BR112019000360A2 - método e microrganismo geneticamente modificado para a produção de metionina ou sua forma análoga de hidróxi - Google Patents

método e microrganismo geneticamente modificado para a produção de metionina ou sua forma análoga de hidróxi

Info

Publication number
BR112019000360A2
BR112019000360A2 BR112019000360A BR112019000360A BR112019000360A2 BR 112019000360 A2 BR112019000360 A2 BR 112019000360A2 BR 112019000360 A BR112019000360 A BR 112019000360A BR 112019000360 A BR112019000360 A BR 112019000360A BR 112019000360 A2 BR112019000360 A2 BR 112019000360A2
Authority
BR
Brazil
Prior art keywords
methionine
hydroxy
production
genetically modified
analogous form
Prior art date
Application number
BR112019000360A
Other languages
English (en)
Inventor
Raynaud Céline
Bestel-Corre Gwenaëlle
Original Assignee
Evonik Degussa Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Degussa Gmbh filed Critical Evonik Degussa Gmbh
Publication of BR112019000360A2 publication Critical patent/BR112019000360A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1294—Phosphotransferases with paired acceptors (2.7.9)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06—Ethanol, i.e. non-beverage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11003—Dephospho-[reductase kinase] kinase (2.7.11.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
    • C12R2001/19—Escherichia coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/09—Phosphotransferases with paired acceptors (2.7.9)
    • C12Y207/09002—Pyruvate, water dikinase (2.7.9.2)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Botany (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

a presente invenção se refere a um novo método para a produção de metionina ou sua forma análoga de hidróxi por conversão de uma fonte de carbono em um processo fermentativo que compreende cultivar um microrganismo geneticamente modificado para a produção de metionina ou sua forma análoga de hidróxi, em que o dito microrganismo compreende genes funcionais que codificam o sistema de utilização de carboidrato de pts e em que a expressão de proteínas que regulou a expressão de sintase de fosfoenolpiruvato (pps) é regulada de modo decrescente. a presente invenção também se refere ao microrganismo geneticamente modificado usado no método da invenção.
BR112019000360A 2016-07-08 2017-07-06 método e microrganismo geneticamente modificado para a produção de metionina ou sua forma análoga de hidróxi BR112019000360A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2016001123 2016-07-08
PCT/EP2017/067036 WO2018007565A1 (en) 2016-07-08 2017-07-06 Method for the fermentative production of methionine or its hydroxy analog form by microorganisms comprising genes coding sugar phosphotransferase system (pts)

Publications (1)

Publication Number Publication Date
BR112019000360A2 true BR112019000360A2 (pt) 2019-04-24

Family

ID=56741149

Family Applications (2)

Application Number Title Priority Date Filing Date
BR112019000360A BR112019000360A2 (pt) 2016-07-08 2017-07-06 método e microrganismo geneticamente modificado para a produção de metionina ou sua forma análoga de hidróxi
BR112019000132A BR112019000132A2 (pt) 2016-07-08 2017-07-06 método para a produção fermentativa de moléculas de interesse por microrganismos compreendendo genes que codificam sistema de fosfotransferase de açúcar

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR112019000132A BR112019000132A2 (pt) 2016-07-08 2017-07-06 método para a produção fermentativa de moléculas de interesse por microrganismos compreendendo genes que codificam sistema de fosfotransferase de açúcar

Country Status (11)

Country Link
US (2) US10961499B2 (pt)
EP (2) EP3481851B1 (pt)
JP (1) JP7321089B2 (pt)
KR (2) KR102430878B1 (pt)
CN (2) CN109415417A (pt)
AU (1) AU2017291975B2 (pt)
BR (2) BR112019000360A2 (pt)
CA (1) CA3028871A1 (pt)
MX (1) MX2019000075A (pt)
RU (1) RU2760290C1 (pt)
WO (2) WO2018007565A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109803673A (zh) 2016-09-13 2019-05-24 阿勒根公司 非蛋白质梭菌毒素组合物
WO2020013147A1 (ja) 2018-07-10 2020-01-16 日本農薬株式会社 ハロゲン化されていてもよいアルキレンジオキシ基を有するベンゾイミダゾール化合物又はその塩類、及びそれらの化合物を含有する農園芸用殺虫剤並びにその使用方法
CN109468254B (zh) * 2018-11-13 2021-03-26 江南大学 一种提高l-丙氨酸生产效率的方法及其应用
EP3967763A4 (en) * 2019-05-10 2024-01-03 Toray Industries GENETICALLY MODIFIED MICROORGANISM FOR THE PRODUCTION OF 3-HYDROXYHEXANIC ACID, (E)-HEX-2-ENDIONIC ACID AND/OR HEXANEDIONIC ACID AND PRODUCTION PROCESS FOR THESE CHEMICALS
KR102558672B1 (ko) * 2022-05-17 2023-07-25 주식회사 엑티브온 1,3-프로판디올 생산 변이 미생물 및 이를 이용한 1,3-프로판디올의 생산 방법

