NO331027B1 - Forbindelse som bindes til en mpl-reseptor, dimer, polynukleotid, vektor, vertscelle, fremgangsmate for fremstilling av en forbindelse, anvendelse av en forbindelse for fremstilling av et medikament, samt farmasoytisk preparat. - Google Patents

Forbindelse som bindes til en mpl-reseptor, dimer, polynukleotid, vektor, vertscelle, fremgangsmate for fremstilling av en forbindelse, anvendelse av en forbindelse for fremstilling av et medikament, samt farmasoytisk preparat.

Info

Publication number
NO331027B1
NO331027B1 NO20011962A NO20011962A NO331027B1 NO 331027 B1 NO331027 B1 NO 331027B1 NO 20011962 A NO20011962 A NO 20011962A NO 20011962 A NO20011962 A NO 20011962A NO 331027 B1 NO331027 B1 NO 331027B1
Authority
NO
Norway
Prior art keywords
compound
preparation
dimer
polynucleotide
binds
Prior art date
Application number
NO20011962A
Other languages
English (en)
Norwegian (no)
Other versions
NO20011962L (no
NO20011962D0 (no
Inventor
Chuan-Fa Liu
Ulrich Feige
Janet Cheetham
Original Assignee
Kirin Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kirin Amgen Inc filed Critical Kirin Amgen Inc
Publication of NO20011962D0 publication Critical patent/NO20011962D0/no
Publication of NO20011962L publication Critical patent/NO20011962L/no
Publication of NO331027B1 publication Critical patent/NO331027B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
NO20011962A 1998-10-23 2001-04-20 Forbindelse som bindes til en mpl-reseptor, dimer, polynukleotid, vektor, vertscelle, fremgangsmate for fremstilling av en forbindelse, anvendelse av en forbindelse for fremstilling av et medikament, samt farmasoytisk preparat. NO331027B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10534898P 1998-10-23 1998-10-23
PCT/US1999/024834 WO2000024770A2 (en) 1998-10-23 1999-10-22 Dimeric thrombopoietin peptide mimetics binding to mp1 receptor and having thrombopoietic activity

Publications (3)

Publication Number Publication Date
NO20011962D0 NO20011962D0 (no) 2001-04-20
NO20011962L NO20011962L (no) 2001-06-21
NO331027B1 true NO331027B1 (no) 2011-09-12

Family

ID=22305310

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20011962A NO331027B1 (no) 1998-10-23 2001-04-20 Forbindelse som bindes til en mpl-reseptor, dimer, polynukleotid, vektor, vertscelle, fremgangsmate for fremstilling av en forbindelse, anvendelse av en forbindelse for fremstilling av et medikament, samt farmasoytisk preparat.
NO2012005C NO2012005I2 (no) 1998-10-23 2012-03-12 Romiplostim

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO2012005C NO2012005I2 (no) 1998-10-23 2012-03-12 Romiplostim

Country Status (36)

Country Link
US (8) US6835809B1 (de)
EP (3) EP2319928B9 (de)
JP (2) JP3820105B2 (de)
KR (1) KR100719202B1 (de)
CN (2) CN1810832B (de)
AR (1) AR020934A1 (de)
AT (1) ATE348163T1 (de)
AU (1) AU773891C (de)
BG (3) BG110221A (de)
BR (1) BRPI9914698B8 (de)
CA (1) CA2346996C (de)
CY (4) CY1107526T1 (de)
CZ (1) CZ302155B6 (de)
DE (2) DE122009000039I1 (de)
DK (3) DK1124961T3 (de)
EA (1) EA003998B1 (de)
ES (3) ES2388341T3 (de)
FR (1) FR09C0030I2 (de)
HK (2) HK1042114B (de)
HU (1) HU228582B1 (de)
IL (1) IL142023A0 (de)
LT (1) LTC1124961I2 (de)
LU (1) LU91598I2 (de)
ME (2) ME00238B (de)
MY (1) MY126795A (de)
NL (1) NL300398I2 (de)
NO (2) NO331027B1 (de)
NZ (1) NZ510529A (de)
PL (1) PL219605B1 (de)
PT (3) PT1124961E (de)
RS (1) RS51237B (de)
SI (3) SI1783222T1 (de)
SK (1) SK287737B6 (de)
TW (2) TWI250988B (de)
WO (1) WO2000024770A2 (de)
ZA (1) ZA200102102B (de)

