HRP20160843T1 - Bakterija za upotrebu kao probiotik za nutritivne i medicinske primjene - Google Patents
Bakterija za upotrebu kao probiotik za nutritivne i medicinske primjene Download PDFInfo
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- HRP20160843T1 HRP20160843T1 HRP20160843TT HRP20160843T HRP20160843T1 HR P20160843 T1 HRP20160843 T1 HR P20160843T1 HR P20160843T T HRP20160843T T HR P20160843TT HR P20160843 T HRP20160843 T HR P20160843T HR P20160843 T1 HRP20160843 T1 HR P20160843T1
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- bacterial species
- use according
- roseburia hominis
- subject
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- 241000894006 Bacteria Species 0.000 title claims 3
- 239000006041 probiotic Substances 0.000 title claims 2
- 230000000529 probiotic effect Effects 0.000 title claims 2
- 235000018291 probiotics Nutrition 0.000 title claims 2
- 235000016709 nutrition Nutrition 0.000 title 1
- 230000001580 bacterial effect Effects 0.000 claims 26
- 241000894007 species Species 0.000 claims 16
- 241000872832 Roseburia hominis Species 0.000 claims 14
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 230000033228 biological regulation Effects 0.000 claims 5
- 206010012735 Diarrhoea Diseases 0.000 claims 4
- 235000015872 dietary supplement Nutrition 0.000 claims 4
- 239000003085 diluting agent Substances 0.000 claims 4
- 210000000987 immune system Anatomy 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- -1 Vnn1 Proteins 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000026278 immune system disease Diseases 0.000 claims 3
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 206010012438 Dermatitis atopic Diseases 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- 201000008937 atopic dermatitis Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 102000052553 3-Hydroxyacyl CoA Dehydrogenase Human genes 0.000 claims 1
- 108700020831 3-Hydroxyacyl-CoA Dehydrogenase Proteins 0.000 claims 1
- 208000004998 Abdominal Pain Diseases 0.000 claims 1
- 206010000087 Abdominal pain upper Diseases 0.000 claims 1
- 102000005345 Acetyl-CoA C-acetyltransferase Human genes 0.000 claims 1
- 108010006229 Acetyl-CoA C-acetyltransferase Proteins 0.000 claims 1
- 208000012657 Atopic disease Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 108010068197 Butyryl-CoA Dehydrogenase Proteins 0.000 claims 1
- 101150113144 CARTPT gene Proteins 0.000 claims 1
- 101100420681 Caenorhabditis elegans tir-1 gene Proteins 0.000 claims 1
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 206010010774 Constipation Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 101150074715 MAGI3 gene Proteins 0.000 claims 1
- 101150002477 MPP7 gene Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 101100331384 Mus musculus Defa20 gene Proteins 0.000 claims 1
- 101100063266 Mus musculus Defb37 gene Proteins 0.000 claims 1
- 101100063280 Mus musculus Defb50 gene Proteins 0.000 claims 1
- 101100289857 Mus musculus Ly6g6e gene Proteins 0.000 claims 1
- 101100400381 Mus musculus Marveld3 gene Proteins 0.000 claims 1
- 206010051606 Necrotising colitis Diseases 0.000 claims 1
- 101150038744 PMP22 gene Proteins 0.000 claims 1
- 101150010925 Pxmp2 gene Proteins 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 102100024639 Short-chain specific acyl-CoA dehydrogenase, mitochondrial Human genes 0.000 claims 1
- 101150096104 Sprr1a gene Proteins 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 101150078250 Tcf3 gene Proteins 0.000 claims 1
- 230000033289 adaptive immune response Effects 0.000 claims 1
- 210000005006 adaptive immune system Anatomy 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 206010003074 arachnoiditis Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 230000001174 ascending effect Effects 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 230000035605 chemotaxis Effects 0.000 claims 1
- 206010009887 colitis Diseases 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 230000009429 distress Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 201000006549 dyspepsia Diseases 0.000 claims 1
- 206010016766 flatulence Diseases 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 201000000117 functional diarrhea Diseases 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 244000005709 gut microbiome Species 0.000 claims 1
- 230000013632 homeostatic process Effects 0.000 claims 1
- 210000003405 ileum Anatomy 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 210000005007 innate immune system Anatomy 0.000 claims 1
- 208000028774 intestinal disease Diseases 0.000 claims 1
- 230000007246 mechanism Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 208000004995 necrotizing enterocolitis Diseases 0.000 claims 1
- 235000020939 nutritional additive Nutrition 0.000 claims 1
- 201000006195 perinatal necrotizing enterocolitis Diseases 0.000 claims 1
- 230000000291 postprandial effect Effects 0.000 claims 1
- 238000010992 reflux Methods 0.000 claims 1
- 210000003289 regulatory T cell Anatomy 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
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- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/10—Laxatives
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P17/06—Antipsoriatics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Claims (20)
1. Bakterijska vrsta Roseburia hominis za upotrebu u medicini.
2. Farmaceutski sastav koji sadrži bakterijsku vrstu Roseburia hominis i farmaceutski prihvatljiv ekscipijens, nosač ili diluent.
3. Nutritivni dodatak koji sadrži bakterijsku vrstu Roseburia hominis i nutritivno prihvatljiv ekscipijens, nosač ili diluent.
4. Probiotski sastav koji sadrži bakterijsku vrstu Roseburia hominis.
5. Hrana za životinje, prehrambeni proizvod, dijetetski suplement, nutritivni dodatak ili aditiv koji sadrži bakterijsku vrstu Roseburia hominis.
6. Bakterijska vrsta Roseburia hominis za upotrebu prema zahtjevu 1 naznačena time što je bakterijska vrsta za upotrebu u reguliranju imunog sustava subjekta.
7. Bakterijska vrsta za upotrebu prema zahtjevu 6, naznačena time što regulacija imunog sustava je regulacija adaptivnog imunog sustava subjekta.
8. Bakterijska vrsta za upotrebu prema zahtjevu 6, naznačena time što regulacija imunog sustava podrazumijeva regulaciju urođenog imunog sustava subjekta.
9. Bakterijska vrsta Roseburia hominis za upotrebu prema zahtjevu 1 naznačena time što je bakterijska vrsta za upotrebu u održavanju imune homeostaze kod subjekta.
10. Bakterijska vrsta Roseburia hominis za upotrebu prema zahtjevu 1 naznačena time što je bakterijska vrsta za upotrebu u liječenju imunog poremećaja kod subjekta.
11. Bakterijska vrsta za upotrebu prema zahtjevu 10, naznačena time što je imuni poremećaj odabran od slijedećeg: ulcerativni kolitis, paučitis, drugih autoimunih stanja uključujući reumatoidni artritis, psorijazu, multiplu sklerozu, alergije, uključujući celijakiju, atopični dermatitis i rinitis.
12. Bakterijska vrsta Roseburia hominis za upotrebu prema zahtjevu 1 naznačena time što je bakterija za upotrebu u liječenju poremećaja odabranog od upalnog poremećaja, imunog poremećaja i crijevnog poremećaja kod subjekta.
13. Bakterijska vrsta za upotrebu prema zahtjevu 12, naznačena time što je poremećaj odabran od sindroma iritabilnog crijeva (IBS), kolitisa, upalne bolesti crijeva (IBD), uključujući Kronovu bolest i ulcerozni kolitis, paučitis, funkcionalnu dispepsiju, funkcionalnu konstipaciju, funkcionalnu dijareju (uključujući sa antibioticima povezanu dijareju, putničku dijareju i pedijatrijsku dijareju), funkcionalni abdominalni bol, funkcionalnu nadutost, sindrom epigastričnog bola, postprandijalni distres sindrom, gastrointestinalnu refluksnu bolest (GERD), autoimune bolesti kao što su dijabetes, artritis, multipla skleroza i psorijaza, atopične bolesti npr. atopijski dermatitis, nekrotizirajući enterokolitis, druge infekcije, i njihove kombinacije.
14. Bakterijska vrsta Roseburia hominis za upotrebu prema zahtjevu 1 naznačena time što je bakterija za upotrebu u popravljanju crijevne mikroflore kod subjekta.
15. Bakterijska vrsta Roseburia hominis za upotrebu prema zahtjevu 1 naznačena time što je bakterijska vrsta za upotrebu u unaprijeđenju zdravlja crijeva subjekta.
16. Bakterijska vrsta Roseburia hominis za upotrebu prema zahtjevu 1 naznačena time što je bakterijska vrsta za upotrebu u unaprijeđenju Tregs ćelija i mehanizama tolerancije imunog sustava subjekta.
17. Bakterijska vrsta za upotrebu prema bilo kojem od patentnih zahtjeva 1 do 16, pri čemu bakterijska vrsta:
(i) regulira indukciju i/ili ekspresiju najmanje jednog gena za mobilizaciju ili kemotaksu, poželjnije pozitivno regulira ekspresiju gena izabranog od MobA i MobL; ili
(ii) regulira najmanje jedan gen odabran od FlaA1, Fla2, FlaA3, i FlaB; ili
(iii) regulira ekspresiju najmanje jednog od slijedećeg: acetil-CoA acetiltransferaza, 3-hidroksiacil-CoA dehidrogenaza, butiril-CoA dehidrogenaza, beta podjedinice elektron-prijenosnog-flavoproteina, alfa podjedinice elektron-prijenosnog-flavoproteina; ili
(iv) negativno regulira ekspresiju najmanje jednog gena izabranog od Agt, Cartpt, Cck, Cxcl12 i Gcg; ili
(v) aktivira najmanje jedan gen za imunski odgovor u kolonu ili ileumu; ili
(vi) aktivira adaptivni imuni odgovor i regulira indukciju i/ili ekspresiju gena povezanih sa regulacijom T-ćelija; ili
(vii) pozitivno regulira ekspresiju najmanje jednog gena izabranog od Ly6g6c i Ly6g6e u uzlaznom kolonu; ili
(viii) regulira ekspresiju najmanje jednog gena koji je izabran od Tlr5, TiR1, Vnn1, Defb37, Pla2g, Muc16, ltln, Sprr1a, Cldn4, Pmp22, Crb3, Magi3, Marveld3, Mpp7, Defcr20, Pcgf2, Ltbp4, Igsf8 i Tcfe2a.
18. Bakterijska vrsta za upotrebu prema bilo kojem od zahtjeva 1 do 17 gdje je subjekt sisavac, poželjno čovek.
19. Postupak za proizvodnju farmaceutskog sastava prema zahtjevu 2, naznačen time što sadrži miješanje bakterijske vrste Roseburia hominis sa farmaceutski prihvatljivim ekscipijensom, nosačem ili diluentom.
20. Postupak za proizvodnju nutritivnog dodatka prema zahtjevu 3, naznačen time što sadrži miješanje bakterijske vrste Roseburia hominis sa nutritivno prihvatljivim ekscipijensom, nosačem ili diluentom.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1117313.5A GB201117313D0 (en) | 2011-10-07 | 2011-10-07 | Bacterium for use in medicine |
| PCT/GB2012/052495 WO2013050792A1 (en) | 2011-10-07 | 2012-10-08 | Bacterium for use as a probiotic for nutritional and medical applications |
| EP12775538.7A EP2763685B1 (en) | 2011-10-07 | 2012-10-08 | Bacterium for use as a probiotic for nutritional and medical applications |
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Families Citing this family (117)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPQ899700A0 (en) | 2000-07-25 | 2000-08-17 | Borody, Thomas Julius | Probiotic recolonisation therapy |
| US9603876B2 (en) | 2008-09-25 | 2017-03-28 | New York University | Compositions and methods for restoring gastrointestinal microbiota following antibiotic treatment |
| US9338515B2 (en) * | 2009-09-03 | 2016-05-10 | At&T Intellectual Property I, L.P. | Real-time and secured picture/video upload via a content delivery network |
| WO2011151941A1 (ja) | 2010-06-04 | 2011-12-08 | 国立大学法人東京大学 | 制御性ｔ細胞の増殖または集積を誘導する作用を有する組成物 |
| US11844720B2 (en) | 2011-02-04 | 2023-12-19 | Seed Health, Inc. | Method and system to reduce the likelihood of dental caries and halitosis |
| US10940169B2 (en) | 2015-11-30 | 2021-03-09 | Joseph E. Kovarik | Method for reducing the likelihood of developing cancer in an individual human being |
| US11951140B2 (en) | 2011-02-04 | 2024-04-09 | Seed Health, Inc. | Modulation of an individual's gut microbiome to address osteoporosis and bone disease |
| US11998479B2 (en) | 2011-02-04 | 2024-06-04 | Seed Health, Inc. | Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure |
| US11951139B2 (en) | 2015-11-30 | 2024-04-09 | Seed Health, Inc. | Method and system for reducing the likelihood of osteoporosis |
| GB201112091D0 (en) | 2011-07-14 | 2011-08-31 | Gt Biolog Ltd | Bacterial strains isolated from pigs |
| GB201117313D0 (en) | 2011-10-07 | 2011-11-16 | Gt Biolog Ltd | Bacterium for use in medicine |
| CN103082292B (zh) * | 2011-11-02 | 2015-03-04 | 深圳华大基因研究院 | 罗斯氏菌(Roseburia)在治疗和预防肥胖相关疾病中的应用 |
| CN108676774B (zh) | 2011-12-01 | 2023-05-09 | 国立大学法人东京大学 | 诱导调节性t细胞的增殖或积累的人源细菌 |
| AU2013240289B2 (en) | 2012-03-29 | 2018-01-25 | Therabiome, Llc | Gastrointestinal site-specific oral vaccination formulations active on the ileum and appendix |
| KR102617655B1 (ko) | 2012-11-23 | 2023-12-27 | 세레스 테라퓨틱스, 인코포레이티드 | 상승작용적 박테리아 조성물, 그리고 이의 제조 방법 및 용도 |
| US8906668B2 (en) | 2012-11-23 | 2014-12-09 | Seres Health, Inc. | Synergistic bacterial compositions and methods of production and use thereof |
| EP2951283A4 (en) | 2013-02-04 | 2017-01-25 | Seres Therapeutics, Inc. | Compositions and methods |
| KR20230110367A (ko) | 2013-02-04 | 2023-07-21 | 세레스 테라퓨틱스, 인코포레이티드 | 조성물 및 방법 |
| NZ711298A (en) | 2013-03-14 | 2021-07-30 | Therabiome Llc | Targeted gastrointestinal tract delivery of probiotic organisms and/or therapeutic agents |
| EP2967077A4 (en) | 2013-03-15 | 2016-09-14 | Seres Therapeutics Inc | MICROBIAL COMPOSITIONS AND ASSOCIATED METHODS BASED ON A NETWORK |
| GB201306536D0 (en) * | 2013-04-10 | 2013-05-22 | Gt Biolog Ltd | Polypeptide and immune modulation |
| WO2014201037A2 (en) * | 2013-06-10 | 2014-12-18 | New York University | Methods for manipulating immune responses by altering microbiota |
| WO2015006355A2 (en) * | 2013-07-09 | 2015-01-15 | Puretech Ventures, Llc | Compositions containing combinations of bioactive molecules derived from microbiota for treatment of disease |
| US10258655B2 (en) | 2013-11-25 | 2019-04-16 | Seres Therapeutics, Inc. | Synergistic bacterial compositions and methods of production and use thereof |
| WO2015095241A2 (en) * | 2013-12-16 | 2015-06-25 | Seres Health, Inc. | Bacterial compositions and methods of use thereof for treatment of immune system disorders |
| US11213552B2 (en) | 2015-11-30 | 2022-01-04 | Joseph E. Kovarik | Method for treating an individual suffering from a chronic infectious disease and cancer |
| US12005085B2 (en) | 2013-12-20 | 2024-06-11 | Seed Health, Inc. | Probiotic method and composition for maintaining a healthy vaginal microbiome |
| US11529379B2 (en) | 2013-12-20 | 2022-12-20 | Seed Health, Inc. | Method and system for reducing the likelihood of developing colorectal cancer in an individual human being |
| US11969445B2 (en) | 2013-12-20 | 2024-04-30 | Seed Health, Inc. | Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH |
| US11672835B2 (en) | 2013-12-20 | 2023-06-13 | Seed Health, Inc. | Method for treating individuals having cancer and who are receiving cancer immunotherapy |
| US11026982B2 (en) | 2015-11-30 | 2021-06-08 | Joseph E. Kovarik | Method for reducing the likelihood of developing bladder or colorectal cancer in an individual human being |
| US11833177B2 (en) | 2013-12-20 | 2023-12-05 | Seed Health, Inc. | Probiotic to enhance an individual's skin microbiome |
| US11980643B2 (en) | 2013-12-20 | 2024-05-14 | Seed Health, Inc. | Method and system to modify an individual's gut-brain axis to provide neurocognitive protection |
| US11998574B2 (en) | 2013-12-20 | 2024-06-04 | Seed Health, Inc. | Method and system for modulating an individual's skin microbiome |
| US11839632B2 (en) | 2013-12-20 | 2023-12-12 | Seed Health, Inc. | Topical application of CRISPR-modified bacteria to treat acne vulgaris |
| US11642382B2 (en) | 2013-12-20 | 2023-05-09 | Seed Health, Inc. | Method for treating an individual suffering from bladder cancer |
| US11826388B2 (en) | 2013-12-20 | 2023-11-28 | Seed Health, Inc. | Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation |
| WO2015175388A1 (en) * | 2014-05-12 | 2015-11-19 | Rush University Medical Center | Biomarkers for risk assessment, diagnosis and target microbiome and intestinal homeostasis for prevention and treatment of amyotrophic lateral sclerosis |
| EP3881680A1 (en) | 2014-10-31 | 2021-09-22 | Pendulum Therapeutics, Inc. | Methods and compositions relating to microbial treatment |
| MA41020A (fr) | 2014-11-25 | 2017-10-03 | Evelo Biosciences Inc | Compositions probiotiques et prébiotiques, et leurs procédés d'utilisation pour la modulation du microbiome |
| WO2016102951A1 (en) | 2014-12-23 | 2016-06-30 | 4D Pharma Research Limited | Pirin polypeptide and immune modulation |
| ME02997B (me) | 2014-12-23 | 2018-10-20 | 4D Pharma Res Ltd | Soj bacteroides thetaiotaomicron i njegova upotreba u smanjenju inflamacije |
| PL3206700T3 (pl) | 2015-06-15 | 2019-11-29 | 4D Pharma Res Ltd | Kompozycje zawierające szczepy bakteryjne |
| MA41010B1 (fr) | 2015-06-15 | 2020-01-31 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| CN115364122A (zh) | 2015-06-15 | 2022-11-22 | 4D制药研究有限公司 | 包含细菌菌株的组合物 |
| MA41060B1 (fr) | 2015-06-15 | 2019-11-29 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| MD3307288T2 (ro) * | 2015-06-15 | 2019-12-31 | 4D Pharma Res Ltd | Compoziții care conțin tulpini bacteriene |
| US9765358B2 (en) * | 2015-11-17 | 2017-09-19 | SciBac Inc. | Method for producing chimeric microbial hybrids |
| GB201520497D0 (en) | 2015-11-20 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| EA034677B1 (ru) | 2015-11-20 | 2020-03-05 | 4Д Фарма Рисёрч Лимитед | Композиции для лечения или профилактики рака, содержащие штамм enterococcus gallinarum |
| GB201520638D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| GB201520631D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| MX2018009539A (es) | 2016-02-04 | 2019-02-11 | Univ Gent | Uso de comunidades microbianas para la salud humana y animal. |
| DK3313423T3 (da) | 2016-03-04 | 2019-05-20 | 4D Pharma Plc | Sammensætninger omfattende bakterielle blautia-stammer til behandling af visceral hypersensitivitet |
| GB201612191D0 (en) | 2016-07-13 | 2016-08-24 | 4D Pharma Plc | Compositions comprising bacterial strains |
| WO2017223273A1 (en) * | 2016-06-22 | 2017-12-28 | President And Fellows Of Harvard College | Inhibition of colonic group 3 innate lymphoid cells |
| KR101779370B1 (ko) | 2016-06-29 | 2017-09-19 | 한국수력원자력 주식회사 | 방사선 조사 된 흉선 림프종 세포에서 발굴 된 세포고사 조절 유전자 및 그 검출방법 |
| TWI802545B (zh) | 2016-07-13 | 2023-05-21 | 英商４Ｄ製藥有限公司 | 包含細菌菌株之組合物 |
| US10653728B2 (en) | 2016-10-17 | 2020-05-19 | New York University | Probiotic compositions for improving metabolism and immunity |
| CN110352236A (zh) * | 2016-11-01 | 2019-10-18 | 学校法人庆应义塾 | 诱导Th1细胞的细菌 |
| GB201621123D0 (en) | 2016-12-12 | 2017-01-25 | 4D Pharma Plc | Compositions comprising bacterial strains |
| WO2018159787A1 (ja) | 2017-03-01 | 2018-09-07 | 国立大学法人北海道大学 | 疾患モデル非ヒト動物の製造方法、疾患モデル非ヒト動物、該動物を用いた薬剤のスクリーニング方法及び疾患リスク判定方法 |
| EP3369423A1 (en) | 2017-03-01 | 2018-09-05 | Reminisciences | Synbiotic composition and its use for preventing and/or treating neurodegenerative disorders |
