituted substituted aminocycloalkylpyrrolidine derivatives
MY119816A (en) 1997-05-30 2005-07-29 Daiichi Seiyaku Co Substituted cyclobutylamine derivatives
KR100241673B1 (ko) 1997-08-09 2000-03-02 김충섭 퀴놀리진 카르복실산 유도체
ID24703A (id) 1997-09-15 2000-08-03 Procter & Gamble Kuinolon antimikroba, komposisi dan penggunaannya
US6387928B1 (en) * 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
GB9822440D0 (en) 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
GB9914486D0 (en) 1999-06-21 1999-08-18 Smithkline Beecham Plc Medicaments
IL150393A0 (en) 2000-01-24 2002-12-01 Warner Lambert Co 3-aminoquinazolin-2,4-dione antibacterial agents
AU2002230891B2 (en) * 2000-12-14 2005-04-07 The Procter & Gamble Company Antimicrobial quinolones
US6900224B2 (en) * 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses

Also Published As

Publication number Publication date
ATE423776T1 (de) 2009-03-15
EP1015445B1 (en) 2009-02-25
CA2303389C (en) 2007-07-17
ES2321042T3 (es) 2009-06-01
US7868021B2 (en) 2011-01-11
US6329391B1 (en) 2001-12-11
NZ503740A (en) 2002-09-27
JP4669607B2 (ja) 2011-04-13
IL135036A0 (en) 2001-05-20
TR200001435T2 (tr) 2000-08-21
NO20001340D0 (no) 2000-03-15
US20090111851A1 (en) 2009-04-30
SK286420B6 (sk) 2008-09-05
EP1015445A1 (en) 2000-07-05
WO1999014214A1 (en) 1999-03-25
CN1278813A (zh) 2001-01-03
NO20001340L (no) 2000-05-15
HUP0100051A3 (en) 2002-08-28
AR013493A1 (es) 2000-12-27
CZ299554B6 (cs) 2008-09-03
MY138335A (en) 2009-05-29
SA99191136B1 (ar) 2006-07-30
AU735186B2 (en) 2001-07-05
SK3812000A3 (en) 2000-09-12
KR20010024007A (ko) 2001-03-26
DK1015445T3 (da) 2009-05-11
ID24703A (id) 2000-08-03
NO323563B1 (no) 2007-06-11
PT1015445E (pt) 2009-05-14
BR9812644A (pt) 2001-12-18
CO4970702A1 (es) 2000-11-07
RU2193558C2 (ru) 2002-11-27
CN1264837C (zh) 2006-07-19
JP2001516756A (ja) 2001-10-02
BR9812644B1 (pt) 2010-07-13
US7482454B2 (en) 2009-01-27
US20060100436A1 (en) 2006-05-11
HUP0100051A2 (hu) 2001-10-28
CZ2000931A3 (cs) 2000-08-16
CY1110255T1 (el) 2015-01-14
HK1030415A1 (en) 2001-05-04
DE69840599D1 (de) 2009-04-09
IL135036A (en) 2007-12-03
PE128799A1 (es) 2000-02-17
CA2303389A1 (en) 1999-03-25
KR100423778B1 (ko) 2004-03-24
AU9482998A (en) 1999-04-05
PL339408A1 (en) 2000-12-18

Similar Documents

Publication Publication Date Title
TR200505120T2 (tr) Antimikrobiyal kuinolonlar, bunların bileşimleri ve kullanımları.
HUT67144A (en) Piperazinyl-and piperidinyl-cyclohexanols and pharraceutical compositions comprising them
MEP24608A (en) Azetidine derivatives, preparation thereof and pharmaceutical compositions containing same
ZA200309887B (en) Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents.
BR1100086A (pt) Derivados de fluoralcóxibenzilamino de heterocìclos contendo nitrogênio
NO991974D0 (no) 5-HT1F agonister
IL99775A0 (en) Antimicrobial agents containing substituted 2-cyclohexan-1-yl-amino derivatives,certain such novel compounds and their preparation
NO934718D0 (no) Nye HIV protease inhibitorer
TR199902883T2 (tr) NK-2 ve NK-3 reseptör antagonistleri olarak kuinolin-4-karboksamid türevleri.
DK0775114T3 (da) Fremgangsmåde til fremstilling af antimikrobielle forbindelser
ZW9791A1 (en) New heterocyclic chemistry
DK1089625T3 (da) Ektoparasiticide midler
ATE240299T1 (de) Diester prodrugs von decahydroischinoline-3- carbonsäure
FI960658A (fi) Uudet bis-naftalimidit syövän hoitamiseksi
DE60225155D1 (de) 3-substituierte 6,7-dihydroxytetrahydroisochinolin-derivate zur verwendung als antibkaterielle mittel
DE69600244D1 (de) Basische prolinamid derivate von ge2270 und ge2270-ahnlichten antibiotika
ES2104174T3 (es) Derivados de bencilamino, bencilamido y bencilimido ciclicos utilizados como agentes antipsicoticos.
ES2181790T3 (es) Compuestos azaciclohexapeptidicos.
CA2281702A1 (en) (4-piperidinyl)-1h-2-benzopyran derivatives useful as antipsychotic agents
EP0226624A1 (en) Cyclopentapyrazole and tetrahydroindazole compounds
BR9910370A (pt) Compostos de cefalosporina, processo para preparar compostos de cefalosporina, e, composições antimicrobianas
SE9902147L (sv) Nya föreningar och farmaceutiska kompositioner innehållande desamma
PT1140932E (pt) Derivados de 1,8-benzonaftiridina