KR920702359A - 치료용 헤테로사이클 화합물 - Google Patents

치료용 헤테로사이클 화합물

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KR920702359A
KR920702359A KR1019920700284A KR920700284A KR920702359A KR 920702359 A KR920702359 A KR 920702359A KR 1019920700284 A KR1019920700284 A KR 1019920700284A KR 920700284 A KR920700284 A KR 920700284A KR 920702359 A KR920702359 A KR 920702359A
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알란 던칸 로버트슨
알란 피터 힐
로버트 챠알스 글렌
그림 리챠드 마틴
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원본미기재
더 웰컴 화운데이션 리미티드
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Priority claimed from GB919102182A external-priority patent/GB9102182D0/en
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    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Steroid Compounds (AREA)

Abstract

내용 없음

Description

치료용 헤테로사이클 화합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (19)

  1. 하기 일반식(Ⅰ)의 화합물 및 이것의 염, 용매화합물 및 생리적 작용성 유도체 :
    상기식에서, n은 0내지 3의 정수이고: w은 다음 일반식 (ⅰ), (ⅱ) 또는 (ⅲ)의 그룹이고,
    여기에서, R은 C1-4알킬이고, X는 -O-, -S-, -NH-, 또는 -CH2-이고, Y는 산소 또는 황이고 일반식 (ⅰ) 또는 (ⅱ)에서의 비대칭 중심 *은 그것의 (S) 또는 (R)형태이거나 또는 이들의 어떠한 비율의 혼합물이고, 및 Z는 다음 일반식 (ⅳ), (ⅴ) 또는 (ⅳ)의 그룹이고,
    여기서, R1및 R2는 각각 수소 및 C1-4알킬로 부터 선택되고 R3는 수소 또는 C1-4알킬이다.
  2. 제1항에 있어서, n이 1이거나, 또는 W이 일반식 (ⅰ)의 그룹이거나, 또는 Z가 일반식 (ⅳ) 또는 (ⅳ)의 그룹인 일반식 (Ⅰ)의 화합물 및 이것의 생리학적으로 허용가능한 염, 용매화물 및 생리적 작용성 유도체.
  3. 제1항에 있어서, n이 1이고, W은 R이 수소이고, X가 -O-이고 Y가 산소인 일반식 (ⅰ)의 그룹이고, 및 Z는 R1=R2=수소 또는 메틸인 일반식 (ⅳ) 또는 (ⅵ)의 그룹인 일반식 (Ⅰ)의 화합물 및 이것의 생리학적으로 허용가능한 염, 용매화물 및 생리적 작용성 유도체.
  4. 제1항에 있어서, (S) 또는 (R)의 형태 또는 이들의 어떠한 비율의 혼합물로서 N,N-디메틸-2-[5-(2-옥소-1,3-옥사졸리딘-4-일메틸)-1H-인돌-3-일]에틸아민 또는 ;3-(1-메틸-4-피페리딜)-5-(2-옥소-1,3-옥사졸리딘-4-일메틸)-1H-인돌, 또는 이것의 생리학적으로 허용가능한 염, 용매화물 및 생리적 작용성 유도체인 일반식(Ⅰ)의 화합물.
  5. 제4항에 있어서, (S)-N,N-디메틸-2-[5-(2-옥소-1,3-옥사졸리딘-4-일메틸)-1H-인돌-3-일]에틸아민 또는 이것의 생리학적으로 허용가능한 염, 용매화물 및 생리적 작용성 유도체인 일반식(Ⅰ)의 화합물.
  6. 치료제로서 사용하기위한 제1내지 5항중 어느 한항에 따른 일반식 (Ⅰ)의 화합물, 이것의 생리학적으로 허용가능한 염, 용매화물, 또는 생리학적 작용성 유도체.
  7. "5-HT-라이크" 수용체 동근이 나타내어지는 임상학적 상태의 예방 또는 치료에 사용하기 위한, 제1내지 5항중 어느 한항에 따른 일반식(Ⅰ)의 화합물, 이것의 생리학적으로 허용가능한 염, 용매화합물 또는 생리학적 작용성 유도체.
  8. 편두통의 예방 또는 치료에 사용하기 위한 제1 내지 5항중 어느 한항에 따른 일반식(Ⅰ)의 화합물, 이것의 생리학적으로 허용가능한 염, 용매화물 또는 생리학적 작용성 유도체.
  9. "5-HT-라이크" 수용체 동근이 나타내어지는 임상학적 상태의 예방 또는 치료용 약물의 제조시에 제1내지 제5항중 어느 한항에 따른 일반식(Ⅰ)의 화합물, 이것의 생리학적으로 허용가능한 염, 용매화물 또는 생리학적 작용성 유도체를 사용하는 방법.