| US11666627B2 (en) | 2017-04-07 | 2023-06-06 | Second Genome, Inc. | Proteins for the treatment of epithelial barrier function disorders |
| MX2019012051A (es) * | 2017-04-07 | 2020-02-12 | Second Genome Inc | Proteinas para el tratamiento de trastornos de la funcion de la barrera epitelial. |
| LT3630136T (lt) | 2017-05-22 | 2021-06-10 | 4D Pharma Research Limited | Kompozicijos, apimančios bakterines padermes |
| WO2018215782A1 (en) | 2017-05-24 | 2018-11-29 | 4D Pharma Research Limited | Compositions comprising bacterial strain |
| HUE052258T2 (hu) | 2017-06-14 | 2021-04-28 | 4D Pharma Res Ltd | Megasphaera nemzetségbe tartozó baktériumtörzset tartalmazó készítmény, és alkalmazása |
| IL283973B (en) | 2017-06-14 | 2022-08-01 | 4D Pharma Res Ltd | Preparations containing bacterial strains |
| EP3638271B1 (en) * | 2017-06-14 | 2020-10-14 | 4D Pharma Research Limited | Compositions comprising bacterial strains |
| JP2020529478A (ja) * | 2017-08-04 | 2020-10-08 | セカンド ゲノム インコーポレイテッド | バイオ治療薬としてのロゼブリア・ホミニス（ｒｏｓｅｂｕｒｉａ ｈｏｍｉｎｉｓ）、ユーバクテリウム・エリゲンス（ｅｕｂａｃｔｅｒｉｕｍ ｅｌｉｇｅｎｓ）、およびこれらの組み合わせ |
| KR102680943B1 (ko) | 2017-08-14 | 2024-07-03 | 세레스 테라퓨틱스, 인코포레이티드 | 담즙정체성 질환 치료를 위한 조성물 및 방법 |
| CA3073838A1 (en) | 2017-08-30 | 2019-03-07 | Pendulum Therapeutics, Inc. | Methods and compositions for treatment of microbiome-associated disorders |
| US11510948B2 (en) | 2017-09-28 | 2022-11-29 | Kobiolabs, Inc. | Composition for diagnosis and treatment of alcoholic liver disease, using change in short-chain fatty acid producing gut bacterial community |
| CA3088630A1 (en) | 2017-12-15 | 2019-06-20 | Solarea Bio, Inc. | Microbial compositions and methods for treating type 2 diabetes, obesity, and metabolic syndrome |
| CN109957528A (zh) * | 2017-12-26 | 2019-07-02 | 大连医科大学 | 可调节免疫耐受发育延缓变应性进程的菌株 |
| CN111902153A (zh) | 2018-01-19 | 2020-11-06 | 4D制药研究有限公司 | 用于治疗或预防癌症的组合疗法 |
| WO2019141996A1 (en) | 2018-01-19 | 2019-07-25 | 4D Pharma Research Limited | Combination therapy for treating or preventing cancer |
| MX2020007664A (es) | 2018-01-19 | 2020-09-14 | 4D Pharma Res Limited | Terapia de combinacion para tratar o prevenir el cancer. |
| MX2020007681A (es) | 2018-01-19 | 2020-09-14 | 4D Pharma Res Limited | Terapia de combinacion para tratar o prevenir el cancer. |
| HUE058151T2 (hu) | 2018-03-19 | 2022-07-28 | 4D Pharma Res Ltd | Enterococcusból származó flagellin készítményei terápiában történõ alkalmazásra |
| US11505583B2 (en) | 2018-04-06 | 2022-11-22 | Second Genome, Inc. | Proteins for the treatment of epithelial barrier function disorders |
| CN112601534A (zh) | 2018-05-11 | 2021-04-02 | 4D制药研究有限公司 | 包含细菌菌株的组合物 |
| AU2019287370A1 (en) | 2018-06-14 | 2021-01-07 | 4D Pharma Research Ltd | Compositions comprising bacterial strains |
| KR20210021461A (ko) | 2018-06-19 | 2021-02-26 | 4디 파마 리서치 리미티드 | 살아있는 바이오치료 제품을 포함하는 제형 |
| EP3922256A1 (en) | 2018-06-25 | 2021-12-15 | 4D Pharma Research Limited | Compositions comprising bacterial strains |
| FR3083545A1 (fr) * | 2018-07-04 | 2020-01-10 | Institut National De La Recherche Agronomique | Utilisation d'une souche de roseburia intestinalis pour la prevention et le traitement de l'inflammation de l'intestin |
| TW202019447A (zh) | 2018-07-16 | 2020-06-01 | 英商4D製藥研究有限公司 | 包含細菌菌株之組合物 |
| US20210405011A1 (en) * | 2018-09-01 | 2021-12-30 | National University Corporation Hokkaido University | Pharmaceutical for preventing and/or treating stress load-related disease |
| US11980647B2 (en) | 2018-09-05 | 2024-05-14 | Solarea Bio, Inc. | Methods and compositions for treating musculoskeletal diseases, treating inflammation, and managing symptoms of menopause |
| CA3111795A1 (en) | 2018-09-05 | 2020-03-12 | Solarea Bio, Inc. | Methods and compositions for treating musculoskeletal diseases |
| US11590182B2 (en) | 2018-09-10 | 2023-02-28 | Ohio State Innovation Foundation | Methods and compositions to modulate antibiotic resistance and gastrointestinal microbiota |
| WO2020058499A1 (en) | 2018-09-20 | 2020-03-26 | 4D Pharma Research Limited | Compositions comprising bacterial strains |
| EP3863653A1 (en) | 2018-10-09 | 2021-08-18 | 4D Pharma Research Limited | Compositions comprising bacterial strains |
| WO2020079282A1 (en) | 2018-10-19 | 2020-04-23 | 4D Pharma Research Ltd | Compositions comprising bacterial strains |
| CN114025794A (zh) | 2018-11-02 | 2022-02-08 | 4D制药研究有限公司 | 包含细菌菌株的组合物 |
| WO2020117997A1 (en) | 2018-12-05 | 2020-06-11 | The Procter & Gamble Company | Container for personal health compositions |
| WO2020120717A1 (en) | 2018-12-12 | 2020-06-18 | 4D Pharma Research Limited | Compositions comprising parabacteroides bacterial strains for treating cancer |
| JP2022511975A (ja) | 2018-12-12 | 2022-02-01 | フォーディー ファーマ リサーチ リミテッド | 細菌株を含む組成物 |
| EP3893905A1 (en) | 2018-12-12 | 2021-10-20 | 4D Pharma Research Limited | Compositions comprising bacterial strains |
| US20220088092A1 (en) * | 2019-01-21 | 2022-03-24 | The Broad Institute, Inc. | Compositions and methods for increasing the viability of freeze-dried probiotics |
| CN110037127A (zh) * | 2019-04-23 | 2019-07-23 | 彤博士健康产业河北有限公司 | 一种调理婴幼儿肠道的益生菌制剂及其制备方法 |
| US12059441B2 (en) | 2019-05-01 | 2024-08-13 | International N&H Denmark Aps | Probiotic bacterial strains that produce short chain fatty acids and compositions comprising same |
| MA54871A (fr) | 2019-05-10 | 2022-05-11 | 4D Pharma Res Ltd | Compositions comprenant des blautia hydrogenotrophica dans le traitement de fibromyalgie |
| JP2022540576A (ja) | 2019-07-05 | 2022-09-16 | フォーディー ファーマ リサーチ リミテッド | 細菌株を含む組成物 |
| US11622981B2 (en) | 2019-08-23 | 2023-04-11 | Wake Forest University Health Sciences | Bacterial strain useful for treatment of age-related conditions |
| WO2021098991A1 (en) | 2019-11-20 | 2021-05-27 | 4D Pharma Research Limited | Compositions comprising bacterial strains |
| EP3839039A1 (en) | 2019-12-16 | 2021-06-23 | 4D Pharma Research Limited | Providing bacterial biomass with improved storage stability |
| EP3838281A1 (en) | 2019-12-20 | 2021-06-23 | 4D Pharma Research Limited | Compositions comprising bacterial strains |
| TW202140773A (zh) | 2020-01-27 | 2021-11-01 | 英商4D製藥研究有限公司 | 包含細菌菌株之組成物 |
| TW202220639A (zh) | 2020-08-06 | 2022-06-01 | 英商４Ｄ製藥有限公司 | 凍乾方法 |
| AU2021386691A1 (en) | 2020-11-26 | 2023-07-06 | 4D Pharma Leon, S.L.U. | Process |
| CN114748513A (zh) * | 2020-12-29 | 2022-07-15 | 中国医学科学院放射医学研究所 | 肠道罗斯拜瑞氏菌在制备肿瘤的放射增敏剂中的用途 |
| TWI778616B (zh) * | 2021-05-06 | 2022-09-21 | 財團法人食品工業發展研究所 | 具有高丁酸生產能力的人羅斯拜瑞氏菌hgm001分離株及其用途 |
| US12011467B2 (en) | 2021-05-18 | 2024-06-18 | J. Craig Venter Institute, Inc. | Bacterial formulation |
| EP4436407A1 (en) | 2021-11-22 | 2024-10-02 | Solarea Bio, Inc. | Methods and compositions for treating musculoskeletal diseases, treating inflammation, and managing symptoms of menopause |
| US20230190834A1 (en) | 2021-12-21 | 2023-06-22 | Solarea Bio, Inc. | Immunomodulatory compositions comprising microbial entities |
Family Cites Families (361)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| NL8300698A (nl) | 1983-02-24 | 1984-09-17 | Univ Leiden | Werkwijze voor het inbouwen van vreemd dna in het genoom van tweezaadlobbige planten; agrobacterium tumefaciens bacterien en werkwijze voor het produceren daarvan; planten en plantecellen met gewijzigde genetische eigenschappen; werkwijze voor het bereiden van chemische en/of farmaceutische produkten. |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| DK122686D0 (da) | 1986-03-17 | 1986-03-17 | Novo Industri As | Fremstilling af proteiner |
| FR2613624B1 (fr) | 1987-04-10 | 1990-11-23 | Roussy Inst Gustave | Composition pharmaceutique, administrable par voie orale, destinee a reduire les effets des b-lactamines |
| US5443826A (en) | 1988-08-02 | 1995-08-22 | Borody; Thomas J. | Treatment of gastro-intestinal disorders with a fecal composition or a composition of bacteroides and E. Coli |
| EP0433299B1 (en) | 1988-08-02 | 1998-05-06 | Gastro Services Pty. Limited (ACN 002 994 890) | Treatment of gastro-intestinal disorders |
| KR100225087B1 (ko) | 1990-03-23 | 1999-10-15 | 한스 발터라벤 | 피타아제의 식물내 발현 |
| AU639570B2 (en) | 1990-05-09 | 1993-07-29 | Novozymes A/S | A cellulase preparation comprising an endoglucanase enzyme |
| GB9107305D0 (en) | 1991-04-08 | 1991-05-22 | Unilever Plc | Probiotic |
| US5443951A (en) | 1992-07-20 | 1995-08-22 | Kabushiki Kaisha Yakult Honsha | Species-specific oligonucleotides for bifidobacteria and a method of detection using the same |
| JPH08504327A (ja) | 1992-12-10 | 1996-05-14 | ギスト ブロカデス ナムローゼ フェンノートシャップ | 糸状菌における異種タンパクの生産 |
| US5741665A (en) | 1994-05-10 | 1998-04-21 | University Of Hawaii | Light-regulated promoters for production of heterologous proteins in filamentous fungi |
| US5599795A (en) | 1994-08-19 | 1997-02-04 | Mccann; Michael | Method for treatment of idiopathic inflammatory bowel disease (IIBD) |
| AUPM823094A0 (en) | 1994-09-16 | 1994-10-13 | Goodman Fielder Limited | Probiotic compositions |
