BR112013006031A2 - bactéria,e, método para produzir um aminoácido contendo enxofre, uma substância relacionada ao mesmo, ou uma mnistura dos mesmos. - Google Patents

bactéria,e, método para produzir um aminoácido contendo enxofre, uma substância relacionada ao mesmo, ou uma mnistura dos mesmos.

Info

Publication number
BR112013006031A2
BR112013006031A2 BR112013006031A BR112013006031A BR112013006031A2 BR 112013006031 A2 BR112013006031 A2 BR 112013006031A2 BR 112013006031 A BR112013006031 A BR 112013006031A BR 112013006031 A BR112013006031 A BR 112013006031A BR 112013006031 A2 BR112013006031 A2 BR 112013006031A2
Authority
BR
Brazil
Prior art keywords
amino acid
sulfur
containing amino
mixture
producing
Prior art date
Application number
BR112013006031A
Other languages
English (en)
Inventor
Gen Nonaka
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of BR112013006031A2 publication Critical patent/BR112013006031A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
    • C12R2001/19—Escherichia coli

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

bactéria,e, método para produzir um aminoácido contendo enxofre, uma substância relacionada ao mesmo, ou uma mistura dos mesmos. é desenvolvida uma técnica nova para melhorar a capacidade de uma bactéria para produzir aminoácido contendo enxofre, e com isso são fornecidos uma bactéria produtora de aminoácido contendo enxofre, e um método para produzir um composto tal como um aminoácido contendo enxofre. um aminoácido contendo enxofre, uma substância relacionada ao mesmo, ou uma mistura dos mesmos é produzido (a) pela cultura de uma bactéria que pertence à família enterobacteriaceae, que tem uma capacidade para produzir aminoácido contendo enxofre e tem sido modificada de modo que a atividade para produzir a proteína codificada pelo gene yeee, por exemplo, a proteína do seguinte (a) ou (b), seja aumentada em um meio, e coleta de um aminoácido contendo enxofre, de uma substância relacionada ao mesmo, ou de uma mistura dos mesmos do meio: (a) uma proteína conisistindo da szequência de aminoácidos de seq id no: 14, (b) uma proteína consistindo da sequência de aminoácidos de seq id no: 14 incluindo substituição, deleçãop, inserção, ou adição de um ou vários resíduos de aminoácidos, e cuja atividade intracelular aumentadamelhora a capacidade de produzir aminoácido contendo enxofre.
BR112013006031A 2010-09-14 2011-09-13 bactéria,e, método para produzir um aminoácido contendo enxofre, uma substância relacionada ao mesmo, ou uma mnistura dos mesmos. BR112013006031A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010205019 2010-09-14
PCT/JP2011/070850 WO2012036151A1 (ja) 2010-09-14 2011-09-13 含硫アミノ酸生産菌及び含硫アミノ酸の製造法

Publications (1)

Publication Number Publication Date
BR112013006031A2 true BR112013006031A2 (pt) 2016-06-07

Family

ID=45831610

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013006031A BR112013006031A2 (pt) 2010-09-14 2011-09-13 bactéria,e, método para produzir um aminoácido contendo enxofre, uma substância relacionada ao mesmo, ou uma mnistura dos mesmos.

Country Status (6)

Country Link
US (1) US8962284B2 (pt)
EP (1) EP2617808B1 (pt)
JP (1) JP5803927B2 (pt)
CN (1) CN103119154B (pt)
BR (1) BR112013006031A2 (pt)
WO (1) WO2012036151A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103119154B (zh) 2010-09-14 2015-11-25 味之素株式会社 含硫氨基酸生产菌以及含硫氨基酸的制造方法
DE102012216527A1 (de) * 2012-09-17 2014-03-20 Wacker Chemie Ag Verfahren zur fermentativen Produktion von L-Cystein und Derivaten dieser Aminosäure
WO2015033849A1 (ja) * 2013-09-04 2015-03-12 国立大学法人奈良先端科学技術大学院大学 Ｌ―システインの製造方法
CN105671074B (zh) * 2016-03-04 2019-06-14 四川省农业科学院生物技术核技术研究所 一种提高植物甲硫氨酸含量的载体及其构建方法和用途
BR112021017870A2 (pt) 2019-04-05 2021-12-07 Ajinomoto Kk Método para produzir um l-aminoácido