  10. 편두통의 예방 또는 치료용 약물의 제조시에 제1 내지 5항중 어느 한항에 따른 일반식(Ⅰ)의 화합물, 또는 이것의 생리학적으로 허용 가능한 염, 용매화물, 또는 생리학적 작용성 유도체를 사용하는 방법.
  11. 치료학적으로 유효량의 제1 내지 5항중 어느 한항에 따른 일반식(Ⅰ)화합물, 또는 이것의 생리학적으로 허용가능한 염, 용매화물 또는 생리학적 작용성 유도체를 포유동물에게 투여하는 것을 포함하는 포유류에서 임상학적 상태의 예방 또는 치료방법.
  12. 제11항에 있어서, "5-HT-라이크" 수용체 동근이 나타내어지는 임상학적 상태의 예방 또는 치료방법.
  13. 제12항에 있어서, 편두통의 예방 또는 치료방법.
  14. 제11내지 제13항중 어느 한항에 있어서, 포유동물이 사람인 방법.
  15. 제1내지 제5항중 어느 한항에 따른 일반식(Ⅰ)의 화합물 또는 이것의 생리학적으로 허용가능한 염, 용매화물 또는 생리학적 작용성 유도체, 제약학적으로 허용가능한 담체 및 임의적으로 하나 이상의 다른 생리학적 활성성분을 포함하는 약물.
  16. 제15항에 있어서, 정제 또는 캡슐의 형태인 약품.
  17. (a)Z가 하기 일반식(ⅳ)의 그룹인 경우, 하기 일반식(Ⅱ)의 화합물을, 하기 일반식(Ⅲ)의 화합물 또는 이것의 카르보닐-보호된 형태와 반응시키고, (b)Z가 하기 일반식(Ⅴ)의 구룹인 경우, 일반식(ⅩⅩⅩⅠ)의 화합물을 하기 일반식(ⅩⅩⅧ)의 화합물과 반응시키고, 그리고 (c)Z가 하기 일반식(ⅵ)의그룹인 경우, 일반식(Ⅰ)의 화합물을 환원시키고, W이 하기 일반식(ⅰ) 또는 (ⅱ)의 그룹인 경우에는 하기 일반식(ⅩⅤ) 또는 (ⅩⅩⅤ)의 화합무을 하기 일반식 (Ⅶ)의 화합물과 반응시키고, 임의적으로 이렇게 형성된 일반식(Ⅰ)의 화합물을 대응 하는 염, 용매화물, 생리학적 작용성 유도체로 전환시킴을 포함하는, 하기 일반식(Ⅰ)의 화합물의 제조방법 :
    상기식에서, n은 0내지 13의 정수이고, W은 다음 일반식 (ⅰ), (ⅱ) 또는 (ⅲ)의 그룹이고,
    여기에서, R은 수소 또는 C1-4알킬이고, X는 -O-, -S-, -NH-, 또는 -CH2-이고, Y는 산소 또는 황이고 일반식(ⅰ) 또는 (ⅱ)에서의 비대칭 중심 *은 (S) 또는 (R)형태 도는 이들의 어떠한 비율의 혼합물이고, 및 Z는 하기 일반식 (ⅳ), (ⅴ) 또는 (ⅳ)의 그룹이고,
    여기서, R1및 R2는 각각 수소 및 C1-4알킬로 부터 선택되고 R3는 수소 또는 C1-4이고, L은, 아미노기 또는 -NR1R2로 현장에서 전환될수 있는 적당한 이탈기 또는 보호된 아미노기 이고, 동일 또는 상이할수 있는 L 및 L1은 적당한 이탈기이다.
  18. (a)일반식 (Ⅰ)의 화합물 또는 이것의 생리학적으로 허용가능한 염, 용매화합물, 또는 생리학적 작용성 유도체를 제17항의 방법에 의해 제조하고, (b)단계 (a)로 부터의 생성물을 제약학적으로 허용가능한 담체 및 임의적으로는 하나 이상의 다른 생리학적 활성성분과 혼합함을 포함하는 약물의 제조방법.
  19. 제18항에 있어서, 단계 (b)로 부터의 혼합물을 정제 또는 캡슐로 형성하는 추가의 단계(c)를 포함하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920700284A 1990-06-07 1991-06-06 치료용 헤테로사이클 화합물 KR100215627B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB9012672-3 1990-06-07
GB909012672A GB9012672D0 (en) 1990-06-07 1990-06-07 Therapeutic heterocyclic compounds
GB9012672.3 1990-06-07
GB919102182A GB9102182D0 (en) 1991-02-01 1991-02-01 Therapeutic heterocyclic compounds
GB9102182-4 1991-02-01
PCT/GB1991/000908 WO1991018897A1 (en) 1990-06-07 1991-06-06 Therapeutic heterocyclic compounds

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KR920702359A true KR920702359A (ko) 1992-09-03
KR100215627B1 KR100215627B1 (ko) 1999-08-16

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Families Citing this family (123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ283018B6 (cs) * 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
TW263508B (ko) * 1991-02-12 1995-11-21 Pfizer
KR0184911B1 (ko) * 1991-11-25 1999-05-01 알렌 제이. 스피겔 인돌유도체
GB9201038D0 (en) * 1992-01-16 1992-03-11 Glaxo Group Ltd Chemical compounds
TW288010B (ko) * 1992-03-05 1996-10-11 Pfizer
EP0630374B1 (en) * 1992-03-13 2001-09-05 MERCK SHARP & DOHME LTD. Imidazole, triazole and tetrazole derivatives
GB9207396D0 (en) * 1992-04-03 1992-05-13 Merck Sharp & Dohme Therapeutic agents
US6380233B1 (en) 1992-04-07 2002-04-30 Pfizer Inc Indole derivatives as 5-HT1 agonists
JP2644088B2 (ja) 1992-04-07 1997-08-25 フアイザー・インコーポレイテツド ５−ｈｔ１作動薬としてのインドール誘導体
NZ251047A (en) * 1992-04-10 1996-09-25 Pfizer Acylaminoindole derivatives and medicaments
GB9207930D0 (en) * 1992-04-10 1992-05-27 Pfizer Ltd Indoles
GB9208161D0 (en) * 1992-04-14 1992-05-27 Pfizer Ltd Indoles
GB9208463D0 (en) * 1992-04-16 1992-06-03 Merck Sharp & Dohme Therapeutic agents
GB9209882D0 (en) * 1992-05-07 1992-06-24 Glaxo Lab Sa Compositions
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
AU672802B2 (en) * 1992-07-24 1996-10-17 Merck Sharp & Dohme Limited Imidazole, triazole and tetrazole derivatives
GB9216009D0 (en) * 1992-07-28 1992-09-09 Almirall Lab New indol derivatives
IL106445A (en) * 1992-07-30 1998-01-04 Merck Sharp & Dohme History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them
ES2056025B1 (es) * 1992-10-08 1995-05-01 Almirall Lab Nuevos derivados de indol.
TW251284B (ko) * 1992-11-02 1995-07-11 Pfizer
GB9226532D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
FR2701026B1 (fr) * 1993-02-02 1995-03-31 Adir Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
ES2070087B1 (es) * 1993-08-13 1996-02-16 Pfizer Derivados de indol
AU686654B2 (en) * 1993-08-31 1998-02-12 Pfizer Inc. 5-arylindole derivatives
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
US6423731B2 (en) * 1994-01-06 2002-07-23 Zeneca Limited Indole derivatives as prodrugs of 5-HT1-like receptor agonists
GB9401436D0 (en) * 1994-01-26 1994-03-23 Wellcome Found Therapeutic heterocyclic compounds
US5807857A (en) * 1994-05-19 1998-09-15 Merck Sharp & Dohme Ltd. Piperazine, piperidine and tetrahydropyridine derivative of indol-3-alkyl as 5-HT1D-α agonists
AU2621995A (en) * 1994-06-01 1995-12-21 Zeneca Limited Indole derivatives as prodrugs of 5-ht1-like receptor agonists
WO1996003400A1 (en) * 1994-07-26 1996-02-08 Pfizer Inc. 4-indole derivatives as serotonin agonists and antagonists
US5521196A (en) * 1994-10-05 1996-05-28 Eli Lilly And Company 5-HT1F agonists for the treatment of migraine
GB9423682D0 (en) * 1994-11-23 1995-01-11 Merck Sharp & Dohme Therapeutic agents
US5521197A (en) * 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
EP0796258A1 (en) * 1994-12-06 1997-09-24 MERCK SHARP &amp; DOHME LTD. Azetidine, pyrrolidine and piperidine derivatives as 5ht1 receptor agonists
DE4443892A1 (de) * 1994-12-09 1996-06-13 Bayer Ag 4-(Chinolin-2-yl-methoxy)-phenyl-essigsäurederivate
GB9501865D0 (en) * 1995-01-31 1995-03-22 Merck Sharp & Dohme Therapeutic agents
TR199700993T1 (xx) * 1995-03-20 1998-03-21 Eli Lilly And Company 5-ikameli-3-(1,2,3,6-tetrahidropridin-4-il)- ve 3-(piperidin-4-il)-1H-indoller: yeni 5-HT1F agonistler.
GB9515060D0 (en) * 1995-07-22 1995-09-20 Wellcome Found Therapeutic heterocyclic compounds
GB9515305D0 (en) * 1995-07-26 1995-09-20 Wellcome Found Therapeutic heterocyclic compounds
GB9516145D0 (en) * 1995-08-07 1995-10-04 Wellcome Found Improved chemical synthesis
US6909005B1 (en) 1995-08-07 2005-06-21 Astrazeneca Uk Limited One post synthesis of 2-oxazolidinone derivatives
GB9516143D0 (en) * 1995-08-07 1995-10-04 Wellcome Found Improved chemical synthesis
US5942536A (en) * 1995-10-10 1999-08-24 Eli Lilly And Company N- 2-substituted-3-(2-aminoethyl)-1H-indol-5-YL!-Amides: new 5-HT1F agonists
US5998415A (en) * 1995-11-02 1999-12-07 Merck Sharp & Dohme Ltd. Bicyclic heteroaryl-alkylene-(homo)piperazinones and thione analogues thereof, their preparation, and their use of as selective agonists of 5-HT1 -like receptors
GB9609374D0 (en) * 1996-05-03 1996-07-10 Merck Sharp & Dohme Therapeutic agents
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
GB9706089D0 (en) * 1997-03-24 1997-05-14 Scherer Ltd R P Pharmaceutical composition
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
AR017200A1 (es) 1997-12-23 2001-08-22 Astrazeneca Ab Compuestos inhibidores de la proteina cinasa c, sales farmaceuticamente aceptables de los mismos, formulaciones farmaceuitcas que los comprenden, usode las mismas y proceso para la sintesis de dichos compuestos
SE9800835D0 (sv) 1998-03-13 1998-03-13 Astra Ab New Compounds
WO2000000490A2 (en) * 1998-06-26 2000-01-06 Eli Lilly And Company 5-ht1f agonists
US6492406B1 (en) 1999-05-21 2002-12-10 Astrazeneca Ab Pharmaceutically active compounds
US6346625B1 (en) * 1999-06-23 2002-02-12 Astrazeneca Ab Protein kinase inhibitors
GB9928578D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Pharmaceutical formulations
EP1341777B1 (en) * 2000-11-29 2007-09-26 Eli Lilly And Company 1-(2-m-methanesulfonamidophenylethyl)-4-(m-trifluoromethylphenyl)piperazine and pharmaceutically acceptable salts and solvates thereof and their use in the treatement of incontinence
US7458374B2 (en) * 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US7766013B2 (en) * 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7090830B2 (en) * 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
EP1435945B1 (en) * 2001-06-05 2008-08-13 Aung-din, Ronald Topical migraine therapy
US8329734B2 (en) 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
CN1649614A (zh) 2002-02-22 2005-08-03 新河药品股份有限公司 活性剂传递系统和保护及施用活性剂的方法
AU2003249582B2 (en) 2002-06-21 2006-08-03 Suven Life Sciences Limited Tetracyclic arylsulfonyl indoles having serotonin receptor affinity
BR0312175A (pt) 2002-06-21 2005-04-05 Suven Life Sciences Ltd Composto, composição farmacêutica, uso de um composto, método para o tratamento e método para reduzir a morbidez e a mortalidade associadas com o excesso de peso
ES2204302B2 (es) * 2002-08-07 2005-03-01 Laboratorios Vita, S.A. Procedimiento para la obtencion de un compuesto farmaceuticamente activo.
US20040105818A1 (en) * 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) * 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
KR100776118B1 (ko) 2002-11-28 2007-11-15 수벤 라이프 사이언시스 리미티드 엔-아릴술포닐-3-아미노알콕시인돌
ES2310243T3 (es) 2002-11-28 2009-01-01 Suven Life Sciences Limited Indoles n-aril-3-sulfonil sustituidos que tienen afinidad por receptores de serotonina, proceso para su preparacion y composicion farmaceutica que los contiene.
JP4571507B2 (ja) 2002-12-18 2010-10-27 スベン ライフ サイエンシズ リミティド セロトニン受容体親和性を有する四環系３−置換インドール
EP1572647B1 (en) 2002-12-20 2016-09-21 Basf Se Synthesis of amines and intermediates for the synthesis thereof
WO2004063175A1 (en) * 2003-01-13 2004-07-29 Natco Pharma Limited A novel and an improved process for the preparation of (s)-4-(4-aminobenzyl)-2- oxazolidinone
GB0302094D0 (en) 2003-01-29 2003-02-26 Pharmagene Lab Ltd EP4 receptor antagonists
US20040192958A1 (en) * 2003-03-25 2004-09-30 Hyatt John Anthony Process for preparing derivatives of 4-halobutyraldehyde
WO2004104490A1 (en) 2003-05-21 2004-12-02 Alexza Pharmaceuticals, Inc. Self-contained heating unit and drug-supply unit employing same
AR044688A1 (es) * 2003-06-12 2005-09-21 Euro Celtique Sa Agentes terapeuticos utiles para el tratamiento del dolor
WO2004112723A2 (en) 2003-06-20 2004-12-29 Ronald Aung-Din Tropical therapy for the treatment of migraines, muscle sprains, muscle spasm, spasticity and related conditions
CN1829708A (zh) * 2003-07-24 2006-09-06 尤罗塞尔蒂克股份有限公司 哌啶化合物和含有它们的药物组合物
GB0324269D0 (en) 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
EP1711493A2 (en) * 2004-02-06 2006-10-18 CIBA SPECIALTY CHEMICALS HOLDING INC. Patent Departement Crystalline forms of zolmitriptan
US7540286B2 (en) * 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
WO2006022714A1 (en) * 2004-08-12 2006-03-02 Alexza Pharmaceuticals, Inc. Aerosol drug delivery device incorporating percussively activated heat packages
WO2006055964A2 (en) * 2004-11-19 2006-05-26 Teva Pharmaceutical Industries Ltd. Zolmitriptan crystal forms
US7375219B2 (en) * 2005-04-13 2008-05-20 Neuraxon, Inc. Substituted indole compounds having NOS inhibitory activity
WO2007083320A2 (en) 2006-01-19 2007-07-26 Matrix Laboratories Ltd Conversion of aromatic diazonium salt to aryl hydrazine
TW200808780A (en) 2006-04-13 2008-02-16 Neuraxon Inc 1,5 and 3,6- substituted indole compounds having NOS inhibitory activity
WO2008018090A2 (en) * 2006-08-09 2008-02-14 Matrix Laboratories Ltd An improved process for the preparation of zolmitriptan
CA2666149A1 (en) * 2006-10-19 2008-04-24 Auspex Pharmaceuticals, Inc. Substituted indoles
ES2691033T3 (es) 2007-02-11 2018-11-23 Map Pharmaceuticals Inc. Método de administración terapéutica de DHE para activar el alivio rápido de la migraña a la vez que se reduce al mínimo el perfil de los efectos secundarios
CZ2007158A3 (cs) * 2007-02-26 2008-10-22 Zentiva, A. S. Zpusob prípravy zolmitriptanu
WO2008112661A2 (en) 2007-03-09 2008-09-18 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
NZ579820A (en) * 2007-04-27 2011-01-28 Purdue Pharma Lp Therapeutic agents useful for treating pain
PT2142529E (pt) * 2007-04-27 2014-03-20 Purdue Pharma Lp Antagonistas de trpv1 e as respectivas utilizações
CA2701414A1 (en) * 2007-10-03 2009-04-09 Generics [Uk] Limited Process for the preparation of zolmitriptan, salts and solvates thereof
WO2009064505A1 (en) * 2007-11-16 2009-05-22 The Arizona Board Of Regents On Behalf Of The University Of Arizona Methods for treating visceral pain
US20090131503A1 (en) * 2007-11-16 2009-05-21 Annedi Subhash C 3,5 - substituted indole compounds having nos and norepinephrine reuptake inhibitory activity
BRPI0820632A2 (pt) * 2007-11-16 2015-06-16 Neuraxon Inc Compostos de indol e métodos para tratamento de dor visceral
CN101181267B (zh) * 2007-11-30 2010-09-08 重庆医科大学医药研究所 佐米曲普坦舌下片
KR101517415B1 (ko) * 2008-05-14 2015-05-07 에스케이바이오팜 주식회사 난용성 항경련제를 함유하는 경비 항경련성 약학 조성물
AU2009269129B2 (en) 2008-06-30 2015-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy
US20100217013A1 (en) * 2008-12-15 2010-08-26 Wenge Li Enantioselective process for the preparation of zolmitriptan
WO2010151804A1 (en) * 2009-06-26 2010-12-29 Map Pharmaceuticals, Inc. Administration of dihydroergotamine mesylate particles using a metered dose inhaler
US20110038928A1 (en) * 2009-08-12 2011-02-17 Glenmark Generics Ltd Orally disintegrating tablets of zolmitriptan
HUE031661T2 (en) 2010-10-15 2017-07-28 Contera Pharma Aps Combinations of serotonin receptor agonists for the treatment of movement disorders
SG195136A1 (en) 2011-06-22 2013-12-30 Purdue Pharma Lp Trpv1 antagonists including dihydroxy substituent and uses thereof
PL2734634T3 (pl) 2011-07-22 2020-03-31 The University Of Chicago Igf-1 do zastosowania do leczenia migreny
US9006453B2 (en) 2011-09-02 2015-04-14 Emcure Pharmaceuticals Limited Process for preparation of zolmitriptan
US10561618B2 (en) 2012-04-18 2020-02-18 Contera Pharma Aps Orally available pharmaceutical formulation suitable for improved management of movement disorders
AU2013361337A1 (en) 2012-12-21 2015-07-09 Map Pharmaceuticals, Inc. 8'-Hydroxy-Dihydroergotamine compounds and compositions
CN107530318A (zh) 2015-03-02 2018-01-02 阿福金制药有限责任公司 用大麻素的局部区域神经影响性疗法
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
WO2017122161A1 (en) 2016-01-15 2017-07-20 Cadila Healthcare Limited An intranasal composition comprising 5ht1b/1d receptor agonists
EP3407869A1 (en) 2016-01-27 2018-12-05 Instar Technologies A.S. Oromucosal nanofiber carriers for therapeutic treatment
CN109689036A (zh) 2016-07-11 2019-04-26 康特拉医药公司 用于治疗早晨运动不能的脉冲药物输送系统
US20180049994A1 (en) 2016-08-16 2018-02-22 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene
JP2022536773A (ja) 2019-06-14 2022-08-18 ヤンセン ファーマシューティカ エヌ．ベー． 置換ピラゾロピラジン及びｇｌｕｎ２ｂ受容体調節因子としてのそれらの使用
EP3766483A1 (en) 2019-07-19 2021-01-20 BioPharma Synergies, S. L. Orodispersible powder composition comprising a triptan
US20210322343A1 (en) 2020-04-15 2021-10-21 Farzana Shaheen Nasally administered pharmaceutical composition for the treatment of epilepsy and related disorders

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB148879A (en) * 1919-02-14 1921-11-10 Emil Vincance Noser Locks for shift levers of automobiles
US3320282A (en) * 1962-10-29 1967-05-16 Pfizer & Co C Process for preparing esters of 2-hydroxy-3-(3-indolyl) alkanoic acids
US3879410A (en) * 1971-02-08 1975-04-22 Messrs Lab Guidotti & C S P A 4-Aryl-4-oxazolin-2-ones exhibiting myotonic and myorelaxing activity
BE795457A (fr) * 1972-02-16 1973-08-16 Clin Midy Amines indoliques, leur preparation et leur application en therapeutiques
FR2179582B1 (ko) * 1972-04-13 1975-10-10 Synthelabo
US3873559A (en) * 1973-03-30 1975-03-25 Squibb & Sons Inc Heterocyclic carboxamido thiazolinyl indoles
US4042595A (en) * 1973-08-01 1977-08-16 Snam Progetti S.P.A. Processes for the production of heterocyclic compounds
IT995110B (it) * 1973-08-01 1975-11-10 Snam Progetti Procedimento per la produzione di composti eterociclici e prodotti ottenuti
US3931229A (en) * 1973-08-23 1976-01-06 Warner-Lambert Company 3-Thiomethyl-2[2-(dialkylamino)ethyl]indoles
US4049816A (en) * 1975-03-24 1977-09-20 Beecham Group Limited Antiviral 2-amino-5-[1-(indol-3-yl)alkyl]-2-thiazolin-4-ones
US4062862A (en) * 1975-07-04 1977-12-13 Nippon Chemiphar Co., Ltd. 5-Benzyl-2-oxazolidone derivatives and a process for producing the same
GB1482879A (en) * 1975-07-24 1977-08-17 Nippon Chemiphar Co 5-benzyl-2-oxazolidone derivatives and a process for producing the same
GB1469200A (en) * 1975-11-28 1977-03-30 Warner Lambert Co 3-thiomethyl-2-2-dialkylamino-ethyl-indoles
DE2557341A1 (de) * 1975-12-19 1977-06-30 Hoechst Ag Basisch substituierte indolderivate und verfahren zu ihrer herstellung
IT1109002B (it) * 1977-09-22 1985-12-16 Menarini Sas Derivati del 2 oxazolidone e loro metodi di preparazione
US4198501A (en) * 1977-12-20 1980-04-15 Hoffmann-La Roche Inc. Synthesis of tryptophans
US4137404A (en) * 1977-12-20 1979-01-30 Hoffmann-La Roche Inc. Synthesis of tryptophans
JPS6014032B2 (ja) * 1978-01-20 1985-04-11 日本ケミフア株式会社東京 ５‐フエネチル‐２‐オキサゾリドン誘導体およびその製法
US4348393A (en) * 1978-06-09 1982-09-07 Delalande S.A. N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
DE2933636A1 (de) * 1978-08-30 1980-03-20 Sandoz Ag Neue n-phenylindolinderivate, ihre herstellung und pharmazeutische praeparate, welche diese verbindungen enthalten
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
US4255432A (en) * 1979-09-06 1981-03-10 Syntex (U.S.A.) Inc. 8-[2-3-Indolyl)ethyl]-1-oxa-3-,8-diazaspiro[4.5]decan-2-ones, pharmaceutical compositions thereof and methods of use thereof
US4272555A (en) * 1979-09-21 1981-06-09 Monsanto Company Conversion of carbon-containing materials to carbon monoxide
DE3164982D1 (de) * 1980-04-10 1984-08-30 Sandoz Ag Isoxazolyl indolamines
JPS574986A (en) * 1980-06-13 1982-01-11 Paamakemu Asia:Kk Preparation of oxazolidine derivative
US4753956A (en) * 1981-01-02 1988-06-28 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
US4367234A (en) * 1980-07-28 1983-01-04 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
ZW19381A1 (en) * 1980-08-12 1983-03-09 Glaxo Group Ltd Heterocyclic compounds
IT1171449B (it) * 1980-08-12 1987-06-10 Glaxo Group Ltd Composti eterociclici indolici procedimento per produrli e composizioni farmaceutiche che li contengono
BE889931A (fr) * 1980-08-12 1982-02-11 Glaxo Group Ltd Derives indoliques, leur preparation et leurs applications en tant que medicaments
US4407811A (en) * 1981-01-02 1983-10-04 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
US4399296A (en) * 1981-01-02 1983-08-16 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
US4448971A (en) * 1981-01-02 1984-05-15 Pfizer Inc. Hypoglycemic 5-phenyl-substituted oxazolidine-2,4-diones
JPS57169458A (en) * 1981-04-13 1982-10-19 Paamakemu Asia:Kk Preparation of indole derivative
CH656124A5 (de) * 1982-04-13 1986-06-13 Sandoz Ag 2-substituierte-3-indolamine, verfahren zu deren herstellung sowie deren verwendung.
GR79215B (ko) * 1982-06-07 1984-10-22 Glaxo Group Ltd
US4803218A (en) * 1982-09-29 1989-02-07 Mcneilab, Inc. 3-aminoalkyl-1H-indole-5-urea and amide derivatives
US4500717A (en) * 1983-03-28 1985-02-19 The Dow Chemical Company Process for preparation of 2-oxazolidinones
US4831153A (en) * 1983-06-27 1989-05-16 The Dow Chemical Company Preparation of N-vinyl-2-oxazolidinone
GB8321813D0 (en) * 1983-08-12 1983-09-14 Vickers Plc Radiation sensitive compounds
DE3333450A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Trihalogenmethylgruppen enthaltende carbonylmethylenheterocyclen, verfahren zu ihrer herstellung und lichtempfindliches gemisch, das diese verbindungen enthaelt
HU196752B (en) * 1983-12-06 1989-01-30 Glaxo Group Ltd Process for production of medical compositions containing indole-derivatives and these compounds
DE3430284A1 (de) * 1984-08-17 1986-02-27 Troponwerke GmbH & Co KG, 5000 Köln Neue tryptamin-derivate, ein verfahren zu ihrer herstellung und ihre verwendung
IT1181741B (it) * 1984-12-04 1987-09-30 Glaxo Group Ltd Derivati di indolo,procedimento per prepararli e composizioni farmaceutiche che li contengono
GB8431426D0 (en) * 1984-12-13 1985-01-23 Glaxo Group Ltd Chemical compounds
DE3514696A1 (de) * 1985-04-24 1986-11-06 Bayer Ag, 5090 Leverkusen N-indolylethyl-sulfonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung
DE3531658A1 (de) * 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Heterocyclisch substituierte indole, zwischenprodukte, verfahren zu ihrer herstellung und arzneimittel
US4833153A (en) * 1985-11-08 1989-05-23 Glaxo Group Limited Indole derivatives
GB8531612D0 (en) * 1985-12-23 1986-02-05 Beecham Wuelfing Gmbh & Co Kg Compounds
SE451840B (sv) * 1986-01-03 1987-11-02 Astra Laekemedel Ab Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning
GB8600398D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8607824D0 (en) * 1986-03-27 1986-04-30 Glaxo Group Ltd Chemical compounds
DE3643957A1 (de) * 1986-12-22 1988-06-30 Bayer Ag Substituierte n-methylisoxazolidine
PT88255B (pt) * 1987-08-13 1995-03-01 Glaxo Group Ltd Processo para a preparacao de derivados do indole
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
DE3730777A1 (de) * 1987-09-12 1989-03-23 Basf Ag Verfahren zur herstellung von imidazolidinonen und oxazolidinonen
US4965268A (en) * 1987-10-09 1990-10-23 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4801600A (en) * 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4921869A (en) * 1987-10-09 1990-05-01 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
GB8724912D0 (en) * 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
DE3823299A1 (de) * 1988-07-07 1990-01-11 Schering Ag Substituierte phenyl-pyrrolidin-2-one, -oxazolidin-2-one und -imidazolidin-2-one, ihre herstellung sowie verwendung in arzneimitteln
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
DE68929303T2 (de) * 1988-09-15 2002-05-02 Pharmacia & Upjohn Co., Kalamazoo 3-(Stickstoff substituierte)phenyl-5-beta-amidomethyloxazoliden-2-one
US5164510A (en) * 1988-09-15 1992-11-17 The Upjohn Company 5'Indolinyl-5β-amidomethyloxazolidin-2-ones
DE3939238A1 (de) * 1989-11-28 1991-05-29 Bayer Ag Heterocyclisch substituierte acrylsaeureester
DE4013907A1 (de) * 1990-04-26 1991-10-31 Schering Ag Verfahren zur herstellung von gramin-derivaten
CZ283018B6 (cs) * 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
GB9104136D0 (en) * 1991-02-27 1991-04-17 Merck Sharp & Dohme Therapeutic agents
US5409941A (en) * 1992-02-03 1995-04-25 Pfizer Inc. 5-heteroyl indole derivatives

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LT3264B (en) 1995-05-25
HU211479A9 (en) 1995-11-28
UA37178C2 (uk) 2001-05-15
FI106262B (fi) 2000-12-29
AU7957091A (en) 1991-12-31
CA2282890A1 (en) 1991-12-08
NZ238424A (en) 1993-12-23
DE69132691T2 (de) 2002-06-20
EP0486666A1 (en) 1992-05-27
CA2064815A1 (en) 1991-12-08
NL980001I2 (nl) 1998-05-06
CS172791A3 (en) 1992-02-19
DE69132691D1 (de) 2001-09-20
SI21560B (sl) 2005-04-30
EG19650A (en) 1995-09-30
IL114690A (en) 1997-02-18
YU101091A (sh) 1994-04-05
SA05260104A (ar) 2005-12-03
YU48855B (sh) 2002-06-19
DE19775091I2 (de) 2007-05-24
US5863935A (en) 1999-01-26
LTIP419A (en) 1994-11-25
NL980001I1 (nl) 1998-03-02
SI9111010B (sl) 2005-02-28
ES2104708T3 (es) 1997-10-16
MY110226A (en) 1998-03-31
EP0636623B1 (en) 2001-08-16
CZ288351B6 (en) 2001-05-16
ATE204275T1 (de) 2001-09-15
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NO300634B1 (no) 1997-06-30
LV10274A (lv) 1994-10-20
MC2210A1 (fr) 1992-11-26
DE69127260D1 (de) 1997-09-18
NO920494L (no) 1992-03-30
HUT62289A (en) 1993-04-28
RU2160736C2 (ru) 2000-12-20
PT97888A (pt) 1992-05-29
SK281621B6 (sk) 2001-05-10
WO1991018897A1 (en) 1991-12-12
PL166214B1 (pl) 1995-04-28
FI20001406A (fi) 2000-06-13
HRP940524B1 (en) 1998-10-31
EP0636623A1 (en) 1995-02-01
FI920503A0 (fi) 1992-02-06
IE911931A1 (en) 1991-12-18
FI960155A (fi) 1996-01-12
DE69127260T2 (de) 1997-12-04
PT97888B (pt) 1998-12-31
HU9200384D0 (en) 1992-06-29
GR3024828T3 (en) 1998-01-30
DK0486666T3 (da) 1998-03-30
FI960155A0 (fi) 1996-01-12
SI21560A (sl) 2005-02-28
CA2282890C (en) 2001-07-31
US5399574A (en) 1995-03-21
EP0486666B1 (en) 1997-08-13
IL98392A0 (en) 1992-07-15
FI105686B (fi) 2000-09-29
NO1998005I1 (no) 1998-01-21
IL114690A0 (en) 1995-11-27
LU90205I2 (fr) 1998-04-06
US5466699A (en) 1995-11-14
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ATE156823T1 (de) 1997-08-15
KR100215627B1 (ko) 1999-08-16
AU646871B2 (en) 1994-03-10
JP2738461B2 (ja) 1998-04-08
HRP940524A2 (en) 1996-06-30
IL98392A (en) 1996-01-19
HU219974B (hu) 2001-10-28
IE20010862A1 (en) 2003-03-05
HK1000534A1 (en) 1998-04-03
JPH05502679A (ja) 1993-05-13
MX9203421A (es) 1992-07-01
SI9111010A (en) 1997-12-31
LV10274B (en) 1995-04-20

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