BR112018013873A2 - método para a produção fermentativa de l-metionina e/ou seus derivados - Google Patents

método para a produção fermentativa de l-metionina e/ou seus derivados

Info

Publication number
BR112018013873A2
BR112018013873A2 BR112018013873A BR112018013873A BR112018013873A2 BR 112018013873 A2 BR112018013873 A2 BR 112018013873A2 BR 112018013873 A BR112018013873 A BR 112018013873A BR 112018013873 A BR112018013873 A BR 112018013873A BR 112018013873 A2 BR112018013873 A2 BR 112018013873A2
Authority
BR
Brazil
Prior art keywords
methionine
fermentative production
derivatives
recovering
source
Prior art date
Application number
BR112018013873A
Other languages
English (en)
Inventor
Sevenier Antoine
Colomb Cédric
Faure Laetitia
Chateau Michel
Original Assignee
Evonik Degussa Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Degussa Gmbh filed Critical Evonik Degussa Gmbh
Publication of BR112018013873A2 publication Critical patent/BR112018013873A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

a presente invenção refere-se a um método para a produção fermentativa de l-metionina e/ou seus derivados que compreende a etapa de i) cultivar um micro-organismo otimizado para a produção fermentativa de metionina em um meio de cultura apropriado que compreende uma fonte de carbono, uma fonte de enxofre e fonte de nitrogênio para produzir l-metionina; ii) recuperar a l-metionina obtida na etapa i); iii) adicionar um solvente alcoólico ou acetonitrila à fração que contém metionina obtida na etapa ii) para precipitar a l-metionina; e iv) recuperar l-metionina.
BR112018013873A 2016-01-08 2016-01-08 método para a produção fermentativa de l-metionina e/ou seus derivados BR112018013873A2 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2016/000122 WO2017118871A1 (en) 2016-01-08 2016-01-08 Method to produce l-methionine by a fermentative production

Publications (1)

Publication Number Publication Date
BR112018013873A2 true BR112018013873A2 (pt) 2018-12-18

Family

ID=55486985

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018013873A BR112018013873A2 (pt) 2016-01-08 2016-01-08 método para a produção fermentativa de l-metionina e/ou seus derivados

Country Status (8)

Country Link
US (1) US20180355390A1 (pt)
EP (1) EP3400305A1 (pt)
KR (1) KR20180093981A (pt)
CN (1) CN108603207A (pt)
BR (1) BR112018013873A2 (pt)
MX (1) MX2018008129A (pt)
RU (1) RU2018128142A (pt)
WO (1) WO2017118871A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019154624A1 (en) 2018-02-09 2019-08-15 Haldor Topsøe A/S Process of producing alpha-hydroxy compounds and uses thereof
KR102489243B1 (ko) * 2020-09-11 2023-01-16 고려대학교 산학협력단 S-메틸메티오닌 생산용 재조합 미생물 및 이를 이용한 s-메틸메티오닌의 제조방법
WO2024175452A1 (en) * 2023-02-22 2024-08-29 Evonik Operations Gmbh Apparatus and process for recovery of a valuable material

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6881837B2 (en) * 2001-06-07 2005-04-19 Orchid Chemicals & Pharmaceuticals Ltd. Chemical synthesis of S-adenosyl-L-methionine with enrichment of (S,S)-isomer
DE10249642A1 (de) 2002-10-24 2004-05-13 Consortium für elektrochemische Industrie GmbH Feedback-resistente Homoserin-Transsuccinylasen mit modifiziertem C-Terminus
US7252756B2 (en) * 2002-12-18 2007-08-07 Bp Corporation North America Inc. Preparation of components for refinery blending of transportation fuels
US8338141B2 (en) * 2003-07-08 2012-12-25 Novus International, Inc. Methionine recovery processes
DE10359668A1 (de) 2003-12-18 2005-07-14 Basf Ag Verfahren zur Herstellung von Methionin
WO2005111202A1 (en) 2004-05-12 2005-11-24 Metabolic Explorer Recombinant enzyme with altered feedback sensitivity
KR100651220B1 (ko) 2004-06-29 2006-11-29 씨제이 주식회사 Ｌ-메씨오닌 생산 균주 및 상기 균주를 이용한ｌ-메씨오닌의 생산방법
AU2006261356A1 (en) 2005-06-17 2006-12-28 Microbia, Inc. Improved amino acid and metabolite biosynthesis
JP2009501550A (ja) 2005-07-18 2009-01-22 ビーエーエスエフ ソシエタス・ヨーロピア メチオニン生産組換え微生物
WO2007017710A1 (en) 2005-08-11 2007-02-15 Metabolic Explorer Process for the preparation of aspartate and derived amino acids like lysine, threonine, isoleucine, methionine, homoserine, or valine employing a microorganism with enhanced isocitrate lyase and/or malate synthase expression
WO2007077041A1 (en) 2006-01-04 2007-07-12 Metabolic Explorer Process for the preparation of methionine and its precursors homoserine or succinylhomoserine employing a microorganism with enhanced sulfate permease expression
WO2009043372A1 (en) 2007-10-02 2009-04-09 Metabolic Explorer Increasing methionine yield
KR101164711B1 (ko) * 2009-02-27 2012-07-11 씨제이제일제당 (주) 미네랄 첨가와 산처리를 이용하여 메치오닌의 용해도를 증가시키는 방법
FR2951195B1 (fr) 2009-10-14 2014-01-31 Roquette Freres Composition riche en methionine destinee a l'alimentation animale
CN103476938B (zh) * 2010-12-29 2016-10-12 Cj第一制糖株式会社 L-甲硫氨酸和相关产物的生产方法
EP2479279A1 (de) 2011-01-20 2012-07-25 Evonik Degussa GmbH Verfahren zur fermentativen Herstellung schwefelhaltiger Aminosäuren
AR086790A1 (es) 2011-06-29 2014-01-22 Metabolic Explorer Sa Un microorganismo para la produccion de metionina con importacion de glucosa mejorada
FR2983870B1 (fr) 2011-12-08 2015-07-17 Roquette Freres Composition en methionine destinee a l'alimentation animale
CN104411821B (zh) * 2012-06-18 2017-08-08 代谢探索者公司 用于发酵生产甲硫氨酸的重组微生物
PL3039153T3 (pl) 2013-08-30 2019-02-28 Evonik Degussa Gmbh Mikroorganizm do wytwarzania metioniny o ulepszonej aktywności syntazy metioniny i wypływie metioniny
KR20160044038A (ko) 2013-08-30 2016-04-22 메타볼릭 익스플로러 메티오닌 유출이 증진된 메티오닌 생산용 미생물

Also Published As

Publication number Publication date
RU2018128142A3 (pt) 2020-02-10
US20180355390A1 (en) 2018-12-13
MX2018008129A (es) 2018-12-06
RU2018128142A (ru) 2020-02-10
KR20180093981A (ko) 2018-08-22
EP3400305A1 (en) 2018-11-14
WO2017118871A1 (en) 2017-07-13
CN108603207A (zh) 2018-09-28

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Legal Events

Date Code Title Description
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements
B350 Update of information on the portal [chapter 15.35 patent gazette]