SE502214C2 - Epipodofyllotoxin-glukosid-4'-fosfat-derivat samt förfarande för deras framställning - Google Patents

Epipodofyllotoxin-glukosid-4'-fosfat-derivat samt förfarande för deras framställning

Info

Publication number
SE502214C2
SE502214C2 SE8802815A SE8802815A SE502214C2 SE 502214 C2 SE502214 C2 SE 502214C2 SE 8802815 A SE8802815 A SE 8802815A SE 8802815 A SE8802815 A SE 8802815A SE 502214 C2 SE502214 C2 SE 502214C2
Authority
SE
Sweden
Prior art keywords
formula
compound
alkyl
substituted
compounds according
Prior art date
Application number
SE8802815A
Other languages
English (en)
Swedish (sv)
Other versions
SE8802815D0 (sv
SE8802815L (sv
Inventor
Mark G Saulnier
Peter D Senter
John F Kadow
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of SE8802815D0 publication Critical patent/SE8802815D0/xx
Publication of SE8802815L publication Critical patent/SE8802815L/xx
Publication of SE502214C2 publication Critical patent/SE502214C2/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Cable Accessories (AREA)
SE8802815A 1987-08-04 1988-08-03 Epipodofyllotoxin-glukosid-4'-fosfat-derivat samt förfarande för deras framställning SE502214C2 (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8149387A 1987-08-04 1987-08-04
US07/199,731 US4904768A (en) 1987-08-04 1988-05-27 Epipodophyllotoxin glucoside 4'-phosphate derivatives

Publications (3)

Publication Number Publication Date
SE8802815D0 SE8802815D0 (sv) 1988-08-03
SE8802815L SE8802815L (sv) 1989-02-05
SE502214C2 true SE502214C2 (sv) 1995-09-18

Family

ID=26765636

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8802815A SE502214C2 (sv) 1987-08-04 1988-08-03 Epipodofyllotoxin-glukosid-4'-fosfat-derivat samt förfarande för deras framställning

Country Status (34)

Country Link
US (3) US4904768A (es)
JP (1) JPH0699465B2 (es)
KR (1) KR900006230B1 (es)
CN (1) CN1027169C (es)
AT (1) AT398974B (es)
BE (1) BE1002982A4 (es)
CA (1) CA1310637C (es)
CH (1) CH676716A5 (es)
CY (1) CY1625A (es)
CZ (1) CZ286893B6 (es)
DD (2) DD274423A5 (es)
DE (1) DE3826562A1 (es)
DK (2) DK169344B1 (es)
ES (1) ES2010775A6 (es)
FI (1) FI87790C (es)
FR (1) FR2622193B1 (es)
GB (1) GB2207674B (es)
GR (1) GR1000490B (es)
HK (1) HK6392A (es)
HU (3) HU202547B (es)
IE (1) IE61040B1 (es)
IL (1) IL87290A (es)
IT (1) IT1226825B (es)
LU (2) LU87290A1 (es)
MX (1) MX173843B (es)
MY (1) MY104321A (es)
NL (2) NL192683C (es)
NO (4) NO170284C (es)
NZ (1) NZ225615A (es)
PT (1) PT88186B (es)
SE (1) SE502214C2 (es)
SG (1) SG101291G (es)
SK (1) SK279325B6 (es)
YU (3) YU143688A (es)

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US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
US6610299B1 (en) 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5552154A (en) * 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
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US5648474A (en) * 1991-10-08 1997-07-15 Bristol-Myers Squibb Crystalline etoposide 4'-phosphate diethanolate
JPH07632B2 (ja) * 1991-12-23 1995-01-11 ブリストル−マイヤーズ スクイブ カンパニー エトポシド４’−ホスフェート二ナトリウム塩の安定な六水和物
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
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EP2289549A3 (en) 1999-10-01 2011-06-15 Immunogen, Inc. Immunoconjugates for treating cancer
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
WO2003035661A1 (en) * 2001-10-26 2003-05-01 Centre National De La Recherche Scientifique Derivatives of etoposide and analogs, and pharmaceutical compositions containing them
ES2358730T3 (es) 2002-07-15 2011-05-13 Board Of Regents, The University Of Texas System Anticuerpos seleccionados y péptidos de duramicina que se enlazan a fosfolípidos aniónicos y aminofosfolípidos y sus usos en el tratamiento de infecciones virales y del cáncer.
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US20090016959A1 (en) * 2005-02-18 2009-01-15 Richard Beliveau Delivery of antibodies to the central nervous system
ES2383901T5 (es) * 2005-02-18 2015-02-25 Angiochem Inc. Polipéptidos de aprotinina para transportar un compuesto a través de la barrera sangre-cerebro
EP2233156B1 (en) 2005-07-15 2013-05-01 Angiochem Inc. Use of aprotinin polypeptides as carriers in pharmaceutical conjugates
CN100410266C (zh) * 2006-01-11 2008-08-13 重庆华邦制药股份有限公司 鬼臼毒素磷酸酯衍生物的合成方法
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Also Published As

Publication number Publication date
NZ225615A (en) 1991-06-25
IT1226825B (it) 1991-02-19
LU87290A1 (fr) 1990-02-07
IL87290A (en) 1993-01-31
CZ286893B6 (cs) 2000-07-12
MY104321A (en) 1994-03-31
NL192683C (nl) 1997-12-02
HK6392A (en) 1992-01-17
NL8801934A (nl) 1989-03-01
ATA195588A (de) 1994-07-15
NL970042I2 (es) 2005-06-01
CH676716A5 (es) 1991-02-28
FI87790C (fi) 1993-02-25
FI883596A0 (fi) 1988-08-01
IE882378L (en) 1989-02-04
FR2622193A1 (fr) 1989-04-28
DK169344B1 (da) 1994-10-10
JPH01100188A (ja) 1989-04-18
DK11992A (da) 1992-01-31
US5041424A (en) 1991-08-20
BE1002982A4 (fr) 1991-10-15
YU10390A (en) 1990-06-30
FI87790B (fi) 1992-11-13
AT398974B (de) 1995-02-27
DD274423A5 (de) 1989-12-20
NO170284C (no) 1992-09-30
NL192683B (es) 1997-08-01
PT88186B (pt) 1995-07-03
IL87290A0 (en) 1989-01-31
GR880100512A (en) 1989-05-25
FR2622193B1 (fr) 1993-12-17
HU208147B (en) 1993-08-30
DK434088A (da) 1989-02-05
CZ541288A3 (cs) 1999-12-15
NO883299L (no) 1989-02-24
CA1310637C (en) 1992-11-24
GB8818462D0 (en) 1988-09-07
GR1000490B (el) 1992-07-30
US4904768A (en) 1990-02-27
GB2207674B (en) 1991-09-11
SE8802815D0 (sv) 1988-08-03
PT88186A (pt) 1989-06-30
SK541288A3 (en) 1998-10-07
NO883299D0 (no) 1988-07-26
HU211960A9 (en) 1996-01-29
DK434088D0 (da) 1988-08-03
YU10490A (en) 1990-06-30
NO920277D0 (no) 1992-01-22
DD299067A5 (de) 1992-03-26
YU143688A (en) 1990-04-30
KR890003790A (ko) 1989-04-18
CN1061225A (zh) 1992-05-20
ES2010775A6 (es) 1989-12-01
HU905862D0 (en) 1991-03-28
CY1625A (en) 1992-07-10
FI883596A (fi) 1989-02-05
NO1998002I1 (no) 1998-01-14
KR900006230B1 (ko) 1990-08-27
DE3826562C2 (es) 1993-04-08
NO920665D0 (no) 1992-02-20
SE8802815L (sv) 1989-02-05
DE3826562A1 (de) 1989-02-16
NO170284B (no) 1992-06-22
HU202547B (en) 1991-03-28
AU2030688A (en) 1989-06-08
MX173843B (es) 1994-03-30
NO172440B (no) 1993-04-13
NL970042I1 (nl) 1998-03-02
CN1027169C (zh) 1994-12-28
USRE35524E (en) 1997-06-03
IE61040B1 (en) 1994-09-07
SG101291G (en) 1992-01-17
MX9202851A (es) 1992-06-30
HUT47303A (en) 1989-02-28
DK11992D0 (da) 1992-01-31
NO172440C (no) 1993-07-21
NO920665L (no) 1989-02-24
GB2207674A (en) 1989-02-08
IT8821535A0 (it) 1988-07-28
LU90138I2 (fr) 1997-11-26
JPH0699465B2 (ja) 1994-12-07
SK279325B6 (sk) 1998-10-07
NO920277L (no) 1989-02-24
AU610619B2 (en) 1991-05-23

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