KR102072041B1 - 치환된 뉴클레오사이드, 뉴클레오타이드 및 그의 유사체 - Google Patents
치환된 뉴클레오사이드, 뉴클레오타이드 및 그의 유사체 Download PDFInfo
- Publication number
- KR102072041B1 KR102072041B1 KR1020147019834A KR20147019834A KR102072041B1 KR 102072041 B1 KR102072041 B1 KR 102072041B1 KR 1020147019834 A KR1020147019834 A KR 1020147019834A KR 20147019834 A KR20147019834 A KR 20147019834A KR 102072041 B1 KR102072041 B1 KR 102072041B1
- Authority
- KR
- South Korea
- Prior art keywords
- optionally substituted
- delete delete
- alkyl
- compound
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 COCCNC(*)=O Chemical compound COCCNC(*)=O 0.000 description 12
- LSPZPTTYHOSNIJ-FOUBCARRSA-N CC(C)OC(OCOP(OC[C@](C1CC1)([C@H]([C@H]1F)O)O[C@H]1N(C=CC(N)=N1)C1=O)(OCOC(OC(C)C)=O)=O)=O Chemical compound CC(C)OC(OCOP(OC[C@](C1CC1)([C@H]([C@H]1F)O)O[C@H]1N(C=CC(N)=N1)C1=O)(OCOC(OC(C)C)=O)=O)=O LSPZPTTYHOSNIJ-FOUBCARRSA-N 0.000 description 1
- SIXSDZWLJUVNHD-PJQZPIPGSA-N CC[C@@](COP(N[C@@H](C)C(OC1CCCCC1)=O)(N[C@@H](C)C(OC1CCCCC1)=O)=O)([C@H](C1)O)O[C@H]1N(C=CC(N)=N1)C1=O Chemical compound CC[C@@](COP(N[C@@H](C)C(OC1CCCCC1)=O)(N[C@@H](C)C(OC1CCCCC1)=O)=O)([C@H](C1)O)O[C@H]1N(C=CC(N)=N1)C1=O SIXSDZWLJUVNHD-PJQZPIPGSA-N 0.000 description 1
- PHXDQZCLOAZTAX-UHFFFAOYSA-N CCc1cccc(CCC(OC)=O)c1N Chemical compound CCc1cccc(CCC(OC)=O)c1N PHXDQZCLOAZTAX-UHFFFAOYSA-N 0.000 description 1
- HWPZZUQOWRWFDB-UHFFFAOYSA-N CN(C=CC(N)=N1)C1=O Chemical compound CN(C=CC(N)=N1)C1=O HWPZZUQOWRWFDB-UHFFFAOYSA-N 0.000 description 1
- PFIOZJBSESOVGS-UHFFFAOYSA-N CN1N=CC(N)=NC1=O Chemical compound CN1N=CC(N)=NC1=O PFIOZJBSESOVGS-UHFFFAOYSA-N 0.000 description 1
- PESGUQRDJASXOR-UHFFFAOYSA-N C[n]1c(N=CNC2=O)c2nc1 Chemical compound C[n]1c(N=CNC2=O)c2nc1 PESGUQRDJASXOR-UHFFFAOYSA-N 0.000 description 1
- DHNIKYWYTSMDDA-UHFFFAOYSA-N C[n]1c(NC(NC2=O)=O)c2nc1 Chemical compound C[n]1c(NC(NC2=O)=O)c2nc1 DHNIKYWYTSMDDA-UHFFFAOYSA-N 0.000 description 1
- YDBCQGNEXYFIHD-UHFFFAOYSA-N C[n]1nc(C(N)=O)nc1 Chemical compound C[n]1nc(C(N)=O)nc1 YDBCQGNEXYFIHD-UHFFFAOYSA-N 0.000 description 1
- PNPGHDZIIDHMGY-UHFFFAOYSA-N O=P([n]1ncnc1)([n]1ncnc1)[n]1ncnc1 Chemical compound O=P([n]1ncnc1)([n]1ncnc1)[n]1ncnc1 PNPGHDZIIDHMGY-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/127—RNA-directed RNA polymerase (2.7.7.48), i.e. RNA replicase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
- C12Y207/07048—RNA-directed RNA polymerase (2.7.7.48), i.e. RNA replicase
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Virology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Package Frames And Binding Bands (AREA)
- Lighting Device Outwards From Vehicle And Optical Signal (AREA)
- Measurement Of Velocity Or Position Using Acoustic Or Ultrasonic Waves (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161579560P | 2011-12-22 | 2011-12-22 | |
| US61/579,560 | 2011-12-22 | ||
| US201261613836P | 2012-03-21 | 2012-03-21 | |
| US61/613,836 | 2012-03-21 | ||
| PCT/US2012/071063 WO2013096679A1 (en) | 2011-12-22 | 2012-12-20 | Substituted nucleosides, nucleotides and analogs thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20140108287A KR20140108287A (ko) | 2014-09-05 |
| KR102072041B1 true KR102072041B1 (ko) | 2020-01-31 |
Family
ID=48669505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020147019834A Expired - Fee Related KR102072041B1 (ko) | 2011-12-22 | 2012-12-20 | 치환된 뉴클레오사이드, 뉴클레오타이드 및 그의 유사체 |
Country Status (36)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140138977A (ko) * | 2012-03-21 | 2014-12-04 | 앨리오스 바이오파마 인크. | 치환된 뉴클레오사이드, 뉴클레오타이드 및 그의 유사체 |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2812962C (en) | 2010-09-22 | 2020-03-31 | Alios Biopharma, Inc. | Azido nucleosides and nucleotide analogs |
| US8871737B2 (en) | 2010-09-22 | 2014-10-28 | Alios Biopharma, Inc. | Substituted nucleotide analogs |
| EP2655392B1 (en) | 2010-12-22 | 2018-04-18 | Alios Biopharma, Inc. | Cyclic nucleotide analogs |
| MX356509B (es) | 2011-12-22 | 2018-05-30 | Alios Biopharma Inc | Nucleósidos sustituidos, nucleótidos y análogos de los mismos. |
| US8980865B2 (en) | 2011-12-22 | 2015-03-17 | Alios Biopharma, Inc. | Substituted nucleotide analogs |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| EP2828278A4 (en) | 2012-03-21 | 2015-12-09 | Alios Biopharma Inc | PROCESSES FOR PREPARING SUBSTITUTED NUCLEOTIDE ANALOGS |
| CN104321333A (zh) | 2012-03-21 | 2015-01-28 | 沃泰克斯药物股份有限公司 | 硫代氨基磷酸酯核苷酸前药的固体形式 |
| USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| EP2827876A4 (en) | 2012-03-22 | 2015-10-28 | Alios Biopharma Inc | PHARMACEUTICAL COMBINATIONS WITH A THIONUCLEOTIDE ANALOG |
| ES2597757T3 (es) | 2012-05-25 | 2017-01-20 | Janssen Sciences Ireland Uc | Nucleósidos de uracilespirooxetano |
| US9598457B2 (en) | 2012-12-21 | 2017-03-21 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| PE20151433A1 (es) | 2012-12-21 | 2015-10-16 | Alios Biopharma Inc | Nucleosidos sustituidos, nucleotidos y analogos de los mismos |
| AR099632A1 (es) | 2013-04-05 | 2016-08-10 | Alios Biopharma Inc | Tratamiento de una infección viral de hepatitis c, que usa una combinación de compuestos |
| GEP201706793B (en) * | 2013-06-26 | 2017-12-11 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| CA2913206C (en) | 2013-06-26 | 2022-08-02 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| US10435430B2 (en) | 2013-07-31 | 2019-10-08 | Ionis Pharmaceuticals, Inc. | Methods and compounds useful in conditions related to repeat expansion |
| UA117375C2 (uk) | 2013-09-04 | 2018-07-25 | Медівір Аб | Інгібітори полімерази hcv |
| CN104447923B (zh) * | 2013-09-23 | 2018-03-30 | 中国药科大学 | 2’‑脱氧‑2’‑氟‑2’‑甲基核苷衍生物及其制备方法与在制药中的用途 |
| WO2015054465A1 (en) | 2013-10-11 | 2015-04-16 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| WO2015056213A1 (en) | 2013-10-17 | 2015-04-23 | Medivir Ab | Hcv polymerase inhibitors |
| UA119050C2 (uk) * | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
| US10683321B2 (en) | 2013-12-18 | 2020-06-16 | Idenix Pharmaceuticals Llc | 4′-or nucleosides for the treatment of HCV |
| JP6581100B2 (ja) | 2014-02-06 | 2019-09-25 | リボサイエンス・エルエルシー | インフルエンザrna複製の阻害剤としての4’−ジフルオロメチル置換ヌクレオシド誘導体 |
| JP6191989B2 (ja) * | 2014-02-12 | 2017-09-06 | 学校法人東京理科大学 | アデニン誘導体又はその薬理学的に許容しうる塩、その製造方法、及びその用途 |
| EP3160475B1 (en) | 2014-06-24 | 2024-01-03 | Janssen Pharmaceuticals, Inc. | Substituted nucleosides and nucleotides to treat filoviridae infections |
| WO2015200219A1 (en) | 2014-06-24 | 2015-12-30 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| BR112017001162A2 (pt) * | 2014-07-22 | 2017-11-14 | Alios Biopharma Inc | métodos para tratar paramixovírus |
| TWI678369B (zh) * | 2014-07-28 | 2019-12-01 | 美商基利科學股份有限公司 | 用於治療呼吸道合胞病毒感染之噻吩並[3,2-d]嘧啶、呋喃並[3,2-d]嘧啶及吡咯並[3,2-d]嘧啶化合物類 |
| EP3177299A4 (en) * | 2014-08-05 | 2018-04-04 | Alios Biopharma, Inc. | Combination therapy for treating a paramyxovirus |
| TWI673283B (zh) | 2014-08-21 | 2019-10-01 | 美商基利科學股份有限公司 | 2’-氯胺基嘧啶酮及嘧啶二酮核苷類 |
| EP3197457B1 (en) * | 2014-09-26 | 2022-11-09 | Riboscience LLC | 4'-vinyl substituted nucleoside derivatives as inhibitors of respiratory syncytial virus rna replication |
