LTIP419A - Therapeutic heterocyclic compounds - Google Patents

Therapeutic heterocyclic compounds

Info

Publication number
LTIP419A
LTIP419A LTIP419A LTIP419A LTIP419A LT IP419 A LTIP419 A LT IP419A LT IP419 A LTIP419 A LT IP419A LT IP419 A LTIP419 A LT IP419A LT IP419 A LTIP419 A LT IP419A
Authority
LT
Lithuania
Prior art keywords
formula
heterocyclic compounds
alkyl
therapeutic heterocyclic
therapeutic
Prior art date
Application number
LTIP419A
Inventor
Alan Duncan Robertson
Alan Peter Hill
Robert Charles Glen
Graeme Richard Martin
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26297174&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LTIP419(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB909012672A external-priority patent/GB9012672D0/en
Priority claimed from GB919102182A external-priority patent/GB9102182D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of LTIP419A publication Critical patent/LTIP419A/en
Publication of LT3264B publication Critical patent/LT3264B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Heterocyclic cpds of formula (I), and their salts are new n = integer from 0 to 3. W = gp of formula (i), (ii) or (iii). R = H or 1-4C alkyl, X = -0-, -S-, -NH- or -CH2-Y = 0 or S. The chiral centre inm (i) or (ii) is in its (S) or (R) form or is a mixt thereof in any proportion. Z = a gp of formula (iv), (v) or (vi), R1 and R2 are independently H or 1-4C alkyl. R3 = H or 1-4C alkyl. Also claimed are the use of (I) in pharmaceutical compsns and processes for their prepn. Pref n = 1, W = a gp of formula (i) wherein R = H, X = -0- and Y = 0 Z = a gp of formula (iv) or (vi) R1 = R2 = H or CH3.
LTIP419A 1990-06-07 1993-03-15 Therapeutic heterocyclic compounds LT3264B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB909012672A GB9012672D0 (en) 1990-06-07 1990-06-07 Therapeutic heterocyclic compounds
GB919102182A GB9102182D0 (en) 1991-02-01 1991-02-01 Therapeutic heterocyclic compounds
PCT/GB1991/000908 WO1991018897A1 (en) 1990-06-07 1991-06-06 Therapeutic heterocyclic compounds

Publications (2)

Publication Number Publication Date
LTIP419A true LTIP419A (en) 1994-11-25
LT3264B LT3264B (en) 1995-05-25

Family

ID=26297174

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP419A LT3264B (en) 1990-06-07 1993-03-15 Therapeutic heterocyclic compounds

Country Status (36)

Country Link
US (3) US5399574A (en)
EP (2) EP0486666B1 (en)
JP (1) JP2738461B2 (en)
KR (1) KR100215627B1 (en)
AT (2) ATE156823T1 (en)
AU (1) AU646871B2 (en)
CA (2) CA2282890C (en)
CZ (1) CZ288351B6 (en)
DE (3) DE69127260T2 (en)
DK (1) DK0486666T3 (en)
EG (1) EG19650A (en)
ES (1) ES2104708T3 (en)
FI (3) FI105686B (en)
GR (1) GR3024828T3 (en)
HR (1) HRP940524B1 (en)
HU (2) HU219974B (en)
IE (1) IE911931A1 (en)
IL (3) IL114690A (en)
LT (1) LT3264B (en)
LU (1) LU90205I2 (en)
LV (1) LV10274B (en)
MC (1) MC2210A1 (en)
MX (1) MX9203421A (en)
MY (1) MY110226A (en)
NL (1) NL980001I2 (en)
NO (2) NO300634B1 (en)
NZ (1) NZ238424A (en)
PL (1) PL166214B1 (en)
PT (1) PT97888B (en)
RU (1) RU2160736C2 (en)
SA (1) SA05260104B1 (en)
SI (2) SI21560B (en)
SK (1) SK281621B6 (en)
UA (1) UA37178C2 (en)
WO (1) WO1991018897A1 (en)
YU (1) YU48855B (en)

Families Citing this family (128)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ283018B6 (en) * 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Imidazole, triazole and tetrazole derivatives, process of their preparation, their use and pharmaceuticals based thereon
TW263508B (en) * 1991-02-12 1995-11-21 Pfizer
HUT69705A (en) * 1991-11-25 1995-09-28 Pfizer Indole derivatives
GB9201038D0 (en) * 1992-01-16 1992-03-11 Glaxo Group Ltd Chemical compounds
TW288010B (en) * 1992-03-05 1996-10-11 Pfizer
ATE205202T1 (en) * 1992-03-13 2001-09-15 Merck Sharp & Dohme IMIDAZOLE, TRIAZOLE AND TETRAZOLE DERIVATIVES
GB9207396D0 (en) * 1992-04-03 1992-05-13 Merck Sharp & Dohme Therapeutic agents
US6380233B1 (en) 1992-04-07 2002-04-30 Pfizer Inc Indole derivatives as 5-HT1 agonists
US5747501A (en) 1992-04-07 1998-05-05 Pfizer, Inc. Indole derivatives
GB9207930D0 (en) * 1992-04-10 1992-05-27 Pfizer Ltd Indoles
NZ251047A (en) * 1992-04-10 1996-09-25 Pfizer Acylaminoindole derivatives and medicaments
GB9208161D0 (en) * 1992-04-14 1992-05-27 Pfizer Ltd Indoles
GB9208463D0 (en) * 1992-04-16 1992-06-03 Merck Sharp & Dohme Therapeutic agents
GB9209882D0 (en) * 1992-05-07 1992-06-24 Glaxo Lab Sa Compositions
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
JPH07509452A (en) * 1992-07-24 1995-10-19 メルク　シヤープ　エンド　ドーム　リミテツド Imidazole, triazole and tetrazole derivatives
GB9216009D0 (en) * 1992-07-28 1992-09-09 Almirall Lab New indol derivatives
IL106445A (en) * 1992-07-30 1998-01-04 Merck Sharp & Dohme 4-substituted 1, 2, 4-triazole derivatives, their preparation and pharmaceutical compositions containing them
ES2056025B1 (en) * 1992-10-08 1995-05-01 Almirall Lab NEW DERIVATIVES OF INDOL.
TW251284B (en) * 1992-11-02 1995-07-11 Pfizer
GB9226532D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
FR2701026B1 (en) * 1993-02-02 1995-03-31 Adir New derivatives of indole, indazole and benzisoxazole, process for their preparation and pharmaceutical compositions containing them.
ES2070087B1 (en) * 1993-08-13 1996-02-16 Pfizer DERIVATIVES OF INDOL
KR100191973B1 (en) * 1993-08-31 1999-06-15 디. 제이. 우드, 스피겔 알렌 제이 5-arylindole derivative
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
US6423731B2 (en) * 1994-01-06 2002-07-23 Zeneca Limited Indole derivatives as prodrugs of 5-HT1-like receptor agonists
GB9401436D0 (en) * 1994-01-26 1994-03-23 Wellcome Found Therapeutic heterocyclic compounds
EP0759918A1 (en) * 1994-05-19 1997-03-05 MERCK SHARP & DOHME LTD. Piperazine, piperidine and tetrahydropyridine derivatives of indol-3-ylalkyl as 5-ht1d-alpha agonists
DE69521895T2 (en) * 1994-06-01 2002-04-04 Astrazeneca Ab, Soedertaelje INDOLDER DERIVATIVES AS PRODRUGS BY "5-HT1-LIKE" RECEPTOR AGONISTS
FI970310L (en) * 1994-07-26 1997-01-24 Pfizer 4-Indole derivatives as serotonin agonists and antagonists
US5521196A (en) * 1994-10-05 1996-05-28 Eli Lilly And Company 5-HT1F agonists for the treatment of migraine
GB9423682D0 (en) * 1994-11-23 1995-01-11 Merck Sharp & Dohme Therapeutic agents
US5521197A (en) * 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
US6025374A (en) * 1994-12-06 2000-02-15 Merck Sharp & Dohme, Ltd. Azetidine, pyrrolidine and piperidine derivatives as 5HT1 receptor agonists
DE4443892A1 (en) * 1994-12-09 1996-06-13 Bayer Ag 4- (Quinolin-2-yl-methoxy) phenyl acetic acid derivatives
GB9501865D0 (en) * 1995-01-31 1995-03-22 Merck Sharp & Dohme Therapeutic agents
WO1996029075A1 (en) * 1995-03-20 1996-09-26 Eli Lilly And Company 5-substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1h-indoles: new 5-ht1f agonists
GB9515060D0 (en) * 1995-07-22 1995-09-20 Wellcome Found Therapeutic heterocyclic compounds
GB9515305D0 (en) * 1995-07-26 1995-09-20 Wellcome Found Therapeutic heterocyclic compounds
US6909005B1 (en) 1995-08-07 2005-06-21 Astrazeneca Uk Limited One post synthesis of 2-oxazolidinone derivatives
GB9516145D0 (en) * 1995-08-07 1995-10-04 Wellcome Found Improved chemical synthesis
GB9516143D0 (en) * 1995-08-07 1995-10-04 Wellcome Found Improved chemical synthesis
WO1997013512A1 (en) * 1995-10-10 1997-04-17 Eli Lilly And Company N-[2-substituted-3-(2-aminoethyl)-1h-indol-5-yl]-amides: new 5-ht1f agonists
US5998415A (en) * 1995-11-02 1999-12-07 Merck Sharp & Dohme Ltd. Bicyclic heteroaryl-alkylene-(homo)piperazinones and thione analogues thereof, their preparation, and their use of as selective agonists of 5-HT1 -like receptors
GB9609374D0 (en) * 1996-05-03 1996-07-10 Merck Sharp & Dohme Therapeutic agents
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
GB9706089D0 (en) 1997-03-24 1997-05-14 Scherer Ltd R P Pharmaceutical composition
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
AR017200A1 (en) 1997-12-23 2001-08-22 Astrazeneca Ab INHIBITING COMPOUNDS OF PROTEIN CINASE C, PHARMACEUTICALLY ACCEPTABLE SALTS OF THE SAME, PHARMACEUTICAL FORMULATIONS THAT UNDERSTAND THEM, USE THE SAME AND PROCESS FOR THE SYNTHESIS OF SUCH COMPOUNDS
SE9800835D0 (en) 1998-03-13 1998-03-13 Astra Ab New Compounds
WO2000000490A2 (en) * 1998-06-26 2000-01-06 Eli Lilly And Company 5-ht1f agonists
US6492406B1 (en) 1999-05-21 2002-12-10 Astrazeneca Ab Pharmaceutically active compounds
US6346625B1 (en) * 1999-06-23 2002-02-12 Astrazeneca Ab Protein kinase inhibitors
GB9928578D0 (en) * 1999-12-03 2000-02-02 Zeneca Ltd Pharmaceutical formulations
ATE374192T1 (en) * 2000-11-29 2007-10-15 Lilly Co Eli 1-(2-M-METHANESULFONAMIDOPHENYLETHYL)-4-(M-TRIFLUOROMETHYLPHENYL)PIPERAZINE AND THEIR ACCEPTABLE PHARMACEUTICAL SALTS AND SOLVATES AND THEIR USE FOR THE TREATMENT OF INCONTINENCE
US7090830B2 (en) * 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
US20070122353A1 (en) * 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US20030051728A1 (en) * 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
US7585493B2 (en) 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US7458374B2 (en) * 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US8329734B2 (en) 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
DK1435945T3 (en) * 2001-06-05 2008-12-01 Ronald Aung-Din Topical migraine therapy
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
EP2316468A1 (en) 2002-02-22 2011-05-04 Shire LLC Delivery system and methods for protecting and administering dextroamphetamine
DE60329607D1 (en) 2002-06-21 2009-11-19 Suven Life Sciences Ltd CONTAINING THERAPEUTIC AGENT ARYL ALKYLINDOLE WITH AFFINITY FOR THE SEROTONIN RECEPTOR, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF
DK1523486T3 (en) 2002-06-21 2008-03-03 Suven Life Sciences Ltd Tetracyclic arylsulfonyl indoles with serotonin receptor affinity
ES2204302B2 (en) 2002-08-07 2005-03-01 Laboratorios Vita, S.A. PROCEDURE FOR OBTAINING A PHARMACEUTICALLY ACTIVE COMPOUND.
DE10237722A1 (en) * 2002-08-17 2004-08-19 Aventis Pharma Deutschland Gmbh Indole or benzimidazole derivatives for the modulation of IKappaB kinase
US20040105818A1 (en) * 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) * 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
MXPA05005700A (en) 2002-11-28 2005-08-16 Suven Life Sciences Ltd N-arylsulfonyl-3-aminoalkoxyindoles.
JP4559230B2 (en) 2002-11-28 2010-10-06 スベン ライフ サイエンシズ リミティド Novel N-arylsulfonyl-3-substituted indoles having affinity for serotonin receptors, methods for their preparation, and pharmaceutical compositions containing them
EA009367B1 (en) 2002-12-18 2007-12-28 Сувен Лайф Сайенсиз Лимитед 5-THIA-5-DIOXO-4b AZA INDENO [2,1-a] INDENE DERIVATIVES HAVING SEROTONIN RECEPTOR AFFINITY
US7645886B2 (en) 2002-12-20 2010-01-12 Ciba Specialty Corporation Synthesis of amines and intermediates for the synthesis thereof
WO2004063175A1 (en) * 2003-01-13 2004-07-29 Natco Pharma Limited A novel and an improved process for the preparation of (s)-4-(4-aminobenzyl)-2- oxazolidinone
GB0302094D0 (en) 2003-01-29 2003-02-26 Pharmagene Lab Ltd EP4 receptor antagonists
US20040192958A1 (en) * 2003-03-25 2004-09-30 Hyatt John Anthony Process for preparing derivatives of 4-halobutyraldehyde
US20040234916A1 (en) 2003-05-21 2004-11-25 Alexza Molecular Delivery Corporation Optically ignited or electrically ignited self-contained heating unit and drug-supply unit employing same
TWI287010B (en) * 2003-06-12 2007-09-21 Euro Celtique Sa Therapeutic agents useful for treating pain
US20070065463A1 (en) 2003-06-20 2007-03-22 Ronald Aung-Din Topical therapy for the treatment of migranes, muscle sprains, muscle spasms, spasticity and related conditions
GEP20094676B (en) * 2003-07-24 2009-05-10 Euro Celtique Sa Piperidine compounds and pharmaceutical compositions containing them
GB0324269D0 (en) 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
US20070173536A1 (en) * 2004-02-06 2007-07-26 Ciba Specialty Chemicals Holding Inc. Crystalline forms of zolmitriptan
US7540286B2 (en) * 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
EP1781360A1 (en) * 2004-08-12 2007-05-09 Alexza Pharmaceuticals, Inc. Aerosol drug delivery device incorporating percussively activated heat packages
EP1812428A2 (en) * 2004-11-19 2007-08-01 Teva Pharmaceutical Industries Ltd Zolmitriptan crystal forms
ZA200709038B (en) 2005-04-13 2009-01-28 Neuraxon Inc Substituted indole compounds having nos inhibitory activity
ATE510836T1 (en) 2006-01-19 2011-06-15 Matrix Lab Ltd CONVERSION OF AN AROMATIC DIAZONIUM SALT INTO AN ARYLHYDRAZINE
CN101466709B (en) 2006-04-13 2013-03-20 轴突公司 1,5 and 3,6-substituted indole compounds with NOS inhibitory activity
WO2008018090A2 (en) * 2006-08-09 2008-02-14 Matrix Laboratories Ltd An improved process for the preparation of zolmitriptan
CA2666149A1 (en) * 2006-10-19 2008-04-24 Auspex Pharmaceuticals, Inc. Substituted indoles
WO2008097664A1 (en) * 2007-02-11 2008-08-14 Map Pharmaceuticals, Inc. Method of therapeutic administration of dhe to enable rapid relief of migraine while minimizing side effect profile
CZ2007158A3 (en) * 2007-02-26 2008-10-22 Zentiva, A. S. Process for preparing zolmitriptan
WO2008112661A2 (en) 2007-03-09 2008-09-18 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
MX2009011601A (en) * 2007-04-27 2009-11-10 Purdue Pharma Lp Therapeutic agents useful for treating pain.
CA2685266C (en) 2007-04-27 2014-01-28 Purdue Pharma L.P. Trpv1 antagonists and uses thereof for the treatment of prevention of pain, ui and ulcer, ibd, or ibs in an animal
NZ584971A (en) * 2007-10-03 2012-06-29 Generics Uk Ltd Process for the preparation of zolmitriptan, salts and solvates thereof
WO2009062318A1 (en) * 2007-11-16 2009-05-22 Neuraxon, Inc. 3,5-substituted indole compounds having nos and norepinephrine reuptake inhibitory activity
EA201000808A1 (en) 2007-11-16 2011-04-29 Ньюраксон, Инк. INDOL CONNECTIONS AND METHODS OF TREATMENT OF VISCERAL PAIN
EP2219449A4 (en) * 2007-11-16 2010-10-27 Univ Arizona State METHODS OF TREATING VISCERAL PAIN
CN101181267B (en) * 2007-11-30 2010-09-08 重庆医科大学医药研究所 Zolmitriptan tongue tablet
KR101517415B1 (en) * 2008-05-14 2015-05-07 에스케이바이오팜 주식회사 A sparingly anticonvulsive pharmaceutical composition containing a poorly soluble anticonvulsant
JP2011526889A (en) 2008-06-30 2011-10-20 アフギン ファーマ，エルエルシー Local nerve action therapy
US20100217013A1 (en) * 2008-12-15 2010-08-26 Wenge Li Enantioselective process for the preparation of zolmitriptan
WO2010151804A1 (en) * 2009-06-26 2010-12-29 Map Pharmaceuticals, Inc. Administration of dihydroergotamine mesylate particles using a metered dose inhaler
US20110038928A1 (en) * 2009-08-12 2011-02-17 Glenmark Generics Ltd Orally disintegrating tablets of zolmitriptan
SI2627328T1 (en) 2010-10-15 2017-01-31 Contera Pharma Aps Combinations of serotonin receptor agonists for treatment of movement disorders
PE20141531A1 (en) 2011-06-22 2014-10-23 Purdue Pharma Lp TRPV1 ANTAGONISTS INCLUDING DIHYDROXI SUBSTITUTES AND THEIR USES
WO2013016223A2 (en) 2011-07-22 2013-01-31 The University Of Chicago Treatments for migraine and related disorders
EP2751098B1 (en) 2011-09-02 2017-11-29 Emcure Pharmaceuticals Limited An improved process for preparation of zolmitriptan
CN104411301B (en) 2012-04-18 2018-02-06 康特拉医药公司 Suitable for improving the ORAL FORMULATION of dyskinesia treatment
AU2013361337A1 (en) 2012-12-21 2015-07-09 Map Pharmaceuticals, Inc. 8'-Hydroxy-Dihydroergotamine compounds and compositions
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
HK1244715A1 (en) 2015-03-02 2018-08-17 阿福金制药有限责任公司 Topical regional neuro-affective therapy with cannabinoids
WO2017122161A1 (en) 2016-01-15 2017-07-20 Cadila Healthcare Limited An intranasal composition comprising 5ht1b/1d receptor agonists
WO2017130141A1 (en) 2016-01-27 2017-08-03 Instar Technologies A.S. Oromucosal nanofiber carriers for therapeutic treatment
AU2017297718B2 (en) 2016-07-11 2023-06-08 Contera Pharma A/S Pulsatile drug delivery system for treating morning akinesia
US20180049994A1 (en) 2016-08-16 2018-02-22 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene
US12214118B2 (en) 2018-02-02 2025-02-04 Alexza Pharmaceuticals, Inc. Electrical condensation aerosol device
JP7667097B2 (en) 2019-06-14 2025-04-22 ヤンセン ファーマシューティカ エヌ．ベー． Substituted pyrazolo-pyridine amides and their use as glun2b receptor modulators - Patents.com
CN114008052A (en) 2019-06-14 2022-02-01 詹森药业有限公司 Substituted pyrazolo-pyrazines and their use as modulators of GluN2B receptors
EP3766483A1 (en) 2019-07-19 2021-01-20 BioPharma Synergies, S. L. Orodispersible powder composition comprising a triptan
US20210322343A1 (en) 2020-04-15 2021-10-21 Farzana Shaheen Nasally administered pharmaceutical composition for the treatment of epilepsy and related disorders
CN114394962A (en) * 2021-12-22 2022-04-26 深圳市祥根生物医药有限公司 A kind of preparation method of N-desmethylzolmitriptan

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB148879A (en) * 1919-02-14 1921-11-10 Emil Vincance Noser Locks for shift levers of automobiles
US3320282A (en) * 1962-10-29 1967-05-16 Pfizer & Co C Process for preparing esters of 2-hydroxy-3-(3-indolyl) alkanoic acids
US3879410A (en) * 1971-02-08 1975-04-22 Messrs Lab Guidotti & C S P A 4-Aryl-4-oxazolin-2-ones exhibiting myotonic and myorelaxing activity
BE795457A (en) * 1972-02-16 1973-08-16 Clin Midy INDOLIC AMINES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS
FR2179582B1 (en) * 1972-04-13 1975-10-10 Synthelabo
US3873559A (en) * 1973-03-30 1975-03-25 Squibb & Sons Inc Heterocyclic carboxamido thiazolinyl indoles
IT995110B (en) * 1973-08-01 1975-11-10 Snam Progetti PROCEDURE FOR THE PRODUCTION OF HETEROCYCLIC COMPOUNDS AND OBTAINED PRODUCTS
US4042595A (en) * 1973-08-01 1977-08-16 Snam Progetti S.P.A. Processes for the production of heterocyclic compounds
US3931229A (en) * 1973-08-23 1976-01-06 Warner-Lambert Company 3-Thiomethyl-2[2-(dialkylamino)ethyl]indoles
US4049816A (en) * 1975-03-24 1977-09-20 Beecham Group Limited Antiviral 2-amino-5-[1-(indol-3-yl)alkyl]-2-thiazolin-4-ones
US4062862A (en) * 1975-07-04 1977-12-13 Nippon Chemiphar Co., Ltd. 5-Benzyl-2-oxazolidone derivatives and a process for producing the same
GB1482879A (en) * 1975-07-24 1977-08-17 Nippon Chemiphar Co 5-benzyl-2-oxazolidone derivatives and a process for producing the same
GB1469200A (en) * 1975-11-28 1977-03-30 Warner Lambert Co 3-thiomethyl-2-2-dialkylamino-ethyl-indoles
DE2557341A1 (en) * 1975-12-19 1977-06-30 Hoechst Ag BASIC SUBSTITUTED INDOLDER DERIVATIVES AND THE PROCESS FOR THEIR PRODUCTION
IT1109002B (en) * 1977-09-22 1985-12-16 Menarini Sas DERIVATIVES OF 2 OXAZOLIDONE AND THEIR PREPARATION METHODS
US4198501A (en) * 1977-12-20 1980-04-15 Hoffmann-La Roche Inc. Synthesis of tryptophans
US4137404A (en) * 1977-12-20 1979-01-30 Hoffmann-La Roche Inc. Synthesis of tryptophans
JPS6014032B2 (en) * 1978-01-20 1985-04-11 日本ケミフア株式会社東京 5-phenethyl-2-oxazolidone derivative and its production method
US4348393A (en) * 1978-06-09 1982-09-07 Delalande S.A. N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
DE2933636A1 (en) * 1978-08-30 1980-03-20 Sandoz Ag NEW N-PHENYLINDOL DERIVATIVES, THEIR PRODUCTION AND PHARMACEUTICAL PREPARATIONS THAT CONTAIN THESE COMPOUNDS
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
DK151884C (en) * 1979-03-07 1988-06-13 Pfizer METHOD OF ANALOGUE FOR THE PREPARATION OF 3- (1-IMIDAZOLYLALKYL) INCIDENTAL OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS THEREOF
US4255432A (en) * 1979-09-06 1981-03-10 Syntex (U.S.A.) Inc. 8-[2-3-Indolyl)ethyl]-1-oxa-3-,8-diazaspiro[4.5]decan-2-ones, pharmaceutical compositions thereof and methods of use thereof
US4272555A (en) * 1979-09-21 1981-06-09 Monsanto Company Conversion of carbon-containing materials to carbon monoxide
DE3164982D1 (en) * 1980-04-10 1984-08-30 Sandoz Ag ISOXAZOLYL INDOLAMINES
JPS574986A (en) * 1980-06-13 1982-01-11 Paamakemu Asia:Kk Preparation of oxazolidine derivative
US4753956A (en) * 1981-01-02 1988-06-28 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
US4367234A (en) * 1980-07-28 1983-01-04 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
ZA815541B (en) * 1980-08-12 1983-03-30 Glaxo Group Ltd Heterocyclic compounds
IT1171449B (en) * 1980-08-12 1987-06-10 Glaxo Group Ltd INDOLIC HETEROCYCLIC COMPOUNDS PROCEDURE FOR THE PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
ZW19381A1 (en) * 1980-08-12 1983-03-09 Glaxo Group Ltd Heterocyclic compounds
US4448971A (en) * 1981-01-02 1984-05-15 Pfizer Inc. Hypoglycemic 5-phenyl-substituted oxazolidine-2,4-diones
US4407811A (en) * 1981-01-02 1983-10-04 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
US4399296A (en) * 1981-01-02 1983-08-16 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
JPS57169458A (en) * 1981-04-13 1982-10-19 Paamakemu Asia:Kk Preparation of indole derivative
CH656124A5 (en) * 1982-04-13 1986-06-13 Sandoz Ag 2-SUBSTITUTED-3-INDOLAMINES, METHOD FOR THE PRODUCTION AND USE THEREOF.
IT1170387B (en) * 1982-06-07 1987-06-03 Glaxo Group Ltd HETEROCYCLIC COMPOUNDS, PROCEDURE TO PREPARE THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US4803218A (en) * 1982-09-29 1989-02-07 Mcneilab, Inc. 3-aminoalkyl-1H-indole-5-urea and amide derivatives
US4500717A (en) * 1983-03-28 1985-02-19 The Dow Chemical Company Process for preparation of 2-oxazolidinones
US4831153A (en) * 1983-06-27 1989-05-16 The Dow Chemical Company Preparation of N-vinyl-2-oxazolidinone
GB8321813D0 (en) * 1983-08-12 1983-09-14 Vickers Plc Radiation sensitive compounds
DE3333450A1 (en) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt CARBONYL METHYLENE HETEROCYCLES CONTAINING TRIHALOGEN METHYL GROUPS, METHOD FOR THE PRODUCTION THEREOF AND LIGHT-SENSITIVE MIXTURE THAT CONTAINS THESE COMPOUNDS
GB8332435D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
DE3430284A1 (en) * 1984-08-17 1986-02-27 Troponwerke GmbH & Co KG, 5000 Köln NEW TRYPTAMINE DERIVATIVES, A METHOD FOR THEIR PRODUCTION AND THEIR USE
IT1181741B (en) * 1984-12-04 1987-09-30 Glaxo Group Ltd INDOLATION DERIVATIVES, PROCEDURE TO PREPARE THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
GB8431426D0 (en) * 1984-12-13 1985-01-23 Glaxo Group Ltd Chemical compounds
DE3514696A1 (en) * 1985-04-24 1986-11-06 Bayer Ag, 5090 Leverkusen N-INDOLYLETHYL SULPHONIC ACID AMIDES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
DE3531658A1 (en) * 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh HETEROCYCLICALLY SUBSTITUTED INDOLE, INTERMEDIATE PRODUCTS, METHOD FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS
US4833153A (en) * 1985-11-08 1989-05-23 Glaxo Group Limited Indole derivatives
GB8531612D0 (en) * 1985-12-23 1986-02-05 Beecham Wuelfing Gmbh & Co Kg Compounds
SE451840B (en) * 1986-01-03 1987-11-02 Astra Laekemedel Ab OPTICALLY PURE MONOHYDRATED OF S - (-) - 1-PROPYL-2 ', 6'-PIPECOLOXYLIDE HYDROCHLORIDE, SET TO PREPARE THIS AND PHARMACEUTICAL PREPARATIONS FOR LOCAL ANCHORING
GB8600398D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8607824D0 (en) * 1986-03-27 1986-04-30 Glaxo Group Ltd Chemical compounds
DE3643957A1 (en) * 1986-12-22 1988-06-30 Bayer Ag SUBSTITUTED N-METHYLISOXAZOLIDINE
AU611469B2 (en) * 1987-08-13 1991-06-13 Glaxo Group Limited Indole derivatives
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
DE3730777A1 (en) * 1987-09-12 1989-03-23 Basf Ag METHOD FOR PRODUCING IMIDAZOLIDINONES AND OXAZOLIDINONES
US4801600A (en) * 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4921869A (en) * 1987-10-09 1990-05-01 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4965268A (en) * 1987-10-09 1990-10-23 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
GB8724912D0 (en) * 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
DE3823299A1 (en) * 1988-07-07 1990-01-11 Schering Ag SUBSTITUTED PHENYL-PYRROLIDIN-2-ONE, -OXAZOLIDIN-2-ONE AND -IMIDAZOLIDIN-2-ONE, THEIR PRODUCTION AND USE IN MEDICINAL PRODUCTS
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
US5164510A (en) * 1988-09-15 1992-11-17 The Upjohn Company 5'Indolinyl-5β-amidomethyloxazolidin-2-ones
JP2865211B2 (en) * 1988-09-15 1999-03-08 ファルマシア・アンド・アップジョン・カンパニー 5'-Indolinyl-5β-amidomethyloxazolidin-2-ones, 3- (condensed ring-substituted) phenyl-5β-amidomethyloxazolidine-2-ones and 3- (nitrogen atom-substituted) phenyl-5β-amidomethyloxazolidine -2-ones
DE3939238A1 (en) * 1989-11-28 1991-05-29 Bayer Ag HETEROCYCLICALLY SUBSTITUTED ACRYLIC ACID ESTERS
DE4013907A1 (en) * 1990-04-26 1991-10-31 Schering Ag Prepn. of 3-alkylamino methyl-indole derivs. from indole deriv.
CZ283018B6 (en) * 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Imidazole, triazole and tetrazole derivatives, process of their preparation, their use and pharmaceuticals based thereon
GB9104136D0 (en) * 1991-02-27 1991-04-17 Merck Sharp & Dohme Therapeutic agents
US5409941A (en) * 1992-02-03 1995-04-25 Pfizer Inc. 5-heteroyl indole derivatives

Also Published As

Publication number Publication date
MC2210A1 (en) 1992-11-26
LV10274A (en) 1994-10-20
SI21560A (en) 2005-02-28
JP2738461B2 (en) 1998-04-08
SI9111010A (en) 1997-12-31
SA05260104A (en) 2005-12-03
IL98392A (en) 1996-01-19
HRP940524B1 (en) 1998-10-31
DE69132691D1 (en) 2001-09-20
DE69132691T2 (en) 2002-06-20
US5466699A (en) 1995-11-14
SI21560B (en) 2005-04-30
HK1000534A1 (en) 1998-04-03
PT97888A (en) 1992-05-29
NO300634B1 (en) 1997-06-30
HU9200384D0 (en) 1992-06-29
DK0486666T3 (en) 1998-03-30
FI960155A0 (en) 1996-01-12
UA37178C2 (en) 2001-05-15
LU90205I2 (en) 1998-04-06
ES2104708T3 (en) 1997-10-16
DE69127260T2 (en) 1997-12-04
US5399574A (en) 1995-03-21
EP0636623A1 (en) 1995-02-01
SK281621B6 (en) 2001-05-10
GR3024828T3 (en) 1998-01-30
EG19650A (en) 1995-09-30
HRP940524A2 (en) 1996-06-30
FI920503A0 (en) 1992-02-06
EP0486666A1 (en) 1992-05-27
CA2064815A1 (en) 1991-12-08
IE20010862A1 (en) 2003-03-05
CA2282890C (en) 2001-07-31
NO920494D0 (en) 1992-02-06
CS172791A3 (en) 1992-02-19
MY110226A (en) 1998-03-31
NO1998005I1 (en) 1998-01-21
WO1991018897A1 (en) 1991-12-12
EP0486666B1 (en) 1997-08-13
PT97888B (en) 1998-12-31
CZ288351B6 (en) 2001-05-16
CA2282890A1 (en) 1991-12-08
MX9203421A (en) 1992-07-01
IE911931A1 (en) 1991-12-18
JPH05502679A (en) 1993-05-13
KR920702359A (en) 1992-09-03
FI20001406A7 (en) 2000-06-13
LT3264B (en) 1995-05-25
AU7957091A (en) 1991-12-31
HU211479A9 (en) 1995-11-28
FI105686B (en) 2000-09-29
PL166214B1 (en) 1995-04-28
CA2064815C (en) 1999-11-16
NZ238424A (en) 1993-12-23
SA05260104B1 (en) 2006-04-04
RU2160736C2 (en) 2000-12-20
IL114690A0 (en) 1995-11-27
SI9111010B (en) 2005-02-28
DE19775091I2 (en) 2007-05-24
IL114690A (en) 1997-02-18
HU219974B (en) 2001-10-28
YU101091A (en) 1994-04-05
LV10274B (en) 1995-04-20
FI106262B (en) 2000-12-29
ATE156823T1 (en) 1997-08-15
NO920494L (en) 1992-03-30
US5863935A (en) 1999-01-26
DE69127260D1 (en) 1997-09-18
IL98392A0 (en) 1992-07-15
KR100215627B1 (en) 1999-08-16
EP0636623B1 (en) 2001-08-16
HUT62289A (en) 1993-04-28
NL980001I1 (en) 1998-03-02
ATE204275T1 (en) 2001-09-15
YU48855B (en) 2002-06-19
NL980001I2 (en) 1998-05-06
AU646871B2 (en) 1994-03-10
FI960155A7 (en) 1996-01-12

Similar Documents

Publication Publication Date Title
LV10274B (en) Therapeutic heterocyclic compounds
NO962540L (en) Rapamycin derivatives for use as immunosuppressants
IE781878L (en) Imidazole derivatives
ES8401032A1 (en) 1,4-Dihydropyridines, process for their preparation and their application as pharmaceutical preparations.
MY101208A (en) Phenyl-piperazine anti-arrhythmia agents.
FI102069B (en) Process for the preparation of therapeutically useful indole derivatives
IE791004L (en) 1-phenyl-2-aminoethanol derivatives
GR3020848T3 (en) 1,8-Naphthyridin-2-one derivatives
IL107287A (en) Heterocyclic derivatives process for their preparation and pharmaceutical compositions containing some of them
MY117092A (en) Chemotherapeutic pyrrolocarbazole derivatives
IE872588L (en) Compounds
HUT50354A (en) Process for producing new s-adenosylmethionine decarboxilase inhibitors
IL97053A0 (en) Pharmaceutical compositions comprising azapirones for the treatment of sleep apneas
BG95629A (en) Derivatives of 10, 11, 12, 13 - tetrahytdrodesmicozine, method for preparing them, and their use as pharmaceutical preparations
IL103508A (en) Pyrazino £1, 2-a| pyrrolo £2, 1-c| £1, 4| benzodiazepine- 2-alkanoic acid derivatives having anti-allergic and anti-asthmatic activities, their preparation, and pharmaceutical compositions containing them
JPS55104266A (en) Novel pyridone derivative

Legal Events

Date Code Title Description
PC9A Transfer of patents

Free format text: ASTRAZENECA AB,15185 SODERTALJE,SE,20001130

MK9A Expiry of a patent

Effective date: 20130315