| AUPM864894A0 (en) | 1994-10-07 | 1994-11-03 | Borody, Thomas Julius | Treatment of bowel-dependent neurological disorders |
| RU2078815C1 (ru) | 1995-01-17 | 1997-05-10 | Московский научно-исследовательский институт эпидемиологии и микробиологии им.Г.Н.Габричевского | Штамм бактерий bifidobacterium breve, используемый для получения бактерийных лечебно-профилактических бифидосодержащих препаратов |
| JPH08259450A (ja) | 1995-03-17 | 1996-10-08 | Nichinichi Seiyaku Kk | インターフェロン産生増強剤 |
| US6861053B1 (en) | 1999-08-11 | 2005-03-01 | Cedars-Sinai Medical Center | Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth |
| AUPN698495A0 (en) | 1995-12-06 | 1996-01-04 | Pharma Pacific Pty Ltd | Improved therapeutic formulation and method |
| SE508045C2 (sv) | 1996-02-26 | 1998-08-17 | Arla Ekonomisk Foerening | Adhesionsinhibitorer, preparat innehållande desamma och förfarande för framställning därav |
| AUPN881396A0 (en) | 1996-03-20 | 1996-04-18 | Arnott's Biscuits Limited | Enhancement of microbial colonization of the gastrointestinal tract |
| JP4282763B2 (ja) | 1996-03-20 | 2009-06-24 | ザ、ユニバーシティ、オブ、ニュー、サウス、ウェイルズ | 消化管内の微生物個体数の変更 |
| WO1997035956A1 (en) | 1996-03-27 | 1997-10-02 | Novo Nordisk A/S | Alkaline protease deficient filamentous fungi |
| US6033864A (en) | 1996-04-12 | 2000-03-07 | The Regents Of The University Of California | Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using microbial UC pANCA antigens |
| WO1998043081A1 (en) | 1997-03-26 | 1998-10-01 | Ligand Pharmaceuticals Incorporated | Treatment of gastrointestinal disease with ppar modulators |
| SE511524C2 (sv) | 1997-06-02 | 1999-10-11 | Essum Ab | Lactobacillus casei rhamnosus-stam samt farmaceutisk beredning för bekämpning av patogena tarmbakterier |
| US5925657A (en) | 1997-06-18 | 1999-07-20 | The General Hospital Corporation | Use of PPARγ agonists for inhibition of inflammatory cytokine production |
| AUPO758297A0 (en) | 1997-06-27 | 1997-07-24 | Rowe, James Baber | Control of acidic gut syndrome |
| US5951977A (en) | 1997-10-14 | 1999-09-14 | The United States Of America, As Represented By The Secretary Of Agriculture | Competitive exclusion culture for swine |
| IT1298918B1 (it) | 1998-02-20 | 2000-02-07 | Mendes Srl | Uso di batteri dotati di arginina deiminasi per indurre apoptosi e/o ridurre una reazione infiammatoria e composizioni farmaceutiche |
| DE19826928A1 (de) | 1998-06-17 | 1999-12-23 | Novartis Consumer Health Gmbh | Arzneimittel, lebensfähige anaerobe Bakterien enthaltend, die die Sulfatreduktion sulfatreduzierender Bakterien hemmen |
| ID29150A (id) | 1999-01-15 | 2001-08-02 | Entpr Ireland Cs | Penggunaan lactobacillus salivarius |
| US7090973B1 (en) | 1999-04-09 | 2006-08-15 | Oscient Pharmaceuticals Corporation | Nucleic acid sequences relating to Bacteroides fragilis for diagnostics and therapeutics |
| JP2003508389A (ja) | 1999-08-27 | 2003-03-04 | エリ リリー アンド カンパニー | ビアリール−オキサ（チア）ゾール誘導体およびそのｐｐａｒモジュレーターとしての使用 |
| BR0108164B1 (pt) | 2000-02-08 | 2014-06-17 | Dsm Ip Assets Bv | Uso de pelo menos uma protease estável em ácido, processo para melhorar o valor nutritivo de um alimento para animal, aditivo de alimento para animal, composição de alimento para animal, e, processo para tratar proteínas vegetais para uso em alimento para animal. |
| FR2808689B1 (fr) | 2000-05-11 | 2004-09-03 | Agronomique Inst Nat Rech | Utilisation de souches acetogenes hydrogenotrophes pour la prevention ou le traitement de troubles digestifs |
| US20020013270A1 (en) | 2000-06-05 | 2002-01-31 | Bolte Ellen R. | Method for treating a mental disorder |
| AUPQ899700A0 (en) | 2000-07-25 | 2000-08-17 | Borody, Thomas Julius | Probiotic recolonisation therapy |
| WO2002042328A2 (en) | 2000-11-27 | 2002-05-30 | Washington University | Method for studying the effects of commensal microflora on mammalian intestine and treatments of gastrointestinal-associated disease based thereon |
| DE10101793A1 (de) | 2001-01-17 | 2002-08-01 | Manfred Nilius | Verwendung von SLPI zur Behandlung chronisch-entzündlicher Darmerkrankungen |
| EP1227152A1 (en) | 2001-01-30 | 2002-07-31 | Société des Produits Nestlé S.A. | Bacterial strain and genome of bifidobacterium |
| KR100437497B1 (ko) | 2001-03-07 | 2004-06-25 | 주식회사 프로바이오닉 | 로타바이러스 및 유해 미생물 억제 활성을 가지는 신규내산성 락토바실러스 루테리 프로바이오-16 및 이를함유하는 생균활성제 |
| EP1243273A1 (en) | 2001-03-22 | 2002-09-25 | Societe Des Produits Nestle S.A. | Composition comprising a prebiotic for decreasing infammatory process and abnormal activation of non-specific immune parameters |
| EP1379552B2 (en) | 2001-04-20 | 2014-11-19 | The Institute for Systems Biology | Toll-like receptor 5 ligands and methods of use |
| EP1260227A1 (en) | 2001-05-23 | 2002-11-27 | Societe Des Produits Nestle S.A. | Lipoteichoic acid from lactic acid bacteria and its use to modulate immune responses mediated by gram-negative bacteria, potential pathogenic gram-positive bacteria |
| US20030092163A1 (en) | 2001-07-26 | 2003-05-15 | Collins John Kevin | Probiotic bifidobacterium strains |
| MXPA04001999A (es) | 2001-09-05 | 2004-07-16 | Vsl Pharmaceuticals Inc | Bacterias de acido lactico que comprende dinucleotidos de citosina-guanina no metilados para usarse en terapia. |
| GB0127916D0 (en) | 2001-11-21 | 2002-01-16 | Rowett Res Inst | Method |
| AU2002346504A1 (en) | 2001-11-27 | 2003-06-10 | Astrazeneca Ab | Therapeutic protein and treatments |
| CA2476755C (en) | 2001-12-17 | 2014-08-26 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of inflammatory bowel disease |
| US7101565B2 (en) | 2002-02-05 | 2006-09-05 | Corpak Medsystems, Inc. | Probiotic/prebiotic composition and delivery method |
| DE10206995B4 (de) | 2002-02-19 | 2014-01-02 | Orthomol Pharmazeutische Vertriebs Gmbh | Mikronährstoffkombinationsprodukt mit Pro- und Prebiotika |
| JP2003261453A (ja) | 2002-03-11 | 2003-09-16 | Nippon Berumu Kk | Ｅ．フェカリスからなる抗腫瘍剤及び放射線防護剤 |
| WO2004003235A2 (en) | 2002-06-28 | 2004-01-08 | Puleva Biotech, S.A. | Probiotic strains, a process for the selection of them, compositions thereof, and their use |
| US20040005304A1 (en) | 2002-07-08 | 2004-01-08 | Mak Wood, Inc. | Novel compositions and methods for treating neurological disorders and associated gastrointestinal conditions |
| GB0307026D0 (en) * | 2003-03-27 | 2003-04-30 | Rowett Res Inst | Bacterial supplement |
| EP1481681A1 (en) | 2003-05-30 | 2004-12-01 | Claudio De Simone | Lactic acid bacteria combination and compositions thereof |
| GB0316915D0 (en) | 2003-07-18 | 2003-08-20 | Glaxo Group Ltd | Compounds |
| AU2003247193A1 (en) | 2003-07-23 | 2005-02-04 | M.D.Lab Corp. | Acid tolerant probiotic lactobacillus plantarum probio-38 that can suppress the growth of pathogenic microorganism and tge coronavirus |
| US7485325B2 (en) | 2003-08-06 | 2009-02-03 | Gayle Dorothy Swain | Animal food supplement compositions and methods of use |
| JP4683881B2 (ja) | 2003-08-27 | 2011-05-18 | 有限会社アーク技研 | 抗腫瘍活性剤 |
| US8192733B2 (en) | 2003-08-29 | 2012-06-05 | Cobb & Associates | Probiotic composition useful for dietary augmentation and/or combating disease states and adverse physiological conditions |
| US20050163764A1 (en) | 2003-09-22 | 2005-07-28 | Yale University | Treatment with agonists of toll-like receptors |
| GB0323039D0 (en) | 2003-10-01 | 2003-11-05 | Danisco | Method |
| ES2314461T3 (es) | 2003-10-24 | 2009-03-16 | N.V. Nutricia | Composicion simbiotica para bebes. |
| US20050239706A1 (en) | 2003-10-31 | 2005-10-27 | Washington University In St. Louis | Modulation of fiaf and the gastrointestinal microbiota as a means to control energy storage in a subject |
| CA2550106A1 (en) | 2003-12-17 | 2005-06-30 | N.V. Nutricia | Lactic acid producing bacteria and lung function |
| ES2235642B2 (es) | 2003-12-18 | 2006-03-01 | Gat Formulation Gmbh | Proceso de multi-microencapsulacion continuo para la mejora de la estabilidad y almacenamiento de ingredientes biologicamente activos. |
| WO2005093049A1 (en) | 2004-03-22 | 2005-10-06 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Cellular and viral inactivation |
| JP2007535924A (ja) | 2004-05-07 | 2007-12-13 | − グスタフ ユングレン、ハンス | ワクチン用アジュバントとしてのフラジェリンの使用 |
| US7638513B2 (en) | 2004-06-02 | 2009-12-29 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
| PE20060426A1 (es) | 2004-06-02 | 2006-06-28 | Schering Corp | DERIVADOS DE ACIDO TARTARICO COMO INHIBIDORES DE MMPs, ADAMs, TACE Y TNF-alfa |
| NZ586338A (en) | 2004-06-07 | 2012-02-24 | Qu Biolog Inc | Bacterial compositions for the treatment of cancer |
| ES2286558T5 (es) | 2004-08-24 | 2013-10-15 | N.V. Nutricia | Composición nutritiva que comprende transgalactooligosacáridos indigeribles y sacáridos de galactosa digeribles |
| US20060062742A1 (en) | 2004-09-21 | 2006-03-23 | The Procter & Gamble Company | Compositions for reduction of human malodor |
| KR100468522B1 (ko) | 2004-10-12 | 2005-01-31 | 주식회사 프로바이오닉 | 코로나바이러스와 돼지 써코바이러스 2형의 생육을 억제하는 신규한 내산성 프로바이오틱 엔테로코커스훼시움 프로바이오-63 |
