DE68929303T2 - 3-(Stickstoff substituierte)phenyl-5-beta-amidomethyloxazoliden-2-one - Google Patents

3-(Stickstoff substituierte)phenyl-5-beta-amidomethyloxazoliden-2-one

Info

Publication number
DE68929303T2
DE68929303T2 DE68929303T DE68929303T DE68929303T2 DE 68929303 T2 DE68929303 T2 DE 68929303T2 DE 68929303 T DE68929303 T DE 68929303T DE 68929303 T DE68929303 T DE 68929303T DE 68929303 T2 DE68929303 T2 DE 68929303T2
Authority
DE
Germany
Prior art keywords
alkyl
phenyl
beta
substd
spirocyclopropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68929303T
Other languages
English (en)
Other versions
DE68929303D1 (de
Inventor
Steven L Brickner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Publication of DE68929303D1 publication Critical patent/DE68929303D1/de
Application granted granted Critical
Publication of DE68929303T2 publication Critical patent/DE68929303T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
DE68929303T 1988-09-15 1989-08-22 3-(Stickstoff substituierte)phenyl-5-beta-amidomethyloxazoliden-2-one Expired - Fee Related DE68929303T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24498888A 1988-09-15 1988-09-15
US25385088A 1988-10-05 1988-10-05
US32494289A 1989-03-17 1989-03-17

Publications (2)

Publication Number Publication Date
DE68929303D1 DE68929303D1 (de) 2001-07-12
DE68929303T2 true DE68929303T2 (de) 2002-05-02

Family

ID=27399816

Family Applications (2)

Application Number Title Priority Date Filing Date
DE68929303T Expired - Fee Related DE68929303T2 (de) 1988-09-15 1989-08-22 3-(Stickstoff substituierte)phenyl-5-beta-amidomethyloxazoliden-2-one
DE68918792T Expired - Fee Related DE68918792T2 (de) 1988-09-15 1989-08-22 5-Indolinyl-5-beta-amidomethyloxazolidin-2-one, 3-(substituierte kondensierte)phenyl-5-beta amidomethyloxazolidin-2-one und 3-(Nitrogen-substituierte)phenyl-5-beta-amidomethyloxazolidin-2-one.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE68918792T Expired - Fee Related DE68918792T2 (de) 1988-09-15 1989-08-22 5-Indolinyl-5-beta-amidomethyloxazolidin-2-one, 3-(substituierte kondensierte)phenyl-5-beta amidomethyloxazolidin-2-one und 3-(Nitrogen-substituierte)phenyl-5-beta-amidomethyloxazolidin-2-one.

Country Status (14)

