BR0317183A - Método de usar compostos de aminocianopiridina como inibidores de proteìna quinase-2 ativada por proteìna quinase ativada por mitógeno - Google Patents

Método de usar compostos de aminocianopiridina como inibidores de proteìna quinase-2 ativada por proteìna quinase ativada por mitógeno

Info

Publication number
BR0317183A
BR0317183A BR0317183-3A BR0317183A BR0317183A BR 0317183 A BR0317183 A BR 0317183A BR 0317183 A BR0317183 A BR 0317183A BR 0317183 A BR0317183 A BR 0317183A
Authority
BR
Brazil
Prior art keywords
protein kinase
activated protein
inhibitors
mitogen
aminocyanopyridine
Prior art date
Application number
BR0317183-3A
Other languages
English (en)
Inventor
Emily J Reinhard
Stephen A Kolodziej
David R Anderson
Nathan W Stehle
William F Vernier
Len F Lee
Shridhar G Hedge
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of BR0317183A publication Critical patent/BR0317183A/pt

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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Abstract

"MéTODO DE USAR COMPOSTOS DE AMINOCIANOPIRIDINA COMO INIBIDORES DE PROTEìNA QUINASE-2 ATIVADA POR PROTEìNA QUINASE ATIVADA POR MITóGENO". Um método é descrito para inibir proteína quinase-2 ativada por proteína quinase ativada por mitógeno em um indivíduo em necessidade de tal inibição onde o método envolve administrar ao indivíduo um composto inibidor de MK-2 de aminocianopiridina, ou um sal farmaceuticamente aceitável deste.
BR0317183-3A 2002-12-12 2003-12-09 Método de usar compostos de aminocianopiridina como inibidores de proteìna quinase-2 ativada por proteìna quinase ativada por mitógeno BR0317183A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43280702P 2002-12-12 2002-12-12
PCT/US2003/039166 WO2004054505A2 (en) 2002-12-12 2003-12-09 Method of using aminocyanopyridine compounds as mitogen activated protein kinase-activated protein kinase-2 inhibitors

Publications (1)

Publication Number Publication Date
BR0317183A true BR0317183A (pt) 2005-11-01

Family

ID=32595087

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0317183-3A BR0317183A (pt) 2002-12-12 2003-12-09 Método de usar compostos de aminocianopiridina como inibidores de proteìna quinase-2 ativada por proteìna quinase ativada por mitógeno

Country Status (7)

Country Link
EP (1) EP1569645A2 (pt)
JP (1) JP2006512338A (pt)
AU (1) AU2003296414A1 (pt)
BR (1) BR0317183A (pt)
CA (1) CA2508780A1 (pt)
MX (1) MXPA05006367A (pt)
WO (1) WO2004054505A2 (pt)

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