RU2018102079A - Бактерия для применения в качестве пробиотика, употребляемого с пищей и в медицине - Google Patents
Бактерия для применения в качестве пробиотика, употребляемого с пищей и в медицине Download PDFInfo
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- 235000013305 food Nutrition 0.000 title claims 5
- 239000006041 probiotic Substances 0.000 title claims 5
- 230000000529 probiotic effect Effects 0.000 title claims 5
- 235000018291 probiotics Nutrition 0.000 title claims 5
- 241000894006 Bacteria Species 0.000 title claims 2
- 230000001580 bacterial effect Effects 0.000 claims 19
- 235000015872 dietary supplement Nutrition 0.000 claims 11
- 108090000623 proteins and genes Proteins 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 108020004465 16S ribosomal RNA Proteins 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 206010012735 Diarrhoea Diseases 0.000 claims 4
- 230000033228 biological regulation Effects 0.000 claims 4
- 239000003085 diluting agent Substances 0.000 claims 4
- 239000000463 material Substances 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- -1 Vnn1 Proteins 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 210000000987 immune system Anatomy 0.000 claims 3
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- 235000013373 food additive Nutrition 0.000 claims 2
- 239000002778 food additive Substances 0.000 claims 2
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 102000052553 3-Hydroxyacyl CoA Dehydrogenase Human genes 0.000 claims 1
- 108700020831 3-Hydroxyacyl-CoA Dehydrogenase Proteins 0.000 claims 1
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- 102000005345 Acetyl-CoA C-acetyltransferase Human genes 0.000 claims 1
- 108010006229 Acetyl-CoA C-acetyltransferase Proteins 0.000 claims 1
- 208000012657 Atopic disease Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 108010068197 Butyryl-CoA Dehydrogenase Proteins 0.000 claims 1
- 101150113144 CARTPT gene Proteins 0.000 claims 1
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 206010010774 Constipation Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 101150074715 MAGI3 gene Proteins 0.000 claims 1
- 101150002477 MPP7 gene Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 101100331384 Mus musculus Defa20 gene Proteins 0.000 claims 1
- 101100063266 Mus musculus Defb37 gene Proteins 0.000 claims 1
- 101100063280 Mus musculus Defb50 gene Proteins 0.000 claims 1
- 101100180320 Mus musculus Itln1 gene Proteins 0.000 claims 1
- 101100289857 Mus musculus Ly6g6e gene Proteins 0.000 claims 1
- 101100400381 Mus musculus Marveld3 gene Proteins 0.000 claims 1
- 101100481584 Mus musculus Tlr1 gene Proteins 0.000 claims 1
- 206010051606 Necrotising colitis Diseases 0.000 claims 1
- 101100180325 Oncorhynchus mykiss itln gene Proteins 0.000 claims 1
- 101150038744 PMP22 gene Proteins 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 101150010925 Pxmp2 gene Proteins 0.000 claims 1
- 102100024639 Short-chain specific acyl-CoA dehydrogenase, mitochondrial Human genes 0.000 claims 1
- 101150096104 Sprr1a gene Proteins 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 230000033289 adaptive immune response Effects 0.000 claims 1
- 210000005006 adaptive immune system Anatomy 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
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- 230000035605 chemotaxis Effects 0.000 claims 1
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- 230000009429 distress Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 201000006549 dyspepsia Diseases 0.000 claims 1
- 201000000117 functional diarrhea Diseases 0.000 claims 1
- 244000005709 gut microbiome Species 0.000 claims 1
- 230000013632 homeostatic process Effects 0.000 claims 1
- 210000003405 ileum Anatomy 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 210000005007 innate immune system Anatomy 0.000 claims 1
- 208000028774 intestinal disease Diseases 0.000 claims 1
- 230000007246 mechanism Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 208000004995 necrotizing enterocolitis Diseases 0.000 claims 1
- 201000006195 perinatal necrotizing enterocolitis Diseases 0.000 claims 1
- 230000000291 postprandial effect Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 210000003289 regulatory T cell Anatomy 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 206010039083 rhinitis Diseases 0.000 claims 1
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- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
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Claims (26)
1. Штамм бактерий, характеризующийся ДНК-ДНК гомологией, составляющей по меньшей мере 70% со штаммом, депонированным под идентификационным номером NCIMB 14029, или, характеризующийся идентичностью по 16S рРНК, составляющей по меньшей мере 99,5% со штаммом, депонированным под идентификационным номером NCIMB 14029, для применения в медицине.
2. Фармацевтическая композиция, включающая штамм бактерий, характеризующийся ДНК-ДНК гомологией, составляющей по меньшей мере 70% со штаммом, депонированным под идентификационным номером NCIMB 14029, или, характеризующийся идентичностью по 16S рРНК, составляющей по меньшей мере 99,5% со штаммом, депонированным под идентификационным номером NCIMB 14029, и фармацевтически приемлемый наполнитель, носитель или разбавитель.
3. Пищевая добавка, включающая штамм бактерий, характеризующийся ДНК-ДНК гомологией, составляющей по меньшей мере 70% со штаммом, депонированным под идентификационным номером NCIMB 14029, или, характеризующийся идентичностью по 16S рРНК, составляющей по меньшей мере 99,5% со штаммом, депонированным под идентификационным номером NCIMB 14029, и алиментарно приемлемый наполнитель, носитель или разбавитель.
4. Пробиотическая композиция, кормовой материал, продукт питания, добавка к рациону или добавка к пищевому продукту, которые включают штамм бактерий, характеризующийся ДНК-ДНК гомологией, составляющей по меньшей мере 70% со штаммом, депонированным под идентификационным номером NCIMB 14029, или, характеризующийся идентичностью по 16S рРНК, составляющей по меньшей мере 99,5% со штаммом, депонированным под идентификационным номером NCIMB 14029.
5. Штамм бактерий для применения по п.1, фармацевтическая композиция по п.2, пищевая добавка по п.3 или пробиотическая композиция, кормовой материал, продукт питания, добавка к рациону или добавка к пищевому продукту по п.4, где:
штамм бактерий характеризуется ДНК-ДНК гомологией, составляющей по меньшей мере 75%, 80%, 85%, 90%, 95%, 97%, 98 или 99% со штаммом, депонированным под идентификационным номером NCIMB 14029; или
штамм бактерий характеризуется ДНК-ДНК гомологией, составляющей по меньшей мере 75%, 80%, 85%, 90%, 95%, 97%, 98 или 99% со штаммом, депонированным под идентификационным номером NCIMB 14029, и характеризуется идентичностью по 16S рРНК, составляющей по меньшей мере 99,5% со штаммом, депонированным под идентификационным номером NCIMB 14029; или
штаммом бактерий является штамм, депонированный под идентификационным номером NCIMB 14029.
6. Штамм бактерий для применения по п.1, фармацевтическая композиция по п.2, пищевая добавка по п.3 или пробиотическая композиция, кормовой материал, продукт питания, добавка к рациону или добавка к пищевому продукту по п.4, где штамм бактерий характеризуется геномом, который состоит из одной хромосомой размером 3592125 п.о. с четырьмя рибосомными оперонами, 66 РНК и 3273 предсказанными белками.
7. Штамм бактерий для применения по п.1, фармацевтическая композиция по п.2, пищевая добавка по п.3 или пробиотическая композиция, кормовой материал, продукт питания, добавка к рациону или добавка к пищевому продукту по п.4, где штамм бактерий представлен в форме лиофилизированной популяции бактерий.
8. Штамм бактерий для применения по п.1 или 5, где штамм предназначен для регуляции иммунной системы субъекта.
9. Штамм бактерий для применения по п.8, где регуляцией иммунной системы является регуляция адаптивной иммунной системы субъекта или регуляция врожденной иммунной системы субъекта.
10. Штамм бактерий для применения по п.1 или 5, где штамм предназначен для лечения нарушения, выбранного из воспалительного расстройства, иммунного нарушения и кишечного расстройства, такого как нарушения, выбранного из: синдрома разраженного кишечника (IBS), колита, воспалительного расстройства кишечника (IBD), в том числе болезни Крона и неспецифического язвенного колита, воспаления созданного хирургическим путем тонкокишечного резервуара, функциональной диспепсии, функционального запора, функциональной диареи, в том числе диареи, связанной с приемом антибиотиков, диареи путешественников и диареи у детей, функциональной боли в животе, функционального вздутия, болевого синдрома в эпигастральной области, постпрандиального дистресс-синдрома, гастроэзофагеальной рефлюксной болезни (GERD), аутоиммунных заболеваний, таких как сахарный диабет, артрит, рассеянный склероз и псориаз, аллергий, атопических заболеваний, в том числе атопического дерматита, некротизирующего энтероколита, других инфекционных заболеваний, глютеновой болезни и ринита, и их комбинаций.
11. Штамм бактерий для применения по п.1 или 5, где штамм предназначен для улучшения микробиоты кишечника у субъекта, предназначен для способствования здоровому состоянию пищеварительного тракта у субъекта, предназначен для применения для стимуляции регуляторных T-клеток и механизмов толерантности в иммунной системе, или предназначен для поддержания иммунного гомеостаза у субъекта.
12. Штамм бактерий для применения по любому из пп. 1 или 5-11, где штамм:
регулирует индукцию и/или экспрессию по меньшей мере одного гена, имеющего отношение к мобилизации или хемотаксису, более предпочтительно, увеличивает экспрессию гена, выбранного из MobA и MobL; или
регулирует по меньшей мере один ген, выбранный из FlaA1, FlaA2, Fla3 и FlaB; или
регулирует экспрессию по меньшей мере одного из следующего: ацетил-КоA-ацетилтрансферазы, 3-гидроксиацил-КоА-дегидрогеназы, бутирил-КоА-дегидрогеназы, бета-субъединицы окислительно-восстановительного флавопротеина, альфа-субъединицы окислительно-восстановительного флавопротеина; или
уменьшает экспрессию по меньшей мере одного гена, выбранного из Agt, Cartpt, Cck, Cxcl12 и Gcg; или
активирует по меньшей мере один ген, имеющий отношение к иммунному ответу, в ободочной или подвздошной кишке; или
активирует адаптивный иммунный ответ посредством регуляции индукции и/или экспрессии генов, связанных с регуляцией Т-клеток; или
увеличивает экспрессию по меньшей мере одного гена, выбранного из Ly6g6c и Ly6g6e, в восходящей части ободочной кишки; или
регулирует экспрессию по меньшей мере одного гена, выбранного из Tlr5, Tlr1, Vnn1, Defb37, Pla2g, Muc16, Itln, Sprr1a, Cldn4, Pmp22, Crb3, Magi3, Marveld3, Mpp7, Defcr20, Pcgf2, Ltbp4, Igsf8 и Tcfe2a.
13. Штамм бактерий для применения по любому из п.п. 1 или 5-11, где субъектом является млекопитающее, предпочтительно человек.
14. Фармацевтическая композиция по п.2, отличающаяся тем, что композиция адаптирована для перорального внесения.
15. Способ получения фармацевтической композиции по п.2 или пищевой добавки по п.3, включающий смешивание штамма бактерий с фармацевтически приемлемым наполнителем, носителем или разбавителем, или с алиментарно приемлемым наполнителем, носителем или разбавителем.
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