Families Citing this family (150)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7091311B2 (en) * 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
JP3820105B2 (ja) * 1998-10-23 2006-09-13 キリン−アムジエン・インコーポレーテツド Ｍｐ１受容体に結合し血小板生成活性を有する二量体トロンボポエチンペプチド模倣体
US6808902B1 (en) * 1999-11-12 2004-10-26 Amgen Inc. Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
WO2001081377A2 (en) * 2000-04-21 2001-11-01 Amgen, Inc. Integrin/adhesion antagonists
US20020090646A1 (en) * 2000-05-03 2002-07-11 Amgen Inc. Calcitonin-related molecules
JP2004503512A (ja) * 2000-06-09 2004-02-05 アメリカ合衆国 免疫複合体の抗腫瘍活性を改善し、かつ、毒性を低減するリンカーのｐｅｇ化
US7396917B2 (en) * 2000-12-05 2008-07-08 Alexion Pharmaceuticals, Inc. Rationally designed antibodies
DK1642910T3 (da) 2000-12-05 2012-05-07 Alexion Pharma Inc Rationelt designede atistoffer
US20040018203A1 (en) * 2001-06-08 2004-01-29 Ira Pastan Pegylation of linkers improves antitumor activity and reduces toxicity of immunoconjugates
WO2003016351A2 (en) 2001-08-17 2003-02-27 Enkam Pharmaceuticals A/S N - cam related compounds modulating cell groth
US7332474B2 (en) 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
US20030191056A1 (en) 2002-04-04 2003-10-09 Kenneth Walker Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
US8067367B2 (en) * 2002-09-18 2011-11-29 Janssen Pharmaceutica, N.V. Methods of increasing platelet and hematopoietic stem cell production
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
NZ543934A (en) 2003-05-12 2008-06-30 Affymax Inc Novel spacer moiety for poly (ethylene glycol)-modified peptide-based compounds
KR101163683B1 (ko) 2003-05-12 2012-07-10 아피맥스, 인크. 에리스로포이에틴 수용체에 결합하는 신규의 펩티드
CA2525464A1 (en) * 2003-05-12 2004-11-25 Qun Yin Novel poly(ethylene glycol) modified compounds and uses thereof
KR101227666B1 (ko) 2003-05-12 2013-01-31 아피맥스, 인크. 에리스로포이에틴 수용체에 결합하는 펩티드
ES2390082T5 (es) * 2004-06-30 2018-01-19 Nektar Therapeutics Conjugados de resto de Factor IX y polímeros
EP1773400A2 (de) * 2004-07-08 2007-04-18 Amgen Inc. Therapeutische peptide
US7550433B2 (en) 2005-06-03 2009-06-23 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
EP1907417A2 (de) * 2005-06-23 2008-04-09 AplaGen GmbH Supravalentverbindungen
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
WO2007075899A2 (en) * 2005-12-21 2007-07-05 Maxygen, Inc. Dual agonist compounds and uses thereof
US9012605B2 (en) 2006-01-23 2015-04-21 Amgen Inc. Crystalline polypeptides
US20090053242A1 (en) * 2006-01-25 2009-02-26 Amgen Inc. Thrombopoietic compounds
US9283260B2 (en) 2006-04-21 2016-03-15 Amgen Inc. Lyophilized therapeutic peptibody formulations
US7981425B2 (en) 2006-06-19 2011-07-19 Amgen Inc. Thrombopoietic compounds
EP2044197B8 (de) * 2006-07-24 2018-03-07 The University Of Queensland Verfahren zur herstellung einer zellpopulation
EP2118127A4 (de) 2007-01-31 2010-12-01 Affymax Inc Linker auf stickstoffbasis zur bindung modifizierender gruppen an polypeptide und andere makromoleküle
MX2009012609A (es) 2007-05-22 2009-12-07 Amgen Inc Composiciones y metodos para producir proteinas de fusion bioactivas.
US20090054332A1 (en) * 2007-06-21 2009-02-26 Conjuchem Biotechnologies, Inc. Thombopoietin peptide conjugates
MX2010002249A (es) * 2007-08-31 2010-03-17 Amgen Inc Formulacion de proteina de estado solido.
AU2008304111B2 (en) 2007-09-27 2014-04-24 Amgen Inc. Pharmaceutical formulations
EP3381445B1 (de) 2007-11-15 2023-10-25 Amgen Inc. Wässrige antikörperformulierung mit stabilisierung durch antioxidantien zur parenteralen verabreichung
US8470964B2 (en) 2007-11-28 2013-06-25 Enkam Pharmaceuticals A/S Peptides derived from NCAM (FGLs)
CA2889453C (en) 2009-03-20 2018-11-06 Amgen Inc. Carrier immunoglobulins and uses thereof
SG175004A1 (en) 2009-04-02 2011-11-28 Roche Glycart Ag Multispecific antibodies comprising full length antibodies and single chain fab fragments
RU2573915C2 (ru) 2009-09-16 2016-01-27 Дженентек, Инк. Содержащие суперспираль и/или привязку белковые комплексы и их применение
US20120253009A1 (en) * 2009-10-16 2012-10-04 Amgen Inc. Thrombopoietic compounds
MX344382B (es) 2009-10-23 2016-12-14 Amgen Inc * Adaptador de vial y sistema.
WO2011098095A1 (en) 2010-02-09 2011-08-18 Aplagen Gmbh Peptides binding the tpo receptor
AR080793A1 (es) 2010-03-26 2012-05-09 Roche Glycart Ag Anticuerpos biespecificos
ES2617777T5 (es) 2010-04-23 2022-10-13 Hoffmann La Roche Producción de proteínas heteromultiméricas
WO2011156373A1 (en) 2010-06-07 2011-12-15 Amgen Inc. Drug delivery device
CN103154032A (zh) 2010-08-13 2013-06-12 弗·哈夫曼-拉罗切有限公司 用于疾病治疗的针对IL-1β和IL-18的抗体
CA2807278A1 (en) 2010-08-24 2012-03-01 F. Hoffmann - La Roche Ag Bispecific antibodies comprising a disulfide stabilized - fv fragment
KR20130110169A (ko) 2010-09-22 2013-10-08 암젠 인크 담체 면역글로뷸린 및 이것의 용도
EP2655413B1 (de) 2010-12-23 2019-01-16 F.Hoffmann-La Roche Ag Polypeptid-polynukleotid-komplex und verwendung bei der gezielten effektorrest-bereitstellung
EP2670776B1 (de) 2011-02-04 2018-11-21 F. Hoffmann-La Roche AG Fc-varianten und verfahren zu ihrer herstellung
US10689447B2 (en) 2011-02-04 2020-06-23 Genentech, Inc. Fc variants and methods for their production
US9480624B2 (en) 2011-03-31 2016-11-01 Amgen Inc. Vial adapter and system
EP2699293B8 (de) 2011-04-20 2022-07-20 Amgen Inc. Autoinjektorvorrichtung
WO2013055958A1 (en) 2011-10-11 2013-04-18 Genentech, Inc. Improved assembly of bispecific antibodies
HUE043691T2 (hu) 2011-10-14 2019-09-30 Amgen Inc Befecskendezõ eszköz és összeszerelési eljárás
JP6486686B2 (ja) 2012-02-10 2019-03-20 ジェネンテック， インコーポレイテッド 単鎖抗体及び他のヘテロ多量体
CN102552184A (zh) * 2012-02-16 2012-07-11 山东泉港药业有限公司 一种血小板生成素拟肽冻干制剂
CA2871882A1 (en) 2012-06-27 2014-01-03 F. Hoffmann-La Roche Ag Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof
CN104395339A (zh) 2012-06-27 2015-03-04 弗·哈夫曼-拉罗切有限公司 用于选择并产生含有至少两种不同结合实体的定制高度选择性和多特异性靶向实体的方法及其用途
EP4234694A3 (de) 2012-11-21 2023-09-06 Amgen Inc. Arzneimittelabgabevorrichtung
TWI639453B (zh) 2013-03-15 2018-11-01 美商安美基公司 用於注射器之匣盒
CN104046642B (zh) * 2013-03-15 2018-07-06 兰州大学 发酵生产二聚体化融合蛋白的方法
TWI592183B (zh) 2013-03-15 2017-07-21 安美基公司 本體輪廓可調適之自動注射器裝置
CN104045715B (zh) * 2013-03-15 2018-05-01 兰州大学 二聚体化融合蛋白的制备及应用
JP6336564B2 (ja) 2013-03-15 2018-06-06 アムゲン・インコーポレーテッド 薬物カセット、自動注入器、および自動注入器システム
EP2976117B1 (de) 2013-03-22 2020-12-30 Amgen Inc. Injektor und verfahren zur montage
AU2014340171B2 (en) 2013-10-24 2019-05-30 Amgen Inc. Injector and method of assembly
EP3501575B1 (de) 2013-10-24 2021-12-01 Amgen Inc. Arzneimittelabgabesystem mit temperaturempfindlicher steuerung
US10994112B2 (en) 2014-02-05 2021-05-04 Amgen Inc. Drug delivery system with electromagnetic field generator
CN105017408B (zh) * 2014-04-30 2019-11-05 重庆派金生物科技有限公司 聚乙二醇化血小板生成素模拟肽同源四聚体及其用途
EP4306544A3 (de) 2014-05-06 2024-03-20 F. Hoffmann-La Roche AG Herstellung heteromultimerer proteine unter verwendung von säugetierzellen
MX2016014561A (es) 2014-05-07 2017-06-21 Amgen Inc Autoinyetor con elementos reductores del shock.
MX2016015854A (es) 2014-06-03 2017-07-19 Amgen Inc Sistema de suministro de farmacos controlable y metodo de uso.
JP6655011B2 (ja) * 2014-06-23 2020-02-26 東亞合成株式会社 細胞の多核化を誘導するペプチドおよびその利用
MA40524A (fr) * 2014-09-26 2021-03-17 Bayer Pharma AG Dérivés d'adrénomédulline stabilisés et leur utilisation
EP3943135A3 (de) 2014-10-14 2022-06-29 Amgen Inc. Arzneimittelinjektionsvorrichtung mit visuellen und hörbaren indikatoren
JP6721590B2 (ja) 2014-12-03 2020-07-15 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 多重特異性抗体
EP3233163B1 (de) 2014-12-19 2021-10-13 Amgen Inc. Medikamentenabgabevorrichtung mit näherungssensor
ES2785311T3 (es) 2014-12-19 2020-10-06 Amgen Inc Dispositivo de administración de fármacos con botón móvil o campo de interfaz de usuario
WO2016129656A1 (ja) * 2015-02-12 2016-08-18 国立大学法人岩手大学 哺乳動物細胞に対する外来遺伝子の導入効率の向上剤
