JP3921233B2 - 流体チップ、それを用いた流体移動制御方法、および化学反応装置 - Google Patents
流体チップ、それを用いた流体移動制御方法、および化学反応装置 Download PDFInfo
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- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
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- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
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- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0034—Operating means specially adapted for microvalves
- F16K99/0042—Electric operating means therefor
- F16K99/0046—Electric operating means therefor using magnets
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00819—Materials of construction
- B01J2219/00833—Plastic
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00851—Additional features
- B01J2219/00858—Aspects relating to the size of the reactor
- B01J2219/0086—Dimensions of the flow channels
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00891—Feeding or evacuation
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00925—Irradiation
- B01J2219/0093—Electric or magnetic energy
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K2099/0082—Microvalves adapted for a particular use
- F16K2099/0084—Chemistry or biology, e.g. "lab-on-a-chip" technology
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/8593—Systems
- Y10T137/87265—Dividing into parallel flow paths with recombining
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
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- General Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mechanical Engineering (AREA)
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- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Fluid Mechanics (AREA)
- Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Magnetically Actuated Valves (AREA)
- Micromachines (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Description
10 導入口
12 流出口
13 集合部
M 磁性流体
21 磁性粒子
22,39,40,41,54,102,103,104,105 流路
23 磁石
24 液体
25,34 液体支持体
35,36,37,112,113,114,115 チャンバー
110 中央チャンバー
51,52 電磁石
103a,104a,105a 分岐
110 中央チャンバー
125 色素溶液
Claims (26)
- 液体を支持する液体支持体と、
前記液体支持体に囲まれてなり前記液体が移動する流路と、
前記流路内に配置された複数の磁性粒子と
を備え、
前記磁性粒子に第1の磁力を作用させて前記磁性粒子を凝集させることで前記流路を閉塞し、前記液体の流れを遮断する閉状態と、
前記第1の磁力より弱い第2の磁力を作用させて前記磁性粒子を前記流路の壁面の一部に分散させることで前記流路を開放し、前記液体を流す開状態と
の間で可逆的に切り換え可能である流体チップ。 - 前記磁性粒子の径が、1μm以上100μm以下であることを特徴とする、請求項1に記載の流体チップ。
- 前記液体は親水性の液体であり、かつ前記磁性粒子の表面が撥水性を有することを特徴とする、請求項1に記載の流体チップ。
- 前記磁性粒子の表面の撥水性が、撥水ポリマーによる処理で付与されていることを特徴とする、請求項1に記載の流体チップ。
- 前記磁性粒子の表面の撥水性が、疎水性官能基を表面に修飾する処理で付与されていることを特徴とする、請求項4に記載の流体チップ。
- 前記液体は疎水性の液体であり、かつ前記磁性粒子の表面が親水性を有することを特徴とする、請求項1に記載の流体チップ。
- 前記磁性粒子の表面の親水性が、親水ポリマーによる処理で付与されていることを特徴とする、請求項6に記載の流体チップ。
- 前記流路の断面積が1μm2以上1×106μm2以下である、請求項1に記載の流体チップ。
- 流体チップ内の液体の移動を制御する方法であって、
前記流体チップは、前記液体を支持する液体支持体と、前記液体支持体に囲まれてなり前記液体が移動する流路と、前記流路内に配置された複数の磁性粒子とを備え、
前記方法は、
磁石から前記複数の磁性粒子に第1の磁力を作用させ、それによって前記複数の磁性粒子を凝集させて前記流路を閉塞し、前記液体の流れを遮断する工程、および
前記磁石から前記複数の磁性粒子に前記第1の磁力よりも弱い第2の磁力を作用させ、それによって前記流路の壁面の一部に前記複数の磁性粒子を分散させて前記流路を開放し、前記液体の流れを許可する工程、を有し、
前記第1の磁力を作用させることによる前記複数の磁性粒子の凝集と、前記第2の磁力を作用させることによる前記複数の磁性粒子の分散とを可逆的に切り換え可能である方法。 - 前記複数の磁性粒子に前記第1の磁力が作用する状態を維持しつつ前記磁石を移動させ、前記複数の磁性粒子を前記凝集した状態を維持しつつ前記流路の一つの位置から他の位置へ移動させ、それによって前記流路内の液体を移動させることを特徴とする、請求項9に記載の方法。
- 前記複数の磁性粒子に前記第2の磁力を作用する状態を維持しつつ前記磁石を移動させ、前記複数の磁性粒子を前記流路の壁面に分散した状態を維持しつつ前記流路内の一つの位置から他の位置へ移動させることを特徴とする、請求項9に記載の方法。
- 前記磁性粒子の径が、1μm以上100μm以下であることを特徴とする、請求項9に記載の方法。
- 前記磁石は永久磁石であることを特徴とする、請求項9に記載の方法。
- 前記磁石は電磁石であることを特徴とする、請求項9に記載の方法。
- 前記液体として親水性の液体を用い、かつ前記磁性粒子の表面が撥水性を有することを特徴とする、請求項9に記載の方法。
- 前記磁性粒子の表面の撥水性が、撥水ポリマーによる処理で付与されていることを特徴とする、請求項15に記載の方法。
- 前記磁性粒子の表面の撥水性が、疎水性官能基を表面に修飾する処理で付与されていることを特徴とする、請求項15に記載の方法。
- 前記液体として疎水性の液体を用い、かつ前記磁性粒子の表面が親水性を有することを特徴とする、請求項9に記載の方法。
- 前記磁性粒子の表面の親水性が、親水ポリマーによる処理で付与されていることを特徴とする、請求項18に記載の方法。
- 前記流路の断面積が1μm2以上1×106μm2以下である、請求項9に記載の方法。
- 流路と、チャンバーと、前記流路内に配置された複数の磁性粒子とを有し、外部から前記流路および前記チャンバーに液体を導入して、化学反応を前記チャンバーまたは前記流路にて行うための流体チップと、
前記複数の磁性粒子に第1の磁力を及ぼして前記複数の磁性粒子を凝集させて前記流路を閉塞し、それによって前記液体の流れを遮断する閉状態と、前記複数の磁性粒子に前記第1の磁力よりも弱い第2の磁力を及ぼして前記複数の磁性粒子を前記流路の壁面の一部に分散させて前記流路を開放し、それによって前記液体を流す開状態とを可逆的に切り換えるように、前記流体チップに生じる磁界を制御可能な磁界発生装置と
を備える、化学反応装置。 - 前記磁界発生装置による前記磁界の制御により、前記磁性粒子を前記流路の分岐点又は前記流路に凝集させて閉状態とすることにより流路を切り替え、前記液体を目的の前記流路もしくは前記チャンバーに移動させることを特徴とする、請求項21に記載の化学反応装置。
- 前記磁界発生装置は、前記第1の磁力によって前記凝集した状態を維持しつつ前記複数の磁性粒子が前記流路の一つの位置から他の位置へ移動するように、前記磁界を制御可能であることを特徴とする、請求項21に記載の化学反応装置。
- 前記磁界発生装置は、前記第2の磁力によって前記流路の壁面に分散した状態を維持しつつ前記複数の磁性粒子を前記流路内の一つの位置から他の位置へ移動するように、前記磁界を制御可能であることを特徴とする、請求項21に記載の化学反応装置。
- 前記磁界発生装置が永久磁石を備えることを特徴とする、請求項21に記載の化学反応装置。
- 前記磁界発生装置が電磁石を備えることを特徴とする、請求項21に記載の化学反応装置。
Applications Claiming Priority (3)
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JP2005034591 | 2005-02-10 | ||
JP2005034591 | 2005-02-10 | ||
PCT/JP2006/301324 WO2006085443A1 (ja) | 2005-02-10 | 2006-01-27 | 流体チップ、それを用いた流体移動制御方法、および化学反応装置 |
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JP3921233B2 true JP3921233B2 (ja) | 2007-05-30 |
JPWO2006085443A1 JPWO2006085443A1 (ja) | 2010-01-21 |
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US (1) | US7547415B2 (ja) |
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WO (1) | WO2006085443A1 (ja) |
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