| US20060115465A1 (en) | 2004-10-29 | 2006-06-01 | Macfarlane George | Treatment of gastrointestinal disorders |
| ITMI20042189A1 (it) | 2004-11-16 | 2005-02-16 | Anidral Srl | Composizione a base di batteri probiotici e suo uso nella prevenzione e-o nel trattamento di patologie e-o infezioni respiratorie e nel miglioramento della funzionalita' intestinale |
| ES2524344T3 (es) | 2005-02-28 | 2014-12-05 | N.V. Nutricia | Composición nutritiva con probióticos |
| WO2006102536A2 (en) | 2005-03-23 | 2006-09-28 | University Of Southern California | Treatment of disease conditions through modulation of hydrogen sulfide produced by small intestinal bacterial overgrowth |
| WO2006102350A1 (en) | 2005-03-23 | 2006-09-28 | Washington University In St. Louis | The use of archaea to modulate the nutrient harvesting functions of the gastrointestinal microbiota |
| JP2006265212A (ja) | 2005-03-25 | 2006-10-05 | Institute Of Physical & Chemical Research | Ｉｌ−２１産生誘導剤 |
| US20100233312A9 (en) | 2005-04-11 | 2010-09-16 | The Procter & Gamble Company | Compositions comprising probiotic and sweetener components |
| EP1714660A1 (en) | 2005-04-21 | 2006-10-25 | N.V. Nutricia | Uronic acid and probiotics |
| US8603461B2 (en) | 2005-04-26 | 2013-12-10 | TEAGASC—The Agriculture and Food Development Authority | Probiotic composition suitable for animals |
| NZ563193A (en) | 2005-05-09 | 2010-05-28 | Ono Pharmaceutical Co | Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics |
| US7572474B2 (en) | 2005-06-01 | 2009-08-11 | Mead Johnson Nutrition Company | Method for simulating the functional attributes of human milk oligosaccharides in formula-fed infants |
| US8075934B2 (en) | 2008-10-24 | 2011-12-13 | Mead Johnson Nutrition Company | Nutritional composition with improved digestibility |
| JP2007084533A (ja) | 2005-08-24 | 2007-04-05 | Prima Meat Packers Ltd | 免疫応答調節組成物及び該組成物を有効成分とする食品 |
| US7625704B2 (en) | 2005-08-31 | 2009-12-01 | Fred Hutchinson Cancer Research Center | Methods and compositions for identifying bacteria associated with bacteria vaginosis |
| CN101296706B (zh) | 2005-09-01 | 2011-11-30 | 先灵公司 | Il-23和il-17拮抗剂治疗自身免疫性眼部炎性疾病的用途 |
| US20090028840A1 (en) | 2005-09-23 | 2009-01-29 | Gwangju Institute Of Sciecne And Technology | Compositions For Preventing Or Treating Arthritis Comprising Lactic Acid Bacteria and Collangen As Active Ingredients |
| WO2007039313A2 (en) | 2005-10-06 | 2007-04-12 | Nestec S.A. | Probiotic enterococci for improved immunity |
| EP1776877A1 (en) | 2005-10-21 | 2007-04-25 | N.V. Nutricia | Method for stimulating the intestinal flora |
| MY144556A (en) | 2005-10-24 | 2011-09-30 | Nestec Sa | Dietary fiber formulation and method of administration |
| JP2007116991A (ja) | 2005-10-28 | 2007-05-17 | Eternal Light General Institute Inc | 機能性食品 |
| US7767420B2 (en) | 2005-11-03 | 2010-08-03 | Momenta Pharmaceuticals, Inc. | Heparan sulfate glycosaminoglycan lyase and uses thereof |
| AU2006320604A1 (en) | 2005-12-01 | 2007-06-07 | Schering Corporation | Compounds for the treatment of inflammatory disorders and microbial diseases |
| US8889149B2 (en) | 2006-02-16 | 2014-11-18 | Wayne State University | Use of flagellin to prevent and treat gram negative bacterial infection |
| US20080260906A1 (en) | 2006-03-17 | 2008-10-23 | Marko Stojanovic | Compositions comprising probiotic and sweetener components |
| JP5031249B2 (ja) | 2006-03-22 | 2012-09-19 | 学校法人北里研究所 | 炎症抑制作用のある菌体含有組成物 |
| WO2007126990A2 (en) | 2006-03-29 | 2007-11-08 | Nestec S.A. | Dietary supplements containing probiotics |
| CA2652559A1 (en) | 2006-05-18 | 2007-11-29 | Biobalance Llc | Biotherapeutic compositions and uses thereof |
| CA2655665A1 (en) | 2006-05-26 | 2007-12-06 | Nestec S.A. | Methods of use and nutritional compositions of touchi extract |
| WO2007140613A1 (en) | 2006-06-06 | 2007-12-13 | Mcgill University | Fermented milk product and use thereof |
| TW200819540A (en) | 2006-07-11 | 2008-05-01 | Genelux Corp | Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders |
| US8691213B2 (en) | 2006-08-04 | 2014-04-08 | SHS International | Protein free formula |
| WO2008031438A2 (en) | 2006-09-13 | 2008-03-20 | Region Hovedstaden V/Gentofte Hospital | Treatment of asthma, eczema and/or allergy using non-pathogenic organisms |
| US20080069861A1 (en) | 2006-09-19 | 2008-03-20 | National Starch And Chemical Investment Holding Corporation | Probiotic/Non-Probiotic Combinations |
| KR20120038021A (ko) | 2006-10-27 | 2012-04-20 | 화이자 프로덕츠 인코포레이티드 | 하이드록시프로필 메틸 셀룰로스 경질 캡슐 및 이의 제조 방법 |
| WO2008053444A2 (en) | 2006-11-01 | 2008-05-08 | The Procter & Gamble Company | Treating a respiratory condition with bifidobacterium |
| PL1920781T3 (pl) | 2006-11-10 | 2015-06-30 | Glycotope Gmbh | Kompozycje zawierające core-1-dodatnie mikroorganizmy i ich zastosowanie w leczeniu lub profilaktyce nowotworów |
| WO2008064489A1 (en) | 2006-12-01 | 2008-06-05 | Mcmaster University | Probiotics to inhibit inflammation |
| EP2102350A4 (en) | 2006-12-18 | 2012-08-08 | Univ St Louis | INTESTINAL MICROBIOMA AS A BIOMARKER AND THERAPEUTIC TARGET FOR TREATING OBESITY OR OBESITY-RELATED DISORDER |
| DE102006062250A1 (de) | 2006-12-22 | 2008-06-26 | Roland Saur-Brosch | Verwendung einer Zusammensetzung aus Mineralstoffen und/oder Vitaminen und gegebenenfalls acetogenen und/oder butyrogenen Bakterien zur oralen oder rektalen Verabreichung für die Behandlung und Vorbeugung von abdominalen Beschwerden |
| WO2008083157A2 (en) | 2006-12-29 | 2008-07-10 | Washington University In St. Louis | Altering pgc-1alapha, ampk, fiaf, or the gastrointestinal microbiota as a means to modulate body fat and/or weight loss in a subject |
| JP2008195635A (ja) | 2007-02-09 | 2008-08-28 | Crossfield Bio Inc | 馬用乳酸菌製剤 |
| MX2009008875A (es) | 2007-02-28 | 2009-08-28 | Mead Johnson Nutrition Co | Producto que contiene probiotico inactivado para niños o infantes. |
| JP5538209B2 (ja) | 2007-03-28 | 2014-07-02 | アリメンタリー・ヘルス・リミテッド | プロバイオティック性のビフィドバクテリウム菌株 |
| AU2008231467A1 (en) | 2007-03-28 | 2008-10-02 | Alimentary Health Limited | Probiotic Bifidobacterium strains |
| AU2008245685B2 (en) | 2007-04-24 | 2013-06-27 | Kemin Industries, Inc. | Broad-spectrum antibacterial and antifungal activity of Lactobacillus johnsonii D115 |
| EP1997499A1 (en) | 2007-05-31 | 2008-12-03 | Puleva Biotech, S.A. | Mammalian milk microorganisms, compositions containing them and their use for the treatment of mastitis |
| EP1997905A1 (en) | 2007-06-01 | 2008-12-03 | Friesland Brands B.V. | Nucleic acid amplification |
| EP1997907A1 (en) | 2007-06-01 | 2008-12-03 | Friesland Brands B.V. | Bifidobacteria |
| EP1997906A1 (en) | 2007-06-01 | 2008-12-03 | Friesland Brands B.V. | Lactobacillus |
| WO2008153377A1 (en) | 2007-06-15 | 2008-12-18 | N.V. Nutricia | Nutrition with non-viable bifidobacterium and non-digestible oligosaccharide |
| EP2179028B1 (en) | 2007-06-27 | 2014-08-13 | Laboratorios Ordesa, S.l. | A novel strain of bifidobacterium and active peptides against rotavirus infections |
| HUP0700552A2 (en) | 2007-08-27 | 2009-03-30 | Janos Dr Feher | Method and composition inhibiting inflammation |
| WO2009030254A1 (en) | 2007-09-04 | 2009-03-12 | Curevac Gmbh | Complexes of rna and cationic peptides for transfection and for immunostimulation |
| US20100284979A1 (en) | 2007-10-01 | 2010-11-11 | University College Cork, National University Of Ireland, Cork | Modulation of Tissue Fatty Acid Composition of a Host by Human Gut Bacteria |
| DK2203551T3 (da) | 2007-10-20 | 2013-10-28 | Univ Liege | Bifidobakterieart |
| ES2473625T3 (es) | 2007-10-26 | 2014-07-07 | Brenda E. Moore | Composición probi�tica y métodos para inducir y mantener la pérdida de peso |
| EP2205642B1 (en) | 2007-11-02 | 2016-01-27 | Momenta Pharmaceuticals, Inc. | Non-anticoagulant polysaccharide compositions |
| EP2065048A1 (en) | 2007-11-30 | 2009-06-03 | Institut Pasteur | Use of a L. casei strain, for the preparation of a composition for inhibiting mast cell activation |
| US9119414B2 (en) | 2007-12-07 | 2015-09-01 | N.V. Nutricia | Bifidobacterium for dust mite allergy |
| WO2009079564A2 (en) | 2007-12-17 | 2009-06-25 | Emory University | Immunogenic compositions and methods of use thereof |
| ES2343499B1 (es) | 2007-12-24 | 2011-06-10 | Consejo Superior De Investigaciones Cientificas | Microorganismos para mejorar el estado de salud de individuos con desordenes relacionados con la ingesta de gluten. |
| JP2011510684A (ja) | 2008-02-06 | 2011-04-07 | ザ プロクター アンド ギャンブル カンパニー | 呼吸器状態に対する免疫反応を強化するための組成物、方法、及びキット |
| EP2103226A1 (en) | 2008-03-18 | 2009-09-23 | Friesland Brands B.V. | Long-life probiotic food product |
| WO2009128950A2 (en) | 2008-04-18 | 2009-10-22 | Vaxinnate Corporation | Deletion mutants of flagellin and methods of use |
| CA2722738C (en) | 2008-05-13 | 2017-04-25 | Glycotope Gmbh | Fermentation process |
| MX2008006546A (es) | 2008-05-21 | 2009-11-23 | Sigma Alimentos Sa De Cv | Bifidobacteria productora de ácido fólico, composición alimenticia y uso de la bifidobacteria. |
| CN101590081A (zh) | 2008-05-28 | 2009-12-02 | 青岛东海药业有限公司 | 凸腹真杆菌和两形真杆菌制剂及其应用 |
| CN102940652B (zh) | 2008-05-28 | 2015-03-25 | 青岛东海药业有限公司 | 两形真杆菌制剂及其应用 |
| WO2009149149A1 (en) | 2008-06-04 | 2009-12-10 | Trustees Of Dartmouth College | Prevention or treatment of immune-relevant disease by modification of microfloral populations |
| EP2133088A3 (en) | 2008-06-09 | 2010-01-27 | Nestec S.A. | Rooibos and inflammation |
| WO2009151315A1 (en) | 2008-06-13 | 2009-12-17 | N.V. Nutricia | Nutritional composition for infants delivered via caesarean section |
| WO2009154463A2 (en) | 2008-06-20 | 2009-12-23 | Stichting Top Institute Food And Nutrition | Butyrate as a medicament to improve visceral perception in humans |
| EP2138186A1 (en) | 2008-06-24 | 2009-12-30 | Nestec S.A. | Probiotics, secretory IgA and inflammation |
| WO2010002241A1 (en) | 2008-06-30 | 2010-01-07 | N.V. Nutricia | Nutritional composition for infants delivered via caesarean section |
| KR101017448B1 (ko) | 2008-09-18 | 2011-02-23 | 주식회사한국야쿠르트 | 대장의 건강 증진 효능을 갖는 비피도박테리움 롱검 에이취와이8004 및 이를 유효성분으로 함유하는 제품 |
| US8137718B2 (en) | 2008-09-19 | 2012-03-20 | Mead Johnson Nutrition Company | Probiotic infant products |
| US20100074870A1 (en) | 2008-09-19 | 2010-03-25 | Bristol-Myers Squibb Company | Probiotic infant products |
| KR101057357B1 (ko) | 2008-09-22 | 2011-08-17 | 광주과학기술원 | 유산균 및 콜라겐을 유효성분으로 포함하는 관절염 예방 또는 치료용 약제학적 조성물 및 식품 조성물 |
| US9603876B2 (en) | 2008-09-25 | 2017-03-28 | New York University | Compositions and methods for restoring gastrointestinal microbiota following antibiotic treatment |
| WO2010037408A1 (en) | 2008-09-30 | 2010-04-08 | Curevac Gmbh | Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof |
| WO2010037402A1 (en) | 2008-10-02 | 2010-04-08 | Dako Denmark A/S | Molecular vaccines for infectious disease |
| US20110223137A1 (en) | 2008-12-05 | 2011-09-15 | Nestec S.A. | Compositions for use in low-birth weight infants |
| CA2746805A1 (en) | 2008-12-19 | 2010-06-24 | Nestec S.A. | Prevention and treatment of rotavirus diarrhoea |
| IT1392672B1 (it) | 2009-01-12 | 2012-03-16 | Wyeth Consumer Healthcare S P A | Composizioni comprendenti componenti probiotici e prebiotici e sali minerali, con lactoferrina |
| BRPI1013688A8 (pt) | 2009-03-05 | 2017-02-14 | Abbott Lab | Proteínas de ligação de il-17. |
| JP5710876B2 (ja) | 2009-03-26 | 2015-04-30 | クロスフィールドバイオ株式会社 | 新規ビフィドバクテリウム属微生物およびその利用 |
| US8816067B2 (en) | 2009-05-07 | 2014-08-26 | Tate & Lyle Ingredients France SAS | Compositions and methods for making alpha-(1,2)-branched alpha-(1,6) oligodextrans |
| EP2251022A1 (en) | 2009-05-11 | 2010-11-17 | Nestec S.A. | Non-replicating micro-organisms and their immune boosting effect |
| CA2761444C (en) | 2009-05-11 | 2018-04-24 | Nestec S.A. | Lactobacillus johnsonii la1 ncc533 (cncm i-1225) and immune disorders |
| EP2251020A1 (en) | 2009-05-11 | 2010-11-17 | Nestec S.A. | Short-time high temperature treatment generates microbial preparations with anti-inflammatory profiles |
| KR20100128168A (ko) | 2009-05-27 | 2010-12-07 | 중앙대학교 산학협력단 | 공액 리놀레산 생산능이 우수한 신규한 균주 |
| US20100311686A1 (en) | 2009-06-03 | 2010-12-09 | Kasper Lloyd H | Nutraceutical composition and methods for preventing or treating multiple sclerosis |
| WO2010143940A1 (en) | 2009-06-12 | 2010-12-16 | N.V. Nutricia | Synergistic mixture of beta-galacto-oligosaccharides with beta-1,3 and beta-1,4/1,6 linkages |
| EP2443259A4 (en) | 2009-06-16 | 2012-10-10 | Univ Columbia | BIOMARKERS FOR AUTISM AND USES THEREOF |
| WO2011005756A1 (en) | 2009-07-06 | 2011-01-13 | Puretech Ventures, Llc | Delivery of agents targeted to microbiota niches |
| WO2011011094A1 (en) | 2009-07-24 | 2011-01-27 | Dowd Scot E | Universal microbial diagnosis, detection, quantification, and specimen-targeted therapy |
| CA2770062A1 (en) | 2009-08-18 | 2011-02-24 | Nestec S.A. | A nutritional composition comprising bifidobacterium longum strains and reducing food allergy symptoms, especially in infants and children |
| US20110053829A1 (en) | 2009-09-03 | 2011-03-03 | Curevac Gmbh | Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids |
| CA2775050C (en) | 2009-09-23 | 2020-07-14 | Thomas Julius Borody | Therapy for enteric infections |
| EP2308498A1 (en) | 2009-09-30 | 2011-04-13 | Nestec S.A. | Administration of Bifidobacterium breve during infancy to prevent inflammation later in life |
| EP2486143A1 (en) | 2009-10-05 | 2012-08-15 | AAK Patent B.V. | Methods for diagnosing irritable bowel syndrome |
| EP3144004A1 (en) | 2009-10-06 | 2017-03-22 | Scott Dorfner | Antibiotic formulations providing reduced gastrointestinal side effects and clostridium difficile infection relapse, and related methods |
| CN102946891B (zh) | 2009-11-11 | 2017-09-01 | 营养健康有限公司 | 益生菌双歧杆菌菌株 |
| US10212954B2 (en) | 2009-12-18 | 2019-02-26 | Colgate-Palmolive Company | Pet food compositions including probiotics and methods of manufacture and use thereof |
| US20150104418A1 (en) | 2014-12-18 | 2015-04-16 | Microbios, Inc. | Bacterial composition |
| FR2955774A1 (fr) | 2010-02-02 | 2011-08-05 | Aragan | Preparation destinee a traiter l'exces ponderal et les desordres associes et applications de ladite preparation |
| NL2004201C2 (en) | 2010-02-05 | 2011-08-08 | Friesland Brands Bv | Use of sialyl oligosaccharides to modulate the immune system. |
| NL2004200C2 (en) | 2010-02-05 | 2011-08-08 | Friesland Brands Bv | Use of sialyl oligosaccharides in weight management. |
| IT1398553B1 (it) | 2010-03-08 | 2013-03-01 | Probiotical Spa | Composizione comprendente batteri probiotici per il trattamento di patologie associate con le alterazioni del sistema immunitario. |
| JP5737646B2 (ja) | 2010-03-24 | 2015-06-17 | 森下仁丹株式会社 | 抗アレルギー剤 |
| EP2552464B1 (en) | 2010-03-30 | 2018-02-28 | Assistance Publique - Hôpitaux de Paris | Use of bifidobacteria for preventing allergy in breastfed infants |
| US8951512B2 (en) | 2010-05-04 | 2015-02-10 | New York University | Methods for treating bone disorders by characterizing and restoring mammalian bacterial microbiota |
| WO2011149335A1 (en) | 2010-05-25 | 2011-12-01 | N.V. Nutricia | Immune imprinting nutritional composition |
| CA2836413A1 (en) | 2010-06-01 | 2011-12-08 | Moore Research Enterprises Llc | Cellular constituents from bacteroides, compositions thereof, and therapeutic methods employing bacteroides or cellular constituents thereof |
| WO2011151941A1 (ja) | 2010-06-04 | 2011-12-08 | 国立大学法人東京大学 | 制御性ｔ細胞の増殖または集積を誘導する作用を有する組成物 |
| TWI417054B (zh) | 2010-06-15 | 2013-12-01 | Jen Shine Biotechnology Co Ltd | 新穎糞腸球菌ｌｊｓ－０１及其益生用途 |
| EP2397145A1 (en) | 2010-06-18 | 2011-12-21 | Nestec S.A. | L. johnsonii La1, B. longum NCC2705 and immune disorders |
| FR2962045B1 (fr) | 2010-07-05 | 2012-08-17 | Bifinove | Complexe macromoleculaire d'origine bacterienne et utilisation dudit complexe moleculaire pour prevenir et traiter les rhumatismes inflammatoires |
| TWI401086B (zh) | 2010-07-20 | 2013-07-11 | Univ China Medical | 胚芽乳酸桿菌及其用途 |
| KR102157718B1 (ko) | 2010-07-26 | 2020-09-18 | 큐 바이올로직스 인코포레이티드 | 면역원성 소염 조성물 |
| CA2807242C (en) | 2010-08-04 | 2017-05-02 | Thomas Julius Borody | Compositions for fecal floral transplantation and methods for making and using them and devices for delivering them |
| US9386793B2 (en) | 2010-08-20 | 2016-07-12 | New York University | Compositions and methods for treating obesity and related disorders by characterizing and restoring mammalian bacterial microbiota |
| KR101250463B1 (ko) | 2010-10-12 | 2013-04-15 | 대한민국 | 신생아 분변에서 분리한 내산소성 비피도박테리움 롱검 비피더스 유산균 및 이를 이용한 프로바이오틱 조성물 |
| WO2012055408A1 (en) | 2010-10-27 | 2012-05-03 | Quantibact A/S | Capture of target dna and rna by probes comprising intercalator molecules |
| CN102031235B (zh) | 2010-11-09 | 2012-07-25 | 中国农业大学 | 一种粪肠球菌anse228及其应用 |
| EP2455092A1 (en) | 2010-11-11 | 2012-05-23 | Nestec S.A. | Non-replicating probiotic micro-organisms protect against upper respiratory tract infections |
| US20120128644A1 (en) | 2010-11-24 | 2012-05-24 | Oragenics, Inc. | Use of Bacteria to Treat and Prevent Respiratory Infections |
| CN102093967B (zh) | 2010-12-02 | 2013-01-30 | 中国农业科学院特产研究所 | 一株水貂源屎肠球菌及其应用 |
| ES2389547B1 (es) | 2010-12-07 | 2013-08-08 | Consejo Superior De Investigaciones Científicas (Csic) | Bifidobacterium cect 7765 y su uso en la prevención y/o tratamiento del sobrepeso, la obesidad y patologías asociadas. |
| MX361355B (es) | 2011-01-10 | 2018-12-04 | Cleveland Biolabs Inc | Uso del agonista del receptor tipo toll para el tratamiento del cáncer. |
| EP2481299B1 (en) | 2011-01-31 | 2016-12-07 | Dr. Fischer Gesundheitsprodukte GmbH | Bifidobacterium bifidum strains for application in gastrointestinal diseases |
| JP5840368B2 (ja) | 2011-02-02 | 2016-01-06 | カルピス株式会社 | 関節炎予防改善用物質 |
| WO2012108830A1 (en) | 2011-02-09 | 2012-08-16 | Lavivo Ab | Synbiotic compositions for restoration and reconstitution of gut microbiota |
| US9968638B2 (en) | 2011-03-09 | 2018-05-15 | Regents Of The University Of Minnesota | Compositions and methods for transplantation of colon microbiota |
| BRPI1100857A2 (pt) | 2011-03-18 | 2013-05-21 | Alexandre Eduardo Nowill | agente imunomodulador e suas combinaÇÕes, seu uso e mÉtodo imunoterÁpico para a recontextualizaÇço, reprogramaÇço e reconduÇço do sistema imune em tempo real |
| WO2012140636A1 (en) | 2011-04-11 | 2012-10-18 | Alimentary Health Limited | A probiotic formulation |
| WO2012142605A1 (en) | 2011-04-15 | 2012-10-18 | Samaritan Health Services | Rapid recolonization deployment agent |
| SG194542A1 (en) | 2011-04-20 | 2013-12-30 | Mico Bio Inc | Composition and method for enhancing an immune response |
| US9567361B2 (en) | 2011-05-13 | 2017-02-14 | Glycosyn LLC | Use of purified 2′-fucosyllactose, 3-fucosyllactose and lactodifucotetraose as prebiotics |
| KR20120133133A (ko) | 2011-05-30 | 2012-12-10 | 한국 한의학 연구원 | 생약 추출물 또는 이의 유산균 발효물을 포함하는 호흡기 질환의 예방 또는 치료용 조성물 |
| WO2012170478A2 (en) | 2011-06-06 | 2012-12-13 | The University Of North Carolina At Chapel Hill | Methods and kits for detecting adenomas, colorectal cancer, and uses thereof |
| GB201110095D0 (en) | 2011-06-15 | 2011-07-27 | Danisco | Method of treatment |
| JP2013005759A (ja) | 2011-06-24 | 2013-01-10 | Kyodo Milk Industry Co Ltd | マウス腸内菌叢の推測方法 |
| WO2013005836A1 (ja) | 2011-07-07 | 2013-01-10 | 長岡香料株式会社 | フルクトース吸収阻害剤 |
| WO2013008102A2 (en) | 2011-07-14 | 2013-01-17 | R.E.D. Laboratories N.V../ S.A. | Methods and compositions for evaluating and/or treating chronic immune diseases |
| GB201112091D0 (en) * | 2011-07-14 | 2011-08-31 | Gt Biolog Ltd | Bacterial strains isolated from pigs |
| US20130022575A1 (en) | 2011-07-19 | 2013-01-24 | Microbial Rx | Systems and methods of replacing intestinal flora |
| CN102304483A (zh) | 2011-08-12 | 2012-01-04 | 北京金泰得生物科技股份有限公司 | 一株饲用屎肠球菌及其应用 |
| KR101261872B1 (ko) | 2011-08-23 | 2013-05-14 | 대한민국 (식품의약품안전처장) | 장내 미생물 효소복합체 및 이의 제조방법 |
| US20140363397A1 (en) | 2011-09-14 | 2014-12-11 | Queen's University At Kingston | Method for treatment of disorders of the gastrointestinal system |
| GB201117313D0 (en) | 2011-10-07 | 2011-11-16 | Gt Biolog Ltd | Bacterium for use in medicine |
| WO2013053836A1 (en) | 2011-10-11 | 2013-04-18 | Quantum Pharmaceuticals Sa | Composition comprising anaerobically cultivated human intestinal microbiota |
| CN103082292B (zh) | 2011-11-02 | 2015-03-04 | 深圳华大基因研究院 | 罗斯氏菌(Roseburia)在治疗和预防肥胖相关疾病中的应用 |
| CN102373172B (zh) | 2011-11-03 | 2013-03-20 | 北京龙科方舟生物工程技术有限公司 | 一株屎肠球菌及其应用 |
| CN108676774B (zh) | 2011-12-01 | 2023-05-09 | 国立大学法人东京大学 | 诱导调节性t细胞的增殖或积累的人源细菌 |
| ES2408279B1 (es) | 2011-12-15 | 2014-09-09 | Universidad De Las Palmas De Gran Canaria | Bacteria acido láctica probiótica |
| ITBG20120010A1 (it) | 2012-02-24 | 2013-08-25 | Milano Politecnico | Dispositivo per l'addestramento chirurgico |
| ITMI20120471A1 (it) | 2012-03-26 | 2013-09-27 | Giovanni Mogna | Composizione a base di ceppi di batteri bifidobacterium longum in grado di aiutare il prolungamento della vita |
| JP5792105B2 (ja) | 2012-03-27 | 2015-10-07 | 森永乳業株式会社 | ラクト−ｎ−ビオースｉの製造方法 |
| JP6201982B2 (ja) | 2012-03-30 | 2017-09-27 | 味の素株式会社 | 糖尿病誘起細菌 |
| US20130280724A1 (en) | 2012-04-11 | 2013-10-24 | Nestec Sa | Methods for diagnosing impending diarrhea |
| GB201206599D0 (en) | 2012-04-13 | 2012-05-30 | Univ Manchester | Probiotic bacteria |
| CN104507483A (zh) | 2012-04-13 | 2015-04-08 | 波士顿学院理事会 | 益生元组合物及使用方法 |
| ES2792106T3 (es) | 2012-05-18 | 2020-11-10 | Genome Res Ltd | Métodos y grupos |
| ES2436251B1 (es) | 2012-05-25 | 2014-10-08 | Consejo Superior De Investigaciones Científicas (Csic) | Bacteroides cect 7771 y su uso en la prevención y tratamiento de sobrepeso, obesidad y alteraciones metabólicas e inmunológicas. |
| WO2013181694A1 (en) | 2012-06-04 | 2013-12-12 | Gaurav Agrawal | Compositions and methods for treating crohn's disease and related conditions and infections |
| CN106620189B (zh) | 2012-06-06 | 2021-11-19 | 上海交通大学 | 改善肠道菌群结构的方法及应用 |
| US9676847B2 (en) | 2012-06-25 | 2017-06-13 | Orega Biotech | IL-17 antagonist antibodies |
| BR112015001884B1 (pt) | 2012-07-31 | 2020-12-01 | Société des Produits Nestlé S.A. | composição nutricional para promover a saúde musculoesquelética em pacientes com doença inflamatória intestinal (ibd), seu uso, e formulação farmacêutica, formulação nutricional, formulação de alimentação por tubo, suplemento alimentar, alimento funcional ou produto de bebida |
| US20150211053A1 (en) | 2012-08-01 | 2015-07-30 | Bgi-Shenzhen | Biomarkers for diabetes and usages thereof |
| WO2014036182A2 (en) | 2012-08-29 | 2014-03-06 | California Institute Of Technology | Diagnosis and treatment of autism spectrum disorder |
| JP2015531770A (ja) | 2012-08-29 | 2015-11-05 | サリックス ファーマシューティカルズ，インコーポレイテッド | 緩下剤組成物、ならびに便秘および関連胃腸疾患および症状を処置するための方法 |
| EP2894985A4 (en) | 2012-09-13 | 2016-09-28 | Massachusetts Inst Technology | PROGRAMMABLE ACTIVE COMPOUND PROFILES OF TUMORED BACTERIA |
| KR101473058B1 (ko) | 2012-09-19 | 2014-12-16 | 주식회사 쎌바이오텍 | 과민성 대장 증후군 예방 또는 치료용 조성물 |
| CN103652322B (zh) | 2012-09-21 | 2016-02-10 | 临沂思科生物科技有限公司 | 一种含乳酸菌的复合益生菌饲料添加剂的制备方法 |
| WO2014053608A1 (en) | 2012-10-03 | 2014-04-10 | Metabogen Ab | Identification of a person having risk for atherosclerosis and associated diseases by the person's gut microbiome and the prevention of such diseases |
| FR2997091B1 (fr) | 2012-10-22 | 2016-05-06 | Fond Mediterranee Infection | Utilisation d'un compose antioxydant pour la culture de bacteries sensibles a la tension en oxygene |
| US9839657B2 (en) | 2012-10-30 | 2017-12-12 | Deerland Enzymes, Inc. | Prebiotic compositions comprising one or more types of bacteriophage |
| WO2014067976A1 (en) | 2012-10-30 | 2014-05-08 | Nestec S.A. | Compositions comprising microparticles and probiotics to deliver a synergistic immune effect |
| JP2015535280A (ja) | 2012-11-01 | 2015-12-10 | レイクスユニフェルシテイト フローニンゲン | 胃腸管において有益な細菌を刺激する方法及び組成物 |
| WO2014075745A1 (en) | 2012-11-19 | 2014-05-22 | Université Catholique de Louvain | Use of akkermansia for treating metabolic disorders |
| US8906668B2 (en) | 2012-11-23 | 2014-12-09 | Seres Health, Inc. | Synergistic bacterial compositions and methods of production and use thereof |
| KR102617655B1 (ko) | 2012-11-23 | 2023-12-27 | 세레스 테라퓨틱스, 인코포레이티드 | 상승작용적 박테리아 조성물, 그리고 이의 제조 방법 및 용도 |
| JP2016501852A (ja) | 2012-11-26 | 2016-01-21 | トーマス・ジュリアス・ボロディ | 糞便微生物叢の回復のための組成物、ならびにそれらを作製および使用する方法 |
| WO2014093655A2 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains |
| DK3064585T3 (da) | 2012-12-12 | 2020-04-27 | Broad Inst Inc | Konstruering og optimering af forbedrede systemer, fremgangsmåder og enzymsammensætninger til sekvensmanipulation |
| SG11201504523UA (en) | 2012-12-12 | 2015-07-30 | Broad Inst Inc | Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications |
| US20140193464A1 (en) | 2013-01-08 | 2014-07-10 | Imagilin Technology, Llc | Effects of probiotics on humans and animals under environmental or biological changes |
| KR20230110367A (ko) | 2013-02-04 | 2023-07-21 | 세레스 테라퓨틱스, 인코포레이티드 | 조성물 및 방법 |
| EP2951283A4 (en) | 2013-02-04 | 2017-01-25 | Seres Therapeutics, Inc. | Compositions and methods |
| EP3536328B1 (en) | 2013-02-22 | 2021-10-27 | The Regents of The University of California | Food or beverage product, or probiotic composition, comprising lactobacillus johnsonii 456 |
| CN105228635A (zh) | 2013-03-05 | 2016-01-06 | 格罗宁根大学 | Faecalibacterium prausnitzii HTF-F（DSM 26943）在抑制炎症中的应用 |
| NZ711298A (en) | 2013-03-14 | 2021-07-30 | Therabiome Llc | Targeted gastrointestinal tract delivery of probiotic organisms and/or therapeutic agents |
| WO2014153194A2 (en) | 2013-03-14 | 2014-09-25 | Seres Health, Inc. | Methods for pathogen detection and enrichment from materials and compositions |
| EP2967077A4 (en) | 2013-03-15 | 2016-09-14 | Seres Therapeutics Inc | MICROBIAL COMPOSITIONS AND ASSOCIATED METHODS BASED ON A NETWORK |
| US9669059B2 (en) | 2013-03-15 | 2017-06-06 | University Of Florida Research Foundation, Incorporated | Butyrogenic bacteria as probiotics to treat clostridium difficile |
| CN103142656A (zh) | 2013-03-18 | 2013-06-12 | 广州知光生物科技有限公司 | 脆弱拟杆菌在制备防治结肠癌组合物中的应用 |
| CN103156888A (zh) | 2013-03-18 | 2013-06-19 | 广州知光生物科技有限公司 | 脆弱拟杆菌在制备治疗炎症性肠病组合物中的应用 |
| CN103146620A (zh) | 2013-03-25 | 2013-06-12 | 广州知光生物科技有限公司 | 具有益生菌特性的脆弱拟杆菌 |
| JP2014196260A (ja) | 2013-03-29 | 2014-10-16 | 公立大学法人奈良県立医科大学 | 慢性閉塞性肺疾患の予防又は治療用組成物 |
| GB201306536D0 (en) * | 2013-04-10 | 2013-05-22 | Gt Biolog Ltd | Polypeptide and immune modulation |
| JP2016521284A (ja) | 2013-05-10 | 2016-07-21 | カリフォルニア インスティチュート オブ テクノロジー | 大腸ガンのプロバイオティクスによる防止および処置 |
| US9511099B2 (en) | 2013-06-05 | 2016-12-06 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| JP6330032B2 (ja) | 2013-06-05 | 2018-05-23 | レビオティクス インコーポレイテッドＲｅｂｉｏｔｉｘ，Ｉｎｃ． | 微生物叢回復療法組成物を製造、処理、および梱包するための方法 |
| WO2014201037A2 (en) | 2013-06-10 | 2014-12-18 | New York University | Methods for manipulating immune responses by altering microbiota |