WO2016133947A1 (en) 2015-02-17 2016-08-25 Amgen Inc. Drug delivery device with vacuum assisted securement and/or feedback
JP2018512184A (ja) 2015-02-27 2018-05-17 アムジエン・インコーポレーテツド 針ガードの移動に対する抵抗力の閾値が調整可能な針ガード機構を備えた薬物送達装置
WO2017039786A1 (en) 2015-09-02 2017-03-09 Amgen Inc. Syringe assembly adapter for a syringe
EP3386573B1 (de) 2015-12-09 2019-10-02 Amgen Inc. Autoinjektor mit signalhaube
US11154661B2 (en) 2016-01-06 2021-10-26 Amgen Inc. Auto-injector with signaling electronics
WO2017160799A1 (en) 2016-03-15 2017-09-21 Amgen Inc. Reducing probability of glass breakage in drug delivery devices
WO2017189089A1 (en) 2016-04-29 2017-11-02 Amgen Inc. Drug delivery device with messaging label
WO2017192287A1 (en) 2016-05-02 2017-11-09 Amgen Inc. Syringe adapter and guide for filling an on-body injector
MX2018013616A (es) 2016-05-13 2019-02-21 Amgen Inc Montaje de cubierta protectora de vial.
EP3458988B1 (de) 2016-05-16 2023-10-18 Amgen Inc. Datenverschlüsselung in medizinischen vorrichtungen mit eingeschränkter rechenfähigkeit
EP3465124A1 (de) 2016-06-03 2019-04-10 Amgen Inc. Wirkungstestvorrichtungen und verfahren für wirkstofffreisetzungsvorrichtungen
WO2018004842A1 (en) 2016-07-01 2018-01-04 Amgen Inc. Drug delivery device having minimized risk of component fracture upon impact events
US20190328965A1 (en) 2016-08-17 2019-10-31 Amgen Inc. Drug delivery device with placement detection
US20200261643A1 (en) 2016-10-25 2020-08-20 Amgen Inc. On-body injector
CN108264547B (zh) * 2016-12-30 2021-09-21 四川科伦博泰生物医药股份有限公司 一种纯化蛋白的方法以及试剂盒
JP2020503976A (ja) 2017-01-17 2020-02-06 アムジエン・インコーポレーテツド 注入デバイスならびに関連する使用および組立方法
EP3582825A1 (de) 2017-02-17 2019-12-25 Amgen Inc. Wirkstofffreisetzungsvorrichtung mit steriler fluidströmung und zugehöriges verfahren zur montage
AU2018221351B2 (en) 2017-02-17 2023-02-23 Amgen Inc. Insertion mechanism for drug delivery device
JP2020508803A (ja) 2017-03-06 2020-03-26 アムジエン・インコーポレーテツド 作動防止特徴部を備える薬物送達デバイス
AU2018230546B2 (en) 2017-03-07 2024-03-21 Amgen Inc. Needle insertion by overpressure
US11986624B2 (en) 2017-03-09 2024-05-21 Amgen Inc. Insertion mechanism for drug delivery device
DK3600491T3 (da) 2017-03-28 2023-10-23 Amgen Inc Stempelstang og sprøjtekonstruktionssystem samt fremgangsmåde
EP3634539A1 (de) 2017-06-08 2020-04-15 Amgen Inc. Spritzenanordnung für eine wirkstofffreisetzungsvorrichtung und verfahren zur montage
MX2019014615A (es) 2017-06-08 2020-02-07 Amgen Inc Dispositivo de administracion de farmacos accionado por par de torsion.
WO2018236619A1 (en) 2017-06-22 2018-12-27 Amgen Inc. REDUCING THE IMPACTS / IMPACTS OF ACTIVATION OF A DEVICE
US11395880B2 (en) 2017-06-23 2022-07-26 Amgen Inc. Electronic drug delivery device
EP3651832B1 (de) 2017-07-14 2023-12-13 Amgen Inc. Nadeleinführ-retraktionssystem mit doppeltorsionsfedersystem
US11672733B2 (en) 2017-07-21 2023-06-13 Amgen Inc. Gas permeable sealing member for drug container and methods of assembly
EP4085942A1 (de) 2017-07-25 2022-11-09 Amgen Inc. Arzneimittelabgabevorrichtung mit getriebemodul und verwandtes verfahren zur montage
EP3658206A1 (de) 2017-07-25 2020-06-03 Amgen Inc. Arzneimittelabgabevorrichtung mit behälterzugangssystem und zugehörigem verfahren zur montage
WO2019032482A2 (en) 2017-08-09 2019-02-14 Amgen Inc. HYDRAULIC-PNEUMATIC PRESSURE CHAMBER DELIVERY SYSTEM
EP3668567A1 (de) 2017-08-18 2020-06-24 Amgen Inc. Am körper tragbarer injektor mit sterilem klebepflaster
US11103636B2 (en) 2017-08-22 2021-08-31 Amgen Inc. Needle insertion mechanism for drug delivery device
EP3691717B1 (de) 2017-10-04 2023-02-08 Amgen Inc. Durchflussadapter für arzneimittelabgabevorrichtung
ES2971450T3 (es) 2017-10-06 2024-06-05 Amgen Inc Dispositivo de administración de fármacos con conjunto de enclavamiento y procedimiento de montaje correspondiente
MA50348A (fr) 2017-10-09 2020-08-19 Amgen Inc Dispositif d'administration de médicament comprenant un ensemble d'entraînement et procédé d'assemblage associé
US11305026B2 (en) 2017-11-03 2022-04-19 Amgen Inc. Systems and approaches for sterilizing a drug delivery device
WO2019090303A1 (en) 2017-11-06 2019-05-09 Amgen Inc. Fill-finish assemblies and related methods
EP3706830B1 (de) 2017-11-06 2024-08-07 Amgen Inc. Arzneimittelabgabevorrichtung mit positionierungs- und durchflussmessung
CA3079665A1 (en) 2017-11-10 2019-05-16 Amgen Inc. Plungers for drug delivery devices
JP7370969B2 (ja) 2017-11-16 2023-10-30 アムジエン・インコーポレーテツド 薬物送達デバイスの扉ラッチ機構
MA50903A (fr) 2017-11-16 2021-05-12 Amgen Inc Auto-injecteur avec détection de décrochage et de point d'extrémité
US10835685B2 (en) 2018-05-30 2020-11-17 Amgen Inc. Thermal spring release mechanism for a drug delivery device
US11083840B2 (en) 2018-06-01 2021-08-10 Amgen Inc. Modular fluid path assemblies for drug delivery devices
EP3586860A1 (de) * 2018-06-22 2020-01-01 Universität Ulm Komplement-inhibitoren und verwendungen davon
US20210260279A1 (en) 2018-07-24 2021-08-26 Amgen Inc. Hybrid drug delivery devices with optional grip portion and related method of preparation
US12042645B2 (en) 2018-07-24 2024-07-23 Amgen Inc. Delivery devices for administering drugs
MA53375A (fr) 2018-07-24 2021-06-02 Amgen Inc Dispositifs d'administration pour l'administration de médicaments
US12115360B2 (en) 2018-07-24 2024-10-15 Amgen Inc. Hybrid drug delivery devices with grip portion
CA3103105A1 (en) 2018-07-31 2020-02-06 Amgen Inc. Fluid path assembly for a drug delivery device
JP2022500095A (ja) 2018-09-24 2022-01-04 アムジエン・インコーポレーテツド インターベンション投薬システム及び方法
IL281469B2 (en) 2018-09-28 2024-08-01 Amgen Inc Assembling a memory alloy ejector activation assembly for a drug delivery device
WO2020072577A1 (en) 2018-10-02 2020-04-09 Amgen Inc. Injection systems for drug delivery with internal force transmission
MA53818A (fr) 2018-10-05 2022-01-12 Amgen Inc Dispositif d'administration de médicament ayant un indicateur de dose
EA202191038A1 (ru) 2018-10-15 2021-07-06 Эмджен Инк. Способ платформенной сборки для устройства доставки лекарственного средства
AR116704A1 (es) 2018-10-15 2021-06-02 Amgen Inc Dispositivo de administración de fármacos con mecanismo de amortiguación
US20210379154A1 (en) * 2018-10-26 2021-12-09 Kyowa Kirin Co., Ltd. Pharmaceutical composition for treating aplastic anemia
TWI831847B (zh) 2018-11-01 2024-02-11 美商安進公司 部分針頭縮回之藥物遞送裝置及其操作方法
US11213620B2 (en) 2018-11-01 2022-01-04 Amgen Inc. Drug delivery devices with partial drug delivery member retraction
AU2019370159A1 (en) 2018-11-01 2021-04-22 Amgen Inc. Drug delivery devices with partial drug delivery member retraction
MX2021012557A (es) 2019-04-24 2021-11-12 Amgen Inc Conjuntos y metodos de verificacion de esterilizacion de jeringuillas.
WO2021041067A2 (en) 2019-08-23 2021-03-04 Amgen Inc. Drug delivery device with configurable needle shield engagement components and related methods
WO2022129460A1 (en) 2020-12-18 2022-06-23 Richter Gedeon Nyrt. Methods for the purification of refolded fc-peptide fusion protein
CN113402614A (zh) * 2021-04-22 2021-09-17 山东泉港药业有限公司 血小板生成素拟肽融合蛋白(fc-tmp)编码基因与应用
US20240208680A1 (en) 2021-05-21 2024-06-27 Amgen Inc. Method of optimizing a filling recipe for a drug container
WO2023044774A1 (en) * 2021-09-24 2023-03-30 Sichuan Clover Biopharmaceuticals, Inc. Tpo mimetic fusion proteins and methods of use submission of sequence listing as ascii text file
WO2023149443A1 (ja) 2022-02-02 2023-08-10 国立大学法人 筑波大学 臍帯血移植後の血球回復のための医薬組成物
WO2023180525A1 (en) 2022-03-24 2023-09-28 Richter Gedeon Nyrt. Method for the manufacture of biopharmaceuticals
WO2024036324A1 (en) 2022-08-11 2024-02-15 Selecta Biosciences, Inc. Compositions and methods related to immunoglobulin proteases and fusions thereof
CN117986346B (zh) * 2024-04-07 2024-07-26 中国人民解放军军事科学院军事医学研究院 一种tpo模拟肽及其应用

