BR112018013873A2 - método para a produção fermentativa de l-metionina e/ou seus derivados - Google Patents
método para a produção fermentativa de l-metionina e/ou seus derivadosInfo
- Publication number
- BR112018013873A2 BR112018013873A2 BR112018013873A BR112018013873A BR112018013873A2 BR 112018013873 A2 BR112018013873 A2 BR 112018013873A2 BR 112018013873 A BR112018013873 A BR 112018013873A BR 112018013873 A BR112018013873 A BR 112018013873A BR 112018013873 A2 BR112018013873 A2 BR 112018013873A2
- Authority
- BR
- Brazil
- Prior art keywords
- methionine
- fermentative production
- derivatives
- recovering
- source
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/12—Methionine; Cysteine; Cystine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/26—Separation; Purification; Stabilisation; Use of additives
- C07C319/28—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
a presente invenção refere-se a um método para a produção fermentativa de l-metionina e/ou seus derivados que compreende a etapa de i) cultivar um micro-organismo otimizado para a produção fermentativa de metionina em um meio de cultura apropriado que compreende uma fonte de carbono, uma fonte de enxofre e fonte de nitrogênio para produzir l-metionina; ii) recuperar a l-metionina obtida na etapa i); iii) adicionar um solvente alcoólico ou acetonitrila à fração que contém metionina obtida na etapa ii) para precipitar a l-metionina; e iv) recuperar l-metionina.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2016/000122 WO2017118871A1 (en) | 2016-01-08 | 2016-01-08 | Method to produce l-methionine by a fermentative production |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018013873A2 true BR112018013873A2 (pt) | 2018-12-18 |
Family
ID=55486985
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018013873A BR112018013873A2 (pt) | 2016-01-08 | 2016-01-08 | método para a produção fermentativa de l-metionina e/ou seus derivados |
Country Status (8)
Country | Link |
---|---|
US (1) | US20180355390A1 (pt) |
EP (1) | EP3400305A1 (pt) |
KR (1) | KR20180093981A (pt) |
CN (1) | CN108603207A (pt) |
BR (1) | BR112018013873A2 (pt) |
MX (1) | MX2018008129A (pt) |
RU (1) | RU2018128142A (pt) |
WO (1) | WO2017118871A1 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11882852B2 (en) | 2018-02-09 | 2024-01-30 | Haldor Topsøe A/S | Process of producing alpha-hydroxy compounds and uses thereof |
KR102489243B1 (ko) * | 2020-09-11 | 2023-01-16 | 고려대학교 산학협력단 | S-메틸메티오닌 생산용 재조합 미생물 및 이를 이용한 s-메틸메티오닌의 제조방법 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6881837B2 (en) * | 2001-06-07 | 2005-04-19 | Orchid Chemicals & Pharmaceuticals Ltd. | Chemical synthesis of S-adenosyl-L-methionine with enrichment of (S,S)-isomer |
DE10249642A1 (de) | 2002-10-24 | 2004-05-13 | Consortium für elektrochemische Industrie GmbH | Feedback-resistente Homoserin-Transsuccinylasen mit modifiziertem C-Terminus |
US7252756B2 (en) * | 2002-12-18 | 2007-08-07 | Bp Corporation North America Inc. | Preparation of components for refinery blending of transportation fuels |
EP1656454A4 (en) | 2003-07-08 | 2011-06-22 | Novus Int Inc | PROCESS FOR METHIONINAL RECOVERY |
DE10359668A1 (de) * | 2003-12-18 | 2005-07-14 | Basf Ag | Verfahren zur Herstellung von Methionin |
WO2005111202A1 (en) | 2004-05-12 | 2005-11-24 | Metabolic Explorer | Recombinant enzyme with altered feedback sensitivity |
KR100651220B1 (ko) | 2004-06-29 | 2006-11-29 | 씨제이 주식회사 | L-메씨오닌 생산 균주 및 상기 균주를 이용한l-메씨오닌의 생산방법 |
WO2006138689A2 (en) | 2005-06-17 | 2006-12-28 | Microbia, Inc. | Improved amino acid and metabolite biosynthesis |
KR20080036608A (ko) | 2005-07-18 | 2008-04-28 | 바스프 에스이 | 메티오닌 생산 재조합 미생물 |
WO2007017710A1 (en) | 2005-08-11 | 2007-02-15 | Metabolic Explorer | Process for the preparation of aspartate and derived amino acids like lysine, threonine, isoleucine, methionine, homoserine, or valine employing a microorganism with enhanced isocitrate lyase and/or malate synthase expression |
BRPI0620880B1 (pt) | 2006-01-04 | 2018-10-09 | Evonik Degussa Gmbh | método para a produção de metionina, pelo cultivo de um microorganismo, e, microorganismo |
WO2009043372A1 (en) | 2007-10-02 | 2009-04-09 | Metabolic Explorer | Increasing methionine yield |
KR101164711B1 (ko) * | 2009-02-27 | 2012-07-11 | 씨제이제일제당 (주) | 미네랄 첨가와 산처리를 이용하여 메치오닌의 용해도를 증가시키는 방법 |
FR2951195B1 (fr) | 2009-10-14 | 2014-01-31 | Roquette Freres | Composition riche en methionine destinee a l'alimentation animale |
JP6368488B2 (ja) * | 2010-12-29 | 2018-08-01 | シージェイ チェイルジェダン コーポレーション | L−メチオニン及び関連産物の生産方法 |
EP2479279A1 (de) | 2011-01-20 | 2012-07-25 | Evonik Degussa GmbH | Verfahren zur fermentativen Herstellung schwefelhaltiger Aminosäuren |
AR086790A1 (es) | 2011-06-29 | 2014-01-22 | Metabolic Explorer Sa | Un microorganismo para la produccion de metionina con importacion de glucosa mejorada |
FR2983870B1 (fr) | 2011-12-08 | 2015-07-17 | Roquette Freres | Composition en methionine destinee a l'alimentation animale |
US9506093B2 (en) * | 2012-06-18 | 2016-11-29 | Metabolic Explorer | Recombinant microorganism for the fermentative production of methionine |
CN105658785B (zh) | 2013-08-30 | 2019-12-06 | 赢创德固赛有限公司 | 具有增强的甲硫氨酸流出的用于甲硫氨酸生产的微生物 |
EP3039153B1 (en) | 2013-08-30 | 2018-08-22 | Evonik Degussa GmbH | Microorganism for methionine production with improved methionine synthase activity and methionine efflux |
-
2016
- 2016-01-08 WO PCT/IB2016/000122 patent/WO2017118871A1/en active Application Filing
- 2016-01-08 RU RU2018128142A patent/RU2018128142A/ru unknown
- 2016-01-08 BR BR112018013873A patent/BR112018013873A2/pt not_active Application Discontinuation
- 2016-01-08 CN CN201680077838.8A patent/CN108603207A/zh active Pending
- 2016-01-08 US US15/774,267 patent/US20180355390A1/en not_active Abandoned
- 2016-01-08 EP EP16708717.0A patent/EP3400305A1/en not_active Withdrawn
- 2016-01-08 MX MX2018008129A patent/MX2018008129A/es unknown
- 2016-01-08 KR KR1020187019091A patent/KR20180093981A/ko unknown
Also Published As
Publication number | Publication date |
---|---|
KR20180093981A (ko) | 2018-08-22 |
RU2018128142A (ru) | 2020-02-10 |
US20180355390A1 (en) | 2018-12-13 |
EP3400305A1 (en) | 2018-11-14 |
MX2018008129A (es) | 2018-12-06 |
CN108603207A (zh) | 2018-09-28 |
WO2017118871A1 (en) | 2017-07-13 |
RU2018128142A3 (pt) | 2020-02-10 |
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Legal Events
Date | Code | Title | Description |
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B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] |