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56144092A (en) 1980-04-14 1981-11-10 Ajinomoto Co Inc Preparation of l-methionine by fermentation
FR2627508B1 (fr) 1988-02-22 1990-10-05 Eurolysine Procede pour l'integration d'un gene choisi sur le chromosome d'une bacterie et bacterie obtenue par ledit procede
US5856148A (en) 1991-12-12 1999-01-05 Wacker Chemie Gmbh Materials and methods for biosynthesis of serine and serine-related products
DE4232468A1 (de) 1992-09-28 1994-03-31 Consortium Elektrochem Ind Mikroorganismen für die Produktion von Tryptophan und Verfahren zu ihrer Herstellung
EP0647712A1 (en) 1993-10-07 1995-04-12 Boehringer Ingelheim Espana S.A. Production of S-adenosyl-methionine (SAM) by fermentation of transformed bacteria
DE19539952A1 (de) 1995-10-26 1997-04-30 Consortium Elektrochem Ind Verfahren zur Herstellung von O-Acetylserin, L-Cystein und L-Cystein-verwandten Produkten
DE19726083A1 (de) 1997-06-19 1998-12-24 Consortium Elektrochem Ind Mikroorganismen und Verfahren zur fermentativen Herstellung von L-Cystein, L-Cystin, N-Acetyl-Serin oder Thiazolidinderivaten
JP4151094B2 (ja) 1997-11-25 2008-09-17 味の素株式会社 Ｌ−システインの製造法
AU756507B2 (en) 1998-03-18 2003-01-16 Ajinomoto Co., Inc. L-glutamic acid-producing bacterium and method for producing L-glutamic acid
WO2000018935A1 (fr) 1998-09-25 2000-04-06 Ajinomoto Co.,Inc. Procede de construction d'une bacterie produisant des acides amines, et procede de production d'acides amines par une technique de fermentation utilisant ladite bacterie
JP4110641B2 (ja) 1998-11-17 2008-07-02 味の素株式会社 発酵法によるｌ−メチオニンの製造法
RU2175351C2 (ru) 1998-12-30 2001-10-27 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО "АГРИ") Фрагмент днк из escherichia coli, определяющий повышенную продукцию l-аминокислот (варианты), и способ получения l-аминокислот
DE19949579C1 (de) 1999-10-14 2000-11-16 Consortium Elektrochem Ind Verfahren zur fermentativen Herstellung von L-Cystein oder L-Cystein-Derivaten
JP4622111B2 (ja) 2001-02-09 2011-02-02 味の素株式会社 Ｌ−システイン生産菌及びｌ−システインの製造法
RU2215782C2 (ru) 2001-02-26 2003-11-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ, ШТАММ Escherichia coli - ПРОДУЦЕНТ L-АМИНОКИСЛОТЫ (ВАРИАНТЫ)
JP2002238592A (ja) 2001-02-20 2002-08-27 Ajinomoto Co Inc Ｌ−グルタミン酸の製造法
JP2003010654A (ja) 2001-04-24 2003-01-14 Kuraray Co Ltd 中空糸膜の製造方法
RU2209248C2 (ru) 2001-06-26 2003-07-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Способ получения l-метионина, штамм бактерии escherichia coli вкпм в-8125 - продуцент l-метионина
JP4186564B2 (ja) 2001-09-28 2008-11-26 味の素株式会社 Ｌ−システイン生産菌及びｌ−システインの製造法
DE10232930A1 (de) 2002-07-19 2004-02-05 Consortium für elektrochemische Industrie GmbH Verfahren zur fermentativen Herstellung von Aminosäuren und Aminosäure-Derivaten der Phosphoglycerat-Familie
DE10309856A1 (de) 2003-03-06 2004-09-23 Consortium für elektrochemische Industrie GmbH Verfahren zur fermentativen Herstellung von S-Adenosylmethionin
DE10331291A1 (de) 2003-07-10 2005-02-17 Consortium für elektrochemische Industrie GmbH Varianten der 3-Phosphoglyceratdehydrogenase mit reduzierter Hemmung durch L-Serin und dafür codierende Gene
EP1650296B1 (en) 2003-07-16 2012-04-18 Ajinomoto Co., Inc. Mutant serine acetyltransferase and process for producing l-cysteine
EP1649403A2 (en) 2003-07-29 2006-04-26 Ajinomoto Co., Inc. Method for determining metabolic flux affecting substance production
RU2275425C2 (ru) 2003-11-03 2006-04-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Бактерия, принадлежащая к роду escherichia, - продуцент l-цистеина и способ получения l-цистеина
JP2005168422A (ja) 2003-12-12 2005-06-30 Kazumi Araki 発酵法によるｌ−シスタチオニンの製造法
JP4479283B2 (ja) 2004-03-04 2010-06-09 味の素株式会社 Ｌ−システイン生産菌及びｌ−システインの製造法
JP4604537B2 (ja) 2004-03-31 2011-01-05 味の素株式会社 Ｌ−システイン生産菌及びｌ−システインの製造法
WO2005111202A1 (en) 2004-05-12 2005-11-24 Metabolic Explorer Recombinant enzyme with altered feedback sensitivity
DE102005009751A1 (de) 2005-03-03 2006-09-07 Consortium für elektrochemische Industrie GmbH Verfahren zur fermentativen Herstellung von S-Adenosyl-Methionin
JP5172697B2 (ja) 2006-01-04 2013-03-27 メタボリック エクスプローラー 硫酸透過酵素の発現が増強された微生物を用いてメチオニンおよびその前駆体ホモセリンまたはスクシニルホモセリンを製造するための方法
RU2355763C2 (ru) 2006-09-13 2009-05-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Мутантная ацетолактатсинтаза и способ продукции разветвленных l-аминокислот
WO2009104731A1 (ja) 2008-02-21 2009-08-27 味の素株式会社 Ｌ－システイン生産菌及びｌ－システインの製造法
JP5332237B2 (ja) 2008-03-06 2013-11-06 味の素株式会社 Ｌ−システイン生産菌及びｌ−システインの製造法
US8383372B2 (en) 2008-03-06 2013-02-26 Ajinomoto Co., Inc. L-cysteine producing bacterium and a method for producing L-cysteine
JP5598329B2 (ja) 2008-09-08 2014-10-01 味の素株式会社 Ｌ−アミノ酸を生産する微生物及びｌ−アミノ酸の製造法
JP5521347B2 (ja) 2009-02-16 2014-06-11 味の素株式会社 Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
JP5463528B2 (ja) 2009-02-25 2014-04-09 味の素株式会社 Ｌ−システイン生産菌及びｌ−システインの製造法
JP5359409B2 (ja) 2009-03-12 2013-12-04 味の素株式会社 Ｌ−システイン生産菌及びｌ−システインの製造法
ES2646165T3 (es) 2009-11-30 2017-12-12 Ajinomoto Co., Inc. Bacteria que produce L-cisteína y procedimiento para la producción de L-cisteína
RU2460793C2 (ru) 2010-01-15 2012-09-10 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) Способ получения l-аминокислот с использованием бактерий семейства enterobacteriaceae
CN103119154B (zh) 2010-09-14 2015-11-25 味之素株式会社 含硫氨基酸生产菌以及含硫氨基酸的制造方法
US9234223B2 (en) 2011-04-01 2016-01-12 Ajinomoto Co., Inc. Method for producing L-cysteine

Also Published As

Publication number Publication date
US20130164793A1 (en) 2013-06-27
JP5803927B2 (ja) 2015-11-04
EP2617808A1 (en) 2013-07-24
JPWO2012036151A1 (ja) 2014-02-03
CN103119154A (zh) 2013-05-22
WO2012036151A1 (ja) 2012-03-22
EP2617808A4 (en) 2014-02-19
EP2617808B1 (en) 2016-06-15
CN103119154B (zh) 2015-11-25
US8962284B2 (en) 2015-02-24

Similar Documents

Publication Publication Date Title
Qiu et al. Enterobacter aerogenes ZDY01 attenuates choline-induced trimethylamine N-oxide levels by remodeling gut microbiota in mice
Hotze et al. Identification and characterization of the first cholesterol-dependent cytolysins from Gram-negative bacteria
BR112012015410A2 (pt) genes diacilglicerol aciltransferase e uso dos mesmos.
DE602007005233D1 (de) Verfahren zur herstellung von l-aminosäure
BR112012033699A2 (pt) polipeptídeo tendo atividade beta-glicosidase e seus usos
BR112013006031A2 (pt) bactéria,e, método para produzir um aminoácido contendo enxofre, uma substância relacionada ao mesmo, ou uma mnistura dos mesmos.
BR112015022971A2 (pt) métodos de fabricação para controlar o teor de lisina c-terminal, galactose e ácido siálico em proteínas recombinantes
BR112015029601A2 (pt) produção de diterpeno extracelular
BR112012033404A2 (pt) polipetídeo tendo ou auxiliando a atividade de degradação de material de carboidratos e uso dos mesmos.
BR112015010134A2 (pt) Processo para consumo de acetato durante a fermentação etanólica de matérias-primas celulósicas
BR112016000745A2 (pt) Processo para a preparação de rebaudiosídeo m
BR112013009583A2 (pt) ácido nucleico, vetor, célula hospedeira, métodos de preparação de uma linhagem bacteriana variante de tipificação, de marcação, de geração e de controle de populações bacterianas, linhagem e célula bacteriana variante, kit, uso de um ácido nucleico, cultivo celular, produto, processo de preparação de produtos, mutantes de fago e mutante de escape de fago
Williams et al. Cold adaptation of the Antarctic haloarchaea Halohasta litchfieldiae and Halorubrum lacusprofundi
MX2011008495A (es) Formulaciones de caldo de fermentacion.
MX2011000793A (es) Metodos, sistemas y composiciones para incrementada tolerancia de microorganismos a y produccion de acido 3-hidroxipropionico (3-hp).
BR112013009552A2 (pt) produção de butanol a partir de monóxido de carbono por um micro-organismo recombinante
DE602005020498D1 (de) Verfahren zur herstellung einer l-aminosäure unter verwendung eines bakteriums der familie enterobacteriaceae mit abgeschwächter expression des yafa-gens
BR102012012673A8 (pt) célula ns0 modificada, métodos de produzir uma proteína recombinante, de obter uma célula hospedeira de mamífero, de sanitizar uma coluna de cromatografia com afinidade para proteína a e de tratar um paciente sofrendo de esclerose múltipla, vetor, composição, processos para colher uma proteína recombinante de uma cultura de célula e para produzir uma composição purificada de daclizumab, meios, e, tampão
WO2008072761A3 (en) Method for producing an l-amino acid
BR112012033714A2 (pt) polipeptídeo com atividade de acetil xilano esterase e seus usos.
WO2007086618A8 (en) L-amino acid producing bacterium and method of producing l-amino acid
BR112014010448A2 (pt) microorganismos e métodos para a produção de caprolactona
BR112015013349A2 (pt) trieptanoína para o tratamento de deficiência de transportador de glicose 1
BR112012012915A2 (pt) bactéria pertencente à família enterobacteriaceae, e, método para produção de l-cisteína, l-cistina, um derivado das mesmas, ou uma mistura das mesmas
ATE417119T1 (de) Verfahren zur herstellung einer nichtaromatischen l-aminosäure unter verwendung eines bakteriums der familie enterobacteriaceae mit abgeschwächter expression des csra-gens

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements