CL2010000631A1 - Proceso para preparar la forma i del acido 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-il)ciclopropancarboxamido)-3-metilpiridin-2-il)benzoico (compuesto 1) a partir de 2-bromo-3-metilpiridina (compuesto 2) y ácido 3-(t-butoxicarbonil)fenilboronico (compuesto 3). - Google Patents
Proceso para preparar la forma i del acido 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-il)ciclopropancarboxamido)-3-metilpiridin-2-il)benzoico (compuesto 1) a partir de 2-bromo-3-metilpiridina (compuesto 2) y ácido 3-(t-butoxicarbonil)fenilboronico (compuesto 3).Info
- Publication number
- CL2010000631A1 CL2010000631A1 CL2010000631A CL2010000631A CL2010000631A1 CL 2010000631 A1 CL2010000631 A1 CL 2010000631A1 CL 2010000631 A CL2010000631 A CL 2010000631A CL 2010000631 A CL2010000631 A CL 2010000631A CL 2010000631 A1 CL2010000631 A1 CL 2010000631A1
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- Prior art keywords
- compound
- acid
- methylpyridine
- theta
- organic solvent
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/08—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Catalysts (AREA)
Abstract
UN PROCESO PARA LA PREPARACIÓN DE LA FORMA I DEL COMPUESTO 1 LA QUE POSEE UNO O MÁS DE LOS SIGUIENTES PICOS A 15,4 ±0,2°THETA, 16,3 ±0,2°THETA Y 14,5 ±0,2°THETA EN SU PATRÓN DE DIFRACCIÓN DE RAYOS X DE POLVO, DONDE EL MÉTODO COMPRENDE LOS PASOS DE: I) PROVEER 2–BROMO–3–METILPIRIDINA (COMPUESTO 2) Y ÁCIDO 3–(T–BUTOXICARBONIL)FENILBORÓNICO (COMPUESTO 3); II) ACOPLAR DE MANERA CRUZADA EL COMPUESTO 2 Y COMPUESTO 3 EN UNA MEZCLA BIFÁSICA QUE COMPRENDE AGUA, UN PRIMER SOLVENTE ORGÁNICO, UNA PRIMERA BASE, Y UN CATALIZADOR METAL DE TRANSICIÓN PARA OBTENER EL COMPUESTO 4; III) OXIDAR EL COMPUESTO 4 PARA OBTENER EL COMPUESTO 5; IV) AGREGAR UN GRUPO AMINA EN LA POSICIÓN 6 DE LA FRACCIÓN PIRIDILO DEL COMPUESTO 5 PARA OBTENER EL COMPUESTO 6; V) HACER REACCIONAR EL COMPUESTO 6 CON EL COMPUESTO 7, EN UN SEGUNDO SOLVENTE ORGÁNICO EN PRESENCIA DE UNA SEGUNDA BASE PARA PRODUCIR EL COMPUESTO 8; VI) DES–ESTERIFICAR EL COMPUESTO 8 EN UNA MEZCLA BIFÁSICA QUE COMPRENDE AGUA, UN TERCER SOLVENTE ORGÁNICO Y UN ÁCIDO PARA PRODUCIR EL COMPUESTO 9; Y VII) PREPARAR UNA PASTA CON EL COMPUESTO 9 EN AGUA O UNA MEZCLA 50% METANOL/AGUA, O DISOLVER EL COMPUESTO 9 PARA PRODUCIR LA FORMA I DEL COMPUESTO 1.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CL2018000300A CL2018000300A1 (es) | 2008-12-04 | 2018-02-01 | Procesos para producir acido benzoico de cicloalquilcarboxamido-piridina |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1218107P | 2007-12-07 | 2007-12-07 | |
US10957308P | 2008-10-30 | 2008-10-30 | |
PCT/US2008/085458 WO2009076142A2 (en) | 2007-12-07 | 2008-12-04 | Processes for producing cycloalkylcarboxiamido-pyridine benzoic acids |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2010000631A1 true CL2010000631A1 (es) | 2011-04-01 |
Family
ID=40329178
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2010000631A CL2010000631A1 (es) | 2007-12-07 | 2010-06-16 | Proceso para preparar la forma i del acido 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-il)ciclopropancarboxamido)-3-metilpiridin-2-il)benzoico (compuesto 1) a partir de 2-bromo-3-metilpiridina (compuesto 2) y ácido 3-(t-butoxicarbonil)fenilboronico (compuesto 3). |
Country Status (26)
Country | Link |
---|---|
US (4) | US8124781B2 (es) |
EP (4) | EP2231606B1 (es) |
JP (4) | JP5702149B2 (es) |
KR (3) | KR20150066608A (es) |
CN (2) | CN103864678B (es) |
AU (1) | AU2008335440B2 (es) |
BR (1) | BRPI0820902A2 (es) |
CA (3) | CA2989620C (es) |
CL (1) | CL2010000631A1 (es) |
CY (4) | CY1113985T1 (es) |
DK (4) | DK2639224T3 (es) |
EA (1) | EA201070700A1 (es) |
ES (4) | ES2406940T3 (es) |
HK (2) | HK1146820A1 (es) |
HR (4) | HRP20130418T1 (es) |
HU (3) | HUE032268T2 (es) |
IL (4) | IL206205A (es) |
LT (3) | LT2639222T (es) |
MX (4) | MX365732B (es) |
NZ (3) | NZ585794A (es) |
PL (4) | PL2639224T3 (es) |
PT (4) | PT2639224T (es) |
RS (4) | RS55360B1 (es) |
SI (4) | SI2231606T1 (es) |
WO (1) | WO2009076142A2 (es) |
ZA (1) | ZA201003624B (es) |
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