ES2530763T3 - Procedimiento continuo de hidrólisis enzimática - Google Patents

Procedimiento continuo de hidrólisis enzimática Download PDF

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Publication number
ES2530763T3
ES2530763T3 ES07110957T ES07110957T ES2530763T3 ES 2530763 T3 ES2530763 T3 ES 2530763T3 ES 07110957 T ES07110957 T ES 07110957T ES 07110957 T ES07110957 T ES 07110957T ES 2530763 T3 ES2530763 T3 ES 2530763T3
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ES
Spain
Prior art keywords
enzymatic hydrolysis
hydrolysis procedure
substrate
continuous enzymatic
buffered solution
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ES07110957T
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English (en)
Inventor
Fabrice Gallou
Pascal Beney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anadys Pharmaceuticals Inc
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Anadys Pharmaceuticals Inc
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Publication date
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Publication of ES2530763T3 publication Critical patent/ES2530763T3/es
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Procedimiento para la hidrólisis enzimática regioselectiva de un sustrato que comprende hacer pasar una disolución tamponada a través de una enzima inmovilizada en un procedimiento continuo, en el que el sustrato es**Fórmula** la enzima es lipasa de Candida Antarctica Novozym 435; la disolución tamponada tiene un pH de 5,5 a 7,5; y la lipasa de Candida Antarctica hidroliza de manera regioselectiva el éster en la posición 5' del sustrato.
ES07110957T 2007-06-25 2007-06-25 Procedimiento continuo de hidrólisis enzimática Active ES2530763T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07110957.3A EP2014771B1 (en) 2007-06-25 2007-06-25 Continuous enzymatic hydrolysis process

Publications (1)

Publication Number Publication Date
ES2530763T3 true ES2530763T3 (es) 2015-03-05

Family

ID=39111421

Family Applications (1)

Application Number Title Priority Date Filing Date
ES07110957T Active ES2530763T3 (es) 2007-06-25 2007-06-25 Procedimiento continuo de hidrólisis enzimática

Country Status (14)

Country Link
US (2) US20110091943A1 (es)
EP (1) EP2014771B1 (es)
JP (1) JP5559046B2 (es)
CN (1) CN101720333B (es)
AU (1) AU2008268384B2 (es)
CA (1) CA2692437C (es)
DK (1) DK2014771T3 (es)
ES (1) ES2530763T3 (es)
HK (1) HK1126820A1 (es)
MX (1) MX2009014280A (es)
PL (1) PL2014771T3 (es)
SI (1) SI2014771T1 (es)
TW (1) TWI438280B (es)
WO (1) WO2009003042A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE041509T2 (hu) 2011-12-22 2019-05-28 Janssen Biopharma Inc Szubsztituált nukleozidok, nukleotidok és ezek analógjai
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
SG11201407336PA (en) 2012-05-25 2015-03-30 Janssen Sciences Ireland Uc Uracyl spirooxetane nucleosides
CA2894542C (en) 2012-12-21 2023-10-31 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9862743B2 (en) 2013-10-11 2018-01-09 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
KR102363946B1 (ko) 2015-03-06 2022-02-17 아테아 파마슈티컬즈, 인크. HCV 치료를 위한 β-D-2'-데옥시-2'-α-플루오로-2'-β-C-치환된-2-변형된-N6-치환된 퓨린 뉴클레오티드
KR20190043602A (ko) 2016-09-07 2019-04-26 아테아 파마슈티컬즈, 인크. Rna 바이러스 치료를 위한 2'-치환된-n6-치환된 퓨린 뉴클레오티드
GEP20237457B (en) 2017-02-01 2023-01-10 Atea Pharmaceuticals Inc Nucleotide hemi-sulfate salt for treatment of hepatitis c virus
TW202012001A (zh) 2018-04-10 2020-04-01 美商亞堤製藥公司 C型肝炎病毒(hcv)感染硬化之患者的治療
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3836432A (en) * 1969-09-25 1974-09-17 Hokkaido Sugar Co Continuous process for the hydrolysis of raffinose
FR2648147B1 (fr) * 1989-06-13 1991-08-16 Gattefosse Ets Sa Procede pour la preparation de beta-monoglycerides et produits obtenus
US5538891A (en) * 1991-09-02 1996-07-23 Boehringer Mannheim Gmbh Process for enzymatic production of isomerically pure isosorbide-2 and 5-monoesters and their conversion to isosorbide-2 and -5 nitrate
US5686426A (en) * 1994-11-17 1997-11-11 Bristol-Myers Squibb Company Dicarboxymethylated glycolipid derivatives as cell adhesion inhibitors
US6833471B2 (en) * 2002-09-09 2004-12-21 Biocatalytics, Inc. Methods for producing hydroxy amino acids and derivatives thereof
CA2566541C (en) * 2004-06-07 2012-10-09 Anadys Pharmaceuticals, Inc. 3-.beta.-d-ribofuranosylthiazolo[4,5-d]pyrimidine nucleosides and uses thereof
DE102005002700A1 (de) * 2005-01-19 2006-07-27 Cognis Deutschland Gmbh & Co. Kg Zusammensetzungen verwendbar als Biotreibstoff

Also Published As

Publication number Publication date
AU2008268384B2 (en) 2013-09-26
PL2014771T3 (pl) 2015-05-29
DK2014771T3 (en) 2015-03-09
SI2014771T1 (sl) 2015-04-30
US20110091943A1 (en) 2011-04-21
CN101720333A (zh) 2010-06-02
JP5559046B2 (ja) 2014-07-23
TWI438280B (zh) 2014-05-21
AU2008268384A1 (en) 2008-12-31
EP2014771A1 (en) 2009-01-14
US20130137143A1 (en) 2013-05-30
JP2011500001A (ja) 2011-01-06
CN101720333B (zh) 2012-08-29
MX2009014280A (es) 2010-06-23
CA2692437C (en) 2016-04-19
WO2009003042A1 (en) 2008-12-31
TW200911997A (en) 2009-03-16
EP2014771B1 (en) 2014-12-03
HK1126820A1 (en) 2009-09-11
CA2692437A1 (en) 2008-12-31

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