SK287401B6 - Deriváty chinazolínu, spôsob ich prípravy, farmaceutická kompozícia, ktorá ich obsahuje, a ich použitie - Google Patents

Info

Publication number

SK287401B6

SK287401B6 SK612-2002A SK6122002A SK287401B6 SK 287401 B6 SK287401 B6 SK 287401B6 SK 6122002 A SK6122002 A SK 6122002A SK 287401 B6 SK287401 B6 SK 287401B6

Authority

SK

Slovakia

Prior art keywords

formula

quinazoline

ylmethoxy

methoxy

compound

Prior art date

1999-11-05

Links

• Espacenet
• Global Dossier
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• 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 6
• 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title abstract description 3
• 238000004519 manufacturing process Methods 0.000 title description 3
• 150000001875 compounds Chemical class 0.000 claims abstract description 173
• 150000003839 salts Chemical class 0.000 claims abstract description 78
• 238000000034 method Methods 0.000 claims abstract description 45
• 206010028980 Neoplasm Diseases 0.000 claims abstract description 31
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims abstract description 22
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims abstract description 22
• 125000000217 alkyl group Chemical group 0.000 claims abstract description 22
• 238000002360 preparation method Methods 0.000 claims abstract description 20
• 125000001424 substituent group Chemical group 0.000 claims abstract description 19
• 238000011282 treatment Methods 0.000 claims abstract description 18
• 201000010099 disease Diseases 0.000 claims abstract description 13
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 13
• 230000008569 process Effects 0.000 claims abstract description 12
• 201000011510 cancer Diseases 0.000 claims abstract description 11
• 125000003342 alkenyl group Chemical group 0.000 claims abstract description 9
• 125000000304 alkynyl group Chemical group 0.000 claims abstract description 8
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 7
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 5
• 239000004480 active ingredient Substances 0.000 claims abstract description 4
• 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims abstract 2
• -1 2-fluorofluoro-4-methylphenyl Chemical group 0.000 claims description 134
• 241001465754 Metazoa Species 0.000 claims description 21
• 125000004432 carbon atom Chemical group C* 0.000 claims description 21
• 229910052736 halogen Inorganic materials 0.000 claims description 17
• 150000002367 halogens Chemical class 0.000 claims description 17
• 239000003814 drug Substances 0.000 claims description 16
• 150000003246 quinazolines Chemical class 0.000 claims description 16
• 239000002253 acid Substances 0.000 claims description 14
• 230000033115 angiogenesis Effects 0.000 claims description 10
• 230000008728 vascular permeability Effects 0.000 claims description 10
• 125000003545 alkoxy group Chemical group 0.000 claims description 9
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
• 239000003795 chemical substances by application Substances 0.000 claims description 6
• 239000002246 antineoplastic agent Substances 0.000 claims description 5
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• 125000003386 piperidinyl group Chemical group 0.000 claims description 5
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• 125000005843 halogen group Chemical group 0.000 abstract 3
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• 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
• 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
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