NO318784B1 - Pyrrolo(2,3-d)pyrimidinforbindelser samt anvendelse derav og farmasoytisk sammensetning - Google Patents
Pyrrolo(2,3-d)pyrimidinforbindelser samt anvendelse derav og farmasoytisk sammensetning Download PDFInfo
- Publication number
- NO318784B1 NO318784B1 NO20006453A NO20006453A NO318784B1 NO 318784 B1 NO318784 B1 NO 318784B1 NO 20006453 A NO20006453 A NO 20006453A NO 20006453 A NO20006453 A NO 20006453A NO 318784 B1 NO318784 B1 NO 318784B1
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- methyl
- pyrrolo
- lrms
- hydroxy
- Prior art date
Links
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- 150000004943 pyrrolo[2,3-d]pyrimidines Chemical class 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims description 103
- 150000003839 salts Chemical class 0.000 claims description 40
- 108010019421 Janus Kinase 3 Proteins 0.000 claims description 33
- 102000006500 Janus Kinase 3 Human genes 0.000 claims description 33
- 125000000217 alkyl group Chemical group 0.000 claims description 25
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N EtOH Substances CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 15
- 241000124008 Mammalia Species 0.000 claims description 14
- 239000003795 chemical substances by application Substances 0.000 claims description 14
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 14
- 208000035475 disorder Diseases 0.000 claims description 14
- 239000001257 hydrogen Substances 0.000 claims description 14
- 229910052739 hydrogen Inorganic materials 0.000 claims description 14
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 13
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- 229910052736 halogen Inorganic materials 0.000 claims description 9
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- 238000002360 preparation method Methods 0.000 claims description 7
- 125000003342 alkenyl group Chemical group 0.000 claims description 6
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 5
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- 125000000041 C6-C10 aryl group Chemical group 0.000 claims description 4
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- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 4
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims description 3
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- 201000004624 Dermatitis Diseases 0.000 claims description 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 2
- RVXVIKRNUXPSPD-OWYJLGKBSA-N n-methyl-n-[(5s)-2-methyl-5-prop-1-en-2-ylcyclohexyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine Chemical compound CC1CC[C@H](C(C)=C)CC1N(C)C1=NC=NC2=C1C=CN2 RVXVIKRNUXPSPD-OWYJLGKBSA-N 0.000 claims description 2
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Classifications
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- Hematology (AREA)
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- Pain & Pain Management (AREA)
- Transplantation (AREA)
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- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8986698P | 1998-06-19 | 1998-06-19 | |
US10478798P | 1998-10-19 | 1998-10-19 | |
PCT/IB1999/001100 WO1999065908A1 (en) | 1998-06-19 | 1999-06-14 | PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS |
Publications (3)
Publication Number | Publication Date |
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NO20006453D0 NO20006453D0 (no) | 2000-12-18 |
NO20006453L NO20006453L (no) | 2001-02-05 |
NO318784B1 true NO318784B1 (no) | 2005-05-09 |
Family
ID=26781018
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20006453A NO318784B1 (no) | 1998-06-19 | 2000-12-18 | Pyrrolo(2,3-d)pyrimidinforbindelser samt anvendelse derav og farmasoytisk sammensetning |
Country Status (41)
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US (3) | US6610847B2 (fi) |
EP (1) | EP1087970B1 (fi) |
JP (3) | JP4666762B2 (fi) |
KR (1) | KR100415791B1 (fi) |
CN (1) | CN1128800C (fi) |
AP (1) | AP1021A (fi) |
AR (1) | AR016499A1 (fi) |
AT (1) | ATE265458T1 (fi) |
AU (1) | AU3951899A (fi) |
BG (1) | BG65119B1 (fi) |
BR (1) | BR9911365A (fi) |
CA (1) | CA2335492C (fi) |
CZ (1) | CZ20004727A3 (fi) |
DE (1) | DE69916833T2 (fi) |
DK (1) | DK1087970T3 (fi) |
EA (1) | EA005852B1 (fi) |
ES (1) | ES2219018T3 (fi) |
FR (1) | FR14C0019I2 (fi) |
GE (1) | GEP20074227B (fi) |
GT (1) | GT199900090A (fi) |
HK (1) | HK1036801A1 (fi) |
HR (1) | HRP20000885B1 (fi) |
HU (1) | HUP0102574A3 (fi) |
ID (1) | ID26698A (fi) |
IL (1) | IL139586A0 (fi) |
MA (1) | MA26654A1 (fi) |
MY (1) | MY125916A (fi) |
NO (1) | NO318784B1 (fi) |
NZ (1) | NZ518444A (fi) |
OA (1) | OA11572A (fi) |
PA (1) | PA8476001A1 (fi) |
PE (1) | PE20000698A1 (fi) |
PL (1) | PL198640B1 (fi) |
PT (1) | PT1087970E (fi) |
RS (1) | RS50087B (fi) |
SA (1) | SA99200283B1 (fi) |
SK (1) | SK286640B6 (fi) |
TN (1) | TNSN99126A1 (fi) |
TR (1) | TR200003719T2 (fi) |
TW (1) | TW505646B (fi) |
WO (1) | WO1999065908A1 (fi) |
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PA8474101A1 (es) | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
PT1087970E (pt) * | 1998-06-19 | 2004-06-30 | Pfizer Prod Inc | Compostos pirrolo¬2,3-d|pirimidina |
NZ518884A (en) | 1999-12-10 | 2004-02-27 | Pfizer Prod Inc | Pyrrolo[2,3-d]pyrimidine compounds |
AU784297C (en) | 2000-06-26 | 2007-01-11 | Pfizer Products Inc. | Pyrrolo(2,3-d)pyrimidine compounds as immunosuppressive agents |
BR0114020A (pt) | 2000-09-20 | 2003-07-22 | Merck Patent Gmbh | 4-amino-quinazolinas |
US7067550B2 (en) * | 2000-11-03 | 2006-06-27 | Massachusetts Institute Of Technology | Treatments for neurotoxicity in Alzheimer's Disease |
DE10063294A1 (de) * | 2000-12-19 | 2002-07-04 | Aventis Pharma Gmbh | Substituierte Heterocyclo-Norbornylamino-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
US20040102455A1 (en) * | 2001-01-30 | 2004-05-27 | Burns Christopher John | Method of inhibiting kinases |
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EP1401415B1 (en) | 2001-06-29 | 2006-06-21 | AB Science | Use of n-phenyl-2-pyrimidine-amine derivatives for treating inflammatory diseases |
JP2004537542A (ja) * | 2001-06-29 | 2004-12-16 | アブ サイエンス | 炎症性腸疾患(ibd)を治療するための、チロシンキナーゼ阻害剤の使用 |
CA2452368A1 (en) | 2001-06-29 | 2003-01-09 | Ab Science | New potent, selective and non toxic c-kit inhibitors |
DK1401413T3 (da) | 2001-06-29 | 2007-03-26 | Ab Science | Anvendelse af tyrosinkinaseinhibitorer til behandling af allergiske sygdomme |
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US7829566B2 (en) | 2001-09-17 | 2010-11-09 | Werner Mederski | 4-amino-quinazolines |
GT200200234A (es) | 2001-12-06 | 2003-06-27 | Compuestos cristalinos novedosos | |
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EP1388541A1 (en) * | 2002-08-09 | 2004-02-11 | Centre National De La Recherche Scientifique (Cnrs) | Pyrrolopyrazines as kinase inhibitors |
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JP2007512316A (ja) * | 2003-11-25 | 2007-05-17 | ファイザー・プロダクツ・インク | アテローム性動脈硬化症の治療方法 |
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