AR073113A1 - Produccion de metionina sin n- acil -metionina - Google Patents
Produccion de metionina sin n- acil -metioninaInfo
- Publication number
- AR073113A1 AR073113A1 ARP090103230A ARP090103230A AR073113A1 AR 073113 A1 AR073113 A1 AR 073113A1 AR P090103230 A ARP090103230 A AR P090103230A AR P090103230 A ARP090103230 A AR P090103230A AR 073113 A1 AR073113 A1 AR 073113A1
- Authority
- AR
- Argentina
- Prior art keywords
- methionine
- expression
- production
- microorganism
- source
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/12—Methionine; Cysteine; Cystine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/66—Aspergillus
- C12R2001/69—Aspergillus oryzae
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Reivindicacion 1: Un procedimiento para la produccion de metionina, o sus precursores en un proceso fermentativo que comprende las siguientes etapas: i) cultivo de un microorganismo modificado en un medio de cultivo apropiado que comprende una fuente de carbono, una fuente de azufre y una fuente de nitrogeno y ii) recuperacion de metionina y/o sus derivados a partir del medio de cultivo, en el que en comparacion con un microorganismo o un procedimiento no modificado, la acumulacion del subproducto N-acil-metionina es reducida. Reivindicacion 3: Procedimiento de la reivindicacion 1 en el que dicha reduccion de la acumulacion de N-acil-metionina se logra mediante una de las siguientes modificaciones: i) Atenuacion de la expresion de al menos una enzima metionina transacilasa, y/o, ii) Expresion o potenciacion de la expresion de al menos una aminoacilasa específica de la metionina, y/o, iii) Cambio de las condiciones de cultivo. Reivindicacion 19: Un microorganismo que comprende las modificaciones reivindicadas en la reivindicacion 3.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2008/061005 WO2010020290A1 (en) | 2008-08-22 | 2008-08-22 | Producing methionine without n-acetyl methionine |
| US12/370,422 US8748136B2 (en) | 2008-08-22 | 2009-02-12 | Producing methionine without N-acyl-methionine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR073113A1 true AR073113A1 (es) | 2010-10-13 |
Family
ID=40683227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090103230A AR073113A1 (es) | 2008-08-22 | 2009-08-21 | Produccion de metionina sin n- acil -metionina |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8748136B2 (es) |
| EP (1) | EP2326724B1 (es) |
| JP (1) | JP5805533B2 (es) |
| KR (1) | KR101660060B1 (es) |
| CN (2) | CN104293845A (es) |
| AR (1) | AR073113A1 (es) |
| BR (1) | BRPI0917192A2 (es) |
| ES (1) | ES2739466T3 (es) |
| MX (1) | MX2011001962A (es) |
| MY (1) | MY174404A (es) |
| PL (1) | PL2326724T3 (es) |
| RU (1) | RU2011108705A (es) |
| WO (2) | WO2010020290A1 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2012DN06442A (es) | 2009-12-30 | 2015-10-09 | Metabolic Explorer Sa | |
| AR083468A1 (es) * | 2010-10-25 | 2013-02-27 | Metabolic Explorer Sa | Aumento de la disponibilidad de nadph para la produccion de metionina |
| EP2468383A1 (de) * | 2010-12-22 | 2012-06-27 | Evonik Degussa GmbH | Verfahren zur thermischen Nachverbrennung von Abgasen aus der Acrolein- und aus der Blausäureherstellung |
| CN103429748B (zh) | 2010-12-30 | 2016-01-06 | 代谢探索者公司 | 甲硫氨酸羟基类似物(mha)的发酵产生 |
| WO2012090021A1 (en) | 2010-12-30 | 2012-07-05 | Metabolic Explorer | Recombinant microorganism for the fermentative production of methionine |
| EP2479279A1 (de) | 2011-01-20 | 2012-07-25 | Evonik Degussa GmbH | Verfahren zur fermentativen Herstellung schwefelhaltiger Aminosäuren |
| US9234223B2 (en) | 2011-04-01 | 2016-01-12 | Ajinomoto Co., Inc. | Method for producing L-cysteine |
| CN104160024A (zh) | 2011-04-01 | 2014-11-19 | 味之素株式会社 | 用于生产l-半胱氨酸的方法 |
| AR086790A1 (es) * | 2011-06-29 | 2014-01-22 | Metabolic Explorer Sa | Un microorganismo para la produccion de metionina con importacion de glucosa mejorada |
| US9506093B2 (en) | 2012-06-18 | 2016-11-29 | Metabolic Explorer | Recombinant microorganism for the fermentative production of methionine |
| ES2689754T3 (es) | 2012-08-20 | 2018-11-15 | Evonik Degussa Gmbh | Procedimiento para la preparación fermentativa de L-aminoácidos utilizando cepas mejoradas de la familia Enterobacteriaceae |
| EP2762571A1 (de) | 2013-01-30 | 2014-08-06 | Evonik Industries AG | Mikroorganismus und Verfahren zur fermentativen Herstellung von Aminosäuren |
| BR112016004367B1 (pt) | 2013-08-30 | 2022-06-14 | Evonik Operations Gmbh | Microrganismo recombinante e método para a produção fermentativa de metionina e/ou seus derivados |
| RU2723714C2 (ru) | 2014-09-01 | 2020-06-17 | Эвоник Оперейшнс Гмбх | Способ и микроорганизм для ферментативного продуцирования метионина с улучшенным выходом метионина |
| EP3331998B1 (en) | 2015-08-07 | 2020-06-24 | Evonik Operations GmbH | Protein thiocarboxylate-dependent l-methionine production by fermentation |
| FR3041659B1 (fr) | 2015-09-30 | 2017-10-20 | Arkema France | Procede de production de l-methionine |
| FR3041658B1 (fr) | 2015-09-30 | 2017-10-20 | Arkema France | Procede de production de l-methionine |
| PL3380627T3 (pl) | 2015-11-27 | 2020-01-31 | Evonik Degussa Gmbh | Sposób wytwarzania L-metioniny |
| EP3296404A1 (en) * | 2016-09-15 | 2018-03-21 | Evonik Degussa GmbH | Modified microorganism for production of methionine |
| KR102472558B1 (ko) * | 2019-06-28 | 2022-12-01 | 씨제이제일제당 주식회사 | 황 함유 아미노산 또는 그 유도체 제조방법 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001281489A1 (en) | 2000-03-10 | 2001-10-03 | Trustees Of Tufts College | NIMR compositions and their methods of use |
| JP4682454B2 (ja) * | 2000-06-28 | 2011-05-11 | 味の素株式会社 | 新規変異型ｎ−アセチルグルタミン酸合成酵素及びｌ−アルギニンの製造法 |
| DE10144493A1 (de) * | 2001-09-11 | 2003-07-03 | Degussa | Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coyneformer Bakterien |
| DE102004013503A1 (de) * | 2004-03-18 | 2005-10-06 | Degussa Ag | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien |
| DE102004055414A1 (de) * | 2004-11-17 | 2006-05-24 | Degussa Ag | Allele des metK-Gens aus coryneformen Bakterien |
| CA2615315C (en) * | 2005-07-18 | 2015-10-06 | Basf Aktiengesellschaft | Use of dimethyl disulfide for methionine production in microorganisms |
| EP2543726B1 (en) * | 2005-08-20 | 2018-10-03 | Scarab Genomics, LLC | Reduced genome E. coli |
| JP4913818B2 (ja) * | 2005-10-31 | 2012-04-11 | エボニック デグサ ゲーエムベーハー | Ｌ−メチオニン調製のための微生物および方法 |
| CN101351558B (zh) * | 2006-01-04 | 2013-08-14 | 代谢探索者公司 | 使用硫酸盐通透酶表达增强的微生物制备甲硫氨酸及其前体高丝氨酸或琥珀酰高丝氨酸的方法 |
| WO2009043372A1 (en) * | 2007-10-02 | 2009-04-09 | Metabolic Explorer | Increasing methionine yield |
| WO2010020289A1 (en) * | 2008-08-22 | 2010-02-25 | Metabolic Explorer | Production of n-acetylated sulphur-containing amino acids with microorganisms having enhanced n-acetyltransferase enzymatic activity |
-
2008
- 2008-08-22 WO PCT/EP2008/061005 patent/WO2010020290A1/en active Application Filing
-
2009
- 2009-02-12 US US12/370,422 patent/US8748136B2/en active Active
- 2009-08-21 BR BRPI0917192-4A2A patent/BRPI0917192A2/pt active IP Right Grant
- 2009-08-21 CN CN201410478758.6A patent/CN104293845A/zh active Pending
- 2009-08-21 KR KR1020117006419A patent/KR101660060B1/ko active IP Right Grant
- 2009-08-21 ES ES09782063T patent/ES2739466T3/es active Active
- 2009-08-21 AR ARP090103230A patent/AR073113A1/es unknown
- 2009-08-21 MX MX2011001962A patent/MX2011001962A/es active IP Right Grant
- 2009-08-21 CN CN2009801419503A patent/CN102203270A/zh active Pending
- 2009-08-21 WO PCT/EP2009/060811 patent/WO2010020681A1/en active Application Filing
- 2009-08-21 PL PL09782063T patent/PL2326724T3/pl unknown
- 2009-08-21 JP JP2011523426A patent/JP5805533B2/ja not_active Expired - Fee Related
- 2009-08-21 RU RU2011108705/10A patent/RU2011108705A/ru not_active Application Discontinuation
- 2009-08-21 EP EP09782063.3A patent/EP2326724B1/en not_active Not-in-force
- 2009-08-21 MY MYPI2011000771A patent/MY174404A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US8748136B2 (en) | 2014-06-10 |
| KR20110046542A (ko) | 2011-05-04 |
| RU2011108705A (ru) | 2012-09-27 |
| BRPI0917192A2 (pt) | 2015-02-18 |
| WO2010020681A1 (en) | 2010-02-25 |
| EP2326724A1 (en) | 2011-06-01 |
| WO2010020290A1 (en) | 2010-02-25 |
| JP5805533B2 (ja) | 2015-11-04 |
| MX2011001962A (es) | 2011-03-21 |
| PL2326724T3 (pl) | 2019-11-29 |
| US20100047879A1 (en) | 2010-02-25 |
| CN102203270A (zh) | 2011-09-28 |
| JP2012500622A (ja) | 2012-01-12 |
| EP2326724B1 (en) | 2019-05-22 |
| ES2739466T3 (es) | 2020-01-31 |
| KR101660060B1 (ko) | 2016-09-26 |
| MY174404A (en) | 2020-04-16 |
| CN104293845A (zh) | 2015-01-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR073113A1 (es) | Produccion de metionina sin n- acil -metionina | |
| AR058914A1 (es) | Metodo para la producion de metionina mediante el cultivo de un microorganismo modificado para potenciar la produccion de cisteina | |
| AR068722A1 (es) | Metodo para la produccion de metionina, sus derivados o precursores a partir de un proceso fermentativo | |
| PE20051135A1 (es) | Microorganismo productor del acido l-glutamico y metodo para producir acido l-glutamico | |
| AR079187A1 (es) | Proceso de fermentacion para la produccion de acido glicolico | |
| AR079459A1 (es) | Uso de promotores inducibles en la produccion de metionina | |
| BRPI0506369A (pt) | microorganismos, e, métodos para produzir um l-aminoácido | |
| MX347843B (es) | Un microorganismo para la producción de metionina con importación de glucosa mejorada. | |
| DE602004032375D1 (de) | Verfahren zur l-aminosäureherstellung mittels fermentation | |
| AR066195A1 (es) | Microorganismo modificado metabolicamente util para la produccion de 1,2- propanodiol | |
| EA201200561A1 (ru) | Способ ферментативного гидролиза лигноцеллюлозного материала и ферментации сахаров | |
| BR112013009552A2 (pt) | produção de butanol a partir de monóxido de carbono por um micro-organismo recombinante | |
| DK2222865T3 (da) | Fremgangsmåde til fremstilling af alkohol i sammenhæng med bioraffinaderi | |
| BR112012019838A2 (pt) | metodo para a producao de um produto de fermentacao a partir de uma materia-prima lignocelulosica | |
| ATE370224T1 (de) | Verfahren zur herstellung von l-cystein unter verwendung eines zur gattung escherichia gehörenden bakteriums | |
| BR112016023823A2 (pt) | método para produção de um produto de fermentação | |
| WO2011115439A3 (ko) | 5'-크산틸산 및 5'-구아닐산 생산능이 향상된 미생물 및 이를 이용한 5'-크산틸산 또는 5'-구아닐산의 생산방법 | |
| EA200970226A1 (ru) | Термофильные микроорганизмы для производства этанола | |
| AR079764A1 (es) | Aumento de la produccion de metionina mediante la sobreexpresion de succinato deshidrogenasa | |
| CO6390008A2 (es) | Proceso para la producción de una preparación enzimática para hidrólisis de celulosa a partir de residuos lignocelulósicos y aplicación de este en la producción de etanol | |
| DE502008003233D1 (de) | Clostridium sartagoformum zur Erzeugung von Biogas | |
| MX342758B (es) | Microorganismo y proceso para la produccion fermentativa de compuesto organo quimico. | |
| MY194236A (en) | Yeast strain having improved capability for fermenting xylose in the presence of acetic acid | |
| AR084596A1 (es) | Produccion fermentativa de analogo de hidroximetionina (mha) | |
| BR112019023845A2 (pt) | processo de produção de um composto orgânico, micro-organismo geneticamente modificado e uso de um micro-organismo geneticamente modificado |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |