RU2559541C2 - Универсальная система подготовки образцов и применение в интегрированной системе анализа - Google Patents
Универсальная система подготовки образцов и применение в интегрированной системе анализа Download PDFInfo
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2659155C1 (ru) * | 2017-06-27 | 2018-06-28 | Ольга Владимировна Кондратенко | Способ сбора и первичного посева жидкости назального лаважа от пациентов с муковисцидозом для микробиологического исследования |
RU2749333C2 (ru) * | 2016-09-29 | 2021-06-08 | Байонир Корпорейшн | Устройство для обработки биологических образцов |
RU219829U1 (ru) * | 2022-12-22 | 2023-08-09 | Федеральное государственное автономное образовательное учреждение высшего образования "Российский национальный исследовательский медицинский университет имени Н.И. Пирогова" Министерства здравоохранения Российской Федерации (ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России) | Анализатор одноразового микрофлюидного картриджа |
Families Citing this family (246)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6432290B1 (en) | 1999-11-26 | 2002-08-13 | The Governors Of The University Of Alberta | Apparatus and method for trapping bead based reagents within microfluidic analysis systems |
CA2290731A1 (en) * | 1999-11-26 | 2001-05-26 | D. Jed Harrison | Apparatus and method for trapping bead based reagents within microfluidic analysis system |
JP2006512092A (ja) * | 2002-12-30 | 2006-04-13 | ザ・リージェンツ・オブ・ジ・ユニバーシティ・オブ・カリフォルニア | 病原体の検出および分析のための方法および装置 |
US7799553B2 (en) * | 2004-06-01 | 2010-09-21 | The Regents Of The University Of California | Microfabricated integrated DNA analysis system |
EP2261650A3 (de) | 2004-09-15 | 2011-07-06 | IntegenX Inc. | Mikrofluidische Vorrichtungen |
GB0421529D0 (en) | 2004-09-28 | 2004-10-27 | Landegren Gene Technology Ab | Microfluidic structure |
JP5063616B2 (ja) | 2006-02-03 | 2012-10-31 | インテジェニックス インコーポレイテッド | マイクロ流体デバイス |
US7766033B2 (en) | 2006-03-22 | 2010-08-03 | The Regents Of The University Of California | Multiplexed latching valves for microfluidic devices and processors |
WO2007124105A2 (en) | 2006-04-21 | 2007-11-01 | Nanobiosym, Inc. | Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents |
WO2008052138A2 (en) | 2006-10-25 | 2008-05-02 | The Regents Of The University Of California | Inline-injection microdevice and microfabricated integrated dna analysis system using same |
WO2008115626A2 (en) | 2007-02-05 | 2008-09-25 | Microchip Biotechnologies, Inc. | Microfluidic and nanofluidic devices, systems, and applications |
US9557217B2 (en) * | 2007-02-13 | 2017-01-31 | Bti Holdings, Inc. | Universal multidetection system for microplates |
US8841135B2 (en) * | 2007-06-20 | 2014-09-23 | University Of Washington | Biochip for high-throughput screening of circulating tumor cells |
WO2009015296A1 (en) * | 2007-07-24 | 2009-01-29 | The Regents Of The University Of California | Microfabricated dropley generator |
WO2013006312A2 (en) * | 2011-07-06 | 2013-01-10 | Advanced Liquid Logic Inc | Reagent storage on a droplet actuator |
US8623789B2 (en) * | 2009-09-21 | 2014-01-07 | Akonni Biosystems, Inc. | Integrated cartridge |
EP2234916A4 (de) * | 2008-01-22 | 2016-08-10 | Integenx Inc | Universelles probenpräparationssystem und seine verwendung in einem integrierten analysesystem |
CN102341691A (zh) | 2008-12-31 | 2012-02-01 | 尹特根埃克斯有限公司 | 具有微流体芯片的仪器 |
EP2394152B1 (de) | 2009-02-03 | 2019-05-01 | ANDE Corporation | Nukleinsäureaufreinigung |
BRPI0924255A2 (pt) * | 2009-02-17 | 2016-01-26 | Medimate Holding B V | equipamento para a medição de uma concentração de uma espécie carregada em uma amostra |
EP2438154A1 (de) | 2009-06-02 | 2012-04-11 | Integenx Inc. | Fluidische vorrichtung mit membranventilen |
AU2010257118B2 (en) * | 2009-06-04 | 2014-08-28 | Lockheed Martin Corporation | Multiple-sample microfluidic chip for DNA analysis |
KR20120031218A (ko) | 2009-06-05 | 2012-03-30 | 인터젠엑스 인크. | 만능 샘플 제조 시스템 및 집적 분석 시스템에서의 사용 |
US8584703B2 (en) | 2009-12-01 | 2013-11-19 | Integenx Inc. | Device with diaphragm valve |
US9188243B2 (en) * | 2010-01-29 | 2015-11-17 | The Trustees Of Columbia University In The City Of New York | Microfluidic flow devices, methods and systems |
CN102906573B (zh) * | 2010-02-23 | 2015-02-18 | 瑞昂尼克公司 | 独立式生物检测装置、方法和应用 |
US8277544B2 (en) * | 2010-03-26 | 2012-10-02 | Agilent Technologies, Inc. | Thermal modulation device for two dimensional gas chromatography |
US8512538B2 (en) | 2010-05-28 | 2013-08-20 | Integenx Inc. | Capillary electrophoresis device |
US20110312676A1 (en) * | 2010-06-17 | 2011-12-22 | Geneasys Pty Ltd | Loc device with integral driver for excitation of electrochemiluminescent luminophores |
WO2012024658A2 (en) | 2010-08-20 | 2012-02-23 | IntegenX, Inc. | Integrated analysis system |
WO2012024657A1 (en) | 2010-08-20 | 2012-02-23 | IntegenX, Inc. | Microfluidic devices with mechanically-sealed diaphragm valves |
GB201016014D0 (en) * | 2010-09-24 | 2010-11-10 | Epistem Ltd | Thermal cycler |
WO2020041260A1 (en) | 2018-08-20 | 2020-02-27 | Vanderbilt University | Multichannel pumps and applications of same |
US11465144B2 (en) | 2010-10-07 | 2022-10-11 | Vanderbilt University | Cartridge systems, capacitive pumps and multi-throw valves and pump-valve systems and applications of same |
CA2814720C (en) | 2010-10-15 | 2016-12-13 | Lockheed Martin Corporation | Micro fluidic optic design |
CA3177188A1 (en) * | 2011-01-06 | 2012-07-12 | Meso Scale Technologies, Llc. | Assay cartridges for pcr analysis and methods of use thereof |
CN103608110B (zh) * | 2011-03-09 | 2017-06-06 | 彼克斯赛尔医疗科技有限公司 | 用于制备用于分析的包含细胞的样品流体的一次性盒子 |
JP5279926B2 (ja) * | 2011-03-23 | 2013-09-04 | アークレイ株式会社 | 分析装置、及び分析方法 |
US9121047B2 (en) | 2011-04-07 | 2015-09-01 | Life Technologies Corporation | System and methods for making and processing emulsions |
US9017993B2 (en) * | 2011-04-07 | 2015-04-28 | Life Technologies Corporation | System and methods for making and processing emulsions |
CA2838198A1 (en) * | 2011-06-09 | 2012-12-13 | Ge Healthcare Limited | Distillation device and method |
WO2013019714A1 (en) | 2011-07-29 | 2013-02-07 | The Trustees Of Columbia University In The City Of New York | Mems affinity sensor for continuous monitoring of analytes |
ES2797448T3 (es) | 2011-08-01 | 2020-12-02 | Bio Rad Laboratories | Sistema de captura de células |
US10466160B2 (en) * | 2011-08-01 | 2019-11-05 | Celsee Diagnostics, Inc. | System and method for retrieving and analyzing particles |
US9404864B2 (en) | 2013-03-13 | 2016-08-02 | Denovo Sciences, Inc. | System for imaging captured cells |
WO2013044217A1 (en) * | 2011-09-23 | 2013-03-28 | The Trustees Of Columbia University In The City Of New York | Isolation and enrichment of nucleic acids on microchip |
US20150136604A1 (en) * | 2011-10-21 | 2015-05-21 | Integenx Inc. | Sample preparation, processing and analysis systems |
US8894946B2 (en) | 2011-10-21 | 2014-11-25 | Integenx Inc. | Sample preparation, processing and analysis systems |
US10865440B2 (en) | 2011-10-21 | 2020-12-15 | IntegenX, Inc. | Sample preparation, processing and analysis systems |
WO2013130910A1 (en) * | 2012-02-29 | 2013-09-06 | Integenx Inc. | Sample preparation, processing and analysis systems |
US9138714B2 (en) | 2011-10-31 | 2015-09-22 | General Electric Company | Microfluidic chip and a related method thereof |
KR101355994B1 (ko) * | 2011-11-22 | 2014-01-29 | 한국과학기술원 | 병원체 검출용 마이크로디바이스 |
SG11201402558QA (en) * | 2011-12-03 | 2014-06-27 | Emd Millipore Corp | Micro-incubation systems for microfluidic cell culture and methods |
JP6296992B2 (ja) * | 2011-12-16 | 2018-03-20 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドSiemens Healthcare Diagnostics Inc. | 試薬カード位置合わせ装置及び方法 |
US9322054B2 (en) | 2012-02-22 | 2016-04-26 | Lockheed Martin Corporation | Microfluidic cartridge |
DK2825309T3 (en) | 2012-03-16 | 2018-07-30 | Stat Diagnostica & Innovation Sl | Sample cartridge with integrated transfer module |
EP2829882B8 (de) * | 2012-03-21 | 2020-04-01 | NEC Corporation | Chip zur analyse einer zielsubstanz |
KR101211862B1 (ko) | 2012-04-30 | 2012-12-12 | 한국기계연구원 | 자기장을 이용하는 자가 세포 추출장치 및 이를 이용하는 방법 |
WO2013166857A1 (en) * | 2012-05-07 | 2013-11-14 | Capitalbio Corporation | Microfluidic devices for multi-index biochemical detection |
ITMI20120902A1 (it) * | 2012-05-24 | 2013-11-25 | Inpeco Ip Ltd | Apparato di automazione distribuita per diagnostica di laboratorio. |
ES2445842B1 (es) * | 2012-09-04 | 2015-03-16 | Universidad De Alcalá | Instrumento de electroforesis capilar portátil semiautomático |
US9580679B2 (en) * | 2012-09-21 | 2017-02-28 | California Institute Of Technology | Methods and devices for sample lysis |
WO2014092652A1 (en) | 2012-12-14 | 2014-06-19 | Agency For Science, Technology And Research | Devices for extracting at least one analyte |
KR101544089B1 (ko) * | 2012-12-27 | 2015-08-13 | 나노바이오시스 주식회사 | 식중독 검출용 프라이머 세트를 포함하는 마이크로 pcr 칩, 이를 포함하는 실시간 pcr 장치, 및 이를 이용한 식중독 검출 방법 |
US9606102B2 (en) | 2013-01-26 | 2017-03-28 | Denovo Sciences, Inc. | System and method for capturing and analyzing cells |
JP6086755B2 (ja) * | 2013-02-26 | 2017-03-01 | 国立大学法人九州大学 | マイクロチップを用いた光分析方法および光分析装置、ならびに光分析用処理装置 |
US10545161B2 (en) | 2013-03-11 | 2020-01-28 | Cue Health Inc. | Systems and methods for detection and quantification of analytes |
IL297030B2 (en) | 2013-03-11 | 2024-03-01 | Cue Health Inc | A method for activating fluid flow within a microfluidic cartridge |
US9623409B2 (en) | 2013-03-11 | 2017-04-18 | Cue Inc. | Cartridges, kits, and methods for enhanced mixing for detection and quantification of analytes |
US9458488B2 (en) * | 2013-03-15 | 2016-10-04 | Nanomix, Inc. | Point of care sensor systems |
US10656149B2 (en) | 2013-03-15 | 2020-05-19 | The Trustees Of Princeton University | Analyte detection enhancement by targeted immobilization, surface amplification, and pixelated reading and analysis |
KR20230069244A (ko) * | 2013-03-15 | 2023-05-18 | 나노바이오심 인크. | 핵산들 및 단백질들의 모바일 디바이스 분석을 위한 시스템들 및 방법들 |
US10933417B2 (en) | 2013-03-15 | 2021-03-02 | Nanobiosym, Inc. | Systems and methods for mobile device analysis of nucleic acids and proteins |
WO2014144133A1 (en) * | 2013-03-15 | 2014-09-18 | The Trustees Of The Princeton University | Analyte detection enhancement by targeted immobilization, surface amplification, and pixelated reading and analysis |
US10391490B2 (en) | 2013-05-31 | 2019-08-27 | Celsee Diagnostics, Inc. | System and method for isolating and analyzing cells |
US9856535B2 (en) | 2013-05-31 | 2018-01-02 | Denovo Sciences, Inc. | System for isolating cells |
WO2015031351A1 (en) * | 2013-08-26 | 2015-03-05 | Diagenetix, Inc. | Hardware and mobile software for operation of portable instruments for nucleic acid amplification |
WO2015073999A1 (en) | 2013-11-18 | 2015-05-21 | Integenx Inc. | Cartridges and instruments for sample analysis |
US10220387B2 (en) | 2013-12-05 | 2019-03-05 | The General Hospital Corporation | Modular instrumentation for analyzing biological fluids |
WO2015089621A1 (en) * | 2013-12-18 | 2015-06-25 | Handyem Inc. | Chip assembly, flow cell and flow cytometer for characterizing particles |
JP6714517B2 (ja) * | 2014-03-07 | 2020-06-24 | ライフ テクノロジーズ コーポレーション | キャピラリー電気泳動システムのためのキャピラリーアレイカートリッジ |
US10195610B2 (en) | 2014-03-10 | 2019-02-05 | Click Diagnostics, Inc. | Cartridge-based thermocycler |
CN204727866U (zh) * | 2014-03-31 | 2015-10-28 | 博奥生物集团有限公司 | 一种集核酸扩增和微阵列检测于一体的微流控装置 |
US10253357B2 (en) | 2014-04-24 | 2019-04-09 | Diassess Inc. | Colorimetric detection of nucleic acid amplification |
WO2015168374A1 (en) | 2014-05-01 | 2015-11-05 | Diomics Corporation | Devices and kits for collection, storage and analysis of samples and methods of production and use thereof |
USD745423S1 (en) | 2014-05-12 | 2015-12-15 | Cue Inc. | Automated analyzer test cartridge and sample collection device for analyte detection |
US10208332B2 (en) | 2014-05-21 | 2019-02-19 | Integenx Inc. | Fluidic cartridge with valve mechanism |
CN105316226A (zh) * | 2014-05-31 | 2016-02-10 | 捷普科技(上海)有限公司 | 升降机构及具备该升降机构的生物芯片检测装置 |
KR102615349B1 (ko) * | 2014-06-17 | 2023-12-20 | 라이프 테크놀로지스 코포레이션 | 핀치 흐름 조정기 |
WO2015195975A1 (en) * | 2014-06-18 | 2015-12-23 | The Regents Of The University Of California | Raman imaging systems and methods |
WO2016022696A1 (en) | 2014-08-05 | 2016-02-11 | The Trustees Of Columbia University In The City Of New York | Method of isolating aptamers for minimal residual disease detection |
WO2016022559A1 (en) * | 2014-08-08 | 2016-02-11 | Nanostring Technologies, Inc. | Methods for deconvolution of mixed cell populations using gene expression data |
WO2016025021A1 (en) | 2014-08-15 | 2016-02-18 | Diomics Corporation | Films for biologic analyte collection and analysis and methods of production and use thereof |
US11066636B2 (en) | 2014-08-29 | 2021-07-20 | Nec Corporation | Microchip, microchip controlling apparatus and microchip controlling system technical field |
JP2016067318A (ja) * | 2014-09-30 | 2016-05-09 | 株式会社東芝 | 核酸検査システム |
EP3209410A4 (de) * | 2014-10-22 | 2018-05-02 | IntegenX Inc. | Systeme und verfahren zur automatisierten vorbereitung, verarbeitung und analyse von proben |
US10210410B2 (en) | 2014-10-22 | 2019-02-19 | Integenx Inc. | Systems and methods for biometric data collections |
CA2965657A1 (en) * | 2014-10-28 | 2016-05-06 | Envirologix Inc. | Sample preparation vessels, microfluidic circuits, and systems and methods for sample preparation, extraction, and analysis |
US11478789B2 (en) | 2014-11-26 | 2022-10-25 | Medica Corporation | Automated microscopic cell analysis |
US10625259B1 (en) | 2014-11-26 | 2020-04-21 | Medica Corporation | Automated microscopic cell analysis |
US20170328924A1 (en) | 2014-11-26 | 2017-11-16 | Ronald Jones | Automated microscopic cell analysis |
CA2972587A1 (en) | 2014-12-31 | 2016-07-07 | Click Diagnostics, Inc. | Devices and methods for molecular diagnostic testing |
EP3046134A1 (de) * | 2015-01-15 | 2016-07-20 | Bruker Daltonik GmbH | Gasanalysator mit Brennstoffzelle |
WO2016117725A1 (en) * | 2015-01-23 | 2016-07-28 | Infopia Co., Ltd. | Molecular diagnostic cartridge |
WO2016122643A1 (en) * | 2015-01-30 | 2016-08-04 | Hewlett-Packard Development Company, L.P. | Diagnostic chip |
EP3257066A4 (de) * | 2015-02-10 | 2018-10-03 | Indiana University Research & Technology Corporation | Vorrichtung und verfahren zur analyse von bioflüssigkeiten durch ionenerzeugung mit einem befeuchteten porösen material |
EP3265863B1 (de) | 2015-02-13 | 2021-12-08 | The Regents of The University of California | Abtastverfahren zur gleichmässigen senkrechteinfall-bildgebung von sphärischen oberflächen mit einem einzelnen strahl |
DE102015205435B4 (de) * | 2015-03-25 | 2023-02-16 | Robert Bosch Gmbh | Sequenziervorrichtung und Verfahren zum Betreiben einer Sequenziervorrichtung |
WO2016150991A1 (en) * | 2015-03-25 | 2016-09-29 | Stat Peel Ag | Device for measuring the exposure to small particles, in particular nano tubes |
WO2016170185A1 (en) | 2015-04-24 | 2016-10-27 | Ifp Privates Institut Fuer Produktqualitaet Gmbh | Apparatus and method for converting electromagnetic radiation into thermal energy |
US11260386B2 (en) | 2015-06-05 | 2022-03-01 | The Emerther Company | Component of a device, a device, and a method for purifying and testing biomolecules from biological samples |
WO2016198748A1 (en) * | 2015-06-10 | 2016-12-15 | Thermo Fisher Scientific Oy | Extraction column |
US10233491B2 (en) | 2015-06-19 | 2019-03-19 | IntegenX, Inc. | Valved cartridge and system |
WO2016209735A1 (en) | 2015-06-22 | 2016-12-29 | Fluxergy, Llc | Camera imaging system for a fluid sample assay and method of using same |
US10214772B2 (en) | 2015-06-22 | 2019-02-26 | Fluxergy, Llc | Test card for assay and method of manufacturing same |
US11371091B2 (en) | 2015-06-22 | 2022-06-28 | Fluxergy, Inc. | Device for analyzing a fluid sample and use of test card with same |
US11940422B2 (en) | 2015-07-12 | 2024-03-26 | Pharmafluidics Nv | Microfluidic device |
BE1023273B1 (nl) * | 2015-07-12 | 2017-01-19 | PharmaFluidics N.V. | Microfluïdische inrichting |
CN117310193A (zh) | 2015-07-17 | 2023-12-29 | 克忧健康公司 | 用于增强检测和分析物定量的系统及方法 |
BR112018003614A2 (pt) * | 2015-08-26 | 2018-09-25 | EMULATE, Inc. | conjunto distribuidor de perfusão |
US20180259481A1 (en) * | 2015-09-20 | 2018-09-13 | Dh Technologies Development Pte. Ltd. | Small Sample Injection Vial |
US10905113B2 (en) | 2015-11-12 | 2021-02-02 | Regents Of The University Of Minnesota | Compositions and method for storing liquid biospecimens |
KR102447394B1 (ko) | 2015-12-03 | 2022-09-27 | 프리시젼바이오 주식회사 | 유체분석 카트리지 및 이를 포함하는 유체분석장치 |
WO2017100283A1 (en) * | 2015-12-09 | 2017-06-15 | Life Technologies Corporation | Detection and quantification of nucleic acid molecules associated with a surface |
US9513220B1 (en) | 2015-12-29 | 2016-12-06 | International Business Machines Corporation | On-chip molecule fluorescence detection |
CA3011620A1 (en) | 2016-02-01 | 2017-08-10 | Li-Cor, Inc. | Capillary electrophoresis inkjet dispensing |
CA3014055A1 (en) * | 2016-02-12 | 2017-08-17 | Laboratory Corporation Of America Holdings | Direct specimen collection device and cassette |
WO2017160840A1 (en) | 2016-03-14 | 2017-09-21 | Diassess Inc. | Selectively vented biological assay devices and associated methods |
WO2017167575A1 (en) | 2016-03-29 | 2017-10-05 | Ge Healthcare Bio-Sciences Corp. | Self-contained slide processing unit for biological specimens |
CN106483178A (zh) * | 2016-03-31 | 2017-03-08 | 广州万孚生物技术股份有限公司 | 血气分析仪及其血气生化测试卡 |
EP3443357A4 (de) * | 2016-04-13 | 2019-02-20 | Shenzhen Genorivision Technology Co., Ltd. | Multifunktionelle mikrofluidikvorrichtung für das screening von biologischen proben |
WO2017181200A1 (en) | 2016-04-15 | 2017-10-19 | The Regents Of The University Of California | Assessment of wound status and tissue viability via analysis of spatially resolved thz reflectometry maps |
EP3442398A4 (de) | 2016-04-15 | 2019-12-11 | The Regents of The University of California | Thz-erfassung des wassergehalts von hornhautgewebe |
US10987674B2 (en) | 2016-04-22 | 2021-04-27 | Visby Medical, Inc. | Printed circuit board heater for an amplification module |
WO2017197040A1 (en) | 2016-05-11 | 2017-11-16 | Click Diagnostics, Inc. | Devices and methods for nucleic acid extraction |
CN105891278A (zh) * | 2016-05-12 | 2016-08-24 | 绍兴文理学院 | 用液压滤波、电磁离心和相邻电容的磨损微粒监测装置 |
CA3023234A1 (en) * | 2016-05-17 | 2017-11-23 | Integrated Nano-Technologies, Inc. | Filtration column assembly for a diagnostic assay system |
WO2017205267A1 (en) | 2016-05-22 | 2017-11-30 | Cornell University | Multifunctional microfluidic device for capturing target cells and analyzing genomic dna isolated from the target cells while under flow conditions |
CA3023300C (en) * | 2016-05-23 | 2020-03-10 | Becton, Dickinson And Company | Liquid dispenser with manifold mount for modular independently-actuated pipette channels |
USD800331S1 (en) | 2016-06-29 | 2017-10-17 | Click Diagnostics, Inc. | Molecular diagnostic device |
WO2018005710A1 (en) | 2016-06-29 | 2018-01-04 | Click Diagnostics, Inc. | Devices and methods for the detection of molecules using a flow cell |
USD800914S1 (en) | 2016-06-30 | 2017-10-24 | Click Diagnostics, Inc. | Status indicator for molecular diagnostic device |
USD800913S1 (en) | 2016-06-30 | 2017-10-24 | Click Diagnostics, Inc. | Detection window for molecular diagnostic device |
CA3031226A1 (en) | 2016-08-08 | 2018-02-15 | Li-Cor, Inc. | Multi-sheath flow and on-chip terminating electrode for microfluidic direct-blotting |
US11241689B2 (en) * | 2016-08-08 | 2022-02-08 | Li-Cor, Inc. | Microchip electrophoresis inkjet dispensing |
SG11201901032PA (en) * | 2016-08-15 | 2019-03-28 | Greyscan Pty Ltd | Elution and detection |
US10525461B2 (en) * | 2016-08-30 | 2020-01-07 | Bigtec Private Limited | Cartridge for purification of biological samples |
EP3510396B1 (de) | 2016-09-08 | 2021-12-08 | Hemex Health, Inc. | Diagnosesystem |
US10349589B2 (en) | 2016-09-08 | 2019-07-16 | Hemex Health, Inc. | Diagnostics systems and methods |
US20180088049A1 (en) * | 2016-09-26 | 2018-03-29 | Azure Biosystems, Inc. | Methods and devices for photometric analysis |
US20190367904A1 (en) * | 2016-11-07 | 2019-12-05 | Zymo Research Corporation | Automated method for release of nucleic acids from microbial samples |
US11237161B2 (en) | 2017-01-25 | 2022-02-01 | Cue Health Inc. | Systems and methods for enhanced detection and quantification of analytes |
US11480567B2 (en) | 2017-02-15 | 2022-10-25 | New Jersey Institute Of Technology | Enhanced sensitivity and specificity for point-of-care (POC) micro biochip |
EP3586118B1 (de) * | 2017-02-24 | 2023-12-27 | Life Technologies Corporation | Kapillarelektrophoresesystem |
GB201703233D0 (en) * | 2017-02-28 | 2017-04-12 | Ge Healthcare Bio Sciences Ab | A modular bio-processing unit and a bio-processing system employing plural units |
US10632464B2 (en) * | 2017-02-28 | 2020-04-28 | Alere San Diego, Inc. | Microfluidic devices and related methods |
EP3607087A4 (de) * | 2017-04-04 | 2020-12-30 | Omniome, Inc. | Fluidische vorrichtung und verfahren für chemische und biologische reaktionen |
US11080848B2 (en) | 2017-04-06 | 2021-08-03 | Lucira Health, Inc. | Image-based disease diagnostics using a mobile device |
CN114471758B (zh) * | 2017-05-11 | 2023-10-17 | 芯易诊有限公司 | 样品分析系统 |
WO2018217721A1 (en) * | 2017-05-22 | 2018-11-29 | Integenx Inc. | Serial electrophoresis |
KR102205804B1 (ko) * | 2017-05-24 | 2021-01-22 | 바이오파이어 디펜스, 엘엘씨 | 사용 시점에서 어레이의 배기를 위한 시스템 및 방법 |
CA3065928A1 (en) * | 2017-06-06 | 2018-12-13 | Northwestern University | Trans-interfacial magnetic separation |
CN110869114B (zh) * | 2017-07-04 | 2023-01-31 | 布鲁塞尔自由大学 | 液滴和/或气泡发生器 |
US10330573B2 (en) | 2017-07-10 | 2019-06-25 | Cem Corporation | Rapid sample preparation for analytical analysis using dispersive energized extraction |
US10241014B2 (en) | 2017-07-10 | 2019-03-26 | Cem Corporation | Instrument for analytical sample preparation |
US10295447B2 (en) | 2017-07-10 | 2019-05-21 | Cem Corporation | Rapid energized dispersive solid phase extraction (SPE) for analytical analysis |
US10391492B2 (en) | 2017-08-29 | 2019-08-27 | Celsee Diagnostics, Inc. | System and method for isolating and analyzing cells |
CN111295442A (zh) * | 2017-08-31 | 2020-06-16 | 拜奥法尔防护有限责任公司 | 测定设备及其使用方法 |
US10549275B2 (en) | 2017-09-14 | 2020-02-04 | Lucira Health, Inc. | Multiplexed biological assay device with electronic readout |
GB201715399D0 (en) * | 2017-09-22 | 2017-11-08 | Ge Healthcare Bio Sciences Ab | Valve unit for a chromatography apparatus |
US11543402B2 (en) * | 2017-10-19 | 2023-01-03 | Analog Devices, Inc. | Impedance measurement in diagnostic testing |
US11020740B2 (en) | 2017-10-24 | 2021-06-01 | New Jersey Institute Of Technology | Microfluidic biochip with enhanced sensitivity |
US20200299677A1 (en) | 2017-10-27 | 2020-09-24 | Juno Diagnostics, Inc. | Devices, systems and methods for ultra-low volume liquid biopsy |
EP3707276A4 (de) | 2017-11-09 | 2022-02-23 | Visby Medical, Inc. | Tragbare molekulardiagnostikvorrichtung und verfahren zur detektion von zielviren |
US11047845B1 (en) | 2017-11-15 | 2021-06-29 | Medica Corporation | Control material and methods for cell analyzers |
WO2019104337A1 (en) | 2017-11-27 | 2019-05-31 | The Trustees Of Columbia University In The City Of New York | Rna printing and sequencing devices, methods, and systems |
US11510608B2 (en) * | 2017-12-14 | 2022-11-29 | Essenlix Corporation | Devices, systems, and methods for monitoring hair |
WO2019133718A1 (en) * | 2017-12-29 | 2019-07-04 | The Regents Of The University Of Colorado, A Body Corporate | Hi-fidelity bioaerosol condensation capture directly into genomic preservatives |
WO2019140532A1 (en) * | 2018-01-19 | 2019-07-25 | Spartan Bioscience Inc. | Fluid handling apparatus |
CN111902213B (zh) * | 2018-01-29 | 2022-12-06 | 简·探针公司 | 分析系统和方法 |
CN110157590A (zh) * | 2018-02-13 | 2019-08-23 | 光鼎生物科技(江苏)有限公司 | 热循环仪 |
JP2021515899A (ja) * | 2018-03-02 | 2021-06-24 | テレフレックス メディカル インコーポレイテッド | 感染検出システムおよび方法 |
EP3910320A1 (de) * | 2018-03-29 | 2021-11-17 | The Automation Partnership (Cambridge) Ltd. | Computerimplementiertes verfahren und system zur spektroskopischen analyse von biologischem material |
CN108717476B (zh) * | 2018-04-12 | 2020-07-24 | 北京交通大学 | 基于cots部件构成的安全苛求系统进行故障注入测试的方法 |
WO2019209374A1 (en) | 2018-04-24 | 2019-10-31 | Hewlett-Packard Development Company, L.P. | Sequenced droplet ejection to deliver fluids |
WO2020018074A1 (en) | 2018-07-17 | 2020-01-23 | Hewlett-Packard Development Company, L.P. | Droplet ejectors to provide fluids to droplet ejectors |
US11925932B2 (en) | 2018-04-24 | 2024-03-12 | Hewlett-Packard Development Company, L.P. | Microfluidic devices |
DE102018111834A1 (de) * | 2018-05-16 | 2019-11-21 | Mildendo Gesellschaft für mikrofluidische Systeme mbH | Mikrofluidische Vorrichtung und Verfahren zur Nutzung derselben zur Trennung, Aufreinigung und Konzentration von Komponenten von fluidischen Medien, |
US11547993B2 (en) | 2018-07-17 | 2023-01-10 | Hewlett-Packard Development Company, L.P. | Droplet ejectors with target media |
EP3628071B1 (de) * | 2018-07-27 | 2022-07-06 | Zepto Life Technology, LLC | System und verfahren zur probenvorbereitung bei der gmr-basierten detektion von biomarkern |
US11768188B2 (en) | 2018-10-24 | 2023-09-26 | Climate Llc | Cartridge-based sensor system for monitoring properties of field soils and wastewater |
CN113286656B (zh) | 2018-12-04 | 2023-07-14 | 尹特根埃克斯有限公司 | 用于制备测定的包含dna样品的方法和系统 |
JP2022517906A (ja) * | 2018-12-10 | 2022-03-11 | コンビナティ インコーポレイテッド | 試料のデジタル化のためのマイクロ流体アレイ |
US11185860B2 (en) * | 2018-12-12 | 2021-11-30 | Wisconsin Alumni Research Foundation | Platform for multi-variable screening |
CN109649694B (zh) * | 2018-12-20 | 2022-01-11 | 深圳航天东方红海特卫星有限公司 | 一种电致变色热控机构 |
USD907232S1 (en) | 2018-12-21 | 2021-01-05 | Lucira Health, Inc. | Medical testing device |
MX2021010609A (es) * | 2019-03-05 | 2021-12-10 | Lucira Health Inc | Llenado de líquidos sin burbujas de cámaras de fluidos. |
CN109933031B (zh) * | 2019-03-26 | 2021-08-31 | 沈阳铝镁设计研究院有限公司 | 一种根据化验数据自动校正软测量仪表的系统及方法 |
US11783195B2 (en) | 2019-03-27 | 2023-10-10 | Cognizant Technology Solutions U.S. Corporation | Process and system including an optimization engine with evolutionary surrogate-assisted prescriptions |
US11738345B2 (en) * | 2019-04-08 | 2023-08-29 | Miroculus Inc. | Multi-cartridge digital microfluidics apparatuses and methods of use |
US10633693B1 (en) | 2019-04-16 | 2020-04-28 | Celsee Diagnostics, Inc. | System and method for leakage control in a particle capture system |
US11968975B2 (en) | 2019-04-30 | 2024-04-30 | Regents Of The University Of Minnesota | Compositions and methods for storing liquid biospecimens |
US20220072549A1 (en) * | 2019-04-30 | 2022-03-10 | Hewlett-Packard Development Company, L.P. | Microfluidic concentrating particlizers |
SG11202112151UA (en) | 2019-05-07 | 2021-12-30 | Bio Rad Laboratories | System and method for automated single cell processing |
US11273439B2 (en) | 2019-05-07 | 2022-03-15 | Bio-Rad Laboratories, Inc. | System and method for target material retrieval from microwells |
EP3887832A4 (de) * | 2019-06-04 | 2022-10-26 | Hewlett-Packard Development Company, L.P. | Integrierte mikrofluidische auswerferchips |
CA3143241A1 (en) | 2019-06-14 | 2020-12-17 | Bio-Rad Laboratories, Inc. | System and method for automated single cell processing and analyses |
WO2020264182A1 (en) | 2019-06-25 | 2020-12-30 | Hemex Health, Inc. | Diagnostics systems and methods |
JP2022538359A (ja) * | 2019-06-27 | 2022-09-01 | セル マイクロシステムズ インク | 単一細胞イメージングをrnaトランスクリプトミクスと関連付けるためのシステムと方法 |
WO2021011309A1 (en) * | 2019-07-12 | 2021-01-21 | Cumbo Thomas A | Biological transport systems and methods |
BR112022000722A2 (pt) * | 2019-07-16 | 2022-03-08 | Meliolabs Inc | Métodos e dispositivos para curva de melting digital baseada em célula única |
KR102262630B1 (ko) * | 2019-07-17 | 2021-06-10 | (주)리젠케어 | 변형가능한 세포배양 스캐폴드와 이를 이용한 치료제의 제조방법 |
CN117169534A (zh) | 2019-08-05 | 2023-12-05 | 禧尔公司 | 用于样品制备、数据生成和蛋白质冠分析的系统和方法 |
JP2022553609A (ja) * | 2019-08-30 | 2022-12-26 | タリン ユニヴァーシティ オブ テクノロジー | 禁止物質を決定するための装置および方法 |
US20220381775A1 (en) * | 2019-10-28 | 2022-12-01 | Genotix Biotechnologies Inc. | Analyte detection and quantification by discrete enumeration of particle complexes |
US20220404353A1 (en) * | 2019-11-27 | 2022-12-22 | Juno Diagnostics, Inc. | Systems and devices for sample preparation and analyte detection |
EP3845790B1 (de) * | 2019-12-30 | 2024-04-17 | Imec VZW | Mikrofluidische vorrichtung zur steuerung von pneumatischen mikroventilen |
WO2021138544A1 (en) | 2020-01-03 | 2021-07-08 | Visby Medical, Inc. | Devices and methods for antibiotic susceptibility testing |
EP4127211A4 (de) * | 2020-03-26 | 2024-01-03 | Siemens Healthcare Diagnostics Inc | Automatisiertes molekulares testsystem mit wahlfreiem zugriff |
US20210354133A1 (en) * | 2020-04-22 | 2021-11-18 | Quantum-Si Incorporated | Enrichment and depletion of target molecules for sequencing |
CN111554009B (zh) * | 2020-04-23 | 2022-01-11 | 赣州深奥科技有限公司 | 一种指纹头结构 |
USD953561S1 (en) | 2020-05-05 | 2022-05-31 | Lucira Health, Inc. | Diagnostic device with LED display |
USD962470S1 (en) | 2020-06-03 | 2022-08-30 | Lucira Health, Inc. | Assay device with LCD display |
CN113804909B (zh) * | 2020-06-12 | 2023-12-12 | 中国科学院苏州纳米技术与纳米仿生研究所 | 真空互联样品转移组件 |
US11775841B2 (en) | 2020-06-15 | 2023-10-03 | Cognizant Technology Solutions U.S. Corporation | Process and system including explainable prescriptions through surrogate-assisted evolution |
WO2021262501A1 (en) * | 2020-06-25 | 2021-12-30 | Siemens Healthcare Diagnostics Inc. | Biological sample analyzer with automatic thermal cooling adjustment for altitude |
CN113967486A (zh) * | 2020-07-22 | 2022-01-25 | 京东方科技集团股份有限公司 | 离心式微流控芯片 |
US20230047306A1 (en) * | 2020-07-22 | 2023-02-16 | Telosair Corp. | Electrostatic Precipitation-Based Sampler for Bioaerosol Monitoring |
WO2022024368A1 (ja) * | 2020-07-31 | 2022-02-03 | 株式会社日立ハイテク | キャピラリ電気泳動装置 |
KR102442502B1 (ko) * | 2020-08-12 | 2022-09-13 | 중앙대학교 산학협력단 | 시료 농축용 카트리지 |
US11964278B2 (en) * | 2020-09-08 | 2024-04-23 | Dartmouth Ocean Technologies Inc. | Microfluidic chip, systems, and methods for capturing of environmental DNA |
AU2021364540A1 (en) * | 2020-10-19 | 2023-06-22 | Formulatrix International Holding Ltd. | Apparatuses with fluidic channel geometries for sample to answer pcr analysis and methods of using same |
CN112080806B (zh) * | 2020-10-23 | 2024-02-20 | 江苏吉诺思美精准医学科技有限公司 | 一种毛细管96孔板的血浆游离dna建库方法 |
US20220155187A1 (en) * | 2020-11-16 | 2022-05-19 | Koninklijke Fabriek Inventum B.V. | Methods of obtaining a biological sample representative of a passenger cabin on an aircraft using an air cyclonic collector |
CN114768894B (zh) * | 2021-01-22 | 2023-08-11 | 中国科学院上海微系统与信息技术研究所 | 一种检测芯片及检测方法 |
WO2022160998A1 (zh) * | 2021-01-29 | 2022-08-04 | 广东润鹏生物技术有限公司 | 分子诊断平台 |
WO2022261194A2 (en) * | 2021-06-08 | 2022-12-15 | Cognizant Technology Solutions U.S. Corporation | System and method for generating improved prescriptors |
CN117651612A (zh) * | 2021-07-08 | 2024-03-05 | ams国际有限公司 | 微流体装置和微流体测量布置 |
CN113960147A (zh) * | 2021-10-19 | 2022-01-21 | 南京晓庄学院 | 一种毛细管电泳电化学发光检测装置 |
CN114453044B (zh) * | 2022-02-24 | 2023-08-22 | 中国科学院苏州生物医学工程技术研究所 | 微流控芯片装夹装置 |
WO2023200805A1 (en) * | 2022-04-13 | 2023-10-19 | Phylagen, Inc. | Automated microbial fluid sampling and analysis systems and processes |
CN114833799B (zh) * | 2022-04-26 | 2024-01-02 | 浙江大学 | 一种用于养殖场动物唾液样本无人化采集的机器人和方法 |
WO2023220055A1 (en) * | 2022-05-09 | 2023-11-16 | Synthego Corporation | Systems and methods for handling and transferring fluids aseptically via microfluidic components |
WO2023244987A2 (en) * | 2022-06-12 | 2023-12-21 | Pfizer Inc. | Systems and methods for performing biological assays using a thermally sealed valve |
CN115015567B (zh) * | 2022-08-05 | 2022-11-11 | 南京纳摩尔仪器有限公司 | 一种陶瓷3d隧式分析模块 |
CN115646563A (zh) * | 2022-10-14 | 2023-01-31 | 广州迪澳医疗科技有限公司 | 一种微流控芯片及其制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070034025A1 (en) * | 2005-08-09 | 2007-02-15 | Cfd Research Corporation | Electrostatic sampler and method |
US20080014576A1 (en) * | 2006-02-03 | 2008-01-17 | Microchip Biotechnologies, Inc. | Microfluidic devices |
US20080164155A1 (en) * | 2003-01-31 | 2008-07-10 | Grant Pease | Microfluidic device with thin-film electronic devices |
