BR112019000360A2 - método e microrganismo geneticamente modificado para a produção de metionina ou sua forma análoga de hidróxi - Google Patents

método e microrganismo geneticamente modificado para a produção de metionina ou sua forma análoga de hidróxi

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Publication number
BR112019000360A2
BR112019000360A2 BR112019000360A BR112019000360A BR112019000360A2 BR 112019000360 A2 BR112019000360 A2 BR 112019000360A2 BR 112019000360 A BR112019000360 A BR 112019000360A BR 112019000360 A BR112019000360 A BR 112019000360A BR 112019000360 A2 BR112019000360 A2 BR 112019000360A2
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Brazil
Prior art keywords
methionine
hydroxy
production
genetically modified
analogous form
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Application number
BR112019000360A
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English (en)
Inventor
Raynaud Céline
Bestel-Corre Gwenaëlle
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Evonik Degussa Gmbh
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Publication date
Application filed by Evonik Degussa Gmbh filed Critical Evonik Degussa Gmbh
Publication of BR112019000360A2 publication Critical patent/BR112019000360A2/pt

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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06—Ethanol, i.e. non-beverage
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
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    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11003—Dephospho-[reductase kinase] kinase (2.7.11.3)
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    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
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    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/09—Phosphotransferases with paired acceptors (2.7.9)
    • C12Y207/09002—Pyruvate, water dikinase (2.7.9.2)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Botany (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

a presente invenção se refere a um novo método para a produção de metionina ou sua forma análoga de hidróxi por conversão de uma fonte de carbono em um processo fermentativo que compreende cultivar um microrganismo geneticamente modificado para a produção de metionina ou sua forma análoga de hidróxi, em que o dito microrganismo compreende genes funcionais que codificam o sistema de utilização de carboidrato de pts e em que a expressão de proteínas que regulou a expressão de sintase de fosfoenolpiruvato (pps) é regulada de modo decrescente. a presente invenção também se refere ao microrganismo geneticamente modificado usado no método da invenção.
BR112019000360A 2016-07-08 2017-07-06 método e microrganismo geneticamente modificado para a produção de metionina ou sua forma análoga de hidróxi BR112019000360A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2016001123 2016-07-08
PCT/EP2017/067036 WO2018007565A1 (en) 2016-07-08 2017-07-06 Method for the fermentative production of methionine or its hydroxy analog form by microorganisms comprising genes coding sugar phosphotransferase system (pts)

Publications (1)

Publication Number Publication Date
BR112019000360A2 true BR112019000360A2 (pt) 2019-04-24

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BR112019000360A BR112019000360A2 (pt) 2016-07-08 2017-07-06 método e microrganismo geneticamente modificado para a produção de metionina ou sua forma análoga de hidróxi
BR112019000132A BR112019000132A2 (pt) 2016-07-08 2017-07-06 método para a produção fermentativa de moléculas de interesse por microrganismos compreendendo genes que codificam sistema de fosfotransferase de açúcar

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US (2) US20190276859A1 (pt)
EP (2) EP3481851B1 (pt)
JP (1) JP7321089B2 (pt)
KR (2) KR20190026851A (pt)
CN (2) CN109415417A (pt)
AU (1) AU2017291975B2 (pt)
BR (2) BR112019000360A2 (pt)
CA (1) CA3028871A1 (pt)
MX (1) MX2019000075A (pt)
RU (1) RU2760290C1 (pt)
WO (2) WO2018007565A1 (pt)

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CN109468254B (zh) * 2018-11-13 2021-03-26 江南大学 一种提高l-丙氨酸生产效率的方法及其应用
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AU2017291975B2 (en) 2021-06-03
RU2760290C1 (ru) 2021-11-23
WO2018007565A1 (en) 2018-01-11
KR20190025969A (ko) 2019-03-12
US10961499B2 (en) 2021-03-30
EP3481850A1 (en) 2019-05-15
CA3028871A1 (en) 2018-01-11
KR102430878B1 (ko) 2022-08-09
CN109415417A (zh) 2019-03-01
US20190276794A1 (en) 2019-09-12
WO2018007560A1 (en) 2018-01-11
CN109415418B (zh) 2024-02-09
US20190276859A1 (en) 2019-09-12
CN109415418A (zh) 2019-03-01
BR112019000132A2 (pt) 2019-04-16
EP3481851B1 (en) 2021-11-24
AU2017291975A1 (en) 2019-01-24
KR20190026851A (ko) 2019-03-13
JP7321089B2 (ja) 2023-08-04
MX2019000075A (es) 2019-05-02
EP3481851A1 (en) 2019-05-15
JP2019520081A (ja) 2019-07-18

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