Family Cites Families (179)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA705953B (en) * 1969-09-01 1971-09-29 Geetainers Ltd Cover-lock for containers
US3691016A (en) 1970-04-17 1972-09-12 Monsanto Co Process for the preparation of insoluble enzymes
CA1023287A (en) 1972-12-08 1977-12-27 Boehringer Mannheim G.M.B.H. Process for the preparation of carrier-bound proteins
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US3941763A (en) 1975-03-28 1976-03-02 American Home Products Corporation PGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 and intermediates
US4002531A (en) * 1976-01-22 1977-01-11 Pierce Chemical Company Modifying enzymes with polyethylene glycol and product produced thereby
US4195128A (en) 1976-05-03 1980-03-25 Bayer Aktiengesellschaft Polymeric carrier bound ligands
US4330440A (en) 1977-02-08 1982-05-18 Development Finance Corporation Of New Zealand Activated matrix and method of activation
CA1093991A (en) 1977-02-17 1981-01-20 Hideo Hirohara Enzyme immobilization with pullulan gel
US4229537A (en) 1978-02-09 1980-10-21 New York University Preparation of trichloro-s-triazine activated supports for coupling ligands
US4289872A (en) 1979-04-06 1981-09-15 Allied Corporation Macromolecular highly branched homogeneous compound based on lysine units
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4503235A (en) 1983-03-11 1985-03-05 Warner-Lambert Company Process for producing 4-carbamoyl-1H-imidazolium-5-olate
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
DE3572982D1 (en) 1984-03-06 1989-10-19 Takeda Chemical Industries Ltd Chemically modified lymphokine and production thereof
EP0173494A3 (de) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimäre Rezeptoren durch Verbindung und Expression von DNS
DE3675588D1 (de) 1985-06-19 1990-12-20 Ajinomoto Kk Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
US5017691A (en) * 1986-07-03 1991-05-21 Schering Corporation Mammalian interleukin-4
US5985599A (en) * 1986-05-29 1999-11-16 The Austin Research Institute FC receptor for immunoglobulin
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
NL8720442A (nl) 1986-08-18 1989-04-03 Clinical Technologies Ass Afgeefsystemen voor farmacologische agentia.
US5229490A (en) 1987-05-06 1993-07-20 The Rockefeller University Multiple antigen peptide system
US5336603A (en) 1987-10-02 1994-08-09 Genentech, Inc. CD4 adheson variants
DE3889853D1 (de) 1987-11-05 1994-07-07 Hybritech Inc Polysaccharidmodifizierte Immunglobuline mit reduziertem immunogenem Potential oder verbesserter Pharmakokinetik.
US4904584A (en) * 1987-12-23 1990-02-27 Genetics Institute, Inc. Site-specific homogeneous modification of polypeptides
ES2092468T3 (es) 1988-01-22 1996-12-01 Zymogenetics Inc Metodos para producir analogos de receptores secretados.
CA1340810C (en) 1988-03-31 1999-11-02 Motoo Yamasaki Polypeptide derivatives of human granulocyte colony stimulating factor
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB8824591D0 (en) 1988-10-20 1988-11-23 Royal Free Hosp School Med Fractionation process
CA2006596C (en) 1988-12-22 2000-09-05 Rika Ishikawa Chemically-modified g-csf
EP1201756A3 (de) * 1988-12-22 2002-10-30 Genentech, Inc. Verfahren zur Herstellung von wasserlöslichen Polypeptiden
US5089261A (en) * 1989-01-23 1992-02-18 Cetus Corporation Preparation of a polymer/interleukin-2 conjugate
US4902502A (en) 1989-01-23 1990-02-20 Cetus Corporation Preparation of a polymer/interleukin-2 conjugate
US5216131A (en) * 1989-02-23 1993-06-01 Genentech, Inc. Lymphocyte homing receptors
US5116964A (en) 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
US5225538A (en) 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
US5098833A (en) * 1989-02-23 1992-03-24 Genentech, Inc. DNA sequence encoding a functional domain of a lymphocyte homing receptor
US5627262A (en) * 1989-07-05 1997-05-06 The Board Of Regents Of The University Of Oklahoma Method and composition for the treatment of septic shock
EP1132471A3 (de) * 1989-09-12 2001-11-28 F. Hoffmann-La Roche Ag TNF-bindende Proteine
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
JPH04218000A (ja) 1990-02-13 1992-08-07 Kirin Amgen Inc 修飾ポリペプチド
US5723286A (en) * 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
JPH06508511A (ja) 1990-07-10 1994-09-29 ケンブリッジ　アンティボディー　テクノロジー　リミティド 特異的な結合ペアーの構成員の製造方法
EP0714912B1 (de) 1990-07-17 2002-09-25 The Board Of Regents Of The University Of Oklahoma GMP-140 Ligand
IE912365A1 (en) 1990-07-23 1992-01-29 Zeneca Ltd Continuous release pharmaceutical compositions
US5252714A (en) * 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
SG47099A1 (en) 1991-03-15 1998-03-20 Amgen Boulder Inc Pegylation of polypeptides
CA2082951C (en) 1991-03-15 1999-12-21 Robert M. Platz Pulmonary administration of granulocyte colony stimulating factor
US5595732A (en) * 1991-03-25 1997-01-21 Hoffmann-La Roche Inc. Polyethylene-protein conjugates
US6139843A (en) 1991-04-02 2000-10-31 Albert Einstein College Of Medicine Of Yeshiva University Peptide compositions for the treatment of HIV
US5281698A (en) * 1991-07-23 1994-01-25 Cetus Oncology Corporation Preparation of an activated polymer ester for protein conjugation
US5362852A (en) * 1991-09-27 1994-11-08 Pfizer Inc. Modified peptide derivatives conjugated at 2-hydroxyethylamine moieties
US5733731A (en) 1991-10-16 1998-03-31 Affymax Technologies N.V. Peptide library and screening method
US5270170A (en) * 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
NZ244778A (en) 1991-10-21 1994-03-25 Ortho Pharma Corp Peg imidates and protein derivatives thereof
DK0667901T4 (da) * 1991-10-25 2008-11-10 Immunex Corp Hidtil ukendt cytokin
US5376367A (en) * 1991-11-22 1994-12-27 Immunex Corporation Fusion proteins comprising MGF and IL-3
JPH07505915A (ja) 1992-04-14 1995-06-29 コーネル　リサーチ　ファウンデーション、インコーポレーテッド 樹枝状巨大分子およびその製造法
DK0615451T3 (da) 1992-05-26 2006-04-24 Immunex Corp Hidtil ukendt cytokin der binder til CD30
US5792451A (en) 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
DE69332485T2 (de) * 1992-08-11 2003-11-13 The President And Fellows Of Harvard College, Cambridge Immunmodulierende peptide
SG41929A1 (en) * 1992-09-25 1997-08-15 Commw Scient Ind Res Org Target binding polypeptide
GB9225448D0 (en) 1992-12-04 1993-01-27 Erba Carlo Spa Improved synthesis of polymer bioactive conjugates
NZ247231A (en) * 1993-03-23 1994-10-26 Holyoake Ind Ltd Diffuser for air conditioning system; outlet air direction thermostatically controlled
WO1995009917A1 (en) 1993-10-07 1995-04-13 The Regents Of The University Of California Genetically engineered bispecific tetravalent antibodies
US5922545A (en) * 1993-10-29 1999-07-13 Affymax Technologies N.V. In vitro peptide and antibody display libraries
US5773569A (en) * 1993-11-19 1998-06-30 Affymax Technologies N.V. Compounds and peptides that bind to the erythropoietin receptor
US5981478A (en) 1993-11-24 1999-11-09 La Jolla Cancer Research Foundation Integrin-binding peptides
GB2285446B (en) 1994-01-03 1999-07-28 Genentech Inc Thrombopoietin
US5880096A (en) * 1994-02-02 1999-03-09 Affymax Technologies N.V. Peptides and compounds that bind to the IL-1 receptor
US5608035A (en) * 1994-02-02 1997-03-04 Affymax Technologies N.V. Peptides and compounds that bind to the IL-1 receptor
US5786331A (en) * 1994-02-02 1998-07-28 Affymax Technologies N.V. Peptides and compounds that bind to the IL-1 receptor
WO1995021920A1 (en) 1994-02-14 1995-08-17 Zymogenetics, Inc. Hematopoietic protein and materials and methods for making it
KR100260272B1 (ko) * 1994-02-14 2000-07-01 마나배 게이사꾸 Tpo활성을 갖는 단백질의 아미노산을 코딩하는 염기 서열을 포함하는 dna
WO1995021919A2 (en) 1994-02-14 1995-08-17 Kirin Brewery Company, Limited Protein having tpo activity
US5795569A (en) * 1994-03-31 1998-08-18 Amgen Inc. Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
KR100203824B1 (ko) 1994-03-31 1999-06-15 스티븐 엠. 오드리 거핵구 성장 및 분화를 자극하기 위한 조성물 및방법
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
IL111196A0 (en) 1994-10-07 1994-12-29 Yeda Res & Dev Peptides and pharmaceutical compositions comprising them
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
AU693478B2 (en) * 1994-11-10 1998-07-02 Metabolic Pharmaceuticals Limited Treatment of obesity
IL116026A (en) * 1994-11-22 2005-08-31 Rhone Poulenc Rorer Sa Peptides capable of linking to the sh3 domain of gap, nucleotide sequences encoding the same, their preparation and uses
JP3511321B2 (ja) * 1994-11-29 2004-03-29 出光興産株式会社 スチレン系重合体の分子量制御方法
US5641655A (en) * 1994-11-30 1997-06-24 Zymogenetics, Inc. Methods for producing thrombopoietin polypeptides using a mammalian tissue plasminogen activator secretory peptide
AU700605B2 (en) 1994-12-07 1999-01-07 Bionebraska, Inc. Production of peptides using recombinant fusion protein constructs
EP1621206A1 (de) 1994-12-12 2006-02-01 Beth Israel Deaconess Medical Center, Inc. Chimäre Zytokine und ihre Verwendung
US5888763A (en) * 1994-12-30 1999-03-30 The Rockefeller University Peptides specific for the first Crk-SH3 domain
WO1996023899A1 (en) 1995-02-01 1996-08-08 University Of Massachusetts Medical Center Methods of selecting a random peptide that binds to a target protein
IL113159A0 (en) 1995-03-28 1995-06-29 Yeda Res & Dev Synthetic peptides and pharmaceutical compositions comprising them
US5739277A (en) 1995-04-14 1998-04-14 Genentech Inc. Altered polypeptides with increased half-life
US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
US6251864B1 (en) * 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
PL188795B1 (pl) 1995-06-07 2005-04-29 Glaxo Group Ltd Związek wiążący się z receptorem trombopoetyny, kompozycja farmaceutyczna i zastosowanie związku wiążącego się z receptorem trombopoetyny
WO1996040189A1 (en) * 1995-06-07 1996-12-19 Glaxo Group Limited Peptides and compounds that bind to a receptor
US5767078A (en) 1995-06-07 1998-06-16 Johnson; Dana L. Agonist peptide dimers
IL118524A (en) 1995-06-19 2004-02-19 Akzo Nobel Nv Peptides and pharmaceutical preparations containing them useful in the treatment of peptide tolerance
SI2275119T1 (sl) 1995-07-27 2013-12-31 Genentech, Inc. Stabilna izotonična liofilizirana proteinska formulacija
US5746516A (en) * 1995-08-11 1998-05-05 Hitachi Powdered Metals Co., Ltd. Porous bearing system having internal grooves and electric motor provided with the same
WO1997008553A1 (en) 1995-08-22 1997-03-06 The Regents Of The University Of California Targeting of proteins to the cell wall of gram-positive bacteria
US5817750A (en) 1995-08-28 1998-10-06 La Jolla Cancer Research Foundation Structural mimics of RGD-binding sites
JPH09151200A (ja) 1995-09-29 1997-06-10 Ajinomoto Co Inc ヒト胃癌に対する免疫応答を誘導できるペプチド及び該ペプチドを含むヒト胃癌治療、予防剤
US5670110A (en) 1995-12-21 1997-09-23 The Procter & Gamble Company Method for making three-dimensional macroscopically-expanded webs having improved functional surfaces
US6369027B1 (en) 1995-12-22 2002-04-09 Amgen Inc. Osteoprotegerin
CN1154971A (zh) * 1996-01-19 1997-07-23 北京医科大学 血小板生长因子(tpo)及其制备方法和用途
US5714577A (en) * 1996-01-26 1998-02-03 University Of Pittsburgh Antimicrobial peptides
CA2539273C (en) 1996-02-09 2014-02-04 Amgen Inc. A fusion protein comprising an interleukin-1 receptor antagonist and uses thereof
IL117223A0 (en) 1996-02-22 1996-06-18 Yeda Res & Dev Antipathogenic polypeptides and compositions comprising them
AU728657B2 (en) 1996-03-18 2001-01-18 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
WO1997035969A2 (en) 1996-03-28 1997-10-02 Chiron Corporation Peptide ligands of the urokinase receptor
IL118003A0 (en) 1996-04-23 1996-08-04 Yeda Res & Dev Novel vip fragments and pharmaceutical compositions comprising them
FR2748028B1 (fr) 1996-04-30 1998-08-14 Lab Francais Du Fractionnement Peptides derives du facteur von willebrand et leur utilisation comme anticoagulant
US6100071A (en) 1996-05-07 2000-08-08 Genentech, Inc. Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production
AU2978697A (en) 1996-06-07 1998-01-05 Takeda Chemical Industries Ltd. Novel peptide, process for the production of the same, and use of the same
US6126939A (en) 1996-09-03 2000-10-03 Yeda Research And Development Co. Ltd. Anti-inflammatory dipeptide and pharmaceutical composition thereof
DE69734887T2 (de) 1996-09-10 2006-08-24 The Burnham Institute, La Jolla Tumor findende moleküle, davon abstammende konjugate und verfahren zu deren verwendung
US5932546A (en) 1996-10-04 1999-08-03 Glaxo Wellcome Inc. Peptides and compounds that bind to the thrombopoietin receptor
JP2001512560A (ja) 1996-10-08 2001-08-21 ユー―ビスイス ベスローテン フェンノートシャップ 標的に対し特異的な親和性を有するペプチドおよびタンパク質の選択のための方法および手段
ES2312179T3 (es) 1996-12-06 2009-02-16 Amgen Inc. Terapia combinada que utiliza un inhibidor del il-1 para el tratamiento de enfermedades mediadas por el il-1.
NZ514145A (en) 1996-12-20 2003-08-29 Amgen Inc OB fusion protein compositions and methods
