JP5401542B2 - 流体計量容器 - Google Patents
流体計量容器 Download PDFInfo
- Publication number
- JP5401542B2 JP5401542B2 JP2011513905A JP2011513905A JP5401542B2 JP 5401542 B2 JP5401542 B2 JP 5401542B2 JP 2011513905 A JP2011513905 A JP 2011513905A JP 2011513905 A JP2011513905 A JP 2011513905A JP 5401542 B2 JP5401542 B2 JP 5401542B2
- Authority
- JP
- Japan
- Prior art keywords
- film
- container
- chamber
- channel
- opening
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000012530 fluid Substances 0.000 title claims description 58
- 239000000463 material Substances 0.000 claims description 25
- 238000007789 sealing Methods 0.000 claims description 24
- 239000003153 chemical reaction reagent Substances 0.000 claims description 21
- 229920003023 plastic Polymers 0.000 claims description 21
- 239000004033 plastic Substances 0.000 claims description 20
- 229910052782 aluminium Inorganic materials 0.000 claims description 16
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 16
- 239000011888 foil Substances 0.000 claims description 14
- 229910052751 metal Inorganic materials 0.000 claims description 11
- 239000002184 metal Substances 0.000 claims description 11
- 238000000926 separation method Methods 0.000 claims description 11
- 239000002985 plastic film Substances 0.000 claims description 8
- 229920006255 plastic film Polymers 0.000 claims description 6
- 229920002725 thermoplastic elastomer Polymers 0.000 claims description 5
- 238000009792 diffusion process Methods 0.000 claims description 4
- 239000013013 elastic material Substances 0.000 claims description 4
- 238000007373 indentation Methods 0.000 claims description 2
- 229920001296 polysiloxane Polymers 0.000 claims description 2
- 229920001971 elastomer Polymers 0.000 claims 1
- 229920001973 fluoroelastomer Polymers 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000005060 rubber Substances 0.000 claims 1
- 239000010408 film Substances 0.000 description 233
- 239000007788 liquid Substances 0.000 description 51
- 239000000758 substrate Substances 0.000 description 19
- 239000000243 solution Substances 0.000 description 13
- 239000000853 adhesive Substances 0.000 description 12
- 230000001070 adhesive effect Effects 0.000 description 12
- 239000013039 cover film Substances 0.000 description 12
- 238000000034 method Methods 0.000 description 11
- 239000007789 gas Substances 0.000 description 10
- 230000008878 coupling Effects 0.000 description 9
- 238000010168 coupling process Methods 0.000 description 9
- 238000005859 coupling reaction Methods 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 8
- 239000002313 adhesive film Substances 0.000 description 7
- 239000010410 layer Substances 0.000 description 7
- 238000003466 welding Methods 0.000 description 6
- 230000007246 mechanism Effects 0.000 description 5
- 238000003825 pressing Methods 0.000 description 5
- 230000009471 action Effects 0.000 description 4
- 238000004026 adhesive bonding Methods 0.000 description 4
- 239000012790 adhesive layer Substances 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 239000012876 carrier material Substances 0.000 description 4