Family Cites Families (403)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3075740A (en) | 1960-06-02 | 1963-01-29 | Dow Chemical Co | Diaphragm valve |
US3352643A (en) | 1964-09-02 | 1967-11-14 | Hitachi Ltd | Liquid chromatography and chromatographs |
US3433257A (en) | 1966-02-01 | 1969-03-18 | Ibm | Diaphragm type fluid logic latch |
US3568692A (en) | 1967-11-27 | 1971-03-09 | Bowles Eng Corp | Optical machining process |
US3662517A (en) | 1970-04-08 | 1972-05-16 | Sherwood Medical Ind Inc | Syringe filling apparatus |
US4011357A (en) | 1974-03-07 | 1977-03-08 | Mobil Oil Corporation | Laminate of biaxially oriented polystyrene film and polystyrene foam |
US4113665A (en) | 1977-02-03 | 1978-09-12 | Ameron, Inc. | Coatings prepared from trialkoxysilanes |
US4963498A (en) | 1985-08-05 | 1990-10-16 | Biotrack | Capillary flow device |
GB8523166D0 (en) * | 1985-09-19 | 1985-10-23 | Yarsley Technical Centre Ltd | Scratch resistant coatings |
US5085757A (en) * | 1987-11-25 | 1992-02-04 | Northeastern University | Integrated temperature control/alignment system for high performance capillary electrophoretic apparatus |
US5523231A (en) | 1990-02-13 | 1996-06-04 | Amersham International Plc | Method to isolate macromolecules using magnetically attractable beads which do not specifically bind the macromolecules |
US5935401A (en) | 1996-09-18 | 1999-08-10 | Aclara Biosciences | Surface modified electrophoretic chambers |
US5770029A (en) | 1996-07-30 | 1998-06-23 | Soane Biosciences | Integrated electrophoretic microdevices |
US5750015A (en) | 1990-02-28 | 1998-05-12 | Soane Biosciences | Method and device for moving molecules by the application of a plurality of electrical fields |
US6176962B1 (en) | 1990-02-28 | 2001-01-23 | Aclara Biosciences, Inc. | Methods for fabricating enclosed microchannel structures |
US5387505A (en) * | 1990-05-04 | 1995-02-07 | Eastman Kodak Company | Preparation and isolation of single-stranded biotinylated nucleic acids by heat avidin-biotin cleavage |
SE470347B (sv) | 1990-05-10 | 1994-01-31 | Pharmacia Lkb Biotech | Mikrostruktur för vätskeflödessystem och förfarande för tillverkning av ett sådant system |
EP0459241B1 (de) | 1990-05-29 | 1994-10-26 | Waters Investments Limited | Verfahren und Vorrichtung zum Durchführen der Kapillarelektroforese |
US5364759B2 (en) | 1991-01-31 | 1999-07-20 | Baylor College Medicine | Dna typing with short tandem repeat polymorphisms and identification of polymorphic short tandem repeats |
JPH07209251A (ja) | 1994-01-14 | 1995-08-11 | Hitachi Ltd | 電気泳動装置 |
US5726026A (en) | 1992-05-01 | 1998-03-10 | Trustees Of The University Of Pennsylvania | Mesoscale sample preparation device and systems for determination and processing of analytes |
DE69319427T2 (de) | 1992-05-01 | 1998-12-10 | Univ Pennsylvania | Analyse bei messung des durchflusswiderstandes |
US5587128A (en) | 1992-05-01 | 1996-12-24 | The Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification devices |
US5304487A (en) * | 1992-05-01 | 1994-04-19 | Trustees Of The University Of Pennsylvania | Fluid handling in mesoscale analytical devices |
US5637469A (en) * | 1992-05-01 | 1997-06-10 | Trustees Of The University Of Pennsylvania | Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems |
US5275645A (en) * | 1992-11-24 | 1994-01-04 | Ameron, Inc. | Polysiloxane coating |
US5482836A (en) * | 1993-01-14 | 1996-01-09 | The Regents Of The University Of California | DNA purification by triplex-affinity capture and affinity capture electrophoresis |
EP0620432B1 (de) | 1993-04-15 | 2004-08-25 | Zeptosens AG | Verfahren zur Steuerung der Probeneinführung bei Mikrosäulentrennungstechniken und Probenentnahmevorrichtungen |
JP3563140B2 (ja) | 1995-01-19 | 2004-09-08 | 株式会社日立製作所 | キャピラリーアレイ電気泳動装置 |
US5482845A (en) | 1993-09-24 | 1996-01-09 | The Trustees Of Columbia University In The City Of New York | Method for construction of normalized cDNA libraries |
US5776748A (en) * | 1993-10-04 | 1998-07-07 | President And Fellows Of Harvard College | Method of formation of microstamped patterns on plates for adhesion of cells and other biological materials, devices and uses therefor |
US5453163A (en) | 1993-10-29 | 1995-09-26 | Yan; Chao | Electrokinetic packing of capillary columns |
US6358385B1 (en) * | 1993-12-17 | 2002-03-19 | The Perkin-Elmer Corporation | Polymers for separation of biomolecules by capillary electrophoresis |
US20070269799A9 (en) | 1994-06-22 | 2007-11-22 | Zhang David Y | Nucleic acid amplification methods |
US5639428A (en) * | 1994-07-19 | 1997-06-17 | Becton Dickinson And Company | Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay |
US6001229A (en) | 1994-08-01 | 1999-12-14 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis |
US5705628A (en) * | 1994-09-20 | 1998-01-06 | Whitehead Institute For Biomedical Research | DNA purification and isolation using magnetic particles |
WO1998053300A2 (en) | 1997-05-23 | 1998-11-26 | Lynx Therapeutics, Inc. | System and apparaus for sequential processing of analytes |
US5571410A (en) | 1994-10-19 | 1996-11-05 | Hewlett Packard Company | Fully integrated miniaturized planar liquid sample handling and analysis device |
US5775371A (en) | 1995-03-08 | 1998-07-07 | Abbott Laboratories | Valve control |
US5741462A (en) | 1995-04-25 | 1998-04-21 | Irori | Remotely programmable matrices with memories |
US5675155A (en) | 1995-04-26 | 1997-10-07 | Beckman Instruments, Inc. | Multicapillary fluorescent detection system |
US5589136A (en) | 1995-06-20 | 1996-12-31 | Regents Of The University Of California | Silicon-based sleeve devices for chemical reactions |
US6168948B1 (en) | 1995-06-29 | 2001-01-02 | Affymetrix, Inc. | Miniaturized genetic analysis systems and methods |
US5856174A (en) | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
US5872010A (en) * | 1995-07-21 | 1999-02-16 | Northeastern University | Microscale fluid handling system |
US20020068357A1 (en) | 1995-09-28 | 2002-06-06 | Mathies Richard A. | Miniaturized integrated nucleic acid processing and analysis device and method |
US5705813A (en) | 1995-11-01 | 1998-01-06 | Hewlett-Packard Company | Integrated planar liquid handling system for maldi-TOF MS |
EP0779512B1 (de) | 1995-12-14 | 2001-10-31 | Hewlett-Packard Company, A Delaware Corporation | Säule für kapillarchromatographische Trennverfahren |
US5863502A (en) | 1996-01-24 | 1999-01-26 | Sarnoff Corporation | Parallel reaction cassette and associated devices |
US5948684A (en) | 1997-03-31 | 1999-09-07 | University Of Washington | Simultaneous analyte determination and reference balancing in reference T-sensor devices |
US5885470A (en) * | 1997-04-14 | 1999-03-23 | Caliper Technologies Corporation | Controlled fluid transport in microfabricated polymeric substrates |
US5942443A (en) | 1996-06-28 | 1999-08-24 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices |
US5994064A (en) | 1996-04-24 | 1999-11-30 | Identigene, Inc. | Simple and complex tandem repeats with DNA typing method |
US6387707B1 (en) * | 1996-04-25 | 2002-05-14 | Bioarray Solutions | Array Cytometry |
AU3570797A (en) | 1996-06-14 | 1998-01-07 | University Of Washington | Absorption-enhanced differential extraction device |
BR9710054A (pt) * | 1996-06-28 | 2000-01-11 | Caliper Techn Corp | Aparelhos para separar compostos de teste para um efeito sobre um sistema bioquìmico e para detectar ummefeito de um composto de teste sobre um sistema bioquìmico, processos de determinação de se uma amostra contém um composto capaz de afetar um sistema bioquìmico, de separação de uma pluralidade de compostos de teste para um efeito sobre um sistema bioquìmico e usos de um sistema microfluido e de um substrato de ensaio. |
US6074827A (en) | 1996-07-30 | 2000-06-13 | Aclara Biosciences, Inc. | Microfluidic method for nucleic acid purification and processing |
US6136212A (en) | 1996-08-12 | 2000-10-24 | The Regents Of The University Of Michigan | Polymer-based micromachining for microfluidic devices |
US6110343A (en) | 1996-10-04 | 2000-08-29 | Lockheed Martin Energy Research Corporation | Material transport method and apparatus |
WO1998022625A1 (en) | 1996-11-20 | 1998-05-28 | The Regents Of The University Of Michigan | Microfabricated isothermal nucleic acid amplification devices and methods |
JPH10206384A (ja) | 1997-01-16 | 1998-08-07 | Kagaku Gijutsu Shinko Jigyodan | マルチキャピラリー電気泳動装置 |
US6306588B1 (en) * | 1997-02-07 | 2001-10-23 | Invitrogen Corporation | Polymerases for analyzing or typing polymorphic nucleic acid fragments and uses thereof |
US6117634A (en) | 1997-03-05 | 2000-09-12 | The Reagents Of The University Of Michigan | Nucleic acid sequencing and mapping |
US6235471B1 (en) | 1997-04-04 | 2001-05-22 | Caliper Technologies Corp. | Closed-loop biochemical analyzers |
US6391622B1 (en) | 1997-04-04 | 2002-05-21 | Caliper Technologies Corp. | Closed-loop biochemical analyzers |
WO1998045684A1 (en) | 1997-04-04 | 1998-10-15 | Biosite Diagnostics, Inc. | Methods for concentrating ligands using magnetic particles |
US6872527B2 (en) * | 1997-04-16 | 2005-03-29 | Xtrana, Inc. | Nucleic acid archiving |
US5951262A (en) | 1997-04-18 | 1999-09-14 | Centriflow Llc | Mechanism for providing motive force and for pumping applications |
EP0981408B1 (de) | 1997-05-16 | 2004-04-21 | Alberta Research Council | Mikrofluidisches system und verfahren zu dessen betrieb |
US6632619B1 (en) | 1997-05-16 | 2003-10-14 | The Governors Of The University Of Alberta | Microfluidic system and methods of use |
GB9713597D0 (en) | 1997-06-28 | 1997-09-03 | Sec Dep Of The Home Department | Improvements in and relating to forensic identification |
US6073482A (en) | 1997-07-21 | 2000-06-13 | Ysi Incorporated | Fluid flow module |
JP3481828B2 (ja) | 1997-08-26 | 2003-12-22 | 株式会社日立製作所 | 電気泳動分析装置,電気泳動分析方法及びそれに用いる試料容器 |
US20040017981A1 (en) * | 1997-09-11 | 2004-01-29 | Jovanovich Stevan Bogdan | Capillary valve, connector, and router |
US6190616B1 (en) | 1997-09-11 | 2001-02-20 | Molecular Dynamics, Inc. | Capillary valve, connector, and router |
WO1999014368A2 (en) * | 1997-09-15 | 1999-03-25 | Whitehead Institute For Biomedical Research | Methods and apparatus for processing a sample of biomolecular analyte using a microfabricated device |
US6007775A (en) | 1997-09-26 | 1999-12-28 | University Of Washington | Multiple analyte diffusion based chemical sensor |
US5842787A (en) | 1997-10-09 | 1998-12-01 | Caliper Technologies Corporation | Microfluidic systems incorporating varied channel dimensions |
AU1517999A (en) | 1997-10-15 | 1999-05-03 | Aclara Biosciences, Inc. | Laminate microstructure device and method for making same |
US5860594A (en) | 1997-12-19 | 1999-01-19 | Carrier Corporation | Method and apparatus for changing operational modes of a transport refrigeration system |
ES2309022T3 (es) | 1997-12-24 | 2008-12-16 | Cepheid | Dispositivo y procedimiento para lisis. |
US6167910B1 (en) | 1998-01-20 | 2001-01-02 | Caliper Technologies Corp. | Multi-layer microfluidic devices |
US6200814B1 (en) | 1998-01-20 | 2001-03-13 | Biacore Ab | Method and device for laminar flow on a sensing surface |
US6685809B1 (en) * | 1999-02-04 | 2004-02-03 | Ut-Battelle, Llc | Methods for forming small-volume electrical contacts and material manipulations with fluidic microchannels |
US6251343B1 (en) * | 1998-02-24 | 2001-06-26 | Caliper Technologies Corp. | Microfluidic devices and systems incorporating cover layers |
WO1999046591A2 (en) | 1998-03-10 | 1999-09-16 | Strategic Diagnostics, Inc. | Integrated assay device and methods of production and use |
US6979424B2 (en) | 1998-03-17 | 2005-12-27 | Cepheid | Integrated sample analysis device |
US6534262B1 (en) * | 1998-05-14 | 2003-03-18 | Whitehead Institute For Biomedical Research | Solid phase technique for selectively isolating nucleic acids |
US6627446B1 (en) | 1998-07-02 | 2003-09-30 | Amersham Biosciences (Sv) Corp | Robotic microchannel bioanalytical instrument |
US6787111B2 (en) | 1998-07-02 | 2004-09-07 | Amersham Biosciences (Sv) Corp. | Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis |
US6787308B2 (en) * | 1998-07-30 | 2004-09-07 | Solexa Ltd. | Arrayed biomolecules and their use in sequencing |
US6387234B1 (en) * | 1998-08-31 | 2002-05-14 | Iowa State University Research Foundation, Inc. | Integrated multiplexed capillary electrophoresis system |
US6103199A (en) | 1998-09-15 | 2000-08-15 | Aclara Biosciences, Inc. | Capillary electroflow apparatus and method |
US6572830B1 (en) | 1998-10-09 | 2003-06-03 | Motorola, Inc. | Integrated multilayered microfludic devices and methods for making the same |
EP1006355A3 (de) | 1998-11-30 | 2000-11-08 | The Institute of Physical and Chemical Research | Kapillarelektrophoresegerät |
US6887693B2 (en) * | 1998-12-24 | 2005-05-03 | Cepheid | Device and method for lysing cells, spores, or microorganisms |
GB9900298D0 (en) | 1999-01-07 | 1999-02-24 | Medical Res Council | Optical sorting method |
CA2359901A1 (en) | 1999-02-16 | 2000-08-24 | Pe Corporation (Ny) | Bead dispensing system |
US6153389A (en) | 1999-02-22 | 2000-11-28 | Haarer; Brian K. | DNA additives as a mechanism for unambiguously marking biological samples |
ATE508200T1 (de) * | 1999-02-23 | 2011-05-15 | Caliper Life Sciences Inc | Sequenzierung durch inkorporation |
EP1411340A3 (de) | 1999-02-26 | 2004-05-19 | EXACT Sciences Corporation | Biochemische Reinigungsvorrichtungen mit immobilisierten Fang-Sonden und ihre Verwendungszwecke |
WO2000050870A1 (en) | 1999-02-26 | 2000-08-31 | Mosaic Technologies | Biochemical purification devices with immobilized capture probes and their uses |
US6319476B1 (en) | 1999-03-02 | 2001-11-20 | Perseptive Biosystems, Inc. | Microfluidic connector |
US7150994B2 (en) | 1999-03-03 | 2006-12-19 | Symyx Technologies, Inc. | Parallel flow process optimization reactor |
US6048100A (en) | 1999-03-10 | 2000-04-11 | Industrial Label Corp. | Resealable closure for a bag |
US6994986B2 (en) * | 1999-03-17 | 2006-02-07 | The Board Of Trustees Of The Leland Stanford University | In vitro synthesis of polypeptides by optimizing amino acid metabolism |
WO2000060362A1 (en) | 1999-04-08 | 2000-10-12 | Chung Chang Young | Apparatus for fast preparation and analysis of nucleic acids |
JP3746658B2 (ja) | 1999-04-12 | 2006-02-15 | 株式会社日立製作所 | 微粒子を用いたプローブアレーの作製方法及び装置 |
US6322683B1 (en) | 1999-04-14 | 2001-11-27 | Caliper Technologies Corp. | Alignment of multicomponent microfabricated structures |
US20040053290A1 (en) | 2000-01-11 | 2004-03-18 | Terbrueggen Robert Henry | Devices and methods for biochip multiplexing |
US7056661B2 (en) * | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
DE60014676T2 (de) | 1999-05-28 | 2005-11-17 | Cepheid, Sunnyvale | Vorrichtung und verfahren zur analyse flüssiger proben |
NZ516278A (en) * | 1999-06-22 | 2004-03-26 | Invitrogen Corp | Improved primers and methods for the detection and discrimination of nucleic acids |
US6899137B2 (en) | 1999-06-28 | 2005-05-31 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
US6818395B1 (en) | 1999-06-28 | 2004-11-16 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
US6929030B2 (en) | 1999-06-28 | 2005-08-16 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
KR100865105B1 (ko) | 1999-06-28 | 2008-10-24 | 캘리포니아 인스티튜트 오브 테크놀로지 | 마이크로 가공된 탄성중합체 밸브 및 펌프 시스템 |
US6533914B1 (en) | 1999-07-08 | 2003-03-18 | Shaorong Liu | Microfabricated injector and capillary array assembly for high-resolution and high throughput separation |
JP2003505059A (ja) | 1999-07-28 | 2003-02-12 | ジェンセット | 連続流マイクロ流体デバイスにおける生化学的プロトコルの集積化 |
US6977145B2 (en) | 1999-07-28 | 2005-12-20 | Serono Genetics Institute S.A. | Method for carrying out a biochemical protocol in continuous flow in a microreactor |
US6423536B1 (en) | 1999-08-02 | 2002-07-23 | Molecular Dynamics, Inc. | Low volume chemical and biochemical reaction system |
US6524456B1 (en) | 1999-08-12 | 2003-02-25 | Ut-Battelle, Llc | Microfluidic devices for the controlled manipulation of small volumes |
US6824663B1 (en) | 1999-08-27 | 2004-11-30 | Aclara Biosciences, Inc. | Efficient compound distribution in microfluidic devices |
US6846626B1 (en) * | 1999-09-01 | 2005-01-25 | Genome Technologies, Llc | Method for amplifying sequences from unknown DNA |
US20020151089A1 (en) | 1999-09-15 | 2002-10-17 | Chapman William H. | Separating components of biological samples |
US6623945B1 (en) | 1999-09-16 | 2003-09-23 | Motorola, Inc. | System and method for microwave cell lysing of small samples |
EP1218543A2 (de) | 1999-09-29 | 2002-07-03 | Solexa Ltd. | Polynukleotidsequenzierung |
WO2002037096A1 (en) | 1999-10-01 | 2002-05-10 | University Of California | Microfabricated liquid sample loading system |
JP3896739B2 (ja) * | 1999-10-29 | 2007-03-22 | 株式会社日立製作所 | キャピラリー電気泳動装置 |
US7329388B2 (en) | 1999-11-08 | 2008-02-12 | Princeton Biochemicals, Inc. | Electrophoresis apparatus having staggered passage configuration |
US6326068B1 (en) | 1999-11-08 | 2001-12-04 | Exxonmobil Oil Corporation | Multi-layer hermetically sealable film |
US6120184A (en) | 1999-11-17 | 2000-09-19 | Stone Container Corporation | Bag apparatus with reclosable pour spout |
CA2290731A1 (en) | 1999-11-26 | 2001-05-26 | D. Jed Harrison | Apparatus and method for trapping bead based reagents within microfluidic analysis system |
US6432290B1 (en) | 1999-11-26 | 2002-08-13 | The Governors Of The University Of Alberta | Apparatus and method for trapping bead based reagents within microfluidic analysis systems |
WO2001055454A1 (en) | 2000-01-28 | 2001-08-02 | Althea Technologies, Inc. | Methods for analysis of gene expression |
SE0000300D0 (sv) | 2000-01-30 | 2000-01-30 | Amersham Pharm Biotech Ab | Microfluidic assembly, covering method for the manufacture of the assembly and the use of the assembly |
US6807490B1 (en) | 2000-02-15 | 2004-10-19 | Mark W. Perlin | Method for DNA mixture analysis |
US7922984B2 (en) | 2000-02-18 | 2011-04-12 | Selective Micro Technologies, Llc | Apparatus and method for controlled delivery of a gas |
CA2400159A1 (en) | 2000-02-23 | 2001-08-30 | Zyomyx, Inc. | Chips having elevated sample surfaces |
EP1268696A4 (de) | 2000-02-28 | 2005-01-26 | Adsil Lc | Auf silan basierende beschichtungszusammensetzungen, dadurch erhältliche beschichtete gegenstände sowie verfahren zur verwendung derselben |
EP1269171B1 (de) | 2000-03-07 | 2006-05-31 | Northeastern University | Paralleles array unabhängiger thermostaten für säulentrennungen |
US6685678B2 (en) | 2000-03-22 | 2004-02-03 | Docusys, Inc. | Drug delivery and monitoring system |
WO2001072335A2 (en) | 2000-03-28 | 2001-10-04 | Queen's University At Kingston | Methods for effecting neuroprotection using a potassium channel modulator |
JP2001283190A (ja) | 2000-03-30 | 2001-10-12 | Fuji Photo Film Co Ltd | 画像処理装置 |
US7279146B2 (en) | 2003-04-17 | 2007-10-09 | Fluidigm Corporation | Crystal growth devices and systems, and methods for using same |
SE0001768D0 (sv) | 2000-05-12 | 2000-05-12 | Helen Andersson | Mikrofluidisk flödescell för manipulering av partiklar |
JP3918403B2 (ja) | 2000-05-15 | 2007-05-23 | 株式会社日立製作所 | キャピラリアレイ |
US6531282B1 (en) * | 2000-05-30 | 2003-03-11 | Oligotrail, Llc | Multiplex amplification and analysis of selected STR loci |
US7351376B1 (en) | 2000-06-05 | 2008-04-01 | California Institute Of Technology | Integrated active flux microfluidic devices and methods |
WO2002001081A2 (en) * | 2000-06-23 | 2002-01-03 | Micronics, Inc. | Valve for use in microfluidic structures |
US6885982B2 (en) | 2000-06-27 | 2005-04-26 | Fluidigm Corporation | Object oriented microfluidic design method and system |
AU2001273057A1 (en) * | 2000-06-27 | 2002-01-08 | Fluidigm Corporation | A microfluidic design automation method and system |
US6734401B2 (en) | 2000-06-28 | 2004-05-11 | 3M Innovative Properties Company | Enhanced sample processing devices, systems and methods |
US6531041B1 (en) * | 2000-07-20 | 2003-03-11 | Symyx Technologies, Inc. | Multiplexed capillary electrophoresis system with rotatable photodetector |
US7004184B2 (en) * | 2000-07-24 | 2006-02-28 | The Reagents Of The University Of Michigan | Compositions and methods for liquid metering in microchannels |
US20020048534A1 (en) | 2000-08-24 | 2002-04-25 | David Storek | Sample preparing arrangement and a method relating to such an arrangement |
US8048386B2 (en) | 2002-02-25 | 2011-11-01 | Cepheid | Fluid processing and control |
EP1978110B1 (de) | 2000-09-06 | 2010-05-26 | Transnetyx, Inc. | Computer-basiertes Verfahren und System zum Screenen von genomischer DNS |
EP2299256A3 (de) | 2000-09-15 | 2012-10-10 | California Institute Of Technology | Miniaturisierte Querstromvorrichtungen und -Verfahren |
WO2002024949A1 (fr) | 2000-09-22 | 2002-03-28 | Hitachi, Ltd. | Procede d'analyse d'acide nucleique |
EP1322936A2 (de) | 2000-10-03 | 2003-07-02 | California Institute Of Technology | Mikrofluidvorrichtungen und verwendungsverfahren |
US7097809B2 (en) | 2000-10-03 | 2006-08-29 | California Institute Of Technology | Combinatorial synthesis system |
US6782746B1 (en) | 2000-10-24 | 2004-08-31 | Sandia National Laboratories | Mobile monolithic polymer elements for flow control in microfluidic devices |
DE60001177T2 (de) | 2000-10-25 | 2003-10-23 | Bruker Biospin Gmbh | LC-NMR System, enthaltend eine Vorrichtung zum Einfangen von mindestens einer Komponente eines Chromatographieflusses |
CA2361980A1 (en) | 2000-11-13 | 2002-05-13 | Arkmount Systems Inc. | Heat sealing and cutting mechanism and container forming apparatus incorporating the same |
EP1345698A4 (de) | 2000-11-16 | 2006-05-17 | Fluidigm Corp | Mikrofluidvorrichtungen zur einleitung und abgabe von fluiden aus mikrofluidsystemen |
US6521188B1 (en) | 2000-11-22 | 2003-02-18 | Industrial Technology Research Institute | Microfluidic actuator |
US6527003B1 (en) * | 2000-11-22 | 2003-03-04 | Industrial Technology Research | Micro valve actuator |
SE0004351D0 (sv) | 2000-11-27 | 2000-11-27 | Helen Andersson | System och metod för tidstyrd vätskehantering för reaktioner och processer i ett mikrofluidiskt flödescellsystem |
US20020137039A1 (en) | 2000-12-22 | 2002-09-26 | Baxter Aktiengesellschaft | 5' Nuclease nucleic acid amplification assay having an improved internal control |
US20020123538A1 (en) * | 2000-12-29 | 2002-09-05 | Peiguang Zhou | Hot-melt adhesive based on blend of amorphous and crystalline polymers for multilayer bonding |
US6767194B2 (en) * | 2001-01-08 | 2004-07-27 | President And Fellows Of Harvard College | Valves and pumps for microfluidic systems and method for making microfluidic systems |
US20020098097A1 (en) | 2001-01-22 | 2002-07-25 | Angad Singh | Magnetically-actuated micropump |
WO2002072264A1 (en) | 2001-03-09 | 2002-09-19 | Biomicro Systems, Inc. | Method and system for microfluidic interfacing to arrays |
US6852287B2 (en) | 2001-09-12 | 2005-02-08 | Handylab, Inc. | Microfluidic devices having a reduced number of input and output connections |
US6960437B2 (en) * | 2001-04-06 | 2005-11-01 | California Institute Of Technology | Nucleic acid amplification utilizing microfluidic devices |
US6752922B2 (en) | 2001-04-06 | 2004-06-22 | Fluidigm Corporation | Microfluidic chromatography |
US6802342B2 (en) | 2001-04-06 | 2004-10-12 | Fluidigm Corporation | Microfabricated fluidic circuit elements and applications |
ATE500051T1 (de) | 2001-04-06 | 2011-03-15 | Fluidigm Corp | Polymeroberflächenmodifikation |
AU2002359234B2 (en) | 2001-04-25 | 2007-11-15 | Cornell Research Foundation, Inc. | Devices and methods for pharmacokinetic-based cell culture system |
US7318912B2 (en) | 2001-06-07 | 2008-01-15 | Nanostream, Inc. | Microfluidic systems and methods for combining discrete fluid volumes |
US6629820B2 (en) | 2001-06-26 | 2003-10-07 | Micralyne Inc. | Microfluidic flow control device |
GB0119959D0 (en) * | 2001-08-16 | 2001-10-10 | Sec Dep Of The Home Department | Improvements in and relating to analysis |
US20040013536A1 (en) * | 2001-08-31 | 2004-01-22 | Hower Robert W | Micro-fluidic pump |
US20030095897A1 (en) * | 2001-08-31 | 2003-05-22 | Grate Jay W. | Flow-controlled magnetic particle manipulation |
JP2003074462A (ja) | 2001-09-03 | 2003-03-12 | Fukuoka Institute Of Technology | 磁性流体ポンプ |
JP4381670B2 (ja) | 2001-10-30 | 2009-12-09 | 株式会社日立製作所 | 反応装置 |
WO2003040395A2 (en) * | 2001-11-07 | 2003-05-15 | Applera Corporation | Universal nucleotides for nucleic acid analysis |
US20030087425A1 (en) | 2001-11-07 | 2003-05-08 | Eggers Mitchell D | Sample carrier |
US7584240B2 (en) | 2001-11-07 | 2009-09-01 | Genvault Corporation | Automated biological sample archive for storage, retrieval and analysis of large numbers of samples for remote clients |
US7142987B2 (en) | 2001-11-07 | 2006-11-28 | Genvault Corporation | Apparatus, system, and method of archival and retrieval of samples |
US20030129755A1 (en) | 2001-11-07 | 2003-07-10 | Genvault Corporation | System and method of storing and retrieving storage elements |
US20030087455A1 (en) | 2001-11-07 | 2003-05-08 | Eggers Mitchell D | Sample carrier system |
JP4355210B2 (ja) * | 2001-11-30 | 2009-10-28 | フルイディグム コーポレイション | 微小流体デバイスおよび微小流体デバイスの使用方法 |
US7691333B2 (en) | 2001-11-30 | 2010-04-06 | Fluidigm Corporation | Microfluidic device and methods of using same |
US6864480B2 (en) * | 2001-12-19 | 2005-03-08 | Sau Lan Tang Staats | Interface members and holders for microfluidic array devices |
US6532997B1 (en) | 2001-12-28 | 2003-03-18 | 3M Innovative Properties Company | Sample processing device with integral electrophoresis channels |
EP1468116A2 (de) | 2002-01-16 | 2004-10-20 | Dynal Biotech ASA | Verfahren zur isolierung von nukleinsäuren und proteinen aus einer einzigen probe |
US7846315B2 (en) * | 2002-01-28 | 2010-12-07 | Qiagen Sciences, Llc | Integrated bio-analysis and sample preparation system |
US6581441B1 (en) | 2002-02-01 | 2003-06-24 | Perseptive Biosystems, Inc. | Capillary column chromatography process and system |
WO2003068402A1 (en) | 2002-02-13 | 2003-08-21 | Nanostream, Inc. | Microfluidic separation column devices and fabrication methods |
US6685442B2 (en) | 2002-02-20 | 2004-02-03 | Sandia National Laboratories | Actuator device utilizing a conductive polymer gel |
AU2003218114B2 (en) | 2002-03-11 | 2008-09-18 | Athenix Corporation | Integrated system for high throughput capture of genetic diversity |
WO2003085379A2 (en) | 2002-04-01 | 2003-10-16 | Fluidigm Corporation | Microfluidic particle-analysis systems |
US7312085B2 (en) | 2002-04-01 | 2007-12-25 | Fluidigm Corporation | Microfluidic particle-analysis systems |
EP2302389B1 (de) | 2002-05-09 | 2018-01-24 | The University of Chicago | Einrichtung und Verfahren für Druckgesteuerten Plug-Transport und Reaktion |
US20030215369A1 (en) | 2002-05-17 | 2003-11-20 | Eggers Mitchell D. | Sample carrier receiver |
US20030217923A1 (en) | 2002-05-24 | 2003-11-27 | Harrison D. Jed | Apparatus and method for trapping bead based reagents within microfluidic analysis systems |
US20040101444A1 (en) | 2002-07-15 | 2004-05-27 | Xeotron Corporation | Apparatus and method for fluid delivery to a hybridization station |
US6786708B2 (en) | 2002-07-18 | 2004-09-07 | The Regents Of The University Of Michigan | Laminated devices and methods of making same |
US20040018611A1 (en) * | 2002-07-23 | 2004-01-29 | Ward Michael Dennis | Microfluidic devices for high gradient magnetic separation |
WO2004011681A1 (en) | 2002-07-26 | 2004-02-05 | Applera Corporation | Microfluidic device including purification column with excess diluent, and method |
US7198759B2 (en) | 2002-07-26 | 2007-04-03 | Applera Corporation | Microfluidic devices, methods, and systems |
ATE358533T1 (de) | 2002-08-02 | 2007-04-15 | Ge Healthcare Sv Corp | Integriertes mikrochip-design |
US7244961B2 (en) * | 2002-08-02 | 2007-07-17 | Silicon Valley Scientific | Integrated system with modular microfluidic components |
US20040038385A1 (en) * | 2002-08-26 | 2004-02-26 | Langlois Richard G. | System for autonomous monitoring of bioagents |
US20040197845A1 (en) | 2002-08-30 | 2004-10-07 | Arjang Hassibi | Methods and apparatus for pathogen detection, identification and/or quantification |
US7605002B2 (en) | 2002-09-06 | 2009-10-20 | Epigem Limited | Modular microfluidic system |
US7157228B2 (en) * | 2002-09-09 | 2007-01-02 | Bioarray Solutions Ltd. | Genetic analysis and authentication |
JP3725109B2 (ja) | 2002-09-19 | 2005-12-07 | 財団法人生産技術研究奨励会 | マイクロ流体デバイス |
TW590982B (en) | 2002-09-27 | 2004-06-11 | Agnitio Science & Technology I | Micro-fluid driving device |
JP5695287B2 (ja) | 2002-10-02 | 2015-04-01 | カリフォルニア インスティテュート オブ テクノロジー | 微小流体の核酸解析 |
US7217542B2 (en) * | 2002-10-31 | 2007-05-15 | Hewlett-Packard Development Company, L.P. | Microfluidic system for analyzing nucleic acids |
US7932098B2 (en) * | 2002-10-31 | 2011-04-26 | Hewlett-Packard Development Company, L.P. | Microfluidic system utilizing thin-film layers to route fluid |
US20040086872A1 (en) | 2002-10-31 | 2004-05-06 | Childers Winthrop D. | Microfluidic system for analysis of nucleic acids |
US7718442B2 (en) | 2002-11-22 | 2010-05-18 | Genvault Corporation | Sealed sample storage element system and method |
JP2004180594A (ja) | 2002-12-04 | 2004-07-02 | Shimadzu Corp | 細胞培養装置 |
AU2003298938A1 (en) | 2002-12-05 | 2004-06-30 | Protasis Corporation | Configurable microfluidic substrate assembly |
WO2004055646A2 (en) * | 2002-12-13 | 2004-07-01 | Gene Codes Forensics, Inc. | Method for profiling and identifying persons by using data samples |
US20050266582A1 (en) | 2002-12-16 | 2005-12-01 | Modlin Douglas N | Microfluidic system with integrated permeable membrane |
JP2006512092A (ja) | 2002-12-30 | 2006-04-13 | ザ・リージェンツ・オブ・ジ・ユニバーシティ・オブ・カリフォルニア | 病原体の検出および分析のための方法および装置 |
US7049558B2 (en) * | 2003-01-27 | 2006-05-23 | Arcturas Bioscience, Inc. | Apparatus and method for heating microfluidic volumes and moving fluids |
US7575865B2 (en) | 2003-01-29 | 2009-08-18 | 454 Life Sciences Corporation | Methods of amplifying and sequencing nucleic acids |
DE602004024034D1 (de) | 2003-01-29 | 2009-12-24 | 454 Corp | Nukleinsäureamplifikation auf basis von kügelchenemulsion |
WO2004067162A2 (en) * | 2003-01-30 | 2004-08-12 | Ciphergen Biosystems Inc. | Apparatus for microfluidic processing and reading of biochip arrays |
US7718421B2 (en) * | 2003-02-05 | 2010-05-18 | Iquum, Inc. | Sample processing |
US7476363B2 (en) | 2003-04-03 | 2009-01-13 | Fluidigm Corporation | Microfluidic devices and methods of using same |
US7745116B2 (en) * | 2003-04-08 | 2010-06-29 | Pacific Biosciences Of California, Inc. | Composition and method for nucleic acid sequencing |
CA2515850A1 (en) * | 2003-04-14 | 2004-10-28 | Caliper Life Sciences, Inc. | Reduction of migration shift assay interference |
US20100075858A1 (en) | 2003-04-29 | 2010-03-25 | Genvault Corporation | Biological bar code |
US20050026181A1 (en) | 2003-04-29 | 2005-02-03 | Genvault Corporation | Bio bar-code |
US20040219533A1 (en) | 2003-04-29 | 2004-11-04 | Jim Davis | Biological bar code |
WO2004098757A2 (en) | 2003-05-06 | 2004-11-18 | New Jersey Institute Of Technology | Microfluidic mixing using flow pulsing |
WO2005007852A2 (en) | 2003-07-09 | 2005-01-27 | Genvault Corporation | Room temperature elution of nucleic acids |
US7943393B2 (en) | 2003-07-14 | 2011-05-17 | Phynexus, Inc. | Method and device for extracting an analyte |
US7357898B2 (en) * | 2003-07-31 | 2008-04-15 | Agency For Science, Technology And Research | Microfluidics packages and methods of using same |
US20050047967A1 (en) | 2003-09-03 | 2005-03-03 | Industrial Technology Research Institute | Microfluidic component providing multi-directional fluid movement |
TW200702660A (en) | 2003-11-21 | 2007-01-16 | Ebara Corp | Microfluidic treatment method and device |
US7939249B2 (en) * | 2003-12-24 | 2011-05-10 | 3M Innovative Properties Company | Methods for nucleic acid isolation and kits using a microfluidic device and concentration step |
DE602005020249D1 (de) | 2004-02-02 | 2010-05-12 | Silicon Valley Scient Inc | Integriertes system mit modularen mikrofluidischen komponenten |
US8043849B2 (en) | 2004-02-24 | 2011-10-25 | Thermal Gradient | Thermal cycling device |
CN1942222B (zh) | 2004-03-05 | 2011-08-31 | 麦克罗斯塔克公司 | 用于形成微阀的选择性接合 |
US7077175B2 (en) | 2004-04-09 | 2006-07-18 | Hongfeng Yin | Particle packing of microdevice |
CA2994321C (en) | 2004-05-03 | 2023-08-08 | Handylab, Inc. | A microfluidic device and methods for processing polynucleotide-containing samples |
JP4683538B2 (ja) | 2004-05-06 | 2011-05-18 | セイコーインスツル株式会社 | 分析用マイクロチップを含む分析システムと分析方法 |
JP3952036B2 (ja) | 2004-05-13 | 2007-08-01 | コニカミノルタセンシング株式会社 | マイクロ流体デバイス並びに試液の試験方法および試験システム |
PT1773978E (pt) | 2004-05-19 | 2014-05-29 | Massachusetts Inst Technology | Modelo de doença com células/tecidos tri-dimensionais perfundidos |
WO2005116081A2 (en) | 2004-05-24 | 2005-12-08 | Genvault Corporation | Stable protein storage and stable nucleic acid storage in recoverable form |
JP4372616B2 (ja) | 2004-05-28 | 2009-11-25 | アイダエンジニアリング株式会社 | マイクロバルブ、マイクロポンプ及びこれらを内蔵するマイクロチップ |
US7799553B2 (en) | 2004-06-01 | 2010-09-21 | The Regents Of The University Of California | Microfabricated integrated DNA analysis system |
US20050272144A1 (en) | 2004-06-08 | 2005-12-08 | Konica Minolta Medical & Graphic, Inc. | Micro-reactor for improving efficiency of liquid mixing and reaction |
US20060057209A1 (en) | 2004-09-16 | 2006-03-16 | Predicant Biosciences, Inc. | Methods, compositions and devices, including microfluidic devices, comprising coated hydrophobic surfaces |
JP5249581B2 (ja) | 2004-08-09 | 2013-07-31 | ジェネレイション バイオテック リミテッド ライアビリティ カンパニー | 核酸の単離および増幅方法 |
EP2261650A3 (de) | 2004-09-15 | 2011-07-06 | IntegenX Inc. | Mikrofluidische Vorrichtungen |
GB0421529D0 (en) | 2004-09-28 | 2004-10-27 | Landegren Gene Technology Ab | Microfluidic structure |
US7832429B2 (en) * | 2004-10-13 | 2010-11-16 | Rheonix, Inc. | Microfluidic pump and valve structures and fabrication methods |
WO2006044458A2 (en) * | 2004-10-13 | 2006-04-27 | University Of Virginia Patent Foundation | Electrostatic actuation for management of flow |
US7608160B2 (en) * | 2004-10-13 | 2009-10-27 | Rheonix, Inc. | Laminated microfluidic structures and method for making |
WO2006054689A1 (ja) * | 2004-11-22 | 2006-05-26 | Nissui Pharmaceutical Co., Ltd. | マイクロチップ |
KR100634525B1 (ko) * | 2004-11-23 | 2006-10-16 | 삼성전자주식회사 | 복수 개의 전자석이 배치되어 있는 마이크로채널을포함하는 미세유동 장치, 그를 이용하여 시료를 혼합하는방법 및 세포를 용해하는 방법 |
WO2006071470A2 (en) * | 2004-12-03 | 2006-07-06 | California Institute Of Technology | Microfluidic devices with chemical reaction circuits |
US8883487B2 (en) | 2004-12-23 | 2014-11-11 | Abbott Point Of Care Inc. | Molecular diagnostics system and methods |
US20100010472A1 (en) | 2004-12-24 | 2010-01-14 | Ian Marshall Moore | Safety syringe |
US20060163143A1 (en) | 2005-01-26 | 2006-07-27 | Chirica Gabriela S | Microliter scale solid phase extraction devices |
CA2496481A1 (en) | 2005-02-08 | 2006-08-09 | Mds Inc., Doing Business Through It's Mds Sciex Division | Method and apparatus for sample deposition |
US7407757B2 (en) | 2005-02-10 | 2008-08-05 | Population Genetics Technologies | Genetic analysis by sequence-specific sorting |
JP3921233B2 (ja) | 2005-02-10 | 2007-05-30 | 松下電器産業株式会社 | 流体チップ、それを用いた流体移動制御方法、および化学反応装置 |
US20060210994A1 (en) | 2005-03-15 | 2006-09-21 | Joyce Timothy H | Microfluidic systems and methods for using microfluidic devices |
US20060210998A1 (en) | 2005-03-18 | 2006-09-21 | Christiane Kettlitz | Determination of antibiotic resistance in staphylococcus aureus |
US20070017812A1 (en) | 2005-03-30 | 2007-01-25 | Luc Bousse | Optimized Sample Injection Structures in Microfluidic Separations |
US20070015179A1 (en) * | 2005-04-26 | 2007-01-18 | Trustees Of Boston University | Plastic microfluidic chip and methods for isolation of nucleic acids from biological samples |
US20070020654A1 (en) | 2005-05-19 | 2007-01-25 | Affymetrix, Inc. | Methods and kits for preparing nucleic acid samples |
US20060263789A1 (en) | 2005-05-19 | 2006-11-23 | Robert Kincaid | Unique identifiers for indicating properties associated with entities to which they are attached, and methods for using |
US8206974B2 (en) | 2005-05-19 | 2012-06-26 | Netbio, Inc. | Ruggedized apparatus for analysis of nucleic acid and proteins |
US7316766B2 (en) | 2005-05-27 | 2008-01-08 | Taidoc Technology Corporation | Electrochemical biosensor strip |
WO2007002579A2 (en) | 2005-06-23 | 2007-01-04 | Bioveris Corporation | Assay cartridges and methods for point of care instruments |
US7817273B2 (en) | 2005-06-30 | 2010-10-19 | Life Technologies Corporation | Two-dimensional spectral imaging system |
US20070031865A1 (en) * | 2005-07-07 | 2007-02-08 | David Willoughby | Novel Process for Construction of a DNA Library |
US20080219889A1 (en) * | 2005-08-19 | 2008-09-11 | Koninklijke Philips Electronics, N.V. | System for Automatically Processing a Biological Sample |
US20070184463A1 (en) | 2005-09-30 | 2007-08-09 | Caliper Life Sciences, Inc. | Microfluidic device for purifying a biological component using magnetic beads |
CN101317086B (zh) * | 2005-10-04 | 2013-08-14 | 海德威技术公司 | 分析物的微观流体检测 |
WO2007044917A2 (en) | 2005-10-11 | 2007-04-19 | Handylab, Inc. | Polynucleotide sample preparation device |
US7709544B2 (en) | 2005-10-25 | 2010-05-04 | Massachusetts Institute Of Technology | Microstructure synthesis by flow lithography and polymerization |
US20080311585A1 (en) | 2005-11-02 | 2008-12-18 | Affymetrix, Inc. | System and method for multiplex liquid handling |
US20070122819A1 (en) | 2005-11-25 | 2007-05-31 | Industrial Technology Research Institute | Analyte assay structure in microfluidic chip for quantitative analysis and method for using the same |
US7763453B2 (en) | 2005-11-30 | 2010-07-27 | Micronics, Inc. | Microfluidic mixing and analytic apparatus |
US20080179255A1 (en) * | 2007-01-29 | 2008-07-31 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Fluidic devices |
JP4593451B2 (ja) | 2005-12-05 | 2010-12-08 | セイコーインスツル株式会社 | マイクロリアクターシステム及び送液方法 |
CN101004423B (zh) | 2006-01-19 | 2011-12-28 | 博奥生物有限公司 | 流体样品分析用卡盒系统 |
US7976795B2 (en) | 2006-01-19 | 2011-07-12 | Rheonix, Inc. | Microfluidic systems |
JP2007198765A (ja) * | 2006-01-24 | 2007-08-09 | Toray Ind Inc | 分析チップおよび分析方法 |
US7749365B2 (en) | 2006-02-01 | 2010-07-06 | IntegenX, Inc. | Optimized sample injection structures in microfluidic separations |
WO2007106579A2 (en) * | 2006-03-15 | 2007-09-20 | Micronics, Inc. | Integrated nucleic acid assays |
US7766033B2 (en) | 2006-03-22 | 2010-08-03 | The Regents Of The University Of California | Multiplexed latching valves for microfluidic devices and processors |
US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
DK3088083T3 (en) | 2006-03-24 | 2018-11-26 | Handylab Inc | Method of carrying out PCR down a multi-track cartridge |
US9063132B2 (en) * | 2006-03-29 | 2015-06-23 | Inverness Medical Switzerland Gmbh | Assay device and method |
KR100785010B1 (ko) | 2006-04-06 | 2007-12-11 | 삼성전자주식회사 | 수소 결합을 이용하여 고체 지지체의 친수성 표면 상에서핵산 정제 방법 및 장치 |
EP2530168B1 (de) * | 2006-05-11 | 2015-09-16 | Raindance Technologies, Inc. | Mikrofluidische Vorrichtungen |
WO2007136840A2 (en) * | 2006-05-20 | 2007-11-29 | Codon Devices, Inc. | Nucleic acid library design and assembly |
US8296088B2 (en) | 2006-06-02 | 2012-10-23 | Luminex Corporation | Systems and methods for performing measurements of one or more materials |
US8137912B2 (en) * | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
AU2007265628B2 (en) * | 2006-06-23 | 2012-12-06 | Perkinelmer Health Sciences, Inc. | Methods and devices for microfluidic point-of-care immunoassays |
US8337777B2 (en) | 2006-06-28 | 2012-12-25 | Applied Biosystems, Llc | Sample distribution devices and methods |
US7629124B2 (en) | 2006-06-30 | 2009-12-08 | Canon U.S. Life Sciences, Inc. | Real-time PCR in micro-channels |
AU2007278425B2 (en) | 2006-07-28 | 2011-11-17 | Qiagen Gmbh | Device for processing samples |
WO2008024319A2 (en) | 2006-08-20 | 2008-02-28 | Codon Devices, Inc. | Microfluidic devices for nucleic acid assembly |
WO2008147382A1 (en) | 2006-09-27 | 2008-12-04 | Micronics, Inc. | Integrated microfluidic assay devices and methods |
US20080131327A1 (en) | 2006-09-28 | 2008-06-05 | California Institute Of Technology | System and method for interfacing with a microfluidic chip |
WO2008052138A2 (en) | 2006-10-25 | 2008-05-02 | The Regents Of The University Of California | Inline-injection microdevice and microfabricated integrated dna analysis system using same |
US20080242560A1 (en) | 2006-11-21 | 2008-10-02 | Gunderson Kevin L | Methods for generating amplified nucleic acid arrays |
US8691592B2 (en) * | 2006-12-14 | 2014-04-08 | The Trustees Of The University Of Pennsylvania | Mechanically actuated diagnostic device |
CA2672315A1 (en) | 2006-12-14 | 2008-06-26 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes using large scale fet arrays |
US8409877B2 (en) * | 2006-12-29 | 2013-04-02 | Intel Corporation | Enzymatic signal generation and detection of binding complexes in stationary fluidic chip |
EP2121983A2 (de) | 2007-02-02 | 2009-11-25 | Illumina Cambridge Limited | Verfahren zur kennzeichnung von proben und sequenzierung mehrerer nukleotidmatrizen |
WO2008115626A2 (en) | 2007-02-05 | 2008-09-25 | Microchip Biotechnologies, Inc. | Microfluidic and nanofluidic devices, systems, and applications |
US8877518B2 (en) * | 2007-02-06 | 2014-11-04 | The Trustees Of The University Of Pennsylvania | Multiplexed nanoscale electrochemical sensors for multi-analyte detection |
US20080241844A1 (en) | 2007-02-06 | 2008-10-02 | Network Biosystems, Inc. | Devices and Methods for the Performance of Miniaturized In Vitro Assays |
WO2011084703A2 (en) | 2009-12-21 | 2011-07-14 | Advanced Liquid Logic, Inc. | Enzyme assays on a droplet actuator |
CA2682734C (en) | 2007-04-04 | 2017-11-07 | Network Biosystems, Inc. | Plastic microfluidic separation and detection platforms |
US8702976B2 (en) | 2007-04-18 | 2014-04-22 | Ondavia, Inc. | Hand-held microfluidic testing device |
ATE554859T1 (de) | 2007-05-24 | 2012-05-15 | Univ California | Integrierte fluidische vorrichtungen mit magnetischer sortierung |
US20100111770A1 (en) * | 2007-06-07 | 2010-05-06 | Samsung Electronics Co., Ltd. | Microfluidic Chip and Method of Fabricating The Same |
ATE555836T1 (de) | 2007-06-29 | 2012-05-15 | Harvard College | Materialtrennungsverfahren auf dichtebasis, überwachung feststoffunterstützter reaktionen und messung der dichte kleiner flüssigkeitsvolumina und feststoffe |
JPWO2009008236A1 (ja) | 2007-07-10 | 2010-09-02 | コニカミノルタエムジー株式会社 | マイクロ検査チップの液体混合方法および検査装置 |
US9618139B2 (en) * | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
WO2009015296A1 (en) | 2007-07-24 | 2009-01-29 | The Regents Of The University Of California | Microfabricated dropley generator |
US7744737B1 (en) | 2007-07-26 | 2010-06-29 | Sandia Corporation | Microfluidic device for the assembly and transport of microparticles |
DE102007035721B4 (de) | 2007-07-30 | 2019-02-07 | Robert Bosch Gmbh | Mikroventil, Verfahren zum Herstellen eines Mikroventils sowie Mikropumpe |
WO2009020435A1 (en) * | 2007-08-07 | 2009-02-12 | Agency For Science, Technology And Research | Integrated microfluidic device for gene synthesis |
GB2464433B (en) * | 2007-08-23 | 2012-06-20 | Cynvenio Biosystems Llc | Trapping magnetic sorting system for target species |
WO2009032645A1 (en) | 2007-09-06 | 2009-03-12 | Siemens Healthcare Diagnostics, Inc. | Reagent cartridge |
EP2214823A1 (de) * | 2007-11-26 | 2010-08-11 | Atonomics A/S | Integrierte trenn- und nachweiskartusche mit vorrichtung und verfahren zur erhöhung des signal-rausch-verhältnisses |
EP2234916A4 (de) | 2008-01-22 | 2016-08-10 | Integenx Inc | Universelles probenpräparationssystem und seine verwendung in einem integrierten analysesystem |
WO2009117611A2 (en) * | 2008-03-19 | 2009-09-24 | Cynvenio Biosystems, Llc | Trapping magnetic cell sorting system |
EP2271919A1 (de) * | 2008-04-16 | 2011-01-12 | Cynvenio Biosystems, Inc. | Magnetisches trennsystem mit vor- und nachbearbeitungsmodulen |
US7867713B2 (en) * | 2008-04-21 | 2011-01-11 | Lawrence Livermore National Security, Llc | Polymerase chain reaction system using magnetic beads for analyzing a sample that includes nucleic acid |
US20090269504A1 (en) | 2008-04-24 | 2009-10-29 | Momentive Performance Materials Inc. | Flexible hardcoats and substrates coated therewith |
KR100960066B1 (ko) | 2008-05-14 | 2010-05-31 | 삼성전자주식회사 | 동결건조시약이 저장된 미세유동장치 및 이를 이용한시료분석방법 |
US8323568B2 (en) | 2008-06-13 | 2012-12-04 | Honeywell International Inc. | Magnetic bead assisted sample conditioning system |
US8795607B2 (en) * | 2008-06-19 | 2014-08-05 | Boehringer Ingelheim Microparts Gmbh | Fluid metering container |
US8092761B2 (en) | 2008-06-20 | 2012-01-10 | Silverbrook Research Pty Ltd | Mechanically-actuated microfluidic diaphragm valve |
US7976789B2 (en) | 2008-07-22 | 2011-07-12 | The Board Of Trustees Of The University Of Illinois | Microfluidic device for preparing mixtures |
US8617488B2 (en) | 2008-08-07 | 2013-12-31 | Fluidigm Corporation | Microfluidic mixing and reaction systems for high efficiency screening |
CN102159726A (zh) * | 2008-09-05 | 2011-08-17 | 生命科技公司 | 用于核酸测序验证、校准和标准化的方法和系统 |
WO2010031007A2 (en) | 2008-09-12 | 2010-03-18 | Genvault Corporation | Matrices and media for storage and stabilization of biomolecules |
RU2500478C2 (ru) | 2008-10-06 | 2013-12-10 | Конинклейке Филипс Электроникс Н.В. | Микрожидкостное устройство |
JP2012504956A (ja) | 2008-10-10 | 2012-03-01 | セントレ ナショナル デ ラ レシェルシェ サイエンティフィーク−ディーエーイー | 細胞ソート・デバイス |
US9422409B2 (en) | 2008-10-10 | 2016-08-23 | Massachusetts Institute Of Technology | Method of hydrolytically stable bonding of elastomers to substrates |
WO2010054000A1 (en) | 2008-11-04 | 2010-05-14 | Richard Joseph | Methods, flow cells and systems for single cell analysis |
CN102341691A (zh) | 2008-12-31 | 2012-02-01 | 尹特根埃克斯有限公司 | 具有微流体芯片的仪器 |
EP2394152B1 (de) | 2009-02-03 | 2019-05-01 | ANDE Corporation | Nukleinsäureaufreinigung |
WO2010091406A2 (en) | 2009-02-09 | 2010-08-12 | Forensic Science Service Limited | Improvements in and relating to devices |
CN102362183B (zh) | 2009-03-23 | 2014-11-05 | 皇家飞利浦电子股份有限公司 | 生物样本中磁性颗粒的操控 |
US20100243916A1 (en) | 2009-03-30 | 2010-09-30 | Lockheed Martin Corporation | Modular optical diagnostic platform for chemical and biological target diagnosis and detection |
WO2010129937A2 (en) * | 2009-05-08 | 2010-11-11 | Life Technologies Corporation | Methods for detecting genetic variations in dna samples |
GB2473868A (en) | 2009-09-28 | 2011-03-30 | Invitrogen Dynal As | Apparatus and method of automated processing of biological samples |
EP2438154A1 (de) | 2009-06-02 | 2012-04-11 | Integenx Inc. | Fluidische vorrichtung mit membranventilen |
AU2010257118B2 (en) | 2009-06-04 | 2014-08-28 | Lockheed Martin Corporation | Multiple-sample microfluidic chip for DNA analysis |
KR20120031218A (ko) | 2009-06-05 | 2012-03-30 | 인터젠엑스 인크. | 만능 샘플 제조 시스템 및 집적 분석 시스템에서의 사용 |
EP2443254A2 (de) | 2009-06-15 | 2012-04-25 | NetBio, Inc. | Verbesserte verfahren für forensische dna-quantifizierung |
WO2011003941A1 (en) | 2009-07-07 | 2011-01-13 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Device for detection of biological agents |
US20120164036A1 (en) | 2009-07-21 | 2012-06-28 | Seth Stern | Microfluidic devices and uses thereof |
US8551787B2 (en) * | 2009-07-23 | 2013-10-08 | Fluidigm Corporation | Microfluidic devices and methods for binary mixing |
GB2472236A (en) | 2009-07-29 | 2011-02-02 | Iti Scotland Ltd | Apparatus for analysing microfluidic devices |
JP2013505018A (ja) | 2009-09-21 | 2013-02-14 | アコーニ バイオシステムズ | 磁気溶解方法及び装置 |
TWI421495B (zh) * | 2009-10-30 | 2014-01-01 | Univ Nat Cheng Kung | 微流體晶片 |
EP2496716A1 (de) | 2009-11-03 | 2012-09-12 | University Of Virginia Patent Foundation | Vielseitiges sichtbares verfahren für den nachweis von polymeranalyten |
US8584703B2 (en) | 2009-12-01 | 2013-11-19 | Integenx Inc. | Device with diaphragm valve |
DK2539472T3 (da) | 2010-02-26 | 2015-08-24 | Hennessy Lori | Hurtig pcr til str genotypebestemmelse |
US8720036B2 (en) | 2010-03-09 | 2014-05-13 | Netbio, Inc. | Unitary biochip providing sample-in to results-out processing and methods of manufacture |
US20110240127A1 (en) | 2010-04-02 | 2011-10-06 | Integenx Inc. | Fluidic Article Fabricated In One Piece |
CN102947082B (zh) | 2010-04-06 | 2016-03-30 | 金沃特公司 | 生物材料的稳定化的化学脱水 |
WO2011130280A1 (en) | 2010-04-12 | 2011-10-20 | Genvault Corporation | Products and methods for tissue preservation |
US8512538B2 (en) | 2010-05-28 | 2013-08-20 | Integenx Inc. | Capillary electrophoresis device |
WO2012024658A2 (en) | 2010-08-20 | 2012-02-23 | IntegenX, Inc. | Integrated analysis system |
WO2012024657A1 (en) | 2010-08-20 | 2012-02-23 | IntegenX, Inc. | Microfluidic devices with mechanically-sealed diaphragm valves |
EP2635706B1 (de) | 2010-11-05 | 2015-04-01 | Centre Hospitalier Universitaire Vaudois | Verfahren zum nachweis der anwesenheit eines dna-hauptkontributors in einem dna-gemisch |
WO2012097233A1 (en) | 2011-01-14 | 2012-07-19 | Integenx Inc. | Valves with hydraulic actuation system |
EP2689028B1 (de) | 2011-03-23 | 2017-08-30 | Pacific Biosciences Of California, Inc. | Isolierung von polymerase-nukleinsäurekomplexen und deren ladung auf substrate |
US9250229B2 (en) | 2011-09-25 | 2016-02-02 | Theranos, Inc. | Systems and methods for multi-analysis |
WO2013049071A1 (en) | 2011-09-26 | 2013-04-04 | Integenx Inc. | Methods and apparatuses for releasably fastening pins |
US20150136604A1 (en) | 2011-10-21 | 2015-05-21 | Integenx Inc. | Sample preparation, processing and analysis systems |
US8894946B2 (en) | 2011-10-21 | 2014-11-25 | Integenx Inc. | Sample preparation, processing and analysis systems |
US10865440B2 (en) | 2011-10-21 | 2020-12-15 | IntegenX, Inc. | Sample preparation, processing and analysis systems |
US9322054B2 (en) | 2012-02-22 | 2016-04-26 | Lockheed Martin Corporation | Microfluidic cartridge |
US20140065628A1 (en) | 2012-08-28 | 2014-03-06 | Integenx Inc. | Methods and Devices for Multi-Color, Out-of-Phase Detection in Electrophoresis |
US20140161686A1 (en) * | 2012-12-10 | 2014-06-12 | Advanced Liquid Logic, Inc. | System and method of dispensing liquids in a microfluidic device |
US10208332B2 (en) | 2014-05-21 | 2019-02-19 | Integenx Inc. | Fluidic cartridge with valve mechanism |
EP3209410A4 (de) | 2014-10-22 | 2018-05-02 | IntegenX Inc. | Systeme und verfahren zur automatisierten vorbereitung, verarbeitung und analyse von proben |
US10233491B2 (en) | 2015-06-19 | 2019-03-19 | IntegenX, Inc. | Valved cartridge and system |
US10633171B2 (en) | 2016-10-28 | 2020-04-28 | Lisec Austria Gmbh | Device and method for storing and/or for transporting insulating glass panes |
-
2010
- 2010-06-04 KR KR20127000333A patent/KR20120031218A/ko not_active Application Discontinuation
- 2010-06-04 SG SG2011089737A patent/SG176669A1/en unknown
- 2010-06-04 EP EP10784213.0A patent/EP2438016B1/de active Active
- 2010-06-04 JP JP2012514214A patent/JP2012529268A/ja active Pending
- 2010-06-04 BR BRPI1010169A patent/BRPI1010169A2/pt not_active Application Discontinuation
- 2010-06-04 EP EP18248079.8A patent/EP3586945A3/de active Pending
- 2010-06-04 CN CN201080034538.4A patent/CN102803147B/zh active Active
- 2010-06-04 WO PCT/US2010/037545 patent/WO2010141921A1/en active Application Filing
- 2010-06-04 RU RU2011151794/10A patent/RU2559541C2/ru active
- 2010-06-04 CA CA 2764464 patent/CA2764464A1/en not_active Abandoned
- 2010-06-04 AU AU2010256429A patent/AU2010256429B2/en active Active
- 2010-06-07 US US12/795,515 patent/US8394642B2/en active Active
-
2012
- 2012-12-17 US US13/717,585 patent/US8562918B2/en active Active
-
2013
- 2013-08-15 US US13/967,957 patent/US9012236B2/en active Active
-
2014
- 2014-11-24 US US14/552,389 patent/US9663819B2/en active Active
-
2015
- 2015-12-10 JP JP2015240839A patent/JP2016101166A/ja active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080164155A1 (en) * | 2003-01-31 | 2008-07-10 | Grant Pease | Microfluidic device with thin-film electronic devices |
US20070034025A1 (en) * | 2005-08-09 | 2007-02-15 | Cfd Research Corporation | Electrostatic sampler and method |
US20080014576A1 (en) * | 2006-02-03 | 2008-01-17 | Microchip Biotechnologies, Inc. | Microfluidic devices |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2749333C2 (ru) * | 2016-09-29 | 2021-06-08 | Байонир Корпорейшн | Устройство для обработки биологических образцов |
US11175300B2 (en) | 2016-09-29 | 2021-11-16 | Bioneer Corporation | Biological sample processing apparatus |
RU2659155C1 (ru) * | 2017-06-27 | 2018-06-28 | Ольга Владимировна Кондратенко | Способ сбора и первичного посева жидкости назального лаважа от пациентов с муковисцидозом для микробиологического исследования |
RU219829U1 (ru) * | 2022-12-22 | 2023-08-09 | Федеральное государственное автономное образовательное учреждение высшего образования "Российский национальный исследовательский медицинский университет имени Н.И. Пирогова" Министерства здравоохранения Российской Федерации (ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России) | Анализатор одноразового микрофлюидного картриджа |
Also Published As
Publication number | Publication date |
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SG176669A1 (en) | 2012-01-30 |
AU2010256429B2 (en) | 2015-09-17 |
KR20120031218A (ko) | 2012-03-30 |
CN102803147A (zh) | 2012-11-28 |
RU2011151794A (ru) | 2013-07-20 |
CA2764464A1 (en) | 2010-12-09 |
EP2438016A1 (de) | 2012-04-11 |
US20150136602A1 (en) | 2015-05-21 |
EP3586945A3 (de) | 2020-03-04 |
US9012236B2 (en) | 2015-04-21 |
CN102803147B (zh) | 2015-11-25 |
US20130224846A1 (en) | 2013-08-29 |
JP2012529268A (ja) | 2012-11-22 |
US20140170645A1 (en) | 2014-06-19 |
AU2010256429A1 (en) | 2011-12-22 |
US8394642B2 (en) | 2013-03-12 |
BRPI1010169A2 (pt) | 2016-03-29 |
EP3586945A2 (de) | 2020-01-01 |
JP2016101166A (ja) | 2016-06-02 |
US8562918B2 (en) | 2013-10-22 |
EP2438016B1 (de) | 2021-06-02 |
WO2010141921A1 (en) | 2010-12-09 |
US9663819B2 (en) | 2017-05-30 |
EP2438016A4 (de) | 2013-10-09 |
US20110005932A1 (en) | 2011-01-13 |
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