| CA2963686A1 (en) * | 2014-10-08 | 2016-04-14 | Epigenetics Pharma Llc | Silylated pyrimidine prodrugs and methods of their use |
| WO2016069489A1 (en) | 2014-10-28 | 2016-05-06 | Alios Biopharma, Inc. | Methods of preparing substituted nucleoside analogs |
| MA41213A (fr) | 2014-12-19 | 2017-10-24 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
| MA41441A (fr) | 2014-12-19 | 2017-12-12 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
| LT3236972T (lt) * | 2014-12-26 | 2021-11-10 | Emory University | Antivirusiniai n4-hidroksicitidino dariniai |
| EP3268368A4 (en) | 2015-03-11 | 2018-11-14 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
| CN109790143A (zh) | 2016-05-10 | 2019-05-21 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| EP3454862B1 (en) | 2016-05-10 | 2024-09-11 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
| CN109641874A (zh) | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
| WO2017197055A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| CN107501247A (zh) * | 2016-06-14 | 2017-12-22 | 安徽贝克联合制药有限公司 | 一种尿嘧啶核苷类衍生物的制备方法 |
| US10202412B2 (en) | 2016-07-08 | 2019-02-12 | Atea Pharmaceuticals, Inc. | β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections |
| TW201811339A (zh) | 2016-08-12 | 2018-04-01 | 美商艾洛斯生物製藥公司 | 經取代之核苷、核苷酸及其類似物 |
| EP3510040A4 (en) | 2016-09-09 | 2020-06-03 | Calithera Biosciences, Inc. | ECTONUCLEOTIDASE INHIBITORS AND METHODS OF USE |
| WO2018081449A1 (en) | 2016-10-27 | 2018-05-03 | Alios Biopharma, Inc. | Methods for treating respiratory syncytial virus infection |
| CN110769822A (zh) | 2017-06-20 | 2020-02-07 | C4医药公司 | 用于蛋白降解的n/o-连接的降解决定子和降解决定子体 |
| EP3661513A4 (en) | 2017-07-31 | 2021-07-14 | January Therapeutics, Inc. | ORGANOPHOSPHATE DERIVATIVES |
| LT3706762T (lt) | 2017-12-07 | 2024-12-27 | Emory University | N4-hidroksicitidinas ir jo dariniai bei susiję naudojimo prieš virusus būdai |
| AU2018386222B2 (en) * | 2017-12-15 | 2023-04-20 | Janssen Biotech, Inc. | Cyclic dinucleotides as sting agonists |
| MA55200A (fr) | 2019-03-06 | 2022-01-12 | Glaxosmithkline Ip No 2 Ltd | Composés utiles dans la thérapie du vih |
| WO2021011572A1 (en) * | 2019-07-18 | 2021-01-21 | The Board Of Trustees Of The Leland Stanford Junior University | Enhancing the antiviral efficacy of rna virus inhibition by combination with modulators of pyrimidine metabolism |
| US11708637B2 (en) * | 2019-08-13 | 2023-07-25 | The Regents Of The University Of California | Methods of supporting a graphene sheet disposed on a frame support |
| AR121356A1 (es) | 2020-02-18 | 2022-05-11 | Gilead Sciences Inc | Compuestos antivirales |
| TWI883391B (zh) | 2020-02-18 | 2025-05-11 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| TWI874791B (zh) | 2020-02-18 | 2025-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| TWI845826B (zh) | 2020-03-20 | 2024-06-21 | 美商基利科學股份有限公司 | 4'-c-經取代-2-鹵基-2'-去氧腺苷核苷之前藥及其製造與使用方法 |
| WO2021195011A1 (en) * | 2020-03-24 | 2021-09-30 | Intrinsic Medicine, Inc. | Immunomodulatory oligosaccharides for the treatment of viral respiratory infection |
| CN111892636A (zh) * | 2020-08-07 | 2020-11-06 | 山东大学 | 一种阿兹夫定的合成方法 |
| PL4200301T3 (pl) | 2020-08-24 | 2025-06-09 | Gilead Sciences, Inc. | Związki fosfolipidowe i ich zastosowania |
| TWI811812B (zh) | 2020-10-16 | 2023-08-11 | 美商基利科學股份有限公司 | 磷脂化合物及其用途 |
| US12274700B1 (en) | 2020-10-30 | 2025-04-15 | Accencio LLC | Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors |
| CN112279877B (zh) * | 2020-12-15 | 2021-08-06 | 南京颐媛生物医学研究院有限公司 | 一种核苷磷酸酯及其合成方法 |
| EP4323362B1 (en) | 2021-04-16 | 2025-05-07 | Gilead Sciences, Inc. | Methods of preparing carbanucleosides using amides |
| CA3228162A1 (en) * | 2021-08-18 | 2023-02-23 | Gilead Sciences, Inc. | Phospholipid compounds and methods of making and using the same |
| PE20250684A1 (es) | 2022-03-15 | 2025-03-04 | Rome Therapeutics Inc | Compuestos y metodos para el tratamiento de enfermedades |
| WO2024015916A2 (en) * | 2022-07-13 | 2024-01-18 | Thomas Jefferson University | 4'-alkyne-2'-deoxycytidine-based compounds and anti-cancer uses thereof |
| WO2024159117A1 (en) * | 2023-01-26 | 2024-08-02 | The Regents Of The University Of California | Antiviral prodrugs, intermediate-and long-acting formulations, and methods |
| CN116425703B (zh) * | 2023-03-27 | 2024-05-31 | 浙大宁波理工学院 | 一种饱和环醚类化合物c2位环外甲基氘代的方法 |
Family Cites Families (306)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH563405A5 (enExample) | 1971-09-10 | 1975-06-30 | Duschinsky Robert Dr Schweiz I | |
| IL51342A (en) | 1977-01-27 | 1980-11-30 | Abic Ltd | Ethoxyquin derivatives,their preparation and pharmaceutical and veterinary compositions comprising them |
| US4230698A (en) | 1978-05-12 | 1980-10-28 | Research Corporation | 2-Substituted arabinofuranosyl nucleosides and nucleotides |
| US4211773A (en) | 1978-10-02 | 1980-07-08 | Sloan Kettering Institute For Cancer Research | 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides |
| AU5118979A (en) | 1978-10-16 | 1980-04-24 | Takeda Chemical Industries Ltd. | 2,6-diaminoebularines |
| US4652554A (en) | 1982-02-22 | 1987-03-24 | St. Jude Children's Research Hospital | Nitro-substituted 1-β-D-arabinofuranosylcytosines |
| JPS60228497A (ja) | 1984-04-27 | 1985-11-13 | Sumitomo Chem Co Ltd | 新規なアデニル酸誘導体 |
| US4713383A (en) | 1984-10-01 | 1987-12-15 | Ciba-Geigy Corporation | Triazoloquinazoline compounds, and their methods of preparation, pharmaceutical compositions, and uses |
| US4626526A (en) | 1984-10-26 | 1986-12-02 | Warner-Lambert Company | (S)-N6 -2-hydroxypropyladenosines |
| US4855304A (en) | 1985-01-10 | 1989-08-08 | Repligen Corporation | Dinucleoside pyrophosphates and pyrophosphate homologs as plant antivirals |
| JPS61219478A (ja) | 1985-03-26 | 1986-09-29 | Potsupuribetsuto Fastener Kk | 溶接検知方法及び装置 |
| PL144471B1 (en) | 1985-04-22 | 1988-05-31 | Polska Akad Nauk Centrum | Method of obtaining novel 3',5'-cyclic adensine dithiophosphate |
| US4762823A (en) | 1985-10-16 | 1988-08-09 | Sloan-Kettering Institute For Cancer Research | Nucleosides of 5-monofluoromethyluracil and 5-difluoromethyluracil |
| US4797495A (en) | 1985-11-22 | 1989-01-10 | Burroughs Wellcome Co. | Benzo[c]carbazole propanediol compound and salts thereof |
| NL8700865A (nl) | 1986-04-14 | 1987-11-02 | Shell Int Research | Gehalogeneerde heterocyclische etherherbiciden. |
| WO1988003147A1 (en) | 1986-10-31 | 1988-05-05 | Warner-Lambert Company | Selected n6-substituted adenosines having selective a2 binding activity |
| SU1417408A1 (ru) | 1986-12-02 | 1995-09-10 | Г.П. Акулов | Способ получения меченного тритием дезоксиаденозина |
| JPH0699467B2 (ja) | 1987-03-04 | 1994-12-07 | ヤマサ醤油株式会社 | 2▲’▼−デオキシ−2▲’▼(s)−アルキルピリミジンヌクレオシド誘導体 |
| JP2828642B2 (ja) | 1987-06-24 | 1998-11-25 | ハワード フローレイ インスティテュト オブ イクスペリメンタル フィジオロジー アンド メディシン | ヌクレオシド誘導体 |
| DE3730542A1 (de) | 1987-09-11 | 1989-04-06 | Hoechst Ag | Arzneimittel mit einem gehalt an bestimmten 6-mercaptopurin-derivaten, verwendung dieser 6-mercaptopurin-derivate, verfahren zur herstellung der arzneimittel sowie einige neue 6-mercaptopurin-derivate und verfahren zu deren herstellung |
| US4880784A (en) | 1987-12-21 | 1989-11-14 | Brigham Young University | Antiviral methods utilizing ribofuranosylthiazolo[4,5-d]pyrimdine derivatives |
| HU204843B (en) | 1988-09-27 | 1992-02-28 | Merrell Dow Pharma | Process for producing 2'-halogen-methylidene adenosine derivatives and pharmaceutical compositions comprising same |
| ZA898567B (en) | 1988-11-15 | 1990-08-29 | Merrell Dow Pharma | Novel 2'-halomethylidene,2'-ethenylidene and 2'-ethynyl cytidine,uridine and guanosine derivatives |
| US5616702A (en) | 1988-11-15 | 1997-04-01 | Merrell Pharmaceuticals Inc. | 2-'-ethenylidene cytidine, uridine and guanosine derivatives |
| MX9203459A (es) | 1988-11-15 | 1992-08-01 | Merrell Pharma Inc | Nuevos derivados de 2'-halometilideno, 2'-etenilideno y 2'-etinilcitidina, uridina y guanosina. |
| KR900007863A (ko) | 1988-11-21 | 1990-06-02 | 원본미기재 | 향비루스제 |
| SE462497B (sv) | 1988-11-30 | 1990-07-02 | Clas Fredrik Runesson Kaelland | Saett foer att aktivitetsbestaemma polymeraser |
| FR2642074B1 (fr) | 1989-01-20 | 1994-04-29 | Oris Ind | Derives de molecules polyhydroxylees permettant l'introduction d'au moins une ramification dans un oligonucleotide |
| US5296348A (en) | 1989-05-16 | 1994-03-22 | The Wistar Institute Of Anatomy And Biology | Methods for screening monoclonal antibodies for therapeutic use |
| DE3916871A1 (de) | 1989-05-24 | 1990-11-29 | Boehringer Mannheim Gmbh | Modifiziertes phosphoramidit-verfahren zur herstellung von modifizierten nukleinsaeuren |
| DE3924424A1 (de) | 1989-07-24 | 1991-01-31 | Boehringer Mannheim Gmbh | Nucleosid-derivate, verfahren zu deren herstellung, deren verwendung als arzneimittel sowie deren verwendung bei der nucleinsaeure-sequenzierung |
| JPH0699711B2 (ja) | 1989-07-25 | 1994-12-07 | 花王株式会社 | 液体洗浄剤組成物 |
| US5674998A (en) | 1989-09-15 | 1997-10-07 | Gensia Inc. | C-4' modified adenosine kinase inhibitors |
| DE69034150T2 (de) | 1989-10-24 | 2005-08-25 | Isis Pharmaceuticals, Inc., Carlsbad | 2'-Modifizierte Oligonukleotide |
| US5852188A (en) | 1990-01-11 | 1998-12-22 | Isis Pharmaceuticals, Inc. | Oligonucleotides having chiral phosphorus linkages |
| WO1991010671A1 (en) | 1990-01-11 | 1991-07-25 | Isis Pharmaceuticals, Inc. | Compositions and methods for detecting and modulating rna activity and gene expression |
| US5514786A (en) | 1990-01-11 | 1996-05-07 | Isis Pharmaceuticals, Inc. | Compositions for inhibiting RNA activity |
| US5578718A (en) | 1990-01-11 | 1996-11-26 | Isis Pharmaceuticals, Inc. | Thiol-derivatized nucleosides |
| US5670633A (en) | 1990-01-11 | 1997-09-23 | Isis Pharmaceuticals, Inc. | Sugar modified oligonucleotides that detect and modulate gene expression |
| US5457191A (en) | 1990-01-11 | 1995-10-10 | Isis Pharmaceuticals, Inc. | 3-deazapurines |
| CA2037767A1 (en) | 1990-03-23 | 1991-09-24 | Mark D. Wittman | Conversion of amines to hydroxylamines |
| US5658731A (en) | 1990-04-09 | 1997-08-19 | Europaisches Laboratorium Fur Molekularbiologie | 2'-O-alkylnucleotides as well as polymers which contain such nucleotides |
| US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| US5478813A (en) | 1990-05-11 | 1995-12-26 | Banyu Pharmaceutical Co., Ltd. | Antitumor substance BE-13793C derivatives |
| AU7623991A (en) * | 1990-05-17 | 1991-11-21 | Syntex (U.S.A.) Inc. | Antiviral agents |
| GB9012899D0 (en) | 1990-06-09 | 1990-08-01 | Wellcome Found | Anti-hbv pyrimidine nucleoside |
| JP2559917B2 (ja) | 1990-06-15 | 1996-12-04 | 三共株式会社 | ピリミジンヌクレオシド誘導体 |
| DE4019892A1 (de) | 1990-06-22 | 1992-01-02 | Boehringer Ingelheim Kg | Neue xanthinderivate |
| MY106399A (en) | 1990-07-24 | 1995-05-30 | Pfizer | Cephalosporins and homologeus, preparation and pharmaceutical composition |
| US5138045A (en) | 1990-07-27 | 1992-08-11 | Isis Pharmaceuticals | Polyamine conjugated oligonucleotides |
| US5378825A (en) | 1990-07-27 | 1995-01-03 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs |
| US5602240A (en) | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
| US5777100A (en) | 1990-08-10 | 1998-07-07 | Gensia Inc. | AICA riboside analogs |
| IL99125A0 (en) | 1990-08-10 | 1992-07-15 | Gensia Pharma | Derivatives of imidazole analog of aica riboside and their use |
| US6262241B1 (en) | 1990-08-13 | 2001-07-17 | Isis Pharmaceuticals, Inc. | Compound for detecting and modulating RNA activity and gene expression |
| US5420115A (en) * | 1990-09-10 | 1995-05-30 | Burroughs Wellcome Co. | Method for the treatment of protoza infections with 21 -deoxy-21 -fluoropurine nucleosides |
| US5432272A (en) | 1990-10-09 | 1995-07-11 | Benner; Steven A. | Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases |
| AU665184B2 (en) | 1991-01-23 | 1995-12-21 | Gensia, Inc. | Adenosine kinase inhibitors |
| US5171849A (en) | 1991-04-19 | 1992-12-15 | The Ohio State University Research Foundation | 2' and 3' Carboranyl uridines and their diethyl ether adducts |
| US5446031A (en) | 1991-04-24 | 1995-08-29 | Yamasa Shuyu Kabushiki Kaisha | 1-β-D-arabinofuranosyl-(E)-5-(2-halogenovinyl)uracil derivatives |
| US5192764A (en) | 1991-05-30 | 1993-03-09 | Research Foundation Of State Of N.Y. | Pyrazinone n-oxide nucleosides and analogs thereof |
| GB9111580D0 (en) | 1991-05-30 | 1991-07-24 | Wellcome Found | Nucleoside derivative |
| US5508407A (en) | 1991-07-10 | 1996-04-16 | Eli Lilly And Company | Retroviral protease inhibitors |
| JPH0551395A (ja) | 1991-08-21 | 1993-03-02 | Teijin Ltd | ペンタフルオロプロピオニル化(デオキシ)ウリジンおよびそれを用いる(デオキシ)ウリジンの測定方法 |
| US5268376A (en) | 1991-09-04 | 1993-12-07 | Minnesota Mining And Manufacturing Company | 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
| DE4131579A1 (de) | 1991-09-23 | 1993-03-25 | Boehringer Mannheim Gmbh | Thiadiazolo(4,3-a)pyridinderivate, verfahren zu ihrer herstellung und diese enthaltenden arzneimittel |
| CA2079413C (en) | 1991-09-30 | 2003-09-09 | Masakatsu Kaneko | Pyrimidine nucleoside derivatives having anti-tumor activity, their preparation and use |
| US6335434B1 (en) | 1998-06-16 | 2002-01-01 | Isis Pharmaceuticals, Inc., | Nucleosidic and non-nucleosidic folate conjugates |
| US6235887B1 (en) | 1991-11-26 | 2001-05-22 | Isis Pharmaceuticals, Inc. | Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines |
| DE637965T1 (de) | 1991-11-26 | 1995-12-14 | Gilead Sciences Inc | Gesteigerte bildung von triple- und doppelhelices aus oligomeren mit modifizierten pyrimidinen. |
| IT1249732B (it) | 1991-11-26 | 1995-03-09 | Angeletti P Ist Richerche Bio | Oligonucleotidi antisenso. |
| FR2684997A1 (fr) | 1991-12-12 | 1993-06-18 | Centre Nat Rech Scient | Derives de la 9-(beta-d-xylofurannosyl) adenine et de la 1-(beta-d-xylofurannosyl) cytosine, leur preparation et leur application en therapeutique. |
| FR2688003B1 (fr) | 1992-02-28 | 1995-06-30 | Univ Limoges | Derives de nucleosides, leur preparation et leurs applications biologiques. |
| US5543507A (en) | 1992-03-05 | 1996-08-06 | Isis Pharmaceuticals, Inc. | Covalently cross-linked oligonucleotides |
| DK0664708T3 (da) | 1992-04-10 | 1998-11-02 | Merrell Pharma Inc | Metode til behandling af cancer ved kombinationsbehandling med 2'-halogenmethylidenderivater og et S-fase- eller M-fase-spe |
