NO329751B1 - Inhibitorer for serin-proteaser, spesielt hepatitt - C - virus NS3-protease - Google Patents

Inhibitorer for serin-proteaser, spesielt hepatitt - C - virus NS3-protease Download PDF

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Publication number
NO329751B1
NO329751B1 NO19991832A NO991832A NO329751B1 NO 329751 B1 NO329751 B1 NO 329751B1 NO 19991832 A NO19991832 A NO 19991832A NO 991832 A NO991832 A NO 991832A NO 329751 B1 NO329751 B1 NO 329751B1
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NO
Norway
Prior art keywords
compound according
term
alkyl
aryl
cycloalkyl
Prior art date
Application number
NO19991832A
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English (en)
Norwegian (no)
Other versions
NO991832D0 (no
NO991832L (no
Inventor
Roger D Tung
Mark A Murcko
Govinda Rao Bhisetti
David D Deininger
Scott L Harbeson
Luc J Farmer
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of NO991832D0 publication Critical patent/NO991832D0/no
Publication of NO991832L publication Critical patent/NO991832L/no
Priority to NO20100145A priority Critical patent/NO20100145L/no
Publication of NO329751B1 publication Critical patent/NO329751B1/no

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1024Tetrapeptides with the first amino acid being heterocyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1027Tetrapeptides containing heteroatoms different from O, S, or N
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02Linear peptides containing at least one abnormal peptide link
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
NO19991832A 1996-10-18 1999-04-16 Inhibitorer for serin-proteaser, spesielt hepatitt - C - virus NS3-protease NO329751B1 (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO20100145A NO20100145L (no) 1996-10-18 2010-01-29 Forbindelser med serin-protease-inhiberende virkning, spesielt hepatitt C-NS3-inhiberende virkning

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2829096P 1996-10-18 1996-10-18
PCT/US1997/018968 WO1998017679A1 (en) 1996-10-18 1997-10-17 Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease

Publications (3)

Publication Number Publication Date
NO991832D0 NO991832D0 (no) 1999-04-16
NO991832L NO991832L (no) 1999-06-17
NO329751B1 true NO329751B1 (no) 2010-12-13

Family

ID=21842625

Family Applications (2)

Application Number Title Priority Date Filing Date
NO19991832A NO329751B1 (no) 1996-10-18 1999-04-16 Inhibitorer for serin-proteaser, spesielt hepatitt - C - virus NS3-protease
NO20100145A NO20100145L (no) 1996-10-18 2010-01-29 Forbindelser med serin-protease-inhiberende virkning, spesielt hepatitt C-NS3-inhiberende virkning

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20100145A NO20100145L (no) 1996-10-18 2010-01-29 Forbindelser med serin-protease-inhiberende virkning, spesielt hepatitt C-NS3-inhiberende virkning

Country Status (33)

Country Link
US (5) US6265380B1 (h)
EP (3) EP0932617B1 (h)
JP (3) JP4080541B2 (h)
KR (1) KR100509388B1 (h)
CN (1) CN1133649C (h)
AP (1) AP1019A (h)
AT (1) ATE212037T1 (h)
BG (1) BG103392A (h)
BR (1) BR9712544B1 (h)
CA (1) CA2268391A1 (h)
CZ (1) CZ298749B6 (h)
DE (1) DE69709671T2 (h)
DK (1) DK0932617T3 (h)
EA (1) EA001915B1 (h)
EE (1) EE04023B1 (h)
ES (1) ES2169880T3 (h)
GE (1) GEP20012471B (h)
HU (1) HU227742B1 (h)
ID (1) ID21649A (h)
IL (3) IL129407A0 (h)
IN (1) IN183120B (h)
IS (1) IS5028A (h)
MX (1) MXPA05003026A (h)
NO (2) NO329751B1 (h)
NZ (1) NZ335276A (h)
PL (2) PL194025B1 (h)
PT (1) PT932617E (h)
SK (1) SK286105B6 (h)
TR (1) TR199901602T2 (h)
TW (1) TW530065B (h)
UA (2) UA66767C2 (h)
WO (1) WO1998017679A1 (h)
ZA (1) ZA979327B (h)

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