KR19980066046A (ko) 1997-01-18 1998-10-15 정용훈 고역가의 CTLA4-Ig 융합단백질
WO1998033812A1 (en) 1997-02-05 1998-08-06 Brigham And Women's Hospital, Inc. Mast cell protease peptide inhibitors
US5863735A (en) 1997-02-24 1999-01-26 Incyte Pharmaceuticals, Inc. Human transmembrane 4 superfamily protein
EP1717315A3 (de) 1997-04-16 2007-06-20 Amgen Inc. Osteoprotegerin bindende Proteine und Rezeptoren
AU7132798A (en) 1997-04-17 1998-11-11 Amgen, Inc. Compositions comprising conjugates of stable, active, human ob protein with antibody fc chain and methods
US6265535B1 (en) 1997-05-30 2001-07-24 The Trustees Of The University Of Pennsylvania Peptides and peptide analogues designed from binding sites of tumor necrosis factor receptor superfamily and their uses
AU743490B2 (en) 1997-06-06 2002-01-24 Regeneron Pharmaceuticals, Inc. NTN-2 member of TNF ligand family
DE69827260T2 (de) 1997-07-24 2006-02-16 PerSeptive Biosystems, Inc., Framingham Konjugate von transportpeptiden und nukleinsäureanaloga und deren verwendung
US6342220B1 (en) 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
US6238667B1 (en) 1997-09-19 2001-05-29 Heinz Kohler Method of affinity cross-linking biologically active immunogenic peptides to antibodies
CA2306246A1 (en) 1997-10-06 1999-04-15 Millennium Pharmaceuticals, Inc. Signal peptide containing proteins and uses therefor
AU741203B2 (en) 1997-10-10 2001-11-22 Cytovia, Inc. Dipeptide apoptosis inhibitors and the use thereof
WO1999024076A2 (en) 1997-11-07 1999-05-20 Conjuchem, Inc. Salicylate derivatized therapeutic and diagnostic agents
WO1999038526A1 (en) 1998-01-29 1999-08-05 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Variant peptide ligands that selectively induce apoptosis
US6162613A (en) 1998-02-18 2000-12-19 Vertex Pharmaceuticals, Inc. Methods for designing inhibitors of serine/threonine-kinases and tyrosine kinases
ATE279430T1 (de) * 1998-03-05 2004-10-15 Chiron Corp Verfahren zur verbesserung der serum halbwertszeit von biologisch aktiven molekülen
US6235872B1 (en) 1998-03-12 2001-05-22 The Burnham Institute Proapoptotic peptides dependence polypeptides and methods of use
JP4361684B2 (ja) 1998-03-20 2009-11-11 中外製薬株式会社 エリトロポエチン受容体のためのペプチドリガンド
EP0947524A1 (de) 1998-03-30 1999-10-06 Upither B.V. Neue Peptide zur Behandlung von Autoimmunkrankheiten
EP1075270B1 (de) 1998-04-06 2005-06-15 Advanced Immunit, Inc. Kurzes peptid zur behandlung neurodegenerativer erkrankungen
ES2242396T3 (es) * 1998-04-28 2005-11-01 Applied Research Systems Ars Holding N.V. Conjugados de analogos de peg-lhrh.
EP0972780A1 (de) 1998-05-18 2000-01-19 Applied Research Systems ARS Holding N.V. Il-6-Antagonistische Peptide
DE69823981T2 (de) 1998-05-21 2005-05-25 Tecnogen S.C.P.A., Piana De Monte Verna Verwendung von Peptidverbindungen zur Behandlung von SLE
AU764277B2 (en) 1998-05-22 2003-08-14 Abbvie Inc. Peptide antiangiogenic drugs
US5932548A (en) 1998-06-03 1999-08-03 Deghenghi; Romano Lysine containing peptides for treatment of heart disease
WO2000001402A1 (en) 1998-07-02 2000-01-13 Envision Biomedical Consulting Antiproliferative and antiviral proteins and peptides
US6168785B1 (en) 1998-07-16 2001-01-02 Institut Pasteur Biological applications of new peptides of IL-2 and derivatives and use as therapeutic agents
JP2002522063A (ja) 1998-08-17 2002-07-23 アブジェニックス インコーポレイテッド 増加した血清半減期を有する改変された分子の生成
WO2000011028A2 (en) 1998-08-21 2000-03-02 Yeda Research And Development Co. Ltd. Anti-inflammatory peptides derived from il-2 and analogues thereof
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
JP3820105B2 (ja) 1998-10-23 2006-09-13 キリン−アムジエン・インコーポレーテツド Ｍｐ１受容体に結合し血小板生成活性を有する二量体トロンボポエチンペプチド模倣体
US7488590B2 (en) * 1998-10-23 2009-02-10 Amgen Inc. Modified peptides as therapeutic agents
WO2000047740A2 (en) 1999-02-12 2000-08-17 Amgen Inc. Tnf-related proteins
US6635646B1 (en) * 1999-05-04 2003-10-21 Schering Corporation Pegylated interferon alfa-CCR5 antagonist combination HIV therapy
JP2003505020A (ja) 1999-07-02 2003-02-12 ジェネンテック・インコーポレーテッド ペプチドリガンドドメイン及び多量体化ドメインを含む融合ペプチド
US6586398B1 (en) * 2000-04-07 2003-07-01 Amgen, Inc. Chemically modified novel erythropoietin stimulating protein compositions and methods
EP1278778A2 (de) 2000-05-03 2003-01-29 Amgen Inc., Modifizierte peptide, die eine fc-domäne behalten, als therapeutische agenzien
DK1642910T3 (da) 2000-12-05 2012-05-07 Alexion Pharma Inc Rationelt designede atistoffer
US7396917B2 (en) 2000-12-05 2008-07-08 Alexion Pharmaceuticals, Inc. Rationally designed antibodies
AU2002307062A1 (en) 2001-04-02 2002-10-15 Purdue Pharma L.P. Thrombopoietin (tpo) synthebody for stimulation of platelet production
US7205275B2 (en) 2001-10-11 2007-04-17 Amgen Inc. Methods of treatment using specific binding agents of human angiopoietin-2
US7138370B2 (en) 2001-10-11 2006-11-21 Amgen Inc. Specific binding agents of human angiopoietin-2
US7332474B2 (en) * 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
JP2006504406A (ja) 2002-06-28 2006-02-09 セントカー・インコーポレーテツド 哺乳動物のｃｈ１欠失ミメティボディ、組成物、方法および使用
CA2490411A1 (en) 2002-06-28 2004-01-08 Centocor, Inc. Mammalian epo mimetic ch1 deleted mimetibodies, compositions, methods and uses
US6919426B2 (en) 2002-09-19 2005-07-19 Amgen Inc. Peptides and related molecules that modulate nerve growth factor activity
AU2003291689A1 (en) 2002-10-31 2004-05-25 Protein Design Labs, Inc. Stable liquid pharmaceutical formulation of antibodies that are prone to isomerization
CA2510893C (en) 2002-12-20 2012-07-10 Amgen, Inc. Binding agents which inhibit myostatin
HUE032370T2 (en) 2003-08-28 2017-09-28 Janssen Pharmaceuticals Inc Peptides and compounds that bind to thrombopoietin receptors
EP1773400A2 (de) 2004-07-08 2007-04-18 Amgen Inc. Therapeutische peptide
CA2580796C (en) * 2004-09-24 2013-03-26 Amgen Inc. Modified fc molecules having peptides inserted in internal loop regions
JP5517450B2 (ja) 2005-03-10 2014-06-11 バイオンテック アーゲー 二量体または多量体のマイクロタンパク質
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
US20090053242A1 (en) * 2006-01-25 2009-02-26 Amgen Inc. Thrombopoietic compounds
US9283260B2 (en) 2006-04-21 2016-03-15 Amgen Inc. Lyophilized therapeutic peptibody formulations
US7981425B2 (en) * 2006-06-19 2011-07-19 Amgen Inc. Thrombopoietic compounds
US8197642B2 (en) * 2007-07-26 2012-06-12 Nichiha Corporation Inorganic board and method for manufacturing the same
US10534898B2 (en) 2017-01-18 2020-01-14 International Business Machines Corporation Code identification

Also Published As

Publication number Publication date
EP2319928B1 (de) 2013-03-27
RS51237B (sr) 2010-12-31
BRPI9914698B8 (pt) 2021-05-25
MY126795A (en) 2006-10-31
ES2422231T3 (es) 2013-09-09
US20050080014A1 (en) 2005-04-14
WO2000024770A3 (en) 2000-09-14
HK1042114B (zh) 2006-09-29
ME00238B (me) 2011-02-10
CN1325447A (zh) 2001-12-05
SK287737B6 (sk) 2011-08-04
DK1783222T3 (da) 2012-07-09
EP1124961B9 (de) 2010-07-21
SK4962001A3 (en) 2001-12-03
US6835809B1 (en) 2004-12-28
JP4332163B2 (ja) 2009-09-16
BG66190B1 (bg) 2011-12-30
CY1113107T1 (el) 2016-04-13
EP1783222A1 (de) 2007-05-09
PL219605B1 (pl) 2015-06-30
CZ20011287A3 (cs) 2001-10-17
MEP42108A (en) 2011-02-10
US9534032B2 (en) 2017-01-03
TWI250988B (en) 2006-03-11
NZ510529A (en) 2003-10-31
BG110221A (en) 2009-06-30
US20060189531A1 (en) 2006-08-24
EP2319928B9 (de) 2014-04-16
US20120034657A1 (en) 2012-02-09
WO2000024770A9 (en) 2000-10-26
DE69934425T2 (de) 2007-09-27
US8748571B2 (en) 2014-06-10
ES2388341T3 (es) 2012-10-11
JP3820105B2 (ja) 2006-09-13
JP2006230413A (ja) 2006-09-07
US20120208760A1 (en) 2012-08-16
PT1124961E (pt) 2007-02-28
CA2346996A1 (en) 2000-05-04
CZ302155B6 (cs) 2010-11-18
ATE348163T1 (de) 2007-01-15
LU91598I2 (fr) 2009-09-30
EA003998B1 (ru) 2003-12-25
CY1107526T1 (el) 2010-07-28
BG105401A (en) 2003-02-28
CY2009012I2 (el) 2010-07-28
HK1042114A1 (en) 2002-08-02
AU773891C (en) 2005-02-17
EP1124961B1 (de) 2006-12-13
DK2319928T3 (da) 2013-06-24
DE69934425D1 (en) 2007-01-25
IL142023A0 (en) 2002-03-10
HUP0104327A3 (en) 2003-09-29
US20150024431A1 (en) 2015-01-22
NO2012005I2 (no) 2015-02-02
PT2319928E (pt) 2013-06-28
YU24301A (sh) 2005-07-19
AU1223900A (en) 2000-05-15
US8618044B2 (en) 2013-12-31
KR100719202B1 (ko) 2007-05-16
SI1124961T1 (sl) 2007-06-30
ES2279649T3 (es) 2007-08-16
WO2000024770A2 (en) 2000-05-04
NO20011962L (no) 2001-06-21
CN1810832A (zh) 2006-08-02
CN1810832B (zh) 2012-12-12
BG65663B1 (bg) 2009-05-29
CN1250721C (zh) 2006-04-12
CY1114940T1 (el) 2016-12-14
EP2319928A1 (de) 2011-05-11
HK1093075A1 (en) 2007-02-23
US20090186822A1 (en) 2009-07-23
DE122009000039I1 (de) 2009-11-05
BR9914698B1 (pt) 2014-04-29
LTC1124961I2 (lt) 2022-03-25
TWI257394B (en) 2006-07-01
PT1783222E (pt) 2012-07-26
BR9914698A (pt) 2003-01-07
US20070142295A1 (en) 2007-06-21
KR20010099695A (ko) 2001-11-09
AU773891B2 (en) 2004-06-10
CY2009012I1 (el) 2010-07-28
DK1124961T3 (da) 2007-04-10
LU91598I9 (de) 2019-01-03
NL300398I1 (nl) 2009-10-01
US9145450B2 (en) 2015-09-29
PL348041A1 (en) 2002-05-06
FR09C0030I2 (fr) 2010-12-31
HUP0104327A2 (hu) 2002-02-28
EA200100465A1 (ru) 2001-10-22
EP1124961A2 (de) 2001-08-22
US7994117B2 (en) 2011-08-09
AR020934A1 (es) 2002-06-05
SI1783222T1 (en) 2012-09-28
EP1783222B1 (de) 2012-06-06
NO20011962D0 (no) 2001-04-20
HU228582B1 (en) 2013-04-29
FR09C0030I1 (fr) 2009-09-25
SI2319928T1 (sl) 2013-08-30
US8044174B2 (en) 2011-10-25
TW200606175A (en) 2006-02-16
NO2012005I1 (no) 2012-04-02
ZA200102102B (en) 2001-11-15
CA2346996C (en) 2013-11-19
NL300398I2 (nl) 2009-12-01
JP2002536960A (ja) 2002-11-05
LTPA2009006I1 (lt) 2022-03-10

Similar Documents

Publication Publication Date Title
NO331027B1 (no) Forbindelse som bindes til en mpl-reseptor, dimer, polynukleotid, vektor, vertscelle, fremgangsmate for fremstilling av en forbindelse, anvendelse av en forbindelse for fremstilling av et medikament, samt farmasoytisk preparat.
DK0807111T3 (da) Substituerede heterocykliske forbindelser, fremgangsmåde til fremstillingen heraf samt farmaceutiske sammensætninger indeholdende disse
NO305907B1 (no) Forbindelser, forbindelser for bekjempelse av sykdommer, legemidler som endotelinreseptorantagonist, farmasöytiske preparater samt anvendelse av slike forbindelser til fremstilling av legemidler
DZ3191A1 (fr) Composés d'indazole et compositions pharmaceutiques inhibant les protéines kinases, et procédés d'utilisation de ceux-ci.
NO973923L (no) Nye taxoider, deres fremstilling samt farmasöytiske preparater inneholdende forbindelsene
BR9810802B1 (pt) composto, composição farmacêutica, e, processo para a preparação de um composto.
DK1042355T3 (da) 11beta-halogen-7alfa-substituerede estratriener, fremgangsmåde til fremstilling af farmaceutiske præparater, der indeholder disse 11beta-halogen-7alfa-substituerede estratriener, samt deres anvendelse til fremstilling af lægemidler
NO20003179D0 (no) Farmasøytisk sammensetning for Õ antagonisere CCR5 som innbefatter anilid-derivat
TR199800631A3 (tr) Ecza formülasyonu.
NO980273D0 (no) Femleddede heterocykluser med bifenylsulfonylsubstitusjon fremgangsmåte for deres fremstilling, deres anvendelse som medikament eller diagnostikum samt medikament inneholdende forbindelsen
AR028162A1 (es) Disponibilidad controlada de compuestos de formulacion, composiciones y metodos para el lavado que utilizan los mismos.
PT1112266E (pt) 4-amino-2-aril-pirimidinas substituidas, sua preparacao, sua utilizacao e composicoes farmaceuticas que as contem.
BR9906373B1 (pt) compostos pirimidinona, composições farmacêuticas contendo os compostos e processos para a preparação dos mesmos.
NO20003496D0 (no) Nye aromatiske amider, fremgangsmÕte for fremstilling av disse, samt deres anvendelse som medisiner
HK1015789A1 (en) Propanolamine derivatives, processes for their preparation, pharmaceuticals comprising these compounds, and their use.
ZA200102589B (en) Propanolamine derivatives substituted with heterocyclic compounds, methods for their production, pharmaceutical compositions containing said compounds and the use thereof.
DK1140031T3 (da) Farmaceutisk sammensætning til kontrolleret frigivelse med tilidinmesylat som aktivt stof
IT1311921B1 (it) Composti farmaceutici.
NO960364L (no) Basisk-substituerte benzolguanidiner, fremgangsmåte for fremstilling derav, deres anvendelse som medikament eller diagnostikum samt medikament inneholdende forbindelsen
NO20022801D0 (no) Substituerte norbornylaminoderivater, fremgangsmåte for deres fremstilling, deres anvendelse som medikament eller diagnostikumsåvel som medikamenter inneholdende disse
DK0755919T3 (da) Substituerede kanelsyreguanidider, fremgangsmåde til deres fremstilling, deres anvendelse som hjerte-kredsløbs-medikament e
NO972433D0 (no) Substituerte 2-naftoylguanidiner, fremgangsmåter for deres fremstilling, deres anvendelse som medikament eller diagnostikum samt medikamenter inneholdende forbindelsene
HK1045684A1 (en) Biphenyl derivatives as antagonists of the neurokinine-1 receptor.
NO974563D0 (no) Nye taxoider, deres fremstilling samt farmasöytiske preparater inneholdende forbindelsene
TR199800403A3 (tr) a-Bromo-laktam türevlerinin hazirlanmasi için yöntem.

Legal Events

Date Code Title Description
SPCF Filing of supplementary protection certificate

Free format text: PRODUCT NAME: NPLATE (2 FORSKJELLIGE PREPARATVARIANTER); NAT. REG. NO/DATE: EU/1/08/497/001/NO 20090204; FIRST REG. NO/DATE: EU/1/08/497/001/NO 20090204

Spc suppl protection certif: 2012005

Filing date: 20120312

SPCG Granted supplementary protection certificate

Free format text: PRODUCT NAME: NPLATE (2 FORSKJELLIGE PREPARATVARIANTER); NAT. REG. NO/DATE: EU/1/08/497/001/NO 20090204; FIRST REG. NO/DATE: EU/1/08/497/001/NO 20090204

Spc suppl protection certif: 2012005

Filing date: 20120312

Extension date: 20240204

MK1K Patent expired
SPCX Expiry of an spc

Spc suppl protection certif: 2012015