SI2639224T1 - Postopek za pripravo cikloalkilkarboksiamido-piridinskih benzojskih kislin - Google Patents

Postopek za pripravo cikloalkilkarboksiamido-piridinskih benzojskih kislin

Info

Publication number
SI2639224T1
SI2639224T1 SI200831715A SI200831715A SI2639224T1 SI 2639224 T1 SI2639224 T1 SI 2639224T1 SI 200831715 A SI200831715 A SI 200831715A SI 200831715 A SI200831715 A SI 200831715A SI 2639224 T1 SI2639224 T1 SI 2639224T1
Authority
SI
Slovenia
Prior art keywords
benzoic acids
cycloalkylcarboxiamido
producing
pyridine benzoic
pyridine
Prior art date
Application number
SI200831715A
Other languages
English (en)
Inventor
David Siesel
Original Assignee
Vertex Pharmaceuticals Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Incorporated filed Critical Vertex Pharmaceuticals Incorporated
Publication of SI2639224T1 publication Critical patent/SI2639224T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/08—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
SI200831715A 2007-12-07 2008-12-04 Postopek za pripravo cikloalkilkarboksiamido-piridinskih benzojskih kislin SI2639224T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1218107P 2007-12-07 2007-12-07
US10957308P 2008-10-30 2008-10-30
EP12196539.6A EP2639224B1 (en) 2007-12-07 2008-12-04 Process for producing cycloalkylcarboxiamido-pyridine benzoic acids

Publications (1)

Publication Number Publication Date
SI2639224T1 true SI2639224T1 (sl) 2016-12-30

Family

ID=40329178

Family Applications (4)

Application Number Title Priority Date Filing Date
SI200831706A SI2639222T1 (sl) 2007-12-07 2008-12-04 Proces za izdelavo cikloalkilkarboksiamido-piridin benzojskih kislin
SI200831715A SI2639224T1 (sl) 2007-12-07 2008-12-04 Postopek za pripravo cikloalkilkarboksiamido-piridinskih benzojskih kislin
SI200831820A SI2639223T1 (sl) 2007-12-07 2008-12-04 Postopek za pripravo cikloalkilkarboksiamido-piridinskih benzojskih kislin
SI200830952T SI2231606T1 (sl) 2007-12-07 2008-12-04 Postopek proizvodnje cikloalkilkarboksamido-piridin benzojskih kislin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SI200831706A SI2639222T1 (sl) 2007-12-07 2008-12-04 Proces za izdelavo cikloalkilkarboksiamido-piridin benzojskih kislin

Family Applications After (2)

Application Number Title Priority Date Filing Date
SI200831820A SI2639223T1 (sl) 2007-12-07 2008-12-04 Postopek za pripravo cikloalkilkarboksiamido-piridinskih benzojskih kislin
SI200830952T SI2231606T1 (sl) 2007-12-07 2008-12-04 Postopek proizvodnje cikloalkilkarboksamido-piridin benzojskih kislin

Country Status (26)

Country Link
US (4) US8124781B2 (sl)
EP (4) EP2231606B1 (sl)
JP (4) JP5702149B2 (sl)
KR (3) KR20150066608A (sl)
CN (2) CN101910134B (sl)
AU (1) AU2008335440B2 (sl)
BR (1) BRPI0820902A2 (sl)
CA (3) CA3147290A1 (sl)
CL (1) CL2010000631A1 (sl)
CY (4) CY1113985T1 (sl)
DK (4) DK2639222T3 (sl)
EA (1) EA201070700A1 (sl)
ES (4) ES2604178T3 (sl)
HK (2) HK1146820A1 (sl)
HR (4) HRP20130418T1 (sl)
HU (3) HUE029775T2 (sl)
IL (4) IL206205A (sl)
LT (3) LT2639224T (sl)
MX (4) MX365732B (sl)
NZ (3) NZ612635A (sl)
PL (4) PL2639223T3 (sl)
PT (4) PT2231606E (sl)
RS (4) RS52759B (sl)
SI (4) SI2639222T1 (sl)
WO (1) WO2009076142A2 (sl)
ZA (1) ZA201003624B (sl)

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NZ624460A (en) 2009-03-20 2015-12-24 Vertex Pharma Process for making modulators of cystic fibrosis transmembrane conductance regulator
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TW202120517A (zh) 2019-08-14 2021-06-01 美商維泰克斯製藥公司 製備cftr調節劑之方法
TW202115092A (zh) 2019-08-14 2021-04-16 美商維泰克斯製藥公司 囊腫纖維化跨膜傳導調節蛋白之調節劑
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CN116601158A (zh) 2020-10-07 2023-08-15 弗特克斯药品有限公司 囊性纤维化跨膜传导调控因子的调节剂
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TW202333699A (zh) 2022-02-03 2023-09-01 美商維泰克斯製藥公司 囊腫纖維化之治療方法
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