BRPI0715584B8 - método para produzir um l-aminoácido - Google Patents

método para produzir um l-aminoácido

Info

Publication number
BRPI0715584B8
BRPI0715584B8 BRPI0715584A BRPI0715584A BRPI0715584B8 BR PI0715584 B8 BRPI0715584 B8 BR PI0715584B8 BR PI0715584 A BRPI0715584 A BR PI0715584A BR PI0715584 A BRPI0715584 A BR PI0715584A BR PI0715584 B8 BRPI0715584 B8 BR PI0715584B8
Authority
BR
Brazil
Prior art keywords
amino acid
produce
bacterium
producing
alcohol dehydrogenase
Prior art date
Application number
BRPI0715584A
Other languages
English (en)
Inventor
Borisovna Altman Irina
Matsui Kazuhiko
Romanovich Ptitsyn Leonid
Terashita Masaru
Nikolaevna Mokhova Olga
Abramovna Yampolskaya Tatyana
Aleksandrovna Kotliarova Veronika
Usuda Yoshihiro
Ivanovich Kozlov Yury
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from RU2006125964/13A external-priority patent/RU2006125964A/ru
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of BRPI0715584A2 publication Critical patent/BRPI0715584A2/pt
Publication of BRPI0715584B1 publication Critical patent/BRPI0715584B1/pt
Publication of BRPI0715584B8 publication Critical patent/BRPI0715584B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/10—Citrulline; Arginine; Ornithine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/14—Glutamic acid; Glutamine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C12P13/222—Phenylalanine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C12P13/227—Tryptophan
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/24—Proline; Hydroxyproline; Histidine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01002—Alcohol dehydrogenase (NADP+) (1.1.1.2), i.e. aldehyde reductase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

metodo para produzir um l-aminoácido. método para produzir um l-aminoácido é descrito, por exemplo, l-treonina, l-lisina, l-histidina, l-fenilalanina, l-arginina, l-triptofano, ou ácido l-glutâmico, usando uma bactéria da família enterobaci'eriaceae, em que a bactéria tenha sido modificada para acentuar uma atividade de um álcool desidrogenase selvagem codificada pelo gene adhe ou uma álcool desidrogenase mutante que é resistente a inativação aeróbica.
BRPI0715584A 2006-07-19 2007-07-12 método para produzir um l-aminoácido BRPI0715584B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
RU2006125964/13A RU2006125964A (ru) 2006-07-19 2006-07-19 Способ получения l-аминокислот с использованием бактерии семейства enterobacteriaceae
RU2006125964 2006-07-19
US88567107P 2007-01-19 2007-01-19
US60885671 2007-01-19
PCT/JP2007/064304 WO2008010565A2 (en) 2006-07-19 2007-07-12 A method for producing an l-amino acid using a bacterium of the enterobacteriaceae family

Publications (3)

Publication Number Publication Date
BRPI0715584A2 BRPI0715584A2 (pt) 2013-03-12
BRPI0715584B1 BRPI0715584B1 (pt) 2017-01-31
BRPI0715584B8 true BRPI0715584B8 (pt) 2017-02-21

Family

ID=38957208

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0715584A BRPI0715584B8 (pt) 2006-07-19 2007-07-12 método para produzir um l-aminoácido

Country Status (6)

Country Link
US (2) US20090203090A1 (pt)
EP (1) EP2046949B1 (pt)
JP (1) JP5407858B2 (pt)
CN (2) CN101490251B (pt)
BR (1) BRPI0715584B8 (pt)
WO (1) WO2008010565A2 (pt)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2004124226A (ru) 2004-08-10 2006-01-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) Использование фосфокетолазы для продукции полезных метаболитов
US7915018B2 (en) 2004-10-22 2011-03-29 Ajinomoto Co., Inc. Method for producing L-amino acids using bacteria of the Enterobacteriaceae family
EP2351830B1 (en) 2006-03-23 2014-04-23 Ajinomoto Co., Inc. A method for producing an L-amino acid using bacterium of the Enterobacteriaceae family with attenuated expression of a gene coding for small RNA
WO2008044614A1 (en) 2006-09-28 2008-04-17 Ajinomoto Co., Inc. Method for producing 4-hydroxy-l-isoleucine
JP2010110217A (ja) * 2007-02-22 2010-05-20 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
WO2008133131A1 (ja) * 2007-04-16 2008-11-06 Ajinomoto Co., Inc. 有機酸の製造方法
JP5218400B2 (ja) * 2007-04-17 2013-06-26 味の素株式会社 カルボキシル基を有する酸性物質の製造法
RU2395579C2 (ru) 2007-12-21 2010-07-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТЫ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ, ПРИНАДЛЕЖАЩЕЙ К РОДУ Escherichia
JP2010263790A (ja) 2007-09-04 2010-11-25 Ajinomoto Co Inc アミノ酸生産微生物及びアミノ酸の製造法
JP2010226957A (ja) 2007-10-17 2010-10-14 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
RU2007147436A (ru) * 2007-12-21 2009-06-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) Бактерия-продуцент (2s,3r,4s)-4-гидрокси-l-изолейцина и способ продукции (2s,3r,4s)-4-гидрокси-l-изолейцина
RU2395580C2 (ru) * 2007-12-21 2010-07-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Способ конструирования бактерии-продуцента (2s,3r,4s)-4-гидрокси-l-изолейцина, бактерия-продуцент (2s,3r,4s)-4-гидрокси-l-изолейцина и способ продукции (2s,3r,4s)-гидрокси-l-изолейцина или его соли
EP2248906A4 (en) * 2008-01-23 2012-07-11 Ajinomoto Kk PROCESS FOR THE PREPARATION OF L-AMINO ACID
EP2138585B1 (en) * 2008-03-06 2011-02-09 Ajinomoto Co., Inc. An L-cysteine producing bacterium and a method for producing L-cysteine
JP2011167071A (ja) * 2008-05-22 2011-09-01 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
WO2010027022A1 (ja) 2008-09-05 2010-03-11 味の素株式会社 Ｌ－アミノ酸生産菌及びｌ－アミノ酸の製造法
JP2012100537A (ja) * 2009-03-06 2012-05-31 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2012223092A (ja) 2009-08-28 2012-11-15 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2013074795A (ja) 2010-02-08 2013-04-25 Ajinomoto Co Inc 変異型ｒｐｓＡ遺伝子及びＬ−アミノ酸の製造法
RU2471868C2 (ru) 2010-02-18 2013-01-10 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) Мутантная аденилатциклаза, днк, кодирующая ее, бактерия семейства enterobacteriaceae, содержащая указанную днк, и способ получения l-аминокислот
JP2013176301A (ja) * 2010-07-01 2013-09-09 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2014036576A (ja) 2010-12-10 2014-02-27 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
BR112013027845A2 (pt) * 2011-05-18 2017-01-03 Ajinomoto Kk Imunoestimulante, ração, método para produzir um imunoestimulante, e, método para imunoestimulação
RU2011134436A (ru) 2011-08-18 2013-10-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") Способ получения l-аминокислоты с использованием бактерии семейства enterobacteriaceae, обладающей повышенной экспрессией генов каскада образования флагелл и клеточной подвижности
RU2013119826A (ru) 2013-04-29 2014-11-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") Коринеформная бактерия и способ получения гетерологичных гибридных белков
CN103642765B (zh) * 2013-12-25 2015-11-18 南京工业大学 醇脱氢酶突变体及其应用
CN104004742A (zh) * 2014-04-08 2014-08-27 北京贝奥康泰医药科技有限公司 用于培养微生物表达肝素酶iii的培养基
JP2017131111A (ja) 2014-06-03 2017-08-03 味の素株式会社 Ｌ−アミノ酸の製造法
JP6835725B2 (ja) * 2015-01-27 2021-02-24 シスバイオ エ・ペー・エスＣｙｓＢｉｏ ＡｐＳ Ｌ−セリンに対して改善された耐性を有する遺伝子組換え微生物
US11737474B2 (en) 2016-02-08 2023-08-29 Cargill, Incorporated Protein concentrates from oil seeds and methods of producing the same
CN112725254B (zh) * 2017-10-13 2023-07-11 湖南利尔生物科技有限公司 一种l-高丝氨酸的生产菌株及其构建方法和应用
CN110004081B (zh) * 2019-03-25 2022-09-13 江西省科学院微生物研究所 一种能拆分(+/-)γ-内酰胺得到(+)γ-内酰胺的菠萝泛菌及其应用
JP7524909B2 (ja) 2019-04-05 2024-07-30 味の素株式会社 Ｌ－アミノ酸の製造方法
JP7461463B2 (ja) * 2019-08-28 2024-04-03 内蒙古伊品生物科技有限公司 大腸菌に基づく組換え株ならびにその構築方法および使用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU943282A1 (ru) * 1979-07-13 1982-07-15 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Способ получени L-треонина
WO1990004636A1 (en) * 1988-10-25 1990-05-03 Vsesojuzny Nauchno-Issledovatelsky Institut Genetiki I Selektsii Promyshlennykh Mikroorganizmov (Vniigenetika) Strain of bacteria escherichia coli, producer of l-threonine
JP3473042B2 (ja) * 1992-04-28 2003-12-02 味の素株式会社 変異型アスパルトキナーゼ遺伝子
US6132999A (en) * 1992-09-21 2000-10-17 Ajinomoto Co., Inc. L-threonine-producing microbacteria and a method for the production of L-threonine
US5661012A (en) * 1992-11-10 1997-08-26 Ajinomoto Co., Inc. Method for the production of L-threonine by fermentation, using mutated DNA encoding aspartokinase III
PL185681B1 (pl) * 1993-10-28 2003-07-31 Ajinomoto Kk Sposób wytwarzania L-aminokwasu przy użyciu mikroorganizmu
JPH07155184A (ja) * 1993-12-08 1995-06-20 Ajinomoto Co Inc 発酵法によるｌ−リジンの製造法
DE69534801T3 (de) * 1994-12-09 2013-05-08 Ajinomoto Co., Inc. Neues lysin decarboxylase gen und verfahren zur herstellung von l-lysin
JP4032441B2 (ja) * 1995-08-30 2008-01-16 味の素株式会社 Ｌ−アミノ酸の製造方法
JP4088982B2 (ja) * 1996-10-15 2008-05-21 味の素株式会社 発酵法によるｌ−アミノ酸の製造法
RU2144564C1 (ru) * 1998-10-13 2000-01-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" ФРАГМЕНТ ДНК rhtB, КОДИРУЮЩИЙ СИНТЕЗ БЕЛКА RhtB, ПРИДАЮЩЕГО УСТОЙЧИВОСТЬ К L-ГОМОСЕРИНУ БАКТЕРИЯМ ESCHERICHIA COLI, И СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ
RU2148642C1 (ru) * 1998-12-23 2000-05-10 ЗАО "Научно-исследовательский институт АДЖИНОМОТО-Генетика" (ЗАО "АГРИ") Фрагмент днк rhtc, кодирующий синтез белка rhtc, придающего повышенную устойчивость к l-треонину бактериям escherichia coli, и способ получения l-аминокислоты
JP2000201692A (ja) * 1999-01-13 2000-07-25 Ajinomoto Co Inc 発酵法によるｌ―グルタミン酸の製造法
JP4380029B2 (ja) * 2000-07-05 2009-12-09 味の素株式会社 微生物を利用した物質の製造法
JP4265093B2 (ja) * 2000-08-11 2009-05-20 味の素株式会社 スレオニン及びイソロイシンの製造法
RU2244007C2 (ru) * 2002-02-27 2005-01-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Способ получения l-треонина, штамм escherichia coli - продуцент треонина (варианты)
WO2005010175A1 (en) * 2003-07-29 2005-02-03 Ajinomoto Co., Inc. Method for producing l-lysine or l-threonine using escherichia bacteria having attnuated malic enzyme activity
JP4380305B2 (ja) * 2003-11-21 2009-12-09 味の素株式会社 発酵法によるｌ−アミノ酸の製造法
RU2275424C2 (ru) * 2003-12-05 2006-04-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Способ получения l-треонина с использованием бактерий, принадлежащих к роду escherichia
RU2316588C1 (ru) * 2004-01-30 2008-02-10 Адзиномото Ко., Инк. Бактерия - продуцент l-аминокислоты и способ получения l-аминокислоты (варианты)
DE102004008445A1 (de) * 2004-02-19 2005-09-08 Degussa Ag Verfahren zur Herstellung von L-Aminosäuren aus D-Aminosäuren
US7915018B2 (en) * 2004-10-22 2011-03-29 Ajinomoto Co., Inc. Method for producing L-amino acids using bacteria of the Enterobacteriaceae family
US20070004014A1 (en) * 2005-06-29 2007-01-04 Yuichiro Tsuji Method for producing l-threonine

Also Published As

Publication number Publication date
CN101490251A (zh) 2009-07-22
BRPI0715584A2 (pt) 2013-03-12
WO2008010565A3 (en) 2008-05-29
CN103215319A (zh) 2013-07-24
BRPI0715584B1 (pt) 2017-01-31
JP2009543543A (ja) 2009-12-10
JP5407858B2 (ja) 2014-02-05
US20150203881A1 (en) 2015-07-23
WO2008010565A2 (en) 2008-01-24
EP2046949B1 (en) 2014-01-15
EP2046949A2 (en) 2009-04-15
CN101490251B (zh) 2016-06-29
US20090203090A1 (en) 2009-08-13

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