| WO2014200334A1 (en) | 2013-06-14 | 2014-12-18 | N.V. Nutricia | Synbiotic composition for treatment of infections in allergic patients |
| WO2015003001A1 (en) | 2013-07-01 | 2015-01-08 | The Washington University | Methods for identifying supplements that increase gut colonization by an isolated bacterial species, and compositions derived therefrom |
| WO2015006355A2 (en) | 2013-07-09 | 2015-01-15 | Puretech Ventures, Llc | Compositions containing combinations of bioactive molecules derived from microbiota for treatment of disease |
| US10633714B2 (en) | 2013-07-21 | 2020-04-28 | Pendulum Therapeutics, Inc. | Methods and systems for microbiome characterization, monitoring and treatment |
| WO2015017625A1 (en) | 2013-07-31 | 2015-02-05 | Wikifoods, Inc. | Encapsulated functional food compositions |
| EP3033091B1 (en) | 2013-08-16 | 2022-09-07 | Versitech Limited | Probiotic composition and use thereof in the prevention and treatment of hepatocellular carcinoma |
| CN103509741B (zh) | 2013-08-22 | 2015-02-18 | 河北农业大学 | 布劳特菌auh-jld56及其在牛蒡苷元转化中的应用 |
| ITMI20131467A1 (it) | 2013-09-06 | 2015-03-07 | Sofar Spa | Uso di una composizione comprendente microrganismi per aumentare la produzione intestinale di acido butirrico, di acido folico o di niacina e/o per diminuire la produzione intestinale di acido succinico |
| US10203329B2 (en) | 2013-09-12 | 2019-02-12 | The Johns Hopkins University | Biofilm formation to define risk for colon cancer |
| PL3071052T3 (pl) | 2013-10-18 | 2020-07-27 | Innovachildfood Ab | Zbilansowany pod względem odżywczym złożony posiłek dla niemowląt i małych dzieci oraz sposób otrzymywania wspomnianego posiłku |
| PL229020B1 (pl) | 2013-11-13 | 2018-05-30 | Inst Biotechnologii Surowic I Szczepionek Biomed Spolka Akcyjna | Nowy szczep Bifidobacterium breve |
| US10258655B2 (en) | 2013-11-25 | 2019-04-16 | Seres Therapeutics, Inc. | Synergistic bacterial compositions and methods of production and use thereof |
| WO2015095241A2 (en) | 2013-12-16 | 2015-06-25 | Seres Health, Inc. | Bacterial compositions and methods of use thereof for treatment of immune system disorders |
| CN103981117B (zh) | 2013-12-24 | 2018-10-26 | 北京大伟嘉生物技术股份有限公司 | 一株高抗逆性屎肠球菌及其培养方法和应用 |
| CN103981115B (zh) | 2013-12-24 | 2018-10-26 | 北京大伟嘉生物技术股份有限公司 | 一株高抗逆性屎肠球菌及其应用 |
| CN103820363B (zh) | 2014-01-27 | 2016-02-24 | 福建省农业科学院生物技术研究所 | 一种屎肠球菌菌粉的制备与应用 |
| CN103865846B (zh) | 2014-02-27 | 2016-03-30 | 扬州绿保生物科技有限公司 | 一种屎肠球菌及其制备方法 |
| CN103849590B (zh) | 2014-03-25 | 2016-07-06 | 上海交通大学 | 一株耐酸短双歧杆菌BB8dpH及其应用 |
| KR101683474B1 (ko) | 2014-03-26 | 2016-12-08 | 주식회사 쎌바이오텍 | 과민성 대장 증후군 예방 또는 치료용 조성물 |
| US9783858B2 (en) | 2014-04-02 | 2017-10-10 | Northwestern University | Altered microbiome of chronic pelvic pain |
| KR101583546B1 (ko) | 2014-04-09 | 2016-01-11 | 국립암센터 | 유전자 다형성을 이용한 소라페닙 치료에 대한 반응성 예측방법 |
| CN106659746A (zh) | 2014-04-10 | 2017-05-10 | 国立研究开发法人理化学研究所 | 用于诱导th17细胞的组合物及方法 |
| CN104195075B (zh) | 2014-08-14 | 2017-04-19 | 生合生物科技股份有限公司 | 一种屎肠球菌ef08及包含它的饲料添加物和饲料 |
| WO2015168534A1 (en) | 2014-05-02 | 2015-11-05 | Novogy, Inc. | Therapeutic treatment of gastrointestinal microbial imbalances through competitive microbe displacement |
| SG11201608835VA (en) | 2014-05-08 | 2016-11-29 | Panoptes Pharma Ges M B H | Compounds for treating ophthalmic diseases and disorders |
| CN106687130B (zh) | 2014-08-05 | 2020-01-21 | 深圳华大基因科技有限公司 | 真杆菌属在预防和治疗结直肠癌相关疾病中的用途 |
| CN106573044B (zh) | 2014-08-05 | 2020-01-21 | 深圳华大基因科技有限公司 | 真杆菌属在预防和治疗结直肠癌相关疾病中的用途 |
| WO2016033439A2 (en) | 2014-08-28 | 2016-03-03 | Yale University | Compositions and methods for the treating an inflammatory disease or disorder |
| US20160058808A1 (en) | 2014-09-03 | 2016-03-03 | California Institute Of Technology | Microbe-based modulation of serotonin biosynthesis |
| CN104546933A (zh) | 2014-09-30 | 2015-04-29 | 深圳华大基因科技有限公司 | 粪拟杆菌在治疗或预防类风湿性关节炎或其相关疾病中的应用 |
| CN104546934B (zh) | 2014-09-30 | 2019-04-09 | 深圳华大基因科技有限公司 | 粪副拟杆菌在治疗或预防类风湿性关节炎或其相关疾病中的应用 |
| CN104546940A (zh) | 2014-09-30 | 2015-04-29 | 深圳华大基因科技有限公司 | 平常拟杆菌在治疗或预防类风湿性关节炎或其相关疾病中的应用 |
| CN104546942A (zh) | 2014-09-30 | 2015-04-29 | 深圳华大基因科技有限公司 | 多氏拟杆菌在治疗或预防类风湿性关节炎或其相关疾病中的应用 |
| CN104546932A (zh) | 2014-09-30 | 2015-04-29 | 深圳华大基因科技有限公司 | 卵形拟杆菌在治疗或预防类风湿性关节炎或其相关疾病中的应用 |
| CN104546935A (zh) | 2014-09-30 | 2015-04-29 | 深圳华大基因科技有限公司 | 多形拟杆菌在治疗或预防类风湿性关节炎或其相关疾病中的应用 |
| WO2016057671A1 (en) | 2014-10-07 | 2016-04-14 | University Of Virginia Patent Foundation | Compositions and methods for preventing and treating infection |
| CA2965663C (en) | 2014-10-24 | 2023-04-04 | Evolve Biosystems, Inc. | Activated bifidobacteria and methods of use thereof |
| CN107106616A (zh) | 2014-10-30 | 2017-08-29 | 加利福尼亚技术学院 | 包括改善神经发育障碍行为的细菌的组合物和方法 |
| JP6800846B2 (ja) | 2014-10-30 | 2020-12-16 | カリフォルニア インスティチュート オブ テクノロジー | 神経発達症群における行動の改善のための細菌含有組成物、及び細菌を使用することを含む、神経発達症群における行動の改善のための方法 |
| EP3881680A1 (en) | 2014-10-31 | 2021-09-22 | Pendulum Therapeutics, Inc. | Methods and compositions relating to microbial treatment |
| CN104435000A (zh) | 2014-11-12 | 2015-03-25 | 江南大学 | 乳酸菌对支气管哮喘治疗中的应用 |
| CN107249609A (zh) | 2014-11-25 | 2017-10-13 | 纪念斯隆-凯特琳癌症中心 | 肠道微生物群和gvhd |
| MA41020A (fr) | 2014-11-25 | 2017-10-03 | Evelo Biosciences Inc | Compositions probiotiques et prébiotiques, et leurs procédés d'utilisation pour la modulation du microbiome |
| WO2016102951A1 (en) | 2014-12-23 | 2016-06-30 | 4D Pharma Research Limited | Pirin polypeptide and immune modulation |
| ME02997B (me) | 2014-12-23 | 2018-10-20 | 4D Pharma Res Ltd | Soj bacteroides thetaiotaomicron i njegova upotreba u smanjenju inflamacije |
| CN104560820B (zh) | 2014-12-30 | 2017-10-20 | 杭州师范大学 | 屎肠球菌kq2.6及应用 |
| KR20170128247A (ko) | 2015-01-23 | 2017-11-22 | 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | 암 예방에서 단쇄 지방산의 용도 |
| CN105982919A (zh) | 2015-02-26 | 2016-10-05 | 王汉成 | 生物减速剂抗癌技术 |
| WO2016139217A1 (en) | 2015-03-04 | 2016-09-09 | Ab-Biotics, S.A. | Composition comprising anaerobically cultivated human intestinal microbiota |
| US20180078587A1 (en) | 2015-03-18 | 2018-03-22 | Trustees Of Tufts College | Compositions and methods for preventing colorectal cancer |
| EP3270938A4 (en) | 2015-03-18 | 2018-12-19 | Whole Biome Inc. | Methods and compositions relating to microbial treatment and diagnosis of skin disorders |
| JP2018521013A (ja) | 2015-06-01 | 2018-08-02 | ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ | 共生微生物叢の操作による癌の処置 |
| MD3307288T2 (ro) | 2015-06-15 | 2019-12-31 | 4D Pharma Res Ltd | Compoziții care conțin tulpini bacteriene |
| PL3206700T3 (pl) | 2015-06-15 | 2019-11-29 | 4D Pharma Res Ltd | Kompozycje zawierające szczepy bakteryjne |
| MA41060B1 (fr) | 2015-06-15 | 2019-11-29 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| CN115364122A (zh) | 2015-06-15 | 2022-11-22 | 4D制药研究有限公司 | 包含细菌菌株的组合物 |
| MA41010B1 (fr) | 2015-06-15 | 2020-01-31 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| CN105112333A (zh) | 2015-08-31 | 2015-12-02 | 江南大学 | 一种具有良好肠道定殖能力的长双歧杆菌及筛选方法和应用 |
| EP3370748B1 (en) | 2015-11-03 | 2022-06-08 | The Brigham and Women's Hospital, Inc. | Therapeutic microbiota for the treatment and/or prevention of food allergy |
| GB201520497D0 (en) | 2015-11-20 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| EA034677B1 (ru) | 2015-11-20 | 2020-03-05 | 4Д Фарма Рисёрч Лимитед | Композиции для лечения или профилактики рака, содержащие штамм enterococcus gallinarum |
| GB201520631D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| GB201520638D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| WO2017091753A1 (en) | 2015-11-25 | 2017-06-01 | Memorial Sloan-Kettering Cancer Center | Methods and compositions for reducing vancomycin-resistant enterococci infection or colonization |
| DK3313423T3 (da) | 2016-03-04 | 2019-05-20 | 4D Pharma Plc | Sammensætninger omfattende bakterielle blautia-stammer til behandling af visceral hypersensitivitet |
| AU2017234120B2 (en) | 2016-03-14 | 2024-06-20 | Holobiome, Inc. | Modulation of the gut microbiome to treat mental disorders or diseases of the central nervous system |
| TWI802545B (zh) | 2016-07-13 | 2023-05-21 | 英商４Ｄ製藥有限公司 | 包含細菌菌株之組合物 |
| IT201600091033A1 (it) | 2016-09-08 | 2018-03-08 | Bioimmunizer Sagl | Ceppi di batteri probiotici appartenenti al genere Bifidobacterium e loro estratti di cellule probiotiche (ECP) aventi proprietà immunostimolanti. |
| GB201621123D0 (en) | 2016-12-12 | 2017-01-25 | 4D Pharma Plc | Compositions comprising bacterial strains |
| WO2018112363A1 (en) | 2016-12-16 | 2018-06-21 | Evelo Biosciences, Inc. | Methods of treating cancer using parabacteroides |
| WO2018112365A2 (en) | 2016-12-16 | 2018-06-21 | Evelo Biosciences, Inc. | Methods of treating colorectal cancer and melanoma using parabacteroides goldsteinii |
| WO2018215782A1 (en) | 2017-05-24 | 2018-11-29 | 4D Pharma Research Limited | Compositions comprising bacterial strain |
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