JPWO2006085443A1 - 流体チップ、それを用いた流体移動制御方法、および化学反応装置 - Google Patents
流体チップ、それを用いた流体移動制御方法、および化学反応装置 Download PDFInfo
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Abstract
Description
10 導入口
12 流出口
13 集合部
M 磁性流体
21 磁性粒子
22,39,40,41,54,102,103,104,105 流路
23 磁石
24 液体
25,34 液体支持体
35,36,37,112,113,114,115 チャンバー
110 中央チャンバー
51,52 電磁石
103a,104a,105a 分岐
110 中央チャンバー
125 色素溶液
10 導入口
12 流出口
13 集合部
M 磁性流体
21 磁性粒子
22,39,40,41,54,102,103,104,105 流路
23 磁石
24 液体
25,34 液体支持体
35,36,37,112,113,114,115 チャンバー
110 中央チャンバー
51,52 電磁石
103a,104a,105a 分岐
110 中央チャンバー
125 色素溶液
Claims (26)
- 液体を支持する液体支持体と、
前記液体支持体に囲まれてなり前記液体が移動する流路と、
前記流路内に配置された複数の磁性粒子と
を備え、
前記磁性粒子に第1の磁力を作用させて前記磁性粒子を凝集させることで前記流路を閉塞し、前記液体の流れを遮断する閉状態と、
前記第1の磁力より弱い第2の磁力を作用させて前記磁性粒子を前記流路の壁面の一部に分散させることで前記流路を開放し、前記液体を流す開状態と
の間で可逆的に切り換え可能である流体チップ。 - 前記磁性粒子の径が、1μm以上100μm以下であることを特徴とする、請求項1に記載の流体チップ。
- 前記液体は親水性の液体であり、かつ前記磁性粒子の表面が撥水性を有することを特徴とする、請求項1に記載の流体チップ。
- 前記磁性粒子の表面の撥水性が、撥水ポリマーによる処理で付与されていることを特徴とする、請求項1に記載の流体チップ。
- 前記磁性粒子の表面の撥水性が、疎水性官能基を表面に修飾する処理で付与されていることを特徴とする、請求項4に記載の流体チップ。
- 前記液体は疎水性の液体であり、かつ前記磁性粒子の表面が親水性を有することを特徴とする、請求項1に記載の流体チップ。
- 前記磁性粒子の表面の親水性が、親水ポリマーによる処理で付与されていることを特徴とする、請求項6に記載の流体チップ。
- 前記流路の断面積が1μm2以上1×106μm2以下である、請求項1に記載の流体チップ。
- 流体チップ内の液体の移動を制御する方法であって、
前記流体チップは、前記液体を支持する液体支持体と、前記液体支持体に囲まれてなり前記液体が移動する流路と、前記流路内に配置された複数の磁性粒子とを備え、
前記方法は、
磁石から前記複数の磁性粒子に第1の磁力を作用させ、それによって前記複数の磁性粒子を凝集させて前記流路を閉塞し、前記液体の流れを遮断する工程、および
前記磁石から前記複数の磁性粒子に前記第1の磁力よりも弱い第2の磁力を作用させ、それによって前記流路の壁面の一部に前記複数の磁性粒子を分散させて前記流路を開放し、前記液体の流れを許可する工程、を有し、
前記第1の磁力を作用させることによる前記複数の磁性粒子の凝集と、前記第2の磁力を作用させることによる前記複数の磁性粒子の分散とを可逆的に切り換え可能である方法。 - 前記複数の磁性粒子に前記第1の磁力が作用する状態を維持しつつ前記磁石を移動させ、前記複数の磁性粒子を前記凝集した状態を維持しつつ前記流路の一つの位置から他の位置へ移動させ、それによって前記流路内の液体を移動させることを特徴とする、請求項8に記載の方法。
- 前記複数の磁性粒子に前記第2の磁力を作用する状態を維持しつつ前記磁石を移動させ、前記複数の磁性粒子を前記流路の壁面に分散した状態を維持しつつ前記流路内の一つの位置から他の位置へ移動させることを特徴とする、請求項9に記載の方法。
- 前記磁性粒子の径が、1μm以上100μm以下であることを特徴とする、請求項9に記載の方法。
- 前記磁石は永久磁石であることを特徴とする、請求項9に記載の方法。
- 前記磁石は電磁石であることを特徴とする、請求項9に記載の方法。
- 前記液体として親水性の液体を用い、かつ前記磁性粒子の表面が撥水性を有することを特徴とする、請求項9に記載の方法。
- 前記磁性粒子の表面の撥水性が、撥水ポリマーによる処理で付与されていることを特徴とする、請求項15に記載の方法。
- 前記磁性粒子の表面の撥水性が、疎水性官能基を表面に修飾する処理で付与されていることを特徴とする、請求項15に記載の方法。
- 前記液体として疎水性の液体を用い、かつ前記磁性粒子の表面が親水性を有することを特徴とする、請求項9に記載の方法。
- 前記磁性粒子の表面の親水性が、親水ポリマーによる処理で付与されていることを特徴とする、請求項18に記載の方法。
- 前記流路の断面積が1μm2以上1×106μm2以下である、請求項9に記載の方法。
- 流路と、チャンバーと、前記流路内に配置された複数の磁性粒子とを有し、外部から前記流路および前記チャンバーに液体を導入して、化学反応を前記チャンバーまたは前記流路にて行うための流体チップと、
前記複数の磁性粒子に第1の磁力を及ぼして前記複数の磁性粒子を凝集させて前記流路を閉塞し、それによって前記液体の流れを遮断する閉状態と、前記複数の磁性粒子に前記第1の磁力よりも弱い第2の磁力を及ぼして前記複数の磁性粒子を前記流路の壁面の一部に分散させて前記流路を開放し、それによって前記液体を流す開状態とを可逆的に切り換えるように、前記流体チップに生じる磁界を制御可能な磁界発生装置と
を備える、化学反応装置。 - 前記磁界発生装置による前記磁界の制御により、前記磁性粒子を前記流路の分岐点又は前記流路に凝集させて閉状態とすることにより流路を切り替え、前記液体を目的の前記流路もしくは前記チャンバーに移動させることを特徴とする、請求項21に記載の化学反応装置。
- 前記磁界発生装置は、前記第1の磁力によって前記凝集した状態を維持しつつ前記複数の磁性粒子が前記流路の一つの位置から他の位置へ移動するように、前記磁界を制御可能であることを特徴とする、請求項21に記載の化学反応装置。
- 前記磁界発生装置は、前記第2の磁力によって前記流路の壁面に分散した状態を維持しつつ前記複数の磁性粒子を前記流路内の一つの位置から他の位置へ移動するように、前記磁界を制御可能であることを特徴とする、請求項21に記載の化学反応装置。
- 前記磁界発生装置が永久磁石を備えることを特徴とする、請求項21に記載の化学反応装置。
- 前記磁界発生装置が電磁石を備えることを特徴とする、請求項21に記載の化学反応装置。
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PCT/JP2006/301324 WO2006085443A1 (ja) | 2005-02-10 | 2006-01-27 | 流体チップ、それを用いた流体移動制御方法、および化学反応装置 |
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ATE542136T1 (de) * | 2010-03-15 | 2012-02-15 | Boehringer Ingelheim Int | Vorrichtung und verfahren zur manipulation oder untersuchung einer flüssigen probe |
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US8763642B2 (en) | 2010-08-20 | 2014-07-01 | Integenx Inc. | Microfluidic devices with mechanically-sealed diaphragm valves |
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CN113092563B (zh) | 2014-10-22 | 2024-06-07 | 尹特根埃克斯有限公司 | 用于样品制备、处理和分析的系统和方法 |
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US20020123134A1 (en) * | 2000-12-26 | 2002-09-05 | Mingxian Huang | Active and biocompatible platforms prepared by polymerization of surface coating films |
JP2003014772A (ja) | 2001-06-27 | 2003-01-15 | Tosoh Corp | 液体の輸送方法及びマイクロリアクター |
JP2003158883A (ja) * | 2001-11-16 | 2003-05-30 | Makoto Morishita | 機能性要素および該機能性要素を用いた流量可変バルブ |
JP2004073995A (ja) * | 2002-08-15 | 2004-03-11 | Kawamura Inst Of Chem Res | 流量制御方法、マイクロ流体デバイス、および流量制御装置 |
JP2004077258A (ja) * | 2002-08-15 | 2004-03-11 | Kawamura Inst Of Chem Res | 流路切替方法および流路切替装置 |
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US7547415B2 (en) | 2009-06-16 |
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