SG101291G - Podophyllotoxin derivatives - Google Patents

Podophyllotoxin derivatives

Info

Publication number
SG101291G
SG101291G SG1012/91A SG101291A SG101291G SG 101291 G SG101291 G SG 101291G SG 1012/91 A SG1012/91 A SG 1012/91A SG 101291 A SG101291 A SG 101291A SG 101291 G SG101291 G SG 101291G
Authority
SG
Singapore
Prior art keywords
podophyllotoxin derivatives
podophyllotoxin
derivatives
Prior art date
Application number
SG1012/91A
Other languages
English (en)
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of SG101291G publication Critical patent/SG101291G/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Cable Accessories (AREA)
SG1012/91A 1987-08-04 1991-11-29 Podophyllotoxin derivatives SG101291G (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8149387A 1987-08-04 1987-08-04
US07/199,731 US4904768A (en) 1987-08-04 1988-05-27 Epipodophyllotoxin glucoside 4'-phosphate derivatives

Publications (1)

Publication Number Publication Date
SG101291G true SG101291G (en) 1992-01-17

Family

ID=26765636

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1012/91A SG101291G (en) 1987-08-04 1991-11-29 Podophyllotoxin derivatives

Country Status (34)

Country Link
US (3) US4904768A (es)
JP (1) JPH0699465B2 (es)
KR (1) KR900006230B1 (es)
CN (1) CN1027169C (es)
AT (1) AT398974B (es)
BE (1) BE1002982A4 (es)
CA (1) CA1310637C (es)
CH (1) CH676716A5 (es)
CY (1) CY1625A (es)
CZ (1) CZ286893B6 (es)
DD (2) DD274423A5 (es)
DE (1) DE3826562A1 (es)
DK (2) DK169344B1 (es)
ES (1) ES2010775A6 (es)
FI (1) FI87790C (es)
FR (1) FR2622193B1 (es)
GB (1) GB2207674B (es)
GR (1) GR1000490B (es)
HK (1) HK6392A (es)
HU (3) HU202547B (es)
IE (1) IE61040B1 (es)
IL (1) IL87290A (es)
IT (1) IT1226825B (es)
LU (2) LU87290A1 (es)
MX (1) MX173843B (es)
MY (1) MY104321A (es)
NL (2) NL192683C (es)
NO (4) NO170284C (es)
NZ (1) NZ225615A (es)
PT (1) PT88186B (es)
SE (1) SE502214C2 (es)
SG (1) SG101291G (es)
SK (1) SK279325B6 (es)
YU (3) YU143688A (es)

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US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
US6610299B1 (en) 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5552154A (en) * 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
US4997931A (en) * 1990-06-11 1991-03-05 Bristol-Myers Squibb Company Epipodophyllotoxin glycosides
TW260671B (es) * 1991-04-29 1995-10-21 Bristol Myers Squibb Co
IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5648474A (en) * 1991-10-08 1997-07-15 Bristol-Myers Squibb Crystalline etoposide 4'-phosphate diethanolate
JPH07632B2 (ja) * 1991-12-23 1995-01-11 ブリストル−マイヤーズ スクイブ カンパニー エトポシド４’−ホスフェート二ナトリウム塩の安定な六水和物
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
FR2725990B1 (fr) * 1994-10-21 1997-01-10 Pf Medicament Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux
US5942386A (en) * 1995-06-07 1999-08-24 Thomas Jefferson University Anti-fungal agents and methods of identifying and using the same
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US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
WO1999032499A1 (en) * 1997-12-23 1999-07-01 Korea Research Institute Of Chemical Technology 4'-O-DEMETHYL-EPIPODOPHYLLOTOXIN-β-D-GLUCOSIDE ACETAL DERIVATIVES
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
EP1438319A1 (en) * 2001-10-26 2004-07-21 Centre National De La Recherche Scientifique (Cnrs) Derivatives of etoposide and analogs, and pharmaceutical compositions containing them
NZ537690A (en) 2002-07-15 2009-07-31 Univ Texas Antibodies binding to anionic phospholipids and aminophospholipids and their use in treating viral infections
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CN100334090C (zh) * 2005-02-02 2007-08-29 南京医科大学 吡啶类鬼臼毒素化合物及其制备方法和在制备杀虫剂中的应用
US20090016959A1 (en) * 2005-02-18 2009-01-15 Richard Beliveau Delivery of antibodies to the central nervous system
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CN100410266C (zh) * 2006-01-11 2008-08-13 重庆华邦制药股份有限公司 鬼臼毒素磷酸酯衍生物的合成方法
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US8263644B2 (en) * 2007-09-13 2012-09-11 Bristol-Myers Squibb Company Cytotoxic xanthone compounds
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JP2012505637A (ja) 2008-10-15 2012-03-08 アンジオケム，インコーポレーテッド Ｇｌｐ−１アゴニストのコンジュゲート及びその使用
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KR101928116B1 (ko) 2011-01-31 2018-12-11 노파르티스 아게 신규 헤테로시클릭 유도체
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
CA2853256C (en) 2011-10-28 2019-05-14 Novartis Ag Novel purine derivatives and their use in the treatment of disease
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SG11201406550QA (en) 2012-05-16 2014-11-27 Novartis Ag Dosage regimen for a pi-3 kinase inhibitor
JP2016508979A (ja) 2012-12-20 2016-03-24 デメレックス， インコーポレイテッド 置換ノルイボガイン
KR20160095035A (ko) 2013-12-06 2016-08-10 노파르티스 아게 알파-이소형 선택성 포스파티딜이노시톨 3-키나제 억제제를 위한 투여 요법
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FR1171314A (fr) * 1955-05-13 1959-01-23 Sandoz Ag Produits de condensation de glucosides avec des composés carbonyliques et leur préparation
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CH464957A (de) * 1965-12-14 1968-11-15 Sandoz Ag Verfahren zur Herstellung eines neuen Glucosids
CH484101A (de) * 1966-12-13 1970-01-15 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
CH514578A (de) * 1968-02-27 1971-10-31 Sandoz Ag Verfahren zur Herstellung von Glucosiden
CH543502A (de) * 1970-11-20 1973-10-31 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
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FR2397425A1 (fr) * 1977-07-11 1979-02-09 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
DE3374317D1 (en) * 1982-11-26 1987-12-10 Nippon Kayaku Kk Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
US4567253A (en) * 1984-02-03 1986-01-28 Tony Durst 2-Substituted derivatives of podophyllotoxin and etoposide
JPS60208910A (ja) * 1984-03-31 1985-10-21 Green Cross Corp:The 水難溶性薬物・リン脂質複合体の製造方法
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Also Published As

Publication number Publication date
HU905862D0 (en) 1991-03-28
FR2622193A1 (fr) 1989-04-28
IE61040B1 (en) 1994-09-07
CN1027169C (zh) 1994-12-28
GB2207674B (en) 1991-09-11
YU10490A (en) 1990-06-30
IT1226825B (it) 1991-02-19
NL970042I1 (nl) 1998-03-02
HUT47303A (en) 1989-02-28
SK541288A3 (en) 1998-10-07
KR890003790A (ko) 1989-04-18
HU211960A9 (en) 1996-01-29
FI87790C (fi) 1993-02-25
NL8801934A (nl) 1989-03-01
DK11992A (da) 1992-01-31
DD299067A5 (de) 1992-03-26
PT88186B (pt) 1995-07-03
FR2622193B1 (fr) 1993-12-17
NO883299L (no) 1989-02-24
NZ225615A (en) 1991-06-25
JPH0699465B2 (ja) 1994-12-07
ES2010775A6 (es) 1989-12-01
HU202547B (en) 1991-03-28
SE8802815D0 (sv) 1988-08-03
CN1061225A (zh) 1992-05-20
IE882378L (en) 1989-02-04
GB8818462D0 (en) 1988-09-07
IL87290A0 (en) 1989-01-31
CH676716A5 (es) 1991-02-28
CZ286893B6 (cs) 2000-07-12
PT88186A (pt) 1989-06-30
HK6392A (en) 1992-01-17
NO172440B (no) 1993-04-13
DK169344B1 (da) 1994-10-10
USRE35524E (en) 1997-06-03
AU2030688A (en) 1989-06-08
LU90138I2 (fr) 1997-11-26
YU10390A (en) 1990-06-30
US5041424A (en) 1991-08-20
AT398974B (de) 1995-02-27
NO920665L (no) 1989-02-24
NO920277D0 (no) 1992-01-22
SE502214C2 (sv) 1995-09-18
DK434088D0 (da) 1988-08-03
NO920665D0 (no) 1992-02-20
SK279325B6 (sk) 1998-10-07
GR1000490B (el) 1992-07-30
NO920277L (no) 1989-02-24
AU610619B2 (en) 1991-05-23
DE3826562C2 (es) 1993-04-08
LU87290A1 (fr) 1990-02-07
NL970042I2 (es) 2005-06-01
SE8802815L (sv) 1989-02-05
KR900006230B1 (ko) 1990-08-27
YU143688A (en) 1990-04-30
FI883596A0 (fi) 1988-08-01
NO172440C (no) 1993-07-21
MY104321A (en) 1994-03-31
US4904768A (en) 1990-02-27
DE3826562A1 (de) 1989-02-16
HU208147B (en) 1993-08-30
FI87790B (fi) 1992-11-13
JPH01100188A (ja) 1989-04-18
CA1310637C (en) 1992-11-24
GR880100512A (en) 1989-05-25
BE1002982A4 (fr) 1991-10-15
MX9202851A (es) 1992-06-30
NO170284B (no) 1992-06-22
NO1998002I1 (no) 1998-01-14
MX173843B (es) 1994-03-30
NO883299D0 (no) 1988-07-26
NL192683B (es) 1997-08-01
DK434088A (da) 1989-02-05
DK11992D0 (da) 1992-01-31
IL87290A (en) 1993-01-31
GB2207674A (en) 1989-02-08
IT8821535A0 (it) 1988-07-28
ATA195588A (de) 1994-07-15
NL192683C (nl) 1997-12-02
FI883596A (fi) 1989-02-05
DD274423A5 (de) 1989-12-20
CZ541288A3 (cs) 1999-12-15
CY1625A (en) 1992-07-10
NO170284C (no) 1992-09-30

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