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4032441B2 (ja) * 1995-08-30 2008-01-16 味の素株式会社 Ｌ−アミノ酸の製造方法
US6087140A (en) 1997-02-19 2000-07-11 Wisconsin Alumni Research Foundation Microbial production of 1,2-propanediol from sugar
JP4110641B2 (ja) 1998-11-17 2008-07-02 味の素株式会社 発酵法によるｌ−メチオニンの製造法
DE10045497A1 (de) 2000-09-13 2002-03-28 Degussa Neue für das ppsA-Gen kodierende Nukleotidsequenzen
US20030219798A1 (en) * 2000-09-29 2003-11-27 Gokarn Ravi R. Isoprenoid production
DE10130192A1 (de) 2000-09-30 2002-04-11 Degussa Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae
PL211169B1 (pl) 2000-09-30 2012-04-30 Degussa Sposób fermentacyjnego wytwarzania L-aminokwasów, drobnoustroje z rodziny Enterobacteriaceae wytwarzające L-aminokwas, plazmid, wyizolowany polinukleotyd, szczepy z rodziny Enterobacteriaceae wytwarzające L-treoninę, szczepy Escherichia coli
CN100554426C (zh) * 2001-08-06 2009-10-28 德古萨股份公司 用遗传修饰的谷氨酸棒杆菌生产l-赖氨酸
CA2500741C (en) 2002-10-04 2017-02-28 Genencor International, Inc. Glucose transport mutants for production of biomaterial
BRPI0314498B1 (pt) 2002-10-04 2019-08-20 E.I. Du Pont De Nemours And Company Escherichia coli transgênica e método para a bioprodução de 1,3-propanodiol
US20060270013A1 (en) 2003-02-18 2006-11-30 Michel Chateau Method for the production of evolved microorganisms which permit the generation or modification of metabolic pathways
FR2864967B1 (fr) * 2004-01-12 2006-05-19 Metabolic Explorer Sa Microorganisme evolue pour la production de 1,2-propanediol
WO2005111202A1 (en) 2004-05-12 2005-11-24 Metabolic Explorer Recombinant enzyme with altered feedback sensitivity
EP2084288A1 (en) 2006-10-31 2009-08-05 Metabolic Explorer Process for the biological production of 1,3-propanediol from glycerol with high yield
WO2008052596A1 (en) 2006-10-31 2008-05-08 Metabolic Explorer Process for the biological production of n-butanol with high yield
CN101573447A (zh) 2006-12-29 2009-11-04 赢创德固赛有限责任公司 具有降低的产物抑制作用的甲硫氨酸合酶
CA2679987A1 (en) * 2007-03-23 2008-10-02 Metabolic Explorer Metabolically engineered microorganism useful for the production of 1,2-propanediol
CA2688450C (en) 2007-03-23 2016-10-25 Metabolic Explorer Microorganisms and methods for production of 1,2-propanediol and acetol
CN101641446A (zh) 2007-03-23 2010-02-03 代谢探索者公司 通过进化和理性设计的组合获得的用于产生1，2-丙二醇的新微生物
ES2534375T3 (es) 2007-04-11 2015-04-22 Cj Cheiljedang Corporation Composiciones y procedimientos de producción de metionina
ES2549003T3 (es) 2008-12-31 2015-10-22 Metabolic Explorer Método para la preparación de dioles
EP2233562A1 (en) 2009-03-24 2010-09-29 Metabolic Explorer Method for producing high amount of glycolic acid by fermentation
EP2248904A1 (en) 2009-05-05 2010-11-10 Metabolic Explorer Continuous culture for 1,3-propanediol production using high glycerine concentration
EP2582828B1 (en) 2010-06-15 2015-07-15 Metabolic Explorer Use of inducible promoters in the production of glycolic acid
TWI500768B (zh) 2010-07-05 2015-09-21 Metabolic Explorer Sa 由蔗糖製備１，３－丙二醇之方法
JP2013537429A (ja) 2010-08-27 2013-10-03 メタボリック エクスプローラー 改変微生物による改良されたグリコール酸発酵生産
AR083468A1 (es) 2010-10-25 2013-02-27 Metabolic Explorer Sa Aumento de la disponibilidad de nadph para la produccion de metionina
AR083799A1 (es) 2010-11-10 2013-03-20 Metabolic Explorer Sa Microorganismos para la produccion de 1,3-propanodiol usando concentracion de glicerina alta
KR101543199B1 (ko) 2010-12-29 2015-08-10 씨제이제일제당 (주) Ｌ-메티오닌 및 관련 산물의 생산방법
EP2479279A1 (de) 2011-01-20 2012-07-25 Evonik Degussa GmbH Verfahren zur fermentativen Herstellung schwefelhaltiger Aminosäuren
EP2532751A1 (en) 2011-06-10 2012-12-12 Metabolic Explorer Use of inducible promoters in the fermentative production of 1,2-propanediol
US9353386B2 (en) 2011-06-15 2016-05-31 B.R.A.I.N. Biotechnology Research And Information Network Ag Means and methods for producing propanediol
FI125136B (en) 2011-10-04 2015-06-15 Teknologian Tutkimuskeskus Vtt Oy Eukaryotic cells and a method for preparing glycolic acid
EP2700715B1 (de) 2012-08-20 2018-07-25 Evonik Degussa GmbH Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae
FI20135333L (fi) 2013-04-05 2014-10-06 Teknologian Tutkimuskeskus Vtt Oy Hapon / happojen ja alkoholin tuotto sokereista käyttämällä hiivaa
US9363091B2 (en) * 2013-12-23 2016-06-07 Louroe Electronics Power over Ethernet devices, systems and methods
WO2015173247A1 (en) 2014-05-12 2015-11-19 Metabolic Explorer New microorganism and method for the production of 1.2-propanediol based on nadph dependent acetol reductase and improved nadph supply
US10294482B2 (en) * 2014-05-22 2019-05-21 Yeda Research And Development Co. Ltd. Recombinant microorganisms capable of carbon fixation
RU2723714C2 (ru) 2014-09-01 2020-06-17 Эвоник Оперейшнс Гмбх Способ и микроорганизм для ферментативного продуцирования метионина с улучшенным выходом метионина
WO2016050959A2 (en) 2014-10-03 2016-04-07 Metabolic Explorer Mutant glutamate dehydrogenase for the conversion of homoserine into 4-hydroxy-2-ketobutyrate

Also Published As

Publication number Publication date
RU2760290C1 (ru) 2021-11-23
US20190276859A1 (en) 2019-09-12
WO2018007565A1 (en) 2018-01-11
CN109415418A (zh) 2019-03-01
EP3481851B1 (en) 2021-11-24
US20190276794A1 (en) 2019-09-12
US10961499B2 (en) 2021-03-30
JP7321089B2 (ja) 2023-08-04
EP3481851A1 (en) 2019-05-15
BR112019000132A2 (pt) 2019-04-16
KR20190025969A (ko) 2019-03-12
AU2017291975B2 (en) 2021-06-03
EP3481850A1 (en) 2019-05-15
CA3028871A1 (en) 2018-01-11
MX2019000075A (es) 2019-05-02
AU2017291975A1 (en) 2019-01-24
CN109415417A (zh) 2019-03-01
WO2018007560A1 (en) 2018-01-11
JP2019520081A (ja) 2019-07-18
KR20190026851A (ko) 2019-03-13
KR102430878B1 (ko) 2022-08-09
CN109415418B (zh) 2024-02-09

Similar Documents

Publication Publication Date Title
BR112019000360A2 (pt) método e microrganismo geneticamente modificado para a produção de metionina ou sua forma análoga de hidróxi
BR112015010134A2 (pt) Processo para consumo de acetato durante a fermentação etanólica de matérias-primas celulósicas
BR112018009393A8 (pt) produção microbiana de nicotinamida ribosídeo
BR112018008864A8 (pt) meios e métodos de fermentação para a produção de polissacarídeos em uma cultura de células bacterianas
BR112013018385A2 (pt) microorganismo com produtividade de l-aminoácidos aumentada e processo de produção de l-aminoácidos usando o mesmo
BR112012003883A8 (pt) Microorganismos recombinantes, processo de conversão de biomassa lignocelulósica em 1,2-propanodiol ou isopropanol, via metabólica engenheirada, agrupamento genético, e método de identificação de diol desidratase independente da vitamina b12 que converte propanodiol em propanal
BR112017021255A2 (pt) microrganismo modificado para a produção otimizada de 2,4-di-hidroxibutirato
BR112016002067A2 (pt) Variantes de enzimas
BR112016027290A2 (pt) métodos para a produção de ramnolipídeos".
BR112013016810A2 (pt) métodos para produção de l-metionina e produtos relacionados
BR112016020517A2 (pt) método de produção de lipídeo através da utilização de ss-cetoacil-acp sintase
BR112014014151A2 (pt) células fúngicas e processos de fermentação
BR112015005416A2 (pt) produção de ácidos orgânicos por meio de fermentação em baixo ph
BR112016007182A2 (pt) método para produzir um l-aminoácido
BR112019009839A2 (pt) método para a produção enzimática de um anticorpo e anticorpo
BR102014009838B8 (pt) Método para produzir um l-aminoácido
BR112016025791A2 (pt) microrganismo modificado, método para produzir um composto orgânico e uso de um microrganismo modificado
BR112016023823A2 (pt) método para produção de um produto de fermentação
BR112018006390A2 (pt) método para fermentar um micro-organismo que produz um produto de proteína
BR112015023475A2 (pt) método para recuperar uma composição enriquecida em ácido 3-hidroxipropiônico
BR112016002105A2 (pt) Microrganismo modificado, método para produzir alanina e uso de um microrganismo modificado
ZA202205485B (en) L-methionine producing microorganism to which protein encoded by foreign metz gene is introduced and method for producing l-methionine using same
BR112013020216A2 (pt) Processo para produzir substância-alvo através do processo de fermentação
BR112016018195A2 (pt) micro-organismo modificado, método de produção de um composto orgânico e uso de um micro-organismo modificado
BR112016018193A2 (pt) micro-organismo modificado, método de produção de composto orgânico e uso de micro-organismo modificado

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]