BR112015013349A2 - trieptanoína para o tratamento de deficiência de transportador de glicose 1 - Google Patents
trieptanoína para o tratamento de deficiência de transportador de glicose 1Info
- Publication number
- BR112015013349A2 BR112015013349A2 BR112015013349A BR112015013349A BR112015013349A2 BR 112015013349 A2 BR112015013349 A2 BR 112015013349A2 BR 112015013349 A BR112015013349 A BR 112015013349A BR 112015013349 A BR112015013349 A BR 112015013349A BR 112015013349 A2 BR112015013349 A2 BR 112015013349A2
- Authority
- BR
- Brazil
- Prior art keywords
- trieptanoin
- treatment
- glucose transporter
- transporter deficiency
- fatty acid
- Prior art date
Links
- 230000007812 deficiency Effects 0.000 title abstract 3
- 102000018711 Facilitative Glucose Transport Proteins Human genes 0.000 title abstract 2
- 108091052347 Glucose transporter family Proteins 0.000 title abstract 2
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 2
- 229930195729 fatty acid Natural products 0.000 abstract 2
- 239000000194 fatty acid Substances 0.000 abstract 2
- 150000004665 fatty acids Chemical class 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/02—Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computerised tomographs
- A61B6/037—Emission tomography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/50—Clinical applications
- A61B6/501—Clinical applications involving diagnosis of head, e.g. neuroimaging, craniography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/64—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving ketones
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
resumo trieptanoína para o tratamento de deficiência de transportador de glicose 1 são fornecidos métodos para tratar glut1 e deficiências energéticas cerebrais relacionadas que compreendem administrar fontes de ácidos graxos com número ímpar de carbonos, por exemplo, fontes de ácidos graxos c5 ou c7 e composições relacionadas. 1/1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261737013P | 2012-12-13 | 2012-12-13 | |
US201361779942P | 2013-03-13 | 2013-03-13 | |
PCT/US2013/075146 WO2014093901A1 (en) | 2012-12-13 | 2013-12-13 | Triheptanoin for the treatment of glucose transporter 1 deficiency |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015013349A2 true BR112015013349A2 (pt) | 2017-07-11 |
Family
ID=50935011
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015013349A BR112015013349A2 (pt) | 2012-12-13 | 2013-12-13 | trieptanoína para o tratamento de deficiência de transportador de glicose 1 |
Country Status (13)
Country | Link |
---|---|
US (3) | US9468229B2 (pt) |
EP (1) | EP2931269B1 (pt) |
JP (2) | JP2016504323A (pt) |
KR (1) | KR20150095704A (pt) |
CN (1) | CN104955450A (pt) |
AU (2) | AU2013358951C1 (pt) |
BR (1) | BR112015013349A2 (pt) |
CA (1) | CA2894456C (pt) |
ES (1) | ES2728727T3 (pt) |
HK (1) | HK1216717A1 (pt) |
IL (1) | IL239330B (pt) |
MX (1) | MX2015007584A (pt) |
WO (1) | WO2014093901A1 (pt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1929995A1 (en) | 2006-12-04 | 2008-06-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anaplerotic therapy of Huntington disease and other polyglutamine diseases |
KR20150095704A (ko) | 2012-12-13 | 2015-08-21 | 베일러 리서치 인스티튜트 | 글루코스 수송체 1 결핍증의 치료를 위한 트라이헵타노인 |
MY177028A (en) | 2013-11-14 | 2020-09-02 | Ultragenyx Pharmaceutical Inc | Solid compositions of triglycerides and uses thereof |
EP3689343A1 (en) | 2013-11-14 | 2020-08-05 | The University of Queensland | Neurodegenerative disorders and methods of treatment and diagnosis thereof using anaplerotic agents |
JP2017521464A (ja) * | 2014-07-24 | 2017-08-03 | バイエル・ファルマ・アクティエンゲゼルシャフト | グルコース輸送阻害剤 |
WO2016164521A1 (en) * | 2015-04-07 | 2016-10-13 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Compositions and methods for treatment of movement disorders |
US11337945B2 (en) | 2016-06-01 | 2022-05-24 | Keto Innovations, Llc | C5 ketone compositions, and related methods, for therapeutic and performance supplementation |
KR20190017873A (ko) | 2016-06-08 | 2019-02-20 | 썬리겐 헬쓰케어 아게 | 홀수의 탄소 원자를 갖는 지질 및 제약 조성물 또는 영양 보충제로서의 그의 용도 |
US11350870B2 (en) * | 2017-06-20 | 2022-06-07 | The Board Of Trustees Of The University Of Illinois | Method of identifying epileptic brain regions |
WO2019098377A1 (ja) | 2017-11-20 | 2019-05-23 | 富士通化成株式会社 | 複合伝熱部材、及び複合伝熱部材の製造方法 |
WO2020127178A1 (en) * | 2018-12-18 | 2020-06-25 | Société des Produits Nestlé S.A. | Dietary propionate |
EP3845229A1 (en) * | 2019-12-30 | 2021-07-07 | Gliapharm SA | Isoquinoline derivatives for use in treating glut1 deficiency syndrome |
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US4025649A (en) | 1974-08-19 | 1977-05-24 | Labaz | Acetic acid derivatives having pharmacological activity and compositions containing the same |
DE3032300A1 (de) | 1980-08-27 | 1982-04-01 | Alfred Ing. Wien Lohninger | Mittel zur parenteralen ernaehrung |
GB2104079B (en) | 1981-08-14 | 1985-08-21 | London Polytech | New aminoacid isomers, their production and their medicinal use |
US4753963A (en) | 1985-09-26 | 1988-06-28 | The Procter & Gamble Company | Nutritional fat suitable for enteral and parenteral products |
JP3486778B2 (ja) | 1993-04-02 | 2004-01-13 | 三菱ウェルファーマ株式会社 | アルツハイマー病予防治療剤 |
US20090253781A1 (en) | 2002-05-24 | 2009-10-08 | Btg International Limited | Therapeutic compositions |
US6740679B1 (en) | 1999-02-05 | 2004-05-25 | Baylor University Medical Center | Nutritional supplement or pharmaceutical preparation comprising triglycerides with seven-carbon fatty acid |
JP4902906B2 (ja) | 1999-02-05 | 2012-03-21 | ベイラー リサーチ インスティテュート | 炭素数が7である脂肪酸を含むトリグリセリドを含有する栄養補助剤または医薬調製物 |
WO2001032168A1 (en) | 1999-11-03 | 2001-05-10 | Juvenon, Inc. | Method of treating benign forgetfulness |
US6835750B1 (en) | 2000-05-01 | 2004-12-28 | Accera, Inc. | Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II |
ES2323940T3 (es) | 2000-05-01 | 2009-07-28 | Accera, Inc. | Uso de trigliceridos de cadena media para el tratamiento y prevencion de la enfermedad de alzheimer. |
CA2517929A1 (en) | 2003-03-06 | 2004-09-16 | Accera Inc. | Novel-chemical entities and methods for their use in treatment of metabolic disorders |
EP1628622A4 (en) | 2003-05-20 | 2008-12-17 | Baylor Res Inst | FIVE AND FIFTH CARBON FATTY ACIDS FOR THE TREATMENT OF METABOLISM DISORDERS AND AS FOOD SUPPLEMENTS |
CA2784420C (en) | 2004-07-02 | 2020-11-10 | Baylor Research Institute | Glycogen or polysaccharide storage disease treatment method |
WO2006037069A1 (en) | 2004-09-28 | 2006-04-06 | Allergan, Inc. | Compositions comprising nb-dnj, ne-dnj or d-glucaro-delta-lactam and their uses for the treatment of pain and other neurological conditions |
EP2338881A1 (en) | 2005-02-23 | 2011-06-29 | Prexa Pharmaceuticals, Inc. | Dopamine transporter inhibitors for use in treatment of movement disorders and other CNS indications |
US7951377B2 (en) | 2005-08-23 | 2011-05-31 | Los Alamos National Security, Llc | Mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens |
HUE040002T2 (hu) | 2006-04-03 | 2019-02-28 | Accera Inc | Ketogén vegyületek alkalmazása korfüggõ memóriazavar kezelésére |
KR20090074221A (ko) | 2006-09-26 | 2009-07-06 | 베일러 리서치 인스티튜트 | 영양물 센서 |
EP1929995A1 (en) | 2006-12-04 | 2008-06-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anaplerotic therapy of Huntington disease and other polyglutamine diseases |
PT2650381T (pt) | 2007-07-31 | 2016-12-29 | Accera Inc | Utilização de testagem genómica e compostos cetogénicos para o tratamento de função cognitiva reduzida |
WO2009124250A1 (en) | 2008-04-03 | 2009-10-08 | The Trustees Of The University Of Pennsylvania | Compositions and methods for detecting tricarboxylic acid (tca) metabolic flux |
MX348036B (es) * | 2009-12-30 | 2017-05-24 | Baylor Res Institute | Terapia anaplerótica para la enfermedad de alzheimer y el cerebro envejecido. |
US20110301238A1 (en) * | 2010-06-02 | 2011-12-08 | Borges Karin | Seizure related disorders and therapeutic methods thereof |
US20110306663A1 (en) | 2010-06-14 | 2011-12-15 | Baylor Research Institute | Triheptanoin diet for adult polyglucosan body disease (apbd) treatment |
KR101955001B1 (ko) | 2010-12-23 | 2019-03-07 | 아마젠티스 에스에이 | 미토콘드리아 기능을 개선하고 신경퇴화 질환들 및 인지 장애들을 치료하는 조성물들 및 방법들 |
EP2599482A1 (en) | 2011-11-30 | 2013-06-05 | Lunamed AG | Low dose therapeutic use of glyceryl tri-(4-phenylbutyrate) |
KR20150095704A (ko) | 2012-12-13 | 2015-08-21 | 베일러 리서치 인스티튜트 | 글루코스 수송체 1 결핍증의 치료를 위한 트라이헵타노인 |
EP3689343A1 (en) | 2013-11-14 | 2020-08-05 | The University of Queensland | Neurodegenerative disorders and methods of treatment and diagnosis thereof using anaplerotic agents |
WO2016164521A1 (en) | 2015-04-07 | 2016-10-13 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Compositions and methods for treatment of movement disorders |
-
2013
- 2013-12-13 KR KR1020157016715A patent/KR20150095704A/ko not_active Application Discontinuation
- 2013-12-13 BR BR112015013349A patent/BR112015013349A2/pt not_active Application Discontinuation
- 2013-12-13 CA CA2894456A patent/CA2894456C/en active Active
- 2013-12-13 WO PCT/US2013/075146 patent/WO2014093901A1/en active Application Filing
- 2013-12-13 US US14/106,078 patent/US9468229B2/en active Active
- 2013-12-13 EP EP13862044.8A patent/EP2931269B1/en active Active
- 2013-12-13 CN CN201380064648.9A patent/CN104955450A/zh active Pending
- 2013-12-13 MX MX2015007584A patent/MX2015007584A/es active IP Right Grant
- 2013-12-13 JP JP2015548016A patent/JP2016504323A/ja active Pending
- 2013-12-13 ES ES13862044T patent/ES2728727T3/es active Active
- 2013-12-13 AU AU2013358951A patent/AU2013358951C1/en active Active
-
2015
- 2015-06-10 IL IL239330A patent/IL239330B/en active IP Right Grant
-
2016
- 2016-04-21 HK HK16104584.6A patent/HK1216717A1/zh unknown
- 2016-09-06 US US15/257,363 patent/US10111848B2/en active Active
-
2018
- 2018-04-03 AU AU2018202336A patent/AU2018202336A1/en not_active Abandoned
- 2018-06-01 JP JP2018106014A patent/JP2018131470A/ja active Pending
- 2018-10-23 US US16/168,580 patent/US20190290610A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
IL239330A0 (en) | 2015-07-30 |
AU2013358951C1 (en) | 2019-06-27 |
EP2931269B1 (en) | 2019-05-15 |
US20140221482A1 (en) | 2014-08-07 |
KR20150095704A (ko) | 2015-08-21 |
US9468229B2 (en) | 2016-10-18 |
US20160374980A1 (en) | 2016-12-29 |
CA2894456C (en) | 2022-06-28 |
AU2018202336A1 (en) | 2018-04-26 |
ES2728727T3 (es) | 2019-10-28 |
JP2016504323A (ja) | 2016-02-12 |
EP2931269A4 (en) | 2016-07-27 |
IL239330B (en) | 2018-05-31 |
AU2013358951A1 (en) | 2015-07-02 |
AU2013358951B2 (en) | 2018-02-01 |
CN104955450A (zh) | 2015-09-30 |
WO2014093901A1 (en) | 2014-06-19 |
US10111848B2 (en) | 2018-10-30 |
MX2015007584A (es) | 2016-03-15 |
EP2931269A1 (en) | 2015-10-21 |
HK1216717A1 (zh) | 2016-12-02 |
JP2018131470A (ja) | 2018-08-23 |
CA2894456A1 (en) | 2014-06-19 |
US20190290610A1 (en) | 2019-09-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B06I | Publication of requirement cancelled [chapter 6.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA. |
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B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
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