- 230000000149 penetrating effect Effects 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 229920001169 thermoplastic Polymers 0.000 description 4
- 239000004416 thermosoftening plastic Substances 0.000 description 4
- 239000004743 Polypropylene Substances 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 239000002131 composite material Substances 0.000 description 3
- 238000003475 lamination Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 229910000838 Al alloy Inorganic materials 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- -1 polypropylene Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 229920002449 FKM Polymers 0.000 description 1
- 125000002066 L-histidyl group Chemical group [H]N1C([H])=NC(C([H])([H])[C@](C(=O)[*])([H])N([H])[H])=C1[H] 0.000 description 1
- 229920001328 Polyvinylidene chloride Polymers 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000004070 electrodeposition Methods 0.000 description 1
- 238000004049 embossing Methods 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000002706 hydrostatic effect Effects 0.000 description 1
- 230000004941 influx Effects 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 230000007257 malfunction Effects 0.000 description 1
- 238000010297 mechanical methods and process Methods 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229920002493 poly(chlorotrifluoroethylene) Polymers 0.000 description 1
- 239000005023 polychlorotrifluoroethylene (PCTFE) polymer Substances 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000005033 polyvinylidene chloride Substances 0.000 description 1
- 238000006748 scratching Methods 0.000 description 1
- 230000002393 scratching effect Effects 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229920003051 synthetic elastomer Polymers 0.000 description 1
- 239000005061 synthetic rubber Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000003856 thermoforming Methods 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/505—Containers for the purpose of retaining a material to be analysed, e.g. test tubes flexible containers not provided for above
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0605—Metering of fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/16—Reagents, handling or storing thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
- B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/046—Function or devices integrated in the closure
- B01L2300/047—Additional chamber, reservoir
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0672—Integrated piercing tool
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
- B01L2300/123—Flexible; Elastomeric
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/14—Means for pressure control
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/1624—Destructible or deformable element controlled
- Y10T137/1632—Destructible element
- Y10T137/1692—Rupture disc
- Y10T137/1714—Direct pressure causes disc to burst
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/1624—Destructible or deformable element controlled
- Y10T137/1632—Destructible element
- Y10T137/1692—Rupture disc
- Y10T137/1714—Direct pressure causes disc to burst
- Y10T137/1729—Dome shape
Description
フィルムは、好ましくは、アルミニウムで作られ、ツール、例えばダイの作用によりフィルムを切断することができる。有利には、容器蓋としても見なすことができる第1のフィルムは、両面接着プラスチックストリップによって窪みのベースに取り付けられる。接着ストリップは、貫流開口部の付近に対応の凹部を更に有する。
2 キャリヤストリップ
3 第1のフィルム
4 容器チャンバ
5 接着層
6 第1の貫流開口部
7 第2のフィルム
8 非取付け領域
9 容器の縁部
10 第2の貫流開口部
11 溶接連結部
12 容器開口部
13 中間フィルム
14 支持体
15 第1のダイ
16 第2のダイ
17 マイクロフルイディックプラットホーム
18 入口開口部
19 支持平面
20 マイクロフルイディック器具
21 弁
22 カートリッジ
23 第1の取付け部
24 入れ物
25 分離部分
27 第2の取付け部
29 第3の取付け部
30 チャネル
35 容器チャネル
40 チャネル
Claims (20)
- 試薬を計量するための流体用容器(1)であって、チャンバ(4)と、前記流体を前記チャンバ(4)内に封入するよう前記チャンバ(4)を密閉する第1のフィルムとを有する容器(1)において、
第2のフィルム(7)が前記第1のフィルム(3)に密封的に被着され、前記フィルムは、圧力を両方のフィルムに同時に加えたとき、前記第1のフィルム(3)が裂け、前記第2のフィルム(7)が弾性的且つ/或いは可塑的に変形するよう前記フィルムの引裂き強さが互いに異なっている、
ことを特徴とする容器(1)。 - 前記チャンバ(4)は、キャリヤフィルム(2)に設けられた窪みである、
請求項1記載の容器(1)。 - チャネル(40)が前記チャンバ(4)に隣接して位置し、前記第1のフィルム(3)は、前記チャンバ(4)と前記チャネルとの間の流体分離部を形成している、
請求項1又は2記載の容器(1)。 - 前記第1のフィルム(3)は、金属箔である、
請求項1、2又は3記載の容器(1)。 - 前記第1のフィルム(3)は、アルミニウム箔である、
請求項4記載の容器(1)。 - 前記第1のフィルム(3)は、破断点伸びが50%未満のプラスチックから成る、
請求項1、2又は3記載の容器(1)。 - 前記プラスチックフィルム(3)は、前記チャンバの内部寄りに拡散防止層を有する、 請求項6記載の容器(1)。
- 前記第1のフィルム(3)は、厚さが5〜100ミクロン、好ましくは15〜100ミクロンである、
請求項4ないし7のいずれか1項に記載の容器(1)。 - 前記第2のフィルム(7)は、破断点伸びが300〜2000%、特に300〜700%、特に好ましくは400〜600%の弾性材料から成る、
請求項1ないし3のいずれか1項に記載の容器(1)。 - 前記第2のフィルム(7)のフィルム材料は、ゴムである、
請求項9記載の容器(1)。 - 前記第2のフィルム(7)のフィルム材料は、次の材料、即ち、
・TPE(熱可塑性エラストマー)
・シリコーン
・フッ素ゴム
・PVCのうちの1つである、
請求項9記載の容器(1)。 - 前記第1のフィルム(3)と前記チャンバ(4)との間には少なくとも1つの中間フィルム(13)が設けられ、該中間フィルムは、開口部(6)、特に貫通穴(6)を有する、
請求項1ないし11のいずれか1項に記載の容器(1)。 - 前記中間フィルム(13)は、プラスチックから成り、その厚さは、50〜1000ミクロンである、
請求項12記載の容器(1)。 - 前記チャンバ(4)は、ブリスタパック(2)に設けられた窪みである、
請求項1ないし13のいずれか1項に記載の容器(1)。 - 前記チャンバ(4)の壁は、プラスチック及び/又は金属から成る、
請求項14記載の容器(1)。 - 前記窪み(4)は、桶形又は楕円形であり、前記チャンバ(4)の前記チャンバ壁の外面を押して変形させることにより圧力を発生させることができる、
請求項14記載の容器(1)。 - 変形可能な、特に圧縮可能な前記チャンバ(4)の壁厚は、200〜300ミクロンである、
請求項16記載の容器(1)。 - 前記チャンバ(4)の容積は、100〜500マイクロリットル、特に200〜300マイクロリットルである、
請求項17記載の容器(1)。 - 前記第2のフィルム(7)は、その表面が前記第1のフィルム(3)に取り付けられ、前記フィルムの非取付け領域がチャネル(40)を形成するようになっている、
請求項3記載の容器(1)。 - 前記第1のフィルムは、材料を薄肉化した部分、特に切欠きの形態をした脆弱な箇所を有し、圧力を加えると、前記第1のフィルムは、前記脆弱な箇所のところが優先的に裂けるようになっている、
請求項1ないし19のいずれか1項に記載の容器(1)。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08011106.5 | 2008-06-19 | ||
EP08011106 | 2008-06-19 | ||
PCT/EP2009/003907 WO2009152952A1 (en) | 2008-06-19 | 2009-06-02 | Fluid metering container |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2011524313A JP2011524313A (ja) | 2011-09-01 |
JP2011524313A5 JP2011524313A5 (ja) | 2012-07-26 |
JP5401542B2 true JP5401542B2 (ja) | 2014-01-29 |
Family
ID=41130148
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011513905A Active JP5401542B2 (ja) | 2008-06-19 | 2009-06-02 | 流体計量容器 |
Country Status (5)
Country | Link |
---|---|
US (1) | US8795607B2 (ja) |
EP (1) | EP2300164B1 (ja) |
JP (1) | JP5401542B2 (ja) |
CN (1) | CN102105227B (ja) |
WO (1) | WO2009152952A1 (ja) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008030631A2 (en) | 2006-02-03 | 2008-03-13 | Microchip Biotechnologies, Inc. | Microfluidic devices |
SG176669A1 (en) * | 2009-06-05 | 2012-01-30 | Integenx Inc | Universal sample preparation system and use in an integrated analysis system |
JP2011149801A (ja) * | 2010-01-21 | 2011-08-04 | Yokogawa Electric Corp | 化学反応用カートリッジ |
WO2012024658A2 (en) | 2010-08-20 | 2012-02-23 | IntegenX, Inc. | Integrated analysis system |
WO2012062648A1 (de) * | 2010-11-10 | 2012-05-18 | Boehringer Ingelheim Microparts Gmbh | Blisterverpackung für flüssigkeit und deren verwendung sowie verfahren zum zuführen von flüssigkeit zu einer fluidischen anordnung |
EP2651766B1 (de) * | 2010-12-16 | 2015-03-11 | Boehringer Ingelheim Microparts GmbH | Verfahren zur befüllung einer kavität, insbesondere eines blisters einer blisterverpackung, mit einer flüssigkeit |
DE102011003856B4 (de) * | 2011-02-09 | 2020-06-18 | Robert Bosch Gmbh | Mikrosystem für fluidische Anwendungen sowie Herstellungsverfahren und Benutzungsverfahren für ein Mikrosystem für fluidische Anwendungen |
KR20140025380A (ko) | 2011-03-09 | 2014-03-04 | 픽셀 메디칼 테크놀러지즈 리미티드 | 분석용 세포함유 샘플유체를 준비하기 위한 일회용 카트리지 |
DE102011077101A1 (de) * | 2011-06-07 | 2012-12-13 | Robert Bosch Gmbh | Mikrofluidisches System und Verfahren zum Betreiben eines solchen Systems |
US8470153B2 (en) * | 2011-07-22 | 2013-06-25 | Tecan Trading Ag | Cartridge and system for manipulating samples in liquid droplets |
US8932543B2 (en) * | 2011-09-21 | 2015-01-13 | Sakura Finetek U.S.A., Inc. | Automated staining system and reaction chamber |
US10865440B2 (en) | 2011-10-21 | 2020-12-15 | IntegenX, Inc. | Sample preparation, processing and analysis systems |
US20150136604A1 (en) | 2011-10-21 | 2015-05-21 | Integenx Inc. | Sample preparation, processing and analysis systems |
CN103127971B (zh) * | 2011-12-02 | 2016-04-20 | 国家纳米科学中心 | 一种微流控管道及其制备方法 |
EP2799096A4 (en) * | 2011-12-31 | 2016-02-17 | Beijing Winsunny Harmony Science And Technology Co Ltd | URINE DRAINAGE DEVICE, DRAIN CONTROL DEVICE, DRAIN CONTROL SYSTEM, AND DRAINING METHOD |
CN103424356B (zh) * | 2012-05-21 | 2015-12-09 | 光宝科技股份有限公司 | 分析卡匣及其分析系统 |
EP2679307B1 (de) * | 2012-06-28 | 2015-08-12 | Thinxxs Microtechnology Ag | Mikrospeicher, insbesondere zur Integration in eine mikrofluidische Flusszelle |
US20150011396A1 (en) | 2012-07-09 | 2015-01-08 | Benjamin G. Schroeder | Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing |
JP5705329B2 (ja) * | 2012-07-24 | 2015-04-22 | パナソニックヘルスケアホールディングス株式会社 | 分析用デバイス |
US20140322706A1 (en) | 2012-10-24 | 2014-10-30 | Jon Faiz Kayyem | Integrated multipelx target analysis |
JP1628116S (ja) | 2012-10-24 | 2019-04-01 | ||
DE102012221848A1 (de) * | 2012-11-29 | 2014-06-05 | Robert Bosch Gmbh | Abgabe- und Dosiersystem, insbesondere von Substanzen in mikrofluidischen Systemen, sowie Verfahren und Kartusche mit dem Abgabe- und Dosiersystem |
DE102012222719A1 (de) * | 2012-12-11 | 2014-06-12 | Robert Bosch Gmbh | Folienbeutel zum Bevorraten eines Fluids und Vorrichtung zum Bereitstellen eines Fluids |
WO2014120998A1 (en) | 2013-01-31 | 2014-08-07 | Luminex Corporation | Fluid retention plates and analysis cartridges |
US20140255275A1 (en) * | 2013-03-07 | 2014-09-11 | Quidel Corporation | Dual chamber liquid packaging system |
WO2014159834A1 (en) * | 2013-03-14 | 2014-10-02 | Siemens Healthcare Diagnostics Inc. | Microfluidic chip with sealed on-board reagent |
US9453613B2 (en) | 2013-03-15 | 2016-09-27 | Genmark Diagnostics, Inc. | Apparatus, devices, and methods for manipulating deformable fluid vessels |
EP3046663A4 (en) * | 2013-09-18 | 2017-05-31 | California Institute of Technology | System and method for movement and timing control |
US20160236196A1 (en) * | 2013-09-30 | 2016-08-18 | Hitachi, Ltd. | Reagent Holding Container, Liquid Delivery Device, Reagent Discharge Method |
WO2015051347A2 (en) * | 2013-10-04 | 2015-04-09 | Avansci Bio, L.L.C. | Liquid dispensing device |
US9498778B2 (en) | 2014-11-11 | 2016-11-22 | Genmark Diagnostics, Inc. | Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system |
USD881409S1 (en) | 2013-10-24 | 2020-04-14 | Genmark Diagnostics, Inc. | Biochip cartridge |
US10191071B2 (en) | 2013-11-18 | 2019-01-29 | IntegenX, Inc. | Cartridges and instruments for sample analysis |
US10180133B2 (en) * | 2013-11-22 | 2019-01-15 | Rheonix, Inc. | Channel-less pump, methods, and applications thereof |
CN106660045B (zh) | 2014-02-05 | 2020-02-21 | 达丽斯生物医学公司 | 具有逐步加压机构的样品制备模块 |
EP2905079A1 (de) * | 2014-02-10 | 2015-08-12 | Robert Bosch Gmbh | Vorrichtung zum Vorlagern eines Fluids in einem mikrofluidischen System, Verfahren zum Betreiben und Verfahren zum Herstellen einer solchen Vorrichtung |
US10208332B2 (en) | 2014-05-21 | 2019-02-19 | Integenx Inc. | Fluidic cartridge with valve mechanism |
US10884008B2 (en) | 2014-06-05 | 2021-01-05 | Hitachi High-Tech Corporation | Device for storing biochemical reagents, and biochemical analyzer |
DE102014216391A1 (de) | 2014-08-19 | 2016-02-25 | Robert Bosch Gmbh | Reagenzienvorlagerung mit definierter Entnahme |
JP6502364B2 (ja) * | 2014-08-20 | 2019-04-17 | 株式会社シン・コーポレイション | 検査用装置 |
CN107106983B (zh) | 2014-10-22 | 2021-04-16 | 尹特根埃克斯有限公司 | 用于样品制备、处理和分析的系统和方法 |
US10005080B2 (en) | 2014-11-11 | 2018-06-26 | Genmark Diagnostics, Inc. | Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation |
US9598722B2 (en) | 2014-11-11 | 2017-03-21 | Genmark Diagnostics, Inc. | Cartridge for performing assays in a closed sample preparation and reaction system |
CN104399540B (zh) * | 2014-12-10 | 2016-04-27 | 天津微纳芯科技有限公司 | 一种基于离心作用的微流控芯片液体试剂释放方法 |
GB2535998A (en) * | 2015-02-27 | 2016-09-07 | Intelligent Fingerprinting Ltd | A device for receiving and analysing a sample |
WO2016175229A1 (ja) * | 2015-04-30 | 2016-11-03 | シスメックス株式会社 | 液体封止カートリッジ、検体分析装置、および、検体分析方法 |
JP6654874B2 (ja) * | 2015-11-26 | 2020-02-26 | 株式会社日立ハイテクノロジーズ | 保存容器、流動カートリッジ、および吐出機構 |
EP3383538B1 (en) | 2015-12-01 | 2022-03-09 | Illumina, Inc. | Liquid storage and delivery mechanisms |
DE102015226417A1 (de) | 2015-12-22 | 2017-06-22 | Robert Bosch Gmbh | Mikrofluidische Vorrichtung, Verfahren zum Herstellen und Verfahren zum Betreiben einer mikrofluidischen Vorrichtung |
EP3263215B1 (de) * | 2016-06-30 | 2021-04-28 | ThinXXS Microtechnology AG | Vorrichtung mit einer flusszelle mit reagenzspeicher |
GB201615452D0 (en) * | 2016-09-12 | 2016-10-26 | Fluidic Analytics Ltd | Improvements in or relating to valves for microfluidics devices |
JP2019536993A (ja) | 2016-10-07 | 2019-12-19 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハーBoehringer Ingelheim Vetmedica GmbH | サンプルを検査するためのカートリッジ、分析システム、及び方法 |
CN106434282B (zh) * | 2016-10-27 | 2018-12-07 | 杭州安誉科技有限公司 | 微型流体液泡挤压机构 |
JP6421159B2 (ja) * | 2016-10-28 | 2018-11-07 | シスメックス株式会社 | 液体封止カートリッジおよび送液方法 |
DE102017206489A1 (de) * | 2017-04-18 | 2018-10-18 | Robert Bosch Gmbh | Vorrichtung und Verfahren für ein mikrofluidisches System zum Analysieren einer Probe |
CN110621406B (zh) * | 2017-05-11 | 2022-02-22 | 芯易诊有限公司 | 试剂封装装置及其用途 |
EP3406340B1 (de) * | 2017-05-26 | 2021-07-07 | Thinxxs Microtechnology Ag | Flusszelle mit gehäusebauteil |
US11099202B2 (en) * | 2017-10-20 | 2021-08-24 | Tecan Genomics, Inc. | Reagent delivery system |
US10046322B1 (en) | 2018-03-22 | 2018-08-14 | Talis Biomedical Corporation | Reaction well for assay device |
WO2020053111A1 (en) * | 2018-09-11 | 2020-03-19 | F. Hoffmann-La Roche Ag | Cartridge with liquid pack |
CN109847820A (zh) * | 2019-04-18 | 2019-06-07 | 天津诺迈科技有限公司 | 微流控芯片预封装装置及使用方法 |
CN110252434B (zh) * | 2019-06-27 | 2022-08-09 | 深圳华迈兴微医疗科技有限公司 | 一种用于微流控芯片的液体储存结构及微流控芯片 |
WO2021038049A1 (en) * | 2019-08-29 | 2021-03-04 | Astraveus | Apparatus and method for clamping a microfluidic device |
CN112675933A (zh) * | 2019-10-18 | 2021-04-20 | 利多(香港)有限公司 | 一种用于检测分析物的微流控芯片 |
CN113101986B (zh) * | 2020-06-17 | 2022-09-16 | 京东方科技集团股份有限公司 | 一种用于试剂存储和释放的装置以及微流控装置 |
WO2022125077A1 (en) * | 2020-12-08 | 2022-06-16 | Hp Health Solutions Inc. | Sample preparation cartridge module |
WO2022131232A1 (ja) * | 2020-12-18 | 2022-06-23 | 京セラ株式会社 | 包装体、流路デバイスおよび測定装置 |
JP2024512806A (ja) * | 2021-04-01 | 2024-03-19 | オスラー ダイアグノスティクス リミテッド | 液体貯蔵キャビティ |
EP4129480A1 (en) * | 2021-08-06 | 2023-02-08 | Microliquid SL | Blister opening system comprising a blister and an actuation pusher |
CN114100711B (zh) * | 2021-11-17 | 2022-11-29 | 江苏液滴逻辑生物技术有限公司 | 一种芯片试剂的包装、预埋与注样装置及方法与用途 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3689224A (en) * | 1966-04-13 | 1972-09-05 | Westinghouse Electric Corp | Chemical contaminant detection sampler |
US5290518A (en) | 1992-08-17 | 1994-03-01 | Eastman Kodak Company | Flexible extraction device with burstable sidewall |
JP3558466B2 (ja) | 1995-10-06 | 2004-08-25 | 有限会社五味製作所 | ボビン装置 |
JPH09175538A (ja) * | 1995-12-22 | 1997-07-08 | Bussan Dairekuto Maaketeingu Kk | 液体・粘体等の使い捨て可能な収納容器 |
US6660527B2 (en) * | 2002-03-28 | 2003-12-09 | David Karl Stroup | Fluid-transfer collection assembly and method of using the same |
DE10336850B4 (de) | 2003-08-11 | 2006-10-26 | Thinxxs Gmbh | Mikrospeicher |
FR2872288B1 (fr) * | 2004-06-28 | 2007-08-03 | Biomerieux Sa | Dispositif d'analyse integre, adaptable sur un conteneur d'un echantillon a analyser |
JP2006308366A (ja) * | 2005-04-27 | 2006-11-09 | Hitachi High-Technologies Corp | 化学分析装置及び化学分析カートリッジ |
US7749453B2 (en) * | 2005-05-04 | 2010-07-06 | Bionostics, Inc. | Devices, systems, and methods for the containment and use of liquid solutions |
US20060264779A1 (en) | 2005-05-09 | 2006-11-23 | Kemp Timothy M | Fluidic medical devices and uses thereof |
WO2006132666A1 (en) | 2005-06-06 | 2006-12-14 | Decision Biomarkers, Inc. | Assays based on liquid flow over arrays |
RU2403198C2 (ru) | 2005-09-02 | 2010-11-10 | Мдс Глобал Холдинг Лтд. | Контейнер для выдачи вещества |
US8741230B2 (en) * | 2006-03-24 | 2014-06-03 | Theranos, Inc. | Systems and methods of sample processing and fluid control in a fluidic system |
DE102007059533A1 (de) * | 2007-12-06 | 2009-06-10 | Thinxxs Microtechnology Ag | Mikrofluidische Speichervorrichtung |
DE102011003856B4 (de) * | 2011-02-09 | 2020-06-18 | Robert Bosch Gmbh | Mikrosystem für fluidische Anwendungen sowie Herstellungsverfahren und Benutzungsverfahren für ein Mikrosystem für fluidische Anwendungen |
-
2009
- 2009-06-02 US US12/999,323 patent/US8795607B2/en active Active
- 2009-06-02 CN CN2009801292080A patent/CN102105227B/zh active Active
- 2009-06-02 EP EP09765532.8A patent/EP2300164B1/en active Active
- 2009-06-02 WO PCT/EP2009/003907 patent/WO2009152952A1/en active Application Filing
- 2009-06-02 JP JP2011513905A patent/JP5401542B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
EP2300164B1 (en) | 2018-03-14 |
WO2009152952A1 (en) | 2009-12-23 |
CN102105227A (zh) | 2011-06-22 |
US20110186466A1 (en) | 2011-08-04 |
CN102105227B (zh) | 2013-11-06 |
US8795607B2 (en) | 2014-08-05 |
EP2300164A1 (en) | 2011-03-30 |
JP2011524313A (ja) | 2011-09-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5401542B2 (ja) | 流体計量容器 | |
US11364500B2 (en) | Reagent reservoir for fluids | |
US9963273B2 (en) | Film bag for storing a fluid and device for providing a fluid | |
US9757724B2 (en) | Apparatus for hermetically sealed storage of liquids for a microfluidic system | |
US9005546B2 (en) | Flow cell having integrated fluid reservoir | |
US9937496B2 (en) | Methods of constructing a diagnostic cartridge and a fluid storage and delivery apparatus therefor | |
US9168524B2 (en) | Microfluidic storage device for pre-storing of fluid, method for its production and a use thereof | |
JP2014502236A (ja) | 液体用包装材並びにその使用及び液体をフルイディック組立体に供給する方法 | |
CN108472648B (zh) | 微流体设备,用于制造微流体设备的方法以及用于运行微流体设备的方法 | |
US20220314224A1 (en) | Reagent packaging devices and uses thereof | |
US20150336099A1 (en) | Micro-reagent handler and cartridge assembly | |
GB2538846A (en) | Storage unit, method for manufacturing a storage unit and method for releasing fluid stored in a storage unit | |
US20230372929A1 (en) | Integrated fluid module and test device |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120604 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20120604 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20130517 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20130529 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130828 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20131002 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20131028 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5401542 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |