AR058914A1 - Metodo para la producion de metionina mediante el cultivo de un microorganismo modificado para potenciar la produccion de cisteina - Google Patents
Metodo para la producion de metionina mediante el cultivo de un microorganismo modificado para potenciar la produccion de cisteinaInfo
- Publication number
- AR058914A1 AR058914A1 ARP070100036A ARP070100036A AR058914A1 AR 058914 A1 AR058914 A1 AR 058914A1 AR P070100036 A ARP070100036 A AR P070100036A AR P070100036 A ARP070100036 A AR P070100036A AR 058914 A1 AR058914 A1 AR 058914A1
- Authority
- AR
- Argentina
- Prior art keywords
- production
- metionin
- cysteine
- crop
- power
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/12—Methionine; Cysteine; Cystine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Un proceso para la produccion de metionina o sus derivados mediante el cultivo de un microorganismo en un medio de cultivo apropiado que comprende una fuente de carbono y una fuente de azufre. El microorganismo reivindicado se modifica de manera tal que la produccion de cisterna y/o unidades C1 se potencie y/o se incremente u optimice el potencial de transferencia de las unidades C1 de la homocisteína. También se reivindica el aislamiento de la metionina o sus derivados del medio de fermentacion. Reivindicacion 4: El método de acuerdo con la reivindicacion 2, en el cual se incrementa por lo menos la expresion de cysE. Reivindicacion 5: El método de acuerdo con la reivindicacion 2, en el cual se incrementa por lo menos la expresion de cysM
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2006/050033 WO2007077041A1 (en) | 2006-01-04 | 2006-01-04 | Process for the preparation of methionine and its precursors homoserine or succinylhomoserine employing a microorganism with enhanced sulfate permease expression |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR058914A1 true AR058914A1 (es) | 2008-03-05 |
Family
ID=37508334
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070100036A AR058914A1 (es) | 2006-01-04 | 2007-01-04 | Metodo para la producion de metionina mediante el cultivo de un microorganismo modificado para potenciar la produccion de cisteina |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8389250B2 (es) |
| EP (2) | EP2314710B1 (es) |
| JP (1) | JP5172697B2 (es) |
| CN (1) | CN101351558B (es) |
| AR (1) | AR058914A1 (es) |
| BR (1) | BRPI0620880B1 (es) |
| DK (1) | DK2314710T3 (es) |
| ES (1) | ES2459617T3 (es) |
| MY (1) | MY148979A (es) |
| PL (1) | PL1969130T3 (es) |
| WO (1) | WO2007077041A1 (es) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4110641B2 (ja) | 1998-11-17 | 2008-07-02 | 味の素株式会社 | 発酵法によるｌ−メチオニンの製造法 |
| WO2007077041A1 (en) * | 2006-01-04 | 2007-07-12 | Metabolic Explorer | Process for the preparation of methionine and its precursors homoserine or succinylhomoserine employing a microorganism with enhanced sulfate permease expression |
| EP2019868A2 (en) * | 2006-05-24 | 2009-02-04 | Evonik Degussa GmbH | Process for the preparation of l-methionine |
| KR100905381B1 (ko) | 2006-07-28 | 2009-06-30 | 씨제이제일제당 (주) | Ｌ-메치오닌 전구체 생산 균주 및 상기 ｌ-메치오닌전구체로부터의 ｌ-메치오닌 및 유기산의 생산방법 |
| WO2009043372A1 (en) | 2007-10-02 | 2009-04-09 | Metabolic Explorer | Increasing methionine yield |
| KR101241182B1 (ko) | 2008-03-19 | 2013-03-13 | 히라따기꼬오 가부시키가이샤 | 워크검사반송장치 |
| US9005952B2 (en) | 2008-04-04 | 2015-04-14 | Cj Cheiljedang Corporation | Microorganism producing L-methionine precursor and the method of producing L-methionine precursor using the microorganism |
| US7851180B2 (en) * | 2008-04-04 | 2010-12-14 | Cj Cheiljedang Corporation | Microorganism producing L-methionine precursor and the method of producing L-methionine precursor using the microorganism |
| WO2010022763A1 (en) * | 2008-08-25 | 2010-03-04 | Metabolic Explorer | Method for the preparation of 2-hydroxy-isobutyrate |
| WO2010020290A1 (en) * | 2008-08-22 | 2010-02-25 | Metabolic Explorer | Producing methionine without n-acetyl methionine |
| WO2010020289A1 (en) | 2008-08-22 | 2010-02-25 | Metabolic Explorer | Production of n-acetylated sulphur-containing amino acids with microorganisms having enhanced n-acetyltransferase enzymatic activity |
| KR101827230B1 (ko) | 2008-12-31 | 2018-02-07 | 메타볼릭 익스플로러 | 디올의 제조 방법 |
| JP2012223092A (ja) * | 2009-08-28 | 2012-11-15 | Ajinomoto Co Inc | Ｌ−アミノ酸の製造法 |
| US8609396B2 (en) * | 2009-08-28 | 2013-12-17 | Cj Cheiljedang Corporation | Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism |
| RU2009136544A (ru) * | 2009-10-05 | 2011-04-10 | Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) (RU) | Способ получения l-цистеина с использованием бактерии семейства enterobacteriaceae |
| FR2951195B1 (fr) | 2009-10-14 | 2014-01-31 | Roquette Freres | Composition riche en methionine destinee a l'alimentation animale |
| JP5817529B2 (ja) | 2009-11-30 | 2015-11-18 | 味の素株式会社 | Ｌ−システイン生産菌及びｌ−システインの製造法 |
| WO2011073738A1 (en) | 2009-12-14 | 2011-06-23 | Metabolic Explorer | Use of inducible promoters in the production of methionine |
| BR112012016274B1 (pt) | 2009-12-30 | 2019-08-20 | Evonik Degussa Gmbh | Aumento da produção de metionina pela superexpressão da succinato desidrogenase |
| EP2519637A2 (en) * | 2009-12-30 | 2012-11-07 | Metabolic Explorer | Strains and method for the production of methionine |
| WO2012001003A1 (en) | 2010-07-02 | 2012-01-05 | Metabolic Explorer | Method for the preparation of hydroxy acids |
| TWI500768B (zh) | 2010-07-05 | 2015-09-21 | Metabolic Explorer Sa | 由蔗糖製備１，３－丙二醇之方法 |
| BR112013006031A2 (pt) | 2010-09-14 | 2016-06-07 | Ajinomoto Kk | bactéria,e, método para produzir um aminoácido contendo enxofre, uma substância relacionada ao mesmo, ou uma mnistura dos mesmos. |
| KR101208267B1 (ko) * | 2010-10-20 | 2012-12-04 | 씨제이제일제당 (주) | Ｏ-포스포세린 설피드릴라제 변이체 |
| AR083468A1 (es) | 2010-10-25 | 2013-02-27 | Metabolic Explorer Sa | Aumento de la disponibilidad de nadph para la produccion de metionina |
| WO2012090021A1 (en) | 2010-12-30 | 2012-07-05 | Metabolic Explorer | Recombinant microorganism for the fermentative production of methionine |
| CN103429748B (zh) * | 2010-12-30 | 2016-01-06 | 代谢探索者公司 | 甲硫氨酸羟基类似物(mha)的发酵产生 |
| EP2479279A1 (de) | 2011-01-20 | 2012-07-25 | Evonik Degussa GmbH | Verfahren zur fermentativen Herstellung schwefelhaltiger Aminosäuren |
| JP2014087259A (ja) | 2011-02-22 | 2014-05-15 | Ajinomoto Co Inc | Ｌ−システイン生産菌及びｌ−システインの製造法 |
| US9234223B2 (en) | 2011-04-01 | 2016-01-12 | Ajinomoto Co., Inc. | Method for producing L-cysteine |
| WO2012137689A1 (ja) | 2011-04-01 | 2012-10-11 | 味の素株式会社 | Ｌ－システインの製造法 |
| AR086790A1 (es) * | 2011-06-29 | 2014-01-22 | Metabolic Explorer Sa | Un microorganismo para la produccion de metionina con importacion de glucosa mejorada |
| EP2540834A1 (en) | 2011-06-29 | 2013-01-02 | Metabolic Explorer | Method for the preparation of 1,3-propanediol |
| US9410164B2 (en) | 2011-10-11 | 2016-08-09 | Metabolic Explorer | Biosynthesis pathway for prenol in a recombinant microorganism |
| FR2983870B1 (fr) | 2011-12-08 | 2015-07-17 | Roquette Freres | Composition en methionine destinee a l'alimentation animale |
| EP2628792A1 (de) | 2012-02-17 | 2013-08-21 | Evonik Industries AG | Zelle mit verringerter ppGppase-Aktivität |
| EP2647718A3 (en) | 2012-04-06 | 2014-12-24 | Metabolic Explorer | Process for producing 5-aminopentanoate empolying a recombinant microorganism |
| CN104411821B (zh) | 2012-06-18 | 2017-08-08 | 代谢探索者公司 | 用于发酵生产甲硫氨酸的重组微生物 |
| EP2700715B1 (de) | 2012-08-20 | 2018-07-25 | Evonik Degussa GmbH | Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
| WO2014049382A2 (en) | 2012-09-26 | 2014-04-03 | Metabolic Explorer | Ethylenediamine fermentative production by a recombinant microorganism |
| WO2014071182A1 (en) | 2012-11-01 | 2014-05-08 | Massachusetts Institute Of Technology | Directed evolution of synthetic gene cluster |
| PE20150681A1 (es) | 2013-05-13 | 2015-05-15 | Ajinomoto Kk | Metodo para producir l-aminoacidos |
| PL3039153T3 (pl) | 2013-08-30 | 2019-02-28 | Evonik Degussa Gmbh | Mikroorganizm do wytwarzania metioniny o ulepszonej aktywności syntazy metioniny i wypływie metioniny |
| JP6459962B2 (ja) | 2013-10-21 | 2019-01-30 | 味の素株式会社 | Ｌ−アミノ酸の製造法 |
| JP6519476B2 (ja) | 2013-10-23 | 2019-05-29 | 味の素株式会社 | 目的物質の製造法 |
| JP6393898B2 (ja) * | 2014-08-03 | 2018-09-26 | 国立大学法人 奈良先端科学技術大学院大学 | 酵母の培養方法 |
| CA2959563A1 (en) | 2014-09-01 | 2016-03-10 | Metabolic Explorer | Method and microorganism for methionine production by fermentation with improved methionine efflux |
| EP3050970B1 (en) | 2015-01-28 | 2019-09-18 | Metabolic Explorer | Modified microorganism for optimized production of 1,4-butanediol |
| US10858675B2 (en) | 2015-04-07 | 2020-12-08 | Metabolic Explorer | Modified microorganism for the optimized production of 2,4-dihydroxybutyrate with enhanced 2,4-dihydroxybutyrate efflux |
| EP3095868A1 (en) | 2015-05-19 | 2016-11-23 | Evonik Degussa GmbH | Methionine production |
| EP3298156A1 (en) | 2015-07-10 | 2018-03-28 | Evonik Degussa GmbH | Amino acid production |
| EP3322679A4 (en) | 2015-07-13 | 2019-07-10 | Pivot Bio, Inc. | METHODS AND COMPOSITIONS FOR IMPROVING THE CHARACTERISTICS OF A PLANT |
| US20180223319A1 (en) | 2015-08-07 | 2018-08-09 | Evonik Degussa Gmbh | Protein thiocarboxylate-dependent l-methionine production by fermentation |
| WO2017042602A1 (en) | 2015-09-10 | 2017-03-16 | Metabolic Explorer | New lactaldehyde reductases for the production of 1,2-propanediol |
| FR3041658B1 (fr) | 2015-09-30 | 2017-10-20 | Arkema France | Procede de production de l-methionine |
| FR3041659B1 (fr) | 2015-09-30 | 2017-10-20 | Arkema France | Procede de production de l-methionine |
| EP3359664A4 (en) | 2015-10-05 | 2019-03-20 | Massachusetts Institute Of Technology | NITROGEN FIXATION WITH REINFORCED NIF CLUSTERS |
| CN108291243A (zh) | 2015-11-27 | 2018-07-17 | 赢创德固赛有限公司 | 生产l-甲硫氨酸的方法 |
| KR20180093981A (ko) | 2016-01-08 | 2018-08-22 | 에보니크 데구사 게엠베하 | 발효적 생산에 의해 l-메티오닌을 생산하는 방법 |
| EP3296404A1 (en) | 2016-09-15 | 2018-03-21 | Evonik Degussa GmbH | Modified microorganism for production of methionine |
| CN110799474B (zh) | 2017-01-12 | 2022-07-26 | 皮沃特生物公司 | 用于改良植物性状的方法及组合物 |
| JP7066977B2 (ja) | 2017-04-03 | 2022-05-16 | 味の素株式会社 | Ｌ－アミノ酸の製造法 |
| BR112020000552A2 (pt) | 2017-07-11 | 2020-07-21 | Adisseo France S.A.S. | levedura produtora de metionina |
| KR20200044015A (ko) * | 2017-08-09 | 2020-04-28 | 피벗 바이오, 인크. | 유전자조작 미생물을 개선하기 위한 방법 및 조성물 |
| EP3470512A1 (en) | 2017-10-10 | 2019-04-17 | Metabolic Explorer | Mutant phosphoserine aminotransferase for the conversion of homoserine into 4-hydroxy-2-ketobutyrate |
| CN111587287A (zh) | 2017-10-25 | 2020-08-25 | 皮沃特生物股份有限公司 | 用于改良固氮的工程微生物的方法和组合物 |
| CN112739668A (zh) | 2018-06-27 | 2021-04-30 | 皮沃特生物股份有限公司 | 包括重构固氮微生物的农业组合物 |
| WO2020067487A1 (en) | 2018-09-28 | 2020-04-02 | Ajinomoto Co., Inc. | Method for producing l-methionine using a bacterium |
| WO2020071538A1 (en) | 2018-10-05 | 2020-04-09 | Ajinomoto Co., Inc. | Method for producing target substance by bacterial fermentation |
| WO2020198258A1 (en) * | 2019-03-26 | 2020-10-01 | Zymergen Inc. | Engineered biosynthetic pathways for production of l-homocysteine by fermentation |
| KR102472559B1 (ko) * | 2019-06-28 | 2022-12-01 | 씨제이제일제당 주식회사 | 황 함유 아미노산 또는 그 유도체의 제조방법 |
| KR102472558B1 (ko) * | 2019-06-28 | 2022-12-01 | 씨제이제일제당 주식회사 | 황 함유 아미노산 또는 그 유도체 제조방법 |
| CN113388630B (zh) * | 2020-03-11 | 2022-07-26 | 华东理工大学 | 合成l-半胱氨酸的重组大肠杆菌的构建方法及其应用 |
| CN112592924B (zh) * | 2020-12-28 | 2022-07-01 | 宁夏伊品生物科技股份有限公司 | 一种yh66_10325基因改造的产l-异亮氨酸重组菌株及其构建方法与应用 |
| CN114350586B (zh) * | 2022-01-24 | 2023-07-28 | 浙江工业大学 | 高产l-半胱氨酸的基因工程菌、构建方法及应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000157267A (ja) | 1998-11-24 | 2000-06-13 | Ajinomoto Co Inc | 変異型ｍｅｔＪ遺伝子及びＬ−メチオニンの製造法 |
| US6831165B1 (en) * | 1999-06-25 | 2004-12-14 | Basf Aktiengesellschaft | Corynebacterium glutamicum genes encoding proteins involved in homeostasis and adaptation |
| AU2223601A (en) * | 1999-12-24 | 2001-07-09 | Ajinomoto Co., Inc. | Process for producing l-amino acid and novel gene |
| US7220571B2 (en) * | 2000-09-28 | 2007-05-22 | Archer-Daniels-Midland Company | Escherichia coli strains which over-produce L-threonine and processes for the production of L-threonine by fermentation |
| ES2269712T3 (es) * | 2001-07-11 | 2007-04-01 | Degussa Gmbh | Proceso para la preparacion de l-aminoacidos que utiliza cepas de la familia enterobacteriaceas. |
| EP1686184B1 (en) | 2001-07-11 | 2008-08-27 | Evonik Degussa GmbH | Process for the preparation of L-threonine using strains of the enterobacteriaceae family |
| US7160711B2 (en) * | 2001-08-06 | 2007-01-09 | Degussa Ag | Coryneform bacteria which produce chemical compounds I |
| DE10239308A1 (de) * | 2002-08-27 | 2004-03-11 | Basf Ag | Verfahren zur fermentativen Herstellung von schwefelhaltigen Feinchemikalien |
| CA2510475A1 (en) | 2002-12-20 | 2004-07-08 | Metanomics Gmbh & Co. Kgaa | Method of producing amino acids in transgenic plants comprising expressing a nucleic acid encoding a threonine decomposing protein |
| DE10305774A1 (de) | 2003-02-06 | 2004-08-26 | Consortium für elektrochemische Industrie GmbH | Verfahren zur fermentativen Herstellung von L-Methionin |
| MXPA05008857A (es) | 2003-02-18 | 2006-03-09 | Metabolic Explorer Sa | Procedimiento de preparacion de microorganismos evolucionados que permite la creacion o la modificacion de vias metabolicas. |
| WO2004108894A2 (en) | 2003-05-30 | 2004-12-16 | Microbia, Inc. | Methods and compositions for amino acid production |
| RU2275425C2 (ru) | 2003-11-03 | 2006-04-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | Бактерия, принадлежащая к роду escherichia, - продуцент l-цистеина и способ получения l-цистеина |
| DE10359668A1 (de) | 2003-12-18 | 2005-07-14 | Basf Ag | Verfahren zur Herstellung von Methionin |
| DE102004009454A1 (de) * | 2004-02-27 | 2005-09-15 | Degussa Ag | Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung von rekombinanten Mikroorganismen |
| DE102004013503A1 (de) | 2004-03-18 | 2005-10-06 | Degussa Ag | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien |
| WO2005111202A1 (en) * | 2004-05-12 | 2005-11-24 | Metabolic Explorer | Recombinant enzyme with altered feedback sensitivity |
| WO2006082254A2 (en) * | 2005-02-07 | 2006-08-10 | Metabolic Explorer | Microorganisms comprising enzymes expressed with low gamma-elimination activity |
| JP2009501550A (ja) * | 2005-07-18 | 2009-01-22 | ビーエーエスエフ ソシエタス・ヨーロピア | メチオニン生産組換え微生物 |
| WO2007077041A1 (en) * | 2006-01-04 | 2007-07-12 | Metabolic Explorer | Process for the preparation of methionine and its precursors homoserine or succinylhomoserine employing a microorganism with enhanced sulfate permease expression |
-
2006
- 2006-01-04 WO PCT/EP2006/050033 patent/WO2007077041A1/en active Application Filing
- 2006-01-04 DK DK10187418.8T patent/DK2314710T3/en active
- 2006-01-04 CN CN2006800503269A patent/CN101351558B/zh not_active Expired - Fee Related
- 2006-01-04 BR BRPI0620880A patent/BRPI0620880B1/pt not_active IP Right Cessation
- 2006-01-04 EP EP10187418.8A patent/EP2314710B1/en not_active Not-in-force
- 2006-01-04 EP EP06707666.1A patent/EP1969130B1/en not_active Not-in-force
- 2006-01-04 JP JP2008548953A patent/JP5172697B2/ja not_active Expired - Fee Related
- 2006-01-04 US US12/159,846 patent/US8389250B2/en active Active
- 2006-01-04 PL PL06707666T patent/PL1969130T3/pl unknown
- 2006-01-04 ES ES06707666.1T patent/ES2459617T3/es active Active
-
2007
- 2007-01-04 AR ARP070100036A patent/AR058914A1/es not_active Application Discontinuation
- 2007-01-04 MY MYPI20070009A patent/MY148979A/en unknown
-
2013
- 2013-01-09 US US13/737,188 patent/US9187775B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP5172697B2 (ja) | 2013-03-27 |
| US20080311632A1 (en) | 2008-12-18 |
| EP1969130A1 (en) | 2008-09-17 |
| PL1969130T3 (pl) | 2014-08-29 |
| JP2009521939A (ja) | 2009-06-11 |
| EP2314710A3 (en) | 2012-02-22 |
| DK2314710T3 (en) | 2016-06-13 |
| EP1969130B1 (en) | 2014-03-12 |
| BRPI0620880B1 (pt) | 2018-10-09 |
| EP2314710A2 (en) | 2011-04-27 |
| CN101351558A (zh) | 2009-01-21 |
| CN101351558B (zh) | 2013-08-14 |
| US20130183726A1 (en) | 2013-07-18 |
| BRPI0620880A2 (pt) | 2012-09-18 |
| MY148979A (en) | 2013-06-28 |
| ES2459617T3 (es) | 2014-05-12 |
| US9187775B2 (en) | 2015-11-17 |
| US8389250B2 (en) | 2013-03-05 |
| WO2007077041A1 (en) | 2007-07-12 |
| EP2314710B1 (en) | 2016-03-30 |
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