Country Link
EP (3) EP0434714A1 (de)
JP (2) JP2865211B2 (de)
KR (1) KR0138262B1 (de)
AT (2) ATE201870T1 (de)
AU (1) AU617871B2 (de)
CA (1) CA1335103C (de)
DE (2) DE68929303T2 (de)
DK (2) DK175696B1 (de)
ES (1) ES2157934T3 (de)
GR (1) GR3036491T3 (de)
HK (1) HK1002234A1 (de)
LV (1) LV12888B (de)
TW (1) TW219936B (de)
WO (1) WO1990002744A1 (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5231188A (en) * 1989-11-17 1993-07-27 The Upjohn Company Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents
MC2210A1 (fr) * 1990-06-07 1992-11-26 Wellcome Found Composes heterocycliques therapeutiques,leur utilisation et procede pour les preparer
AU665367B2 (en) * 1991-08-14 1996-01-04 Procter & Gamble Pharmaceuticals, Inc. Cyclic urethanes useful as antiarrhythmic and antifibrillatory agents
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
CA2136324A1 (en) * 1992-07-08 1994-01-20 Steven Joseph Brickner 5'-indolinyl oxazolidinones useful against mycobacterium tuberculosis
US5688792A (en) * 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
DE4425609A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Benzofuranyl- und Benzothienyloxazolidinone
DE4425613A1 (de) * 1994-07-20 1996-01-25 Bayer Ag 5-gliedrige Heteroaryl-oxazolidinone
DE4425612A1 (de) * 1994-07-20 1996-04-04 Bayer Ag 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone
DE19514313A1 (de) * 1994-08-03 1996-02-08 Bayer Ag Benzoxazolyl- und Benzothiazolyloxazolidinone
PT788498E (pt) * 1994-10-26 2002-02-28 Upjohn Co Compostos antimicrobianos de feniloxazolidinona
CN1046520C (zh) * 1994-11-15 1999-11-17 法玛西雅厄普约翰美国公司 二环噁嗪及噻嗪噁唑烷酮抗菌剂
NZ302844A (en) * 1995-02-03 1999-06-29 Upjohn Co Antimicrobial hetero-aromatic ring substituted phenyloxazolidinones
HRP960159A2 (en) * 1995-04-21 1997-08-31 Bayer Ag Benzocyclopentane oxazolidinones containing heteroatoms
CA2218088A1 (en) * 1995-05-11 1996-11-14 Pharmacia & Upjohn Company Spirocyclic and bicyclic diazinyl and carbazinyl oxazolidinones
MX9703040A (es) * 1995-09-12 1997-07-31 Upjohn Co Antimicrobianos de feniloxazolidinona.
ZA968661B (en) * 1995-11-17 1998-04-14 Upjohn Co Oxazolidinone antibacterial agent with tricyclic substituents.
DE19601265A1 (de) 1996-01-16 1997-07-17 Bayer Ag 2-Oxo- und 2-Thio-1,2-dihydrochinolinyl-oxazolidinone
DE19601264A1 (de) 1996-01-16 1997-07-17 Bayer Ag Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone
DE19601627A1 (de) 1996-01-18 1997-07-24 Bayer Ag Heteroatomhaltige Cyclopentanopyridyl-Oxazolidinone
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
HRP970049A2 (en) 1996-02-06 1998-04-30 Bayer Ag New heteroaryl oxazolidinones
DE19604223A1 (de) 1996-02-06 1997-08-07 Bayer Ag Neue substituierte Oxazolidinone
GB9702213D0 (en) * 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
GB9609919D0 (en) * 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
US6255304B1 (en) 1997-05-30 2001-07-03 Pharmacia & Upjohn Company Oxazolidinone antibacterial agents having a thiocarbonyl functionality
EP0984947B8 (de) * 1997-05-30 2005-06-15 Pharmacia & Upjohn Company LLC Antibakteriell wirksam oxazolidinone mit einer thiocarbonylfunktionalität
DE19730847A1 (de) * 1997-07-18 1999-01-28 Bayer Ag Tricyclisch substituierte Oxazolidinone
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
HUP0100470A3 (en) * 1997-11-12 2002-08-28 Upjohn Co Oxazolidinone derivatives and pharmaceutical compositions containing them
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
DE19802239A1 (de) * 1998-01-22 1999-07-29 Bayer Ag Neue mit Bicyclen substituierte Oxazolidinone
US6562844B2 (en) 1998-01-23 2003-05-13 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
US7002020B1 (en) 1998-01-23 2006-02-21 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
US6239152B1 (en) 1998-01-23 2001-05-29 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
NZ515754A (en) 1999-05-27 2003-10-31 Upjohn Co Bicyclic oxazolidinone compounds, pharmaceuticals thereof and their use as antibacterial agents
MXPA02000985A (es) 1999-07-28 2002-07-30 Upjohn Co Oxazolidinonas y su uso como antiinfecciosos.
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
HUP0302918A2 (hu) 2000-07-17 2003-12-29 Ranbaxy Laboratories Limited Mikrobaellenes oxazolidinonszármazékok és a vegyületeket tartalmazó gyógyászati készítmények és eljárás a vegyületek előállítására
US6777441B2 (en) 2000-10-02 2004-08-17 Emory University Triptolide analogs for the treatment of autoimmune and inflammatory disorders
PE20020689A1 (es) 2000-11-17 2002-08-03 Upjohn Co Oxazolidinonas con un heterociclo de 6 o 7 miembros unidos con enlace anular al benceno
US6956040B2 (en) 2001-07-16 2005-10-18 Ranbaxy Laboratories Limited Oxazolidinone piperazinyl derivatives as potential antimicrobials
GB0118407D0 (en) * 2001-07-27 2001-09-19 Cipla Ltd Oxazolidinone derivatives as antibacterial agents
TW200306819A (en) 2002-01-25 2003-12-01 Vertex Pharma Indazole compounds useful as protein kinase inhibitors
US7012088B2 (en) 2003-02-24 2006-03-14 Pharmacia & Upjohn Company Indolone oxazolidinones and derivatives thereof
EP1781643A1 (de) * 2004-08-06 2007-05-09 Pharmacia & Upjohn Company LLC Oxindol-oxazolidinone als antibakterielle mittel
SE0402763D0 (sv) * 2004-11-11 2004-11-11 Astrazeneca Ab Nitro indazole derivatives
AU2006231919A1 (en) 2005-04-06 2006-10-12 Pharmacia & Upjohn Company Llc 7-fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents
EP1869029A1 (de) * 2005-04-06 2007-12-26 Pharmacia & Upjohn Company LLC Ein oxindoloxazolidinon als antibakterielles mittel
NZ585752A (en) * 2007-12-24 2011-11-25 Cipla Ltd Process for the synthesis of propargylated aminoindan derivatives
US8598156B2 (en) 2010-03-25 2013-12-03 Glaxosmithkline Llc Chemical compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES533097A0 (es) * 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
CA1260948A (en) * 1984-12-05 1989-09-26 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents
US4801600A (en) * 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents

Also Published As

Publication number Publication date
KR0138262B1 (ko) 1998-05-15
JP3188418B2 (ja) 2001-07-16
EP0434714A1 (de) 1991-07-03
ATE201870T1 (de) 2001-06-15
AU4195789A (en) 1990-04-02
DK175940B1 (da) 2005-08-01
ES2157934T3 (es) 2001-09-01
ATE112773T1 (de) 1994-10-15
KR900701780A (ko) 1990-12-04
GR3036491T3 (en) 2001-11-30
EP0359418B1 (de) 1994-10-12
DK175696B1 (da) 2005-01-24
DK200401246A (da) 2004-08-18
TW219936B (de) 1994-02-01
DE68929303D1 (de) 2001-07-12
JPH04500665A (ja) 1992-02-06
AU617871B2 (en) 1991-12-05
EP0359418A1 (de) 1990-03-21
EP0609905A1 (de) 1994-08-10
DK45591A (da) 1991-03-13
DE68918792D1 (de) 1994-11-17
HK1002234A1 (en) 1998-08-07
CA1335103C (en) 1995-04-04
JPH1180139A (ja) 1999-03-26
WO1990002744A1 (en) 1990-03-22
EP0609905B1 (de) 2001-06-06
JP2865211B2 (ja) 1999-03-08
DK45591D0 (da) 1991-03-13
DE68918792T2 (de) 1995-03-30
LV12888B (en) 2002-12-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee