RU2751362C2 - Способы получения экспрессирующих химерный антигенный рецептор клеток - Google Patents

Способы получения экспрессирующих химерный антигенный рецептор клеток Download PDF

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RU2751362C2
RU2751362C2 RU2017127051A RU2017127051A RU2751362C2 RU 2751362 C2 RU2751362 C2 RU 2751362C2 RU 2017127051 A RU2017127051 A RU 2017127051A RU 2017127051 A RU2017127051 A RU 2017127051A RU 2751362 C2 RU2751362 C2 RU 2751362C2
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cells
car
population
cell
immune effector
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RU2017127051A
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RU2017127051A3 (enExample
RU2017127051A (ru
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Фелипе БЕДОЙА
Саба ГХАССЕМИ
Карл Х. Джун
Брюс Л. Левин
Ян Дж. МИЛЕНХОРСТ
Майкл С. Майлон
Дэниэл Дж. Мл. ПАУЭЛЛ
Зоуи ЧЖЭН
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Новартис Аг
Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
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RU2017127051A 2014-12-29 2015-12-28 Способы получения экспрессирующих химерный антигенный рецептор клеток RU2751362C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462097375P 2014-12-29 2014-12-29
US62/097,375 2014-12-29
US201562133137P 2015-03-13 2015-03-13
US62/133,137 2015-03-13
PCT/US2015/067635 WO2016109410A2 (en) 2014-12-29 2015-12-28 Methods of making chimeric antigen receptor-expressing cells

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RU2021118125A Division RU2863430C2 (ru) 2014-12-29 2015-12-28 Способы получения экспрессирующих химерный антигенный рецептор клеток

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RU2017127051A RU2017127051A (ru) 2019-02-01
RU2017127051A3 RU2017127051A3 (enExample) 2019-09-27
RU2751362C2 true RU2751362C2 (ru) 2021-07-13

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US (3) US10273300B2 (enExample)
EP (2) EP3240803B1 (enExample)
JP (3) JP2018500944A (enExample)
KR (2) KR20250075716A (enExample)
CN (2) CN107567461A (enExample)
AU (3) AU2015374296B2 (enExample)
CA (2) CA2972597A1 (enExample)
IL (2) IL253149B2 (enExample)
RU (1) RU2751362C2 (enExample)
SG (1) SG11201705293WA (enExample)
TW (1) TW201631152A (enExample)
WO (1) WO2016109410A2 (enExample)

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WO2014130635A1 (en) 2013-02-20 2014-08-28 Novartis Ag Effective targeting of primary human leukemia using anti-cd123 chimeric antigen receptor engineered t cells
ES2769574T3 (es) 2013-03-15 2020-06-26 Michael C Milone Reconocimiento de células citotóxicas con receptores quiméricos para inmunoterapia adoptiva
UY35468A (es) 2013-03-16 2014-10-31 Novartis Ag Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19
ES2918501T3 (es) 2013-12-19 2022-07-18 Novartis Ag Receptores de antígenos quiméricos de mesotelina humana y usos de los mismos
WO2015090229A1 (en) 2013-12-20 2015-06-25 Novartis Ag Regulatable chimeric antigen receptor
EP3097117B1 (en) 2014-01-21 2023-10-04 Novartis Ag Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules
SG10202109752XA (en) 2014-04-07 2021-10-28 Novartis Ag Treatment of cancer using anti-cd19 chimeric antigen receptor
IL292038B2 (en) 2014-04-23 2024-12-01 Juno Therapeutics Inc Methods for enriching or producing immune cell populations for adoptive therapy
WO2016014553A1 (en) 2014-07-21 2016-01-28 Novartis Ag Sortase synthesized chimeric antigen receptors
JP6831777B2 (ja) 2014-07-21 2021-02-17 ノバルティス アーゲー Ｃｄ３３キメラ抗原受容体を使用する癌の処置
AU2015292744C1 (en) 2014-07-21 2021-01-21 Novartis Ag Treatment of cancer using humanized anti-BCMA chimeric antigen receptor
BR112017000939A2 (pt) 2014-07-21 2017-11-14 Novartis Ag tratamento de câncer usando um receptor antigênico quimérico de cll-1
EP3712171A1 (en) 2014-08-19 2020-09-23 Novartis AG Treatment of cancer using a cd123 chimeric antigen receptor
US10577417B2 (en) 2014-09-17 2020-03-03 Novartis Ag Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
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WO2016073955A2 (en) 2014-11-06 2016-05-12 President And Fellows Of Harvard College Cells lacking b2m surface expression and methods for allogeneic administration of such cells
RU2751362C2 (ru) 2014-12-29 2021-07-13 Новартис Аг Способы получения экспрессирующих химерный антигенный рецептор клеток
US11459390B2 (en) 2015-01-16 2022-10-04 Novartis Ag Phosphoglycerate kinase 1 (PGK) promoters and methods of use for expressing chimeric antigen receptor
WO2016126608A1 (en) 2015-02-02 2016-08-11 Novartis Ag Car-expressing cells against multiple tumor antigens and uses thereof
US11241505B2 (en) 2015-02-13 2022-02-08 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
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