| IL105325A (en) | 1992-04-16 | 1996-11-14 | Minnesota Mining & Mfg | Immunogen/vaccine adjuvant composition |
| US5808139A (en) | 1992-04-21 | 1998-09-15 | Ligand Pharmaceuticals Incorporated | Non-steroid progesterone receptor agonist and antagonist and compounds and methods |
| DE69306570T2 (de) | 1992-05-12 | 1997-04-10 | Merrell Pharmaceuticals Inc N | Verfahren zur herstellung von ribonukleotid-reduktasehemmern |
| US5625056A (en) | 1992-05-26 | 1997-04-29 | Biolog Life Science Institute | Derivatives of cyclic guanosine-3',5'-monophosphorothioate |
| DE4217679C2 (de) | 1992-05-26 | 1998-02-19 | Genieser Hans Gottfried Dr | Cyclische Guanosin-3',5'-phosphorothioat-Derivate |
| EP1223173B1 (en) | 1992-07-23 | 2005-07-13 | Isis Pharmaceuticals, Inc. | Novel 2'-O-alkyl nucleosides and phosphoramidites processes for the preparation and uses thereof |
| CA2159632A1 (en) | 1993-03-31 | 1994-10-13 | Ashis Kumar Saha | Novel 5'-substituted nucleosides and oligomers produced therefrom |
| CA2171743C (en) | 1993-09-17 | 2007-11-20 | Norbert W. Bischofberger | Nucleotide analogs |
| DE4341161A1 (de) | 1993-12-02 | 1995-06-08 | Michael Prof Dr Zeppezauer | Membrangängiger Wirkstoff zur Störung der DNA-Biosynthese |
| US5446137B1 (en) | 1993-12-09 | 1998-10-06 | Behringwerke Ag | Oligonucleotides containing 4'-substituted nucleotides |
| JPH07242544A (ja) | 1994-03-01 | 1995-09-19 | Takeda Chem Ind Ltd | 抗腫瘍剤 |
| US5681940A (en) | 1994-11-02 | 1997-10-28 | Icn Pharmaceuticals | Sugar modified nucleosides and oligonucleotides |
| US6004939A (en) | 1995-07-06 | 1999-12-21 | Ctrc Research Foundation Board Of Regents | Methods for modulation and inhibition of telomerase |
| PL187439B1 (pl) | 1996-01-23 | 2004-07-30 | Icn Pharmaceuticals | Zastosowanie rybawiryny |
| JPH09328497A (ja) | 1996-04-12 | 1997-12-22 | Yamasa Shoyu Co Ltd | 4’−フルオロメチルヌクレオシド |
| DE69729887T2 (de) | 1996-10-16 | 2005-07-28 | ICN Pharmaceuticals, Inc., Costa Mesa | Purin-L-Nukleoside, Analoga und deren Verwendung |
| AU738170B2 (en) | 1996-10-16 | 2001-09-13 | Icn Pharmaceuticals, Inc. | Monocyclic L-nucleosides, analogs and uses thereof |
| US20030064945A1 (en) | 1997-01-31 | 2003-04-03 | Saghir Akhtar | Enzymatic nucleic acid treatment of diseases or conditions related to levels of epidermal growth factor receptors |
| AU9063398A (en) | 1997-09-12 | 1999-04-05 | Exiqon A/S | Oligonucleotide analogues |
| US20030203862A1 (en) | 1998-03-26 | 2003-10-30 | Miraglia Loren J. | Antisense modulation of MDM2 expression |
| US6127121A (en) | 1998-04-03 | 2000-10-03 | Epoch Pharmaceuticals, Inc. | Oligonucleotides containing pyrazolo[3,4-D]pyrimidines for hybridization and mismatch discrimination |
| AU4322799A (en) | 1998-05-28 | 1999-12-13 | Incara Pharmaceuticals Corp. | Carbohydrate-based scaffold compounds, combinatorial libraries and methods for their construction |
| DE19855963A1 (de) | 1998-12-04 | 2000-06-08 | Herbert Schott | Amphiphile Glycerylnucleotide, Verfahren zu ihrer Herstellung und ihre Verwendung |
| HK1048639A1 (zh) * | 1999-03-18 | 2003-04-11 | 埃克西库恩公司 | 木-lna类似物 |
| AU776362B2 (en) * | 1999-05-04 | 2004-09-09 | Roche Innovation Center Copenhagen A/S | L-ribo-LNA analogues |
| JP4076114B2 (ja) | 1999-05-12 | 2008-04-16 | ヤマサ醤油株式会社 | 4’−c−エチニルプリンヌクレオシド化合物 |
| ES2207504T3 (es) | 1999-05-12 | 2004-06-01 | Yamasa Corporation | Nucleosidos 4'-c-etinilpurina. |
| US6831069B2 (en) | 1999-08-27 | 2004-12-14 | Ribapharm Inc. | Pyrrolo[2,3-d]pyrimidine nucleoside analogs |
| JP2003511454A (ja) | 1999-08-27 | 2003-03-25 | アイ・シー・エヌ・フアーマシユーテイカルズ・インコーポレイテツド | ピロロ[2,3−d]ピリミジンヌクレオシド類似化合物 |
| IL133680A0 (en) | 1999-09-10 | 2001-04-30 | Can Fite Technologies Ltd | Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist |
| BR0016415A (pt) | 1999-12-16 | 2002-12-24 | Alcon Inc | Inibidores de adenosina cinase para o tratamento de dano retinal e de nervo ótico |
| US6495677B1 (en) | 2000-02-15 | 2002-12-17 | Kanda S. Ramasamy | Nucleoside compounds |
| US6815542B2 (en) | 2000-06-16 | 2004-11-09 | Ribapharm, Inc. | Nucleoside compounds and uses thereof |
| UA72612C2 (en) | 2000-07-06 | 2005-03-15 | Pyrido[2.3-d]pyrimidine and pyrimido[4.5-d]pyrimidine nucleoside analogues, prodrugs and method for inhibiting growth of neoplastic cells | |
| JP2002322192A (ja) * | 2000-08-10 | 2002-11-08 | Sankyo Co Ltd | 2’−o,4’−c−架橋ヌクレオシドトリリン酸体 |
| WO2002031176A1 (fr) | 2000-10-12 | 2002-04-18 | Mitsui Chemicals, Inc. | Procédé permettant la production de nucléosides |
| JP2004313002A (ja) | 2000-10-12 | 2004-11-11 | Mitsui Chemicals Inc | ヌクレオシドの製造方法 |
| CA2426187C (en) | 2000-10-18 | 2011-08-16 | Pharmasset Limited | Modified nucleosides for the treatment of viral infections and abnormal cellular proliferation |
| AU2002219497B2 (en) | 2001-01-16 | 2004-08-26 | Can-Fite Biopharma Ltd. | Use of an adenosine A3 receptor agonist for inhibition of viral replication |
| CN1267446C (zh) | 2001-01-22 | 2006-08-02 | 默克公司 | 作为依赖于rna的rna病毒聚合酶的抑制剂的核苷衍生物 |
| JP2002302498A (ja) | 2001-04-03 | 2002-10-18 | Mitsui Chemicals Inc | ヌクレオシドの工業的な製造法 |
| US20040204481A1 (en) | 2001-04-12 | 2004-10-14 | Pnina Fishman | Activation of natural killer cells by adenosine A3 receptor agonists |
| US20030175950A1 (en) | 2001-05-29 | 2003-09-18 | Mcswiggen James A. | RNA interference mediated inhibition of HIV gene expression using short interfering RNA |
| WO2003070912A2 (en) | 2001-06-06 | 2003-08-28 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF EPIDERMAL GROWTH FACTOR RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| EP1390472A4 (en) | 2001-05-29 | 2004-11-17 | Sirna Therapeutics Inc | NUCLEIC ACID TREATMENT OF DISEASES OR SIDES RELATED TO RAS, HER2 AND HIV LEVELS |
| GB0114286D0 (en) * | 2001-06-12 | 2001-08-01 | Hoffmann La Roche | Nucleoside Derivatives |
| JP2003012690A (ja) | 2001-07-03 | 2003-01-15 | Mitsui Chemicals Inc | 置換イミダゾール誘導体又は置換ベンズイミダゾール誘導体を用いたヌクレオチドの製造法 |
| JP2003055392A (ja) | 2001-08-08 | 2003-02-26 | Mitsui Chemicals Inc | 1−リン酸化糖の製造法並びにヌクレオシドの製造法 |
| BR0211900A (pt) * | 2001-08-14 | 2004-08-24 | Toyama Chemical Co Ltd | Método para inibição do desenvolvimento de vìrus e/ou virucida, análogos de nucleotìdeo de pirazina e de nucleosìdeo de pirazina, precursor do inibidor da polimerase de rna, inibidor da polimerase de rna, método para tratar pacientes infectados por vìrus, e, usos de um análogo de nucleotìdeo de pirazina ou um sal deste e de um análogo de nucleosìdeo de pirazina ou um sal deste |
| US6962991B2 (en) | 2001-09-12 | 2005-11-08 | Epoch Biosciences, Inc. | Process for the synthesis of pyrazolopyrimidines |
| JP2005504087A (ja) | 2001-09-28 | 2005-02-10 | イデニクス(ケイマン)リミテツド | 4’が修飾されたヌクレオシドを使用するc型肝炎ウイルス治療のための方法および組成物 |
| WO2003026675A1 (en) | 2001-09-28 | 2003-04-03 | Idenix (Cayman) Limited | Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside |
| US7037718B2 (en) | 2001-10-26 | 2006-05-02 | Cornell Research Foundation, Inc. | Mutant purine nucleoside phosphorylase proteins and cellular delivery thereof |
| AU2002351077A1 (en) | 2001-11-05 | 2003-05-19 | Exiqon A/S | Oligonucleotides modified with novel alpha-l-rna analogues |
| US7125982B1 (en) | 2001-12-05 | 2006-10-24 | Frayne Consultants | Microbial production of nuclease resistant DNA, RNA, and oligo mixtures |
| US20070032448A1 (en) * | 2002-01-17 | 2007-02-08 | Zhi Hong | Sugar modified nucleosides as viral replication inhibitors |
| WO2003062256A1 (en) | 2002-01-17 | 2003-07-31 | Ribapharm Inc. | 2'-beta-modified-6-substituted adenosine analogs and their use as antiviral agents |
| JP2005524662A (ja) | 2002-02-28 | 2005-08-18 | ビオタ インコーポレーティッド | ヌクレオシド5’−一リン酸模倣物およびこれらのプロドラッグ |
| AU2003217863B9 (en) * | 2002-02-28 | 2009-10-29 | Biota Scientific Management Pty Ltd | Nucleotide mimics and their prodrugs |
| TW200403058A (en) | 2002-04-19 | 2004-03-01 | Bristol Myers Squibb Co | Heterocyclo inhibitors of potassium channel function |
| JP2003310293A (ja) | 2002-04-26 | 2003-11-05 | Mitsui Chemicals Inc | ヌクレオシド化合物の製造法 |
| DK1501848T3 (da) | 2002-05-08 | 2007-10-22 | Santaris Pharma As | Syntese af låst nukleinsyrederivater |
| US7569575B2 (en) | 2002-05-08 | 2009-08-04 | Santaris Pharma A/S | Synthesis of locked nucleic acid derivatives |
| US20040014957A1 (en) | 2002-05-24 | 2004-01-22 | Anne Eldrup | Oligonucleotides having modified nucleoside units |
| WO2003104250A1 (en) | 2002-06-07 | 2003-12-18 | Kylix, B. V. | New compounds for modulating the activity of exchange proteins directly activated by camp (epacs) |
| AU2003248748A1 (en) | 2002-06-28 | 2004-01-19 | Idenix (Cayman) Limited | 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| KR20050055630A (ko) | 2002-06-28 | 2005-06-13 | 이데닉스 (케이만) 리미티드 | 플라비비리다에 감염 치료를 위한 1'-, 2'- 및 3'-변형된뉴클레오시드 유도체 |
| PT1523489E (pt) | 2002-06-28 | 2014-06-24 | Centre Nat Rech Scient | Profármacos de nucleósido modificado em 2' e 3' para tratamento de infecções por flaviridae |
| AU2003259735A1 (en) | 2002-08-08 | 2004-02-25 | Sirna Therapeutics, Inc. | Small-mer compositions and methods of use |
| US7094768B2 (en) | 2002-09-30 | 2006-08-22 | Genelabs Technologies, Inc. | Nucleoside derivatives for treating hepatitis C virus infection |
| AU2003274652A1 (en) | 2002-10-23 | 2004-05-13 | Obetherapy Biotechnology | Compounds, compositions and methods for modulating fat metabolism |
| US20040229840A1 (en) | 2002-10-29 | 2004-11-18 | Balkrishen Bhat | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase |
| RU2005121904A (ru) | 2002-12-12 | 2006-01-20 | Айденикс (Кайман) Лимитед (Ky) | Способ получения 2`-разветвленных нуклеозидов |
| US7393954B2 (en) | 2002-12-12 | 2008-07-01 | Reliable Biopharmaceutical Corporation | Process for the production of pentostatin aglycone and pentostatin |
| US7002006B2 (en) | 2003-02-12 | 2006-02-21 | Isis Pharmaceuticals, Inc. | Protection of nucleosides |
| CA2514466C (en) * | 2003-02-19 | 2015-05-26 | Yale University | Anti-viral nucleoside analogs and methods for treating viral infections, especially hiv infections |
| WO2004080466A1 (en) | 2003-03-07 | 2004-09-23 | Ribapharm Inc. | Cytidine analogs and methods of use |
| WO2004091499A2 (en) | 2003-04-09 | 2004-10-28 | Neose Technologies, Inc. | Intracellular formation of peptide conjugates |
| US20040259934A1 (en) | 2003-05-01 | 2004-12-23 | Olsen David B. | Inhibiting Coronaviridae viral replication and treating Coronaviridae viral infection with nucleoside compounds |
| US20040229839A1 (en) | 2003-05-14 | 2004-11-18 | Biocryst Pharmaceuticals, Inc. | Substituted nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases |
| WO2005020884A2 (en) | 2003-05-14 | 2005-03-10 | Idenix (Cayman) Limited | Nucleosides for treatment of infection by corona viruses, toga viruses and picorna viruses |
| WO2005020885A2 (en) | 2003-05-21 | 2005-03-10 | Isis Pharmaceuticals, Inc. | Compositions and methods for the treatment of severe acute respiratory syndrome (sars) |
| WO2004106356A1 (en) | 2003-05-27 | 2004-12-09 | Syddansk Universitet | Functionalized nucleotide derivatives |
| DE602004029904D1 (de) | 2003-08-27 | 2010-12-16 | Biota Scient Management | Neue tricyclische nukleoside oder nukleotide als therapeutische mittel |
| PE20050469A1 (es) | 2003-09-18 | 2005-09-10 | Lilly Co Eli | Modulacion de la expresion de eif4e |
| JP2007508314A (ja) | 2003-10-08 | 2007-04-05 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | ピロバレロン類縁体及びそれらの治療的使用 |
| DE10348044A1 (de) | 2003-10-15 | 2005-05-19 | Imtm Gmbh | Duale Alanyl-Aminopeptidase- und Dipeptidylpeptidase IV-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
| US7144868B2 (en) | 2003-10-27 | 2006-12-05 | Genelabs Technologies, Inc. | Nucleoside compounds for treating viral infections |
| EP1725572B1 (de) | 2003-11-05 | 2017-05-31 | AGCT GmbH | Makromolekulare nukleotidverbindungen und methoden zu deren anwendung |
| EP1699459B1 (en) | 2003-12-29 | 2007-06-06 | Can-Fite Biopharma Ltd. | Method for treatment of multiple sclerosis |
| DE102004009704A1 (de) | 2004-02-27 | 2005-09-15 | Dmitry Cherkasov | Makromolekulare Nukleotidverbindungen und Methoden zu deren Anwendung |
| GB0413726D0 (en) | 2004-06-18 | 2004-07-21 | Lauras As | Compounds |
| US20060040944A1 (en) | 2004-06-23 | 2006-02-23 | Gilles Gosselin | 5-Aza-7-deazapurine derivatives for treating Flaviviridae |
| EP1778239B1 (en) | 2004-07-28 | 2013-08-21 | Can-Fite Biopharma Ltd. | Adenosine a3 receptor agonists for the treatment of dry eye disorders including sjogren's syndrome |
| US7825102B2 (en) | 2004-07-28 | 2010-11-02 | Can-Fite Biopharma Ltd. | Treatment of dry eye conditions |
| US7608594B2 (en) | 2004-11-03 | 2009-10-27 | University Of Kansas | Novobiocin analogues as anticancer agents |
| US7622451B2 (en) | 2004-11-03 | 2009-11-24 | University Of Kansas | Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders |
| WO2006097320A2 (de) | 2005-03-17 | 2006-09-21 | Genovoxx Gmbh | Makromolekulare nukleotidverbindungen und methoden zu deren anwendung |
| WO2006048884A1 (en) | 2004-11-08 | 2006-05-11 | Can-Fite Biopharma Ltd. | Therapeutic treatment of accelerated bone resorption |
| JP2006131596A (ja) | 2004-11-09 | 2006-05-25 | Univ Nagoya | ヌクレオチド及びその誘導体の製造方法 |
| CA2589935A1 (en) * | 2004-12-09 | 2006-06-15 | Regents Of The University Of Minnesota | Nucleosides with antiviral and anticancer activity |
| WO2006063717A2 (en) | 2004-12-16 | 2006-06-22 | Febit Biotech Gmbh | Polymerase-independent analysis of the sequence of polynucleotides |
| SI1848718T1 (sl) | 2005-02-04 | 2012-12-31 | Millennium Pharmaceuticals, Inc. | Inhibitorji E1 aktivacijskih enzimov |
| CA2600886A1 (en) | 2005-03-08 | 2006-09-14 | Biota Scientific Management Pty Ltd. | Bicyclic nucleosides and nucleotides as therapeutic agents |
| JP2006248949A (ja) | 2005-03-09 | 2006-09-21 | Univ Nagoya | ヌクレオシド誘導体、ヌクレオチド誘導体及びそれらの製造方法 |
| US20100279974A1 (en) | 2005-03-09 | 2010-11-04 | Claire Pierra | Nucleosides With Non-Natural Bases as Anti-Viral Agents |
| US7250416B2 (en) | 2005-03-11 | 2007-07-31 | Supergen, Inc. | Azacytosine analogs and derivatives |
| US20060229265A1 (en) | 2005-03-30 | 2006-10-12 | Sirtris Pharmaceuticals, Inc. | Nicotinamide riboside and analogues thereof |
| WO2006116512A1 (en) | 2005-04-26 | 2006-11-02 | The Board Of Trustees Of The University Of Illinois, Urbana, Il | Nucleoside compounds and methods of use thereof |
| WO2007006544A2 (en) | 2005-07-12 | 2007-01-18 | Vrije Universiteit Brussel | Cyclic adenosine monophosphate compounds for the treatment of immune-related disorders |
| WO2007020018A1 (en) | 2005-08-12 | 2007-02-22 | Universite Libre De Bruxelles | Use of purinergic and pyrimidinergic receptor agonists for dendritic cells based immunotherapies |
| CN101287472B (zh) * | 2005-08-15 | 2011-10-12 | 弗·哈夫曼-拉罗切有限公司 | 抗病毒的4'-取代前核苷酸的氨基磷酸酯类化合物 |
| WO2007038860A2 (en) | 2005-10-03 | 2007-04-12 | University Health Network | Odcase inhibitors as anti-virals and antibiotics |
| CN101304977B (zh) | 2005-11-09 | 2014-08-13 | 东曹株式会社 | 具有全氟烷基的核酸碱类和其制备方法 |
| CN101410407A (zh) | 2006-04-03 | 2009-04-15 | 阿斯利康(瑞典)有限公司 | 取代腺嘌呤及其应用 |
| WO2007149554A2 (en) | 2006-06-22 | 2007-12-27 | The Johns Hopkins University | Methods for restoring neural function |
| GB0614947D0 (en) | 2006-07-27 | 2006-09-06 | Isis Innovation | Epitope reduction therapy |
| CA2659894C (en) | 2006-08-08 | 2018-03-27 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of e1 activating enzymes |
| DE102006037786A1 (de) | 2006-08-11 | 2008-03-20 | Resprotect Gmbh | Nukleoside, diese enthaltendes Arzneimittel und deren Verwendung |
| GB0618235D0 (en) | 2006-09-15 | 2006-10-25 | Lauras As | Process |
| WO2008083465A1 (en) | 2007-01-08 | 2008-07-17 | University Health Network | Pyrimidine derivatives as anticancer agents |
| WO2008086042A2 (en) | 2007-01-10 | 2008-07-17 | Chisari Francis V | Preventing infection by a measles or respiratory syncytial virus |
| NZ598927A (en) | 2007-01-12 | 2013-09-27 | Biocryst Pharm Inc | Antiviral nucleoside analogs |
| WO2008089439A2 (en) | 2007-01-18 | 2008-07-24 | Fred Hutchinson Cancer Research Center | Methods and compositions for enhancing lifespan involving sirtuin-modulating compounds and chalcogenides |
| US7838234B2 (en) | 2007-01-30 | 2010-11-23 | Pharmacyclics, Inc. | Methods for determining cancer resistance to histone deacetylase inhibitors |
| EP2121719A2 (en) | 2007-01-31 | 2009-11-25 | Alios Biopharma, Inc. | 2-5a derivatives and their use as anti-cancer, anti-viral and anti-parasitic agents |
| US8324179B2 (en) | 2007-02-09 | 2012-12-04 | Gilead Sciences, Inc. | Nucleoside analogs for antiviral treatment |
| JP2008214305A (ja) | 2007-03-07 | 2008-09-18 | Kotobuki Seiyaku Kk | 置換アミン誘導体及びこれを有効成分とする医薬組成物 |
| WO2008117046A1 (en) | 2007-03-27 | 2008-10-02 | Astrazeneca Ab | Pyrazolo [4, 3-d] pyrimidines as antibacterial compounds |
| WO2008117047A1 (en) | 2007-03-27 | 2008-10-02 | Astrazeneca Ab | Pyrazolo[3, 4-d]pyrimidine derivatives as antibacterial compounds |
| US7964580B2 (en) * | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| WO2008127613A1 (en) | 2007-04-11 | 2008-10-23 | Scynexis, Inc. | New pharmaceutical compositions |
| EP1980568A1 (de) | 2007-04-13 | 2008-10-15 | Eberhard Karls Universität Tübingen | Ethinylierte Heterodinucleosidphosphatanaloga, Verfahren zu deren Herstellung und deren Verwendung |
| ES2530763T3 (es) | 2007-06-25 | 2015-03-05 | Anadys Pharmaceuticals Inc | Procedimiento continuo de hidrólisis enzimática |
| GB0712494D0 (en) | 2007-06-27 | 2007-08-08 | Isis Innovation | Substrate reduction therapy |
| CN100532388C (zh) * | 2007-07-16 | 2009-08-26 | 郑州大学 | 2’-氟-4’-取代-核苷类似物、其制备方法及应用 |
| EP2019100A1 (en) | 2007-07-19 | 2009-01-28 | Santhera Pharmaceuticals (Schweiz) AG | Substituted heteroarylpiperidine derivatives as melanocortin-4 receptor modulators |
| US20090076062A1 (en) | 2007-09-13 | 2009-03-19 | Juergen Klaus Maibaum | Organic Compounds |
| GB0718575D0 (en) | 2007-09-24 | 2007-10-31 | Angeletti P Ist Richerche Bio | Nucleoside derivatives as inhibitors of viral polymerases |
| DK2227234T3 (da) | 2007-10-15 | 2014-08-11 | Can Fite Biopharma Ltd | Fremgangsmåde til induktion af hepatocytproliferering og anvendelserderaf |
| US20090318380A1 (en) | 2007-11-20 | 2009-12-24 | Pharmasset, Inc. | 2',4'-substituted nucleosides as antiviral agents |
| WO2009086192A1 (en) | 2007-12-21 | 2009-07-09 | Alios Biopharma, Inc. | Biodegradable phosphate protected nucleotide derivatives and their use as cancer, anti viral and anti parasitic agents |
| WO2009086201A1 (en) | 2007-12-21 | 2009-07-09 | Alios Biopharma, Inc. | 2-5a analogs and their use as anti-cancer, anti-viral and anti- paras iti c agents |
| WO2009105712A1 (en) | 2008-02-22 | 2009-08-27 | Irm Llc | Heterocyclic compounds and compositions as c-kit and pdgfr kinase inhibitors |
| WO2009125841A1 (ja) * | 2008-04-10 | 2009-10-15 | 浜理薬品工業株式会社 | 5-メチルウリジンを出発原料とするエチニルチミジン化合物の製造方法 |
| US8513205B2 (en) | 2008-04-11 | 2013-08-20 | Yale University | Potent chimeric NRTI-NNRTI bifunctional inhibitors of HIV-1 reverse transcriptase |
| US8415321B2 (en) | 2008-04-15 | 2013-04-09 | Raymond F. Schinazi | Nucleoside derivatives for treatment of Caliciviridae infections, including Norovirus infections |
| US20090274686A1 (en) * | 2008-05-02 | 2009-11-05 | Yat Sun Or | Nucleoside phosphonate derivatives |
| WO2010036407A2 (en) | 2008-05-15 | 2010-04-01 | Biocryst Pharmaceuticals, Inc. | Antiviral nucleoside analogs |
| US8173621B2 (en) * | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
| DE102008035299A1 (de) | 2008-07-29 | 2010-02-04 | Resprotect Gmbh | Konjugat aus Hsp27 und einem Nukleosid, Verfahren zur Phosphorylierung von Hsp27 und Verwendung zur Herstellung eines Arzneimittels |
| GB0815315D0 (en) | 2008-08-21 | 2008-09-24 | Univ Leiden | Organ protection |
| GB0815968D0 (en) | 2008-09-03 | 2008-10-08 | Angeletti P Ist Richerche Bio | Antiviral agents |
| CN102216316A (zh) | 2008-09-05 | 2011-10-12 | 寿制药株式会社 | 取代胺衍生物及以其为有效成分的药物组合物 |
| US8163707B2 (en) * | 2008-09-15 | 2012-04-24 | Enanta Pharmaceuticals, Inc. | 4′-allene-substituted nucleoside derivatives |
| US8962580B2 (en) | 2008-09-23 | 2015-02-24 | Alnylam Pharmaceuticals, Inc. | Chemical modifications of monomers and oligonucleotides with cycloaddition |
| CN102264374B (zh) | 2008-10-24 | 2015-01-07 | Isis制药公司 | 5′和2′双取代的核苷和由其制备的低聚化合物 |
| US8716263B2 (en) | 2008-12-23 | 2014-05-06 | Gilead Pharmasset Llc | Synthesis of purine nucleosides |
| GB0900914D0 (en) | 2009-01-20 | 2009-03-04 | Angeletti P Ist Richerche Bio | Antiviral agents |
| BRPI1005401A2 (pt) | 2009-02-06 | 2019-04-02 | Rfs Pharma, Llc | pro-farmácos de purina nucleosídeo monofosfato para o tratamento de câncer e infecções virais |
| WO2010088924A1 (en) | 2009-02-06 | 2010-08-12 | Telormedix Sa | Pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof suitable for local administration |
| EP3424939A1 (en) * | 2009-03-02 | 2019-01-09 | Alnylam Pharmaceuticals Inc. | Nucleic acid chemical modifications |
| EP2623104A1 (en) * | 2009-03-20 | 2013-08-07 | Alios Biopharma, Inc. | Substituted nucleoside and nucleotide analogs |
| WO2010108135A1 (en) | 2009-03-20 | 2010-09-23 | Alios Biopharma, Inc. | Protected nucleotide analogs |
| JP2012526831A (ja) | 2009-05-12 | 2012-11-01 | サザン リサーチ インスティテュート | 2’−フルオロアラビノヌクレオシド及びその使用 |
| EP2264169A1 (en) | 2009-06-15 | 2010-12-22 | Qiagen GmbH | Modified siNA |
| US20100331397A1 (en) | 2009-06-24 | 2010-12-30 | Alios Biopharma, Inc. | 2-5a analogs and their methods of use |
| WO2011005860A2 (en) | 2009-07-07 | 2011-01-13 | Alnylam Pharmaceuticals, Inc. | 5' phosphate mimics |
| TW201111378A (en) | 2009-09-11 | 2011-04-01 | Bayer Schering Pharma Ag | Substituted (heteroarylmethyl) thiohydantoins |
| WO2011057204A2 (en) | 2009-11-06 | 2011-05-12 | The Johns Hopkins University | Lrrk2-mediated neuronal toxicity |
| US9198972B2 (en) | 2010-01-28 | 2015-12-01 | Alnylam Pharmaceuticals, Inc. | Monomers and oligonucleotides comprising cycloaddition adduct(s) |
| US20130109645A1 (en) | 2010-03-31 | 2013-05-02 | The united States of America,as represented by Secretary,Dept.,of Health and Human Services | Adenosine receptor agonists for the treatment and prevention of vascular or joint capsule calcification disorders |
| WO2011133871A2 (en) | 2010-04-22 | 2011-10-27 | Alnylam Pharmaceuticals, Inc. | 5'-end derivatives |
| KR101701510B1 (ko) | 2010-07-09 | 2017-02-01 | 엘지이노텍 주식회사 | 발광소자 |
| EP2805960A1 (en) | 2010-07-19 | 2014-11-26 | Gilead Sciences, Inc. | Methods for the preparation of diasteromerically pure phosphoramidate prodrugs |
| US20120027752A1 (en) | 2010-07-22 | 2012-02-02 | Gilead Sciences, Inc. | Methods and compounds for treating paramyxoviridae virus infections |
| JP5640552B2 (ja) | 2010-08-23 | 2014-12-17 | セイコーエプソン株式会社 | 制御装置、表示装置及び表示装置の制御方法 |
| US20120070411A1 (en) | 2010-09-22 | 2012-03-22 | Alios Biopharma, Inc. | Substituted nucleotide analogs |
| CA2812962C (en) | 2010-09-22 | 2020-03-31 | Alios Biopharma, Inc. | Azido nucleosides and nucleotide analogs |
| US8871737B2 (en) | 2010-09-22 | 2014-10-28 | Alios Biopharma, Inc. | Substituted nucleotide analogs |
| WO2012041965A1 (en) | 2010-09-29 | 2012-04-05 | Universidad Nacional De Quilmes | Process for producing dialkylphosphotriesters of nucleosides by enzymatic transesterification and deprotection thereof for producing nucleoside monophosphates |
| BR112013013659B8 (pt) | 2010-12-03 | 2024-02-27 | Epizyme Inc | Compostos moduladores de enzimas epigenéticas, composição farmacêutica compreendendo ditos compostos e usos da dita composição farmacêutica para tratar câncer, câncer hematológico ou leucemia |
| EP2655392B1 (en) | 2010-12-22 | 2018-04-18 | Alios Biopharma, Inc. | Cyclic nucleotide analogs |
| CN103403014B (zh) | 2011-01-03 | 2016-07-06 | 河南美泰宝生物制药有限公司 | O-(经取代的苯甲基)氨基磷酸酯化合物及其治疗用途 |
| US9334300B2 (en) | 2011-08-01 | 2016-05-10 | Mbc Pharma, Inc. | Vitamin B6 derivatives of nucleotides, acyclonucleotides and acyclonucleoside phosphonates |
| CN103102345B (zh) | 2011-11-14 | 2015-06-03 | 广东东阳光药业有限公司 | 氨基喹唑啉类衍生物及其盐和使用方法 |
| WO2013128465A1 (en) | 2011-12-22 | 2013-09-06 | Connexios Life Sciences Pvt. Ltd. | Cyclic amide derivatives as inhibitors of 11 - beta - hydroxysteroid dehydrogenase and uses thereof |
| DK2794600T3 (en) | 2011-12-22 | 2018-03-12 | Novartis Ag | -2,3-Dihydro-benzo [1,4] oxazine derivatives and related compounds such as phosphoinositide 3-kinase (PI3K) inhibitors for the treatment of rheumatoid arthritis |
| MX358696B (es) | 2011-12-22 | 2018-08-31 | Connexios Life Sciences Pvt Ltd | Derivados de aza adamantano y lo usos de los mismos. |
| MX356509B (es) | 2011-12-22 | 2018-05-30 | Alios Biopharma Inc | Nucleósidos sustituidos, nucleótidos y análogos de los mismos. |
| AR089284A1 (es) | 2011-12-22 | 2014-08-13 | Galapagos Nv | Dihidropirimidinoisoquinolinonas y composiciones farmaceuticas de las mismas para el tratamiento de trastornos inflamatorios |
| US8980865B2 (en) | 2011-12-22 | 2015-03-17 | Alios Biopharma, Inc. | Substituted nucleotide analogs |
| KR102068856B1 (ko) | 2012-03-13 | 2020-01-21 | 길리애드 사이언시즈, 인코포레이티드 | 항바이러스 치료를 위한 2'-치환된 카바-뉴클레오시드 유사체 |
| WO2013138210A1 (en) | 2012-03-14 | 2013-09-19 | Ning Xi | Substituted cyclic compounds and methods of use |
| USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| EP2828278A4 (en) | 2012-03-21 | 2015-12-09 | Alios Biopharma Inc | PROCESSES FOR PREPARING SUBSTITUTED NUCLEOTIDE ANALOGS |
| CN104321333A (zh) | 2012-03-21 | 2015-01-28 | 沃泰克斯药物股份有限公司 | 硫代氨基磷酸酯核苷酸前药的固体形式 |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| SG11201405351RA (en) | 2012-03-21 | 2014-10-30 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| WO2013142159A1 (en) | 2012-03-21 | 2013-09-26 | Alios Biopharma, Inc. | Pharmaceutical combinations comprising a thionucleotide analog |
| EP2827876A4 (en) | 2012-03-22 | 2015-10-28 | Alios Biopharma Inc | PHARMACEUTICAL COMBINATIONS WITH A THIONUCLEOTIDE ANALOG |
| WO2013151975A1 (en) | 2012-04-02 | 2013-10-10 | Northeastern University | Compositions and methods for the inhibition of methyltransferases |
| BR112014029115A8 (pt) | 2012-05-22 | 2018-04-03 | Idenix Pharmaceuticals Inc | Composto, composição farmacêutica, e, uso de um composto ou composição |
| EP2870169A1 (en) | 2012-07-03 | 2015-05-13 | Bristol-Myers Squibb Company | Process for preparing diastereomerically enriched phosphoramidate derivatives of nucleoside compounds for treatment of viral infections |
| WO2014022639A1 (en) | 2012-08-01 | 2014-02-06 | Vertex Pharmaceuticals Incorporated | Solid forms of (4-isopropoxy-3-methoxyphenyl)(2'-methyl-6'-(trifluoromethyl)-3',4'-dihydro-2'h-spiro[piperidine-4,1'-pyrrolo[1,2-a]pyrazine]-1-yl)methanone |
| US20150284422A1 (en) | 2012-08-10 | 2015-10-08 | Epizyme, Inc. | Inhibitors of protein methyltransferase dot1l and methods of use thereof |
| JP6533896B2 (ja) | 2012-09-04 | 2019-06-26 | 株式会社ダナフォーム | 化合物、核酸、標識物質および検出方法 |
| PT2900657T (pt) | 2012-09-26 | 2020-05-07 | Hoffmann La Roche | Compostos cíclicos de éter-pirazol-4-il-heterociclil-carboxamida e métodos de utilização |
| MX362855B (es) | 2012-09-26 | 2019-02-20 | Merck Patent Gmbh | Derivados de quinazolinona como inhidores poli (adp-ribosa) polimerasa (parp). |
| BR112015009636A8 (pt) | 2012-10-29 | 2018-04-17 | Cocrystal Pharma Inc | composto, métodos para o tratamento de um hospedeiro infectado, métodos para a prevenção de uma infecção, métodos para a redução da atividade biológica de uma infecção e uso de um composto |
| GB201220843D0 (en) | 2012-11-20 | 2013-01-02 | Univ College Cork Nat Univ Ie | Compound |
| PE20151433A1 (es) | 2012-12-21 | 2015-10-16 | Alios Biopharma Inc | Nucleosidos sustituidos, nucleotidos y analogos de los mismos |
| US9598457B2 (en) | 2012-12-21 | 2017-03-21 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| US20150065439A1 (en) | 2013-02-28 | 2015-03-05 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions |
| US20140309413A1 (en) | 2013-03-11 | 2014-10-16 | Vertex Pharmaceuticals Incorporated | Methods of stereoselective synthesis of substituted nucleoside analogs |
| AR099632A1 (es) | 2013-04-05 | 2016-08-10 | Alios Biopharma Inc | Tratamiento de una infección viral de hepatitis c, que usa una combinación de compuestos |
| CA2913206C (en) | 2013-06-26 | 2022-08-02 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| GEP201706793B (en) | 2013-06-26 | 2017-12-11 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| WO2015054465A1 (en) | 2013-10-11 | 2015-04-16 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| WO2015200219A1 (en) | 2014-06-24 | 2015-12-30 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| EP3160475B1 (en) | 2014-06-24 | 2024-01-03 | Janssen Pharmaceuticals, Inc. | Substituted nucleosides and nucleotides to treat filoviridae infections |
| NZ727392A (en) | 2014-06-24 | 2018-04-27 | Alios Biopharma Inc | Methods of preparing substituted nucleotide analogs |
| BR112017001162A2 (pt) | 2014-07-22 | 2017-11-14 | Alios Biopharma Inc | métodos para tratar paramixovírus |
| EP3177299A4 (en) | 2014-08-05 | 2018-04-04 | Alios Biopharma, Inc. | Combination therapy for treating a paramyxovirus |
| TWI673283B (zh) | 2014-08-21 | 2019-10-01 | 美商基利科學股份有限公司 | 2’-氯胺基嘧啶酮及嘧啶二酮核苷類 |
| US9981175B2 (en) | 2014-09-12 | 2018-05-29 | Dan DeLaRosa | Taekwondo bag |
| WO2016069489A1 (en) | 2014-10-28 | 2016-05-06 | Alios Biopharma, Inc. | Methods of preparing substituted nucleoside analogs |
| MA41441A (fr) | 2014-12-19 | 2017-12-12 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
| MA41213A (fr) | 2014-12-19 | 2017-10-24 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
| TW201811339A (zh) | 2016-08-12 | 2018-04-01 | 美商艾洛斯生物製藥公司 | 經取代之核苷、核苷酸及其類似物 |
| WO2018081449A1 (en) | 2016-10-27 | 2018-05-03 | Alios Biopharma, Inc. | Methods for treating respiratory syncytial virus infection |
-
2012
- 2012-12-20 MX MX2014007480A patent/MX356509B/es active IP Right Grant
- 2012-12-20 SG SG10201913554YA patent/SG10201913554YA/en unknown
- 2012-12-20 US US13/721,988 patent/US9073960B2/en not_active Expired - Fee Related
- 2012-12-20 BR BR112014014740-0A patent/BR112014014740B1/pt not_active IP Right Cessation
- 2012-12-20 JP JP2014548912A patent/JP6385825B2/ja not_active Expired - Fee Related
- 2012-12-20 GE GEAP201213529A patent/GEP20166496B/en unknown
- 2012-12-20 RS RS20181560A patent/RS58099B1/sr unknown
- 2012-12-20 CA CA3107640A patent/CA3107640A1/en not_active Abandoned
- 2012-12-20 HR HRP20182096TT patent/HRP20182096T1/hr unknown
- 2012-12-20 AP AP2014007796A patent/AP2014007796A0/xx unknown
- 2012-12-20 ES ES12860391T patent/ES2702060T3/es active Active
- 2012-12-20 CA CA2860289A patent/CA2860289C/en active Active
- 2012-12-20 UA UAA201408335A patent/UA117095C2/uk unknown
- 2012-12-20 EP EP18196511.2A patent/EP3466959A1/en not_active Ceased
- 2012-12-20 EA EA201491040A patent/EA035493B1/ru not_active IP Right Cessation
- 2012-12-20 SI SI201231479T patent/SI2794627T1/sl unknown
- 2012-12-20 EP EP12860391.7A patent/EP2794627B1/en active Active
- 2012-12-20 DK DK12860391.7T patent/DK2794627T3/en active
- 2012-12-20 CN CN201710692170.4A patent/CN107459544B/zh not_active Expired - Fee Related
- 2012-12-20 UY UY0001034536A patent/UY34536A/es not_active Application Discontinuation
- 2012-12-20 PT PT12860391T patent/PT2794627T/pt unknown
- 2012-12-20 SM SM20180662T patent/SMT201800662T1/it unknown
- 2012-12-20 CN CN201280069475.5A patent/CN104114568B/zh not_active Expired - Fee Related
- 2012-12-20 AU AU2012358803A patent/AU2012358803C1/en not_active Ceased
- 2012-12-20 HU HUE12860391A patent/HUE041509T2/hu unknown
- 2012-12-20 KR KR1020147019834A patent/KR102072041B1/ko not_active Expired - Fee Related
- 2012-12-20 PL PL12860391T patent/PL2794627T3/pl unknown
- 2012-12-20 LT LTEP12860391.7T patent/LT2794627T/lt unknown
- 2012-12-20 SG SG10201610936RA patent/SG10201610936RA/en unknown
- 2012-12-20 WO PCT/US2012/071063 patent/WO2013096679A1/en not_active Ceased
- 2012-12-20 SG SG11201402826YA patent/SG11201402826YA/en unknown
- 2012-12-20 HK HK15103629.6A patent/HK1203204A1/xx unknown
- 2012-12-21 TW TW101149140A patent/TWI659963B/zh not_active IP Right Cessation
- 2012-12-21 AR ARP120104913A patent/AR089408A1/es active IP Right Grant
-
2014
- 2014-06-16 IL IL233152A patent/IL233152B/en active IP Right Grant
- 2014-06-18 ZA ZA2014/04486A patent/ZA201404486B/en unknown
- 2014-06-19 MX MX2018006658A patent/MX2018006658A/es unknown
- 2014-06-19 CL CL2014001641A patent/CL2014001641A1/es unknown
- 2014-06-20 PH PH12014501436A patent/PH12014501436A1/en unknown
- 2014-06-25 CO CO14137284A patent/CO6990737A2/es unknown
- 2014-07-22 EC ECIEPI201410277A patent/ECSP14010277A/es unknown
-
2015
- 2015-07-02 US US14/790,645 patent/US10464965B2/en not_active Expired - Fee Related
- 2015-09-30 PH PH12015502273A patent/PH12015502273A1/en unknown
-
2018
- 2018-05-15 AU AU2018203423A patent/AU2018203423B2/en not_active Ceased
- 2018-06-08 HK HK18107469.7A patent/HK1248239A1/zh unknown
- 2018-08-08 JP JP2018149017A patent/JP6718487B2/ja not_active Expired - Fee Related
- 2018-12-13 CY CY20181101341T patent/CY1121416T1/el unknown
-
2019
- 2019-07-31 US US16/528,414 patent/US11021509B2/en not_active Expired - Fee Related
-
2020
- 2020-02-27 IL IL272953A patent/IL272953B/en unknown
-
2021
- 2021-02-17 US US17/178,151 patent/US20210179656A1/en not_active Abandoned
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140138977A (ko) * | 2012-03-21 | 2014-12-04 | 앨리오스 바이오파마 인크. | 치환된 뉴클레오사이드, 뉴클레오타이드 및 그의 유사체 |
| KR102172040B1 (ko) * | 2012-03-21 | 2020-10-30 | 얀센 바이오파마, 인코퍼레이트. | 치환된 뉴클레오사이드, 뉴클레오타이드 및 그의 유사체 |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR102072041B1 (ko) | 치환된 뉴클레오사이드, 뉴클레오타이드 및 그의 유사체 | |
| KR102172040B1 (ko) | 치환된 뉴클레오사이드, 뉴클레오타이드 및 그의 유사체 | |
| US10485815B2 (en) | Substituted nucleosides, nucleotides and analogs thereof | |
| USRE48171E1 (en) | Substituted nucleosides, nucleotides and analogs thereof | |
| HK1203076B (en) | Substituted nucleosides, nucleotides and analogs thereof | |
| HK1203143B (en) | Substituted nucleosides, nucleotides and analogs thereof | |
| NZ627179B2 (en) | Substituted nucleosides, nucleotides and analogs thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
|
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| R17-X000 | Change to representative recorded |
St.27 status event code: A-3-3-R10-R17-oth-X000 |
|
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| PA0201 | Request for examination |
St.27 status event code: A-1-2-D10-D11-exm-PA0201 |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
St.27 status event code: A-1-2-D10-D21-exm-PE0902 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
St.27 status event code: A-1-2-D10-D22-exm-PE0701 |
|
| PR0701 | Registration of establishment |
St.27 status event code: A-2-4-F10-F11-exm-PR0701 |
|
| PR1002 | Payment of registration fee |
St.27 status event code: A-2-2-U10-U12-oth-PR1002 Fee payment year number: 1 |
|
| PG1601 | Publication of registration |
St.27 status event code: A-4-4-Q10-Q13-nap-PG1601 |
|
| PN2301 | Change of applicant |
St.27 status event code: A-5-5-R10-R13-asn-PN2301 St.27 status event code: A-5-5-R10-R11-asn-PN2301 |
|
| PC1903 | Unpaid annual fee |
St.27 status event code: A-4-4-U10-U13-oth-PC1903 Not in force date: 20230124 Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE |
|
| PC1903 | Unpaid annual fee |
St.27 status event code: N-4-6-H10-H13-oth-PC1903 Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE Not in force date: 20230124 |